entryaccgenealt_geneolnprotein_namecm_locacm_notescm_refssuboci_fullsublocisubloci_iimnterm_ctermbernselsubloci_uniprotsubloci_echoLorganelletarget_chaperoning11st_sstarget_chaperoning22nd_sspseudocommon_corebasic_proteomesignalp_sp_existsignalp_possignalp_cmaxlipop_predlipop_cleavagelipop_scorelipop_ruletmhmmphobius_tmsphobius_sp_existphobius_predictionpsortb_locapsortb_scoresolubility
YKFM_ECOLIA5A605
ykfM
b4586 integral IM protein (SEC in IM), YkfMIntegral Inner MembraneBBpolyin/outIM (predicted)Membrane -SRPSECnoyesN270.205TMH013.6098-33Ni12-32o52-75i96-119oCytoplasmicMembrane10
YNCL_ECOLIA5A615
yncL
b4598 JW1439.1 integral IM protein (SEC in IM), YncLIntegral Inner Membrane Small membrane protein detected experimentally. Found to co-fractionate with the inner membrane.PMID: 19121005 PMID: 21778229Integral Inner MembraneBBinoutin/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN270.099CYT0-0.200913-11Ni7-29oCytoplasmicMembrane9
YNEM_ECOLIA5A616
yneM
b4599 JW1527.1 integral IM protein (SEC in IM), Small MgtS Integral Inner Membrane Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(out)-C(in).PMID: 19121005 PMID: 21778229Integral Inner MembraneBBinoutin/outN/ACell inner membrane Integral Membrane ProteinSRPSECnoyesN240.123CYT0-0.200913-11Ni7-25oCytoplasmicMembrane9
YDGU_ECOLIA5A617
ydgU
b4601 JW1589 integral IM protein (SEC in IM), YdgUIntegral Inner Membrane Small membrane protein detected experimentally.PMID: 19121005Integral Inner MembraneBBinoutin/outIM (predicted)-SRPSECnoyesN270.097CYT0-0.200913-11Ni7-26oUnknown2
YNHF_ECOLIA5A618
ynhF
b4602 JW1649.1 integral IM protein (SEC in IM), YnhFIntegral Inner Membrane Found to co-fractionate with the inner membrane. Can be inserted in both orientations (Cout-Nin and Cin-Nout).PMID: 19121005 PMID: 21778229Integral Inner MembraneBBinoutin/out, out/inIM (predicted)Cell inner membrane -SRPSECnoyesN270.105CYT0-0.200913-11Ni7-28oCytoplasmicMembrane9
DINQ_ECOLIA5A624
dinQ
b4613 integral IM protein (SEC in IM), DinQIntegral Inner MembraneBBinoutin/outIM (predicted)Cell inner membrane -SRPSECnoyesN310.097CYT0-0.200913-11Ni20-38oUnknown2
TISB_ECOLIA5A627
tisB

ysdB

ysdBb4618 JW3649 integral IM protein (SEC in IM), Small toxin TisBIntegral Inner Membrane Potentially toxic protein.PMID: 19121005 PMID: 18761622Integral Inner MembraneBBinoutout/inIM (predicted)Cell inner membrane -SRPSECpseudogene (Uniprot), pseudogene (Ecogene)nonoN230.099CYT0-0.200913-11No6-25iUnknown2
YTCA_ECOLIA5A630
ytcA
b4622 integral IM protein (SEC in IM), YtcAIntegral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane ProteinSECnoyesN330.139TMH010.1309-22Yn16-27c32/33o42-61i68-90oCytoplasmicMembrane10
YTHA_ECOLIA8DYQ1
ythA
b4655 JW5769.1 integral IM protein (SEC in IM), YthAIntegral Inner Membrane Small membrane protein detected experimentallyPMID: 19121005Integral Inner MembraneBBinin/outN/ACell inner membrane -SECnoyesN410.12CYT0-0.200913-11Ni21-40oCytoplasmicMembrane9
YKGR_ECOLIC1P5Z8
ykgR
b4671 JW5035.1 integral IM protein (SEC in IM), YkgRIntegral Inner Membrane Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(in)-C(out).PMID: 19121005 PMID: 21778229Integral Inner MembraneBBinoutin/outN/ACell inner membrane -SRPSECnoyesN210.096CYT0-0.200913-11Ni12-30oUnknown2
YMIB_ECOLIC1P5Z9
ymiB
b4672 JW1278.1 integral IM protein (SEC in IM), Putative YmiBIntegral Inner MembraneBBinoutin/outN/AMembrane -SRPSECnoyesN280.1CYT0-0.200913-11Ni12-29oUnknown2
YOAK_ECOLIC1P602
yoaK
b4676 JW5292.1 integral IM protein (SEC-YidC in IM), YoaKIntegral Inner Membrane Found to co-fractionate with the inner membrane. Can be inserted in both orientations (Cout-Nin and Cin-Nout). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased.PMID: 19121005 PMID: 21778229Integral Inner MembraneBBinoutin/out, out/inN/ACell inner membrane -SRPSEC-YidCnoyesN290.152TMH03.55641-11No6-29iCytoplasmicMembrane9
YOAJ_ECOLIC1P603
yoaJ
b4675 JW5292.2 integral IM protein (SEC-YidC in IM), YoaJIntegral Inner Membrane Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(in)-C(out). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased.PMID: 19121005 PMID: 21778229Integral Inner MembraneBBinoutin/outN/ACell inner membrane -SRPSEC-YidCnoyesN190.098CYT0-0.200913-11No6-23iCytoplasmicMembrane9
YOHP_ECOLIC1P609
yohP
b4679 JW5358.1 integral IM protein (SEC in IM), YohPIntegral Inner Membrane Found to co-fractionate with the inner membrane. Can be inserted in both orientations (Cout-Nin and Cin-Nout).PMID: 19121005 PMID: 21778229Integral Inner MembraneBBinoutin/out, out/inN/ACell inner membrane -SRPSECnoyesN250.1TMH00.568556-11No6-26iCytoplasmicMembrane9
YPDK_ECOLIC1P610
ypdK
b4680 JW2375.1 integral IM protein (SEC in IM), YpdKIntegral Inner Membrane Found to co-fractionate with the inner membrane.PMID: 19121005 PMID: 21778229Integral Inner MembraneBBinoutout/inN/ACell inner membrane -SRPSECnoyesN170.106CYT0-0.200913-11No6-22iCytoplasmicMembrane9
SHOB_ECOLIC1P611
shoB

