entryaccgenealt_geneolnprotein_namecm_locacm_notescm_refssuboci_fullsublocisubloci_iimnterm_ctermbernselsubloci_uniprotsubloci_echoLorganelletarget_chaperoning11st_sstarget_chaperoning22nd_sspseudocommon_corebasic_proteomesignalp_sp_existsignalp_possignalp_cmaxlipop_predlipop_cleavagelipop_scorelipop_ruletmhmmphobius_tmsphobius_sp_existphobius_predictionpsortb_locapsortb_scoresolubility
YKFM_ECOLIA5A605
ykfM
b4586 L-fucose-proton symporter (6-deoxy-L-galactose permease) (L-fucose permease)Integral Inner Membrane BBpolyin/outIM (predicted)Membrane | Multi-pass membrane protein-SRPSECnoyesN270.205TMH013.6098-330i12-32o52-75i96-119oCytoplasmicMembrane10
YNCL_ECOLIA5A615
yncL
b4598 JW1439.1 Putative O-antigen transporterInner membrane.Small membrane protein detected experimentally. Found to co-fractionate with the inner membrane.PMID: 19121005 PMID: 21778229Integral Inner Membrane BBinoutin/outIM (predicted)Membrane | Single-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN270.099CYT0-0.200913-110i7-29oCytoplasmicMembrane9.82
YNEM_ECOLIA5A616
yneM
b4599 JW1527.1 Uncharacterized protein yneMInner membrane (experimental). Inner membrane (experimental).Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(out)-C(in).PMID: 19121005 PMID: 21778229Integral Inner Membrane BBinoutin/outN/AMembrane | Single-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN240.123CYT0-0.200913-110i7-25oCytoplasmicMembrane9.82
YDGU_ECOLIA5A617
ydgU
b4601 JW1589 Uncharacterized protein yfbLSmall membrane protein detected experimentally.PMID: 19121005Integral Inner Membrane BBinoutin/outIM (predicted)-SRPSECnoyesN270.097CYT0-0.200913-110i7-26oUnknown2
YNHF_ECOLIA5A618
ynhF
b4602 JW1649.1 O-antigen polymeraseInner membrane (experimental). Inner membrane (experimental).Found to co-fractionate with the inner membrane. Can be inserted in both orientations (Cout-Nin and Cin-Nout).PMID: 19121005 PMID: 21778229 PMID: 21778229 PMID: 21778229Integral Inner Membrane BBinout, Bmultiin/out, out/inIM (predicted)Membrane | Single-pass membrane protein-SRPSECnoyesN270.105CYT0-0.200913-110i7-28oCytoplasmicMembrane9.82
DINQ_ECOLIA5A624
dinQ
b4613 Uncharacterized protein DinQIntegral Inner Membrane BBinoutin/outIM (predicted)Membrane | Single-pass membrane protein-SRPSECnoyesN310.097CYT0-0.200913-110i20-38oUnknown2
TISB_ECOLIA5A627
tisB

ysdB

ysdBb4618 JW3649 Small toxic protein tisB (LexA-regulated protein tisB)Cell inner membranePotentially toxic protein.PMID: 19121005 PMID: 18761622Integral Inner Membrane BBinoutout/inIM (predicted)Cell inner membrane | Single-pass membrane protein-SRPSECpseudogene (Uniprot), pseudogene (Ecogene)nonoN230.099CYT0-0.200913-110o6-25iUnknown2
YTCA_ECOLIA5A630
ytcA
b4622 Uncharacterized protein ytcAIntegral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Lipid-anchorMembrane | Multi-pass membrane proteinIntegral Membrane ProteinSECnoyesN330.139TMH010.1309-22Yn16-27c32/33o42-61i68-90oCytoplasmicMembrane10
YTHA_ECOLIA8DYQ1
ythA
b4655 JW5769.1 Uncharacterized protein ythASmall membrane protein detected experimentallyPMID: 19121005Integral Inner Membrane BBinin/outN/ACell membrane | Single-pass membrane protein-SECnoyesN410.12CYT0-0.200913-110i21-40oCytoplasmicMembrane9.82
YKGR_ECOLIC1P5Z8
ykgR
b4671 JW5035.1 Uncharacterized membrane protein ykgRIntegral inner membrane (experimental).Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(in)-C(out).PMID: 19121005 PMID: 21778229Integral Inner Membrane BBinoutin/outN/AMembrane | Single-pass membrane protein-SRPSECnoyesN210.096CYT0-0.200913-110i12-30oUnknown2
YMIB_ECOLIC1P5Z9
ymiB
b4672 JW1278.1 Putative protein ymiBIntegral Inner Membrane BBinoutin/outN/AMembrane | Single-pass membrane protein-SRPSECnoyesN280.1CYT0-0.200913-110i12-29oUnknown2
YOAK_ECOLIC1P602
yoaK
b4676 JW5292.1 Inner membrane protein ybhIInner membrane (experimental). Inner membrane (experimental).Found to co-fractionate with the inner membrane. Can be inserted in both orientations (Cout-Nin and Cin-Nout). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased.PMID: 19121005 PMID: 21778229 PMID: 21778229 PMID: 21778229Integral Inner Membrane BBinout, Bmultiin/out, out/inN/AMembrane | Single-pass membrane protein-SRPYidCnoyesN290.152TMH03.55641-110o6-29iCytoplasmicMembrane9.82
YOAJ_ECOLIC1P603
yoaJ
b4675 JW5292.2 Uncharacterized protein YoaJInner Membrane.Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(in)-C(out). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased.PMID: 19121005 PMID: 21778229 PMID: 21778229Integral Inner Membrane BBinoutin/outN/AMembrane | Single-pass membrane protein-SRPYidCnoyesN190.098CYT0-0.200913-110o6-23iCytoplasmicMembrane9.82
YOHP_ECOLIC1P609
yohP
b4679 JW5358.1 Inner membrane transport protein ydiMIntegral inner membrane (experimental). Integral inner membrane (experimental).Found to co-fractionate with the inner membrane. Can be inserted in both orientations (Cout-Nin and Cin-Nout).PMID: 19121005 PMID: 21778229Integral Inner Membrane BBinout, Bmultiin/out, out/inN/AMembrane | Single-pass membrane protein-SRPSECnoyesN250.1TMH00.568556-110o6-26iCytoplasmicMembrane9.82
YPDK_ECOLIC1P610
ypdK
b4680 JW2375.1 Uncharacterized transporter YeaVOuter membrane Inner membrane.Found to co-fractionate with the inner membrane.PMID: 19121005 PMID: 21778229Integral Inner Membrane BBinoutout/inN/AMembrane | Single-pass membrane protein-SRPSECnoyesN170.106CYT0-0.200913-110o6-22iCytoplasmicMembrane9.82
SHOB_ECOLIC1P611
shoB

ryfB yphI

ryfB yphIb4687 JW2546.1 IlvBN operon leader peptide (IlvBN operon attenuator peptide)Inner membranePMID: 19121005 PMID: 18710431Integral Inner Membrane BBinoutin/outN/AMembrane | Single-pass membrane protein-SRPSECnoyesN130.098CYT0-0.200913-110i7-25oCytoplasmicMembrane9.82
YQFG_ECOLIC1P614
yqfG
b4684 JW5470.1 Uncharacterized protein yqfGSmall protein detected experimentally.PMID: 19121005Integral Inner Membrane B-N/A-SRPSECnoyesN240.133TMH02.01664-10Yn7-17c29/30oCytoplasmicMembrane9.82
IBSD_ECOLIC1P616
ibsD
b4664 JW3023.1 Autoinducer 2 import system permease protein lsrD (AI-2 import system permease protein lsrD)Belongs to the toxic protein ibs family. Potentially toxic protein.PMID: 19121005Integral Inner Membrane B-N/AMembrane | Single-pass membrane protein-SECnoyesN180.098CYT0-0.200913-10Yn4-9c13/14oCytoplasmicMembrane9.82
PMRR_ECOLIG3MTW7
pmrR
b4703 JW4072.1Putative membrane protein PmrR Integral Inner Membrane BBoutin/outN/ASECno1Unknown2
PHSM_ECOLIP00490
malP
b3417 JW5689 Maltodextrin phosphorylase (EC 2.4.1.1)Peripheral inner membrane protein facing the cytoplasm (potential).PMID: 15919657Integral Inner Membrane B-Soluble IM FractionCytoplasmicSECyesyesN540.131CYT0-0.200913-000iCytoplasmic9.97
PTM3C_ECOLIP00550
mtlA
b3599 JW3573 PTS system mannitol-specific EIICBA component (EIICBA-Mtl) (EII-Mtl) [Includes: Mannitol permease IIC component (PTS system mannitol-specific EIIC component); Mannitol-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system mannitol-speInner membrane (experimental). Integral inner membrane (experimental). Inner membrane (experimental). Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. The signal anchor sequence of MtlA confers novel properties onto nascent chains of OmpA of being co-translationally recognized and targeted to SecY by SRP. PMCID: PMC305875 The signal anchor sequence of MtlA confers novel properties onto nascent chains of OmpA of being co-translationally recognized and targeted to SecY by SRP. Once targeted to SecY, ribosome-associated nascent chains of the hybrid protein, however, remain untranslocated unless SecA is present. These results indicate that SRP and SecA cooperate in a sequential, non-overlapping manner. PMCID: PMC305875PMID: 9008159 PMID: 15919657 PMID: 15919996 PMID: 9260961 PMCID: PMC305875Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN230.115TMH011.9934-880i20-42o48-66i78-98o133-154i161-181o213-234i269-292o312-334iCytoplasmicMembrane1026.94
LEP_ECOLIP00803
lepB
b2568 JW2552 Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I)Integral inner membrane (experimental). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased. Lep was shown to be targeted to the membrane by the SRP pathway. PMID: 8985168 Disulfide bridge (171 177) PMID: 2551889 PMID: 21778229 PMID: 15919996 PMID: 8985168 Integral Inner Membrane Bout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinYidCyesyesN220.131SpII203.04951Pos+2=V20Yn5-16c21/22oCytoplasmicMembrane1027.67
LSPA_ECOLIP00804
lspA
b0027 JW0025 Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II)Cell inner membrane Integral inner membrane (experimental).Catalyzes the removal of signal peptides from prolipoproteins.PMID: 6378662 PMID: 6368552 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN360.135TMH07.83163-440i12-31o70-88i100-117o137-157iCytoplasmicMembrane105.54
MALF_ECOLIP02916
malF
b4033 JW3993 Maltose transport system permease protein malFCell inner membrane, Periplasmic side Integral inner membrane (experimental). Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. Crystal structure of a catalytic intermediate of the maltose transporter. PMID: 18033289 Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 9008159 PMID: 18456666 PMID: 15919996 PMID: 18033289 PMID: 25403562 PMID: 25403562Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane protein | Periplasmic sideIntegral Membrane ProteinSRP (exp)SECYfgMnoyesN650.175TMH014.2023-880i14-34o40-58i67-91o277-303i315-340o371-392i426-447o484-506iCytoplasmicMembrane10
PBPA_ECOLIP02918
mrcA

ponA

ponAb3396 JW3359 Penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.2.-) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.-.-) (DD-transpeptidase)]Inner membrane (experimental). Membrane anchoredThe formation of a complex between a murein polymerase (PBP1B) and a murein hydrolase (MltA) in the presence of MipA represents a first step in a reconstitution of the hypothetical murein-synthesizing holoenzyme, postulated to be responsible for controlled growth of the stress-bearing sacculus of E. coli. The two OM lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase activity, thereby facilitating attachment of new peptidoglycans to the PG sacculus. Uniprot annotation is Cell inner membrane; Single-pass type II membrane protein, Gene Ontology and Echolocation annotation is Membrane anchored. PMID: 3510188PMID: 10037771 PMID: 21183073 PMID: 15919657 PMID: 3510188Integral Inner Membrane BBoutin/outSoluble IM FractionCell inner membrane | Single-pass type II membrane proteinMembrane anchored (Experimental)SRPSECyesyesN250.144TMH02.26474-10Yn7-17c24/25oCytoplasmicMembrane104.59
GSPB_ECOLIP03825
gspB

pinO pioO pno

pinO pioO pnob3322 JW3284 Putative general secretion pathway protein BIntegral Inner Membrane BBinout/inIM (predicted)Membrane anchoredSRPSECnoyesN430.123TMH03.27755-110o28-51iUnknown2
PBPB_ECOLIP02919
mrcB

pbpF ponB

pbpF ponBb0149 JW0145 Penicillin-binding protein 1B (PBP-1b) (PBP1b) (Murein polymerase) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase) (Peptidoglycan glycosyltransferase); Penicillin-sensitive transpeptidase (EC 3.4.-.-) (DD-transpeptiInner membrane (experimental).The two OM lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase activity, thereby facilitating attachment of new peptidoglycans to the PG sacculus. Cell inner membrane; Single-pass type II membrane protein. Monoisotopic peripheral; Contains amphipathic a-helix.PMID: 19458048 PMID: 21183073 PMID: 15919657Integral Inner Membrane BBoutin/outIM (predicted), Detected in IM FractionCell inner membrane | Single-pass type II membrane proteinMembrane anchoredSRPSECyesyesN30.105CYT0-0.200913-110i65-86oCytoplasmicMembrane10
LACY_ECOLIP02920
lacY
b0343 JW0334 Lactose permease (Lactose-proton symport) Integral inner membrane (experimental). Integral inner membrane (experimental).Crystal structure of lactose permease indicated that the molecule is composed of N- and C-terminal domains, each with six transmembrane helices, symmetrically positioned within the permease PMID: 12893935.PMID: 11266632 PMID: 12893935 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.125TMH018.848-11120i12-34o46-66i75-95o101-122i143-162o168-187i222-239o259-279i291-310o316-337i349-369o381-401iCytoplasmicMembrane10
MELB_ECOLIP02921
melB

mel-4

mel-4b4120 JW4081 Melibiose carrier protein (Melibiose permease) (Melibiose transporter) (Na+ (Li+)/melibiose symporter) (Thiomethylgalactoside permease II)Cell inner membrane Integral inner membrane (experimental).PMID: 7703254 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN180.118TMH08.17946-12120i12-31o37-57i78-100o106-130i150-171o177-198i236-258o270-290i297-318o324-353i374-397o409-432iCytoplasmicMembrane10
PPDB_ECOLIP08371
ppdB

ygdC

ygdCb2825 JW5451 Prepilin peptidase-dependent protein BIntegral Inner Membrane BBinout/inIM (predicted)Membrane anchoredSRPSECyesyesN360.136CYT0-0.200913-110o13-34iUnknown223.18
PPDC_ECOLIP08372
ppdC

ygdA

ygdAb2823 JW2791 Prepilin peptidase-dependent protein CIntegral Inner Membrane BBinout/inIM (predicted)Membrane anchoredSRPSECyesyesN300.122TMH06.3414-110o16-33iUnknown224.18
CVPA_ECOLIP08550
cvpA

dedE

dedEb2313 JW2310 Colicin V production protein (Protein dedE) (Pur regulon 18 kDa protein)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN310.117TMH06.39839-440o6-25i32-52o64-87i99-120oCytoplasmicMembrane10
TONB_ECOLIP02929
tonB

exbA

exbAb1252 JW5195 Protein tonBIntegral inner membrane protein.PMID: 11967085Integral Inner Membrane BBoutin/outN/ACell inner membrane | Single-pass membrane protein | Periplasmic sideMembrane anchoredSECyesyesN430.176TMH03.06055-010i12-32oUnknown2
MCP1_ECOLIP02942
tsr

cheD

cheDb4355 JW4318 Methyl-accepting chemotaxis protein I (MCP-I) (Serine chemoreceptor protein)Cell inner membrane Integral inner membrane (experimental).PMID: 22380631 PMID: 15919996Integral Inner Membrane BBinoutout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.141SpI255.90497-21Yn10-21c26/27o192-214iCytoplasmicMembrane1044.19
KEFC_ECOLIP03819
kefC

trkC

trkCb0047 JW0046 Glutathione-regulated potassium-efflux system protein kefC (K(+)/H(+) antiporter)Cell inner membrane Integral inner membrane (experimental).PMID: 2046548 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN340.112TMH07.67646-13130o6-24i31-49o55-72i84-111o117-135i147-169o181-202i214-233o239-258i270-290o296-315i327-348o360-378iCytoplasmicMembrane10
ATKA_ECOLIP03959
kdpA
b0698 JW0686 Potassium-transporting ATPase A chain (EC 3.6.3.12) (ATP phosphohydrolase [potassium-transporting] A chain) (Potassium-binding and translocating subunit A) (Potassium-translocating ATPase A chain)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN210.183TMH00.239367-1212Yn5-16c20/21o59-82i94-115o135-155i167-190o253-271i283-301o327-349i356-374o380-398i418-437o484-505i526-548oCytoplasmicMembrane1010.15
FTSB_ECOLIP0A6S5
ftsB

ygbQ

ygbQb2748 JW2718 Cell division protein ftsBCell inner membrane Cell inner membranePMID: 11972052 PMID: 15165235Integral Inner Membrane BBoutout/inIM (predicted)Cell inner membrane | Single-pass type II membrane proteinMembrane anchoredSRPSECyesyesN230.157CYT0-0.200913-10Yn4-14c18/19oCytoplasmicMembrane9.8225.62
ISPZ_ECOLIP0A710
yciB

ispZ

ispZb1254 JW1246 Probable intracellular septation proteinIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.173TMH07.58982-550o20-39i51-68o74-96i117-139o151-170iCytoplasmicMembrane10
RNFA_ECOLIP0A766
rnfA

ydgL

ydgLb1627 JW1619 Electron transport complex protein rnfAIntegral inner membrane (experimental).PMID: 15919996 PMID: 24688744Integral Inner Membrane BBpoly, Bmultiout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein(experimental)SRPSECyesyesN210.118TMH07.31415-660o6-26i38-59o65-87i99-122o134-155i167-191oCytoplasmicMembrane10
ATKB_ECOLIP03960
kdpB
b0697 JW0685 Potassium-transporting ATPase B chain (EC 3.6.3.12) (ATP phosphohydrolase [potassium-transporting] B chain) (Potassium-binding and translocating subunit B) (Potassium-translocating ATPase B chain)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN550.195CYT0-0.200913-760i35-56o62-82i219-240o252-274i616-636o656-681iCytoplasmicMembrane108.13
ATKC_ECOLIP03961
kdpC
b0696 JW0684 Potassium-transporting ATPase C chain (EC 3.6.3.12) (ATP phosphohydrolase [potassium-transporting] C chain) (Potassium-binding and translocating subunit C) (Potassium-translocating ATPase C chain)Integral Inner Membrane BBoutin/outN/ACell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN390.2TMH011.3621-10Yn7-18c30/31oCytoplasmicMembrane1018.2
MCP3_ECOLIP05704
trg
b1421 JW1417 Methyl-accepting chemotaxis protein III (MCP-III) (Ribose and galactose chemoreceptor protein)Cell inner membrane Integral inner membrane (experimental).PMID: 22380631 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN400.259TMH07.8524-220i20-44o199-222iCytoplasmicMembrane1034.19
FTSQ_ECOLIP06136
ftsQ
b0093 JW0091 Cell division protein ftsQCell inner membrane Cell inner membrane Cell inner membrane Cell inner membrane Cell inner membrane Cell inner membrane Cell inner membrane Cell inner membrane FtsQ could be localized to the division site in constricting cells. FtsQ insertion requires SecYEG, the transmembrane electrical potential, SecA, and the SRP pathway. PMID: 15546656 YidC plays a role in the membrane integration of the FtsQ protein as the hydrophobic region of FtsQ can be cross-linked to YidC. PMID: 15546656PMID: 2007547 PMID: 9829918 PMID: 9882666 PMID: 11415986 PMID: 11703663 PMID: 11948172 PMID: 15165235 PMID: 17693520 PMID: 15546656 PMID: 15546656Integral Inner Membrane BBoutin/outIM (predicted)Cell inner membrane | Single-pass type II membrane proteinMembrane anchoredSRPSECyesyesN410.115TMH01.18618-110i25-49oUnknown224.26
PSIE_ECOLIP0A7C8
psiE

yjbA

yjbAb4030 JW3990 Protein psiEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN430.143TMH04.00332-440i12-35o55-74i86-105o111-128iCytoplasmicMembrane10
TATE_ECOLIP0A843
tatE

ybeC

ybeCb0627 JW0622 Sec-independent protein translocase protein tatETatA paralog TatE can substitute for TatA and support translocation of Tat substrates including AmiA, AmiC, and TorA.PMID: 22190680Integral Inner Membrane BBoutout/inIM (predicted), Detected in IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN430.118CYT0-0.200913-10Yn9-20c29/30oCytoplasmicMembrane9.82127.03
YFBV_ECOLIP0A8D9
yfbV
b2295 JW2292 UPF0208 membrane protein yfbVIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN230.122CYT0-0.200913-220i46-64o70-90iCytoplasmicMembrane1038.96
BTUC_ECOLIP06609
btuC
b1711 JW1701 Vitamin B12 import system permease protein BtuC Integral inner membrane (experimental). Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 11266632 PMID: 12004122 PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN340.278TMH013.5896-99Yn16-29c34/35o58-77i89-109o115-133i145-168o188-206i213-232o238-262i274-297o303-322iCytoplasmicMembrane10
BIRA_ECOLIP06709
birA

bioR dhbB

bioR dhbBb3973 JW3941 Bifunctional protein BirA [Includes: Biotin operon repressor; Biotin--[acetyl-CoA-carboxylase] synthetase (EC 6.3.4.15) (Biotin--protein ligase)]. Deletion of BioR resulted in a 15-fold increase of bio operon transcription in the presence of high biotin levels.Nucleoid (experimental).PMID: 23138451 PMID: 23387333Nucleoid, Integral Inner Membrane N, BIM (predicted)CytoplasmicSRPSECyesyesN260.122CYT0-0.200913-020i123-139o145-162iCytoplasmic1037.71
FHUB_ECOLIP06972
fhuB
b0153 JW0149 Iron(3+)-hydroxamate import system permease protein fhuB (Ferric hydroxamate uptake protein B) (Ferrichrome transport system permease protein fhuB) (Ferrichrome uptake protein fhuB) (Iron(III)-hydroxamate import system permease protein fhuB)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.415TMH012.8147-1717Yn5-20c38/39o62-79i91-111o117-137i144-167o194-212i224-241o247-265i277-299o305-326i347-369o389-411i423-443o449-468i480-499o567-594i606-623o635-655iCytoplasmicMembrane10
PNTA_ECOLIP07001
pntA
b1603 JW1595 NAD(P) transhydrogenase subunit alpha (EC 1.6.1.2) (Nicotinamide nucleotide transhydrogenase subunit alpha) (Pyridine nucleotide transhydrogenase subunit alpha)Integral inner membrane (experimental). Integral Membrane Protein Integral Membrane Protein Integral Membrane ProteinPMID: 14660605 PMID: 15919996 PMID: 3525165 PMID: 3525165 PMID: 1932078Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN400.111CYT0-0.200913-540i400-418o424-443i455-472o478-499iCytoplasmicMembrane10110.88
USPB_ECOLIP0A8S5
uspB

yhiO

yhiOb3494 JW3461 Universal stress protein BIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.13TMH00.843073-220o6-24i90-110oCytoplasmicMembrane1057.89
ESSD_ECOLIP0A9R2
essD

ybcR

ybcRb0554 JW0543 Lysis protein S homolog from lambdoid prophage DLP12Integral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)yesnoN380.193CYT0-0.200913-220i7-25o37-58iUnknown214.71
MCP2_ECOLIP07017
tar

cheM

cheMb1886 JW1875 Methyl-accepting chemotaxis protein II (MCP-II) (Aspartate chemoreceptor protein)Integral inner membrane (experimental). Integral inner membrane (experimental). Integral Membrane Protein Integral Membrane Protein Integral Membrane ProteinPole-derived membrane fragments were isolated by affinity capture of vesicles containing the chemotaxis protein, Tar. PMID: 3049536 PMID: 12826616 PMID: 12826616 PMID: 17144658PMID: 22380631 PMID: 15919996 PMID: 3049536 PMID: 12826616 PMID: 17144658Integral Inner Membrane BBinoutout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN200.158TMH04.99054-21Yn10-21c26/27o192-212iCytoplasmicMembrane1073.56
MCP4_ECOLIP07018
tap
b1885 JW1874 Methyl-accepting chemotaxis protein IV (MCP-IV) (Dipeptide chemoreceptor protein)Cell inner membrane Integral inner membrane (experimental).PMID: 22380631 PMID: 15919996Integral Inner Membrane BBinoutout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN350.179TMH06.20402-21Yn10-21c34/35o187-209iCytoplasmicMembrane105.39
PUTP_ECOLIP07117
putP
b1015 JW1001 Sodium/proline symporter (Proline permease) (Propionate transporter)Cell inner membrane Integral inner membrane (experimental). Integral Membrane ProteinPMID: 16079137 PMID: 15919996 PMID: 3302614Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN280.128TMH013.7134-12120i7-26o66-88i127-152o164-186i193-213o233-256i277-296o325-350i371-391o403-422i429-449o455-473iCytoplasmicMembrane10
PSTA_ECOLIP07654
pstA

phoT

phoTb3726 JW3704 Phosphate transport system permease protein pstAIntegral Inner membrane (experimental). Integral Inner membrane (experimental).PMID: 3881386 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN140.135TMH014.9057-660i29-50o89-111i123-145o151-169i201-222o267-290iCytoplasmicMembrane10
YMCE_ECOLIP0AAA5
sfa

sfa

sfab0991 JW0975 Protein sfaIntegral Inner Membrane BBoutin/outN/ACell membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN460.141TMH04.44945-10Yn15-25c29/30oUnknown2100.09
YAIY_ECOLIP0AAP7
yaiY
b0379 JW0370 Inner membrane protein yaiYIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.177TMH0-0.122448-220i25-48o68-95iCytoplasmicMembrane1039.97
YAIZ_ECOLIP0AAQ0
yaiZ
b0380 JW5053 Uncharacterized protein yaiZIntegral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN180.115TMH06.70305-220i12-32o38-59iCytoplasmicMembrane9.8272.46
GLPT_ECOLIP08194
glpT
b2240 JW2234 Glycerol-3-phosphate transporter (G-3-P transporter) (G-3-P permease) Integral inner membrane (experimental).PMID: 11266632 PMID: 12893935 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN520.128CYT0-0.200913-12120i26-44o64-82i94-113o119-138i159-183o189-208i254-272o292-311i323-342o348-373i385-405o417-437iCytoplasmicMembrane10
CRED_ECOLIP08369
creD

cet

cetb4400 JW4363 Inner membrane protein creDIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCnoyesN290.114TMH04.58166-65Yn11-22c34/35o295-313i325-343o349-368i375-396o402-420iCytoplasmicMembrane1028.1
SPPA_ECOLIP08395
sppA
b1766 JW1755 Protease 4 (EC 3.4.21.-) (Endopeptidase IV) (Protease IV) (Signal peptide peptidase)Cell inner membrane Cell inner membranePMID: 3522590 PMID: 18476724Integral Inner Membrane BBoutin/outIM (predicted), Detected in IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN480.115TMH06.31524-110i21-43oCytoplasmicMembrane1014.1
PHOR_ECOLIP08400
phoR

nmpB

nmpBb0400 JW0390 Phosphate regulon sensor protein phoR (EC 2.7.13.3)Integral Inner Membrane Integral inner membrane (experimental).PMID: 2187152 PMID: 15919996Integral Inner Membrane BBpolyin/inN/ACell inner membrane | Multi-pass membrane proteinMembrane anchoredSRPSECyesyesN240.17TMH020.4877-120i12-36o42-59iCytoplasmicMembrane1013.24
YBAN_ECOLIP0AAR5
ybaN
b0468 JW0457 Inner membrane protein ybaNIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN490.172TMH011.6864-440i5-25o31-52i73-91o97-115iCytoplasmicMembrane1015.92
YLAC_ECOLIP0AAS0
ylaC
b0458 JW5063 Inner membrane protein ylaCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN510.106CYT0-0.200913-220i36-55o61-79iCytoplasmicMembrane1060.78
YBFA_ECOLIP0AAU2
ybfA
b0699 JW0688 Uncharacterized protein ybfAIntegral Inner Membrane BBinout/inIM (predicted)Membrane anchoredSRPSECnoyesN220.331TMH02.48449-110o12-33iCytoplasmicMembrane9.8212.53
CREC_ECOLIP08401
creC

phoM

phoMb4399 JW4362 Sensor protein creC (EC 2.7.13.3)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBinoutout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN250.159SpI27-0.123855-21Yn7-18c24/25o184-206iCytoplasmicMembrane1016.29
DSDX_ECOLIP08555
dsdX

yfdA yfdD

yfdA yfdDb2365 JW2362 DsdX permeaseIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN330.118TMH011.5143-12120o6-23i30-47o59-77i98-128o140-158i178-198o225-244i256-282o302-322i343-365o385-408i420-444oCytoplasmicMembrane1012.2
PTV3B_ECOLIP08722
bglF

bglC bglS

bglC bglSb3722 JW3700 PTS system beta-glucoside-specific EIIBCA component (EIIBCA-Bgl) (EII-Bgl) [Includes: Beta-glucoside-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system beta-glucoside-specific EIIB component); Beta-glucoside permease IIC component Integral inner membrane (experimental).In the absence of β-glucosidase, associates with BglG to form a pro-form membrane complex that maintains BglG inactive.PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN410.16CYT0-0.200913-10120i100-121o141-160i172-190o210-230i242-263o269-292i299-322o328-347i354-375o381-400i407-424o430-452iCytoplasmicMembrane10
HEMX_ECOLIP09127
hemX
b3803 JW3775 Putative uroporphyrinogen-III C-methyltransferase (Urogen-III methylase) (EC 2.1.1.107) (ORF X)Cell inner membranePMID: 16079137Integral Inner Membrane BBoutin/outIM (predicted), Detected in IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN500.207CYT0-0.200913-110i36-57oCytoplasmicMembrane10
YBFB_ECOLIP0AAU5
ybfB
b0702 JW0691 Uncharacterized protein ybfBIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN290.135TMH015.1783-330o6-24i45-68o80-101iCytoplasmicMembrane1035.03
YBGE_ECOLIP0AAV0
ybgE
b0735 JW0725 Uncharacterized protein ybgEIntegral Inner Membrane BBpolyout/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN410.437TMH03.17076-330o17-34i46-67o73-96iCytoplasmicMembrane1027.21
YBHQ_ECOLIP0AAW5
ybhQ
b0791 JW0774 Inner membrane protein ybhQIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.117TMH07.89577-440i12-32o38-58i79-96o102-120iCytoplasmicMembrane10
PTW3C_ECOLIP09323
nagE

pstN

pstNb0679 JW0665 PTS system N-acetylglucosamine-specific EIICBA component (EIICBA-Nag) (EII-Nag) [Includes: N-acetylglucosamine permease IIC component (PTS system N-acetylglucosamine-specific EIIC component); N-acetylglucosamine-specific phosphotransferase enzyme IIB compInner membrane (experimental). Integral inner membrane (experimental).PMID: 15919657 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN450.132TMH03.42438-10120i12-32o38-61i68-88o94-112i132-153o165-185i192-212o232-252i259-276o282-306i313-331o337-359iCytoplasmicMembrane101.97
MOTA_ECOLIP09348
motA

flaJ

flaJb1890 JW1879 Motility protein A (Chemotaxis protein MotA)Integral inner membrane (experimental).Interacts with flagellar brake protein YcgR in the flagellar basal bodies or FliM or FliG.PMID: 20303158 PMID: 20346719 PMID: 19364805 PMID: 23193105 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.167TMH04.42407-44Yn2-11c16/17o32-49i70-87o171-189i201-220oCytoplasmicMembrane1018.62
GLPG_ECOLIP09391
glpG
b3424 JW5687 Rhomboid protease glpG (EC 3.4.21.105) (Intramembrane serine protease) Integral inner membrane (experimental). Intramembrane Protease (experimental). Integral inner membrane (experimental).Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 11266632 PMID: 17051161 PMID: 16216077 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN160.202CYT0-0.200913-660i96-115o135-160i172-188o194-212i224-242o248-267iCytoplasmicMembrane10
DEDD_ECOLIP09549
dedD
b2314 JW5378 Protein dedD. DedD is a cell division protein; it contains a C-terminal SPOR domain which targets the protein to the septal ring.Integral Inner Membrane BBoutin/outIM (predicted), Detected in IM FractionMembrane anchoredSRPSECyesyesN300.117SpI270.354359-110i9-27oUnknown2
YBHT_ECOLIP0AAW9
ybhT
b0762 JW5102 Bacteriophage N4 adsorption protein BSmall membrane protein (experimental). Outer membrane.Experimentally verified orientation: N(out)-C(in). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased.PMID: 19121005 PMID: 21778229Integral Inner Membrane BBoutin/outIM (predicted)Membrane | Single-pass membrane proteinMembrane anchoredSRPYidCnoyesN210.157TMH01.49031-110i7-29oCytoplasmicMembrane9.8228.74
YBJO_ECOLIP0AAZ0
ybjO
b0858 JW0842 Inner membrane protein ybjOIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN180.159TMH04.12536-440i21-44o64-87i94-111o131-151iCytoplasmicMembrane1032.79
YCCF_ECOLIP0AB12
yccF
b0961 JW0944 Inner membrane protein yccFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN240.116TMH02.25765-330i7-33o69-90i102-123oCytoplasmicMembrane10
UHPB_ECOLIP09835
uhpB
b3668 JW3643 Sensor protein uhpB (EC 2.7.13.3)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.141TMH016.0266-790o6-28i40-60o80-100i112-132o138-162i183-201o207-224i231-249o255-273iCytoplasmicMembrane1019.08
UHPC_ECOLIP09836
uhpC
b3667 JW3642 Regulatory protein uhpCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN520.143CYT0-0.200913-12120i26-45o65-84i96-114o120-143i155-179o185-203i245-265o285-308i320-338o344-365i377-401o407-431iCytoplasmicMembrane10
UBIB_ECOLIP0A6A0
ubiB

aarF yigQ yigR yigS

aarF yigQ yigR yigSb3835 JW3812 Probable ubiquinone biosynthesis protein ubiBCell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN500.114CYT0-0.200913-220i501-518o524-542iCytoplasmicMembrane1017.98
CLSA_ECOLIP0A6H8
clsA

cls nov yciJ

cls nov yciJb1249 JW1241 Cardiolipin synthase (CL synthase) (EC 2.7.8.-)Cell inner membrane In E. coli, the cls and ybhO genes (renamed clsA and clsB, respectively) each encode a CL (cardiolipin) synthase (Cls) that catalyzes the condensation of two PG molecules to form CL and glycerol. PMID: 22988102PMID: 15919996 PMID: 22988102Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN220.149TMH05.41966-220o6-25i37-58oCytoplasmicMembrane103.69
YCFJ_ECOLIP0AB35
ycfJ
b1110 JW1096 Uncharacterized protein ycfJIntegral Inner Membrane B-N/AMembrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN360.275SpI238.09735-10Yn6-17c21/22oUnknown2.5
YCHH_ECOLIP0AB49
ychH
b1205 JW1196 Uncharacterized protein ychHIntegral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN440.123TMH012.8445-220i12-29o41-59iCytoplasmicMembrane9.8273.18
ATPZ_ECOLIP0ABC0
atpI

uncI

uncIb3739 JW5611 ATP synthase protein IIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN640.113TMH04.01303-43Yn14-25c30/31o40-59i71-94o100-122iCytoplasmicMembrane1034.91
CYSZ_ECOLIP0A6J3
cysZ
b2413 JW2406 Protein cysZIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC. PMID: 15919996PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPYidCyesyesN180.111TMH05.82324-450i31-51o71-92i143-163o169-188i209-242oCytoplasmicMembrane1019.52
DSBB_ECOLIP0A6M2
dsbB

roxB ycgA

roxB ycgAb1185 JW5182 Disulfide bond formation protein B (Disulfide oxidoreductase)Integral inner membrane (experimental). Alpha-helcal transmembrane protein (experimental). Integral inner membrane (experimental). Integral inner membrane (experimental). Exhibites aberrant localization by microscopy in the absence of YidC PMID: 22108384. The crystal structure revealed a transmembrane (TM) four-helix-bundle structure of DsbBPMID: 18406599. DsbB oxidizes the periplasmic protein DsbA, which in turn oxidizes the cysteines in other periplasmic proteins to make disulfide bondsPMID: 8430071. Gene fusion approaches were used to show that (i) DsbB is a membrane protein which spans the membrane four times and (ii) both the N- and C-termini of the protein are in the cytoplasmPMID: 7957076. The structure of DsbB revealed four transmembrane helices and one short horizontal helix juxtaposed with Cys130 in the mobile periplasmic loopPMID: 17110337. Disulfide bridge (41 44;104 130) PMID: 10064586PMID: 18406599 PMID: 11266632 PMID: 17110337 PMID: 22108384 PMID: 8430071 PMID: 7957076 PMID: 15919996 PMID: 10064586Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN250.286TMH04.8983-440i12-33o45-64i71-89o145-166iCytoplasmicMembrane1015.79
MRAY_ECOLIP0A6W3
mraY

murX

murXb0087 JW0085 Phospho-N-acetylmuramoyl-pentapeptide-transferase (EC 2.7.8.13) (UDP-MurNAc-pentapeptide phosphotransferase)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.151CYT0-0.200913-10100o20-40i73-90o96-114i134-152o172-193i200-219o239-256i263-284o290-311i338-357oCytoplasmicMembrane10
KDGT_ECOLIP0A712
kdgT
b3909 JW5560 2-keto-3-deoxygluconate permease (KDG permease)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN670.134TMH012.8678-10100i12-29o35-57i78-97o103-127i139-164o170-187i194-211o223-243i255-274o286-309iCytoplasmicMembrane10
MRED_ECOLIP0ABH4
mreD
b3249 JW3218 Rod shape-determining protein mreDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.118TMH015.556-550o6-25i37-54o74-92i104-128o134-152iCytoplasmicMembrane10
CYOD_ECOLIP0ABJ6
cyoD
b0429 JW0419 Cytochrome o ubiquinol oxidase protein cyoD (Ubiquinol oxidase chain D)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN440.15TMH014.0581-330o18-37i44-68o80-100iCytoplasmicMembrane10
CCMD_ECOLIP0ABM5
ccmD

