STEPdb: Sub-cellular Topologies of E.coli Polypeptides.

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E.coli K-12 (MG1655) Exportome

(mouse over and click on the one letter topology symbols to see which proteins of this specific subproteome are localized in each location)

Bacterial cell cartoon of sub-cellular locations


Protein ID
(Uniprot)
Accession
(Uniprot)
Gene Name
(Uniprot)
Order
Locus Name
Protein Name
(Uniprot)
Full Name
Symbol
Uniprot
EchoLOCATION
Extracellular Appendage
First Level
Targeting
Chaperoning
First Level
Secretion
System
Second Level
Targeting
Chaperoning
Second Level
Secretion
System
K-12 Core
Proteome
(yes/no)
K-12 Basic
Proteome
(yes/no)
IBSD_ECOLI
C1P616
ibsD
b4664 JW3023.1
Autoinducer 2 import system permease protein lsrD (AI-2 import system permease protein lsrD)
Integral Inner Membrane
B
N/A
Membrane | Single-pass membrane protein
-
 
 
SEC
 
 
no
yes
PMRR_ECOLI
G3MTW7
pmrR
b4703 JW4072.1
Putative membrane protein PmrR
Integral Inner Membrane
B
N/A
 
 
 
 
SEC
 
 
no
 
YPDI_ECOLI
O32528
ypdI
b2376 JW2373
Uncharacterized lipoprotein ypdI
Outer Membrane Lipoprotein
I
N/A
Cell membrane | Lipid-anchor
Outer membrane Lipoprotein
 
 
SEC
 
LOL
no
yes
YFJS_ECOLI
O52982
yfjS
b2636 JW5921
Uncharacterized lipoprotein yfjS
Inner Membrane Lipoprotein
E
N/A
Cell membrane | Lipid-anchor
Inner membrane lipoprotein
 
 
SEC
 
LOL
no
no
GSPB_ECOLI
P03825
gspB

pinO pioO pno

b3322 JW3284
Putative general secretion pathway protein B
Integral Inner Membrane
B
IM (predicted)
 
Membrane anchored
 
SRP
SEC
 
 
no
yes
BTUE_ECOLI
P06610
btuE
b1710 JW1700
Vitamin B12 transport periplasmic protein BtuE (EC 1.-.-.-)
Periplasmic
G
N/A
Periplasm
Cytoplasmic
 
 
SEC, non classical
 
 
yes
yes
SODM_ECOLI
P00448
sodA
b3908 JW3879
Superoxide dismutase [Mn] (EC 1.15.1.1) (MnSOD)
Periplasmic
G
N/A
 
Cytoplasmic
 
 
SEC, non classical
 
 
yes
yes
PHSM_ECOLI
P00490
malP
b3417 JW5689
Maltodextrin phosphorylase (EC 2.4.1.1)
Integral Inner Membrane
B
Soluble IM Fraction
 
Cytoplasmic
 
 
SEC
 
 
yes
yes
PTM3C_ECOLI
P00550
mtlA
b3599 JW3573
PTS system mannitol-specific EIICBA component (EIICBA-Mtl) (EII-Mtl) [Includes: Mannitol permease IIC component (PTS system mannitol-specific EIIC component); Mannitol-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system mannitol-spe
Integral Inner Membrane
B
IM (predicted), Detected in IM Fraction
Cell inner membrane | Multi-pass membrane protein
Integral Membrane Protein
 
SRP (exp)
SEC
 
 
yes
yes
YGDB_ECOLI
P08370
ygdB
b2824 JW5450
Uncharacterized protein ygdB
Periplasmic
G
N/A
 
Periplasmic
 
 
SEC
 
 
yes
yes
PPDB_ECOLI
P08371
ppdB

ygdC

b2825 JW5451
Prepilin peptidase-dependent protein B
Integral Inner Membrane
B
IM (predicted)
 
Membrane anchored
 
SRP
SEC
 
 
yes
yes
PPDC_ECOLI
P08372
ppdC

ygdA

b2823 JW2791
Prepilin peptidase-dependent protein C
Integral Inner Membrane
B
IM (predicted)
 
Membrane anchored
 
SRP
SEC
 
 
yes
yes
PPB_ECOLI
P00634
phoA
b0383 JW0374
Alkaline phosphatase (APase) (EC 3.1.3.1)
Periplasmic
G
N/A
Periplasm
Periplasmic (Experimental)
 
 
SEC
DSBA
 
no
yes
LEP_ECOLI
P00803
lepB
b2568 JW2552
Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I)
Integral Inner Membrane
B
IM (predicted)
Cell inner membrane | Multi-pass membrane protein
Integral Membrane Protein
 
 
YidC
 
 
yes
yes
LSPA_ECOLI
P00804
lspA
b0027 JW0025
Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II)
Integral Inner Membrane
B
IM (predicted)
Cell inner membrane | Multi-pass membrane protein
Integral Membrane Protein
 
SRP
SEC
 
 
yes
yes
ASPG2_ECOLI
P00805
ansB
b2957 JW2924
L-asparaginase 2 (EC 3.5.1.1) (L-asparaginase II) (L-ASNase II) (L-asparagine amidohydrolase II) (Colaspase)
Periplasmic
G
N/A
Periplasm
Periplasmic (Experimental)
 
 
SEC
 
 
yes
yes
CVPA_ECOLI
P08550
cvpA

dedE

b2313 JW2310
Colicin V production protein (Protein dedE) (Pur regulon 18 kDa protein)
Integral Inner Membrane
B
IM (predicted)
Cell inner membrane | Multi-pass membrane protein
Integral Membrane Protein (Experimental)
 
SRP
SEC
 
 
yes
yes
FTSB_ECOLI
P0A6S5
ftsB

ygbQ

b2748 JW2718
Cell division protein ftsB
Integral Inner Membrane
B
IM (predicted)
Cell inner membrane | Single-pass type II membrane protein
Membrane anchored
 
SRP
SEC
 
 
yes
yes
ISPZ_ECOLI
P0A710
yciB

ispZ

b1254 JW1246
Probable intracellular septation protein
Integral Inner Membrane
B
IM (predicted)
Cell inner membrane | Multi-pass membrane protein
Integral Membrane Protein
 
SRP
SEC
 
 
yes
yes
AMPC_ECOLI
P00811
ampC

ampA

b4150 JW4111
Beta-lactamase (EC 3.5.2.6) (Cephalosporinase)
Periplasmic
G
N/A
Periplasm
Periplasmic (Experimental)
 
 
SEC
 
 
yes
yes
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