ryfB yphI

ryfB yphIb4687 JW2546.1 integral IM protein (SEC in IM), Small toxin ShoBIntegral Inner Membrane PMID: 19121005 PMID: 18710431Integral Inner MembraneBBinoutin/outN/AMembrane -SRPSECnoyesN130.098CYT0-0.200913-11Ni7-25oCytoplasmicMembrane9
YQFG_ECOLIC1P614
yqfG
b4684 JW5470.1 integral IM protein (SEC in IM), YqfGIntegral Inner Membrane Small protein detected experimentally.PMID: 19121005Integral Inner MembraneB-N/A-SRPSECnoyesN240.133TMH02.01664-10Yn7-17c29/30oCytoplasmicMembrane9
IBSD_ECOLIC1P616
ibsD
b4664 JW3023.1 integral IM protein (SEC in IM), Small toxin IbsDIntegral Inner Membrane Belongs to the toxic protein ibs family. Potentially toxic protein.PMID: 19121005Integral Inner MembraneB-N/AMembrane -SECnoyesN180.098CYT0-0.200913-10Yn4-9c13/14oCytoplasmicMembrane9
PMRR_ECOLIG3MTW7
pmrR
b4703 JW4072.1integral IM protein (SEC in IM), Putative PmrR Integral Inner MembraneBBoutin/outN/ACell inner membrane -SECnoN0.098CYT0-0.200913-11Ni9-26oUnknown2
PHSM_ECOLIP00490
malP
b3417 JW5689 integral IM protein (SEC in IM), Maltodextrin phosphorylase MalPIntegral Inner Membrane PMID: 15919657Integral Inner MembraneB-Soluble IM FractionCytoplasmicSECyesyesN540.131CYT0-0.200913-00NiCytoplasmic9
PTM3C_ECOLIP00550
mtlA
b3599 JW3573 integral IM protein (SEC in IM), PTS system mannitol-specific EIICBA component MtlAIntegral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. The signal anchor sequence of MtlA confers novel properties onto nascent chains of OmpA of being co-translationally recognized and targeted to SecY by SRP. PMCID: PMC305875 The signal anchor sequence of MtlA confers novel properties onto nascent chains of OmpA of being co-translationally recognized and targeted to SecY by SRP. Once targeted to SecY, ribosome-associated nascent chains of the hybrid protein, however, remain untranslocated unless SecA is present. These results indicate that SRP and SecA cooperate in a sequential, non-overlapping manner. PMCID: PMC305875PMID: 9008159 PMID: 15919657 PMID: 15919996 PMID: 9260961 PMCID: PMC305875Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRP (exp)SECyesyesN230.115TMH011.9934-88Ni20-42o48-66i78-98o133-154i161-181o213-234i269-292o312-334iCytoplasmicMembrane1026
LEP_ECOLIP00803
lepB
b2568 JW2552 integral IM protein (SEC-YidC in IM), Signal peptidase I LepBIntegral Inner Membrane Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased. Lep was shown to be targeted to the membrane by the SRP pathway. PMID: 8985168 Disulfide bridge (171 177) PMID: 2551889 PMID: 21778229 PMID: 15919996 PMID: 8985168 Integral Inner MembraneBout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSEC-YidCyesyesN220.131SpII203.04951Pos+2=V20Yn5-16c21/22oCytoplasmicMembrane1027
LSPA_ECOLIP00804
lspA

lsp

lspb0027 JW0025 integral IM protein (SEC in IM), Signal peptidase II LspAIntegral Inner Membrane Catalyzes the removal of signal peptides from prolipoproteins.PMID: 6378662 PMID: 6368552 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN360.135TMH07.83163-44Ni12-31o70-88i100-117o137-157iCytoplasmicMembrane105
MALF_ECOLIP02916
malF
b4033 JW3993 integral IM protein (SEC in IM), Maltose/maltodextrin transport system permease MalF Integral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. MalF functions in maltose transport as a 1:1:2 complex with the integral inner membrane protein MalG and the peripheral inner membrane protein MalK. Crystal structure of a catalytic intermediate of the maltose transporter. PMID: 18033289 Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 9008159 PMID: 18456666 PMID: 15919996 PMID: 18033289 PMID: 25403562Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRP (exp)SECYfgMnoyesN650.175TMH014.2023-88Ni14-34o40-58i67-91o277-303i315-340o371-392i426-447o484-506iCytoplasmicMembrane10
PBPA_ECOLIP02918
mrcA

ponA

ponAb3396 JW3359 integral IM protein (SEC in IM), Penicillin-binding 1A MrcAIntegral Inner Membrane The formation of a complex between a murein polymerase (PBP1B) and a murein hydrolase (MltA) in the presence of MipA represents a first step in a reconstitution of the hypothetical murein-synthesizing holoenzyme, postulated to be responsible for controlled growth of the stress-bearing sacculus of E. coli. The two OM lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase activity, thereby facilitating attachment of new peptidoglycans to the PG sacculus. Uniprot annotation is Cell inner membrane; Single-pass type II membrane protein, Gene Ontology and Echolocation annotation is Membrane anchored. PMID: 3510188PMID: 10037771 PMID: 21183073 PMID: 15919657 PMID: 3510188Integral Inner MembraneBBoutin/outSoluble IM FractionCell inner membrane Membrane anchored (Experimental)SRPSECyesyesN250.144TMH02.26474-10Yn7-17c24/25oCytoplasmicMembrane104
GSPB_ECOLIP03825
gspB

pinO pioO pno

pinO pioO pnob3322 JW3284 integral IM protein (SEC in IM), Putative general secretion pathway B GspBIntegral Inner MembraneBBinout/inIM (predicted)Cell membrane Membrane anchoredSRPSECnoyesN430.123TMH03.27755-11No28-51iUnknown2
PBPB_ECOLIP02919
mrcB

pbpF ponB

pbpF ponBb0149 JW0145 integral IM protein (SEC in IM), Penicillin-binding 1B MrcBIntegral Inner Membrane The two OM lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase activity, thereby facilitating attachment of new peptidoglycans to the PG sacculus. Cell inner membrane; Single-pass type II membrane protein. Monoisotopic peripheral; Contains amphipathic a-helix.PMID: 19458048 PMID: 21183073 PMID: 15919657Integral Inner MembraneBBoutin/outIM (predicted), Detected in IM FractionCell inner membrane; Single-pass type II membrane proteinMembrane anchoredSRPSECyesyesN30.105CYT0-0.200913-11Ni65-86oCytoplasmicMembrane10
LACY_ECOLIP02920
lacY
b0343 JW0334 integral IM protein (SEC in IM), Lactose permease LacYIntegral Inner Membrane Crystal structure of lactose permease indicated that the molecule is composed of N- and C-terminal domains, each with six transmembrane helices, symmetrically positioned within the permease PMID: 12893935.PMID: 11266632 PMID: 12893935 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN260.125TMH018.848-1112Ni12-34o46-66i75-95o101-122i143-162o168-187i222-239o259-279i291-310o316-337i349-369o381-401iCytoplasmicMembrane10
MELB_ECOLIP02921
melB

mel-4

mel-4b4120 JW4081 integral IM protein (SEC in IM), Melibiose carrier MelBIntegral Inner Membrane PMID: 7703254 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN180.118TMH08.17946-1212Ni12-31o37-57i78-100o106-130i150-171o177-198i236-258o270-290i297-318o324-353i374-397o409-432iCytoplasmicMembrane10
PPDB_ECOLIP08371
ppdB

ygdC

ygdCb2825 JW5451 integral IM protein (SEC in IM), Prepilin peptidase-dependent B PpdBIntegral Inner MembraneBBinout/inIM (predicted)Membrane anchoredSRPSECyesyesN360.136CYT0-0.200913-11No13-34iUnknown223
PPDC_ECOLIP08372
ppdC

ygdA

ygdAb2823 JW2791 integral IM protein (SEC in IM), Prepilin peptidase-dependent C PpdCIntegral Inner MembraneBBinout/inIM (predicted)Membrane anchoredSRPSECyesyesN300.122TMH06.3414-11No16-33iUnknown224
FTSB_ECOLIP0A6S5
ftsB

ygbQ

ygbQb2748 JW2718 integral IM protein (SEC in IM), Cell division FtsBIntegral Inner Membrane PMID: 11972052 PMID: 15165235Integral Inner MembraneBBoutout/inIM (predicted)Cell inner membrane Membrane anchoredSRPSECyesyesN230.157CYT0-0.200913-10Yn4-14c18/19oCytoplasmicMembrane925
TONB_ECOLIP02929
tonB