yojM

yojMb2198 JW2186 Heme exporter protein D (Cytochrome c-type biogenesis protein CcmD)Integral Inner Membrane BBinoutout/inIM (predicted)Cell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN70.153TMH03.24028-110o12-37iCytoplasmicMembrane9.8266.64
EXBD_ECOLIP0ABV2
exbD
b3005 JW2973 Biopolymer transport protein exbDIntegral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell inner membrane | Single-pass type II membrane proteinMembrane anchoredSRPSECyesyesN420.15TMH00.162291-110o20-41iCytoplasmicMembrane9.9747.5
MSCL_ECOLIP0A742
mscL

yhdC

yhdCb3291 JW3252 Large-conductance mechanosensitive channelCell inner membrane Integral inner membrane (experimental).PMID: 17113597 PMID: 22108384 PMID: 8890153 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPYidCyesyesN390.143CYT0-0.200913-220i21-52o72-96iCytoplasmicMembrane1066.67
MNTH_ECOLIP0A769
mntH

yfeP

yfePb2392 JW2388 Manganese transport protein mntHCell inner membrane Integral inner membrane (experimental).PMID: 14607838 PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN280.129TMH09.54648-11110i21-40o52-75i95-116o122-144i156-176o196-216i237-263o283-313i325-343o349-370i391-410oCytoplasmicMembrane10
GPMB_ECOLIP0A7A2
gpmB

ytjC

ytjCb4395 JW4358 Probable phosphoglycerate mutase gpmB (EC 5.4.2.1) (PGAM) (Phosphoglyceromutase)Large potential TM 146-168aaIntegral Inner Membrane BBinoutout/inN/AMembrane anchoredSRPSECnoyesN170.117CYT0-0.200913-110o146-168iCytoplasmic9.9756.14
DCTA_ECOLIP0A830
dctA
b3528 JW3496 Aerobic C4-dicarboxylate transport proteinIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCnoyesN190.136TMH05.74612-880i9-27o47-64i76-99o141-164i184-208o220-242i326-344o350-373iCytoplasmicMembrane10
ZUPT_ECOLIP0A8H3
zupT

ygiE

ygiEb3040 JW3008 Zinc transporter zupTIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN590.198TMH010.378-670o6-25i32-50o62-81i125-150o170-192i199-215o235-256iCytoplasmicMembrane1027.87
TOLR_ECOLIP0ABV6
tolR
b0738 JW0728 Protein tolRMembrane anchoredPMID: 7744737Integral Inner Membrane BBoutin/outIM (predicted)Cell inner membrane | Single-pass type II membrane proteinMembrane anchored (Experimental)SRPSECyesyesN370.197TMH00.527259-110i21-39oCytoplasmicMembrane9.8223.96
FLIL_ECOLIP0ABX8
fliL

cheC1 fla AI fla QI

cheC1 fla AI fla QIb1944 JW1928 Flagellar protein FliLIntegral Inner Membrane BBoutin/outSoluble IM FractionCell inner membrane | Single-pass membrane proteinOuter membrane LipoproteinSRPSECnoyesN430.268SpII2610.5269Pos+2=A110i14-35oCytoplasmicMembrane1035.39
FLIQ_ECOLIP0AC07
fliQ

flaQ

flaQb1949 JW1933 Flagellar biosynthetic protein FliQIntegral Inner Membrane BBinoutin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinBacterial flagellum basal bodyIntegral Membrane ProteinflagellumSRPSECnoyesN410.283TMH014.373-21Yn16-35c40/41o56-74iCytoplasmicMembrane1030.83
YIHY_ECOLIP0A8K8
yihY
b3886 JW3857 b2268UPF0761 membrane protein yihYCell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinCytoplasmicSRPSECyesyesN600.127CYT0-0.200913-670o39-61i73-91o103-120i141-160o180-200i212-234o240-266iCytoplasmicMembrane10
FRDC_ECOLIP0A8Q0
frdC
b4152 JW4113 Fumarate reductase subunit C (Fumarate reductase 15 kDa hydrophobic protein) Integral inner membrane (experimental). Integral inner membrane (experimental).Alpha-helcal transmembrane protein (experimental). Transmembrane helices: 3. N-terminal region is in cytoplasm. Helix A and B connected by very short turns to an interfacial helix (N51-L63)PMID: 24057063.PMID: 11266632 PMID: 10373108 PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN590.224TMH01.78374-330i26-48o68-88i109-130oCytoplasmicMembrane109.34
FRDD_ECOLIP0A8Q3
frdD
b4151 JW4112 Fumarate reductase subunit D (Fumarate reductase 13 kDa hydrophobic protein) Integral inner membrane (experimental). Integral inner membrane (experimental).Alpha-helcal transmembrane protein (experimental). Transmembrane helices: 3 PMID: 10373108.PMID: 11266632 PMID: 10373108 PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN520.162TMH015.5267-330i12-45o57-78i99-118oCytoplasmicMembrane107.09
YCJF_ECOLIP0A8R7
ycjF
b1322 JW1315 UPF0283 membrane protein ycjFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.1CYT0-0.200913-340i70-87o99-120i214-236o256-275iCytoplasmicMembrane1010.64
PGPB_ECOLIP0A924
pgpB
b1278 JW1270 Phosphatidylglycerophosphatase B (EC 3.1.3.27)Cell inner membrane, Cell outer membrane Integral inner membrane (experimental). Cell inner membrane, Cell outer membranePgpB protein has phosphatidyl glycerophosphate phosphatase activity higher in the cytoplasmic membrane, while it has phosphatidic acid and lysophosphatidic acid phosphatase activities higher in the outer membrane.PMID: 2846511 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinCell outer membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN240.144TMH017.4928-660i12-29o49-68i75-96o157-178i185-206o212-230iCytoplasmicMembrane10
YAAH_ECOLIP0AC98
yaaH
b0010 JW0009 Inner membrane protein yaaHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN340.122TMH09.07966-660i12-31o37-56i63-84o96-116i123-143o149-169iCytoplasmicMembrane10
YEAL_ECOLIP0ACY6
yeaL
b1789 JW1778 UPF0756 membrane protein yeaLIntegral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN250.203TMH08.39191-44Yn4-12c16/17o26-46i53-71o83-100i112-145oCytoplasmicMembrane10
YOHC_ECOLIP0AD17
yohC
b2135 JW5356 Inner membrane protein yohCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN450.135TMH02.03436-550i33-53o65-91i103-122o128-149i170-190oCytoplasmicMembrane1016.06
PLAP_ECOLIP0AA47
plaP

yeeF

yeeFb2014 JW5330 Inner membrane transport protein yeeFIntegral inner membrane (experimental).Old gene name YeeF.PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.148TMH08.96423-12120i20-42o54-73i94-116o128-146i158-179o199-217i237-260o287-315i336-355o361-383i395-413o419-437iCytoplasmicMembrane10
YFDV_ECOLIP0AA49
yfdV
b2372 JW2369 Uncharacterized transporter yfdVIntegral Membrane ProteinPMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN570.126CYT0-0.200913-10100o6-23i35-55o67-90i97-117o129-150i175-196o202-222i234-253o259-278i290-309oCytoplasmicMembrane10
QMCA_ECOLIP0AA53
qmcA

ybbK

ybbKb0489 JW0478 Protein QmcACell inner membranePMID: 16573693Integral Inner Membrane BBoutin/outIM (predicted), Detected in IM FractionCell inner membrane | Single-pass type I membrane proteinMembrane anchoredSRPSECyesyesN180.11TMH01.35378-10Yn2-13c18/19oUnknown213.53
YGHB_ECOLIP0AA60
yghB
b3009 JW2976 Inner membrane protein yghBIntegral inner membrane (experimental).Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF.PMID: 15919996 PMID: 23086209Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.338TMH00.0786812-460o20-38i45-62o68-88i123-143o155-176i188-212oCytoplasmicMembrane108.12
YQJA_ECOLIP0AA63
yqjA
b3095 JW3066 Inner membrane protein yqjAIntegral inner membrane (experimental).Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF.PMID: 15919996 PMID: 23086209Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein SRPSECyesyesN210.127TMH04.47784-660o20-38i45-62o68-88i123-143o155-176i188-212oCytoplasmicMembrane103.55
YOHK_ECOLIP0AD19
yohK
b2142 JW2130 Inner membrane protein yohKIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN240.211TMH01.42711-64Yn7-18c23/24o33-52i91-112o132-162i206-230oCytoplasmicMembrane10
YPHA_ECOLIP0AD47
yphA
b2543 JW2527 Inner membrane protein yphAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN580.13TMH013.6817-440i12-33o53-74i81-100o120-137iCytoplasmicMembrane10
YJJB_ECOLIP0ADD2
yjjB
b4363 JW4327 UPF0442 protein yjjB (Protein P-14)Integral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.153TMH07.02974-350o6-27i34-52o58-75i87-109o129-151iCytoplasmicMembrane1011.1
YHHN_ECOLIP0ADI9
yhhN
b3468 JW3433 Uncharacterized membrane protein yhhNIntegral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.165TMH07.64349-66Yn3-14c18/19o34-64i76-96o102-123i130-152o158-177i189-207oCytoplasmicMembrane10
RHTA_ECOLIP0AA67
rhtA

ybiF

ybiFb0813 JW0798 Inner membrane transporter rhtACell inner membrane Integral inner membrane (experimental).PMID: 12648727 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN320.17TMH06.46418-109Yn10-18c22/23o38-59i71-89o95-115i122-139o145-165i177-196o202-225i237-258o264-283iCytoplasmicMembrane10
YEDA_ECOLIP0AA70
yedA
b1959 JW1942 Uncharacterized inner membrane transporter yedAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN410.125TMH011.0617-109Yn6-16c21/22o37-56i68-86o98-117i124-143o149-169i176-199o211-233i245-262o268-290iCytoplasmicMembrane10
YHBE_ECOLIP0AA73
yhbE
b3184 JW3151 Uncharacterized inner membrane transporter yhbEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.149TMH00.144382-10100i7-26o38-56i71-91o103-120i132-151o157-177i189-205o217-236i248-269o281-299iCytoplasmicMembrane10
DGOT_ECOLIP0AA76
dgoT

yidT

yidTb3691 JW5859 D-galactonate transporterIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN430.138TMH04.18214-11120i15-35o55-75i82-98o104-122i142-163o169-188i242-263o283-304i316-332o338-362i369-392o404-424iCytoplasmicMembrane10
EXUT_ECOLIP0AA78
exuT
b3093 JW3064 Hexuronate transporterIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN180.107TMH00.456812-11120i47-66o86-109i116-136o142-162i174-199o205-224i277-299o305-325i345-362o368-389i401-424o430-452iCytoplasmicMembrane10
YHJT_ECOLIP0ADJ5
yhjT

yhjT

yhjTb3537 JW5663 Uncharacterized protein yhjTIntegral Inner Membrane BBinout/inIM (predicted)Membrane anchoredSRPSECnoyesN260.211CYT0-0.200913-110o6-25iUnknown268.44
YIAA_ECOLIP0ADJ8
yiaA
b3562 JW3534 Inner membrane protein yiaAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN220.118TMH07.26426-440i12-30o42-62i74-94o106-125iCytoplasmicMembrane1059.15
YIAW_ECOLIP0ADK4
yiaW
b3587 JW3559 Inner membrane protein yiaWIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.107TMH011.1792-220o6-25i46-66oCytoplasmicMembrane1020.57
GARP_ECOLIP0AA80
garP

yhaU

yhaUb3127 JW3096 Probable galactarate transporter (D-galactarate permease)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.195TMH03.99251-11120i12-32o52-73i85-103o109-130i151-173o179-199i251-270o290-314i326-345o351-372i379-406o412-434iCytoplasmicMembrane10
CODB_ECOLIP0AA82
codB
b0336 JW0327 Cytosine permeaseIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCnoyesN380.154TMH012.7134-12120i20-40o52-74i95-118o130-147i152-173o193-212i224-253o259-278i299-318o324-345i357-379o385-402iCytoplasmicMembrane10
DSBE_ECOLIP0AA86
dsbE

ccmG yejQ

ccmG yejQb2195 JW2183 Thiol:disulfide interchange protein dsbE (Cytochrome c biogenesis protein CcmG)Peripheral inner membrane protein facing the periplasm (experimental). Periplasmic with N-terminal membrane anchor. Periplasmic with N-terminal membrane anchor The CcmG protein was shown to be membrane bound, facing the periplasm with its C-terminal, hydrophilic domain. PMID: 9537397 PMID: 16364305 Disulfide bridge (80 83) PMID: 9537397 PMID: 16364305 Integral Inner Membrane BBoutin/outN/ACell inner membrane | Single-pass membrane protein | Periplasmic sidePeriplasmic with N-terminal membrane anchor (Experimental)SRPSECyesyesN290.264SpI278.59712-10Yn6-21c30/31oCytoplasmicMembrane1069.04
YPDA_ECOLIP0AA93
ypdA
b2380 JW5388 Inner membrane protein ypdAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN160.103TMH01.16348-660o6-25i45-64o76-99i106-128o140-161i173-191oCytoplasmicMembrane10
YICN_ECOLIP0ADL3
yicN
b3663 JW5637 Uncharacterized protein yicNEcholocation says Membrane anchored, one or two TMH predicted, if signal peptide is also predicted these TMH(s) are not removed as it is probably not cleaved.Integral Inner Membrane B-N/AMembrane anchoredSRPSECyesyesN270.132CYT0-0.200913-10Yn6-17c21/22oUnknown223.5
YIDG_ECOLIP0ADL6
yidG
b3675 JW3651 Inner membrane protein yidGIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN470.125TMH05.45771-330i21-39o45-65i91-116oCytoplasmicMembrane1021.31
YIDH_ECOLIP0ADM0
yidH
b3676 JW3652 Inner membrane protein yidHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.135TMH01.23486-330i21-39o54-72i93-114oCytoplasmicMembrane1020.4
YGAM_ECOLIP0ADQ7
ygaM
b2672 JW2647 Uncharacterized protein ygaMInner membrane, ribosomal binding YgaM is paralogous to YqjD and binds to ribsomes in a similar manner to YqjD. PMID: 22661687PMID: 22661687Integral Inner Membrane BBinin/outIM (predicted), Detected in IM FractionMembrane anchoredSRPSECnoyesN400.127CYT0-0.200913-110i87-106oUnknown250.39
YAGU_ECOLIP0AAA1
yagU
b0287 JW0281 Inner membrane protein yagUCell inner membrane Integral inner membrane (experimental).PMID: 16079137 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN300.316SpI293.31288-340i14-35o98-120i132-150o162-182iCytoplasmicMembrane1044.15
WZXE_ECOLIP0AAA7
wzxE

wzx yifJ

wzx yifJb3792 JW3766 Protein wzxEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.139TMH05.34268-1211Yn6-16c21/22o45-67i79-105o117-138i145-164o176-195i216-237o257-278i299-322o334-355i362-382o394-412iCytoplasmicMembrane10
YBHL_ECOLIP0AAC4
ybhL
b0786 JW0769 Inner membrane protein ybhLIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.151TMH05.60898-770i20-42o57-77i89-107o113-131i143-161o167-186i207-230oCytoplasmicMembrane10
YCCA_ECOLIP0AAC6
yccA
b0970 JW0953 Modulator of FtsH protease YccAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.268TMH07.78202-770i20-41o47-67i74-94o106-126i133-154o160-184i196-216oCytoplasmicMembrane10
MTR_ECOLIP0AAD2
mtr
b3161 JW3130 Tryptophan-specific transport protein (Tryptophan permease)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN470.192TMH019.2156-11110i12-34o40-65i86-107o127-145i152-170o190-207i228-246o284-309i321-340o346-367i388-410oCytoplasmicMembrane10
YGDD_ECOLIP0ADR2
ygdD
b2807 JW2778 UPF0382 inner membrane protein ygdDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.249TMH014.4685-43Yn7-20c24/25o40-61i68-91o97-121iCytoplasmicMembrane10
YQAE_ECOLIP0AE42
yqaE
b2666 JW2641 UPF0057 membrane protein yqaEIntegral Inner Membrane BBinoutout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN270.14TMH06.73627-210o23-48iCytoplasmicMembrane10
YJIG_ECOLIP0AEH8
yjiG
b4329 JW4292 Inner membrane protein yjiGIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN360.157TMH02.83449-340i21-39o59-77i89-110o130-152iCytoplasmicMembrane102.44
YIIR_ECOLIP0AF34
yiiR
b3921 JW3892 Uncharacterized protein yiiRIntegral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN380.144TMH05.06913-440i20-38o44-63i75-93o99-121iCytoplasmicMembrane1049.81
TYRP_ECOLIP0AAD4
tyrP
b1907 JW1895 Tyrosine-specific transport protein (Tyrosine permease)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN290.164TMH011.6392-1110Yn6-17c29/30o39-58i78-100o120-141i148-169o181-204i216-235o273-298i310-330o336-355i376-399oCytoplasmicMembrane10
SDAC_ECOLIP0AAD6
sdaC

dcrA

dcrAb2796 JW2767 Serine transporterIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN360.132TMH010.9503-11110i24-43o49-67i100-120o140-157i164-187o207-229i250-273o300-324i345-364o370-394i406-428oCytoplasmicMembrane10
TDCC_ECOLIP0AAD8
tdcC
b3116 JW3087 Threonine/serine transporter tdcC (H(+)/threonine-serine symporter)Integral inner membrane (experimental). Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 15919996 PMID: 25403562 PMID: 25403562Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECYfgMyesyesN350.131TMH09.58087-11110i23-42o48-66i97-116o136-155i167-186o206-234i255-278o317-337i358-379o391-409i421-440oCytoplasmicMembrane10
CYCA_ECOLIP0AAE0
cycA

dagA ytfD

dagA ytfDb4208 JW4166 D-serine/D-alanine/glycine transporterIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN530.108TMH03.35425-12120i28-45o51-71i108-130o136-154i166-187o207-231i252-274o286-311i347-365o371-397i417-435o441-460iCytoplasmicMembrane10
YIJD_ECOLIP0AF40
yijD
b3964 JW3936 Inner membrane protein yijDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.345TMH08.09717-43Yn10-21c26/27o36-51i63-83o89-108iCytoplasmicMembrane1021.82
YJCH_ECOLIP0AF54
yjcH
b4068 JW4029 Inner membrane protein yjcHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN480.119TMH04.65174-220i25-51o63-84iCytoplasmicMembrane1054.4
YJET_ECOLIP0AF73
yjeT
b4176 JW4134 Uncharacterized protein yjeTIntegral Inner Membrane BBinoutin/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN270.108TMH04.78812-21Yn3-13c17/18o41-60iCytoplasmicMembrane9.8219.85
YJFL_ECOLIP0AF80
yjfL
b4184 JW4142 UPF0719 inner membrane protein yjfLIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN220.123TMH08.65955-440o6-28i49-69o75-97i109-128oCytoplasmicMembrane1019.01
PROY_ECOLIP0AAE2
proY

yajM

yajMb0402 JW5055 Proline-specific permease proYIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN480.136TMH06.32309-12120i16-34o40-59i95-118o124-142i154-176o196-218i239-258o278-298i330-350o356-377i398-421o427-445iCytoplasmicMembrane10
ARCD_ECOLIP0AAE5
ydgI
b1605 JW1597 Putative arginine/ornithine antiporterNucleoid (experimental). Integral inner membrane (experimental).PMID: 23138451 PMID: 15919996Nucleoid, Integral Inner Membrane N, Bout/outIM (predicted)Cell inner membrane | Multi-pass membrane protein.Integral Membrane Protein (Experimental)SRPSECyesyesN220.206TMH08.33129-1312Yn5-16c25/26o41-61i82-107o127-145i157-178o204-222i234-257o283-311i332-352o358-378i385-402o408-426i441-459oCytoplasmicMembrane10
CADB_ECOLIP0AAE8
cadB
b4132 JW4093 Probable cadaverine/lysine antiporterIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN180.152TMH09.00829-12120i7-28o40-58i94-115o121-139i146-169o189-208i220-238o258-283i323-344o350-371i383-401o407-424iCytoplasmicMembrane10
POTE_ECOLIP0AAF1
potE
b0692 JW0679 Putrescine-ornithine antiporter (Putrescine transport protein)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN500.144TMH05.94665-12120i12-30o42-60i90-110o122-140i152-172o184-204i225-249o276-300i321-345o351-374i386-404o410-428iCytoplasmicMembrane10
PSPB_ECOLIP0AFM9
pspB
b1305 JW1298 Uncharacterized protein yqeK Defects in yidC and sec secretion induce psp operon. PMID: 14594846PMID: 14594846Integral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECProphage Transposase (by homology to BL21)noyesN300.112CYT0-0.200913-110o6-24iCytoplasmicMembrane1062.96
PSPC_ECOLIP0AFN2
pspC
b1306 JW1299 Phage shock protein C Defects in yidC and sec secretion induce psp operon. PMID: 14594846PMID: 14594846Integral Inner Membrane BBinoutout/inIM (predicted)Cell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECProphage TransposaseyesnoN250.142CYT0-0.200913-110o39-64iCytoplasmicMembrane9.8229.03
YADS_ECOLIP0AFP0
yadS
b0157 JW0153 UPF0126 inner membrane protein yadSIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN230.24TMH02.68818-770o6-23i30-50o62-79i91-110o116-137i149-168o174-190iCytoplasmicMembrane10
YHID_ECOLIP0AFV2
yhiD

yhhE

yhhEb3508 JW5670 Uncharacterized protein yhiDIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN550.254CYT0-0.200913-550o6-22i34-54o69-87i92-112o118-138iCytoplasmicMembrane1028.82
MDLB_ECOLIP0AAG5
mdlB

mdl

mdlb0449 JW5061 Multidrug resistance-like ATP-binding protein mdlB (EC 3.6.3.44)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN380.136SpI374.21577-44Yn25-32c37/38o61-81i138-161o167-185i250-273oCytoplasmicMembrane106.66
FTSH_ECOLIP0AAI3
ftsH

hflB mrsC std tolZ

hflB mrsC std tolZb3178 JW3145 ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) (Cell division protease FtsH)Cell inner membrane Cell inner membrane Inner membrane (experimental). Integral inner membrane (experimental). Integral Membrane Protein Integral Membrane Protein Integral Membrane Protein Integral Membrane ProteinTrigger factor-sensitive aggregation. PMID: 8444797 PMID: 1925026 PMID: 8106505 PMID: 8106505 PMID: 7781608PMID: 7500942 PMID: 19737520 PMID: 8444797 PMID: 8947034 PMID: 15919657 PMID: 15919996 PMID: 1925026 PMID: 8106505 PMID: 8106505 PMID: 7781608Integral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRP,TFSECnoyesN240.152SpI212.2847-21Yn5-16c21/22o98-119iCytoplasmicMembrane1041.14
FDNH_ECOLIP0AAJ3
fdnH
b1475 JW1471 Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit (Anaerobic formate dehydrogenase iron-sulfur subunit) (Formate dehydrogenase-N subunit beta) (FDH-N subunit beta)Membrane anchored Alpha-helcal transmembrane protein (experimental). Transmembrane helices: 1.Part of the formate dehydrogenase N (FDH-N) of Escherichia coli which is a membrane-bound enzyme comprising FdnG, FdnH, and FdnI subunits. PMID: 11884747 PMID: 16858726PMID: 15342602 PMID: 16858726 PMID: 11266632 PMID: 11884747Integral Inner Membrane BBinin/outIM (predicted)Cell membrane | Single-pass membrane proteinMembrane anchored (Experimental)SRPSECyesyesN240.116CYT0-0.200913-110i260-279oCytoplasmicMembrane1080.89
YMIA_ECOLIP0CB62
ymiA
b4522 JW1267.1 Uncharacterized protein ymiASmall membrane protein detected experimentallyPMID: 19121005Integral Inner Membrane BBinoutin/outN/AMembrane | Single-pass membrane protein-SECnoyesN350.102TMH01.19842-110i20-41oCytoplasmicMembrane9.82
YIAB_ECOLIP11286
yiaB
b3563 JW5654 Inner membrane protein yiaBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN500.132TMH07.23112-440i7-26o32-50i62-87o93-110iCytoplasmicMembrane1038.39
FLIO_ECOLIP22586
fliO

flaP flbD

flaP flbDb1947 JW5316 Flagellar protein fliOIntegral Inner Membrane BBinoutout/inIM (predicted)Cell membrane | Single-pass membrane proteinBacterial flagellum basal bodyMembrane anchoredflagellumSRPSECnoyesN270.161TMH00.0866025-110o18-39iCytoplasmicMembrane9.9714.69
YCCB_ECOLIP24244
yccB
b4592 JW0961.1 b0979.1Uncharacterized protein yccBOuter membrane.Experimentally verified orientation: N(out)-C(in).PMID: 19121005 PMID: 21778229Integral Inner Membrane BBinoutout/inN/AMembrane | Single-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN210.107TMH02.07613-110o6-24iCytoplasmicMembrane9.82
CYBH_ECOLIP0AAM1
hyaC
b0974 JW0956 Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunitIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.112TMH010.0819-460o20-40i61-80o100-116i128-151o157-174i186-203oCytoplasmicMembrane10
ADRA_ECOLIP0AAP1
adrA

yaiC

yaiCb0385 JW0376 Probable diguanylate cyclase AdrA (DGC) (EC 2.7.7.65)Integral Membrane Protein Integral Membrane Protein Integral Membrane ProteinPMID: 10760159 PMID: 12673057 PMID: 16585767Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein(experimental)SRPSECyesyesN200.116CYT0-0.200913-550i43-61o67-85i106-130o142-167i174-193oCytoplasmicMembrane1022.58
YBBJ_ECOLIP0AAS3
ybbJ
b0488 JW5065 Inner membrane protein ybbJIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN230.17TMH018.8226-330o6-23i30-49o55-72iCytoplasmicMembrane1012.04
YBDG_ECOLIP0AAT4
mscM

ybdG

ybdGb0577 JW0566 Uncharacterized protein ybdGMembrane protein. Integral inner membrane (experimental).Mechanosensitive channel of miniconductance activity (MscM).PMID: 20616037 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN390.102CYT0-0.200913-550o23-48i68-87o107-127i139-160o166-183iCytoplasmicMembrane1011.27
ELYC_ECOLIP0AB01
ycbC
b0920 JW0903 Uncharacterized protein ycbCShown to play a critical role in the metabolism of the essential lipid carrier used for the biogenesis of cell wall and other bacterial surface polysaccharides.PMCID: PMC3879167Integral Inner Membrane BBpolyout/outIM (predicted)Integral Membrane ProteinSRPSECyesyesN600.155TMH09.49418-220o12-32i41-59oCytoplasmicMembrane9.8224.71
YIGF_ECOLIP27842
yigF
b3817 JW3790 Uncharacterized protein yigFIntegral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECnoyesN400.108CYT0-0.200913-220i52-72o78-107iCytoplasmicMembrane9.8225.78
YIGG_ECOLIP27843
yigG
b3818 JW5590 Uncharacterized protein yobICell inner membrane Integral inner membrane (experimental).PMID: 11867724 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN420.121TMH05.14332-440i18-35o41-57i69-91o103-121iCytoplasmicMembrane10
YHHH_ECOLIP28911
yhhH
b3483 JW3449 Uncharacterized protein yhhH (ORF-B2)Integral Inner Membrane BBoutin/outIM (predicted)Membrane anchoredSRPSECnoyesN320.366CYT0-0.200913-110i12-30oUnknown252
YIDI_ECOLIP31446
yidI
b3677 JW3653 Inner membrane protein yidIIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN360.149TMH00.964289-330i12-30o78-98i110-143oCytoplasmicMembrane1027.57
LAPB_ECOLIP0AB58
yciM
b1280 JW1272 Uncharacterized protein yciMInner membrane. Potential TAT secreted protein. Required to maintain cell envelope integrity. Heat shock protein involved in the assembly of LPS. In pull-down experiments, LapA and LapB co-purified with LPS, Lpt proteins, FtsH (protease), DnaK, and DnaJ (chaperones). PMID: 25403562PMID: 24187084 PMID: 25403562Integral Inner Membrane B-Soluble IM FractionPeriplasmicSECyesyesN250.264CYT0-0.200913-00Yn4-11c16/17oCytoplasmic8.969.37
PNTB_ECOLIP0AB67
pntB
b1602 JW1594 NAD(P) transhydrogenase subunit beta (EC 1.6.1.2) (Nicotinamide nucleotide transhydrogenase subunit beta) (Pyridine nucleotide transhydrogenase subunit beta)Integral inner membrane (experimental). Integral inner membrane (experimental).PMID: 14660605 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.125TMH09.6368-990o6-24i36-51o57-74i86-105o125-143i163-180o186-207i214-234o240-260iCytoplasmicMembrane10
ARSB_ECOLIP0AB93
arsB

arsF

arsFb3502 JW3469 Arsenical pump membrane protein (Arsenic efflux pump protein)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN440.23TMH08.42262-1110Yn2-17c35/36o51-70i91-109o115-132i139-163o175-198i222-240o246-263i275-296o316-334i401-423oCytoplasmicMembrane10
ATP6_ECOLIP0AB98
atpB

papD uncB

papD uncBb3738 JW3716 ATP synthase subunit a (ATP synthase F0 sector subunit a) (F-ATPase subunit 6)Integral inner membrane (experimental). Integral Membrane ProteinExhibites aberrant localization by microscopy in the absence of YidC. PMID: 10806384PMID: 22108384 PMID: 15263011 PMID: 15919996 PMID: 10806384Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPYidCyesyesN670.123CYT0-0.200913-550o36-60i100-118o147-166i211-233o239-264iCytoplasmicMembrane107.26
CBRB_ECOLIP31468
cbrB

yieI

yieIb3716 JW3694 Inner membrane protein CbrB (CreB-regulated gene B protein)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN340.114TMH014.4652-440i12-32o38-69i81-100o120-138iCytoplasmicMembrane1025.64
YDCD_ECOLIP31991
ydcD
b1457 JW1452 Uncharacterized protein ydcD (ORF-E2)Integral Inner Membrane BBoutin/outIM (predicted)Membrane anchoredSRPSECnoyesN320.142CYT0-0.200913-110i7-25oUnknown29.14
YIBI_ECOLIP32108
yibI
b3598 JW3572 Uncharacterized protein yibIIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN270.12TMH012.0249-220o6-25i46-66oCytoplasmicMembrane1033.12
PSPG_ECOLIP32696
pspG

yjbO

yjbOb4050 JW5716 Phage shock protein GCell inner membranePMID: 19555453Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECProphage TransposasenonoN320.133TMH016.1628-220i7-37o43-64iCytoplasmicMembrane9.82
ATPF_ECOLIP0ABA0
atpF

papF uncF

papF uncFb3736 JW3714 ATP synthase subunit b (ATP synthase F(0) sector subunit b) (ATPase subunit I) (F-type ATPase subunit b) (F-ATPase subunit b) Membrane anchoredPMID: 15263011 PMID: 21541338 PMID: 6278247Integral Inner Membrane BBinout/inSoluble IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchored (Experimental)SRPSECnoyesN320.35CYT0-0.200913-110o6-26iCytoplasmicMembrane1019.55
ATMA_ECOLIP0ABB8
mgtA

corB mgt

corB mgtb4242 JW4201 Magnesium-transporting ATPase, P-type 1 (EC 3.6.3.2) (Mg(2+) transport ATPase, P-type 1)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN470.122CYT0-0.200913-780i89-112o118-137i291-309o315-342i768-791o803-821i833-857o869-891iCytoplasmicMembrane1050.58
HFLC_ECOLIP0ABC3
hflC

hflA

hflAb4175 JW4133 Uncharacterized protein yqeLCell inner membrane Membrane anchored N-terminally located transmembrane segment. PMID: 9792691 Translocation of the C-terminal domains of HflKC was retarded markedly when sodium azide was added to inhibit SecA ATPase and blocked almost completely in secY- or secD-defective mutant cells. PMID: 9792691PMID: 8947034 PMID: 16834335 PMID: 9792691 PMID: 9792691Integral Inner Membrane BBinout/inSoluble IM FractionCell inner membrane | Single-pass type II membrane proteinMembrane anchored (Experimental)SRPSECProphage Transposase (by homology to BL21)yesyesN250.135CYT0-0.200913-110o6-23iCytoplasmic8.9646.95
HFLK_ECOLIP0ABC7
hflK

hflA

hflAb4174 JW4132 Modulator of FtsH protease HflKCell inner membrane Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 N-terminally located transmembrane segment. PMID: 9792691 Translocation of the C-terminal domains of HflKC was retarded markedly when sodium azide was added to inhibit SecA ATPase and blocked almost completely in secY- or secD-defective mutant cells. PMID: 9792691PMID: 8947034 PMID: 21541338 PMID: 9792691 PMID: 9792691Integral Inner Membrane BBoutin/outIM (predicted)Cell inner membrane | Single-pass type II membrane proteinMembrane anchoredSRPSECProphage TransposaseyesnoN30.101CYT0-0.200913-110i80-100oUnknown5.4820.03
YJCB_ECOLIP32700
yjcB
b4060 JW5718 Uncharacterized protein yjcBPMID: 19555453Integral Inner Membrane BBpolyout/outIM (predicted)Integral Membrane ProteinSRPSECyesyesN650.12TMH09.92398-220o12-29i36-56oCytoplasmicMembrane9.8245.88
NRFF_ECOLIP32711
nrfF

yjcM

yjcMb4075 JW4036 Formate-dependent nitrite reductase complex subunit nrfFIntegral Inner Membrane BBoutout/inIM (predicted)PeriplasmMembrane anchoredSRPSECnoyesY190.845SpI1816.61-11Yn4-14c18/19o103-121iCytoplasmicMembrane1020.08
BETT_ECOLIP0ABC9
betT
b0314 JW0306 High-affinity choline transport proteinCell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN370.108TMH011.6116-12120i16-35o55-79i91-115o143-166i194-215o235-253i265-290o319-338i350-368o403-422i448-467o479-497iCytoplasmicMembrane10
YEAV_ECOLIP0ABD1
yeaV
b1801 JW5293 Uncharacterized protein ynbGIntegral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN190.119TMH02.33182-1011Yn2-13c18/19o34-59i80-104o136-158i170-191o203-221i228-246o258-277i289-308o348-371i392-412o418-438iCytoplasmicMembrane10
C561_ECOLIP0ABE5
cybB
b1418 JW5224 Cytochrome b561 (Cytochrome b-561)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCnoyesN230.142TMH07.83021-440i12-33o39-62i82-106o143-162iCytoplasmicMembrane1031.95
PGSA_ECOLIP0ABF8
pgsA
b1912 JW1897 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase (EC 2.7.8.5) (Phosphatidylglycerophosphate synthase) (PGP synthase)Integral inner membrane (experimental). Integral inner membrane (experimental).Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 12558186 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN350.17TMH012.5336-460i7-27o33-52i64-83o89-108i120-142o148-169iCytoplasmicMembrane107.29
CDSA_ECOLIP0ABG1
cdsA

cds

cdsb0175 JW5810 Phosphatidate cytidylyltransferase (EC 2.7.7.41) (CDP-DAG synthase) (CDP-DG synthase) (CDP-diacylglycerol synthase) (CDS) (CDP-diglyceride pyrophosphorylase) (CDP-diglyceride synthase) (CTP:phosphatidate cytidylyltransferase)Integral inner membrane (experimental).Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. PMID: 15919996PMID: 9008159 PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRP (exp)SECyesyesN300.287TMH018.3357-88Yn6-13c18/19o28-44i56-73o93-113i120-141o153-171i192-210o216-234i264-282oCytoplasmicMembrane10
MOKC_ECOLIP33236
mokC

gefL

gefLb0018 JW5879 Regulatory protein mokCIntegral Inner Membrane BBoutin/outN/AMembrane | Single-pass membrane proteinPeriplasmicSRPSECnoyesN410.287SpI401.37208-110i25-44oPeriplasmic9.97
YBBD_ECOLIP33669
ybbD
b0501 JW0489 Putative uncharacterized protein ybbDIntegral Inner Membrane BBinout/inIM (predicted)Membrane anchoredSRPSECpseudogene (Uniprot) nonoN350.114TMH09.05171-110o12-32iCytoplasmicMembrane9.8246.29
PPDD_ECOLIP36647
ppdD
b0108 JW0104 Prepilin peptidase-dependent protein DIntegral Inner Membrane BBoutin/outIM (predicted)FimbriumMembrane anchoredSRPSECnoyesN530.143TMH04.07217-110i12-30oExtracellular9.719.63
FTSW_ECOLIP0ABG4
ftsW
b0089 JW0087 Cell division protein ftsWInner membrane. Cell inner membrane Cell inner membrane Cell inner membrane Integral inner membrane (experimental).Interacts directly with FtsN. The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex.PMID: 20847002 PMID: 20497333 PMID: 9603865 PMID: 12423747 PMID: 11807049 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN670.137TMH010.7628-109Yn15-26c32/33o48-66i87-104o110-129i175-192o198-215i222-239o307-328i340-364o376-395iCytoplasmicMembrane10
RODA_ECOLIP0ABG7
mrdB

rodA

rodAb0634 JW0629 Rod shape-determining protein rodAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.198TMH06.46483-990o20-38i50-68o74-95i136-154o160-176i183-202o263-289i310-332o338-359iCytoplasmicMembrane10
CORA_ECOLIP0ABI4
corA
b3816 JW3789 Magnesium transport protein CorAIntegral inner membrane (experimental). Exhibites aberrant localization by microscopy in the absence of YidC. Single particle electron microscopy analysis and two-dimensional crystals of PPD (large soluble periplasmic domain) of CorA indicated that E. coli CorA PPD is a pyramid-like homotetramer with a central cavity.PMID: 22108384 PMID: 15919996 PMID: 16835234Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN270.101CYT0-0.200913-220i255-278o290-310iCytoplasmicMembrane1065.69
CYOB_ECOLIP0ABI8
cyoB
b0431 JW0421 Ubiquinol oxidase subunit 1 (EC 1.10.3.-) (Cytochrome o subunit 1) (Cytochrome o ubiquinol oxidase subunit 1) (Oxidase BO(3) subunit 1) (Ubiquinol oxidase chain A) (Ubiquinol oxidase polypeptide I)Integral inner membrane (experimental). Cell inner membrane Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 11017202 PMID: 11266632 PMID: 22108384 PMID: 6365921 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN310.108TMH010.2812-14140o16-38i59-79o103-126i146-170o190-213i233-255o275-298i310-334o346-368i380-403o415-436i457-479o491-518i593-626oCytoplasmicMembrane10
FXSA_ECOLIP37147
fxsA

yjeG

yjeGb4140 JW4100 UPF0716 protein fxsA (Suppressor of F exclusion of phage T7)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN640.114TMH05.51241-330o6-24i29-47o78-101iCytoplasmicMembrane1025.95
HOKA_ECOLIP37305
hokA

