STEPdb: Sub-cellular Topologies of E.coli Polypeptides.

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Disulfideome of E.coli K-12 (MG1655) proteome

Bacterial cell cartoon of sub-cellular locations


Protein ID
(Uniprot)
Accession
(Uniprot)
Gene Name
(Uniprot)
Order
Locus Name
Protein Name
(Uniprot)
Full Name
Symbol
Uniprot
EchoLOCATION
Extracellular Appendage
First Level
Targeting
Chaperoning
First Level
Secretion
System
Second Level
Targeting
Chaperoning
Second Level
Secretion
System
K-12 Core
Proteome
(yes/no)
K-12 Basic
Proteome
(yes/no)
RIR1_ECOLI
P00452
nrdA

dnaF

b2234 JW2228
Ribonucleoside-diphosphate reductase 1 subunit alpha (EC 1.17.4.1) (Protein B1) (Ribonucleoside-diphosphate reductase 1 R1 subunit) (Ribonucleotide reductase 1)
Peripheral inner membrane protein facing the cytoplasm
F1
N/A
 
Cytoplasmic
 
TF
 
 
 
yes
yes
AK2H_ECOLI
P00562
metL

metM

b3940 JW3911
Bifunctional aspartokinase/homoserine dehydrogenase 2 (Aspartokinase II/homoserine dehydrogenase II) (AKII-HDII) [Includes: Aspartokinase (EC 2.7.2.4); Homoserine dehydrogenase (EC 1.1.1.3)]
Peripheral inner membrane protein facing the cytoplasm
F1
N/A
 
Cytoplasmic
 
 
 
 
 
yes
yes
PPB_ECOLI
P00634
phoA
b0383 JW0374
Alkaline phosphatase (APase) (EC 3.1.3.1)
Periplasmic
G
N/A
Periplasm
Periplasmic (Experimental)
 
 
SEC
DSBA
 
no
yes
BTUE_ECOLI
P06610
btuE
b1710 JW1700
Vitamin B12 transport periplasmic protein BtuE (EC 1.-.-.-)
Periplasmic
G
N/A
Periplasm
Cytoplasmic
 
 
SEC, non classical
 
 
yes
yes
RL31_ECOLI
P0A7M9
rpmE
b3936 JW3907
50S ribosomal protein L31
Ribosomal
r
N/A
 
Cytoplasmic
 
 
 
 
 
yes
yes
FLHD_ECOLI
P0A8S9
flhD

flbB

b1892 JW1881
Transcriptional activator FlhD
Nucleoid
N
N/A
Cytoplasm
Cytoplasmic
 
 
 
 
 
no
yes
LEP_ECOLI
P00803
lepB
b2568 JW2552
Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I)
Integral Inner Membrane
B
IM (predicted)
Cell inner membrane | Multi-pass membrane protein
Integral Membrane Protein
 
 
YidC
 
 
yes
yes
ASPG2_ECOLI
P00805
ansB
b2957 JW2924
L-asparaginase 2 (EC 3.5.1.1) (L-asparaginase II) (L-ASNase II) (L-asparagine amidohydrolase II) (Colaspase)
Periplasmic
G
N/A
Periplasm
Periplasmic (Experimental)
 
 
SEC
 
 
yes
yes
SYI_ECOLI
P00956
ileS

ilvS

b0026 JW0024
Isoleucyl-tRNA synthetase (EC 6.1.1.5) (Isoleucine--tRNA ligase) (IleRS)
Cytoplasmic
A
N/A
Cytoplasm
Cytoplasmic
 
 
 
 
 
yes
yes
SYGA_ECOLI
P00960
glyQ

glyS(A)

b3560 JW3531
Glycyl-tRNA synthetase alpha subunit (EC 6.1.1.14) (Glycine--tRNA ligase alpha subunit) (GlyRS)
Peripheral inner membrane protein facing the cytoplasm
F1
N/A
Cytoplasm
Cytoplasmic
 
TF
 
 
 
no
yes
YEDF_ECOLI
P0AA31
yedF
b1930 JW1915
UPF0033 protein yedF
Cytoplasmic
A
N/A
 
Cytoplasmic
 
 
 
 
 
no
yes
YAJD_ECOLI
P0AAQ2
yajD
b0410 JW0400
Uncharacterized protein yajD
Cytoplasmic
A
N/A
 
Cytoplasmic
 
 
 
 
 
yes
yes
YBEL_ECOLI
P0AAT9
ybeL
b0643 JW0638
Uncharacterized protein ybeL
Cytoplasmic
A
N/A
 
Cytoplasmic
 
 
 
 
 
yes
yes
LAMB_ECOLI
P02943
lamB

malB

b4036 JW3996
Maltoporin (Lambda receptor protein) (Maltose-inducible porin)
Outer Membrane b-barrel protein
H
Soluble IM Fraction
Cell outer membrane | Multi-pass membrane protein
Outer Membrane β-barrel protein (Experimental)
 
 
SEC
SKP,SURA,DEGP
BAM
yes
yes
FIMA1_ECOLI
P04128
fimA

pilA

b4314 JW4277
Type-1 fimbrial protein, A chain (Type-1A pilin)
Peripheral outer membrane protein facing the extra-cellular space
F4
N/A
Fimbrium
Cell surface appendage (Experimental)
fimbriae
 
SEC
 
CU
yes
yes
TYRB_ECOLI
P04693
tyrB
b4054 JW4014
Aromatic-amino-acid aminotransferase (ARAT) (AROAT) (EC 2.6.1.57)
Cytoplasmic
A
N/A
Cytoplasm
Cytoplasmic
 
 
 
 
 
yes
yes
LIVK_ECOLI
P04816
livK
b3458 JW3423
Leucine-specific-binding protein (L-BP) (LS-BP)
Periplasmic
G
N/A
Periplasm
Periplasmic (Experimental)
 
 
SEC
DSBA
 
yes
yes
YBGS_ECOLI
P0AAV6
ybgS
b0753 JW0736
Uncharacterized protein ybgS
Periplasmic
G
N/A
 
Periplasmic
 
 
SEC
 
 
yes
yes
YCAR_ECOLI
P0AAZ7
ycaR
b0917 JW0900
UPF0434 protein ycaR
Cytoplasmic
A
N/A
 
Cytoplasmic
 
 
 
 
 
no
yes
YMGD_ECOLI
P0AB46
ymgD
b1171 JW5177
Uncharacterized protein ymgD
Periplasmic
G
N/A
 
Periplasmic
 
 
SEC
 
 
no
yes
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