exbA

exbAb1252 JW5195 integral IM protein (SEC in IM), TonBIntegral Inner Membrane PMID: 11967085Integral Inner MembraneBBoutin/outN/ACell inner membrane; Single-pass membrane protein; Periplasmic sideMembrane anchoredSECyesyesN430.176TMH03.06055-01Ni12-32oUnknown2
MCP1_ECOLIP02942
tsr

cheD

cheDb4355 JW4318 integral IM protein (SEC in IM), Methyl-accepting chemotaxis I TsrIntegral Inner Membrane PMID: 22380631 PMID: 15919996Integral Inner MembraneBBinoutout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECnoyesN310.141SpI255.90497-21Yn10-21c26/27o192-214iCytoplasmicMembrane1044
KEFC_ECOLIP03819
kefC

trkC

trkCb0047 JW0046 integral IM protein (SEC in IM), Glutathione-regulated potassium-efflux system KefC Integral Inner Membrane PMID: 2046548 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN340.112TMH07.67646-1313No6-24i31-49o55-72i84-111o117-135i147-169o181-202i214-233o239-258i270-290o296-315i327-348o360-378iCytoplasmicMembrane10
KDPA_ECOLIP03959
kdpA
b0698 JW0686 integral IM protein (SEC in IM), Potassium-transporting ATPase potassium-binding subunit KdpAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN210.183TMH00.239367-1212Yn5-16c20/21o59-82i94-115o135-155i167-190o253-271i283-301o327-349i356-374o380-398i418-437o484-505i526-548oCytoplasmicMembrane1010
PSIE_ECOLIP0A7C8
psiE

yjbA

yjbAb4030 JW3990 integral IM protein (SEC in IM), PsiEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN430.143TMH04.00332-44Ni12-35o55-74i86-105o111-128iCytoplasmicMembrane10
YFBV_ECOLIP0A8D9
yfbV
b2295 JW2292 integral IM protein (SEC in IM), UPF0208 YfbVIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN230.122CYT0-0.200913-22Ni46-64o70-90iCytoplasmicMembrane1038
USPB_ECOLIP0A8S5
uspB

yhiO

yhiOb3494 JW3461 integral IM protein (SEC in IM), Universal stress B UspBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.13TMH00.843073-22No6-24i90-110oCytoplasmicMembrane1057
KDPB_ECOLIP03960
kdpB
b0697 JW0685 integral IM protein (SEC in IM), Potassium-transporting ATPase ATP-binding subunit KdpBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN550.195CYT0-0.200913-76Ni35-56o62-82i219-240o252-274i616-636o656-681iCytoplasmicMembrane108
KDPC_ECOLIP03961
kdpC
b0696 JW0684 integral IM protein (SEC in IM), Potassium-transporting ATPase KdpC subunit KdpCIntegral Inner MembraneBBoutin/outN/ACell inner membrane Membrane anchoredSRPSECnoyesN390.2TMH011.3621-10Yn7-18c30/31oCytoplasmicMembrane1018
MCP3_ECOLIP05704
trg
b1421 JW1417 integral IM protein (SEC in IM), Methyl-accepting chemotaxis III TrgIntegral Inner Membrane PMID: 22380631 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECnoyesN400.259TMH07.8524-22Ni20-44o199-222iCytoplasmicMembrane1034
FTSQ_ECOLIP06136
ftsQ
b0093 JW0091 integral IM protein (SEC in IM), Cell division FtsQIntegral Inner Membrane FtsQ could be localized to the division site in constricting cells. FtsQ insertion requires SecYEG, the transmembrane electrical potential, SecA, and the SRP pathway. PMID: 15546656 YidC plays a role in the membrane integration of the FtsQ protein as the hydrophobic region of FtsQ can be cross-linked to YidC. PMID: 15546656PMID: 2007547 PMID: 9829918 PMID: 9882666 PMID: 11415986 PMID: 11703663 PMID: 11948172 PMID: 15165235 PMID: 17693520 PMID: 15546656Integral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane Membrane anchoredSRPSECyesyesN410.115TMH01.18618-11Ni25-49oUnknown224
ESSD_ECOLIP0A9R2
essD

ybcR

ybcRb0554 JW0543 integral IM protein (SEC in IM), Prophage lysis S homolog EssD Integral Inner MembraneBBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)yesnoN380.193CYT0-0.200913-22Ni7-25o37-58iUnknown214
YMCE_ECOLIP0AAA5
ymcE

sfa

sfab0991 JW0975 integral IM protein (SEC in IM), YmcEIntegral Inner MembraneBBoutin/outN/ACell membrane Membrane anchoredSRPSECnoyesN460.141TMH04.44945-10Yn15-25c29/30oUnknown2100
YAIY_ECOLIP0AAP7
yaiY
b0379 JW0370 integral IM protein (SEC in IM), YaiYIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.177TMH0-0.122448-22Ni25-48o68-95iCytoplasmicMembrane1039
BTUC_ECOLIP06609
btuC
b1711 JW1701 integral IM protein (SEC-YidC in IM), Vitamin B12 import system permease BtuC Integral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 11266632 PMID: 12004122 PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN340.278TMH013.5896-99Yn16-29c34/35o58-77i89-109o115-133i145-168o188-206i213-232o238-262i274-297o303-322iCytoplasmicMembrane10
BIRA_ECOLIP06709
birA

bioR dhbB

bioR dhbBb3973 JW3941 nucleoid & integral IM protein (SEC in IM), Bifunctional ligase/repressor BirAIntegral Inner Membrane, NucleoidPMID: 23138451 PMID: 23387333Integral Inner Membrane, NucleoidB, NIM (predicted)CytoplasmicSRPSECyesyesN260.122CYT0-0.200913-02Ni123-139o145-162iCytoplasmic1037
FHUB_ECOLIP06972
fhuB
b0153 JW0149 integral IM protein (SEC in IM), Iron(3+)-hydroxamate import system permease FhuBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN320.415TMH012.8147-1717Yn5-20c38/39o62-79i91-111o117-137i144-167o194-212i224-241o247-265i277-299o305-326i347-369o389-411i423-443o449-468i480-499o567-594i606-623o635-655iCytoplasmicMembrane10
PNTA_ECOLIP07001
pntA
b1603 JW1595 integral IM protein (SEC in IM), PntAIntegral Inner Membrane PMID: 14660605 PMID: 15919996 PMID: 3525165 PMID: 1932078Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN400.111CYT0-0.200913-54Ni400-418o424-443i455-472o478-499iCytoplasmicMembrane10110
YAIZ_ECOLIP0AAQ0
yaiZ
b0380 JW5053 integral IM protein (SEC in IM), YaiZIntegral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN180.115TMH06.70305-22Ni12-32o38-59iCytoplasmicMembrane972
YBAN_ECOLIP0AAR5
ybaN
b0468 JW0457 integral IM protein (SEC in IM), YbaNIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN490.172TMH011.6864-44Ni5-25o31-52i73-91o97-115iCytoplasmicMembrane1015
MCP2_ECOLIP07017
tar