yiaZ

yiaZb4455 JW3526 Protein hokAPotentially toxic protein.PMID: 19121005Integral Inner Membrane BBoutin/outIM (predicted)Membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN250.11CYT0-0.200913-110i7-24oPeriplasmic9.24110.3
YHHL_ECOLIP37614
yhhL
b3466 JW5683 Uncharacterized protein yhhLIntegral Inner Membrane BBinoutout/outIM (predicted)Integral Membrane ProteinSRPSECnoyesN250.114TMH01.98334-21Yn8-19c24/25o34-51iCytoplasmicMembrane9.8247.43
CYOA_ECOLIP0ABJ1
cyoA
b0432 JW0422 Ubiquinol oxidase subunit 2 (EC 1.10.3.-) (Cytochrome o subunit 2) (Cytochrome o ubiquinol oxidase subunit 2) (Ubiquinol oxidase chain B) (Oxidase BO(3) subunit 2) (Ubiquinol oxidase polypeptide II)Lipoprotein (experimental). Alpha-helcal transmembrane protein (experimental). Cell inner membrane Cell inner membrane Integral inner membrane (experimental). Integral inner membrane (experimental). Proven signal peptidase II substrate PMID: 15174130. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 The SRP interacts with the first TM of CyoA (rather than with its signal sequence) to mediate targeting of CyoA to the Sec/YidC insertion site in the inner membrane. PMID: 16481320 Efficient insertion of in vitro synthesized pre-CyoA into proteoliposomes requires YidC, SecYEG, and SecA and occurs independently of the proton motive force. PMID: 16513637PMID: 15174130 PMID: 11266632 PMID: 11017202 PMID: 6365921 PMID: 16079137 PMID: 15919657 PMID: 15919996 PMID: 21541338 PMID: 16481320 PMID: 16513637Integral Inner Membrane, Inner Membrane LipoproteinB, EBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.189TMH011.3494-32Yn10-22c27/28o43-67i88-108oCytoplasmicMembrane1019.49
CYOC_ECOLIP0ABJ3
cyoC
b0430 JW0420 Cytochrome o ubiquinol oxidase subunit 3 (EC 1.10.3.-) (Cytochrome o ubiquinol oxidase subunit III) (Ubiquinol oxidase chain C)Integral inner membrane (experimental). Integral inner membrane (experimental).PMID: 11017202 PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN140.175TMH03.44396-550i29-50o70-91i98-118o138-165i177-201oCytoplasmicMembrane10
CYDA_ECOLIP0ABJ9
cydA

cyd-1

cyd-1b0733 JW0722 Cytochrome d ubiquinol oxidase subunit 1 (EC 1.10.3.-) (Cytochrome bd-I oxidase subunit I) (Cytochrome d ubiquinol oxidase subunit I)Cell inner membrane Cell inner membrane Inner membrane (experimental). Integral inner membrane (experimental).Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 15013751 PMID: 16079137 PMID: 15919657 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN370.106TMH09.54728-990o20-42i54-71o91-116i128-151o184-208i220-238o388-409i421-444o471-494iCytoplasmicMembrane10
YHHM_ECOLIP37615
yhhM
b3467 JW3432 Uncharacterized protein yhhMSingle transmembrane helice predicted which would be removed upon signal peptide cleavage IM-cter inside.Integral Inner Membrane BBinout/inN/AMembrane anchoredSRPSECyesyesN320.135CYT0-0.200913-110o6-24iUnknown275.11
YHHQ_ECOLIP37619
yhhQ
b3471 JW3436 Inner membrane protein yhhQIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.133TMH011.3075-660i12-31o43-64i71-92o104-127i139-165o185-206iCytoplasmicMembrane10
YIAM_ECOLIP37674
yiaM
b3577 JW3549 2,3-diketo-L-gulonate TRAP transporter small permease protein yiaMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN230.132TMH06.97669-440i7-28o40-59i80-101o113-137iCytoplasmicMembrane1013.66
CYDB_ECOLIP0ABK2
cydB

cyd-2

cyd-2b0734 JW0723 Cytochrome d ubiquinol oxidase subunit 2 (EC 1.10.3.-) (Cytochrome bd-I oxidase subunit II) (Cytochrome d ubiquinol oxidase subunit II)Cell inner membrane Cell inner membrane Integral inner membrane (experimental).Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 15013751 PMID: 16079137 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN290.118TMH010.5085-880i9-28o77-99i119-141o161-181i202-226o264-283i290-315o335-360iCytoplasmicMembrane10
NAPC_ECOLIP0ABL5
napC

yejX

yejXb2202 JW2190 Cytochrome c-type protein napCPeriplasm Inner membrane Periplasmic with N-terminal membrane anchor Nitrate reductase, napFDAGHBC, is located in the periplasm. E. coli also expresses two membrane-bound proton-translocating nitrate reductases, encoded by the narGHJI and narZYWV operons. PMID: 11844760 Electrons are fed into the NapAB dimer from a membrane-anchored tetra-heme cytochrome c,encoded by the napC gene. PMID: 8830238 PMID: 12186631PMID: 11844760 PMID: 8830238 PMID: 12186631Integral Inner Membrane BBoutin/outIM (predicted)Cell inner membrane | Single-pass membrane proteinPeriplasmic with N-terminal membrane anchor (Experimental)SRPSECyesyesN520.116TMH06.01984-110i21-44oCytoplasmicMembrane1014.18
CCMB_ECOLIP0ABL8
ccmB

yejV

yejVb2200 JW2188 Heme exporter protein B (Cytochrome c-type biogenesis protein CcmB)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN200.11TMH09.26722-660i21-39o45-70i82-103o123-145i157-180o192-215iCytoplasmicMembrane104.38
CCMC_ECOLIP0ABM1
ccmC

yejT yejU

yejT yejUb2199 JW2187 Heme exporter protein C (Cytochrome c-type biogenesis protein CcmC)Integral inner membrane (experimental). Exhibites aberrant localization by microscopy in the absence of YidC. CcmC, CcmE, and heme interact directly with each other, establishing a periplasmic heme delivery pathway for cytochrome c maturation. PMID: 11384983PMID: 22108384 PMID: 15919996 PMID: 11384983Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCnoyesN290.15TMH014.9856-660i21-43o63-84i91-113o133-149i161-182o202-221iCytoplasmicMembrane10
CCMH_ECOLIP0ABM9
ccmH

yejP

yejPb2194 JW2182 Cytochrome c-type biogenesis protein CcmHIntegral inner membrane (experimental). Integral inner memrbane. Might be is co-translationally translocated through Sec translocon. CcmH is a periplasm-resident oxidoreductase anchored to the inner membrane by two transmembrane segments. Both N- and C-terminal domains are located and function in the periplasmic compartment. PMID: 22789558 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024PMID: 15838024 PMID: 15919996 PMID: 22789558 PMID: 15838024Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesY190.795SpI188.87226-32Yn3-13c18/19o102-120i147-166oCytoplasmicMembrane1041.31
SIEB_ECOLIP38392
sieB
b1353 JW5209 Superinfection exclusion protein BCell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Membrane | Peripheral membrane proteinIntegral Membrane ProteinSRPSECProphage Integrase (EcoGene)nonoN420.105TMH03.43476-220i20-38o50-70iCytoplasmicMembrane1013.63
YJEO_ECOLIP39284
yjeO
b4158 JW4119 Toxin yoeB (EC 3.1.-.-)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.227TMH07.24951-32Yn6-17c25/26o55-72i79-98oCytoplasmicMembrane1056.51
KDGL_ECOLIP0ABN1
dgkA
b4042 JW4002 Diacylglycerol kinase (DAGK) (EC 2.7.1.107) (Diglyceride kinase) (DGK)Integral inner membrane (experimental). Integral Membrane Protein Integral Membrane ProteinPMID: 15919996 PMID: 2984194 PMID: 8071224Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN540.112CYT0-0.200913-230i30-51o57-80i100-121oCytoplasmicMembrane1031.25
DCUA_ECOLIP0ABN5
dcuA

genA

genAb4138 JW5735 Anaerobic C4-dicarboxylate transporter dcuAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN280.186TMH07.74612-11110o6-38i45-66o86-109i130-152o164-190i225-243o255-277i289-306o326-345i357-381o410-431iCytoplasmicMembrane10
DCUB_ECOLIP0ABN9
dcuB

genF

genFb4123 JW4084 Anaerobic C4-dicarboxylate transporter dcuBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN680.125TMH08.74519-1110Yn2-13c17/18o27-44i51-71o91-118i139-162o174-195i236-254o266-288i300-318o342-372i421-445oCytoplasmicMembrane10
DCUC_ECOLIP0ABP3
dcuC
b0621 JW0613/JW0616 Anaerobic C4-dicarboxylate transporter dcuCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN560.117TMH00.537839-12120i5-22o28-46i79-98o118-144i156-175o195-218i238-260o266-288i309-333o339-363i406-424o436-458iCytoplasmicMembrane103.79
DEDA_ECOLIP0ABP6
dedA
b2317 JW2314 Protein dedA (Protein DSG-1)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC. Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF.PMID: 22108384 PMID: 15919996 PMID: 23086209Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN200.121CYT0-0.200913-440i27-49o69-92i156-178o190-208iCytoplasmicMembrane10
YTFB_ECOLIP39310
ytfB
b4206 JW5745 Uncharacterized protein ytfBIntegral Inner Membrane BBinoutin/outIM (predicted)Membrane | Single-pass membrane proteinCytoplasmicSRPSECnoyesN570.108CYT0-0.200913-010i30-48oExtracellular9.7157.94
YJHE_ECOLIP39355
yjhE
b4282 Putative uncharacterized protein yjhEIntegral Inner Membrane B-IM (predicted)Integral Membrane ProteinSRPSECpseudogene (Uniprot) nonoN380.334CYT0-0.200913-220i22-49o55-76iCytoplasmicMembrane1015.12
YJIH_ECOLIP39379
yjiH
b4330 JW5783 Uncharacterized protein yjiHIntegral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN380.143TMH05.26808-440i21-39o86-104i116-135o176-201iCytoplasmicMembrane9.8216.56
YIJE_ECOLIP0ABT8
yijE
b3943 JW5557 Uncharacterized inner membrane transporter yiJEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN300.12TMH07.7108-10100i12-29o35-59i71-91o97-118i125-141o153-171i183-205o217-239i246-266o272-289iCytoplasmicMembrane10
EXBB_ECOLIP0ABU7
exbB
b3006 JW2974 Biopolymer transport protein exbBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.153CYT0-0.200913-330o21-43i132-157o177-198iCytoplasmicMembrane1014.97
TOLQ_ECOLIP0ABU9
tolQ

fii

fiib0737 JW0727 Protein tolQIntegral inner membrane (experimental). Integral Membrane Protein Integral Membrane ProteinSignal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. PMID: 8300535 PMID: 8331075PMID: 9008159 PMID: 15919996 PMID: 8300535 PMID: 8331075Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRP (exp)SECyesyesN340.244TMH02.05597-330o15-35i139-159o171-192iCytoplasmicMembrane109.25
FLIP_ECOLIP0AC05
fliP

flaR

flaRb1948 JW1932 Flagellar biosynthetic protein fliPPolytopic inner membrane. Cell inner membrane, Bacterial flagellum basal bodyA cleavable signal peptide is required for the full function of FliP protein.PMID: 15194505 PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinBacterial flagellum basal bodyIntegral Membrane ProteinflagellumSRPSECnoyesY220.692TMH013.015-54Yn4-15c21/22o45-74i86-105o185-211i223-244oCytoplasmicMembrane10
FOCA_ECOLIP0AC23
focA

ycaE

ycaEb0904 JW0887 Probable formate transporter 1 (Formate channel 1)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.124TMH01.35944-660i35-55o75-98i118-141o161-180i192-212o255-277iCytoplasmicMembrane10
YGJQ_ECOLIP42598
ygjQ
b3086 JW3057 Uncharacterized protein ygjQIntegral Inner Membrane BBoutin/outN/AMembrane | Single-pass membrane proteinPeriplasmicSRPSECnoyesN370.199SpI366.02153-10Yn21-31c36/37oCytoplasmicMembrane9.82
YGJV_ECOLIP42603
ygjV
b3090 JW3061 Inner membrane protein ygjVIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN560.156TMH04.26984-550o6-24i36-59o71-89i101-124o136-157iCytoplasmicMembrane10
YQJB_ECOLIP42615
mzrA

ecfM yqjB

ecfM yqjBb3096 JW3067 Uncharacterized protein yqjBCell inner membrane Cell inner membranePMID: 19432797 PMID: 20889743Integral Inner Membrane BBoutin/outN/AMembrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN300.154SpI294.521-10Yn11-22c27/28oUnknown2.514.58
YQJF_ECOLIP42619
yqjF
b3101 JW5850 Inner membrane protein yqjFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.118TMH08.80873-440i7-26o46-66i73-91o103-122iCytoplasmicMembrane10
NIRC_ECOLIP0AC26
nirC
b3367 JW3330 Probable nitrite transporterIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.428TMH04.72286-660i25-47o59-80i101-126o146-169i181-206o226-248iCytoplasmicMembrane10
FTSX_ECOLIP0AC30
ftsX

ftsS

ftsSb3462 JW3427 Cell division protein ftsXCell inner membrane Cell inner membrane Cell inner membrane Integral inner membrane (experimental).Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 3323846 PMID: 10048040 PMID: 14729705 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN390.105CYT0-0.200913-440o72-95i214-240o272-290i323-342oCytoplasmicMembrane1023.24
DHSD_ECOLIP0AC44
sdhD
b0722 JW0712 Succinate dehydrogenase hydrophobic membrane anchor subunit. Alpha-helcal transmembrane protein (experimental). Integral inner membrane (experimental).PArt of colisuccinate dehydrogenase (SQR) composed of two hydrophilic subunits, a flavoprotein (SdhA) and iron-sulfur protein (SdhB) subunit, and two hydrophobic membrane anchor subunits, SdhC and SdhD.PMID: 11266632 PMID: 12560550 PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN390.133TMH010.7371-330i17-39o59-80i92-113oCytoplasmicMembrane1044.37
KDTA_ECOLIP0AC75
waaA

kdtA

kdtAb3633 JW3608 3-deoxy-D-manno-octulosonic-acid transferase (EC 2.4.-.-) (KDO transferase)Potential membrane association. Monotopic membrane protein.Involved in lipopolysaccharide biosynthesis PMID: 2651435 PMID: 1577828. Embedded in the cytoplasmic face of the inner membrane, WaaA catalyzes the transfer of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) to the lipid A precursor of LPS (in Aquifex aeolicus) PMID: 22474366.PMID: 2651435 PMID: 1577828 PMID: 15866922 PMID: 22474366 PMID: 19275539Integral Inner Membrane BBinout/inIM (predicted)Cell inner membrane | Single-pass membrane proteinCytoplasmicSRPSECyesyesN640.121CYT0-0.200913-010o6-23iUnknown215.12
PTPC2_ECOLIP42905
agaW
b3134 Putative N-acetylgalactosamine permease IIC component 2 (EIIC-Aga') (PTS system N-acetylgalactosamine-specific EIIC component 2)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)noyesN700.132TMH06.59862-330o6-26i33-56o94-116iCytoplasmicMembrane109.53
YGAH_ECOLIP43667
ygaH
b2683 JW2658 Uncharacterized protein ygaHIntegral Inner Membrane BBpolyout/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN180.142CYT0-0.200913-33Yn5-15c20/21o36-57i69-85o91-109iCytoplasmicMembrane10
YHDT_ECOLIP45566
yhdT
b3257 JW3225 Uncharacterized protein yhdTIntegral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN300.15TMH015.9222-220i12-33o45-65iCytoplasmicMembrane9.8243.21
YBCI_ECOLIP45570
ybcI
b0527 JW0516 Inner membrane protein ybcIIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN410.121TMH04.35035-440i27-47o59-78i85-103o149-170iCytoplasmicMembrane104.77
WECA_ECOLIP0AC78
wecA

rfe

rfeb3784 JW3758 Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase (EC 2.7.8.n2) (UDP-GlcNAc:undecaprenyl-phosphate GlcNAc-1-phosphate transferase) (Undecaprenyl-phosphate GlcNAc-1-phosphate transferase)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN290.115CYT0-0.200913-11110o6-24i45-66o72-89i101-119o131-149i161-179o185-206i213-232o244-263i294-315o321-342iCytoplasmicMembrane10
GNTP_ECOLIP0AC94
gntP

yjiB

yjiBb4321 JW4284 High-affinity gluconate transporter (Gluconate permease 3) (Gnt-III system)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN430.178TMH07.17039-13120i7-23o29-49i61-79o99-132i139-157o177-201i222-249o261-280i301-320o340-373i380-402o422-446iCytoplasmicMembrane10
GNTU_ECOLIP0AC96
gntU
b4476 JW5686 Low-affinity gluconate transporter (Gluconate permease) (Gnt-I system)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECpseudogene (Ochman & Davalos, 2006)yesyesN310.139TMH010.5274-13120i5-22o28-47i59-80o100-128i140-163o175-197i226-250o262-282i303-320o340-373i385-408o428-445iCytoplasmicMembrane10
HEMY_ECOLIP0ACB7
hemY
b3802 JW3774 Protein hemYIntegral inner membrane (experimental).Trigger factor-sensitive aggregation.PMID: 19737520 PMID: 15919996Integral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP,TFSECyesyesN230.235TMH010.5296-21Yn4-17c26/27o42-62iCytoplasmicMembrane1019.06
HTRB_ECOLIP0ACV0
htrB

waaM

waaMb1054 JW1041 Lipid A biosynthesis lauroyl acyltransferase (EC 2.3.1.-) (Heat shock protein B)Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN200.104TMH01.65586-120i12-30o36-52iCytoplasmicMembrane1011.65
YRFB_ECOLIP45751
hofO

yrfB

yrfBb3393 JW3356 Uncharacterized protein yrfBIntegral Inner Membrane BBinout/inIM (predicted)Membrane anchoredSRPSECyesyesN400.213TMH06.9432-110o20-38iUnknown219.63
YBJC_ECOLIP46119
ybjC
b0850 JW0834 Uncharacterized protein ybjCIntegral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN260.131TMH06.40394-220i12-29o44-68iCytoplasmicMembrane9.8245.74
YGBE_ECOLIP46141
ygbE
b2749 JW2719 Inner membrane protein ygbEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.233TMH010.6872-330o23-46i53-79o85-106iCytoplasmicMembrane10
DDG_ECOLIP0ACV2
lpxP

ddg

ddgb2378 JW2375 Protein ddgExhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384Integral Inner Membrane BBinout/inIM (predicted)Cell inner membrane | Single-pass membrane proteinMembrane anchoredSRPYidCyesyesN490.166TMH01.68704-110o20-46iCytoplasmicMembrane9.829.41
LAPA_ECOLIP0ACV4
yciS
b1279 JW1271 Inner membrane protein yciSIntegral inner membrane (experimental). Heat shock protein involved in the assembly of LPS. In pull-down experiments, LapA and LapB co-purified with LPS, Lpt proteins, FtsH (protease), DnaK, and DnaJ (chaperones). A specific interaction was also observed between WaaC and LapB. LapB potentially coordinates assembly of proteins involved in LPS synthesis at the plasma membrane and regulates turnover of LpxC. PMID: 25403562 Heat shock protein involved in the assembly of LPS. In pull-down experiments, LapA and LapB co-purified with LPS, Lpt proteins, FtsH (protease), DnaK, and DnaJ (chaperones). PMID: 25403562PMID: 15919996 PMID: 25403562Integral Inner Membrane BBinoutout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN230.34TMH011.7404-21Yn4-16c21/22o45-67iCytoplasmicMembrane1036.3
YDGC_ECOLIP0ACX0
ydgC
b1607 JW1599 Inner membrane protein ydgCIntegral inner membrane (experimental). Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996PMID: 15919996 PMID: 24688744 PMID: 16429150Integral Inner Membrane BBpoly, Bmultiin/out, out/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN220.169TMH03.73379-43Yn7-17c21/22o31-47i59-79o85-108iCytoplasmicMembrane1023.69
YEBS_ECOLIP0AD03
yebS
b1833 JW1822 Inner membrane protein yebSIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN570.112CYT0-0.200913-880i66-84o120-141i162-179o185-208i266-291o311-339i360-378o384-406iCytoplasmicMembrane10
YEHU_ECOLIP0AD14
yehU
b2126 JW5353 Inner membrane protein yehUIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN220.144TMH06.36838-660i7-24o44-62i74-93o105-129i141-163o175-195iCytoplasmicMembrane102.15
RSEC_ECOLIP46187
rseC
b2570 JW2554 Sigma-E factor regulatory protein rseCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.187CYT0-0.200913-220i79-98o104-121iCytoplasmicMembrane1027.4
AAEX_ECOLIP46478
aaeX

yhcR

yhcRb3242 JW5541 Protein AaeXIntegral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.106TMH010.7464-220o6-31i43-62oCytoplasmicMembrane9.8234.45
YQGD_ECOLIP46879
yqgD
b2941 JW2908 Uncharacterized protein yqgDIntegral Inner Membrane BBinoutout/inIM (predicted)Integral Membrane ProteinSRPSECpseudogene (Ecogene)nonoN620.118TMH01.01241-210o27-50iCytoplasmicMembrane9.82
YEJM_ECOLIP0AD27
yejM

yejN

yejNb2188 JW2176 Inner membrane protein yejMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN680.133TMH014.6981-550i21-39o51-73i85-103o135-157i169-191oCytoplasmicMembrane102.24
YFCA_ECOLIP0AD30
yfcA
b2327 JW2324 UPF0721 transmembrane protein yfcAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN540.218TMH011.5476-780i7-28o53-73i85-105o111-127i139-158o164-183i195-217o237-255iCytoplasmicMembrane10
YFHB_ECOLIP0AD42
yfhB
b2560 JW5408 Uncharacterized protein yfhB Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 25403562 PMID: 25403562Integral Inner Membrane BBinout/inIM (predicted)Membrane anchoredSRPSECYfgMnoyesN520.106CYT0-0.200913-110o36-54iCytoplasmicMembrane9.828.32
PBP2_ECOLIP0AD65
mrdA

pbpA

pbpAb0635 JW0630 Penicillin-binding protein 2 (PBP-2)Inner membrane (experimental).PMID: 1103132 PMID: 15919657Integral Inner Membrane BBoutin/outIM (predicted), Soluble IM Fraction, Detected in IM FractionCell inner membrane | Peripheral membrane proteinMembrane anchoredSRPSECyesyesN370.174CYT0-0.200913-110i21-40oCytoplasmicMembrane9.828.4
FTSI_ECOLIP0AD68
ftsI

pbpB

pbpBb0084 JW0082 Peptidoglycan synthase ftsI (EC 2.4.1.129) (Penicillin-binding protein 3) (PBP-3) (Peptidoglycan glycosyltransferase 3)Septal ring. Inner membrane.The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein. Localizes to potential division sites in filamentous cells. Interacts directly with FtsN and ZapA. The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex.PMID: 11703663 PMID: 20497333 PMID: 20847002Integral Inner Membrane BBoutin/outSoluble IM FractionCell inner membrane | Single-pass membrane protein | Periplasmic sideMembrane anchoredSRPSECyesyesN370.141SpI453.45111-110i20-44oCytoplasmicMembrane9.9722.11
YPJK_ECOLIP52134
ypjK
b2635 JW5888 Uncharacterized protein ypjKIntegral Inner Membrane BBinoutout/inIM (predicted)Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)nonoN460.265TMH05.94794-31Yn3-14c22/23o46-68iCytoplasmicMembrane10
BRNQ_ECOLIP0AD99
brnQ
b0401 JW0391 Branched-chain amino acid transport system 2 carrier protein (LIV-II)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN250.304TMH015.0757-12120i12-29o41-64i76-98o118-138i150-171o191-212i224-246o281-307i314-333o339-359i371-389o409-426iCytoplasmicMembrane10
LOLC_ECOLIP0ADC3
lolC

ycfU

ycfUb1116 JW5161 Lipoprotein-releasing system transmembrane protein lolCIntegral Membrane ProteinPMID: 15276320 PMID: 10783239Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN190.179TMH02.37377-450o25-48i269-290o310-336i343-360o366-385iCytoplasmicMembrane1029.76
LPTG_ECOLIP0ADC6
lptG

yjgQ

yjgQb4262 JW5760 Lipopolysaccharide export system permease protein lptGIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN360.105TMH04.7678-660i12-33o66-84i105-125o279-298i305-322o334-356iCytoplasmicMembrane109.06
YJJP_ECOLIP0ADD5
yjjP
b4364 JW5796 Inner membrane protein yjjPIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN280.178CYT0-0.200913-350i114-135o141-158i170-189o195-214i226-252oCytoplasmicMembrane1016.1
NEPI_ECOLIP0ADL1
nepI

yicM

yicMb3662 JW5938 Purine ribonucleoside efflux pump nepIIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN480.151TMH08.80109-12120i21-44o56-75i87-106o112-133i145-164o176-196i217-239o254-275i282-301o307-329i341-363o369-389iCytoplasmicMembrane10
YJJZ_ECOLIP55914
yjjZ
b4567 JW5797 Uncharacterized protein yjjZIntegral Inner Membrane BBpolyin/outIM (predicted)Integral Membrane ProteinSRPSECyesyesN260.223TMH09.90172-330i7-25o31-48i55-75oCytoplasmicMembrane9.8219.7
BLR_ECOLIP56976
blr
b4409 JW5963 Beta-lactam resistance proteinCell inner membrane Cell inner membraneSmall membrane protein detected experimentally.PMID: 19121005 PMID: 10931331 PMID: 22885295Integral Inner Membrane BBoutin/outIM (predicted)Cell inner membrane | Single-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN270.106CYT0-0.200913-110i7-26oCytoplasmicMembrane10
YMGF_ECOLIP58034
ymgF
b4520 JW1156 Uncharacterized protein ymgFCell inner membranePMID: 18978050Integral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECnoyesN370.129TMH00.559611-220i12-31o37-59iCytoplasmicMembrane9.8224.68
YOHJ_ECOLIP60632
yohJ
b2141 JW2129 UPF0299 membrane protein yohJIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN300.138TMH013.9988-440i12-32o38-55i67-86o92-113iCytoplasmicMembrane1015.71
YIGM_ECOLIP0ADP5
yigM
b3827 JW3803 Uncharacterized membrane protein yigMIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN200.164TMH06.74192-109Yn2-13c19/20o29-47i59-81o87-105i112-130o136-158i170-190o202-222i234-253o259-276iCytoplasmicMembrane10
YIID_ECOLIP0ADQ2
yiiD
b3888 JW3859 Uncharacterized protein yiiDCopurifies with trigger factor in pull down assays.PMID: 19737520Integral Inner Membrane BBinoutout/inIM (predicted)CytoplasmicSRP,TFSECnoyesN290.101CYT0-0.200913-010o219-240iCytoplasmic8.9653.85
YQAA_ECOLIP0ADR0
yqaA
b2689 JW2664 Inner membrane protein yqaAIntegral inner membrane (experimental).Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. PMID: 15919996PMID: 15919996 PMID: 23086209Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN190.233TMH05.40517-43Yn4-12c17/18o41-65i86-110o116-141iCytoplasmicMembrane104.67
YGIM_ECOLIP0ADT8
ygiM
b3055 JW3027 Uncharacterized protein ygiMIntegral Inner Membrane BBinoutout/inIM (predicted), Detected in IM FractionMembrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesY230.542SpI2218.2018-11Yn6-17c22/23o173-195iUnknown2.512.61
LPTC_ECOLIP0ADV9
lptC

yrbK

yrbKb3199 JW3166 Lipopolysaccharide export system protein lptCCell inner membrane Cell inner membraneEcholocation says Signal peptide may be membrane anchored or cleaved and the protein therefore exported (signalP score near threshold)PMID: 18424520 PMID: 20720015Integral Inner Membrane BBoutin/outSoluble IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN260.212SpI257.46611-10Yn7-18c27/28oUnknown251.41
YHCB_ECOLIP0ADW3
yhcB
b3233 JW5539 Putative cytochrome d ubiquinol oxidase subunit 3 (EC 1.10.3.-) (Cytochrome bd-I oxidase subunit III)Inner membrane (experimental). Inner membraneHas been isolated from inner membrane preparations in a complex with one subunit each of CydA and CydB, suggesting that YhcB is in fact a subunit of the cytochrome bd ubiquinol oxidase complex. YhcB was demonstrated to interact with RodZ as well as several other proteins involved in cell shape maintenance and an inner membrane protein YciS of unknown function, using bacterial two-hybrid system.These observations seem to indicate that YhcB is involved in the biogenesis of cell envelope and the maintenance of cell shape together with RodZ. PMID: 16079137 PMID: 21210718 PMID: 15919657 Binout/inIM (predicted), Detected in IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN210.134CYT0-0.200913-110o6-24iCytoplasmicMembrane9.8283.09
YPFJ_ECOLIP64429
ypfJ
b2475 JW2460 Uncharacterized protein ypfJIntegral Inner Membrane BBoutin/outIM (predicted)Membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN330.101CYT0-0.200913-110i38-58oUnknown2
YBJM_ECOLIP64439
ybjM
b0848 JW0832 Inner membrane protein ybjMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN340.187TMH012.0012-440i7-28o40-57i64-83o95-117iCytoplasmicMembrane1052.86
PPID_ECOLIP0ADY1
ppiD

ybaU

ybaUb0441 JW0431 Peptidyl-prolyl cis-trans isomerase D (PPIase D) (EC 5.2.1.8) (Rotamase D)Inner membrane, Periplasmic side Membrane anchored By in vivo and in vitro site-directed cross-linking, it has been demostrated that the periplasmic chaperone PpiD is located in front of the lateral gate of SecY, through which transmembrane domains exit the SecY channel. Blue native PAGE analyses verify the presence of a SecYEG-PpiD complex in native Escherichia coli membranes. PMID: 24951590 Consistent with a coupling between translocation across the SecYEG translocon and folding by periplasmic chaperones, a lack of PpiD retards the release of a translocating outer membrane protein into the periplasm. PMID: 18439025PMID: 16079137 PMID: 9670013 PMID: 24951590 PMID: 18439025Integral Inner Membrane BBoutin/outIM (predicted), Detected in IM FractionCell inner membrane | Single-pass type II membrane protein | Periplasmic sideMembrane anchored (Experimental)SRPSECyesyesN430.199TMH03.55242-110i12-35oCytoplasmicMembrane1052.9
YAJC_ECOLIP0ADZ7
yajC
b0407 JW0397 UPF0092 membrane protein yajCCell inner membrane Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338PMID: 16079137 PMID: 21541338Integral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN170.156TMH0-0.000234246-110o20-39iCytoplasmicMembrane1041.19
AMPE_ECOLIP0AE14
ampE
b0111 JW0107 Protein AmpEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN230.115CYT0-0.200913-44Yn2-12c16/17o40-58i65-85o148-168i266-283oCytoplasmicMembrane103.49
AMPG_ECOLIP0AE16
ampG
b0433 JW0423 Protein AmpGIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN380.305TMH012.6077-14140i15-38o44-61i82-101o107-131i143-165o177-195i225-250o262-281i288-309o321-342i354-376o382-402i423-445o465-485iCytoplasmicMembrane10
YCEO_ECOLIP64442
yceO
b1058 JW1045 Uncharacterized protein yceOSmall membrane protein detected experimentally.PMID: 19121005Integral Inner Membrane BBinoutin/outIM (predicted)Membrane anchoredSRPSECnoyesN160.097CYT0-0.200913-110i25-45oCytoplasmicMembrane9.82
YNAJ_ECOLIP64445
ynaJ
b1332 JW1326 Uncharacterized protein ynaJIntegral Inner Membrane BBoutin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN330.241TMH015.6597-21Yn15-26c31/32o55-80iCytoplasmicMembrane9.8229.56
YDCX_ECOLIP64453
ydcX
b1445 JW5232 Uncharacterized protein ydcXIntegral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN190.119TMH010.662-220o6-25i37-56oCytoplasmicMembrane9.82
ARAE_ECOLIP0AE24
araE
b2841 JW2809 Arabinose-proton symporter (Arabinose transporter)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN450.136TMH07.37397-12120i23-51o63-84i91-110o116-137i149-167o179-198i258-281o297-317i329-348o360-384i405-422o428-446iCytoplasmicMembrane10
ARAH_ECOLIP0AE26
araH
b4460 JW1887 L-arabinose transport system permease protein AraHIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCpseudogene (Ochman & Davalos, 2006)noyesN470.147TMH013.0464-9100i21-42o54-72i79-96o102-124i131-150o170-191i222-240o252-269i276-295o301-317iCytoplasmicMembrane10
ARTM_ECOLIP0AE30
artM
b0861 JW0845 Arginine ABC transporter permease protein ArtMIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN270.106TMH012.0162-550o20-39i51-70o82-100i155-176o188-211iCytoplasmicMembrane10
ARTQ_ECOLIP0AE34
artQ
b0862 JW0846 Arginine ABC transporter permease protein ArtQIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN300.173TMH017.1037-450o12-35i42-68o101-118i161-182o202-223iCytoplasmicMembrane1026.25
YTFL_ECOLIP0AE45
ytfL
b4218 JW4177 UPF0053 inner membrane protein ytfLIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.622SpI269.49148-43Yn5-18c26/27o56-80i100-119o139-162iCytoplasmicMembrane1048.28
YDHI_ECOLIP64471
ydhI
b1643 JW1635 Uncharacterized protein ydhIIntegral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN320.128TMH010.2168-220o20-44i56-77oCytoplasmicMembrane9.8243.86
YDJM_ECOLIP64481
ydjM
b1728 JW5281 Inner membrane protein ydjMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN280.333CYT0-0.200913-04Yn7-17c22/23o32-48i69-90o110-128i149-166oCytoplasmicMembrane1015.67
CITT_ECOLIP0AE74
citT

ybdS

ybdSb0612 JW0604 Citrate carrier (Citrate transporter) (Citrate/succinate antiporter)Integral Membrane ProteinPMID: 9696764Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN580.164TMH013.6692-13140i7-27o33-50i57-74o94-117i138-155o161-178i190-213o233-259i288-304o310-329i341-361o381-412i424-443o463-486iCytoplasmicMembrane10
CPXA_ECOLIP0AE82
cpxA

ecfB eup ssd

ecfB eup ssdb3911 JW3882 Sensor protein CpxA (EC 2.7.13.3)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN190.111TMH01.20569-220o6-27i165-184oCytoplasmicMembrane1016.7
CYOE_ECOLIP0AEA5
cyoE
b0428 JW0418 Protoheme IX farnesyltransferase (EC 2.5.1.-) (Heme B farnesyltransferase) (Heme O synthase)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN580.11TMH02.59686-990i12-30o36-60i80-102o108-127i134-156o162-183i209-227o233-252i264-285oCytoplasmicMembrane10
CYSW_ECOLIP0AEB0
cysW
b2423 JW2416 Sulfate transport system permease protein cysWIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.154TMH013.7791-660i20-43o63-89i101-124o144-162i202-228o248-268iCytoplasmicMembrane1052.07
YNAI_ECOLIP0AEB5
ynaI
b1330 JW1323 MscS family inner membrane protein ynaICell inner membrane Integral inner membrane (experimental).PMID: 22874652 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN220.127TMH07.65863-450o12-30i42-65o77-96i117-134o140-159iCytoplasmicMembrane1014.54
YEAQ_ECOLIP64485
yeaQ
b1795 JW1784 UPF0410 protein yeaQIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN180.108TMH015.2932-330o6-21i28-52o58-77iCytoplasmicMembrane10
YEBO_ECOLIP64499
yebO
b1825 JW1814 Uncharacterized protein yebOIntegral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN360.143CYT0-0.200913-110o12-32iUnknown246.45
YOAE_ECOLIP0AEC0
yoaE
b1816 JW1805 UPF0053 inner membrane protein yoaEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.115TMH01.99313-770o12-36i48-69o81-101i122-148o154-172i184-207o213-231iCytoplasmicMembrane1010.84
ARCB_ECOLIP0AEC3
arcB
b3210 JW5536 Aerobic respiration control sensor protein ArcB (EC 2.7.13.3)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN360.18TMH09.51619-220o20-46i58-77oCytoplasmicMembrane10
BARA_ECOLIP0AEC5
barA
b2786 JW2757 Signal transduction histidine-protein kinase BarA (EC 2.7.13.3)Cell inner membraneExhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCnoyesN340.123TMH07.64299-220o12-31i177-199oCytoplasmicMembrane1056.26
MGRB_ECOLIP64512
mgrB

yobG

yobGb1826 JW1815 Protein mgrBSmall membrane protein detected experimentally. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ.PMID: 19121005 PMID: 20041203Integral Inner Membrane BBinoutin/outN/APeriplasmicSECnoyesN220.24SpI2110.2239-10Yn6-17c21/22oCytoplasmicMembrane9.8653.79
YEIS_ECOLIP64536
yeiS
b2145 JW5359 Uncharacterized protein yeiSIntegral Inner Membrane B-IM (predicted)Membrane | Single-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN240.124TMH02.78571-220o6-24i54-77oCytoplasmicMembrane9.8257.44
YFGG_ECOLIP64545
yfgG
b2504 JW5399 Uncharacterized protein yfgGIntegral Inner Membrane BBinoutin/outN/AMembrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN410.141TMH03.8997-10Yn20-31c39/40oCytoplasmicMembrane9.82
DCUS_ECOLIP0AEC8
dcuS

yjdH

yjdHb4125 JW4086 Uncharacterized protein yjeNIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCnoyesN480.105TMH05.80308-220i21-41o183-205iCytoplasmicMembrane1035.3
DPPB_ECOLIP0AEF8
dppB
b3543 JW3512 Dipeptide transport system permease protein dppBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.168TMH06.13051-660i9-30o100-123i135-160o201-221i259-285o305-331iCytoplasmicMembrane10
DPPC_ECOLIP0AEG1
dppC
b3542 JW3511 Dipeptide transport system permease protein dppCIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN590.13TMH00.391748-550o32-53i102-127o147-173i215-244o264-287iCytoplasmicMembrane104.14
RSEP_ECOLIP0AEH1
rseP

ecfE yaeL

ecfE yaeLb0176 JW0171 Regulator of sigma E protease (EC 3.4.24.-)Cell inner membrane Cell inner membrane Cell inner membrane Cell inner membraneFluorescent fusions of RseP have been monitored via fluorescence microscopy. RseP has been found to generally associated with the membrane.PMID: 17272300 PMID: 11689431 PMID: 11750129 PMID: 11867724 PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.109TMH03.00034-440o6-29i98-119o376-396i426-444oCytoplasmicMembrane1016.14
AlaE_ECOLIP64550
alaE

