STEPdb: Sub-cellular Topologies of E.coli Polypeptides.

Table: Type three secretion effectors in EPEC (O127:H6)  Export to Excel  Export to HTML  Export to XML  Export to CSV  

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Type three secretion effectors in EPEC (O127:H6)


EPEC effectors encoded on the LEE locus

Effector
Protein ID
(Uniprot)
Chaperone
Homologues
Tir
B7UM99
CesT1
None known
Map
B7UMA0
CesT1
IpgB2
EspF
B7UM88
CesF3
TccP/EspFU
EspG
B7UMC8
None known
VirA4
EspH
B7UMA2
None known
None known
EspZ
B7UMA9
None known
None known
EspB
Q05129
CesAB5 CesD6
YopD
Records 1 to 7 of 7     
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* EspB does not belong to the class of effectors, but has been reported to play roles in pathogenesis.



References:
1 (Creasey et al., 2003a)
Creasey, E.A., Delahay, R.M., Bishop, A.A., Shaw, R.K., Kenny, B., Knutton, S., and Frankel, G. (2003a).CesT is a bivalent enteropathogenic Escherichia coli chaperone required for translocation of both Tir and Map. MolMicrobiol 47, 209-221. PMID: 12492865
2 (Tobe et al., 2006)
Tobe, T., Beatson, S.A., Taniguchi, H., Abe, H., Bailey, C.M., Fivian, A., Younis, R., Matthews, S., Marches, O., Frankel, G., et al. (2006).An extensive repertoire of type III secretion effectors in Escherichia coli O157 and the role of lambdoid phages in their dissemination. Proc Natl AcadSci U S A 103, 14941-14946. PMID: 16990433
3 (Elliott et al., 2002)
Elliott, S.J., O'Connell, C.B., Koutsouris, A., Brinkley, C., Donnenberg, M.S., Hecht, G., and Kaper, J.B. (2002). A gene from the locus of enterocyte effacement that is required for enteropathogenic Escherichia coli to increase tight-junction permeability encodes a chaperone for EspF. Infect Immun 70, 2271-2277. PMID: 11953359
4 (Elliott et al., 2001)
Elliott, S.J., Krejany, E.O., Mellies, J.L., Robins-Browne, R.M., Sasakawa, C., and Kaper, J.B. (2001). EspG, a novel type III system-secreted protein from enteropathogenic Escherichia coli with similarities to VirA of Shigella flexneri. Infect Immun 69, 4027-4033. PMID: 11349072
5 (Creasey et al., 2003b)
Creasey, E.A., Friedberg, D., Shaw, R.K., Umanski, T., Knutton, S., Rosenshine, I., and Frankel, G. (2003).CesAB is an enteropathogenic Escherichia coli chaperone for the type-III translocator proteins EspA and EspB. Microbiology 149, 3639-3647. PMID: 14663095
6 (Wainwright and Kaper, 1998)
Wainwright, L.A., and Kaper, J.B. (1998). EspB and EspD require a specific chaperone for proper secretion from enteropathogenic Escherichia coli. MolMicrobiol 27, 1247-1260. PMID: 9570409
7 (Pearson et al., 2016)
Pearson, J.S., Giogha, C., Wong Fok Lung, T., and Hartland, E.L. (2016). The Genetics of Enteropathogenic Escherichia coli Virulence. Annual review of genetics 50, 493-513. PMID: 27893961
7 (Wong et al., 2011)
Wong, A.R., Pearson, J.S., Bright, M.D., Munera, D., Robinson, K.S., Lee, S.F., Frankel, G., and Hartland, E.L. (2011). Enteropathogenic and enterohaemorrhagic Escherichia coli: even more subversive elements. Mol Microbiol 80, 1420-1438. PMID: 21488979
7 (Dean and Kenny, 2009)
Dean, P., and Kenny, B. (2009). The effector repertoire of enteropathogenic E. coli: ganging up on the host cell. Curr Opin Microbiol 12, 101-109. PMID: 19144561

 

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