cheM

cheMb1886 JW1875 integral IM protein (SEC in IM), Methyl-accepting chemotaxis II TarIntegral Inner Membrane Pole-derived membrane fragments were isolated by affinity capture of vesicles containing the chemotaxis protein, Tar. PMID: 3049536 PMID: 12826616 PMID: 17144658PMID: 22380631 PMID: 15919996 PMID: 3049536 PMID: 12826616 PMID: 17144658Integral Inner MembraneBBinoutout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN200.158TMH04.99054-21Yn10-21c26/27o192-212iCytoplasmicMembrane1073
MCP4_ECOLIP07018
tap
b1885 JW1874 integral IM protein (SEC in IM), Methyl-accepting chemotaxis IV TapIntegral Inner Membrane PMID: 22380631 PMID: 15919996Integral Inner MembraneBBinoutout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECnoyesN350.179TMH06.20402-21Yn10-21c34/35o187-209iCytoplasmicMembrane105
PUTP_ECOLIP07117
putP
b1015 JW1001 integral IM protein (SEC in IM), Sodium/proline symporter PutPIntegral Inner Membrane PMID: 16079137 PMID: 15919996 PMID: 3302614Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN280.128TMH013.7134-1212Ni7-26o66-88i127-152o164-186i193-213o233-256i277-296o325-350i371-391o403-422i429-449o455-473iCytoplasmicMembrane10
PSTA_ECOLIP07654
pstA

phoT

phoTb3726 JW3704 integral IM protein (SEC in IM), Phosphate transport system permease PstA Integral Inner Membrane PMID: 3881386 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN140.135TMH014.9057-66Ni29-50o89-111i123-145o151-169i201-222o267-290iCytoplasmicMembrane10
YLAC_ECOLIP0AAS0
ylaC
b0458 JW5063 integral IM protein (SEC in IM), YlaCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN510.106CYT0-0.200913-22Ni36-55o61-79iCytoplasmicMembrane1060
YBFA_ECOLIP0AAU2
ybfA
b0699 JW0688 integral IM protein (SEC in IM), YbfAIntegral Inner MembraneBBinout/inIM (predicted)Membrane anchoredSRPSECnoyesN220.331TMH02.48449-11No12-33iCytoplasmicMembrane912
YBFB_ECOLIP0AAU5
ybfB
b0702 JW0691 integral IM protein (SEC in IM), YbfBIntegral Inner MembraneBBpolyout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN290.135TMH015.1783-33No6-24i45-68o80-101iCytoplasmicMembrane1035
GLPT_ECOLIP08194
glpT
b2240 JW2234 integral IM protein (SEC in IM), Glycerol-3-phosphate transporter GlpTIntegral Inner Membrane PMID: 11266632 PMID: 12893935 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN520.128CYT0-0.200913-1212Ni26-44o64-82i94-113o119-138i159-183o189-208i254-272o292-311i323-342o348-373i385-405o417-437iCytoplasmicMembrane10
CRED_ECOLIP08369
creD

cet

cetb4400 JW4363 integral IM protein (SEC-YidC in IM), CreDIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCnoyesN290.114TMH04.58166-65Yn11-22c34/35o295-313i325-343o349-368i375-396o402-420iCytoplasmicMembrane1028
SPPA_ECOLIP08395
sppA
b1766 JW1755 integral IM protein (SEC in IM), Protease 4 SppAIntegral Inner Membrane PMID: 3522590 PMID: 18476724Integral Inner MembraneBBoutin/outIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN480.115TMH06.31524-11Ni21-43oCytoplasmicMembrane1014
PHOR_ECOLIP08400
phoR

nmpB

nmpBb0400 JW0390 integral IM protein (SEC in IM), Phosphate regulon sensor PhoR PhoRIntegral Inner Membrane PMID: 2187152 PMID: 15919996Integral Inner MembraneBBpolyin/inN/ACell inner membrane Membrane anchoredSRPSECyesyesN240.17TMH020.4877-12Ni12-36o42-59iCytoplasmicMembrane1013
YBGE_ECOLIP0AAV0
ybgE
b0735 JW0725 integral IM protein (SEC in IM), YbgEIntegral Inner MembraneBBpolyout/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN410.437TMH03.17076-33No17-34i46-67o73-96iCytoplasmicMembrane1027
YBHQ_ECOLIP0AAW5
ybhQ
b0791 JW0774 integral IM protein (SEC in IM), YbhQIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.117TMH07.89577-44Ni12-32o38-58i79-96o102-120iCytoplasmicMembrane10
YBJO_ECOLIP0AAZ0
ybjO
b0858 JW0842 integral IM protein (SEC in IM), YbjOIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN180.159TMH04.12536-44Ni21-44o64-87i94-111o131-151iCytoplasmicMembrane1032
CREC_ECOLIP08401
creC

phoM

phoMb4399 JW4362 integral IM protein (SEC-YidC in IM), Sensor CreCIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBinoutout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN250.159SpI27-0.123855-21Yn7-18c24/25o184-206iCytoplasmicMembrane1016
CVPA_ECOLIP08550
cvpA

dedE

dedEb2313 JW2310 integral IM protein (SEC in IM), Colicin V production CvpAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN310.117TMH06.39839-44No6-25i32-52o64-87i99-120oCytoplasmicMembrane10
DSDX_ECOLIP08555
dsdX

orf445 yfdA yfdD

orf445 yfdA yfdDb2365 JW2362 integral IM protein (SEC in IM), D-serine transporter DsdXIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECnoyesN330.118TMH011.5143-1212No6-23i30-47o59-77i98-128o140-158i178-198o225-244i256-282o302-322i343-365o385-408i420-444oCytoplasmicMembrane1012
PTV3B_ECOLIP08722
bglF

bglC bglS

bglC bglSb3722 JW3700 integral IM protein (SEC in IM), PTS system beta-glucoside-specific EIIBCA component BglFIntegral Inner Membrane In the absence of ??-glucosidase, associates with BglG to form a pro-form membrane complex that maintains BglG inactive.PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN410.16CYT0-0.200913-1012Ni100-121o141-160i172-190o210-230i242-263o269-292i299-322o328-347i354-375o381-400i407-424o430-452iCytoplasmicMembrane10
YCFJ_ECOLIP0AB35
ycfJ
b1110 JW1096 integral IM protein (SEC in IM), YcfJIntegral Inner MembraneB-N/AMembrane Membrane anchoredSRPSECyesyesN360.275SpI238.09735-10Yn6-17c21/22oUnknown2
YCHH_ECOLIP0AB49
ychH
b1205 JW1196 integral IM protein (SEC in IM), YchHIntegral Inner MembraneBBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN440.123TMH012.8445-22Ni12-29o41-59iCytoplasmicMembrane973
MRED_ECOLIP0ABH4
mreD
b3249 JW3218 integral IM protein (SEC in IM), Rod shape-determining MreD Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.118TMH015.556-55No6-25i37-54o74-92i104-128o134-152iCytoplasmicMembrane10
HEMX_ECOLIP09127
hemX
b3803 JW3775 integral IM protein (SEC in IM), HemXIntegral Inner Membrane PMID: 16079137Integral Inner MembraneBBoutin/outIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECnoyesN500.207CYT0-0.200913-11Ni36-57oCytoplasmicMembrane10
PTW3C_ECOLIP09323
nagE

pstN

pstNb0679 JW0665 integral IM protein (SEC in IM), PTS system N-acetylglucosamine-specific EIICBA component NagEIntegral Inner Membrane PMID: 15919657 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN450.132TMH03.42438-1012Ni12-32o38-61i68-88o94-112i132-153o165-185i192-212o232-252i259-276o282-306i313-331o337-359iCytoplasmicMembrane101
MOTA_ECOLIP09348
motA

flaJ

flaJb1890 JW1879 integral IM protein (SEC in IM), Motility A MotAIntegral Inner Membrane Interacts with flagellar brake protein YcgR in the flagellar basal bodies or FliM or FliG.PMID: 20303158 PMID: 20346719 PMID: 19364805 PMID: 23193105 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.167TMH04.42407-44Yn2-11c16/17o32-49i70-87o171-189i201-220oCytoplasmicMembrane1018
GLPG_ECOLIP09391
glpG
b3424 JW5687 integral IM protein (SEC in IM), Rhomboid protease GlpG Integral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 11266632 PMID: 17051161 PMID: 16216077 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRP (exp)SECyesyesN160.202CYT0-0.200913-66Ni96-115o135-160i172-188o194-212i224-242o248-267iCytoplasmicMembrane10
CCMD_ECOLIP0ABM5
ccmD