ygaW

ygaWb2670 JW2645 Uncharacterized protein ygaWCell inner membranePMID: 21531828Integral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN490.117TMH06.24909-440i12-36o42-62i82-104o110-131iCytoplasmicMembrane1012.19
YGGT_ECOLIP64564
yggT
b2952 JW2919 Uncharacterized protein yggTIntegral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECYfgMyesyesN310.194TMH00.565687-440o6-25i67-91o97-119i144-165oCytoplasmicMembrane105.26
YQJE_ECOLIP64585
yqjE
b3099 JW3070 Inner membrane protein yqjEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN620.126CYT0-0.200913-220i50-76o82-104iCytoplasmicMembrane10
ELAB_ECOLIP0AEH5
elaB

yfbD

yfbDb2266 JW2261 Protein elaBRibosomeElaB is an YqjD paralog and also has transmembrane motif at the C-terminal region. ElaB is an YqjD paralog and also has transmembrane motif at the C-terminal region. Probably binds to the membrane and ribosomes in a manner similar to that of YqjD PMID: 22661687.PMID: 22661687Integral Inner Membrane BBoutout/inIM (predicted), Detected in IM FractionMembrane anchoredSRPSECyesyesN330.125CYT0-0.200913-110o81-99iUnknown299.87
EMRB_ECOLIP0AEJ0
emrB
b2686 JW2661 Multidrug resistance protein BIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC. PMID: 15919996PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPYidCyesyesN360.208TMH05.07213-13130i12-33o53-72i81-100o106-128i140-161o167-189i201-220o232-251i272-291o303-324i336-353o365-390i480-498oCytoplasmicMembrane10
ENVZ_ECOLIP0AEJ4
envZ

ompB perA tpo

ompB perA tpob3404 JW3367 Osmolarity sensor protein envZ (EC 2.7.13.3)Integral inner membrane (experimental).Contains HAMP an intrinsically disordered domain. EnvZ HAMP domain by itself is unable to form a stable structure and that this structural fragility may be important for its role in signal transduction. PMID: 2668953 PMID: 15522865 PMID: 17635923 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.263TMH07.11037-220i12-39o160-179iCytoplasmicMembrane10
FDNI_ECOLIP0AEK7
fdnI
b1476 JW1472 Formate dehydrogenase, nitrate-inducible, cytochrome b556(fdn) subunit (Anaerobic formate dehydrogenase cytochrome b556 subunit) (Formate dehydrogenase-N subunit gamma) (FDH-N subunit gamma) Alpha-helcal transmembrane protein (experimental). Transmembrane helices: 3. Integral inner membrane (experimental). PMID: 15342602 PMID: 11266632 PMID: 11884747 PMID: 15919996 PMID: 11929547Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN370.156TMH022.1464-440i21-43o55-76i117-138o150-174iCytoplasmicMembrane1035.28
YHAH_ECOLIP64590
yhaH
b3103 JW3074 Inner membrane protein yhaHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.122TMH08.08221-330o23-40i52-70o82-103iCytoplasmicMembrane108.9
YHAI_ECOLIP64592
yhaI
b3104 JW3075 Inner membrane protein yhaIIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.264TMH00.961473-330i23-44o50-68i80-98oCytoplasmicMembrane1028.42
YHDU_ECOLIP64619
yhdU
b3263 JW3231 Uncharacterized protein yhdUPotential Signal PeptideIntegral Inner Membrane BBinoutin/outIM (predicted)Membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN310.117TMH00.197917-10Yn7-18c30/31oCytoplasmicMembrane9.8282.37
YHFU_ECOLIP64631
yhfU
b3378 JW5697 Uncharacterized protein yhfUIntegral Inner Membrane BBinoutout/inN/AMembrane anchoredSRPSECnoyesN370.114CYT0-0.200913-110o47-69iUnknown290.44
FDOI_ECOLIP0AEL0
fdoI
b3892 JW3863 Formate dehydrogenase, cytochrome b556(fdo) subunit (Aerobic formate dehydrogenase cytochrome b556 subunit) (FDH-Z subunit gamma) (Formate dehydrogenase-O subunit gamma)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN290.115TMH016.4965-440i20-43o55-73i113-133o145-172iCytoplasmicMembrane1016.96
GALP_ECOLIP0AEP1
galP
b2943 JW2910 Galactose-proton symporter (Galactose transporter)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.158TMH014.2152-12120i15-44o56-77i84-103o109-130i142-160o172-192i251-274o290-310i322-342o348-373i385-406o418-436iCytoplasmicMembrane10
GLNP_ECOLIP0AEQ6
glnP
b0810 JW0795 Glutamine transport system permease protein glnPIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.119TMH07.24978-350o23-42i54-78o90-113i125-144o190-209iCytoplasmicMembrane10
GLPF_ECOLIP0AER0
glpF
b3927 JW3898 Glycerol uptake facilitator protein (Aquaglyceroporin) Outer membrane. Integral inner membrane (experimental).PMID: 11266632 PMID: 11039922 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.125TMH09.6263-660i12-34o46-79i86-108o145-166i178-202o230-251iCytoplasmicMembrane10
GLTJ_ECOLIP0AER3
gltJ
b0654 JW0649 Glutamate/aspartate transport system permease protein gltJIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.108TMH09.38551-550o24-50i71-88o108-127i179-199o211-233iCytoplasmicMembrane10
YRFC_ECOLIP64634
hofN

yrfC

yrfCb3394 JW3357 Uncharacterized protein yrfCIntegral Inner Membrane BBoutin/outN/AMembrane anchoredSRPSECyesyesN490.175TMH03.72613-110i21-40oCytoplasmicMembrane9.8222.14
YJDO_ECOLIP64646
yjdO

yjdO

yjdOb4559 JW5732 Uncharacterized protein yjdOToxin-antitoxin system Ghot-GhoS.In vitro RNA degradation studies, quantitative real-time reverse-transcription PCR and whole-transcriptome studies revealed that GhoS masks GhoT toxicity by cleaving specifically yjdO (ghoT) mRNA.PMID: 22941047Integral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN330.1TMH09.94204-220i7-26o32-56iCytoplasmicMembrane9.82
YHGN_ECOLIP67143
yhgN
b3434 JW3397 UPF0056 inner membrane protein yhgNIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN260.114CYT0-0.200913-660o6-27i39-57o63-85i106-127o139-162i174-195oCytoplasmicMembrane1037.49
GLTK_ECOLIP0AER5
gltK
b0653 JW0648 Glutamate/aspartate transport system permease protein gltKIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.129TMH07.84867-550o20-44i65-83o95-112i153-178o198-219iCytoplasmicMembrane10
GLTS_ECOLIP0AER8
gltS

gltC

gltCb3653 JW3628 Sodium/glutamate symport carrier protein (Glutamate permease)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN270.145CYT0-0.200913-911Yn7-18c26/27o36-52i72-90o96-119i126-148o160-184i215-239o245-268i275-297o303-323i335-357o369-394iCytoplasmicMembrane10
HDED_ECOLIP0AET5
hdeD

yhiA

yhiAb3511 JW3479 Protein hdeDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.139TMH03.36767-660i23-42o48-69i76-97o103-124i136-155o161-187iCytoplasmicMembrane10
HISM_ECOLIP0AEU3
hisM
b2307 JW2304 Histidine transport system permease protein hisMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.123TMH010.1822-430o20-45i57-79o200-221iCytoplasmicMembrane10
HYFE_ECOLIP0AEW1
hyfE
b2485 JW2470 Hydrogenase-4 component E (EC 1.-.-.-)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN540.165TMH04.55769-770o6-24i31-54o60-80i92-114o126-143i152-171o177-196iCytoplasmicMembrane10
KGTP_ECOLIP0AEX3
kgtP

witA

witAb2587 JW2571 Alpha-ketoglutarate permeaseIntegral inner membrane (experimental).Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECnoyesN90.105TMH02.8422-12120i21-42o62-84i96-116o122-139i160-183o195-214i244-266o278-299i311-331o337-360i372-393o405-423iCytoplasmicMembrane10
YQHA_ECOLIP67244
yqhA
b3002 JW2971 UPF0114 protein yqhAIntegral Membrane ProteinPMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN320.15TMH06.53453-340o12-32i53-75o109-126i138-156oCytoplasmicMembrane1015.29
YOBD_ECOLIP67601
yobD
b1820 JW1809 UPF0266 membrane protein yobDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.285TMH03.32601-230o6-24i45-62o68-87iCytoplasmicMembrane10
LIVH_ECOLIP0AEX7
livH
b3457 JW3422 High-affinity branched-chain amino acid transport system permease protein livH (LIV-I protein H)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN450.186TMH016.6878-880o20-39i46-64o70-89i105-122o158-175i204-230o242-270i282-301oCytoplasmicMembrane10
MARC_ECOLIP0AEY1
marC

ydeB ydeC

ydeB ydeCb1529 JW1522 UPF0056 inner membrane protein marCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN380.16TMH010.7793-550o12-32i44-62o68-89i151-172o192-214iCytoplasmicMembrane105
MDFA_ECOLIP0AEY8
mdfA

cmlA cmr

cmlA cmrb0842 JW0826 Multidrug translocase mdfA (Chloramphenicol resistance pump cmr)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN320.122TMH06.20433-12120i15-33o53-72i84-103o109-130i142-164o170-188i221-246o258-275i287-308o314-335i347-367o379-399iCytoplasmicMembrane10
MODB_ECOLIP0AF01
modB

chlJ

chlJb0764 JW0747 Uncharacterized protein yjhHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN340.137TMH08.18777-550o20-37i49-70o90-115i136-158o198-220iCytoplasmicMembrane1020.17
MOTB_ECOLIP0AF06
motB
b1889 JW1878 Motility protein B (Chemotaxis protein MotB)Cell inner membrane Membrane anchored Integral inner membrane MotB has one membrane-spanning alpha-helix but the majority of the molecule is in the periplasmic space with a peptidoglycan-binding domain near its C-terminus PMID: 2447650PMID: 19364805 PMID: 23193105 PMID: 2447650 PMID: 12730325 PMID: 2447650Integral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell inner membrane | Single-pass type II membrane proteinMembrane anchored (Experimental)SRPSECyesyesN320.155CYT0-0.200913-110o28-47iCytoplasmicMembrane7.8833.3
MDTI_ECOLIP69210
mdtI

ydgE

ydgEb1599 JW1591 Spermidine export protein mdtIIntegral inner membrane (experimental).PMID: 15919996 PMID: 24688744Integral Inner Membrane BBpoly, Bmultiout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN560.185TMH03.45748-440o6-25i37-56o62-84i91-108oCytoplasmicMembrane1014.92
MDTJ_ECOLIP69212
mdtJ

ydgF

ydgFb1600 JW1592 Spermidine export protein mdtJIntegral inner membrane (experimental).PMID: 15919996 PMID: 24688744Integral Inner Membrane BBpoly, Bmultiout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.125TMH07.68505-43Yn3-13c21/22o31-52i59-80o86-102iCytoplasmicMembrane1036.97
PGAD_ECOLIP69432
pgaD

ycdP

ycdPb1021 JW1006 Biofilm PGA synthesis protein PgaDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN380.135TMH010.5144-220i16-36o56-74iCytoplasmicMembrane109.97
MURJ_ECOLIP0AF16
murJ

mviN yceN

mviN yceNb1069 JW1056 Virulence factor mviN homologCell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN220.165SpI230.241812-13130o27-45i82-110o130-154i161-182o188-205i236-262o274-292i313-334o354-371i383-402o408-429i441-466o478-501iCytoplasmicMembrane10
NARV_ECOLIP0AF32
narV
b1465 JW1460 Respiratory nitrate reductase 2 gamma chain (EC 1.7.99.4)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.114TMH010.9916-550o12-29i50-69o89-111i132-151o180-199iCytoplasmicMembrane10
YJBB_ECOLIP0AF43
yjbB
b4020 JW3980 Uncharacterized protein yjbBIntegral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN240.13TMH01.33234-88Yn2-13c17/18o45-64i76-98o104-121i133-151o171-194i206-226o238-262i274-294oCytoplasmicMembrane104.03
YJCD_ECOLIP0AF52
yjcD
b4064 JW4025 Putative permease yjcDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN590.114CYT0-0.200913-13130i29-49o55-74i81-101o107-129i141-165o171-195i202-220o256-280i301-321o333-350i357-378o390-416i428-448oCytoplasmicMembrane10
LPTF_ECOLIP0AF98
lptF

yjgP

yjgPb4261 JW4218 Lipopolysaccharide export system permease protein lptFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN380.124CYT0-0.200913-660i16-39o59-76i97-119o268-289i296-316o328-348iCytoplasmicMembrane1013.66
PTXB_ECOLIP69789
glvB

glvC

glvCb3682 JW3659 Phosphotransferase enzyme IIB component glvB (EC 2.7.1.69) (PTS system EIIB component)Integral Inner Membrane BBinout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinMembrane anchoredSRPSECpseudogene (Ochman & Davalos, 2006)yesnoN450.17CYT0-0.200913-110o12-31iCytoplasmicMembrane9.8233.58
FBPB_ECOLIP75681
fbpB

afuB

afuBb0263 JW0255 Putative ferric transport system permease protein fbpB (Fragment)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoN460.154CYT0-0.200913-220i33-56o76-101iCytoplasmicMembrane9.8230.56
YKGB_ECOLIP75685
ykgB
b0301 JW5038 Inner membrane protein ykgBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN410.117TMH00.0510112-340i12-32o87-105i112-133o153-175iCytoplasmicMembrane10
NARX_ECOLIP0AFA2
narX

narR

narRb1222 JW1213 Nitrate/nitrite sensor protein narX (EC 2.7.13.3)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN470.224SpI334.68578-220i12-36o154-174iCytoplasmicMembrane1044.11
NFRB_ECOLIP0AFA5
nfrB
b0569 JW0558 Bacteriophage N4 adsorption protein BCell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN200.134CYT0-0.200913-440o12-42i365-384o390-410i422-443oCytoplasmicMembrane107.03
NHAB_ECOLIP0AFA7
nhaB
b1186 JW1175 Na(+)/H(+) antiporter nhaB (Sodium/proton antiporter nhaB)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN440.149TMH010.0118-12120o20-47i59-77o89-108i120-141o147-165i202-219o239-260i299-331o351-368i389-413o453-471i478-498oCytoplasmicMembrane10
NIKC_ECOLIP0AFA9
nikC
b3478 JW3443 Nickel transport system permease protein nikCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN250.156TMH010.244-660i12-32o75-100i121-148o177-196i203-222o242-260iCytoplasmicMembrane10
YBBV_ECOLIP75711
ybbV
b0510 JW0498 Protein hokBIntegral Inner Membrane BBinout/inIM (predicted)Membrane anchoredSRPSECnoyesN610.11CYT0-0.200913-110o15-33iUnknown2
RZPD_ECOLIP75719
rzpD

ybcT

ybcTb0556 JW5079 Putative Rz endopeptidase from lambdoid prophage DLP12 (EC 3.4.-.-)Required for normal curli expression and biofilm development.PMID: 23378572Integral Inner Membrane B-N/APeriplasmicSRPSECProphage Integrase (EcoGene)nonoN230.233SpI223.631-10Yn6-17c22/23oUnknown228.64
YBHM_ECOLIP75769
ybhM
b0787 JW0770 Uncharacterized protein ybhMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN410.18TMH04.77792-770i21-41o53-70i77-98o104-129i136-155o161-179i209-229oCytoplasmicMembrane1067.12
NUOA_ECOLIP0AFC3
nuoA
b2288 JW2283 NADH-quinone oxidoreductase subunit A (EC 1.6.99.5) (NADH dehydrogenase I subunit A) (NDH-1 subunit A) (NUO1)Cell inner membrane Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338PMID: 15919996 PMID: 21541338Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN440.182TMH012.5237-330o12-37i68-88o100-122iCytoplasmicMembrane1048.69
NUOH_ECOLIP0AFD4
nuoH
b2282 JW2277 NADH-quinone oxidoreductase subunit H (EC 1.6.99.5) (NADH dehydrogenase I subunit H) (NDH-1 subunit H) (NUO8)Integral inner membrane (experimental).PMID: 20732298 PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN330.139TMH07.32865-890i12-32o52-69i81-100o112-133i154-174o186-207i234-257o269-289i301-322oCytoplasmicMembrane10
NUOJ_ECOLIP0AFE0
nuoJ
b2280 JW2275 NADH-quinone oxidoreductase subunit J (EC 1.6.99.5) (NADH dehydrogenase I subunit J) (NDH-1 subunit J) (NUO10)Integral inner membrane (experimental).PMID: 20732298 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN290.504TMH010.2272-54Yn3-14c18/19o28-49i56-74o94-112i133-158oCytoplasmicMembrane1082.78
NUOK_ECOLIP0AFE4
nuoK
b2279 JW2274 NADH-quinone oxidoreductase subunit K (EC 1.6.99.5) (NADH dehydrogenase I subunit K) (NDH-1 subunit K) (NUO11)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 20732298 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.166TMH08.16488-330o6-24i29-54o60-81iCytoplasmicMembrane10
NUOM_ECOLIP0AFE8
nuoM
b2277 JW2272 NADH-quinone oxidoreductase subunit M (EC 1.6.99.5) (NADH dehydrogenase I subunit M) (NDH-1 subunit M) (NUO13)Integral inner membrane (experimental).PMID: 20732298 PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN590.116TMH06.38779-14140o6-23i30-48o77-103i115-134o140-159i180-199o219-244i256-274o286-307i314-333o345-363i383-405o417-440i461-481oCytoplasmicMembrane10
YCAP_ECOLIP75839
ycaP
b0906 JW0889 UPF0702 transmembrane protein ycaPIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN640.104TMH00.694512-330o18-37i49-69o75-96iCytoplasmic8.9626.62
GFCA_ECOLIP75885
gfcA

ymcD

ymcDb0987 JW5133 Threonine-rich inner membrane protein gfcA (Group 4 capsule protein A homolog)Integral inner membrane (experimental).When the protein is over-expressed protein is located on the Inner Membrane.PMID: 15919996Integral Inner Membrane Bout/outIM (predicted)Cell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesY220.858SpI2131.9353-20Yn5-16c21/22oCytoplasmicMembrane10113.93
YCDZ_ECOLIP75916
ycdZ
b1036 JW5147 Inner membrane protein ycdZIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN650.232TMH014.4904-550o20-42i49-70o76-94i99-117o123-147iCytoplasmicMembrane10
NUON_ECOLIP0AFF0
nuoN
b2276 JW2271 NADH-quinone oxidoreductase subunit N (EC 1.6.99.5) (NADH dehydrogenase I subunit N) (NDH-1 subunit N) (NUO14)Integral inner membrane (experimental).PMID: 20732298 PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN610.262TMH09.81822-14140o6-28i35-55o75-93i105-122o128-147i159-181o201-226i238-259o271-290i297-316o328-351i371-394o406-426i447-470oCytoplasmicMembrane10
NUPC_ECOLIP0AFF2
nupC

cru

crub2393 JW2389 Nucleoside permease nupC (Nucleoside-transport system protein nupC)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN270.126TMH00.463943-890o6-23i30-48o87-108i167-187o193-212i242-271o277-298i341-361o381-399iCytoplasmicMembrane10
NUPG_ECOLIP0AFF4
nupG
b2964 JW2932 Nucleoside permease NupGIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN510.127TMH010.0497-12120i12-31o37-58i70-89o95-116i137-155o161-179i211-235o255-275i282-300o306-327i348-369o381-402iCytoplasmicMembrane10
OPPB_ECOLIP0AFH2
oppB
b1244 JW1236 Oligopeptide transport system permease protein oppBIntegral inner membrane (experimental). Peripheral inner membrane protein facing the cytoplasm. Opp-LacZ hybrid proteins were used to show that OppB, OppC and OppD are membrane-associated proteins. PMID: 2821267PMID: 15919996 PMID: 2821267Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN480.124TMH03.13181-660i12-30o100-121i133-161o173-192i228-254o274-300iCytoplasmicMembrane10
YMFA_ECOLIP75962
ymfA
b1122 JW5164 Inner membrane protein ymfAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN290.212TMH06.47267-220i7-28o117-139iCytoplasmicMembrane10
YMFE_ECOLIP75968
ymfE
b1138 JW5166 Uncharacterized protein ymfEIntegral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)nonoN370.102TMH01.7441-440i21-39o59-79i151-173o185-208iCytoplasmicMembrane107.7
Y1142_ECOLIP75971
b1142
b1142 JW1128 Putative uncharacterized protein b1142Integral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECpseudogene (Uniprot), pseudogene (Ecogene), pseudogene (Ochman & Davalos, 2006)nonoN630.119CYT0-0.200913-220i41-62o74-92iUnknown254.37
YMFR_ECOLIP75979
ymfR
b1150 JW1136 Uncharacterized protein ymfRIntegral Inner Membrane BBinoutin/inIM (predicted)Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)nonoN220.153TMH011.0494-21Yn4-17c21/22o31-49iCytoplasmicMembrane9.8216.11
OPPC_ECOLIP0AFH6
oppC
b1245 JW1237 Oligopeptide transport system permease protein oppCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN640.213TMH00.755301-660i40-64o103-128i140-158o164-183i218-247o267-290iCytoplasmicMembrane10
PERM_ECOLIP0AFI9
perM

yfgO

yfgOb2493 JW2478 Putative permease perMIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.135TMH020.7793-770o20-51i72-93o151-177i217-236o242-270i282-301o307-332iCytoplasmicMembrane1026
PITA_ECOLIP0AFJ7
pitA

pit

pitb3493 JW3460 Low-affinity inorganic phosphate transporter 1Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN390.147TMH08.59981-1090o12-32i52-76o96-116i123-143o155-177i208-227o233-255i379-402o474-494iCytoplasmicMembrane10
PNUC_ECOLIP0AFK2
pnuC
b0751 JW0734 Nicotinamide riboside transporter pnuCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.115TMH03.57186-670o22-40i47-65o71-88i109-139o159-178i185-205o211-226iCytoplasmicMembrane10
POTB_ECOLIP0AFK4
potB
b1125 JW1111 Spermidine/putrescine transport system permease protein potBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.107TMH05.71787-670o6-26i54-78o90-108i120-138o144-163i184-214o242-262iCytoplasmicMembrane10
YMGE_ECOLIP76011
ymgE

tag

tagb1195 JW1184 UPF0410 protein ymge (Transglycosylase-associated gene protein)Integral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.106TMH011.3901-330o6-21i28-47o59-81iCytoplasmicMembrane1016.22
YNBA_ECOLIP76090
ynbA
b1408 JW1405 Inner membrane protein ynbAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN500.126TMH0-0.193337-550o31-64i85-107o113-132i152-168o174-191iCytoplasmicMembrane1011.98
YDCZ_ECOLIP76111
ydcZ
b1447 JW1442 Inner membrane protein ydcZIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN610.165TMH08.79151-54Yn4-19c24/25o34-55i67-88o94-114i126-145oCytoplasmicMembrane1014.36
POTC_ECOLIP0AFK6
potC
b1124 JW1110 Spermidine/putrescine transport system permease protein potCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN600.118TMH010.8409-660i12-30o64-86i98-122o128-151i172-195o230-252iCytoplasmicMembrane10
POTI_ECOLIP0AFL1
potI
b0857 JW0841 Putrescine transport system permease protein potIIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.124TMH014.5424-670i12-35o60-90i102-129o141-163i184-206o212-232i244-264oCytoplasmicMembrane10
PQIA_ECOLIP0AFL9
pqiA

pqi5A

pqi5Ab0950 JW0933 Paraquat-inducible protein AIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN330.119CYT0-0.200913-880i53-76o96-122i142-160o166-185i257-277o304-329i350-371o377-400iCytoplasmicMembrane10
YADH_ECOLIP0AFN6
yadH
b0128 JW0124 Inner membrane transport permease yadHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.101TMH08.75539-67Yn4-9c14/15o24-46i58-84o104-132i139-164o170-191i203-221o227-248iCytoplasmicMembrane104.72
YBHR_ECOLIP0AFP9
ybhR
b0792 JW5803 Inner membrane transport permease ybhRIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.153CYT0-0.200913-660i21-41o173-197i218-243o255-277i284-302o345-363iCytoplasmicMembrane10
YNEN_ECOLIP76136
safA

yneN

yneNb1500 JW1494.1 Two-component-system connector protein yneN (Regulatory protein b1500)Cell inner membranePMID: 17998538Integral Inner Membrane BBinout/inIM (predicted)Cell inner membrane | Single-pass type II membrane protein-SRPSECnoyesN400.109CYT0-0.200913-110o19-40iCytoplasmicMembrane9.82
YNEE_ECOLIP76146
yneE
b1520 JW5245 UPF0187 protein yneEIntegral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN380.113TMH013.5444-340i28-46o52-70i208-229o235-255iCytoplasmicMembrane9.82
YDGK_ECOLIP76180
ydgK
b1626 JW1618 Inner membrane protein ydgKIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.147TMH019.3259-440i12-36o56-78i90-108o114-133iCytoplasmicMembrane10
YNIB_ECOLIP76208
yniB
b1726 JW1715 Uncharacterized protein yniBIntegral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN440.107TMH05.0431-340o15-33i45-63o83-101i150-172oCytoplasmicMembrane1040.74
YBHS_ECOLIP0AFQ2
ybhS
b0793 JW0777 Inner membrane transport permease ybhSIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN670.102CYT0-0.200913-660i29-47o182-205i232-255o261-283i295-314o346-370iCytoplasmicMembrane107.64
YCHM_ECOLIP0AFR2
ychM

ychM

ychMb1206 JW5189 Putative sulfate transporter ychMCell inner membrane Integral inner membrane (experimental).PMID: 23278959 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN690.11CYT0-0.200913-1190o33-53i60-80o100-118i130-152o172-198i210-231o278-300i358-388o408-438iCytoplasmicMembrane10
YCJO_ECOLIP0AFR7
ycjO
b1311 JW1304 Inner membrane ABC transporter permease protein ycjOIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.147TMH012.2234-65Yn14-25c30/31o77-98i110-130o163-189i210-233o265-283iCytoplasmicMembrane10
YDCV_ECOLIP0AFR9
ydcV
b1443 JW1438 Inner membrane ABC transporter permease protein ydcVIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN330.134TMH08.81303-660i12-33o71-91i103-127o133-153i189-212o232-256iCytoplasmicMembrane10
LSRD_ECOLIP0AFS1
lsrD

ydeZ

ydeZb1515 JW1508 Uncharacterized protein yjhG (EC 4.-.-.-)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN240.162TMH09.62635-99Yn9-17c23/24o33-56i63-82o88-110i117-140o160-181i212-234o240-260i267-286o292-310iCytoplasmicMembrane10
YNJA_ECOLIP76222
ynjA
b1753 JW1742 Uncharacterized protein ynjAIntegral Inner Membrane BBinout/inIM (predicted)CytoplasmicSRPSECyesyesN260.102CYT0-0.200913-010o33-51iCytoplasmicMembrane9.8241.21
YNJF_ECOLIP76226
ynjF
b1758 JW1747 Inner membrane protein ynjFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN430.114CYT0-0.200913-550o33-60i81-102o114-135i147-167o173-195iCytoplasmicMembrane10
YOAI_ECOLIP76239
yoaI
b1788 JW5885 Xanthosine permease (Xanthosine transporter)Integral Inner Membrane BBinoutout/inIM (predicted)Membrane | Single-pass membrane protein-SRPSECnoyesN210.164CYT0-0.200913-110o6-30iCytoplasmicMembrane9.82
TQSA_ECOLIP0AFS5
tqsA

ydgG

ydgGb1601 JW1593 AI-2 transport protein tqsA (Transport of quorum-sensing signal protein)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.372TMH08.36419-880i12-31o37-55i62-83o144-165i197-218o224-246i258-279o299-325iCytoplasmicMembrane10
YDIK_ECOLIP0AFS7
ydiK
b1688 JW1678 UPF0118 inner membrane protein ydiKIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.172TMH013.7653-990i12-31o37-53i65-86o160-179i191-208o214-235i247-271o277-295i307-334oCytoplasmicMembrane10
YEBA_ECOLIP0AFS9
yebA
b1856 JW5304 Uncharacterized metalloprotease yebA (EC 3.4.24.-) (ORFU)Integral Inner Membrane BBoutin/outIM (predicted)Cell membrane | Single-pass membrane proteinCytoplasmicSRPSECyesyesN120.112CYT0-0.200913-110i21-39oUnknown233.61
YECS_ECOLIP0AFT2
yecS
b1918 JW1903 Inner membrane amino-acid ABC transporter permease protein yecSIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN700.103TMH08.62641-330o21-45i57-78o186-206iCytoplasmicMembrane104.96
YEJB_ECOLIP0AFU0
yejB
b2178 JW2166 Inner membrane ABC transporter permease protein yejBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.157TMH04.74055-660i9-30o135-156i168-194o224-247i282-309o329-355iCytoplasmicMembrane10
LEUE_ECOLIP76249
leuE

yeaS

yeaSb1798 JW1787 Leucine efflux proteinIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN470.141TMH012.792-660o12-32i44-69o81-99i120-142o154-179i191-209oCytoplasmicMembrane10
YEDR_ECOLIP76334
yedR
b1963 JW1946 Inner membrane protein yedRIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN230.118TMH00.40092-230o6-22i43-62o86-109iCytoplasmicMembrane1043.19
YFDY_ECOLIP76521
yfdY
b2377 JW2374 Uncharacterized protein yfdYIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN280.123TMH019.5928-330o6-25i32-49o55-75iCytoplasmicMembrane1058.61
YFBS_ECOLIP0AFU2
yfbS
b2292 JW2289 Uncharacterized transporter yfbSIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN210.196TMH07.38351-10100i5-22o28-45i57-83o95-124i136-155o175-195i470-493o513-538i550-568o588-608iCytoplasmicMembrane10
YIBH_ECOLIP0AFV0
yibH
b3597 JW3571 Inner membrane protein yibHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBoutin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinMembrane anchoredSRPSECyesyesN530.113TMH02.25888-21Yn3-13c18/19o28-49iCytoplasmicMembrane1023.7
RSEA_ECOLIP0AFX7
rseA

mclA yfiJ

mclA yfiJb2572 JW2556 Sigma-E factor negative regulatory proteinIntegral inner membrane protein. Integral inner membrane protein. Cell inner membrane Integral inner membrane. Nucleoid (experimental). Responce to stress complex RpoE-RseA-RseB. Overproduction of N-terminal domain of RseA alone was shown to inhibit σE activity. RseC which is an inner membrane protein, positively modulates σE activity. The periplasmic domain of RseA interacts with RseB while its cytoplasmic domain interacts with RpoE, thereby sequestering RpoE away from the transcription complex. Proteolysis of transmembrane and cytoplasmic portions of RseA by DegS frees the sigma(E) transcription factor. RseB protein, a known negative regulator, inhibits proteolysis by DegS in vitro by binding tightly to the periplasmic domain of RseA. PMID: 17360428 The N-terminal domain of RseA sequesters σE in the cytoplasmic membrane, preventing its association with core RNA polymerase. The C-terminal domain of RseA interacts with RseB, a periplasmic protein. PMID: 11777003 Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA reveals that RseA functions by sterically occluding the two primary binding determinants on sigma(E) for core RNA polymerase. PMID: 12718891PMID: 9159523 PMID: 9159522 PMID: 12183369 PMID: 17360428 PMID: 11777003 PMID: 12718891Integral Inner Membrane B-IM (predicted-detected)Cell membrane | Single-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN620.226CYT0-0.200913-000iUnknown259.17
SANA_ECOLIP0AFY2
sanA

yeiF

yeiFb2144 JW2132 Protein sanASingle pass inner membrane protein.Related to vancomycin resistance and when overexpressed, is able to complement the permeability defects of a vancomycin-susceptible mutant.PMID: 8550448Integral Inner Membrane BBoutin/outN/ACell inner membrane | Single-pass membrane proteinPeriplasmicSRPSECyesyesN230.14TMH06.95693-10Yn5-18c22/23oCytoplasmicMembrane1010.99
YFEZ_ECOLIP76538
yfeZ
b2433 JW2426 Inner membrane protein yfeZIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.118TMH01.95358-440i21-41o61-78i90-110o116-135iCytoplasmicMembrane1040.67
YGAZ_ECOLIP76630
ygaZ
b2682 JW2657 Inner membrane protein ygaZIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN360.194TMH04.25735-560o22-39i51-70o76-94i140-163o175-193i205-238oCytoplasmicMembrane10
YQIJ_ECOLIP76657
yqiJ
b3050 JW3022 Inner membrane protein yqiJIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN390.125TMH03.14983-330i12-35o66-86i98-117oCytoplasmicMembrane1012.35
SBMA_ECOLIP0AFY6
sbmA
b0377 JW0368 Protein sbmAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN300.182TMH018.7145-880i12-30o58-78i85-112o140-164i206-227o239-263i309-326o332-353iCytoplasmicMembrane10
TRKH_ECOLIP0AFZ7
trkH
b3849 JW5576 Trk system potassium uptake protein trkHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)yesyesN410.127TMH06.71344-10110i12-32o38-57i69-90o136-163i184-204o241-262i274-294o331-363i396-417o423-444i456-481oCytoplasmicMembrane10
WZZE_ECOLIP0AG00
wzzE

wzz yifC

wzz yifCb3785 JW5601 Lipopolysaccharide biosynthesis protein wzzEIntegral inner membrane (experimental). Integral Membrane Protein Integral Membrane ProteinPMID: 15919996 PMID: 16816184 PMID: 16199561Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN470.253TMH08.70367-220o31-50i323-342oCytoplasmicMembrane1019.93
SOHB_ECOLIP0AG14
sohB
b1272 JW1264 Probable protease sohB (EC 3.4.21.-)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell inner membrane | Single-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.141CYT0-0.200913-210o12-32iCytoplasmicMembrane108.79
YIBN_ECOLIP0AG27
yibN
b3611 JW3586 Uncharacterized protein yibNInner membrane (experimental).PMID: 15919657Integral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionMembrane anchoredSRPSECyesyesN360.109CYT0-0.200913-110o12-30iUnknown248.32
YZGL_ECOLIP76692
yzgL
b3427 JW3390 Putative uncharacterized protein yzgLIntegral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECpseudogene (Uniprot)nonoN230.127TMH017.4708-220i12-40o46-69iCytoplasmicMembrane1029.62
HOKE_ECOLIP77091
hokE

ybdY

ybdYb4415 JW5084 Protein hokEPotentially toxic protein.PMID: 19121005Integral Inner Membrane BBinoutin/outN/AMembrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN200.132SpI242.84692-10Yn6-24c29/30oPeriplasmic9.9651.96
YKGH_ECOLIP77180
ykgH
b0310 JW0302 Uncharacterized protein ykgHIntegral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN450.104CYT0-0.200913-220i21-42o186-209iUnknown225.47
RHTB_ECOLIP0AG34
rhtB

yigK

yigKb3824 JW5585 Homoserine/homoserine lactone efflux proteinIntegral Membrane ProteinPMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECpseudogene (Ochman & Davalos, 2006)noyesN250.247TMH011.1132-54Yn7-18c23/24o39-65i116-138o144-168i188-205oCytoplasmicMembrane10
RHTC_ECOLIP0AG38
rhtC

yigJ

yigJb3823 JW5586 Threonine efflux proteinIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)yesyesN250.144TMH08.74493-660o6-26i38-63o69-87i119-140o152-174i186-204oCytoplasmicMembrane10
RMUC_ECOLIP0AG71
rmuC

yigN

yigNb3832 JW3809 DNA recombination protein rmuCSingle-pass integral inner membrane proteinBased on the fact that RmuC is a DNA recombination enzyme we conluded that its N-terminus lays in the periplasm.PMID: 16011798Integral Inner Membrane BBinout/inN/ACytoplasmicSRPSECyesyesN290.536SpI281.08238-110o6-25iUnknown215.99
SECD_ECOLIP0AG90
secD
b0408 JW0398 Protein-export membrane protein secDCell inner membrane Inner membrane (experimental). Integral inner membrane (experimental).PMID: 16079137 PMID: 15919657 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.158TMH01.57163-660i7-25o453-472i477-497o503-524i545-571o577-605iCytoplasmicMembrane1036.08
SECF_ECOLIP0AG93
secF
b0409 JW0399 Protein-export membrane protein secFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN30.112TMH02.24012-660i24-43o142-163i170-191o197-217i248-266o272-297iCytoplasmicMembrane10
YAHC_ECOLIP77219
yahC
b0317 JW0309 Uncharacterized protein yahCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN700.119TMH010.9451-45Yn4-15c23/24o33-49i61-80o86-104i109-127o133-152iCytoplasmicMembrane10
ESSQ_ECOLIP77237
essQ

ydfS

ydfSb1556 JW5255 Lysis protein S homolog from lambdoid prophage QinIntegral Inner Membrane BBinoutin/inIM (predicted)Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)yesnoN380.166CYT0-0.200913-21Yn7-15c20/21o36-58iUnknown217.06
YAFU_ECOLIP77354
yafU
b0218 JW0207 Putative inner membrane protein yafUIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECpseudogene (Uniprot)nonoN390.16TMH01.65262-220i21-38o44-64iCytoplasmicMembrane1073.08
SECE_ECOLIP0AG96
secE

prlG

prlGb3981 JW3944 Preprotein translocase subunit SecEIntegral inner membrane (experimental).Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN480.137TMH07.80526-330o16-36i43-61o95-119iCytoplasmicMembrane107.85
SECG_ECOLIP0AG99
secG
b3175 JW3142 Protein-export membrane protein SecG (P12) (Preprotein translocase band 1 subunit)Inner membrane (experimental). Integral inner membrane (experimental).PMID: 15919657 PMID: 15919996Integral Inner Membrane BBinoutin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN290.153TMH011.5638-21Yn4-22c27/28o51-70iCytoplasmicMembrane1049.35
SECY_ECOLIP0AGA2
secY

prlA

prlAb3300 JW3262 Preprotein translocase subunit SecYIntegral inner membrane (experimental). Integral Membrane ProteinPMID: 15919996 PMID: 3004955Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN470.104CYT0-0.200913-10100i23-44o75-98i119-139o154-174i186-203o215-237i274-296o316-337i373-391o397-418iCytoplasmicMembrane10
UHPT_ECOLIP0AGC0
uhpT
b3666 JW3641 Hexose phosphate transport proteinIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN530.105TMH00.582302-12120i28-45o65-85i97-117o123-148i160-183o189-210i260-278o298-318i327-345o351-380i392-411o423-446iCytoplasmicMembrane10
SMP_ECOLIP0AGC7
smp

ytjB

ytjBb4387 JW4350 Protein smpHas an aminoterminal stop transfer or signal sequence hydrophobic region and a second hydrophobic region near the C-terminus that may function as a stop transfer sequence; The protein was shown to fractionate with the bacterial membrane. No processing of tPMID: 2684780Integral Inner Membrane BBinoutin/outIM (predicted)Cell membrane | Peripheral membrane proteinMembrane anchoredSRPSECpseudogene (Ochman & Davalos, 2006)nonoN300.128SpI307.66045-11Yn13-24c29/30o164-184iCytoplasmicMembrane1063.29
HOKB_ECOLIP77494
hokB

ydcB

ydcBb4428 JW5225 Autoinducer 2 import system permease protein lsrC (AI-2 import system permease protein lsrC)Potentially toxic protein.PMID: 19121005Integral Inner Membrane BBinout/inN/AMembrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN260.105CYT0-0.200913-110o6-24iPeriplasmic9.9642.15
YBDJ_ECOLIP77506
ybdJ
b0580 JW0569 Uncharacterized protein ybdJIntegral Inner Membrane BBinoutin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN360.165TMH013.1416-21Yn7-25c33/34o49-70iCytoplasmicMembrane9.86
YAGL_ECOLIP77607
yagL
b0278 JW0272 Uncharacterized protein yagLIntegral Inner Membrane BBoutin/outIM (predicted)CytoplasmicSRPSECProphage Integrase (EcoGene)nonoN320.112CYT0-0.200913-010i12-32oCytoplasmic8.9613.93
SSTT_ECOLIP0AGE4
sstT

ygjU

ygjUb3089 JW3060 Serine/threonine transporter sstT (Na(+)/serine-threonine symporter)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.148TMH07.50816-880i18-36o42-72i84-106o149-166i187-209o215-240i290-315o327-352iCytoplasmicMembrane1015.42
XYLE_ECOLIP0AGF4
xylE
b4031 JW3991 D-xylose-proton symporter (D-xylose transporter)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN300.155TMH06.47202-1211Yn13-24c32/33o56-78i90-109o129-151i163-186o198-220i270-293o313-334i346-364o370-395i407-426o446-463iCytoplasmicMembrane10
YHHJ_ECOLIP0AGH1
yhhJ
b3485 JW5677 Inner membrane transport permease yhhJIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.231SpI401.57995-560i174-200o220-244i256-281o287-306i318-337o343-364iCytoplasmicMembrane106.97
SAPB_ECOLIP0AGH3
sapB
b1293 JW1286 Peptide transport system permease protein sapBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN280.197TMH016.0324-560i9-29o82-101i113-141o175-193i245-263o283-305iCytoplasmicMembrane109.44
SAPC_ECOLIP0AGH5
sapC
b1292 JW1285 Peptide transport system permease protein sapCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN510.132TMH05.59827-560i31-54o99-123i144-169o189-208i220-241o261-283iCytoplasmicMembrane1010.97
GTRA_ECOLIP77682
yfdG
b2350 JW2346 Bactoprenol-linked glucose translocase homolog from prophage CPS-53Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECProphage Integrase (EcoGene)nonoN380.341TMH011.761-440i12-30o36-55i67-85o91-110iCytoplasmicMembrane10
YAHH_ECOLIQ2EEQ3
yahH
b0322 JW5893 Putative uncharacterized protein yahHMembrane anchored by EchoLOCATIONIntegral Inner Membrane B-N/AMembrane anchoredSECpseudogene (Uniprot), pseudogene (Ecogene)nonoN420.264CYT0-0.200913-000iUnknown2
YNID_ECOLIQ2EES1
yniD
b4535 JW5911 Uncharacterized protein yniDSmall membrane protein detected experimentally.PMID: 19121005Integral Inner Membrane BBinoutin/outIM (predicted)Membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN310.1TMH04.22082-10Yn14-26c30/31oCytoplasmicMembrane9.82
PSTC_ECOLIP0AGH8
pstC

phoW

phoWb3727 JW3705 Phosphate transport system permease protein pstCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN30.109TMH04.7509-660i21-43o75-100i112-143o163-186i227-249o282-304iCytoplasmicMembrane10
RBSC_ECOLIP0AGI1
rbsC
b3750 JW3729 Ribose transport system permease protein rbsCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN580.121TMH06.39117-8100i23-43o49-68i75-93o99-119i126-144o170-190i221-240o252-270i275-292o298-316iCytoplasmicMembrane1018.02
XYLH_ECOLIP0AGI4
xylH
b3568 JW3540 Xylose transport system permease protein xylHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN510.13TMH04.89182-10110i25-45o65-83i90-107o113-132i139-156o176-196i217-235o241-259i290-306o326-357i369-385oCytoplasmicMembrane10
UBIA_ECOLIP0AGK1
ubiA

cyr

cyrb4040 JW4000 4-hydroxybenzoate octaprenyltransferase (EC 2.5.1.-) (4-HB polyprenyltransferase)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN360.118TMH06.00125-770i23-40o46-70i99-132o152-182i210-229o235-252i273-289oCytoplasmicMembrane10
YHHT_ECOLIP0AGM0
yhhT
b3474 JW5680 UPF0118 inner membrane protein yhhTIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.162TMH05.38885-880i12-31o37-55i62-87o133-163i197-215o221-246i253-275o295-315iCytoplasmicMembrane104.32
YOHO_ECOLIQ2EES6
yohO
b4542 JW5354 UPF0387 membrane protein yohOSmall membrane protein detected experimentally PMID: 19121005Integral Inner Membrane BBinoutout/inN/ACell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN260.149TMH04.51604-110o6-31iCytoplasmicMembrane9.82
YPFN_ECOLIQ2EET2
ypfN
b4547 JW2457 UPF0370 protein ypfNIntegral Inner Membrane BBinout/inIM (predicted)Cell membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN260.107CYT0-0.200913-110o6-24iUnknown271.1
YTJA_ECOLIQ2M5U1
ytjA
b4568 JW5891 UPF0391 membrane protein ytjAIntegral Inner Membrane BBinoutin/inN/ACell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.166TMH011.6664-21Yn4-14c19/20o29-49iCytoplasmicMembrane9.86
YOBH_ECOLIQ2MB16
yobH
b4536 JW5298 Uncharacterized protein yobHSignal peptide predicted, single transmembrane helice predicted which would be removed upon signal peptide cleavage. Putative outer membrane or exported. Taxonomy: Klebsiella pneumoniae.Integral Inner Membrane BBoutin/outN/AMembrane anchoredSRPSECnoyesN340.169TMH05.54741-10Yn10-20c24/25oCytoplasmicMembrane9.8257.93
YICG_ECOLIP0AGM2
yicG
b3646 JW3621 UPF0126 inner membrane protein yicGIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN220.368CYT0-0.200913-770o6-23i30-52o64-82i89-109o115-136i148-167o173-191iCytoplasmicMembrane10
URAA_ECOLIP0AGM7
uraA
b2497 JW2482 Uracil permease (Uracil transporter)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN470.107TMH03.93213-12130i20-38o44-60i67-83o89-108i120-147o159-176i183-202o225-250i262-281o301-319i331-354o366-384i391-409oCytoplasmicMembrane10
XANP_ECOLIP0AGM9
xanP

yicE

yicEb3654 JW3629 Xanthine permease XanPCell inner membrane Integral inner membrane (experimental).PMID: 16096267 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN660.123CYT0-0.200913-11110o36-58i70-89o128-146i158-181o193-212i219-240o260-280i350-372o378-396i408-427o439-458iCytoplasmicMembrane109.17
PROP_ECOLIP0C0L7
proP
b4111 JW4072 Proline/betaine transporter (Proline porter II) (PPII)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.105CYT0-0.200913-12120i41-59o65-86i98-116o122-146i167-186o198-217i257-278o298-318i327-346o352-376i388-411o417-438iCytoplasmicMembrane10
MSCS_ECOLIP0C0S1
mscS

yggB

yggBb2924 JW2891 Small-conductance mechanosensitive channel Integral inner membrane (experimental). Integral inner membrane (experimental). Inner membrane (experimental). Integral inner membrane (experimental). Integral inner membrane (experimental). Integral Membrane Protein Integral Membrane Protein Integral Membrane ProteinPMID: 11266632 PMID: 12446901 PMID: 16079137 PMID: 15919657 PMID: 15919996 PMID: 12446901 PMID: 12767977 PMID: 12015316 PMID: 10202137Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN520.15TMH0-0.184901-330o24-45i65-85o97-125iCytoplasmicMembrane1042.06
SIRB2_ECOLIQ46755
sirB2

ychQ

ychQb1213 JW1204 Protein sirB2Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN390.138TMH06.48818-440o6-28i40-61o73-93i105-123oCytoplasmicMembrane1025.14
YGFX_ECOLIQ46824
ygfX

ygfX

ygfXb2896 JW2864 Uncharacterized protein ygfXCell inner membranePMID: 22239607Integral Inner Membrane BBpolyin/inIM (predicted)Membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN390.141TMH05.61025-120i12-32o38-54iCytoplasmicMembrane9.8233.04
CPTA_ECOLIP0CB39
cptA

cptA yijP

cptA yijPb3955 JW3927 Phosphoethanolamine transferase CptA (EC 2.7.-.-)Cell inner membranePMID: 16079137Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN90.182TMH012.4414-550i20-39o45-63i70-91o120-139i151-169oCytoplasmicMembrane1026.69
UIDB_ECOLIP0CE44
uidB

gusB uidP

gusB uidPb1616 JW1608 Glucuronide carrier protein homologIntegral inner membrane (experimental). Integral Membrane ProteinPMID: 15919996 PMID: 15774881Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN610.197TMH05.96454-12120i12-35o41-60i81-101o113-136i148-170o182-201i230-257o263-284i296-316o322-343i376-393o405-427iCytoplasmicMembrane10
RCSC_ECOLIP0DMC5
rcsC
b2218 JW5917/JW5920 Sensor kinase protein RcsC (EC 2.7.13.3) (Capsular synthesis regulator component C)Cell inner membraneFusions of rcsC to phoA that resulted in PhoA+ strains demonstrated that RcsC is a transmembrane protein with a periplasmic N-terminal domain and cytoplasmic C-terminal domain.PMID: 15919996 PMID: 2404948Integral Inner Membrane BBinoutout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN360.159TMH03.16217-21Yn20-31c40/41o314-334iCytoplasmicMembrane10
YQGA_ECOLIQ46831
yqgA
b2966 JW2934 Uncharacterized protein yqgAIntegral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN200.108TMH03.98827-680o6-23i30-50o56-75i103-123o135-157i164-181o187-206i213-233oCytoplasmicMembrane10
YGHD_ECOLIQ46832
yghD
b2968 JW2935 Putative general secretion pathway protein M-type yghDIntegral Inner Membrane BBoutin/outIM (predicted)Cell inner membraneMembrane anchoredSRPSECnoyesN430.102CYT0-0.200913-110i38-57oUnknown228.25
YGHE_ECOLIQ46833
yghE
b2969 Putative general secretion pathway protein L-type yghEIntegral Inner Membrane BBinoutin/outIM (predicted)Cell inner membraneCytoplasmicSRPSECpseudogene (Uniprot) nonoN380.296CYT0-0.200913-110i136-159oUnknown2
YGHS_ECOLIQ46843
yghS
b2985 JW5491 Uncharacterized ATP-binding protein yghSIntegral Inner Membrane BBinoutin/outIM (predicted)CytoplasmicSRPSECnoyesN330.133CYT0-0.200913-010i161-178oCytoplasmic8.9635.57
NARK_ECOLIP10903
narK
b1223 JW1214 Nitrite extrusion protein 1 (Nitrite facilitator 1)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN600.17TMH00.305282-12120i38-62o74-92i104-124o130-158i178-197o217-234i255-278o290-308i320-339o351-377i404-425o437-457iCytoplasmicMembrane10
UGPA_ECOLIP10905
ugpA
b3452 JW3417 sn-glycerol-3-phosphate transport system permease protein ugpAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN390.107TMH013.7961-660i12-31o78-100i112-130o157-181i206-228o267-288iCytoplasmicMembrane10
UGPE_ECOLIP10906
ugpE
b3451 JW3416 sn-glycerol-3-phosphate transport system permease protein ugpEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN440.2TMH09.6685-670i7-31o81-105i112-133o145-166i187-210o216-238i250-272oCytoplasmicMembrane1028.1
NARI_ECOLIP11350
narI

chlI

chlIb1227 JW1218 Respiratory nitrate reductase 1 gamma chain (EC 1.7.99.4) (Cytochrome B-NR) (Nitrate reductase A subunit gamma) (Quinol-nitrate oxidoreductase subunit gamma) Integral inner membrane (experimental). Integral inner membrane (experimental). Integral Membrane ProteinUnder anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (nitrate reductase A; NarGHI) PMID: 12910261. Part of the nitrate reductase A (NarGHI) of Escherichia coli which is membrane anchored through the NarI subunit. NarH is the electron transfer subunit. PMID: 12910261 In vivo associations of Escherichia coli NarJ with a peptide of the first 50 residues of nitrate reductase catalytic subunit NarG. PMID: 19295650 When E. coli is grown anaerobically in the presence of high levels of nitrate, the respiratory chain that is formed is terminated by NarGHI otherwise known as the quinol nitrate oxidoreductase. PMID: 2674654 The heterotrimeric NarGHI has an αβγ structure encoded by narGHI respectively. The α and β subunits can be purified as a soluble NarGH dimer in the cytoplasm showing that these 2 subunits associate to form a stable subcomplex before association with the membrane γ subunit. PMID: 3371362 PMID: 3053688PMID: 11266632 PMID: 12910261 PMID: 15919996 PMID: 19295650 PMID: 2674654 PMID: 3371362 PMID: 3053688Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN190.113TMH011.8819-550o6-26i47-69o89-109i129-148o179-198iCytoplasmicMembrane10
YGHT_ECOLIQ46844
yghT
b2986 JW2954 Uncharacterized ATP-binding protein yghTIntegral Inner Membrane BBinout/inIM (predicted)CytoplasmicSRPSECnoyesN360.139CYT0-0.200913-010o77-95iCytoplasmic8.9650.11
YGIZ_ECOLIQ46867
ygiZ
b3027 JW2995 Inner membrane protein ygiZIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.138TMH04.05338-330i12-29o54-72i84-103oCytoplasmicMembrane1027.07
YQEJ_ECOLIQ46943
yqeJ
b2848 JW5455 Uncharacterized protein yfbKIntegral Inner Membrane BBoutin/outN/AMembrane | Single-pass membrane proteinPeriplasmicSRPSECnoyesN280.216SpI276.43067-110i7-27oUnknown2
FUCP_ECOLIP11551
fucP
b2801 JW2772 Uncharacterized protein yjeVIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN420.298TMH00.0692344-12120i21-41o61-85i92-111o117-134i155-177o210-228i262-282o294-315i327-345o351-373i385-405o411-431iCytoplasmicMembrane10
DAMX_ECOLIP11557
damX

yhfB

yhfBb3388 JW3351 Protein damXSeptal ring. Septal ring protein. Peripheral inner membrane protein facing the cytoplasm (experimental). Contain a SPOR Domain. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338PMID: 23290046 PMID: 19880599 PMID: 21541338Integral Inner Membrane BBinoutin/outIM (predicted), Detected in IM FractionCell membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN680.101CYT0-0.200913-110i103-124oUnknown2
ARGO_ECOLIP11667
argO

yggA

yggAb2923 JW2890 Arginine exporter protein ArgOIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein(experimental)SRPSECyesyesN250.273TMH06.65864-660o6-26i38-61o67-88i109-127o147-170i182-199oCytoplasmicMembrane1018.85
CSRD_ECOLIP13518
csrD

yhdA

yhdAb3252 JW3221 RNase E specificity factor CsrD (Regulator of CsrB and CsrC decay CsrD)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.172TMH05.84825-220i7-31o130-155iCytoplasmicMembrane9.824.27
YQJK_ECOLIQ47710
yqjK
b3100 JW3071 Uncharacterized protein yqjKIntegral Inner Membrane BBinoutin/outIM (predicted), Detected in IM FractionMembrane anchoredSRPSECyesyesN620.14CYT0-0.200913-110i47-65oUnknown230.6
LDRD_ECOLIQ6BF25
ldrD
b4453 JW5966 Small toxic polypeptide ldrDPotentially toxic protein.PMID: 19121005Integral Inner Membrane BBinoutout/inIM (predicted)CytoplasmicSRPSECyesyesN210.155CYT0-0.200913-110o14-31iCytoplasmicMembrane9.82
LDRA_ECOLIQ6BF86
ldrA

ldrC

ldrCb4419 JW5957Small toxic polypeptide ldrA/ldrCPotentially toxic protein.PMID: 19121005Integral Inner Membrane BBinoutout/inIM (predicted)CytoplasmicSRPSECyesyesN210.125CYT0-0.200913-110o6-31iCytoplasmicMembrane9.82
LDRB_ECOLIQ6BF87
ldrB
b4421 JW5958 Small toxic polypeptide ldrBPotentially toxic protein.PMID: 19121005Integral Inner Membrane BBinoutout/inIM (predicted)CytoplasmicSRPSECyesyesN210.121CYT0-0.200913-110o14-31iCytoplasmicMembrane9.82
YMGG_ECOLIQ7DFV3
ymgG
b1172 JW5178 UPF0757 protein ymgGBelongs to the UPF0757 family. PMID: 18192383 PMID: 17787032Integral Inner Membrane BBpolyin/inN/AMembrane anchoredSRPSECnoyesY230.871SpI2223.9513-20Yn5-16c22/23oUnknown2.598.94
NHAA_ECOLIP13738
nhaA

ant

antb0019 JW0018 Na(+)/H(+) antiporter nhaA (Sodium/proton antiporter nhaA) Integral inner membrane (experimental). Integral inner membrane (experimental).Structure of a Na+/H+ antiporter. A negatively charged ion funnel opens to the cytoplasm and ends in the middle of the membrane at the putative ion-binding site PMID: 15988517.PMID: 11266632 PMID: 15988517 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN340.227TMH07.93195-11110i12-39o59-79i91-114o126-145i154-175o181-200i207-238o258-276i288-312o324-351i363-380oCytoplasmicMembrane10
PROW_ECOLIP14176
proW
b2678 JW2653 Glycine betaine/L-proline transport system permease protein proWIntegral inner membrane (experimental).PMID: 10949305 PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN240.12CYT0-0.200913-660o97-118i125-143o149-171i192-219o271-291i303-320oCytoplasmicMembrane105.07
ZRAS_ECOLIP14377
zraS

hydH

hydHb4003 JW3967 Sensor protein zraS (EC 2.7.13.3)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN440.129TMH07.59471-220i12-35o202-222iCytoplasmicMembrane10
FECD_ECOLIP15029
fecD
b4288 JW4248 Fe(3+) dicitrate transport system permease protein fecD (Iron(III) dicitrate transport system permease protein fecD)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN280.121TMH010.0321-77Yn4-19c31/32o55-76i85-103o109-126i138-158o226-256i268-290o296-315iCytoplasmicMembrane104.14
FECC_ECOLIP15030
fecC
b4289 JW4249 Fe(3+) dicitrate transport system permease protein fecC (Iron(III) dicitrate transport system permease protein fecC)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.15TMH07.31223-89Yn8-27c36/37o60-81i93-111o117-140i152-171o177-194i201-220o240-270i282-304o310-328iCytoplasmicMembrane10
CSTA_ECOLIP15078
cstA

ybdC

ybdCb0598 JW0590 Uncharacterized protein yjcFIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN210.185TMH08.48745-18160i7-26o32-52i93-111o117-138i159-185o191-209i221-240o260-277i284-305o325-345i373-393o470-494i515-534o546-571i578-598o648-671iCytoplasmicMembrane10
FLK_ECOLIP15286
flk

div

divb2321 JW2318 Flagellar regulator flkIntegral Inner Membrane BBoutout/inIM (predicted)Cell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN540.104CYT0-0.200913-110o313-330iCytoplasmicMembrane9.8261.56
DHG_ECOLIP15877
gcd
b0124 JW0120 Quinoprotein glucose dehydrogenase (EC 1.1.5.2) (Glucose dehydrogenase [pyrroloquinoline-quinone])Cell inner membrane, Periplasmic side Integral inner membrane (experimental). Cell inner membrane, Periplasmic side Integral Membrane Protein Integral Membrane Protein Integral Membrane ProteinPMID: 16079137 PMID: 15919996 PMID: 8509415 PMID: 8419307 PMID: 8554505Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane protein | Periplasmic sideIntegral Membrane Protein (Experimental)SRPSECyesyesN430.121TMH021.0845-550i12-35o41-58i65-81o87-106i113-140oCytoplasmicMembrane9.8618.68
AROP_ECOLIP15993
aroP
b0112 JW0108 Aromatic amino acid transport protein AroP (General aromatic amino acid permease)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN440.121TMH09.5384-12120i20-41o47-63i84-105o125-142i154-176o196-220i241-263o283-300i332-353o359-379i400-422o428-446iCytoplasmicMembrane10
PANF_ECOLIP16256
panF
b3258 JW3226 Sodium/pantothenate symporter (Pantothenate permease)Integral inner membrane (experimental).Prediction of one very weak transmembrane region.PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN240.187TMH08.73514-13130o6-24i45-63o75-94i122-144o156-178i190-213o233-253i273-298o318-341i369-386o392-417i424-442o448-466iCytoplasmicMembrane10
HYCC_ECOLIP16429
hycC

hevC

hevCb2723 JW2693 Formate hydrogenlyase subunit 3 (FHL subunit 3) (Hydrogenase-3 component C)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.168TMH011.9962-14160o6-26i33-58o78-96i108-124o130-146i153-173o197-218i230-251o257-280i292-312o332-349i370-395o415-435i456-480o500-521i587-605oCytoplasmicMembrane10
HYCD_ECOLIP16430
hycD

hevD

hevDb2722 JW2692 Formate hydrogenlyase subunit 4 (FHL subunit 4) (Hydrogenase 3 component D)Integral inner membrane (experimental).PMID: 1625581 PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN300.198CYT0-0.200913-880o6-27i62-85o97-119i131-149o169-188i224-242o248-273i285-306oCytoplasmicMembrane10
PHNE_ECOLIP16683
phnE
b4104 JW4065 b4103Putative phosphonates transport system permease protein phnECell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)noyesN360.143TMH08.60214-660i12-33o75-99i120-143o179-197i206-224o230-250iCytoplasmicMembrane107.9
CYST_ECOLIP16701
cysU

cysT

cysTb2424 JW2417 Sulfate transport system permease protein cysTIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN370.285TMH014.8684-750o12-37i58-84o104-125i137-156o242-263iCytoplasmicMembrane10117.73
MREC_ECOLIP16926
mreC
b3250 JW3219 Rod shape-determining protein mreCCell inner membranePMID: 15612918Integral Inner Membrane BBoutin/outIM (predicted), Detected in IM FractionMembrane anchoredSRPSECnoyesN250.114TMH02.1577-10Yn15-23c28/29oUnknown235.38
PTQC_ECOLIP17334
chbC

celB

celBb1737 JW1726 N,N'-diacetylchitobiose permease IIC component (EIIC-Chb) (PTS system N,N'-diacetylchitobiose-specific EIIC component)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN280.124CYT0-0.200913-10100i35-55o86-107i114-133o145-167i187-207o235-258i301-320o332-352i359-384o404-429iCytoplasmicMembrane105.27
CYNX_ECOLIP17583
cynX
b0341 JW0332 Cyanate transport protein cynXCell inner membraneExhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCnoyesN550.147CYT0-0.200913-1211Yn2-10c18/19o34-55i67-85o91-113i125-147o153-173i201-224o230-251i263-281o287-309i321-339o354-372iCytoplasmicMembrane10
PGPA_ECOLIP18200
pgpA

yajN

yajNb0418 JW0408 Phosphatidylglycerophosphatase A (EC 3.1.3.27)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN450.137TMH013.1049-350i21-51o57-75i87-104o110-126i138-162oCytoplasmicMembrane1023
RSTB_ECOLIP18392
rstB

uspT

uspTb1609 JW1601 Sensor protein rstB (EC 2.7.13.3)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN320.112TMH02.20306-220o6-27i136-157oCytoplasmicMembrane1053.8
DMSC_ECOLIP18777
dmsC
b0896 JW0879 Anaerobic dimethyl sulfoxide reductase chain C (DMSO reductase anchor subunit)Integral inner membrane (experimental). Integral inner membrane. Peripheral inner membrane protein facing the cytoplasm or the periplasm. DMSO reductase subunit C,Periplasmic. Has a membrane bound anchor. Part of the anaerobic dimethylsulphoxide (DMSO) reductase DmsABC. The DmsC polypeptide is composed of eight segments of hydrophobic amino acids of appropriate length to cross the cytoplasmic membrane, suggesting that this subunit functions to anchor the DMSO enzyme to the membrane. PMID: 3062312 There are contradictory experiments although it seems that the senario of the DmsABC complex facing the cytoplasm is more favoured. PMID: 11389150 The localization of DmsAB was compared in a strain expressing a partial DmsC subunit (pDMSC59X) with full-length DmsC originating from the chromosomal copy of the dms operon. In those experiments some DmsAB was reported in the periplasm in the absence of full-length DmsC, leading us to suggest that DmsC might serve a stop-transfer role. PMID: 9546395 TnphoA fusions, and electron paramagnetic resonance monitoring the effects of the probe dysprosium(III) on an engineered 3Fe4S cluster in DmsB indicated that DmsAB faces the cytoplasm PMID: 2170332 PMID: 15919996PMID: 15919996 PMID: 3062312 PMID: 11389150 PMID: 9546395 PMID: 2170332Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN220.177TMH013.558-880o12-32i44-68o88-105i117-137o149-171i183-203o223-243i255-277oCytoplasmicMembrane10
PTOCB_ECOLIP19642
malX
b1621 JW1613 PTS system maltose- and glucose-specific EIICB component [Includes: Maltose and glucose permease IIC component (PTS system maltose- and glucose-specific EIIC component); Maltose- and glucose-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN440.116TMH07.8693-8100i21-42o62-89i96-116o136-161i182-205o295-313i320-337o343-362i369-391o397-419iCytoplasmicMembrane105.71
TOLA_ECOLIP19934
tolA

cim excC lky

cim excC lkyb0739 JW0729 Protein tolAInner membrane (experimental). Membrane anchored The N-terminal coiled coil of YbgFvforms a stable trimer and controls the oligomeric status of YbgF. The stable YbgF trimer undergoes a marked change in oligomeric state on binding TolA, forming a one-to-one complex with the Tol protein. PMID: 7744737 Disulfide bridge (363 388) Disulfide bond-containing protein PMID: 25664544PMID: 15919657 PMID: 20816983 PMID: 7744737 PMID: 25664544Integral Inner Membrane BBoutin/outIM (predicted)Cell inner membrane | Single-pass type II membrane proteinMembrane anchored (Experimental)SRPSECyesyesN430.131CYT0-0.200913-110i12-31oUnknown250.77
PTFBC_ECOLIP20966
fruA

ptsF

ptsFb2167 JW2154 PTS system fructose-specific EIIBC component (EIIBC-Fru) [Includes: Fructose-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (EIII-Fru) (PTS system fructose-specific EIIB component); Fructose permease IIC component (PTS system fructose-specIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.169CYT0-0.200913-990i230-256o268-291i303-329o349-368i389-410o430-451i463-482o488-507i519-551oCytoplasmicMembrane107.17
GLTP_ECOLIP21345
gltP
b4077 JW4038 Proton glutamate symport protein (Glutamate-aspartate carrier protein)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.123TMH011.2813-10100i7-27o47-72i84-106o160-181i202-224o236-264i293-311o323-350i362-385o391-409iCytoplasmicMembrane1019.34
YCIC_ECOLIP21365
yciC
b1255 JW1247 UPF0259 membrane protein yciCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN470.196TMH06.50025-660i20-41o77-104i116-136o142-166i187-212o218-239iCytoplasmicMembrane10
YCAD_ECOLIP21503
ycaD
b0898 JW0881 Uncharacterized MFS-type transporter ycaDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.154TMH014.4924-1211Yn10-18c23/24o47-65i74-92o98-119i131-149o161-181i202-223o235-253i265-283o289-311i323-345o351-369iCytoplasmicMembrane10
KDPD_ECOLIP21865
kdpD
b0695 JW0683 Sensor protein kdpD (EC 2.7.13.3)Cell inner membrane Integral inner membrane (experimental).PMID: 1532388 PMID: 21605551 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN460.149CYT0-0.200913-440i399-419o425-443i448-465o477-498iCytoplasmicMembrane1022.58
RECJ_ECOLIP21893
recJ
b2892 JW2860 Single-stranded-DNA-specific exonuclease recJ (EC 3.1.-.-)Integral Inner Membrane BBinoutin/outIM (predicted)CytoplasmicSRPSECyesyesN390.112CYT0-0.200913-010i188-206oCytoplasmic9.97
LIVM_ECOLIP22729
livM
b3456 JW3421 High-affinity branched-chain amino acid transport system permease protein livM (LIV-I protein M)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.39SpI2011.5293-1010Yn9-20c25/26o44-61i91-108o114-132i137-156o162-184i191-209o262-283i313-336o348-373i385-403oCytoplasmicMembrane10
TNAB_ECOLIP23173
tnaB

trpP

trpPb3709 JW5619/JW5622 Low affinity tryptophan permeaseIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN250.14TMH016.6914-11110i12-32o38-61i82-105o125-143i155-174o194-219i226-246o282-310i322-341o347-369i381-406oCytoplasmicMembrane105.98
MGLC_ECOLIP23200
mglC
b2148 JW2135 Galactoside transport system permease protein mglCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.106TMH05.37465-980i12-31o43-64i105-129o135-155i175-201o227-248i269-299o311-330iCytoplasmicMembrane10
HYFB_ECOLIP23482
hyfB

yffF

yffFb2482 JW2467 Hydrogenase-4 component B (EC 1.-.-.-)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN570.166TMH07.57984-16160o6-27i39-62o82-103i110-129o135-154i166-185o205-224i245-267o273-296i303-326o332-363i383-405o425-452i473-496o532-551i652-671oCytoplasmicMembrane10
FECR_ECOLIP23485
fecR
b4292 JW4252 Protein fecRInner membraneThe protein is oriented such that residues 1 to 85 are in the cytoplasm, residues 86 to 100 form a transmembrane segment, and residues 101 to 317 are in the periplasm where the C-terminus can interact with the N-domain of the outer membrane protein FecA.PMID: 9573190 PMID: 12057967Integral Inner Membrane B-IM (predicted-detected)PeriplasmIntegral Membrane ProteinSRPSECnoyesN350.136CYT0-0.200913-000iPeriplasmic10
PHOQ_ECOLIP23837
phoQ
b1129 JW1115 Sensor protein phoQ (EC 2.7.13.3)Integral inner membrane (experimental). Sensor protein PhoQ (P23837) PMID: 23359663 PMID: 15919996 Integral Inner Membrane BBinout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN230.287TMH06.14229-21Yn17-28c33/34o194-216iCytoplasmicMembrane1020.04
YFEA_ECOLIP23842
yfeA
b2395 JW5391 Uncharacterized protein YfeAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Integral Membrane ProteinSRPSECnoyesN450.113TMH09.46751-890o12-31i43-61o81-104i125-143o163-186i214-232o238-255i262-279o291-312iCytoplasmicMembrane10
TRKG_ECOLIP23849
trkG
b1363 JW1358 Trk system potassium uptake protein trkGIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)PeriplasmIntegral Membrane ProteinSRPSECProphage Integrase (EcoGene)yesnoN320.135TMH011.2875-11110i12-34o40-60i72-93o139-164i185-206o239-263i275-296o336-356i399-418o424-446i458-483oCytoplasmicMembrane10
FEPD_ECOLIP23876
fepD
b0590 JW0582 Ferric enterobactin transport system permease protein fepDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN510.205TMH01.30983-990o6-30i64-81o93-114i121-139o151-172i193-213o239-264i284-304o310-326iCytoplasmicMembrane10
FEPG_ECOLIP23877
fepG
b0589 JW0581 Ferric enterobactin transport system permease protein fepGIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN230.416TMH010.9363-88Yn8-23c41/42o65-83i95-112o118-138i145-167o187-211i236-262o274-296i303-324oCytoplasmicMembrane10
CYDC_ECOLIP23886
cydC

mdrA mdrH surB

mdrA mdrH surBb0886 JW0869 ATP-binding/permease protein cydCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN500.199TMH016.2776-660i16-35o41-61i133-155o161-182i243-266o278-301iCytoplasmicMembrane1010.22
CADC_ECOLIP23890
cadC
b4133 JW4094 Transcriptional activator CadCNucleoid (experimental). Inner membrane. Integral inner membrane. Inner membrane.Membrane-integrated pH sensor. The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP.PMID: 23138451 PMID: 24056175 PMID: 21890895 PMID: 18086202Nucleoid, Integral Inner Membrane N, BIM (predicted)Cell membrane | Single-pass membrane protein.Membrane anchoredSRPSECnoyesN500.131CYT0-0.200913-110o159-181iCytoplasmicMembrane9.82
HTPX_ECOLIP23894
htpX
b1829 JW1818 Protease HtpX (EC 3.4.24.-) (Heat shock protein HtpX)Cell inner membrane Integral inner membrane (experimental).PMID: 12081643 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.141TMH012.8648-43Yn4-18c23/24o33-53i158-178o193-217iCytoplasmicMembrane108.21
EMRE_ECOLIP23895
emrE

eb mvrC

eb mvrCb0543 JW0531 Multidrug transporter emrE (Efflux-multidrug resistance protein emrE) (Ethidium resistance protein) (Methyl viologen resistance protein C)Integral inner membrane (experimental). Exhibites aberrant localization by microscopy in the absence of YidC. Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996PMID: 22108384 PMID: 15919996 PMID: 24688744 PMID: 22178925 PMID: 16429150 PMID: 20508091 PMID: 22444835Integral Inner Membrane BBpoly, Bmultiin/out, out/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPYidCProphage Integrase (EcoGene), pseudogene (Ochman & Davalos, 2006)nonoN620.162TMH06.32256-430o30-48i60-79o85-104iCytoplasmicMembrane107.14
ARAJ_ECOLIP23910
araJ
b0396 JW0386 Protein AraJIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.21TMH04.92502-1211Yn4-15c20/21o44-63i70-96o102-120i127-150o156-178i199-219o225-251i263-284o290-310i331-350o356-375iCytoplasmicMembrane10
LNT_ECOLIP23930
lnt

cutE

cutEb0657 JW0654 Apolipoprotein N-acyltransferase (ALP N-acyltransferase) (EC 2.3.1.-) (Copper homeostasis protein cutE)Cell inner membrane Cell inner membranePMID: 2032623 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN280.184TMH013.3696-680i12-28o34-50i57-79o91-112i124-142o162-188i195-214o489-507iCytoplasmicMembrane102.91
ENTS_ECOLIP24077
entS

ybdA

ybdAb0591 JW0583 Enterobactin exporter entS (Protein p43)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.337TMH010.2914-11120i21-42o54-74i86-105o111-135i147-170o176-199i219-246o258-276i288-305o311-336i357-374o380-399iCytoplasmicMembrane10
ACRD_ECOLIP24177
acrD

yffA

yffAb2470 JW2454 Probable aminoglycoside efflux pump (Acriflavine resistance protein D)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN350.15SpI345.86063-1111Yn10-21c26/27o340-359i366-387o393-413i438-458o470-497i538-558o873-890i897-917o923-944i972-992o1004-1026iCytoplasmicMembrane10
ACRF_ECOLIP24181
acrF

envD

envDb3266 JW3234 Acriflavine resistance protein F (Protein envD)Cell inner membrane Integral inner membrane (experimental).PMID: 11274125 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.286SpI2612.2125-1211Yn10-21c26/27o340-359i366-390o396-416i437-458o470-497i541-558o872-891i898-918o924-948i969-990o1002-1028iCytoplasmicMembrane10
MSBB_ECOLIP24205
msbB
b1855 JW1844 Lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase (EC 2.3.1.-)Integral Inner Membrane BBinout/inIM (predicted)Cell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN450.121CYT0-0.200913-110o24-43iCytoplasmicMembrane1016.98
PHEP_ECOLIP24207
pheP
b0576 JW0565 Phenylalanine-specific permeaseIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN530.106TMH01.83401-12120i30-49o55-71i107-130o136-156i163-184o204-228i249-271o291-308i340-361o367-387i408-428o434-452iCytoplasmicMembrane10
PTIBC_ECOLIP24241
ascF
b2715 JW5435 PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component (EIIBC-Asc) (EII-Asc) [Includes: Arbutin-, cellobiose-, and salicin-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system arbutin-, cellobiose-, and salicin-specifIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCnoyesN250.128CYT0-0.200913-8100i104-127o147-167i179-197o217-234i254-282o288-309i330-350o362-382i389-413o433-456iCytoplasmicMembrane107
TEHA_ECOLIP25396
tehA
b1429 JW1425 Tellurite resistance protein tehAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.119TMH012.0389-8100i12-31o43-64i76-97o103-121i141-160o166-184i196-218o230-249i256-274o286-310iCytoplasmicMembrane10
GABP_ECOLIP25527
gabP
b2663 JW2638 GABA permease (4-amino butyrate transport carrier) (Gamma-aminobutyrate permease)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.302TMH08.50646-12120i21-40o46-66i97-118o124-144i156-180o200-220i241-264o284-308i335-354o360-380i401-423o429-449iCytoplasmicMembrane10
YIDC_ECOLIP25714
yidC
b3705 JW3683 Inner membrane protein oxaACell inner membrane Cell inner membrane Inner membrane (experimental).YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase. The first periplasmic region of YidC include residues 24−346. Residues 215−265 of YidC are sufficient for SecF binding. The interaction of YidC with SecF is though not critical for cell viability as YidC, lacking residues 24-264, was fully functional to support the growth of E. coli. The integration of YidC into the cytoplasmic membrane requires the signal recognition particle, SecA and SecYEG.PMID: 10675323 PMID: 17073462 PMID: 11777926 PMID: 11821429 PMID: 16079137 PMID: 15919657Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN250.321SpI2412.0898-44Yn7-17c24/25o354-373i417-440o464-482i494-519oCytoplasmicMembrane1026.63
LYSP_ECOLIP25737
lysP