yojM

yojMb2198 JW2186 integral IM protein (SEC in IM), Heme exporter D CcmDIntegral Inner MembraneBBinoutout/inIM (predicted)Cell inner membrane Membrane anchoredSRPSECnoyesN70.153TMH03.24028-11No12-37iCytoplasmicMembrane966
EXBD_ECOLIP0ABV2
exbD
b3005 JW2973 integral IM protein (SEC in IM), Biopolymer transport ExbDIntegral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane; Single-pass type II membrane proteinMembrane anchoredSRPSECyesyesN420.15TMH00.162291-11No20-41iCytoplasmicMembrane947
TOLR_ECOLIP0ABV6
tolR
b0738 JW0728 integral IM protein (SEC in IM), Tol-Pal system TolR Integral Inner Membrane PMID: 7744737Integral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane Membrane anchored (Experimental)SRPSECyesyesN370.197TMH00.527259-11Ni21-39oCytoplasmicMembrane923
DEDD_ECOLIP09549
dedD
b2314 JW5378 integral IM protein (SEC in IM), Cell division DedDIntegral Inner MembraneBBoutin/outIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN300.117SpI270.354359-11Ni9-27oUnknown2
UHPB_ECOLIP09835
uhpB
b3668 JW3643 integral IM protein (SEC in IM), Signal transduction histidine-kinase/phosphatase UhpB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN210.141TMH016.0266-79No6-28i40-60o80-100i112-132o138-162i183-201o207-224i231-249o255-273iCytoplasmicMembrane1019
UHPC_ECOLIP09836
uhpC
b3667 JW3642 integral IM protein (SEC in IM), sensor UhpC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN520.143CYT0-0.200913-1212Ni26-45o65-84i96-114o120-143i155-179o185-203i245-265o285-308i320-338o344-365i377-401o407-431iCytoplasmicMembrane10
UBIB_ECOLIP0A6A0
ubiB

aarF yigQ yigR yigS

aarF yigQ yigR yigSb3835 JW3812 integral IM protein (SEC in IM), Probable kinase UbiB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN500.114CYT0-0.200913-22Ni501-518o524-542iCytoplasmicMembrane1017
FLIL_ECOLIP0ABX8
fliL

cheC1 fla AI fla QI

cheC1 fla AI fla QIb1944 JW1928 integral IM protein (SEC in IM), FliLIntegral Inner MembraneBBoutin/outSoluble IM FractionCell inner membrane Outer membrane LipoproteinSRPSECnoyesN430.268SpII2610.5269Pos+2=A11Ni14-35oCytoplasmicMembrane1035
FLIQ_ECOLIP0AC07
fliQ

flaQ

flaQb1949 JW1933 Flagellar integral IM protein (SEC in IM), biosynthetic FliQIntegral Inner MembraneBBinoutin/inIM (predicted)Cell inner membrane Integral Membrane ProteinflagellumSRPSECnoyesN410.283TMH014.373-21Yn16-35c40/41o56-74iCytoplasmicMembrane1030
YEAL_ECOLIP0ACY6
yeaL
b1789 JW1778 integral IM protein (SEC in IM), UPF0756 YeaLIntegral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN250.203TMH08.39191-44Yn4-12c16/17o26-46i53-71o83-100i112-145oCytoplasmicMembrane10
YOHC_ECOLIP0AD17
yohC
b2135 JW5356 integral IM protein (SEC in IM), YohCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN450.135TMH02.03436-55Ni33-53o65-91i103-122o128-149i170-190oCytoplasmicMembrane1016
CLSA_ECOLIP0A6H8
clsA

cls nov yciJ

cls nov yciJb1249 JW1241 integral IM protein (SEC in IM), Cardiolipin synthase A ClsAIntegral Inner Membrane In E. coli, the cls and ybhO genes (renamed clsA and clsB, respectively) each encode a CL (cardiolipin) synthase (Cls) that catalyzes the condensation of two PG molecules to form CL and glycerol. PMID: 22988102PMID: 15919996 PMID: 22988102Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN220.149TMH05.41966-22No6-25i37-58oCytoplasmicMembrane103
CYSZ_ECOLIP0A6J3
cysZ
b2413 JW2406 integral IM protein (SEC-YidC in IM), Sulfate transporter CysZ Integral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC. PMID: 15919996PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPSEC-YidCyesyesN180.111TMH05.82324-45Ni31-51o71-92i143-163o169-188i209-242oCytoplasmicMembrane1019
DSBB_ECOLIP0A6M2
dsbB

roxB ycgA

roxB ycgAb1185 JW5182 integral IM protein (SEC-YidC in IM), Disulfide bond formation B DsbBIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC PMID: 22108384. The crystal structure revealed a transmembrane (TM) four-helix-bundle structure of DsbBPMID: 18406599. DsbB oxidizes the periplasmic protein DsbA, which in turn oxidizes the cysteines in other periplasmic proteins to make disulfide bondsPMID: 8430071. Gene fusion approaches were used to show that (i) DsbB is a membrane protein which spans the membrane four times and (ii) both the N- and C-termini of the protein are in the cytoplasmPMID: 7957076. The structure of DsbB revealed four transmembrane helices and one short horizontal helix juxtaposed with Cys130 in the mobile periplasmic loopPMID: 17110337. Disulfide bridge (41 44;104 130) PMID: 10064586PMID: 18406599 PMID: 11266632 PMID: 17110337 PMID: 22108384 PMID: 8430071 PMID: 7957076 PMID: 15919996 PMID: 10064586Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN250.286TMH04.8983-44Ni12-33o45-64i71-89o145-166iCytoplasmicMembrane1015
MRAY_ECOLIP0A6W3
mraY

murX

murXb0087 JW0085 integral IM protein (SEC in IM), Phospho-N-acetylmuramoyl-pentapeptide-transferase MraYIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN460.151CYT0-0.200913-1010No20-40i73-90o96-114i134-152o172-193i200-219o239-256i263-284o290-311i338-357oCytoplasmicMembrane10
YPHA_ECOLIP0AD47
yphA
b2543 JW2527 integral IM protein (SEC in IM), YphAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN580.13TMH013.6817-44Ni12-33o53-74i81-100o120-137iCytoplasmicMembrane10
YJJB_ECOLIP0ADD2
yjjB
b4363 JW4327 integral IM protein (SEC in IM), UPF0442 YjjBIntegral Inner MembraneBBpolyout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN260.153TMH07.02974-35No6-27i34-52o58-75i87-109o129-151iCytoplasmicMembrane1011
YHHN_ECOLIP0ADI9
yhhN
b3468 JW3433 integral IM protein (SEC in IM), YhhNIntegral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN190.165TMH07.64349-66Yn3-14c18/19o34-64i76-96o102-123i130-152o158-177i189-207oCytoplasmicMembrane10
YCIB_ECOLIP0A710
yciB

ispZ

ispZb1254 JW1246 integral IM protein (SEC in IM), Probable intracellular septation A YciBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.173TMH07.58982-55No20-39i51-68o74-96i117-139o151-170iCytoplasmicMembrane10
KDGT_ECOLIP0A712
kdgT
b3909 JW5560 integral IM protein (SEC in IM), 2-keto-3-deoxygluconate permease KdgTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN670.134TMH012.8678-1010Ni12-29o35-57i78-97o103-127i139-164o170-187i194-211o223-243i255-274o286-309iCytoplasmicMembrane10
MSCL_ECOLIP0A742
mscL