cadR

cadRb2156 JW2143 Lysine-specific permeaseIntegral inner membrane (experimental). Integral inner membrane (experimental). Integral inner membrane (experimental). Lysine-specific permease LysP and the membrane-integrated pH sensor CadC induce lysine-dependent adaptation of E. coli under acidic stress. In absence of lysine or high low pH LysP and CadC form stable complex. Probably CadC is inhibited by LysP via intramembrane and periplasmic contacts under non-inducing conditions. The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP.PMID: 15919996 PMID: 24056175 PMID: 18086202Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN470.175TMH010.7386-12120i21-43o49-66i103-125o131-149i161-182o202-224i245-267o287-312i348-365o371-394i415-435o447-467iCytoplasmicMembrane10
YCHE_ECOLIP25743
ychE
b1242 JW1229 UPF0056 membrane protein yhcEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.169TMH010.9574-660o12-32i52-72o78-97i118-141o147-168i189-210oCytoplasmicMembrane1013
MDTG_ECOLIP25744
mdtG

yceE

yceEb1053 JW1040 Multidrug resistance protein mdtGIntegral Membrane ProteinPMID: 11566977Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein(experimental)SRPSECnoyesN320.145TMH016.0858-10100i16-40o52-74i86-104o110-130i142-162o174-193i220-245o257-278i290-308o374-393iCytoplasmicMembrane10
YEIB_ECOLIP25747
yeiB
b2152 JW2139 Uncharacterized protein yeiBIntegral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.167TMH09.38597-10100i9-28o48-71i83-101o107-122i134-153o201-221i233-254o274-292i312-332o338-359iCytoplasmicMembrane10
FLIF_ECOLIP25798
fliF

fla AII.1 fla BI

fla AII.1 fla BIb1938 JW1922 Flagellar M-ring proteinCell inner membrane, Bacterial flagellum basal bodyPMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinBacterial flagellum basal bodyIntegral Membrane ProteinflagellumSRPSECnoyesN460.141SpI433.78777-220i23-43o451-468iCytoplasmicMembrane1054.53
LEP4_ECOLIP25960
gspO

hofD hopD hopO yheC

hofD hopD hopO yheCb3335 JW3297 Type 4 prepilin-like proteins leader peptide-processing enzyme [Includes: Leader peptidase (EC 3.4.23.43) (Prepilin peptidase); N-methyltransferase (EC 2.1.1.-)]Integral inner membrane (experimental).Part of gsp locus. PMID: 15919996PMID: 11118204 PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN240.153TMH00.982152-75Yn4-15c21/22o55-84i104-122o128-149i161-191o203-222iCytoplasmicMembrane10
FEPE_ECOLIP26266
fepE
b0587 JW0579 Ferric enterobactin transport protein fepEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN460.11CYT0-0.200913-220i42-61o339-362iCytoplasmicMembrane1033.53
APPB_ECOLIP26458
appB

cbdB cyxB

cbdB cyxBb0979 JW0961 Cytochrome bd-II oxidase subunit 2 (EC 1.10.3.-) (Cytochrome bd-II oxidase subunit II)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.107TMH010.1949-890o12-40i61-79o85-103i123-148o168-188i209-233o263-283i290-314o334-356iCytoplasmicMembrane10
APPC_ECOLIP26459
appC

cbdA cyxA

cbdA cyxAb0978 JW0960 Cytochrome bd-II oxidase subunit 1 (EC 1.10.3.-) (Cytochrome bd-II oxidase subunit I)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN370.11TMH011.9815-990o20-42i54-71o91-116i128-145o184-208i215-235o386-409i421-442o471-492iCytoplasmicMembrane10
PLSC_ECOLIP26647
plsC

parF

parFb3018 JW2986 1-acyl-sn-glycerol-3-phosphate acyltransferase (1-AGP acyltransferase) (1-AGPAT) (EC 2.3.1.51) (EC 2.3.1.n4) (Lysophosphatidic acid acyltransferase) (LPAAT) (Phosphatidic acid synthase) (PA synthase)Integral Inner MembranePMID: 1557036Integral Inner Membrane BBoutin/outIM (predicted)Cell inner membrane | Peripheral membrane proteinMembrane anchored (Experimental)SECyesyesN360.111TMH01.55803-110o6-27iCytoplasmicMembrane1028.89
RHAT_ECOLIP27125
rhaT
b3907 JW3878 L-rhamnose-proton symporter (L-rhamnose-H(+) transport protein)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted) , Soluble IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN200.227TMH012.7916-10100o6-26i38-58o64-85i97-121o133-154i175-194o214-234i255-277o289-310i322-343oCytoplasmicMembrane10
RFAL_ECOLIP27243
rfaL

waaL

waaLb3622 JW3597 O-antigen ligaseIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN370.114TMH00.404949-12120i20-38o44-60i72-91o103-122i134-152o172-189i196-212o218-233i240-258o349-368i375-393o399-415iCytoplasmicMembrane10
LPXK_ECOLIP27300
lpxK

ycaH

ycaHb0915 JW0898 Tetraacyldisaccharide 4'-kinase (EC 2.7.1.130) (Lipid A 4'-kinase)Integral Inner Membrane BBinout/inIM (predicted)Integral Membrane ProteinSRPSECnoyesN440.107TMH01.00613-110o12-34iUnknown230.93
EMRA_ECOLIP27303
emrA
b2685 JW2660 Multidrug resistance protein AIntegral inner membrane Integral inner membrane, periplasmic side.PMID: 1409590 PMID: 12482849Integral Inner Membrane BBoutin/outSoluble IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN380.157TMH06.79297-110i23-44oCytoplasmicMembrane1025.62
RODZ_ECOLIP27434
rodZ

yfgA

yfgAb2516 JW2500 Cytoskeleton protein rodZNucleoid (experimental). Inner Membrane; Cytoskeleton. Integral inner membrane. Cytoskeleton. Integral inner membrane. Inner membrane (experimental). Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. Quantitative immunoblotting agaist RodZ purified protein indicate that RodZ is present at ~650 copies per average exponentially growing cell in LB medium and M9. The hth domain of RodZ is not required for transcription but for interaction with MreB. The protein, RodZ, is required for assembly of the actin cytoskeleton MreB that controls cell wall synthesis and cell shape. PMID: 19194484PMID: 23138451 PMID: 9008159 PMID: 19078962 PMID: 21890895 PMID: 19008860 PMID: 15919657 PMCID: PMC2637328 PMID: 19194484Nucleoid, Integral Inner Membrane N, BIM (predicted)Cell inner membrane | Single-pass type II membrane proteinMembrane anchoredSECyesyesN350.243CYT0-0.200913-110i112-133oUnknown2
WZYE_ECOLIP27835
wzyE

wzy

wzyb3793 JW3769 Putative ECA polymeraseIntegral Membrane ProteinPMID: 16816184Integral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN220.116TMH014.4283-11110o6-26i38-58o70-88i115-137o157-175i182-199o205-220i227-245o337-361i381-398o410-430iCytoplasmicMembrane10
YIFK_ECOLIP27837
yifK
b3795 JW5595 Probable transport protein yifKIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.143TMH08.10925-12120i12-34o40-60i94-119o125-146i158-177o197-219i240-259o271-299i333-353o359-380i401-423o429-448iCytoplasmicMembrane1031.41
RARD_ECOLIP27844
rarD
b3819 JW5589 Protein rarDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.239TMH09.7991-10100i12-31o43-61i73-92o104-121i128-145o151-167i179-198o210-230i242-261o273-290iCytoplasmicMembrane10
NARQ_ECOLIP27896
narQ
b2469 JW2453 Nitrate/nitrite sensor protein narQ (EC 2.7.13.3)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.145TMH01.10259-220o14-34i147-169oCytoplasmicMembrane107.19
BCR_ECOLIP28246
bcr

bicA bicR sur suxA

bicA bicR sur suxAb2182 JW5363 Bicyclomycin resistance protein (Sulfonamide resistance protein)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN330.128TMH013.9575-12120i7-26o46-65i77-96o102-123i135-159o165-185i215-241o253-273i285-307o313-332i344-366o372-391iCytoplasmicMembrane10
ASMA_ECOLIP28249
asmA

yegA

yegAb2064 JW2049 Protein AsmAInner membrane Outer membrane Periplasm, Outer membrane Involved in outer memebrane protein assembly and has an apparent signal peptide. It has been predicted to be periplasmic or outer membrane protein but detailed sub-fractionation studies revealed that itIs localized to the inner membrane. Reduced LPS levels in asmA mutants indicate a possible role of AsmA in LPS biogenesis.PMID: 8866482 PMID: 19346309 PMID: 7476172 PMCID: PMC178309Integral Inner Membrane BBoutin/outN/APeriplasmMembrane anchoredSRPSECyesyesN260.141TMH010.2137-10Yn4-16c21/22oUnknown2.569.6
DINF_ECOLIP28303
dinF
b4044 JW4004 DNA-damage-inducible protein FCell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.258TMH03.41253-13130o6-22i29-49o61-83i103-124o152-173i180-199o205-227i259-278o284-302i338-359o371-393i405-422o428-446iCytoplasmicMembrane1010.07
YCEG_ECOLIP28306
yceG
b1097 JW1083 UPF0755 protein yceGIntegral Inner Membrane BBoutin/outN/AMembrane anchoredSRPSECyesyesN200.198SpI180.538854-10Yn4-15c20/21oUnknown6.4916.78
CYDD_ECOLIP29018
cydD

htrD

htrDb0887 JW0870 ATP-binding/permease protein cydDInner membrane (experimental). Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919657 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN430.111TMH00.800558-560i29-49o61-82i140-159o165-188i245-272o278-297iCytoplasmicMembrane10
FTSN_ECOLIP29131
ftsN

msgA

msgAb3933 JW3904 Cell division protein ftsNIntegral inner membrane. Integral inner membrane.Localizes to potential division sites in filamentous cells. FtsN interacts directly with itself, FtsW, FtsI and ZapA.PMID: 11703663 PMID: 20497333Integral Inner Membrane BBoutin/outSoluble IM FractionCell inner membrane | Single-pass type II membrane proteinMembrane anchoredSRPSECyesyesN410.126SpI400.332384-110i29-54oCytoplasmicMembrane1023.63
THIF_ECOLIP30138
thiF
b3992 JW3956 Sulfur carrier protein ThiS adenylyltransferase (EC 2.7.7.n3)Peripheral inner membrane protein or single spanning inner membrane protein (potential).Very strong TMHMM and Phobius and Kyte/Doolittle predictions for at least one TM region. Proteins that have activities as nucleoside-triphosphatase and hydrolysis of thiamin triphosphate in Escherichia coli have been shown to be membrane-bound but there is no experimental evidence for ThiF PMID: 3026493.PMID: 3026493Integral Inner Membrane BBoutin/outN/AMembrane anchoredSRPSECyesyesN590.161CYT0-0.200913-100iCytoplasmic9.2645.7
YAAJ_ECOLIP30143
yaaJ
b0007 JW0006 Uncharacterized transporter yaaJIntegral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN300.113TMH010.2038-990o12-30i68-87o93-116i137-156o176-194i206-228o297-321i342-370o414-438iCytoplasmicMembrane10
YABI_ECOLIP30149
yabI
b0065 JW5005 Inner membrane protein yabIIntegral inner membrane (experimental).Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. PMID: 15919996PMID: 15919996 PMID: 23086209Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN430.146TMH011.6076-550i12-36o56-79i145-165o177-196i217-236oCytoplasmicMembrane1017.57
BASS_ECOLIP30844
basS

pmrB

pmrBb4112 JW4073 Sensor protein BasS (EC 2.7.13.3)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN350.113TMH03.38744-220i14-34o65-85iCytoplasmicMembrane1020.37
EPTA_ECOLIP30845
eptA

pmrC yjdB

pmrC yjdBb4114 JW5730 Phosphoethanolamine transferase eptA (EC 2.7.-.-) (Polymyxin resistance protein pmrC)YjdB co-localizes with the ZipA protein and is involved in cell division. Has been purified as a complex with ZipA-EptA.PMID: 16079137Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.157TMH013.2858-550i12-33o45-66i78-100o120-142i154-176oCytoplasmicMembrane10
BAES_ECOLIP30847
baeS
b2078 JW2063 Signal transduction histidine-protein kinase BaeS (EC 2.7.13.3)Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN310.161TMH06.32525-220i12-31o168-186iCytoplasmicMembrane1031.25
EVGS_ECOLIP30855
evgS
b2370 JW2367 Sensor protein evgS (EC 2.7.13.3) Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 25403562 PMID: 25403562Integral Inner Membrane BBoutout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECYfgMnoyesY220.874SpI217.57923-01Yn3-14c21/22o536-558iCytoplasmicMembrane9.82
YEDE_ECOLIP31064
yedE
b1929 JW1914 UPF0394 inner membrane protein yedEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN240.167TMH016.7358-10100i12-32o81-100i112-136o148-171i197-215o221-240i260-280o292-314i321-341o361-382iCytoplasmicMembrane10
KCH_ECOLIP31069
kch
b1250 JW1242 Putative potassium channel proteinCell inner membrane Integral inner membrane (experimental).PMID: 8824224 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.106TMH02.91162-760i21-39o59-80i87-104o110-127i139-161o200-225iCytoplasmicMembrane10
AAS_ECOLIP31119
aas
b2836 JW2804 Bifunctional protein aas [Includes: 2-acylglycerophosphoethanolamine acyltransferase (EC 2.3.1.40) (2-acyl-GPE acyltransferase) (Acyl-[acyl-carrier-protein]--phospholipid O-acyltransferase); Acyl-[acyl-carrier-protein] synthetase (EC 6.2.1.20) (Acyl-ACP sIntegral membrane protein (experimental; from GenProtEC) Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384Integral Inner Membrane BBpolyout/outSoluble IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN570.217CYT0-0.200913-020o258-277i415-438oCytoplasmicMembrane107.49
SOTB_ECOLIP31122
sotB

ydeA

ydeAb1528 JW1521 Sugar efflux transporterIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN220.15TMH012.9623-12120i12-36o48-68i80-99o105-126i138-156o168-189i210-232o244-265i272-293o299-321i333-352o364-384iCytoplasmicMembrane10
EAMA_ECOLIP31125
eamA

ydeD

ydeDb1533 JW5250 Probable amino-acid metabolite efflux pumpIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN370.113TMH010.8414-10100i7-27o33-52i61-82o88-108i117-135o141-161i173-196o216-237i244-263o269-289iCytoplasmicMembrane104.16
YDEE_ECOLIP31126
ydeE

ydeF

ydeFb1534 JW1527 Uncharacterized MFS-type transporter ydeEIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.123TMH010.3798-1211Yn8-19c24/25o44-63i75-93o99-121i133-156o162-182i207-233o245-263i275-293o299-323i335-357o363-381iCytoplasmicMembrane1094.31
POTH_ECOLIP31135
potH
b0856 JW0840 Putrescine transport system permease protein potHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN580.132CYT0-0.200913-660i31-52o103-122i134-155o185-208i229-253o284-305iCytoplasmicMembrane10
ACRB_ECOLIP31224
acrB

acrE

acrEb0462 JW0451 Acriflavine resistance protein B Alpha-helcal transmembrane protein (experimental). Integral inner membrane (experimental). Cell inner membrane. Integral inner membrane (experimental).AcrB is a major multidrug exporter in Escherichia coli. It cooperates with a membrane fusion protein, AcrA, and an outer membrane channel, TolC (AcrAB-TolC multidrug efflux system) PMID: 15228545. Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertionPMID: 9008159. Exhibites aberrant localization by microscopy in the absence of YidCPMID: 22108384. Crystal structure of AcrB shows three AcrB protomers are organized as a homotrimer in the shape of a jellyfish. In the transmembrane region, each protomer has twelve transmembrane alpha-helicesPMID: 12374972.PMID: 9008159 PMID: 11266632 PMID: 12374972 PMID: 22108384 PMID: 15228545 PMID: 16079137 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)YidCyesyesN550.156TMH04.86972-11120i12-32o340-359i366-390o396-416i437-458o470-493i541-557o875-892i899-919o925-946i975-995o1007-1029iCytoplasmicMembrane10
YICH_ECOLIP31433
yicH
b3655 JW3630 Uncharacterized protein yicHIntegral Inner Membrane BBoutin/outSoluble IM FractionMembrane anchoredSRPSECyesyesN330.134TMH07.0277-110i7-26oUnknown27.22
YICJ_ECOLIP31435
yicJ
b3657 JW5939 Inner membrane symporter yicJIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN570.115TMH02.46347-11120i12-34o40-58i79-98o110-132i152-174o180-202i232-258o264-283i295-313o319-342i363-390o402-424iCytoplasmicMembrane10
SETC_ECOLIP31436
setC

yicK

yicKb3659 JW3633 Sugar efflux transporter CIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN320.244TMH09.2462-1211Yn14-25c33/34o49-70i82-100o106-129i141-161o173-193i221-238o258-277i284-308o314-331i352-368o374-391iCytoplasmicMembrane10
YICL_ECOLIP31437
yicL
b3660 JW3634 Uncharacterized inner membrane transporter yicLIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.389TMH07.96611-109Yn11-18c25/26o41-60i72-94o100-120i127-146o152-172i184-205o217-237i249-270o276-293iCytoplasmicMembrane10
YICO_ECOLIP31440
yicO
b3664 JW5636 Putative permease yicOIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN570.125CYT0-0.200913-13120o33-51i63-86o98-131i143-161o181-199i206-227o247-267i296-318o330-350i357-377o389-413i425-443oCytoplasmicMembrane10
EMRD_ECOLIP31442
emrD

yicQ

yicQb3673 JW5634 Multidrug resistance protein D Alpha-helcal transmembrane protein (experimental). Integral inner membrane (experimental).EmrD is a multidrug transporter from the Major Facilitator Superfamily that expels amphipathic compounds across the inner membrane of Escherichia coli. Crystal structure of EmrD reveals an interior that is composed mostly of hydrophobic residues, which is consistent with its role transporting amphipathic molecules. Two long loops extend into the inner leaflet side of the cell membrane.PMID: 16675700. Exhibites aberrant localization by microscopy in the absence of YidCPMID: 22108384.PMID: 11266632 PMID: 16675700 PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN240.319SpI239.69754-1211Yn9-20c25/26o44-63i75-92o98-116i136-159o165-183i203-226o232-261i273-291o297-318i330-353o365-383iCytoplasmicMembrane10
YIDK_ECOLIP31448
yidK
b3679 JW3655 Uncharacterized symporter yidKIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN230.12CYT0-0.200913-15150o6-22i34-56o76-98i119-141o161-180i192-212o242-261i282-307o327-349i381-397o409-427i434-454o460-481i506-526o532-550iCytoplasmicMembrane10
PTXC_ECOLIP31452
glvC
b3683 JW3660 Putative permease IIC component glvC (PTS system EIIC component)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Integral Membrane Protein (Experimental)SRPSECpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoN510.159TMH011.5504-9100i12-32o63-80i87-109o129-153i174-194o206-222i234-255o275-298i305-323o329-356iCytoplasmicMembrane10
MDTL_ECOLIP31462
mdtL

yidY

yidYb3710 JW3688 Multidrug resistance protein mdtLIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.157TMH02.89051-1111Yn4-12c16/17o40-58i70-89o95-116i128-152o158-178i199-222o242-262i269-287o293-312i324-345o351-376iCytoplasmicMembrane10
ADEP_ECOLIP31466
purP

yieG

yieGb3714 JW3692 Probable adenine permease PurPIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN120.099TMH00.786304-13130i32-56o62-81i88-106o112-130i142-161o181-199i206-226o246-266i295-317o329-349i356-376o388-412i424-442oCytoplasmicMembrane10
HSRA_ECOLIP31474
hsrA

yieO

yieOb3754 JW3733 Probable transport protein hsrA (High-copy suppressor of rspA)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN390.237TMH08.54455-1413Yn10-21c27/28o51-71i78-97o103-124i136-158o164-182i194-211o223-244i264-287o293-314i326-347o353-374i394-417o429-450iCytoplasmicMembrane10
METI_ECOLIP31547
metI

yaeE

yaeEb0198 JW0194 D-methionine transport system permease protein metIIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.111TMH018.923-550o20-40i52-76o82-105i142-162o182-203iCytoplasmicMembrane10
THIP_ECOLIP31549
thiP

yabK

yabKb0067 JW0066 Thiamine transport system permease protein thiPCell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN300.209TMH018.9215-12120i12-38o58-78i90-114o134-151i199-220o240-260i289-311o331-354i375-394o406-424i465-484o504-525iCytoplasmicMembrane1011.38
CAIT_ECOLIP31553
caiT

yaaP

yaaPb0040 JW0039 L-carnitine/gamma-butyrobetaine antiporterCell inner membraneExhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN360.144TMH016.018-12120i12-30o50-71i91-116o145-163i195-216o228-251i263-286o318-335i347-366o406-425i446-466o472-495iCytoplasmicMembrane10
SETA_ECOLIP31675
setA

yabM

yabMb0070 JW0069 Sugar efflux transporter AIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN470.202TMH015.307-1211Yn13-24c32/33o48-70i82-99o105-127i148-166o172-196i217-236o256-275i282-301o307-329i341-363o369-387iCytoplasmicMembrane10
YAAU_ECOLIP31679
yaaU

yabE

yabEb0045 JW0044 Putative metabolite transport protein yaaUIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN300.102TMH07.08001-12120i20-42o54-74i86-104o110-132i144-166o172-193i242-263o283-303i310-329o335-358i370-390o402-421iCytoplasmicMembrane10
DJLA_ECOLIP31680
djlA

yabH

yabHb0055 JW0054 DnaJ-like protein djlACell inner membranePMID: 11106641Integral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell inner membrane | Single-pass type III membrane proteinMembrane anchoredSRPSECyesyesN220.135TMH010.4559-110o6-30iCytoplasmicMembrane1011.88
CHAA_ECOLIP31801
chaA
b1216 JW1207 Calcium/proton antiporterIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN620.229TMH01.59472-11110i15-32o38-60i72-94o106-131i143-164o170-188i221-240o252-269i290-313o319-340i347-365oCytoplasmicMembrane10
YDDA_ECOLIP31826
yddA
b1496 JW5242 Inner membrane ABC transporter ATP-binding protein yddA (CDS102)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.12CYT0-0.200913-550o6-24i31-51o71-90i152-173o193-210iCytoplasmicMembrane10
YIHF_ECOLIP32128
yihF
b3861 JW5574 Uncharacterized protein yihFIntegral inner membranePotential Signal Peptide. It appears to have aminotemrinal TM. It is homologous to YDGA_ECOLI. Integral Inner Membrane BBoutin/outN/AMembrane anchoredSRPSECnoyesN250.128SpI232.38596-10Yn5-13c18/19oCytoplasmicMembrane9.8282.92
YIHG_ECOLIP32129
yihG
b3862 JW3834 Probable acyltransferase yihG (EC 2.3.-.-)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inN/ACell inner membrane | Multi-pass membrane proteinCytoplasmicSRPSECnoyesN410.134TMH09.85797-130o14-47i59-77o97-116iCytoplasmicMembrane1015.46
YIHN_ECOLIP32135
yihN
b3874 JW3845 Inner membrane protein yihNIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinMembrane LipoproteinSRPSECnoyesN230.116SpII155.95413Pos+2=G1211Yn7-17c22/23o46-67i74-90o96-122i143-165o171-189i221-242o248-268i289-308o314-339i351-374o386-406iCytoplasmicMembrane10
YIHO_ECOLIP32136
yihO
b3876 JW5852 Uncharacterized symporter yihOIntegral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN210.104TMH05.69819-11120i17-38o50-74i86-106o118-139i160-179o185-206i238-258o270-291i303-322o328-350i381-402o414-436iCytoplasmicMembrane10
YIHP_ECOLIP32137
yihP
b3877 JW3848 Inner membrane symporter yihPIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN680.101CYT0-0.200913-11110i20-41o53-77i89-109o121-143i164-183o189-210i244-264o276-297i309-328o334-356i421-442oCytoplasmicMembrane10
PTFLB_ECOLIP32154
frvB

yiiJ

yiiJb3899 JW5562 Fructose-like PTS system EIIBC component [Includes: Fructose-like phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system fructose-like EIIB component); Fructose-like permease IIC component (PTS system fructose-like EIIC component)]Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN210.166CYT0-0.200913-9100i139-159o179-198i205-222o228-247i259-281o301-321i342-363o375-396i403-422o442-463iCytoplasmicMembrane10
MENA_ECOLIP32166
menA

yiiW

yiiWb3930 JW3901 1,4-dihydroxy-2-naphthoate octaprenyltransferase (DHNA-octaprenyltransferase) (EC 2.5.1.74)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN360.309TMH04.61773-990i21-38o44-63i98-118o124-143i150-172o178-199i228-246o252-270i290-307oCytoplasmicMembrane1014.32
PTFC2_ECOLIP32672
frwC

yijJ

yijJb3949 JW3921 Fructose-like permease IIC component 2 (PTS system fructose-like EIIC component 2)Integral inner membrane (experimental).Multiphosphoryl transfer protein 2PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN510.192TMH04.57594-890o22-45i57-78o98-120i132-152o172-190i202-229o249-269i281-301o313-334iCytoplasmicMembrane10
YJCC_ECOLIP32701
yjcC
b4061 JW4022 Uncharacterized membrane protein YjcCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN350.165TMH03.89399-220i12-34o243-264iCytoplasmicMembrane10
YJCE_ECOLIP32703
yjcE
b4065 JW4026 Uncharacterized Na(+)/H(+) exchanger yjcEIntegral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN690.131TMH07.97851-11130o6-25i32-50o56-73i85-108o114-136i157-179o185-204i216-235o241-259i280-298o313-337i361-385o397-420iCytoplasmicMembrane10
ACTP_ECOLIP32705
actP

yjcG

yjcGb4067 JW4028 Cation/acetate symporter ActP (Acetate permease) (Acetate transporter ActP)Cell inner membrane Integral inner membrane (experimental).PMID: 16079137 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesY190.597SpI1816.2988-1313Yn4-14c18/19o34-54i75-97o103-122i148-167o179-197i209-227o262-286i298-323o355-383i404-423o429-453i465-486o498-517iCytoplasmicMembrane10
NRFD_ECOLIP32709
nrfD

yjcK

yjcKb4073 JW4034 Protein nrfDCell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.148TMH010.9164-880o18-39i51-73o93-113i150-168o180-203i224-241o261-278i290-312oCytoplasmicMembrane10
NRFE_ECOLIP32710
nrfE

yjcL

yjcLb4074 JW4035 Cytochrome c-type biogenesis protein nrfECell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN100.193TMH07.53708-12120i21-54o79-97i104-126o158-178i190-212o232-248i260-288o294-312i333-357o377-394i401-422o528-545iCytoplasmicMembrane10
MDTO_ECOLIP32715
mdtO

yjcQ

yjcQb4081 JW4042 Multidrug resistance protein mdtOIntegral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.102CYT0-0.200913-990o36-63i75-97o103-120i127-146o152-178i399-420o426-445i457-477o483-502iCytoplasmicMembrane10
MDTN_ECOLIP32716
mdtN

yjcR

yjcRb4082 JW4043 Multidrug resistance protein mdtNIntegral Inner Membrane BBoutin/outN/ACell inner membrane | Single-pass type II membrane proteinMembrane anchoredSRPSECnoyesN470.139SpI357.86193-10Yn15-30c35/36oCytoplasmicMembrane9.82
ALSC_ECOLIP32720
alsC

yjcV

yjcVb4086 JW4047 D-allose transport system permease protein AlsCIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCnoyesN490.11TMH04.98579-980i21-42o71-93i105-129o168-193i222-246o252-272i279-298o304-324iCytoplasmicMembrane10
YEEA_ECOLIP33011
yeeA
b2008 JW1990 Inner membrane protein yeeAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN300.114TMH06.9225-560i20-40o46-66i73-89o95-113i120-136o148-168iCytoplasmicMembrane1032.87
YEEE_ECOLIP33015
yeeE
b2013 JW1995 UPF0394 inner membrane protein yeeEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN590.121TMH04.74224-99Yn6-17c25/26o41-60i72-100o106-123i144-169o198-217i224-241o247-266i287-310o316-337iCytoplasmicMembrane10
NUPX_ECOLIP33021
nupX

yeiJ

yeiJb2161 JW2148 Nucleoside permease nupXIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein(experimental)SRPSECyesyesN570.114TMH03.09344-8100o6-22i29-49o61-82i89-108o114-132i173-195o201-220i258-280o353-380i392-415oCytoplasmicMembrane10
PSUT_ECOLIP33024
psuT

pscT yeiM

pscT yeiMb2164 JW2151 Putative pseudouridine transporterIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN250.143TMH02.44494-8100o6-22i29-49o95-118i173-195o201-220i258-280o286-310i322-341o353-378i390-413oCytoplasmicMembrane10
SETB_ECOLIP33026
setB

yeiO

yeiOb2170 JW2157 Sugar efflux transporter BIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN330.175TMH08.14886-12120i12-33o53-72i84-101o107-129i141-158o164-194i219-244o256-276i283-301o307-330i351-367o373-390iCytoplasmicMembrane10
FLIR_ECOLIP33135
fliR

flaP

flaPb1950 JW1934 Flagellar biosynthetic protein fliRCell inner membrane, Bacterial flagellum basal bodyPMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinBacterial flagellum basal bodyIntegral Membrane ProteinflagellumSRPSECnoyesN610.121TMH05.44162-660o15-33i42-59o65-86i131-151o179-201i213-237oCytoplasmicMembrane10
YEBE_ECOLIP33218
yebE
b1846 JW1835 Inner membrane protein yebEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inN/ACell inner membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN240.329SpI230.790424-220o26-44i56-74oCytoplasmicMembrane1088.71
TORC_ECOLIP33226
torC
b0996 JW0981 Cytochrome c-type protein torC Periplasmic with N-terminal membrane anchor. Single-pass type II membrane protein.TAT secretion system. Binds 5 heme groups per subunit ; Belongs to the torC/torY family. Trimethylamine N-oxide (TMAO) respiration system is encoded by the torCAD operon and comprises a periplasmic TMAO reductase (TorA) and a c-type cytochrome (TorC), which shuttles electrons to TorA. The immature C-terminal domain of TorC strongly down-regulated the tor operon and interacted with the TorS detector region. Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase PMID: 11056172PMID: 17218314 PMID: 11562502 PMID: 11056172Integral Inner Membrane BBoutin/outN/ACell inner membrane | Single-pass type II membrane proteinPeriplasmic with N-terminal membrane anchor (Experimental)SRPSECyesyesN200.12TMH06.50112-110i12-34oCytoplasmicMembrane9.8243.43
LLDP_ECOLIP33231
lldP

lctP

lctPb3603 JW3578 L-lactate permeaseIntegral inner membrane (experimental).Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN660.171TMH011.5559-12120o12-33i40-58o70-95i116-149o155-179i199-217o223-240i252-269o368-387i407-425o431-456i529-550oCytoplasmicMembrane10
YEHW_ECOLIP33359
yehW
b2128 JW2116 Putative osmoprotectant uptake system permease protein yehWIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.403TMH015.5124-65Yn8-22c30/31o46-74i86-111o117-144i164-189o201-226iCytoplasmicMembrane1015.25
YEHY_ECOLIP33361
yehY
b2130 JW2118 Putative osmoprotectant uptake system permease protein yehYIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN300.257TMH013.4216-109Yn9-16c20/21o44-65i72-90o102-123i135-153o183-204i225-246o258-278i324-347o353-379iCytoplasmicMembrane10
YOHD_ECOLIP33366
yohD
b2136 JW2124 Inner membrane protein yohDIntegral inner membrane (experimental).Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF.PMID: 15919996 PMID: 23086209Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN220.131CYT0-0.200913-440i12-35o41-63i122-143o163-180iCytoplasmicMembrane1065.8
NIKB_ECOLIP33591
nikB
b3477 JW3442 Nickel transport system permease protein nikBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.197TMH011.5427-660i9-29o104-125i137-164o176-195i232-255o275-298iCytoplasmicMembrane10
NUOL_ECOLIP33607
nuoL
b2278 JW2273 NADH-quinone oxidoreductase subunit L (EC 1.6.99.5) (NADH dehydrogenase I subunit L) (NDH-1 subunit L) (NUO12)Integral inner membrane (experimental).PMID: 20732298 PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN270.186TMH09.92034-1617Yn4-15c19/20o29-52i64-81o87-104i116-133o139-158i170-189o209-228i249-267o279-300i307-325o331-354i374-392o412-434i455-475o495-513i534-560o593-612iCytoplasmicMembrane10
FEOB_ECOLIP33650
feoB
b3409 JW3372 Ferrous iron transport protein BIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.107CYT0-0.200913-1090o282-302i309-327o347-367i421-447o453-473i511-529o664-685i697-715o721-742iCytoplasmicMembrane108.56
YEJE_ECOLIP33915
yejE
b2179 JW2167 Inner membrane ABC transporter permease protein yejEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN430.206TMH06.40686-660i21-42o142-167i179-197o203-222i259-286o306-327iCytoplasmicMembrane10
CCMF_ECOLIP33927
ccmF

yejR

yejRb2196 JW2184 Cytochrome c-type biogenesis protein CcmFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN540.151TMH012.9934-15150o6-29i41-62o96-114i121-142o178-198i210-230o250-267i274-294o314-332i353-374o394-412i424-444o450-472i484-503o609-629iCytoplasmicMembrane10
NAPH_ECOLIP33934
napH

yejZ

yejZb2204 JW2192 Ferredoxin-type protein napHCell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN470.13TMH07.44595-440i30-50o78-98i139-160o172-192iCytoplasmicMembrane106.33
YOJI_ECOLIP33941
yojI

yojJ

yojJb2211 JW2199 ABC transporter ATP-binding protein yojIIntegral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN300.136TMH012.5457-660i12-36o56-80i125-144o150-169i231-253o273-296iCytoplasmicMembrane1018.16
MDTD_ECOLIP36554
mdtD

yegB

yegBb2077 JW2062 Putative multidrug resistance protein mdtDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN380.206TMH07.65965-13130i12-33o45-64i76-96o102-123i135-157o163-185i197-214o226-243i263-280o286-308i329-355o396-418i430-451oCytoplasmicMembrane10
COBS_ECOLIP36561
cobS
b1992 JW1970 Cobalamin synthase (EC 2.-.-.-)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN580.15TMH03.98364-460i34-58o64-88i109-132o138-158i178-196o202-219iCytoplasmicMembrane102.51
HOFC_ECOLIP36646
hofC

hopC yacD

hopC yacDb0106 JW0102 Protein transport protein hofCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN190.132CYT0-0.200913-340i162-185o216-234i263-281o369-389iCytoplasmicMembrane10
DSBD_ECOLIP36655
dsbD

cutA2 cycZ dipZ

cutA2 cycZ dipZb4136 JW5734 Thiol:disulfide interchange protein dsbD (EC 1.8.1.8) (C-type cytochrome biogenesis protein cycZ) (Inner membrane copper tolerance protein) (Protein-disulfide reductase) (Disulfide reductase)Integral inner membrane (experimental). DsbD is an inner membrane protein that is recognised and targeted to the Sec pathway by short, cleavable, N-terminal signal sequence. PMID: 15919996 Disulfide bridge (122 128;182 304;480 483) PMID: 18406599 PMID: 7628442 PMID: 15919996 Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesY200.853SpI1910.1575-87Yn5-13c19/20o168-195i207-231o243-267i288-317o329-351i363-381o387-406iCytoplasmicMembrane10
PTTBC_ECOLIP36672
treB
b4240 JW4199 PTS system trehalose-specific EIIBC component (EIIBC-Tre) (EII-Tre) [Includes: Trehalose-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system trehalose-specific EIIB component); Trehalose permease IIC component (PTS system trehalose-Inner membrane (experimental). Integral inner membrane (experimental).Trigger factor-sensitive aggregation.PMID: 19737520 PMID: 15919657 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP,TFSECnoyesN440.348CYT0-0.200913-10100i107-131o159-180i187-208o228-245i257-281o301-321i341-361o373-392i399-418o438-461iCytoplasmicMembrane104.32
GSPM_ECOLIP36678
gspM

hopZ pshM

hopZ pshMb3334 JW5704 Putative general secretion pathway protein M (Transport protein pshM)Potential component of type II secretion system.PMID: 14966662 PMID: 11118204Integral Inner Membrane BBinout/inIM (predicted)Cell inner membraneMembrane anchoredSRPSECnoyesN300.121CYT0-0.200913-110o16-34iUnknown2
DTPB_ECOLIP36837
dtpB

yhiP

yhiPb3496 JW3463 Dipeptide and tripeptide permease BIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN610.154TMH06.34727-14140i28-46o52-72i84-101o107-124i145-167o173-193i214-232o238-256i268-285o320-337i349-371o383-408i415-437o457-479iCytoplasmicMembrane10
RSMB_ECOLIP36929
rsmB

fmu/fmv rrmB sun yhdB

fmu/fmv rrmB sun yhdBb3289 JW3250 Ribosomal RNA small subunit methyltransferase B (EC 2.1.1.-) (16S rRNA m5C967 methyltransferase) (rRNA (cytosine-C(5)-)-methyltransferase rsmB)Integral Inner Membrane BBoutin/outIM (predicted)CytoplasmCytoplasmicSRPSECyesyesN680.106CYT0-0.200913-010i76-93oCytoplasmic9.9750.79
CRCB_ECOLIP37002
crcB

ybeI

ybeIb0624 JW0619 Protein CrcBIntegral inner membrane (experimental). Cell inner membraneExhibites aberrant localization by microscopy in the absence of YidC. Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996PMID: 22108384 PMID: 15919996 PMID: 24688744 PMID: 16429150Integral Inner Membrane BBpoly, Bmultiin/out, out/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPYidCyesyesN330.138TMH07.1142-43Yn2-10c15/16o31-55i67-91o97-121iCytoplasmicMembrane1019.65
CLCA_ECOLIP37019
clcA

eriC yadQ

eriC yadQb0155 JW5012 H(+)/Cl(-) exchange transporter ClcA (ClC-ec1) Integral inner membrane (experimental). Integral inner membrane (experimental).Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertionPMID: 9008159. Alpha-helcal transmembrane protein (experimental). The transmembrane segments are all helical and buried within the protein and the membranePMID: 11796999. C-terminal tagging with the alkaline phosphatase and green fluorescent protein in order to define the periplasmic or cytoplasmic locations of the C terminiPMID: 15919996.PMID: 9008159 PMID: 11266632 PMID: 11796999 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN500.115CYT0-0.200913-11100o33-53i74-97o177-201i213-232o252-270i291-308o328-348i355-376o388-413i420-439oCytoplasmicMembrane1038.33
RIR4_ECOLIP37146
nrdF

ygaD

ygaDb2676 JW2651 Ribonucleoside-diphosphate reductase 2 subunit beta (EC 1.17.4.1) (R2F protein) (Ribonucleotide reductase 2)Integral Inner Membrane BBinoutin/outIM (predicted)CytoplasmicSRPSECyesyesN620.104CYT0-0.200913-010i152-172oUnknown231.79
HYBB_ECOLIP37180
hybB
b2995 JW5494 Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunitIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN690.111TMH013.5768-10100i12-31o51-79i91-110o130-154i166-184o211-234i246-264o284-302i314-332o352-373iCytoplasmicMembrane10
YFDC_ECOLIP37327
yfdC
b2347 JW2344 Inner membrane protein yfdCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.112CYT0-0.200913-660i58-76o96-114i135-158o187-206i213-233o253-275iCytoplasmicMembrane1038.43
MDTK_ECOLIP37340
mdtK

norE norM ydhE

norE norM ydhEb1663 JW1655 Multidrug resistance protein mdtK (Multidrug-efflux transporter)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN370.255TMH09.01951-1211Yn10-21c29/30o53-72i92-113o133-149i161-183o189-212i245-268o280-301i313-336o348-366i387-407o419-438iCytoplasmicMembrane10
YCAI_ECOLIP37443
ycaI
b0913 JW5120 Uncharacterized protein ycaIIntegral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN410.135TMH010.6181-7120o23-42i49-69o222-243i255-274o280-297i304-322o328-346i358-383o389-411i423-439o445-467i474-491oCytoplasmicMembrane10
YDHC_ECOLIP37597
ydhC
b1660 JW1652 Inner membrane transport protein ydhCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.384TMH010.7821-1211Yn7-22c30/31o40-61i73-91o97-119i131-155o161-180i209-229o235-258i270-293o299-322i334-355o361-381iCytoplasmicMembrane10
ATZN_ECOLIP37617
zntA

yhhO

yhhOb3469 JW3434 Lead, cadmium, zinc and mercury-transporting ATPase (EC 3.6.3.3) (EC 3.6.3.5)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.185CYT0-0.200913-580i128-144o150-168i180-197o203-222i353-374o380-404i686-702o708-729iCytoplasmicMembrane1026.77
YHHS_ECOLIP37621
yhhS
b3473 JW5945 UPF0226 protein yhhSIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN470.135TMH08.30657-12120i19-41o47-65i85-103o109-131i152-175o181-199i220-241o253-271i283-303o309-330i342-364o370-388iCytoplasmicMembrane10
YHIH_ECOLIP37624
yhiH

yhiG

yhiGb3486 JW5676 Uncharacterized ABC transporter ATP-binding protein yhiHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinCytoplasmicSRPSECyesyesN240.13CYT0-0.200913-560i558-579o716-739i766-789o795-817i824-845o884-906iCytoplasmicMembrane1017.87
YHII_ECOLIP37626
yhiI
b3487 JW3454 Uncharacterized protein yhiIIntegral Inner Membrane BBoutin/outSoluble IM FractionMembrane anchoredSRPSECnoyesN310.132TMH04.13485-110i7-27oCytoplasmicMembrane7.88
YHIM_ECOLIP37630
yhiM
b3491 JW5944 Inner membrane protein yhiMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN330.131TMH011.4226-10100i7-28o40-62i74-95o107-133i154-175o187-211i223-246o258-281i293-313o325-343iCytoplasmicMembrane10
YHIN_ECOLIP37631
yhiN
b3492 JW3459 Uncharacterized protein yhiNIntegral Inner Membrane BBoutin/outN/ACytoplasmicSRPSECyesyesN230.367SpI223.94669-10Yn6-17c22/23oUnknown4.9920.5
MDTF_ECOLIP37637
mdtF

yhiV

yhiVb3514 JW3482 Multidrug resistance protein mdtFCell inner membrane Integral inner membrane (experimental).PMID: 16079137 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN550.14TMH07.6049-11120i12-32o340-359i366-390o396-416i437-458o470-497i539-555o873-890i897-917o923-948i969-989o1009-1031iCytoplasmicMembrane10
YHJD_ECOLIP37642
yhjD
b3522 JW3490 Inner membrane protein yhjDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane, ribosomalB, rBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN480.105CYT0-0.200913-650o72-97i186-209o229-250i262-282o294-321iCytoplasmicMembrane1013.56
YHJE_ECOLIP37643
yhjE
b3523 JW3491 Inner membrane metabolite transport protein yhjEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN450.121CYT0-0.200913-11110o38-54i66-85o97-130i168-188o200-217i249-270o290-312i321-340o346-370i382-403o409-431iCytoplasmicMembrane10
YHJG_ECOLIP37645
yhjG

yhjF

yhjFb3524 JW3492 Uncharacterized protein yhjGIntegral Inner Membrane BBoutin/outIM (predicted)Cell membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN330.12TMH01.70796-110i7-29oUnknown210.91
YHJK_ECOLIP37649
yhjK
b3529 JW5943 Protein YhjKIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN440.106TMH05.39989-220o12-35i151-176oCytoplasmicMembrane10
BCSB_ECOLIP37652
bcsB

yhjN

yhjNb3532 JW3500 Cyclic di-GMP-binding protein (Cellulose synthase regulatory subunit)Integral inner membrane (experimental). BscC is involved in biosynthesis of cellulose, which is a significant constituent of the extracellular matrix. Encodes the catalytic subunit of cellulose synthase. Exhibites aberrant localization by microscopy in the absence of YidC. BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis. 24127606 Cellulose filaments have been visualized in situ via scanning electron and fluorescence microscopy. PMID: 24097954PMID: 2030672 PMID: 22108384 PMID: 15919996 24127606 PMID: 24097954Integral Inner Membrane BBoutout/inIM (predicted)Cell inner membrane | Single-pass type I membrane protein.Integral Membrane ProteinSRPYidCnoyesY260.342SpI2520.4203-21Yn5-13c25/26o745-766iCytoplasmicMembrane1082.28
BCSA_ECOLIP37653
bcsA

yhjO yhjP

yhjO yhjPb3533 JW5665 Cellulose synthase catalytic subunit [UDP-forming] (EC 2.4.1.12) BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis. 24127606 Cellulose filaments have been visualized in situ via scanning electron and fluorescence microscopy. PMID: 2409795424127606 PMID: 24097954Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN160.123CYT0-0.200913-109Yn3-10c15/16o31-50i150-168o174-190i197-216o228-252i524-547o553-575i639-659o665-690iCytoplasmicMembrane10
YHJU_ECOLIP37659
yhjU

yhjU

yhjUb3538 JW3506 Uncharacterized protein yhjUIntegral Inner Membrane BBpolyout/outIM (predicted)Integral Membrane ProteinSRPSECnoyesN520.108TMH09.60827-440o34-56i68-85o113-132i139-162oCytoplasmicMembrane1010.27
YHJV_ECOLIP37660
yhjV
b3539 JW3508 Inner membrane transport protein yhjVIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN340.111TMH010.9997-11110i20-40o46-64i95-118o138-155i167-185o205-227i247-267o294-318i339-362o368-389i401-422oCytoplasmicMembrane10
EPTB_ECOLIP37661
eptB

yhjW

yhjWb3546 JW5660 Phosphoethanolamine transferase eptB (EC 2.7.-.-)Cell inner membrane Integral inner membrane (experimental). Disulfide bond-containing protein PMID: 25664544PMID: 15795227 PMID: 15919996 PMID: 25664544Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN380.136TMH011.408-550i12-30o42-65i77-103o123-140i161-178oCytoplasmicMembrane10
YHJX_ECOLIP37662
yhjX
b3547 JW3516 Inner membrane protein yhjXCell inner membrane Integral inner membrane (experimental).PMID: 23222720 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.124TMH010.8343-12120i12-33o45-66i78-95o101-122i134-154o166-186i216-237o249-270i282-301o307-329i341-360o366-387iCytoplasmicMembrane10
YIAD_ECOLIP37665
yiaD
b3552 JW5657 Inner membrane lipoprotein yiaDLipoprotein (experimental). Outer membrane protein (experimental). Integral inner membrane (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056 PMID: 15919996Integral Inner Membrane, Inner Membrane LipoproteinB, Eout/outN/ACell inner membrane | Multi-pass membrane proteinCell inner membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY180.162SpII2021.9879Pos+2=T32Yn5-16c20/21o36-55i62-81oOuterMembrane1063.67
YIAH_ECOLIP37669
yiaH
b3561 JW3533 Inner membrane protein yiaHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN330.129TMH07.27964-10100i12-29o49-67i79-102o114-131i143-160o172-190i202-224o236-255i267-288o300-321iCytoplasmicMembrane10
YIAN_ECOLIP37675
yiaN
b3578 JW5651 2,3-diketo-L-gulonate TRAP transporter large permease protein yiaNIntegral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN660.188TMH016.4337-11110o12-35i56-75o95-124i136-158o170-191i212-234o240-256i277-295o315-343i355-375o395-419iCytoplasmicMembrane10
YIAV_ECOLIP37683
yiaV
b3586 JW3558 Inner membrane protein yiaVIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBoutin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN160.116TMH01.11111-21Yn3-13c17/18o27-49iCytoplasmicMembrane1022.76
RFBX_ECOLIP37746
rfbX

wzx

wzxb2037 JW2022 Uncharacterized protein yjiSIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN510.11TMH08.627-10120i12-30o42-63i84-106o118-139i146-166o172-196i217-243o263-282i294-316o328-349i361-380o386-407iCytoplasmicMembrane10
RFC_ECOLIP37748
rfc

yefF

yefFb2035 JW2020 Uncharacterized protein yjjJCell inner membranePhobius prediction for a very very weak aminoterminal TMPMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN500.134TMH00.878412-12120i23-43o55-78i99-117o144-161i173-188o194-209i214-233o239-258i270-289o309-332i339-357o363-382iCytoplasmicMembrane10
NARU_ECOLIP37758
narU

yddF

yddFb1469 JW1464 Nitrite extrusion protein 2 (Nitrite facilitator 2)Cell inner membrane Integral inner membrane (experimental).PMID: 18691156 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.118CYT0-0.200913-12120i36-60o72-90i102-122o128-150i171-194o214-232i252-276o288-306i318-340o346-374i401-422o434-454iCytoplasmicMembrane10
YJFF_ECOLIP37772
yjfF
b4231 JW5754 Inner membrane ABC transporter permease protein yjfFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.156TMH09.53051-880o6-23i44-77o89-109i116-134o162-180i211-231o251-274i295-315oCytoplasmicMembrane10
YFJD_ECOLIP37908
yfjD

ypjE

ypjEb4461 JW5415 b2612/b2613UPF0053 inner membrane protein yfjDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)noyesN240.142CYT0-0.200913-440o6-25i62-86o92-112i124-146oCytoplasmicMembrane1011.78
CUSA_ECOLIP38054
cusA

ybdE

ybdEb0575 JW0564 Cation efflux system protein cusAIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN390.202TMH06.2187-12120i12-32o338-357i364-384o390-411i442-464o484-505i538-554o874-891i898-918o924-948i985-1006o1012-1037iCytoplasmicMembrane10
YDJE_ECOLIP38055
ydjE
b1769 JW1758 Inner membrane metabolite transport protein ydjEIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN470.167TMH06.79423-12120i21-40o60-80i92-112o118-139i151-173o179-198i264-287o299-320i327-346o352-375i387-410o416-438iCytoplasmicMembrane10
YEGE_ECOLIP38097
yegE
b2067 JW2052 Probable diguanylate cyclase YegE (DGC) (EC 2.7.7.65)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECnoyesN620.16TMH012.1449-11100i12-33o39-58i65-85o91-112i124-144o156-177i189-206o212-228i235-258o270-290iCytoplasmicMembrane10
EAMB_ECOLIP38101
eamB

yfiK

yfiKb2578 JW2562 Cysteine/O-acetylserine efflux proteinCell inner membrane Integral inner membrane (experimental).PMID: 12562784 PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN450.172TMH07.57291-65Yn4-15c27/28o43-67i74-91o111-133i140-163o175-194iCytoplasmicMembrane10
ETK_ECOLIP38134
etk

yccC

yccCb0981 JW0964 Tyrosine-protein kinase etk (EC 2.7.10.-)Integral inner membrane (experimental). Integral Membrane ProteinPMID: 15919996 PMID: 10369665Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein(experimental)SRPSECnoyesN590.28CYT0-0.200913-220i33-51o425-445iCytoplasmicMembrane1041
LPLT_ECOLIP39196
lplT

ygeD

ygeDb2835 JW2803 Lysophospholipid transporter lplTIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.127TMH08.05882-10110o20-41i53-73o93-117i138-158o164-184i220-245o257-278i285-302o308-329i349-369o375-393iCytoplasmicMembrane10
YFCC_ECOLIP39263
yfcC
b2298 JW2295 Uncharacterized protein yfcCIntegral Inner Membrane BBpolyin/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN490.144TMH03.89092-11130i20-41o106-127i148-165o171-187i194-221o233-252i287-308o314-332i353-371o383-403i410-432o452-471i483-503oCytoplasmicMembrane10
YJDF_ECOLIP39270
yjdF
b4121 JW4082 Inner membrane protein yjdFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN290.268TMH04.29363-660i7-26o32-49i61-83o103-120i132-155o175-194iCytoplasmicMembrane103.22
YJDL_ECOLIP39276
yjdL

dtpC

dtpCb4130 JW4091 Probable dipeptide and tripeptide permease YjdLIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN470.104TMH02.87637-14140i12-35o47-68i75-94o100-116i137-161o167-186i207-228o234-251i263-281o308-329i341-361o373-395i407-428o454-473iCytoplasmicMembrane10
YJEH_ECOLIP39277
yjeH
b4141 JW4101 Inner membrane protein yjeHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN340.297TMH010.0553-1110Yn8-21c33/34o43-66i87-108o120-137i149-166o186-208i220-242o262-287i318-336o342-360i372-405oCytoplasmicMembrane10
YJEM_ECOLIP39282
yjeM
b4156 JW5739 Inner membrane transporter yjeMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.324TMH013.0295-1211Yn10-18c23/24o39-62i83-110o130-149i161-183o203-223i244-264o311-336i357-381o393-412i432-454o466-484iCytoplasmicMembrane10
MSCM_ECOLIP39285
mscM

yjeP

yjePb4159 JW4120 Glutaminase 1Cell inner membranePMID: 22874652Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesY200.667SpI198.61826-1111Yn3-14c19/20o476-496i517-539o551-576i597-617o629-649i670-691o697-718i785-808o828-848i879-897o903-930iCytoplasmicMembrane1015.57
ULAA_ECOLIP39301
ulaA

sgaT yjfS

sgaT yjfSb4193 JW5744 Ascorbate-specific permease IIC component ulaA (Ascorbate-specific PTS system EIIC component)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.105TMH03.53199-10100o15-34i46-66o100-121i142-170o233-253i265-285o305-331i338-359o379-402i423-445oCytoplasmicMembrane10
YTFF_ECOLIP39314
ytfF
b4210 JW4168 Inner membrane protein ytfFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.128TMH08.9392-10100i5-25o31-52i64-86o92-113i125-142o154-175i195-216o231-255i262-281o287-306iCytoplasmicMembrane10
TAMB_ECOLIP39321
tamB

ytfN ytfO

ytfN ytfOb4221 JW4180 Translocation and assembly module TamBInner Membrane b-barrel.Part of the translocation and assembly module (TAM). TAM system promotes efficient secretion of autotransporters in proteobacteria.PMID: 22466966Integral Inner Membrane BBoutin/outN/AMembrane anchoredSRPSECyesyesN240.143SpI257.57895-10Yn8-19c23/24oUnknown4.7231.59
YTFT_ECOLIP39328
ytfT
b4230 JW5753 Inner membrane ABC transporter permease protein ytfTIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN440.117TMH07.85185-10100i21-39o59-77i84-103o109-130i137-155o175-195i224-246o258-275i282-304o310-329iCytoplasmicMembrane10
YJGN_ECOLIP39338
yjgN
b4257 JW5759 Inner membrane protein yjgNIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN570.116TMH03.32963-880o24-45i65-90o96-116i142-164o176-208i229-249o280-299i327-349oCytoplasmicMembrane10
IDNT_ECOLIP39344
idnT

gntW yjgT

gntW yjgTb4265 JW4222 Gnt-II system L-idonate transporter (L-Ido transporter) (5-keto-D-gluconate transporter)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN460.134TMH010.8686-12120i12-38o58-76i97-130o136-154i175-194o222-242i254-275o295-312i324-344o350-369i376-393o413-438iCytoplasmicMembrane10
YJGX_ECOLIP39349
yjgX
b4575 b4275/b4276/b4560Putative phosphoethanolamine transferase yjgX (EC 2.7.-.-)Integral Inner Membrane BBinout/inIM (predicted)CytoplasmicSRPSECpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoN310.126TMH04.71526-110o6-25iCytoplasmicMembrane1049.52
YJHB_ECOLIP39352
yjhB
b4279 JW5768 Putative metabolite transport protein yjhBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN170.101TMH07.56655-11120i21-41o53-73i85-105o111-129i141-160o166-185i215-235o247-271i283-302o308-327i339-362o368-392iCytoplasmicMembrane10
YJHF_ECOLIP39357
yjhF
b4296 JW4258 Uncharacterized protein yoeIIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN390.161TMH04.20538-1211Yn3-13c17/18o27-44i56-76o99-129i136-154o174-193i228-249o261-285i305-327o347-380i387-405o425-448iCytoplasmicMembrane10
SGCC_ECOLIP39365
sgcC

yjhN

yjhNb4304 JW4266 Putative permease IIC component (Putative PTS system EIIC component)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN330.12TMH010.5542-11110o6-25i32-54o85-109i130-152o172-194i214-235o247-268i289-319o325-344i353-374o408-430iCytoplasmicMembrane10
YJIJ_ECOLIP39381
yjiJ
b4332 JW4295 Uncharacterized protein yjiJIntegral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN430.129TMH016.3295-12120i12-34o54-72i84-103o109-131i138-159o171-191i212-235o247-267i274-293o299-321i333-355o361-385iCytoplasmicMembrane10
YJIK_ECOLIP39382
yjiK
b4333 JW5869 Uncharacterized protein yjiKBelongs to the yjiK family.Integral Inner Membrane BBoutin/outN/ACell membrane | Single-pass membrane proteinMembrane anchoredSRPSECnoyesN390.139SpI308.5892-110i12-28oUnknown231.44
YJIN_ECOLIP39385
yjiN
b4336 JW4299 Uncharacterized protein yjiNIntegral Inner Membrane BBpolyin/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN470.127TMH011.0197-330i12-31o43-62i401-421oCytoplasmicMembrane9.46
MDTM_ECOLIP39386
mdtM

yjiO

yjiOb4337 JW4300 Multidrug resistance protein mdtMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.289TMH07.71747-1211Yn9-20c24/25o48-68i80-99o105-126i138-162o168-187i216-241o253-271i283-304o310-335i347-368o374-395iCytoplasmicMembrane10
YJIY_ECOLIP39396
yjiY
b4354 JW5791 Inner membrane protein yjiYCell inner membrane Integral inner membrane (experimental).PMID: 22685278 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN280.119TMH07.29235-16160i12-28o34-54i95-115o121-141i162-185o191-211i223-243o258-278i283-303o323-343i364-387o488-505i533-552o564-589i596-616o669-689iCytoplasmicMembrane10
YJJL_ECOLIP39398
yjjL

yjiZ

yjiZb4356 JW4319 L-galactonate transporterIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN210.161CYT0-0.200913-10100i39-56o108-127i170-192o198-217i260-279o299-321i333-352o358-385i397-415o421-442iCytoplasmicMembrane10
OPGB_ECOLIP39401
mdoB

opgB yjjO

opgB yjjOb4359 JW5794 Phosphoglycerol transferase I (EC 2.7.8.20) (Phosphatidylglycerol--membrane-oligosaccharide glycerophosphotransferase)Cell inner membrane Disulfide bond-containing protein PMID: 25664544PMID: 15919996 PMID: 25664544Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN210.198TMH05.71979-44Yn4-14c18/19o28-47i59-74o80-98i110-128oCytoplasmicMembrane107.34
TTDT_ECOLIP39414
ttdT

ygjC ygjE

ygjC ygjEb3063 JW3035 L-tartrate/succinate antiporter (Tartrate carrier) (Tartrate transporter)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN300.161TMH015.2878-12140i7-27o33-49i56-73o93-116i137-154o192-214i235-258o289-307i312-328o340-364i371-391o397-415i422-442o462-486iCytoplasmicMembrane10
TORS_ECOLIP39453
torS

yccI

yccIb0993 JW5135 Sensor protein torS (EC 2.7.13.3)Cell inner membrane Trimethylamine N-oxide (TMAO) respiration system is encoded by the torCAD operon and comprises a periplasmic TMAO reductase (TorA) and a c-type cytochrome (TorC), which shuttles electrons to TorA. Interaction studies showed that, when immature, TorC can no longer bind TorA efficiently but can bind the periplasmic detector region of sensor TorS. The immature C-terminal domain of TorC strongly down-regulated the tor operon and interacted with the TorS detector region.PMID: 15919996 PMID: 11562502Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN270.124TMH08.89656-220o12-31i331-352oCytoplasmicMembrane1013.43
YBAL_ECOLIP39830
ybaL

ylaA

ylaAb0478 JW0467 Inner membrane protein ybaLIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.134TMH05.87955-12120o6-26i33-51o57-76i88-112o118-136i148-168o180-206i227-260o280-299i306-328o334-361i368-387oCytoplasmicMembrane1036.64
ZNUB_ECOLIP39832
znuB

yebI

yebIb1859 JW1848 High-affinity zinc uptake system membrane protein znuBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.205TMH013.4596-790o6-28i33-51o57-74i86-107o127-145i166-183o189-207i214-233o239-256iCytoplasmicMembrane10
GNTT_ECOLIP39835
gntT

gntM usgA yhgC

gntM usgA yhgCb3415 JW5690 High-affinity gluconate transporter (Gluconate permease) (Gnt-I system)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN280.124TMH09.75395-119Yn3-16c34/35o58-76i97-130o136-154i175-194o224-246i258-278o298-316i337-370o416-437iCytoplasmicMembrane1014.47
YFEH_ECOLIP39836
yfeH
b2410 JW5876 Uncharacterized protein yfeHIntegral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN290.211TMH06.99994-8100i7-24o30-48i69-89o101-119i126-152o164-181i202-221o227-250i262-283o289-311iCytoplasmicMembrane10
RCSD_ECOLIP39838
rcsD

yojN yojP yojQ

yojN yojP yojQb2216 JW2204 Sensor-like histidine kinase RcsDIntegral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinMembrane anchoredSRPSECnoyesN450.148SpI406.36777-120o22-46i309-330oCytoplasmicMembrane1024.22
QSEC_ECOLIP40719
qseC

ygiY

ygiYb3026 JW2994 Sensor protein qseC (EC 2.7.13.3)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.271SpI349.27705-220i12-33o155-182iCytoplasmicMembrane1022.02
NANT_ECOLIP41036
nanT
b3224 JW3193 Putative sialic acid transporter (Sialic acid permease)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN580.109TMH03.96571-12140i21-43o55-74i86-106o112-134i146-165o171-190i224-242o248-267i274-292o312-334i343-361o367-391i403-425o431-452iCytoplasmicMembrane10
GSPF_ECOLIP41441
gspF

hofF hopF

hofF hopFb3327 JW3289 Putative general secretion pathway protein F (Protein transport protein hofF)Integral inner membrane (experimental).Part of gsp locus. Homolog to type two secretion system proteins PulF.PMID: 11118204 PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN670.101CYT0-0.200913-340i164-186o217-236i248-268o370-391iCytoplasmicMembrane1016.5
GSPG_ECOLIP41442
gspG

hofG hopG

hofG hopGb3328 JW3290 Putative general secretion pathway protein G (Protein transport protein hofG)Homolog to major pilin PulG (T2SS). Potential component of type II secretion system. GspG is the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping of the periplasmic piston filaments to achieve secretion. TogetPMID: 20616068 PMID: 14966662 PMID: 11118204 PMID: 23006128 PMID: 18241884Integral Inner Membrane BBoutin/outIM (predicted)Membrane anchoredSRPSECnoyesN360.127CYT0-0.200913-110i12-34oCytoplasmicMembrane9.8246.75
GSPH_ECOLIP41443
gspH

hofH hopH

hofH hopHb3329 JW3291 Putative general secretion pathway protein H (Protein transport protein hofH)Integral inner membrane.GspH is one of four low abundance pseudopillins together with GspI, J and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping of the periplasmic piston filaments to achieve sePMID: 18461043 PMID: 17172336 PMID: 18241884 PMID: 11118204 PMID: 23006128 PMID: 21890895Integral Inner Membrane B-N/AMembrane anchoredSECT2SnoyesN290.113TMH04.86781-110o12-31iCytoplasmicMembrane9.8272.71
YGJI_ECOLIP42590
ygjI
b3078 JW5512 Inner membrane transporter ygjINucleoid (experimental). Integral inner membrane (experimental).PMID: 23138451 PMID: 15919996Nucleoid, Integral Inner Membrane N, Bin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.124TMH05.79735-12120i12-29o41-63i84-108o120-140i152-176o196-220i232-255o287-312i332-353o365-385i406-426o432-452iCytoplasmicMembrane10
ALX_ECOLIP42601
alx

ygjT

ygjTb3088 JW5515 Inner membrane protein alxIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN360.24TMH011.5369-990o6-29i41-63o83-102i114-136o142-161i205-229o235-255i267-286o292-311iCytoplasmicMembrane10
YHAM_ECOLIP42626
yhaM

yhaN

yhaNb4470 JW5518 UPF0597 protein yhaMIntegral Inner Membrane BBoutout/inIM (predicted)CytoplasmicSRPSECpseudogene (Ochman & Davalos, 2006)yesnoN430.167CYT0-0.200913-010o319-340iCytoplasmic9.9783.62
YHAO_ECOLIP42628
yhaO
b3110 JW5519 Inner membrane transport protein yhaOIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN200.128TMH00.623427-11110i38-58o64-82i111-135o155-173i185-206o221-243i264-285o318-339i360-381o387-411i423-442oCytoplasmicMembrane10
YHBX_ECOLIP42640
yhbX
b3173 JW5534 Putative phosphoethanolamine transferase yhbX (EC 2.7.-.-)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN320.175TMH013.1458-560i15-31o37-54i61-82o112-131i143-163o175-195iCytoplasmicMembrane10
PTPC1_ECOLIP42910
agaC

yraE

yraEb3139 JW3108 N-acetylgalactosamine permease IIC component 1 (EIIC-Aga) (PTS system N-acetylgalactosamine-specific EIIC component 1)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN280.124TMH04.72274-64Yn4-15c20/21o97-121i142-164o184-202i209-238oCytoplasmicMembrane102.42
PTPD_ECOLIP42911
agaD

yraF

yraFb3140 JW3109 N-acetylgalactosamine permease IID component (EIID-Aga) (PTS system N-acetylgalactosamine-specific EIID component)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.125CYT0-0.200913-550i96-119o131-151i172-195o215-236i243-262oCytoplasmicMembrane105.17
YNFM_ECOLIP43531
ynfM

yzyC

yzyCb1596 JW1588 Inner membrane transport protein ynfMIntegral inner membrane (experimental).Phobius weak prediction of a hydrophobic TMIn the middle of sequence/Kyte-Doolittle predicts several hydrophobic patches.PMID: 3905795 PMID: 20608695 PMID: 19275539 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN530.119CYT0-0.200913-12120i37-59o71-91i103-122o128-149i156-175o187-208i240-261o267-285i306-323o329-352i364-386o392-411iCytoplasmicMembrane10
PQIB_ECOLIP43671
pqiB

pqi5B

pqi5Bb0951 JW0934 Paraquat-inducible protein BInner membrane (experimental).PMID: 15919657Integral Inner Membrane BBoutin/outIM (predicted), Detected in IM FractionCell membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN420.124TMH06.02674-110i20-38oUnknown2
PITB_ECOLIP43676
pitB
b2987 JW2955 Probable low-affinity inorganic phosphate transporter 2Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.141TMH010.6201-10110o6-26i52-76o96-116i123-143o155-177i208-227o233-255i343-361o381-402i423-442o474-495iCytoplasmicMembrane106.27
YRBG_ECOLIP45394
yrbG
b3196 JW3163 Inner membrane protein yrbGIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN260.208CYT0-0.200913-99Yn2-17c25/26o35-56i68-90o105-122i129-150o170-188i200-219o239-264i276-294o300-319iCytoplasmicMembrane10
DCUD_ECOLIP45428
dcuD

yhcL

yhcLb3227 JW3196 Putative cryptic C4-dicarboxylate transporter dcuDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN300.172TMH02.68784-13120i26-48o68-89i109-128o134-150i157-174o194-215i242-265o271-290i348-369o375-397i409-430o436-454iCytoplasmicMembrane10
YRAQ_ECOLIP45468
yraQ
b3151 JW3120 UPF0718 protein yraQIntegral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN100.146TMH03.98221-990o15-32i72-95o115-134i146-167o173-191i227-249o261-280i287-305o325-345iCytoplasmicMembrane10
KEFB_ECOLIP45522
kefB

trkB

trkBb3350 JW3313 Glutathione-regulated potassium-efflux system protein kefB (K(+)/H(+) antiporter) (NEM-activable K(+)/H(+) antiporter)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.23TMH010.3228-13130o6-25i32-50o56-75i87-107o113-135i147-171o183-201i213-231o237-255i267-285o291-312i324-343o355-373iCytoplasmicMembrane10
YHFK_ECOLIP45537
yhfK
b3358 JW5701 Uncharacterized protein yhfKIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN540.107TMH00.537733-9110o38-55i67-85o91-108i115-133o139-160i371-388o394-411i418-435o441-457i464-481o487-509iCytoplasmicMembrane106.41
FRLA_ECOLIP45539
frlA

yhfM

yhfMb3370 JW3333 Putative fructoselysine transporter frlAIntegral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN200.117TMH013.0134-11120i12-32o44-66i87-113o125-143i155-175o195-219i231-256o276-302i327-347o353-375i387-406o412-434iCytoplasmicMembrane10
YHFT_ECOLIP45546
yhfT
b3377 JW3340 Uncharacterized protein yhfTIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN220.311TMH00.362704-11110o6-28i49-70o90-113i133-153o159-176i183-200o229-249i289-314o320-339i369-397o409-432iCytoplasmicMembrane10
XAPB_ECOLIP45562
xapB
b2406 JW2397 Probable HTH-type transcriptional regulator YjjMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN510.121TMH09.53241-12120i12-30o42-62i71-88o94-114i135-154o160-178i212-235o255-275i282-301o307-327i348-369o381-402iCytoplasmicMembrane10
GSPA_ECOLIP45756
gspA

yheD

yheDb3323 JW3285 Probable general secretion pathway protein AIntegral inner membrane.C-terminus of GspA is in the periplasm. The protein fractionates with the inner membrane. Part of gsp locus.PMID: 11118204 PMID: 21378198Integral Inner Membrane BBinoutin/outIM (predicted)Membrane anchoredSRPSECnoyesN370.16CYT0-0.200913-110i237-257oCytoplasmic9.1275.96
GSPC_ECOLIP45757
gspC

yheE

yheEb3324 JW3286 Probable general secretion pathway protein CIntegral inner membrane Outer membraneHomolog to type two secretion system proteins PulC. Potential component of type II secretion system. A representative PulC-PhoA hybrid protein fractionated mainly with the inner membrane upon isopycnic sucrose gradient centrifugation of membrane vesicles. PMID: 2677007 GspC is the inner membrane component of type II secretion system (T2SS). GspD and the inner membrane protein GspC interact with each other via periplasmic domains (observed in the crystal structure). PMID: 21931548PMID: 14966662 PMID: 11118204 PMID: 2677007 PMID: 21931548Integral Inner Membrane BBinout/inN/ACell inner membraneMembrane anchoredSRPSECnoyesN180.127TMH0-0.020813-110o17-38iUnknown227.4
GSPI_ECOLIP45760
gspI

yheH

yheHb3330 JW5706 Probable general secretion pathway protein IIntegral inner membrane. PeriplasmicPotential component of type II secretion system. GspI is one of four low abundance pseudopillins together with GspH, J and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368PMID: 14966662 PMID: 11118204 PMID: 18241884 PMID: 23006128 PMID: 21890895 PMID: 11266368Integral Inner Membrane BBinout/inN/APeriplasmic (Experimental)SECT2SnoyesN240.233SpI233.86957-110o12-30iCytoplasmicMembrane9.8260.89
GSPL_ECOLIP45763
gspL

yheK

yheKb3333 JW5705 Probable general secretion pathway protein LPotential component of type II secretion system. EspL (GspL homolog) protein interacts through its N-terminal cytoplasmic domain with EspL (GspL homolog) proteinPMID: 14966662 PMID: 11118204 PMCID: PMC398259Integral Inner Membrane BBinoutin/outIM (predicted), Detected in IM FractionCell inner membraneCytoplasmicSRPSECnoyesN450.133CYT0-0.200913-010i242-260oUnknown217.5
YHDX_ECOLIP45767
yhdX
b3269 JW5544 Putative amino-acid ABC transporter permease protein yhdXIntegral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN220.16TMH09.39948-880i21-40o92-114i126-146o181-200i220-241o261-280i335-353o359-384iCytoplasmicMembrane10
YHDY_ECOLIP45768
yhdY
b3270 JW5545 Inner membrane amino-acid ABC transporter permease protein yhdYIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN210.123TMH01.0833-880i28-46o98-119i126-148o160-182i194-219o231-250i292-315o335-352iCytoplasmicMembrane10
IGAA_ECOLIP45800
yrfF
b3398 JW3361 Putative membrane protein igaA homologIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.26SpI184.58634-550o6-22i206-223o229-247i337-358o652-674iCytoplasmicMembrane1026.55
YHGE_ECOLIP45804
yhgE
b3402 JW3365 Uncharacterized protein yhgEIntegral Inner Membrane BBpolyin/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN440.113TMH010.0663-11110i12-33o39-59i66-84o99-118i138-163o183-201i213-236o248-268i289-308o320-341i353-373oCytoplasmicMembrane10
YCIQ_ECOLIP45848
yciQ

yciP

yciPb1268 JW5197 Small toxic protein ibsDIntegral Inner Membrane BBpolyout/inIM (predicted)Integral Membrane ProteinSRPSECnoyesY240.803SpI238.83165-55Yn7-18c23/24o249-266i398-423o429-448i460-480o486-513iCytoplasmicMembrane10
MTGA_ECOLIP46022
mtgA

yrbM

yrbMb3208 JW3175 Monofunctional biosynthetic peptidoglycan transglycosylase (Monofunctional TGase) (EC 2.4.2.-)Integral Inner Membrane BBoutin/outN/ACell membrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN250.133TMH013.1588-110i21-41oCytoplasmicMembrane1011.46
YEDI_ECOLIP46125
yedI
b1958 JW1941 Inner membrane protein yedIIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN300.143CYT0-0.200913-55Yn2-12c30/31o73-102i152-171o177-199i220-249o269-294iCytoplasmicMembrane104.06
ABGT_ECOLIP46133
abgT

ydaH

ydaHb1336 JW5822 ECK1332Aminobenzoyl-glutamate transport proteinCell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN550.352TMH03.72666-13130i30-52o85-104i125-147o153-175i182-202o214-232i260-281o301-322i343-362o382-403i415-434o440-458i470-495oCytoplasmicMembrane10
YDDG_ECOLIP46136
yddG
b1473 JW1469 Inner membrane protein yddGCell inner membrane Integral inner membrane (experimental).PMID: 21042032 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN240.109TMH07.54403-109Yn6-17c26/27o36-57i64-86o92-113i120-138o158-175i182-203o215-235i242-264o270-290iCytoplasmicMembrane10
YFIN_ECOLIP46139
yfiN
b2604 JW2585 Probable diguanylate cyclase YfiN (DGC) (EC 2.7.7.65)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN670.12TMH011.5458-220i21-43o155-177iCytoplasmicMembrane10
AAEB_ECOLIP46481
aaeB

yhcP

yhcPb3240 JW3209 p-hydroxybenzoic acid efflux pump subunit AaeB (pHBA efflux pump protein B)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN540.637TMH06.80417-10100i13-32o38-56i68-87o93-112i119-135o371-395i407-426o432-449i461-480o486-503iCytoplasmicMembrane10
AAEA_ECOLIP46482
aaeA

yhcQ

yhcQb3241 JW3210 p-hydroxybenzoic acid efflux pump subunit AaeA (pHBA efflux pump protein A)Integral inner membrane. Periplasmic PET family proteins are believed to be membrane localized, having 12 predicted transmembrane segments in gram-negative bacteria PMID: 10939244 PMID: 15489430PMID: 10939244 PMID: 15489430Integral Inner Membrane BBoutin/outN/ACell inner membrane | Single-pass membrane proteinPeriplasmic (Experimental)SRPSECyesyesN310.144SpI288.87913-110i12-32oCytoplasmicMembrane9.82
FTSK_ECOLIP46889
ftsK
b0890 JW0873 DNA translocase ftsKCell inner membrane Cell inner membrane Cell inner membrane Integral inner membrane (experimental).PMID: 9723913 PMID: 11703663 PMID: 11948172 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane protein | Cytoplasmic sideIntegral Membrane ProteinSRPSECyesyesN530.169TMH06.50875-550i25-44o75-98i110-131o137-158i165-184oCytoplasmicMembrane1014.84
AER_ECOLIP50466
aer

air yqjJ

air yqjJb3072 JW3043 Aerotaxis receptorCell inner membrane Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 22380631 PMID: 15919996Integral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinMembrane anchoredSRPYidCyesyesN340.205CYT0-0.200913-110i171-200oCytoplasmicMembrane1031.17
TORY_ECOLIP52005
torY

yecK

yecKb1873 JW1862 Cytochrome c-type protein torYIntegral inner membrane Periplasmic with N-terminal membrane anchor Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme. PMID: 11004177 PMID: 11004177Integral Inner Membrane BBoutin/outN/ACell inner membrane | Single-pass type II membrane proteinPeriplasmic with N-terminal membrane anchor (Experimental)SRPSECyesyesN320.123SpI267.35562-10Yn7-18c26/27oUnknown4.9344.83
FSR_ECOLIP52067
fsr
b0479 JW0468 Fosmidomycin resistance proteinIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN290.107TMH04.87385-10110o26-50i62-84o104-130i151-175o181-202i223-242o262-282i294-313o319-340i352-375o381-399iCytoplasmicMembrane10
HISQ_ECOLIP52094
hisQ
b2308 JW2305 Histidine transport system permease protein hisQIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN280.408TMH06.17401-550o12-35i47-70o90-108i149-171o191-215iCytoplasmicMembrane108.22
GLRK_ECOLIP52101
glrK