yhdC

yhdCb3291 JW3252 integral IM protein (YidC in IM), Large-conductance mechanosensitive channel MscLIntegral Inner Membrane PMID: 17113597 PMID: 22108384 PMID: 8890153 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPYidCyesyesN390.143CYT0-0.200913-22Ni21-52o72-96iCytoplasmicMembrane1066
RSXA_ECOLIP0A766
rsxA

rnfA ydgL

rnfA ydgLb1627 JW1619 integral IM protein (SEC in IM), Ion-translocating oxidoreductase complex subunit A RsxAIntegral Inner Membrane PMID: 15919996 PMID: 24688744Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane Protein(experimental)SRPSECyesyesN210.118TMH07.31415-66No6-26i38-59o65-87i99-122o134-155i167-191oCytoplasmicMembrane10
MNTH_ECOLIP0A769
mntH

yfeP

yfePb2392 JW2388 integral IM protein (SEC in IM), Divalent metal cation transporter MntHIntegral Inner Membrane PMID: 14607838 PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN280.129TMH09.54648-1111Ni21-40o52-75i95-116o122-144i156-176o196-216i237-263o283-313i325-343o349-370i391-410oCytoplasmicMembrane10
BCSF_ECOLIP0ADJ5
bcsF

yhjT

yhjTb3537 JW5663 integral IM protein (SEC in IM), Cellulose biosynthesis BcsFIntegral Inner MembraneBBinout/inIM (predicted)Cell inner membrane Membrane anchoredSRPSECnoyesN260.211CYT0-0.200913-11No6-25iUnknown268
YIAA_ECOLIP0ADJ8
yiaA
b3562 JW3534 integral IM protein (SEC in IM), YiaAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN220.118TMH07.26426-44Ni12-30o42-62i74-94o106-125iCytoplasmicMembrane1059
YIAW_ECOLIP0ADK4
yiaW
b3587 JW3559 integral IM protein (SEC in IM), YiaWIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.107TMH011.1792-22No6-25i46-66oCytoplasmicMembrane1020
YICN_ECOLIP0ADL3
yicN
b3663 JW5637 integral IM protein (SEC in IM), YicNEcholocation says Membrane anchored, one or two TMH predicted, if signal peptide is also predicted these TMH(s) are not removed as it is probably not cleaved.Integral Inner MembraneB-N/AMembrane anchoredSRPSECyesyesN270.132CYT0-0.200913-10Yn6-17c21/22oUnknown223
GPMB_ECOLIP0A7A2
gpmB

ytjC

ytjCb4395 JW4358 integral IM protein (SEC in IM), Probable phosphoglycerate mutase GpmB Large potential TM 146-168aaIntegral Inner MembraneBBinoutout/inN/AMembrane anchoredSRPSECnoyesN170.117CYT0-0.200913-11No146-168iCytoplasmic956
DCTA_ECOLIP0A830
dctA
b3528 JW3496 integral IM protein (SEC-YidC in IM), Aerobic C4-dicarboxylate transport protein DctAIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSEC-YidCnoyesN190.136TMH05.74612-88Ni9-27o47-64i76-99o141-164i184-208o220-242i326-344o350-373iCytoplasmicMembrane10
TATE_ECOLIP0A843
tatE

ybeC

ybeCb0627 JW0622 integral IM protein (SEC in IM), Sec-independent translocase TatE Integral Inner Membrane TatA paralog TatE can substitute for TatA and support translocation of Tat substrates including AmiA, AmiC, and TorA.PMID: 22190680Integral Inner MembraneBBoutout/inIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN430.118CYT0-0.200913-10Yn9-20c29/30oCytoplasmicMembrane9127
ZUPT_ECOLIP0A8H3
zupT

ygiE

ygiEb3040 JW3008 integral IM protein (SEC in IM), Zinc transporter ZupT Integral Inner MembraneBBpolyout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN590.198TMH010.378-67No6-25i32-50o62-81i125-150o170-192i199-215o235-256iCytoplasmicMembrane1027
YIHY_ECOLIP0A8K8
yihY
b3886 JW3857 b2268integral IM protein (SEC in IM), UPF0761 YihYIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane CytoplasmicSRPSECyesyesN600.127CYT0-0.200913-67No39-61i73-91o103-120i141-160o180-200i212-234o240-266iCytoplasmicMembrane10
YIDG_ECOLIP0ADL6
yidG
b3675 JW3651 integral IM protein (SEC in IM), YidGIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN470.125TMH05.45771-33Ni21-39o45-65i91-116oCytoplasmicMembrane1021
YIDH_ECOLIP0ADM0
yidH
b3676 JW3652 integral IM protein (SEC in IM), YidHIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.135TMH01.23486-33Ni21-39o54-72i93-114oCytoplasmicMembrane1020
YGAM_ECOLIP0ADQ7
ygaM
b2672 JW2647 integral IM protein (SEC in IM), YgaMIntegral Inner Membrane YgaM is paralogous to YqjD and binds to ribsomes in a similar manner to YqjD. PMID: 22661687PMID: 22661687Integral Inner MembraneBBinin/outIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECnoyesN400.127CYT0-0.200913-11Ni87-106oUnknown250
YQAE_ECOLIP0AE42
yqaE
b2666 JW2641 integral IM protein (SEC in IM), UPF0057 YqaEIntegral Inner MembraneBBinoutout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN270.14TMH06.73627-21No23-48iCytoplasmicMembrane10
FRDC_ECOLIP0A8Q0
frdC
b4152 JW4113 integral IM protein (SEC in IM), Fumarate reductase subunit C FrdCIntegral Inner Membrane Alpha-helcal transmembrane protein (experimental). Transmembrane helices: 3. N-terminal region is in cytoplasm. Helix A and B connected by very short turns to an interfacial helix (N51-L63)PMID: 24057063.PMID: 11266632 PMID: 10373108 PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN590.224TMH01.78374-33Ni26-48o68-88i109-130oCytoplasmicMembrane109
FRDD_ECOLIP0A8Q3
frdD
b4151 JW4112 integral IM protein (SEC in IM), Fumarate reductase subunit D FrdDIntegral Inner Membrane Alpha-helcal transmembrane protein (experimental). Transmembrane helices: 3 PMID: 10373108.PMID: 11266632 PMID: 10373108 PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN520.162TMH015.5267-33Ni12-45o57-78i99-118oCytoplasmicMembrane107
YCJF_ECOLIP0A8R7
ycjF
b1322 JW1315 integral IM protein (SEC in IM), UPF0283 YcjFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.1CYT0-0.200913-34Ni70-87o99-120i214-236o256-275iCytoplasmicMembrane1010
PGPB_ECOLIP0A924
pgpB
b1278 JW1270 integral IM protein (SEC in IM), Phosphatidylglycerophosphatase B PgpBIntegral Inner Membrane PgpB protein has phosphatidyl glycerophosphate phosphatase activity higher in the cytoplasmic membrane, while it has phosphatidic acid and lysophosphatidic acid phosphatase activities higher in the outer membrane.PMID: 2846511 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN240.144TMH017.4928-66Ni12-29o49-68i75-96o157-178i185-206o212-230iCytoplasmicMembrane10
YJIG_ECOLIP0AEH8
yjiG
b4329 JW4292 integral IM protein (SEC in IM), YjiGIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN360.157TMH02.83449-34Ni21-39o59-77i89-110o130-152iCytoplasmicMembrane102
YIIR_ECOLIP0AF34
yiiR
b3921 JW3892 integral IM protein (SEC in IM), YiiRIntegral Inner MembraneBBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN380.144TMH05.06913-44Ni20-38o44-63i75-93o99-121iCytoplasmicMembrane1049
YIJD_ECOLIP0AF40
yijD
b3964 JW3936 integral IM protein (SEC in IM), YijDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN270.345TMH08.09717-43Yn10-21c26/27o36-51i63-83o89-108iCytoplasmicMembrane1021
YJCH_ECOLIP0AF54
yjcH
b4068 JW4029 integral IM protein (SEC in IM), YjcHIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN480.119TMH04.65174-22Ni25-51o63-84iCytoplasmicMembrane1054
PLAP_ECOLIP0AA47
plaP