yfhK

yfhKb2556 JW5407 Putative sensor-like histidine kinase yfhK (EC 2.7.13.3)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBinoutout/inIM (predicted)Cell inner membrane | Single-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.258SpI308.61403-21Yn14-24c30/31o174-198iCytoplasmicMembrane1018.94
YFJV_ECOLIP52137
yfjV

ypjM

ypjMb2641 b2639 b2640Putative arsenical pump membrane protein (Fragment)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Integral Membrane ProteinSRPSECpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoN240.148TMH06.85294-880o22-40i47-69o81-107i131-149o155-172i184-205o225-243i310-332oCytoplasmicMembrane10
YFJW_ECOLIP52138
yfjW
b2642 JW2623 Uncharacterized protein yfjWIntegral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECProphage Integrase (EcoGene)nonoN470.122TMH06.6613-560i20-46o66-89i96-118o130-151i163-188o536-557iCytoplasmicMembrane10
EMRY_ECOLIP52600
emrY
b2367 JW2364 Multidrug resistance protein YIntegral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN400.184TMH010.5527-13130i12-32o55-73i85-104o110-132i144-165o171-193i205-224o236-255i276-295o307-325i337-355o375-394i484-502oCytoplasmicMembrane10
YCCM_ECOLIP52636
yccM
b0992 JW0977 Putative electron transport protein yccMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN480.107CYT0-0.200913-550i37-54o96-114i159-180o200-218i307-332oCytoplasmicMembrane1012.56
YDBH_ECOLIP52645
ydbH
b1381 JW1376 Uncharacterized protein ydbHUncharacterized, echolocation Signal peptide may be membrane anchored or cleaved and the protein therefore exported (signalP score near threshold). BOMP reliability scores are below 2 and so this is unlikely to be an OMP.Integral Inner Membrane BBoutin/outN/AMembrane anchoredSRPSECnoyesN350.163TMH06.49797-10Yn7-26c34/35oCytoplasmicMembrane9.8212.9
YBHD_ECOLIP52696
ybhD
b0768 JW5896 Phenylacetic acid degradation protein paaBNucleoid Integral Inner membrane Uncharacterized HTH-type transcriptional regulator Nucleoid, Integral Inner Membrane N, BN/AMembrane anchoredSRPSECnoyesN240.184CYT0-0.200913-110i94-112oCytoplasmic9.97
HRSA_ECOLIP54745
hrsA
b0731 JW0720 Heat-responsive suppressor hrsA (Putative PTS system EIIABC component) [Includes: Phosphotransferase enzyme IIA component (EC 2.7.1.-) (PTS system EIIA component); Phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system EIIB component); PermeaseIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN370.104CYT0-0.200913-980i310-337o357-376i388-414o434-454i466-486o498-518i574-596o616-641iCytoplasmicMembrane1037.92
YGCG_ECOLIP55140
ygcG
b2778 JW5445 UPF0603 protein ygcGIntegral Inner Membrane BBpoly-IM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesY180.242SpI174.90841-23Yn4-12c17/18o176-194i206-222o228-249iCytoplasmicMembrane10
YGAP_ECOLIP55734
ygaP
b2668 JW2643 Inner membrane protein ygaPIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN120.121CYT0-0.200913-220i117-135o141-165iCytoplasmicMembrane1028.31
YBGT_ECOLIP56100
ybgT
b4515 JW0724 Uncharacterized protein ybgTSmall membrane protein (experimental). Inner membrane.Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(out)-C(in). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased.PMID: 19121005 PMID: 21778229 PMID: 21778229Integral Inner Membrane BBinoutin/outN/AMembrane | Single-pass membrane proteinCytoplasmicSRPYidCnoyesN240.168SpI233.08714-10Yn4-15c23/24oUnknown2
PTHC_ECOLIP56579
srlA

gutA sbl

gutA sblb2702 JW5429 Glucitol/sorbitol permease IIC component (EIIC-Gut) (PTS system glucitol/sorbitol-specific EIIC component)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN460.112CYT0-0.200913-330o22-48i69-91o122-149iCytoplasmicMembrane1017.2
PTHB_ECOLIP56580
srlE

gutE

gutEb2703 JW5430 Glucitol/sorbitol-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (EII-Gut) (PTS system glucitol/sorbitol-specific EIIB component)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN220.109CYT0-0.200913-460i147-165o177-197i204-226o232-250i257-280o300-318iCytoplasmicMembrane1017.61
ADIC_ECOLIP60061
adiC

aniC yjdD yjdE

aniC yjdD yjdEb4115 JW4076 Arginine/agmatine antiporterIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN620.127TMH08.65108-12120i12-35o41-61i91-116o122-141i153-173o193-217i229-254o274-296i317-340o352-374i386-404o410-428iCytoplasmicMembrane10
MSBA_ECOLIP60752
msbA
b0914 JW0897 Lipid A export ATP-binding/permease protein msbA (EC 3.6.3.-)Cell inner membrane Integral inner membrane (experimental).PMID: 8809774 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN390.127TMH07.05231-560i21-45o65-93i142-163o169-186i244-269o275-295iCytoplasmicMembrane1011.74
TSGA_ECOLIP60778
tsgA

gutS yhfC yhfH

gutS yhfC yhfHb3364 JW3327 Protein tsgAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.126TMH017.4563-12120i12-35o47-66i78-97o103-122i134-157o163-183i204-229o249-268i273-289o295-317i329-352o358-381iCytoplasmicMembrane10
PLSY_ECOLIP60782
plsY

ygiH

ygiHb3059 JW3031 Probable glycerol-3-phosphate acyltransferase (G3P acyltransferase) (GPAT) (EC 2.3.1.15) (EC 2.3.1.n5) (Lysophosphatidic acid synthase) (LPA synthase)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.12TMH01.31378-550o6-28i49-68o80-102i109-132o138-158iCytoplasmicMembrane1017.16
AQPZ_ECOLIP60844
aqpZ

bniP

bniPb0875 JW0859 Aquaporin Z (Bacterial nodulin-like intrinsic protein) Integral inner membrane (experimental). Cell inner membrane Cell inner membrane Integral inner membrane (experimental).Exhibites aberrant localization by microscopy in the absence of YidCPMID: 22108384. AqpZ forms tetramer in the inner membranePMID: 14691544. Sucrose gradient sedimentation analysis showed that the native, solubilized AqpZ protein is a trypsin-resistant tetramerPMID: 10518952. Upon reconstitution into proteoliposomes, AqpZ displays very high osmotic water permeability. No permeation by glycerol, urea or sorbitol was detectedPMID: 10518952. Electron crystallography has shown monomers to consist of six membrane spanning alpha-helices confirming sequence based predictionsPMID: 10487750.PMID: 11266632 PMID: 14691544 PMID: 22108384 PMID: 10518952 PMID: 10487750 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN430.268TMH014.8231-65Yn5-17c26/27o36-60i81-103o129-149i161-180o206-226iCytoplasmicMembrane10
YBJL_ECOLIP60869
ybjL
b0847 JW0831 Putative transport protein ybjLIntegral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN230.115TMH04.04335-9100o12-30i37-55o61-85i92-114o161-181i383-403o409-426i447-464o476-498i532-557oCytoplasmicMembrane10
YIDE_ECOLIP60872
yidE

yibE

yibEb3685 JW3662 Putative transport protein yidEIntegral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.131TMH07.15912-10110o6-22i29-47o67-86i93-115o162-182i371-391o397-417i429-446o466-485i492-513o533-552iCytoplasmicMembrane10
UPPP_ECOLIP60932
uppP

bacA upk

bacA upkb3057 JW3029 Undecaprenyl-diphosphatase (EC 3.6.1.27) (Bacitracin resistance protein) (Undecaprenyl pyrophosphate phosphatase)Cell inner membrane Cell inner membranePMID: 15138271 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.112TMH02.62176-77Yn6-13c18/19o50-69i90-110o116-136i157-175o195-213i225-246o252-272iCytoplasmicMembrane10
LGT_ECOLIP60955
lgt

umpA

umpAb2828 JW2796 Prolipoprotein diacylglyceryl transferase (EC 2.4.99.-)Integral inner membrane (experimental).PMID: 8051048 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN380.128TMH09.00412-570o14-40i60-80o100-118i130-148o200-218i225-242o262-282iCytoplasmicMembrane1010.92
OPGH_ECOLIP62517
mdoH

opgH

opgHb1049 JW1037 Glucans biosynthesis glucosyltransferase H (EC 2.4.1.-)Inner membrane (experimental). Integral inner membrane (experimental). Septal ring. Integral inner membrane.Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. OpgH localizes to the nascent septal site, where it antagonizes assembly of the tubulin-like cell division protein FtsZ, delaying division and increasing cell size.PMID: 9008159 PMID: 15919657 PMID: 15919996 PMCID: PMC3723540Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN350.119CYT0-0.200913-680i139-156o188-221i512-533o566-590i599-617o623-640i660-676o682-706iCytoplasmicMembrane103.82
YEIH_ECOLIP62723
yeiH
b2158 JW2145 UPF0324 inner membrane protein yeiHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN410.241TMH013.02-8110i12-32o38-58i79-98o104-122i134-151o163-185i197-219o225-246i266-284o290-311i323-344oCytoplasmicMembrane10
KUP_ECOLIP63183
kup

trkD

trkDb3747 JW5609 Low affinity potassium transport system protein kup (Kup system potassium uptake protein)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)yesyesN230.142TMH05.56396-1211Yn9-17c22/23o48-69i102-129o141-157i169-190o210-233i245-267o287-316i337-357o363-383i395-413o419-440iCytoplasmicMembrane10
GADC_ECOLIP63235
gadC

acsA xasA

acsA xasAb1492 JW1487 Probable glutamate/gamma-aminobutyrate antiporter (Extreme acid sensitivity protein)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN290.285TMH015.6618-12120i12-30o42-66i87-108o128-146i158-178o198-217i238-260o288-310i337-356o368-392i413-432o444-466iCytoplasmicMembrane10
YQEG_ECOLIP63340
yqeG
b2845 JW2813 Inner membrane transport protein yqeGIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN230.142TMH09.79347-10110i12-30o36-53i92-112o124-145i152-173o193-216i236-261o281-302i334-355o361-381i390-408oCytoplasmicMembrane10
ZNTB_ECOLIP64423
zntB

ydaN

ydaNb1342 JW1336 Zinc transport protein zntBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.108CYT0-0.200913-220i268-289o301-321iCytoplasmicMembrane1082.25
YPJD_ECOLIP64432
ypjD
b2611 JW2592 Inner membrane protein ypjDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN180.156CYT0-0.200913-87Yn3-12c17/18o33-51i63-84o90-112i124-146o176-198i210-226o238-258iCytoplasmicMembrane10
YECN_ECOLIP64515
yecN
b1869 JW5308 Inner membrane protein yecNIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Single-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN210.119CYT0-0.200913-32Yn4-14c18/19o72-92i104-122oCytoplasmicMembrane1050.17
YQJD_ECOLIP64581
yqjD
b3098 JW3069 Uncharacterized protein yqjDIntegral inner membrane (experimental). Cell inner membrane Inner membrane, ribosomal binding Integral inner membrane. Ribosome.YqJD is expressed during the stationary growth phase. YqjD possesses a transmembrane motif in the C-terminal region and associates with 70S and 100S ribosomes at the N-terminal region. Expressed during the stationary growth phase, and expression is regulated by stress response sigma factor RpoS. YqjD possesses a transmembrane motif in the C-terminal region and associates with 70S and 100S ribosomes at the N-terminal region. PMID: 22661687 YqjD is an inner membrane protein associated with stationary-phase ribosomes. PMID: 22661687PMID: 22661687 PMID: 22380631 PMID: 22661687 PMID: 22661687Integral Inner Membrane, ribosomalB, rBoutIM (predicted), Detected in IM FractionMembrane anchoredSRPSECnoyesN330.103CYT0-0.200913-110o81-99iUnknown2
MLAE_ECOLIP64606
mlaE

yrbE

yrbEb3194 JW3161 Probable phospholipid ABC transporter permease protein mlaECell inner membrane Integral inner membrane (experimental).PMID: 19383799 PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN670.105CYT0-0.200913-560i48-69o75-96i103-125o148-177i198-219o239-258iCytoplasmicMembrane10
YGDQ_ECOLIP67127
ygdQ
b2832 JW2800 UPF0053 inner membrane protein ygdQIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN490.35TMH03.66789-770o12-38i50-71o77-101i122-141o153-172i184-201o213-230iCytoplasmicMembrane1017.05
YQFA_ECOLIP67153
yqfA
b2899 JW2867 UPF0073 inner membrane protein yqfAIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN490.173TMH03.45027-770i21-42o54-74i86-105o111-132i139-157o163-186i195-216oCytoplasmicMembrane10
XANQ_ECOLIP67444
xanQ

ygfO

ygfOb2882 JW2850 Xanthine permease XanQCell inner membrane Integral inner membrane (experimental).PMID: 16096267 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN590.123CYT0-0.200913-12120i24-50o56-74i81-104o116-142i154-175o187-204i211-231o251-275i338-360o366-388i395-412o424-446iCytoplasmicMembrane10
AAER_ECOLIP67662
aaeR

yhcS

yhcSb3243 JW3212 HTH-type transcriptional activator AaeRNucleoid (experimental).PMID: 23138451Nucleoid, Integral Inner Membrane N, BIM (predicted)CytoplasmicSRPSECyesyesN240.199CYT0-0.200913-010i226-245oCytoplasmic9.97
YFEO_ECOLIP67729
yfeO
b2389 JW2386 Putative ion-transport protein yfeOIntegral Inner Membrane BBpolyin/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.188TMH012.9661-11110i12-37o57-77i98-117o147-170i182-203o223-245i257-281o301-318i325-340o346-364i371-398oCytoplasmicMembrane10
MALG_ECOLIP68183
malG
b4032 JW3992 Maltose transport system permease protein malGCell inner membrane Cell inner membrane Integral inner membrane (experimental). Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. Crystal structure of a catalytic intermediate of the maltose transporter. PMID: 18033289PMID: 9008159 PMID: 2233678 PMID: 18456666 PMID: 15919996 PMID: 18033289Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECnoyesN370.136TMH014.3943-660i12-39o91-110i122-143o163-181i202-227o258-281iCytoplasmicMembrane10
ATPL_ECOLIP68699
atpE

papH uncE

papH uncEb3737 JW3715 ATP synthase subunit c (ATP synthase F(0) sector subunit c) (Dicyclohexylcarbodiimide-binding protein) (F-type ATPase subunit c) (F-ATPase subunit c) (Lipid-binding protein)Integral inner membrane (experimental). Integral Membrane ProteinExperimentally verified gene-productPMID: 9868784. Methionine start codon is cleavedPMID: 9868784. Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreasedPMID: 15263011PMID: 21778229. PMID: 9237612PMID: 9868784 PMID: 15263011 PMID: 21778229 PMID: 15919996 PMID: 9237612Integral Inner Membrane BBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPYidCnoyesN280.117TMH07.95599-220o12-32i53-76oCytoplasmicMembrane1056.33
DHSC_ECOLIP69054
sdhC

cybA

cybAb0721 JW0711 Succinate dehydrogenase cytochrome b556 subunit (Cytochrome b-556) Integral inner membrane (experimental). Integral inner membrane (experimental).Alpha-helcal transmembrane protein (experimental). Transmembrane helices: 3 PMID: 12560550.PMID: 11266632 PMID: 12560550 PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.129TMH01.73943-330i20-48o68-89i110-128oCytoplasmicMembrane1042.56
MDTH_ECOLIP69367
mdtH

yceL

yceLb1065 JW1052 Multidrug resistance protein mdtHIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN80.11TMH012.8944-10120i12-35o41-58i78-94o100-116i136-157o163-185i210-235o247-264i276-294o300-317i337-357o369-388iCytoplasmicMembrane10
FIEF_ECOLIP69380
fieF

yiiP

yiiPb3915 JW3886 Ferrous-iron efflux pump fieFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.141TMH03.82255-660i12-33o39-60i81-106o118-138i158-175o181-199iCytoplasmicMembrane10
TATC_ECOLIP69423
tatC

mttB yigU yigV

mttB yigU yigVb3839 JW3815 Sec-independent protein translocase protein tatCCell inner membrane Cell inner membrane Cell inner membrane Integral inner membrane (experimental).PMID: 11591389 PMID: 15225613 PMID: 20169075 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN390.339TMH04.27208-660i20-38o74-95i116-137o157-183i195-212o218-237iCytoplasmicMembrane1065.76
TATB_ECOLIP69425
tatB

mttA2 ysgB

mttA2 ysgBb3838 JW5580 Sec-independent protein translocase protein tatBCell inner membrane Cell inner membrane Cell inner membrane Membrane anchoredPMID: 11591389 PMID: 15225613 PMID: 20169075 PMID: 14580344Integral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchored (Experimental)SRPSECyesyesN440.115CYT0-0.200913-10Yn9-20c28/29oCytoplasmicMembrane10
TATA_ECOLIP69428
tatA

mttA1 yigT

mttA1 yigTb3836 JW3813 Sec-independent protein translocase protein tatAInner Memrane (experimental). Inner Memrane (experimental). Inner Memrane (experimental). Membrane anchoredTatA-GFP was distributed in the membrane, often with higher abundance at the poles. PMID: 14580344PMID: 11591389 PMID: 15225613 PMID: 20169075 PMID: 14580344Integral Inner Membrane BBinout/inIM (predicted), Detected in IM FractionCell inner membrane | Single-pass membrane protein | Cytoplasmic sideMembrane anchored (Experimental)SRPSECyesyesN430.112CYT0-0.200913-110o6-22iCytoplasmicMembrane10
CCME_ECOLIP69490
ccmE

yejS

yejSb2197 JW2185 Cytochrome c-type biogenesis protein CcmE (Cytochrome c maturation protein E) (Heme chaperone CcmE) Periplasmic with N-terminal membrane anchor Periplasmic with N-terminal membrane anchor CcmC, CcmE, and heme interact directly with each other, establishing a periplasmic heme delivery pathway for cytochrome c maturation. PMID: 11384983 PMID: 9770295 PMID: 16364305PMID: 11384983 PMID: 9770295 PMID: 16364305Integral Inner Membrane BBoutin/outN/ACell inner membrane | Single-pass type II membrane protein | Periplasmic sidePeriplasmic with N-terminal membrane anchor (Experimental)SRPSECyesyesN290.181TMH08.60358-110i9-30oCytoplasmic8.9666.48
AMTB_ECOLIP69681
amtB

ybaG

ybaGb0451 JW0441 Ammonia channel (Ammonia transporter) Integral inner membrane (experimental). Integral Membrane Protein. Integral inner membrane (experimental). Integral Membrane Protein Integral Membrane Protein Integral Membrane ProteinExhibites aberrant localization by microscopy in the absence of YidC. PMID: 9720863 PMID: 10231487 PMID: 11847102 PMID: 14668330PMID: 11266632 PMID: 15361618 PMID: 22108384 PMID: 11847102 PMID: 15919996 PMID: 9720863 PMID: 10231487 PMID: 14668330Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPYidCyesyesY230.645SpI2212.8449-1211Yn3-14c22/23o32-54i66-86o120-142i149-171o183-205i217-236o248-268i280-297o303-324i336-356o376-396iCytoplasmicMembrane10
PTGCB_ECOLIP69786
ptsG

glcA umg

glcA umgb1101 JW1087 PTS system glucose-specific EIICB component (EIICB-Glc) (EII-Glc) [Includes: Glucose permease IIC component (PTS system glucose-specific EIIC component); Glucose-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system glucose-specific EPeripheral inner membrane protein facing the cytoplasm (experimental). Peripheral inner membrane protein facing the cytoplasm. Inner membrane (experimental). Integral inner membrane (experimental).PMID: 12717030 PMID: 15650111 PMID: 15919657 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN380.133TMH012.5578-1090o16-39i51-71o77-101i113-132o152-172i254-272o278-297i304-331o354-376iCytoplasmicMembrane103.15
PTNC_ECOLIP69801
manY

pel ptsP

pel ptsPb1818 JW1807 Mannose permease IIC component (EII-P-Man) (EIIC-Man) (PTS system mannose-specific EIIC component)Inner membrane protein (experimental). Peripheral inner membrane protein facing the cytoplasm. Integral inner membrane (experimental).PTS transport system component and membrane localized in complexomics study by (Stenberg et al., 2005)PMID: 15911532 PMID: 16079137 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.11TMH06.083-770o6-24i33-56o62-86i98-124o144-165i177-197o209-239iCytoplasmicMembrane10
PTND_ECOLIP69805
manZ

gptB ptsM

gptB ptsMb1819 JW1808 Mannose permease IID component (EII-M-Man) (EIID-Man) (PTS system mannose-specific EIID component)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane | Single-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.108CYT0-0.200913-330i130-154o238-255i262-282oCytoplasmicMembrane1029.9
PTMCB_ECOLIP69826
cmtA
b2933 JW2900 PTS system mannitol-specific cryptic EIICB component (EIICB-Mtl) (EII-Mtl) [Includes: Mannitol permease IIC component (PTS system mannitol-specific EIIC component); Mannitol-specific phosphotransferase enzyme IIB component (EC 2.7.1.69) (PTS system mannitPeripheral inner membrane protein facing the cytoplasm. Cell inner membraneMannitol-specific cryptic phosphotransferase enzyme IIA component. Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 12558186 PMID: 9525892 PMID: 9260961 PMID: 22108384 PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPYidCyesyesN510.119TMH014.5212-880i12-40o52-74i86-114o134-158i214-235o247-266i287-307o313-335iCytoplasmicMembrane10
PTKC_ECOLIP69831
gatC
b2092 JW2076 Galactitol permease IIC component (EIIC-Gat) (PTS system galactitol-specific EIIC component)Cell inner membrane Cell inner membranePTS system galactitol-specific EIIC component.The galactitol phosphotransferase system transporter (EIIGat) is also composed of three subunits, GatA (IIAGat), GatB (IIBGat), and GatC (IICGat). These three subunits assemble in a 1:1:2 stoichiometry to form a complex with a predicted molecular mass of ∼122 kDaPMID: 16079137 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN340.145TMH00.817461-11110o12-29i41-58o91-113i134-158o178-198i218-239o245-264i298-322o328-346i353-371o417-435iCytoplasmicMembrane10
SUGE_ECOLIP69937
sugE
b4148 JW5738 Quaternary ammonium compound-resistance protein sugECell inner membrane Integral inner membrane (experimental). Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996PMID: 14728684 PMID: 15919996 PMID: 24688744 PMID: 16429150Integral Inner Membrane BBpoly, Bmultiin/out, out/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN610.195TMH010.6118-43Yn4-12c17/18o33-50i57-79o85-103iCytoplasmicMembrane10
WCAD_ECOLIP71238
wcaD
b2056 JW2041 Putative colanic acid polymeraseCell inner membranePMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.141TMH02.50534-11110i7-25o31-48i55-73o85-105i117-138o172-191i203-226o246-266i278-296o328-347i368-397oCytoplasmicMembrane10
WCAJ_ECOLIP71241
wcaJ
b2047 JW2032 Putative colanic biosynthesis UDP-glucose lipid carrier transferaseCell inner membrane Integral inner membrane (experimental).PMID: 22408159 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN320.107TMH04.26813-550i12-34o46-69i81-101o113-137i279-300oCytoplasmicMembrane10
YAGG_ECOLIP75683
yagG
b0270 JW0263 Uncharacterized symporter yagGIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)yesnoN580.129TMH04.66722-12120i12-34o40-59i80-101o107-130i150-172o178-199i233-255o267-287i294-311o317-340i360-384o404-426iCytoplasmicMembrane10
YAHN_ECOLIP75693
yahN
b0328 JW0320 Uncharacterized membrane protein yahNIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN200.167TMH06.85455-660o20-42i54-79o85-103i136-153o159-179i199-217oCytoplasmicMembrane1045.29
ALLP_ECOLIP75712
ybbW

glxB2

glxB2b0511 JW0499 Putative allantoin permease (Allantoin transport protein)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN430.107TMH01.55234-12120i46-79o91-110i117-139o151-174i186-212o224-245i266-288o308-328i349-367o373-397i417-439o451-468iCytoplasmicMembrane10
DTPD_ECOLIP75742
dtpD

ybgH

ybgHb0709 JW0699 Dipeptide permease DIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN480.16TMH01.28832-14140i12-36o48-69i78-96o102-121i142-162o168-187i208-231o237-255i267-284o304-332i344-365o377-398i410-430o462-479iCytoplasmicMembrane10
ABRB_ECOLIP75747
abrB

ybgN

ybgNb0715 JW5097 ECK0704Protein AbrB (AidB regulator)Cell inner membranePMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN230.182TMH011.997-790o6-32i53-75o81-103i144-162o174-200i207-224o230-247i259-280o323-343iCytoplasmicMembrane10
ZITB_ECOLIP75757
zitB

ybgR

ybgRb0752 JW0735 Zinc transporter zitBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN520.121TMH05.6947-560i21-41o47-68i89-110o122-143i155-182o188-205iCytoplasmicMembrane10
YBHI_ECOLIP75763
ybhI
b0770 JW0753 Uncharacterized protein ymgIIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN270.378TMH013.1359-15140i7-25o31-48i55-71o91-108i120-141o147-166i178-198o218-244i273-291o297-315i327-345o365-381i388-415o445-468iCytoplasmicMembrane10
YBHN_ECOLIP75770
ybhN
b0788 JW0771 Inner membrane protein ybhNIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.118TMH010.4723-87Yn14-27c31/32o47-65i85-106o126-151i163-186o206-227i234-266o286-303iCytoplasmicMembrane10
YBHG_ECOLIP75777
ybhG
b0795 JW0779 UPF0194 membrane protein ybhGInner membrane.PMID: 17446557Integral Inner Membrane BSoluble IM FractionPeriplasmMembrane anchoredSRPSECyesyesN260.132SpI206.65671-10Yn6-16c20/21oCytoplasmicMembrane9.8231.68
YBIO_ECOLIP75783
ybiO
b0808 JW5108 Uncharacterized mscS family protein ybiOCell inner membrane Integral inner membrane (experimental).PMID: 22874652 PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesY190.624SpI1812.9319-1111Yn3-13c18/19o141-163i183-205o225-244i268-286o292-315i335-361o381-399i419-446o466-488i509-531o537-559iCytoplasmicMembrane1022.41
YBIP_ECOLIP75785
ybiP
b0815 JW0800 Putative phosphoethanolamine transferase ybiP (EC 2.7.-.-)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN220.112TMH06.83717-440o34-54i63-84o104-127i139-158oCytoplasmicMembrane106.81
YBIR_ECOLIP75788
ybiR
b0818 JW0802 Inner membrane protein ybiRIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN390.126TMH06.01785-9100o14-32i44-64o84-108i120-140o160-182i202-217o223-241i248-268o312-335i347-369oCytoplasmicMembrane10
GSIC_ECOLIP75798
gsiC

yliC

yliCb0831 JW0815 Glutathione transport system permease protein gsiCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.137TMH06.79337-660i9-30o99-123i135-155o170-191i227-249o278-299iCytoplasmicMembrane102.77
GSID_ECOLIP75799
gsiD

yliD

yliDb0832 JW0816 Glutathione transport system permease protein gsiDIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN660.123CYT0-0.200913-660i40-61o103-129i136-158o164-183i222-247o267-290iCytoplasmicMembrane1010.15
YLIE_ECOLIP75800
yliE
b0833 JW0817 Uncharacterized membrane protein yoaKIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionIntegral Membrane ProteinSRPSECnoyesN280.121TMH01.46888-220i12-32o286-304iCytoplasmicMembrane7.884.33
YLIF_ECOLIP75801
yliF
b0834 JW0818 Putative lipoprotein YliFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBinoutout/inIM (predicted)Cell membrane | Single-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN240.568SpI237.00044-21Yn7-17c25/26o231-251iCytoplasmicMembrane1010.11
YBJG_ECOLIP75806
ybjG
b0841 JW5112 Putative undecaprenyl-diphosphatase ybjG (EC 3.6.1.27) (Undecaprenyl pyrophosphate phosphatase)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.216TMH02.64993-450o20-48i60-80o100-119i126-144o150-168iCytoplasmicMembrane109.02
YBJJ_ECOLIP75810
ybjJ
b0845 JW0829 Inner membrane protein ybjJIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN300.184TMH016.9774-12120i15-32o52-71i78-98o104-124i145-164o170-187i217-234o254-275i282-301o307-328i340-358o370-389iCytoplasmicMembrane10
YBJT_ECOLIP75822
ybjT
b0869 JW5116 Uncharacterized protein ybjTIntegral Inner Membrane BBoutout/inIM (predicted), Detected in IM FractionMembrane anchoredSRPSECyesyesN200.113CYT0-0.200913-110o446-464iCytoplasmicMembrane9.8218.63
YBJE_ECOLIP75826
ybjE
b0874 JW0858 Uncharacterized protein ybjENo TMH predictionsIntegral Inner Membrane BBpolyout/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.234TMH05.36895-890o6-23i35-55o61-83i104-129o135-155i167-188o208-228i249-267o279-297iCytoplasmicMembrane10
MACB_ECOLIP75831
macB

ybjZ

ybjZb0879 JW0863 Macrolide export ATP-binding/permease protein macB (EC 3.6.3.-)Cell inner membrane Cell inner membraneThe crystal structure of MacA has been determined at 3.0A resolution. The inner membrane transporter MacB requires the outer membrane factor TolC and the periplasmic adaptor protein MacA to form a functional tripartite complex. Electron microscopic indicates that the MacA hexamer interacts with TolCIn a tip-to-tip manner.PMID: 19254725 PMID: 21325274 PMID: 11544226 PMID: 17214741Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN340.136CYT0-0.200913-440i273-293o523-548i572-602o608-631iCytoplasmicMembrane1017.13
YCAM_ECOLIP75835
ycaM
b0899 JW5119 Inner membrane transporter ycaMIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN350.133TMH012.317-12120i12-30o42-63i84-102o126-146i153-176o196-218i239-261o293-312i344-364o384-402i414-435o447-470iCytoplasmicMembrane10
SSUC_ECOLIP75851
ssuC

ycbM

ycbMb0934 JW5121 Putative aliphatic sulfonates transport permease protein ssuCIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN240.119TMH120770i12-34o69-92i104-122o128-147i168-185o191-211i223-245oCytoplasmicMembrane106.51
YCCS_ECOLIP75870
yccS
b0960 JW5128 Inner membrane protein yccSIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN360.115TMH06.42867-9120i15-34o40-57i64-81o87-105i112-133o139-161i389-410o416-433i440-459o465-482i487-503o509-531iCytoplasmicMembrane10
RUTG_ECOLIP75892
rutG

ycdG

ycdGb1006 JW5137 Putative pyrimidine permease rutG (Pyrimidine utilization protein G)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN430.115CYT0-0.200913-11120i33-54o60-76i83-103o109-129i141-161o173-190i197-219o239-261i281-299o319-338i350-373o385-418iCytoplasmicMembrane10
EFEU_ECOLIP75901
efeU

ycdN

ycdNb4490 JW5141/JW1002 b1016/b1017Putative ferrous iron permease efeU (Putative Fe(2+) ion permease efeU)Integral Inner Membrane BBpolyout/inIM (predicted)CytoplasmicSRPSECpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoN160.112CYT0-0.200913-670o6-26i38-58o70-90i117-142o148-171i183-203o248-265iCytoplasmicMembrane10
PGAC_ECOLIP75905
pgaC

ycdQ

ycdQb1022 JW1007 Poly-beta-1,6-N-acetyl-D-glucosamine synthase (PGA synthase) (Poly-beta-1,6-GlcNAc synthase) (EC 2.4.1.-) (Biofilm PGA synthesis protein PgaC) (N-acetylglucosaminyltransferase PgaC)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN230.19TMH017.09-54Yn6-17c22/23o32-54i323-345o365-383i395-417oCytoplasmicMembrane1017.65
YCDT_ECOLIP75908
ycdT
b1025 JW5143 Probable diguanylate cyclase YcdT (DGC) (EC 2.7.7.65)Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.126TMH010.4982-880i12-29o41-67i79-99o114-131i151-169o189-213i220-241o261-278iCytoplasmicMembrane10
YCDU_ECOLIP75910
ycdU
b1029 JW1015 Uncharacterized protein yrbNIntegral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN360.12TMH07.11263-880i16-32o44-68i89-114o120-141i162-182o202-222i255-277o289-309iCytoplasmicMembrane10
OPGC_ECOLIP75920
mdoC

opgC ymdD

opgC ymdDb1047 JW1034 Glucans biosynthesis protein C (EC 2.1.-.-)Integral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.12TMH012.3178-10100i17-38o58-80i92-113o133-157i177-201o213-234i246-264o276-295i307-330o336-356iCytoplasmicMembrane10
C56I_ECOLIP75925
yceJ
b1057 JW1044 Cytochrome b561 homolog 2Integral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.121TMH013.644-440i12-35o55-72i92-111o144-164iCytoplasmicMembrane1010.58
YCFT_ECOLIP75955
ycfT
b1115 JW1101 Inner membrane protein ycfTIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.109TMH011.9971-880i12-32o52-70i90-113o133-156i163-183o195-212i224-256o310-331iCytoplasmicMembrane10
LOLE_ECOLIP75958
lolE

ycfW

ycfWb1118 JW1104 Lipoprotein-releasing system transmembrane protein lolEIntegral Membrane ProteinPMID: 17498646 PMID: 15276320 PMID: 10783239Integral Inner Membrane BBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN360.113TMH06.76692-440i21-48o270-293i314-341o380-399iCytoplasmicMembrane1020.39
YCFZ_ECOLIP75961
ycfZ
b1121 JW1107 Inner membrane protein ycfZIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN190.268SpI207.80323-43Yn4-14c19/20o183-201i208-230o242-259iCytoplasmicMembrane10
YCGG_ECOLIP75995
ycgG
b1168 JW5174 Uncharacterized protein YcgGIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)CytoplasmIntegral Membrane ProteinSECnoyesN330.194CYT0-0.200913-220o6-28i221-239oCytoplasmicMembrane7.88
CVRA_ECOLIP76007
cvrA

ycgO

ycgOb1191 JW5184 Cell volume regulation protein AIntegral Inner Membrane BBpolyout/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.165TMH09.70846-11130o6-23i30-47o59-76i88-113o119-141i162-179o191-210i217-237o243-261i273-292o298-323i335-357o363-381iCytoplasmicMembrane10
PUUP_ECOLIP76037
puuP

ycjJ

ycjJb1296 JW1289 Putrescine importerIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN430.116TMH02.35137-12120i24-47o59-77i98-120o132-150i162-182o202-221i241-264o291-319i340-359o365-386i398-417o423-442iCytoplasmicMembrane10
YNBB_ECOLIP76091
ynbB
b1409 JW1406 Uncharacterized protein ynbBIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/outIM (predicted), Detected in IM FractionCell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN600.122TMH08.47225-97Yn6-16c21/22o37-54i61-83o95-119i131-154o166-187i208-227o233-253iCytoplasmicMembrane10
YNBD_ECOLIP76093
ynbD
b1411 JW1408 Uncharacterized protein ynbDIntegral Inner Membrane BBpolyout/outIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN240.123TMH013.3648-88Yn4-15c33/34o49-72i84-105o125-141i153-170o176-193i213-236o242-261i273-292oCytoplasmicMembrane10
YDCO_ECOLIP76103
ydcO
b1433 JW5229 Inner membrane protein ydcOIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN270.198TMH015.9189-1012Yn10-20c25/26o41-63i70-88o94-114i119-138o144-161i168-187o207-224i236-254o260-276i288-313o319-337i349-382oCytoplasmicMembrane10
YNEF_ECOLIP76147
yneF
b1522 JW5825 Uncharacterized protein YneFIntegral inner membrane (experimental).PMID: 15919996Integral Inner Membrane BBpolyin/inIM (predicted)Cell membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)nonoN340.118TMH09.08181-440o12-29i41-68o80-102i114-135oCytoplasmicMembrane1031.6
YNFA_ECOLIP76169
ynfA
b1582 JW1574 UPF0060 membrane protein ynfACell inner membrane Integral inner membrane (experimental). Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996PMID: 11867724 PMID: 15919996 PMID: 24688744 PMID: 16429150Integral Inner Membrane BBpoly, Bmultiout/out, in/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN620.224TMH010.6101-440o6-26i33-54o60-78i85-105oCytoplasmicMembrane10
YNFH_ECOLIP76173
ynfH
b1590 JW5261 Anaerobic dimethyl sulfoxide reductase chain ynfH (DMSO reductase anchor subunit ynfH)Integral inner membrane (experimental). The ynfEFGHI operon is a paralogue of the Escherichia coli dmsABC operon. ynfE and ynfF are paralogues of dmsA. ynfG and ynfH are paralogues of dmsB and dmsC, respectively. ynfFGH are expressed anaerobically. So far, hydroxy pyridine N-oxide is the best substrate for YnfFGH. YnfH can function with DmsAB, replacing DmsC as the anchor subunit. The physiological substrate and relevance of the YnfFGH S- and N-oxide reductase is unknown.PMID: 14522592.PMID: 15919996 PMID: 14522592Integral Inner Membrane BBpolyout/outIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN340.15TMH013.2137-880o12-34i46-67o87-104i116-138o150-169i181-204o224-243i250-271oCytoplasmicMembrane10
CLCB_ECOLIP76175
clcB

mriT ynfJ

mriT ynfJb1592 JW5263 Voltage-gated ClC-type chloride channel ClcBNucleoid (experimental). Integral inner membrane (experimental).PMID: 23138451 PMID: 15919996Nucleoid, Integral Inner Membrane N, Bout/inIM (predicted)Cell inner membrane | Multi-pass membrane protein.Integral Membrane ProteinSRPSECyesyesN210.254TMH010.4168-109Yn5-16c21/22o54-71i144-162o174-200i221-241o261-282i294-313o319-338i350-372o384-404iCytoplasmicMembrane1039.23
RNFD_ECOLIP76182
rnfD

ydgO

ydgOb1630 JW1622 Electron transport complex protein rnfDIntegral Inner Membrane BBpolyin/inIM (predicted)Cell inner membrane | Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN340.191TMH05.44392-10100i20-38o44-62i69-89o95-113i125-143o210-235i242-262o268-287i299-318o324-342iCytoplasmicMembrane10
YDHJ_ECOLIP76185
ydhJ
b1644 JW1636 Uncharacterized protein ydhJIntegral Inner Membrane BBinout/inN/AMembrane | Single-pass membrane proteinMembrane anchoredSRPSECyesyesN690.119TMH04.39451-110o6-26iCytoplasmicMembrane9.82