yeeF

yeeFb2014 JW5330 integral IM protein (SEC in IM), Low-affinity putrescine importer PlaPIntegral Inner Membrane Old gene name YeeF.PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.148TMH08.96423-1212Ni20-42o54-73i94-116o128-146i158-179o199-217i237-260o287-315i336-355o361-383i395-413o419-437iCytoplasmicMembrane10
YFDV_ECOLIP0AA49
yfdV
b2372 JW2369 integral IM protein (SEC in IM), transporter YfdVIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane Protein (Experimental)SRPSECnoyesN570.126CYT0-0.200913-1010No6-23i35-55o67-90i97-117o129-150i175-196o202-222i234-253o259-278i290-309oCytoplasmicMembrane10
QMCA_ECOLIP0AA53
qmcA

ybbK

ybbKb0489 JW0478 integral IM protein (SEC in IM), QmcAIntegral Inner Membrane PMID: 16573693Integral Inner MembraneBBoutin/outIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN180.11TMH01.35378-10Yn2-13c18/19oUnknown213
YGHB_ECOLIP0AA60
yghB
b3009 JW2976 integral IM protein (SEC in IM) of DedA family, YghBIntegral Inner Membrane Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF.PMID: 15919996 PMID: 23086209Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.338TMH00.0786812-46No20-38i45-62o68-88i123-143o155-176i188-212oCytoplasmicMembrane108
YQJA_ECOLIP0AA63
yqjA
b3095 JW3066 integral IM protein (SEC in IM) of DedA family, YqjAIntegral Inner Membrane Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF.PMID: 15919996 PMID: 23086209Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein SRPSECyesyesN210.127TMH04.47784-66No20-38i45-62o68-88i123-143o155-176i188-212oCytoplasmicMembrane103
YJET_ECOLIP0AF73
yjeT
b4176 JW4134 integral IM protein (SEC in IM), YjeTIntegral Inner MembraneBBinoutin/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN270.108TMH04.78812-21Yn3-13c17/18o41-60iCytoplasmicMembrane919
YJFL_ECOLIP0AF80
yjfL
b4184 JW4142 integral IM protein (SEC in IM), UPF0719 YjfLIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN220.123TMH08.65955-44No6-28i49-69o75-97i109-128oCytoplasmicMembrane1019
PSPC_ECOLIP0AFN2
pspC
b1306 JW1299 integral IM protein (SEC in IM), Phage shock C PspCIntegral Inner Membrane Defects in yidC and sec secretion induce psp operon. PMID: 14594846PMID: 14594846Integral Inner MembraneBBinoutout/inIM (predicted)Cell inner membrane Membrane anchoredSRPSECProphage TransposaseyesnoN250.142CYT0-0.200913-11No39-64iCytoplasmicMembrane929
YMIA_ECOLIP0CB62
ymiA
b4522 JW1267.1 integral IM protein (SEC in IM), YmiAIntegral Inner Membrane Small membrane protein detected experimentallyPMID: 19121005Integral Inner MembraneBBinoutin/outN/AMembrane -SECnoyesN350.102TMH01.19842-11Ni20-41oCytoplasmicMembrane9
RHTA_ECOLIP0AA67
rhtA

ybiF

ybiFb0813 JW0798 integral IM protein (SEC in IM), Threonine/homoserine exporter RhtA Integral Inner Membrane PMID: 12648727 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN320.17TMH06.46418-109Yn10-18c22/23o38-59i71-89o95-115i122-139o145-165i177-196o202-225i237-258o264-283iCytoplasmicMembrane10
YEDA_ECOLIP0AA70
yedA
b1959 JW1942 integral IM protein (SEC in IM), transporter YedAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN410.125TMH011.0617-109Yn6-16c21/22o37-56i68-86o98-117i124-143o149-169i176-199o211-233i245-262o268-290iCytoplasmicMembrane10
YHBE_ECOLIP0AA73
yhbE
b3184 JW3151 integral IM protein (SEC in IM), transporter YhbEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.149TMH00.144382-1010Ni7-26o38-56i71-91o103-120i132-151o157-177i189-205o217-236i248-269o281-299iCytoplasmicMembrane10
DGOT_ECOLIP0AA76
dgoT

yidT

yidTb3691 JW5859 integral IM protein (SEC-YidC in IM), D-galactonate transporter DgoTIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN430.138TMH04.18214-1112Ni15-35o55-75i82-98o104-122i142-163o169-188i242-263o283-304i316-332o338-362i369-392o404-424iCytoplasmicMembrane10
EXUT_ECOLIP0AA78
exuT
b3093 JW3064 integral IM protein (SEC in IM), Hexuronate transporter ExuTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN180.107TMH00.456812-1112Ni47-66o86-109i116-136o142-162i174-199o205-224i277-299o305-325i345-362o368-389i401-424o430-452iCytoplasmicMembrane10
PHNE1_ECOLIP0DP69
phnE1
b4104 JW4065integral IM protein (SEC in IM), Putative cryptic phosphonate transport system permease PhnE1 Integral Inner Membrane Integral Inner MembraneBN/ACell inner membrane -SECpseudogene (Uniprot)N0.119CYT00.401335-33Yi30-50o92-116i137-157oUnknown
LDRA_ECOLIP0DPD0
ldrA
b4419 JW5957integral IM protein (SEC in IM), Small toxic polypeptide LdrAIntegral Inner Membrane Potentially toxic protein.PMID: 19121005Integral Inner MembraneBBinoutout/inIM (predicted)Cell inner membrane CytoplasmicSRPSECyesyesN210.125CYT0-0.200913-11No6-31iCytoplasmicMembrane9
LDRC_ECOLIP0DPD1
ldrC
b4423 JW5959integral IM protein (SEC in IM), Small toxic polypeptide LdrCIntegral Inner Membrane Integral Inner MembraneBN/ACell inner membrane -SECN0.125CYT0-0.200913-11Yo6-31iUnknown
YIAB_ECOLIP11286
yiaB
b3563 JW5654 integral IM protein (SEC in IM), YiaBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN500.132TMH07.23112-44Ni7-26o32-50i62-87o93-110iCytoplasmicMembrane1038
GARP_ECOLIP0AA80
garP

yhaU

yhaUb3127 JW3096 integral IM protein (SEC in IM), Probable galactarate transporter GarPIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.195TMH03.99251-1112Ni12-32o52-73i85-103o109-130i151-173o179-199i251-270o290-314i326-345o351-372i379-406o412-434iCytoplasmicMembrane10
CODB_ECOLIP0AA82
codB
b0336 JW0327 integral IM protein (SEC-YidC in IM), Cytosine permease CodBIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCnoyesN380.154TMH012.7134-1212Ni20-40o52-74i95-118o130-147i152-173o193-212i224-253o259-278i299-318o324-345i357-379o385-402iCytoplasmicMembrane10
DSBE_ECOLIP0AA86
dsbE

ccmG yejQ

ccmG yejQb2195 JW2183 integral IM protein (SEC in IM), Thiol:disulfide interchange DsbE Integral Inner Membrane PMID: 9537397 PMID: 16364305 Integral Inner MembraneBBoutin/outN/ACell inner membrane; Single-pass membrane protein; Periplasmic sidePeriplasmic with N-terminal membrane anchor (Experimental)SRPSECyesyesN290.264SpI278.59712-10Yn6-21c30/31oCytoplasmicMembrane1069
YPDA_ECOLIP0AA93
ypdA
b2380 JW5388 integral IM protein (SEC in IM), Sensor histidine kinase YpdAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN160.103TMH01.16348-66No6-25i45-64o76-99i106-128o140-161i173-191oCytoplasmicMembrane10
FLIO_ECOLIP22586
fliO

flaP flbD

flaP flbDb1947 JW5316 Flagellar integral IM protein (SEC in IM), FliOIntegral Inner MembraneBBinoutout/inIM (predicted)Cell membrane Membrane anchoredflagellumSRPSECnoyesN270.161TMH00.0866025-11No18-39iCytoplasmicMembrane914
APPX_ECOLIP24244
appX

yccB

yccBb4592 JW0961.1 b0979.1integral IM protein (SEC in IM), Putative cytochrome bd-II ubiquinol oxidase subunit AppX Integral Inner Membrane Experimentally verified orientation: N(out)-C(in).PMID: 19121005 PMID: 21778229Integral Inner MembraneBBinoutout/inN/ACell inner membrane Integral Membrane ProteinSRPSECnoyesN210.107TMH02.07613-11No6-24iCytoplasmicMembrane9
YIGF_ECOLIP27842
yigF
b3817 JW3790 integral IM protein (SEC in IM), YigFIntegral Inner MembraneBBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECnoyesN400.108CYT0-0.200913-22Ni52-72o78-107iCytoplasmicMembrane925
YIGG_ECOLIP27843
yigG
b3818 JW5590 integral IM protein (SEC in IM), YigGIntegral Inner Membrane PMID: 11867724 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN420.121TMH05.14332-44Ni18-35o41-57i69-91o103-121iCytoplasmicMembrane10
YAGU_ECOLIP0AAA1
yagU
b0287 JW0281 integral IM protein (SEC in IM), YagUIntegral Inner Membrane PMID: 16079137 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECnoyesN300.316SpI293.31288-34Ni14-35o98-120i132-150o162-182iCytoplasmicMembrane1044
WZXE_ECOLIP0AAA7
wzxE

wzx yifJ

wzx yifJb3792 JW3766 integral IM protein (SEC in IM), Lipid III flippase WzxEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN410.139TMH05.34268-1211Yn6-16c21/22o45-67i79-105o117-138i145-164o176-195i216-237o257-278i299-322o334-355i362-382o394-412iCytoplasmicMembrane10
YBHL_ECOLIP0AAC4
ybhL
b0786 JW0769 integral IM protein (SEC in IM), YbhLIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.151TMH05.60898-77Ni20-42o57-77i89-107o113-131i143-161o167-186i207-230oCytoplasmicMembrane10
YCCA_ECOLIP0AAC6
yccA
b0970 JW0953 integral IM protein (SEC in IM), Modulator of FtsH protease YccA Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane protein Integral Membrane ProteinSRPSECyesyesN420.268TMH07.78202-77Ni20-41o47-67i74-94o106-126i133-154o160-184i196-216oCytoplasmicMembrane10
MTR_ECOLIP0AAD2
mtr
b3161 JW3130 integral IM protein (SEC in IM), Tryptophan-specific transport MtrIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN470.192TMH019.2156-1111Ni12-34o40-65i86-107o127-145i152-170o190-207i228-246o284-309i321-340o346-367i388-410oCytoplasmicMembrane10
YHHH_ECOLIP28911
yhhH
b3483 JW3449 integral IM protein (SEC in IM), YhhHIntegral Inner MembraneBBoutin/outIM (predicted)Membrane anchoredSRPSECnoyesN320.366CYT0-0.200913-11Ni12-30oUnknown252
YIDI_ECOLIP31446
yidI
b3677 JW3653 integral IM protein (SEC in IM), YidIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN360.149TMH00.964289-33Ni12-30o78-98i110-143oCytoplasmicMembrane1027
CBRB_ECOLIP31468
cbrB

yieI

yieIb3716 JW3694 integral IM protein (SEC in IM), CbrBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN340.114TMH014.4652-44Ni12-32o38-69i81-100o120-138iCytoplasmicMembrane1025
TYRP_ECOLIP0AAD4
tyrP
b1907 JW1895 integral IM protein (SEC in IM), Tyrosine-specific transport TyrPIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN290.164TMH011.6392-1110Yn6-17c29/30o39-58i78-100o120-141i148-169o181-204i216-235o273-298i310-330o336-355i376-399oCytoplasmicMembrane10
SDAC_ECOLIP0AAD6
sdaC

dcrA

dcrAb2796 JW2767 integral IM protein (SEC in IM), Serine transporter SdaCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN360.132TMH010.9503-1111Ni24-43o49-67i100-120o140-157i164-187o207-229i250-273o300-324i345-364o370-394i406-428oCytoplasmicMembrane10
TDCC_ECOLIP0AAD8
tdcC
b3116 JW3087 integral IM protein (SEC in IM), Threonine/serine transporter TdcC Integral Inner Membrane Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 15919996 PMID: 25403562Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECYfgMyesyesN350.131TMH09.58087-1111Ni23-42o48-66i97-116o136-155i167-186o206-234i255-278o317-337i358-379o391-409i421-440oCytoplasmicMembrane10
CYCA_ECOLIP0AAE0
cycA

dagA ytfD

dagA ytfDb4208 JW4166 integral IM protein (SEC-YidC in IM), D-serine/D-alanine/glycine transporter CycAIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN530.108TMH03.35425-1212Ni28-45o51-71i108-130o136-154i166-187o207-231i252-274o286-311i347-365o371-397i417-435o441-460iCytoplasmicMembrane10
YDCD_ECOLIP31991
ydcD
b1457 JW1452 integral IM protein (SEC in IM), YdcDIntegral Inner MembraneBBoutin/outIM (predicted)Membrane anchoredSRPSECnoyesN320.142CYT0-0.200913-11Ni7-25oUnknown29
YIBI_ECOLIP32108
yibI
b3598 JW3572 integral IM protein (SEC in IM), YibIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN270.12TMH012.0249-22No6-25i46-66oCytoplasmicMembrane1033
PSPG_ECOLIP32696
pspG

yjbO

yjbOb4050 JW5716 integral IM protein (SEC in IM), Phage shock G PspGIntegral Inner Membrane PMID: 19555453Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECProphage TransposasenonoN320.133TMH016.1628-22Ni7-37o43-64iCytoplasmicMembrane9
YJCB_ECOLIP32700
yjcB
b4060 JW5718 integral IM protein (SEC in IM), YjcBIntegral Inner Membrane PMID: 19555453Integral Inner MembraneBBpolyout/outIM (predicted)Integral Membrane ProteinSRPSECyesyesN650.12TMH09.92398-22No12-29i36-56oCytoplasmicMembrane945
PROY_ECOLIP0AAE2
proY

yajM

yajMb0402 JW5055 integral IM protein (SEC in IM), Proline-specific permease ProY Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN480.136TMH06.32309-1212Ni16-34o40-59i95-118o124-142i154-176o196-218i239-258o278-298i330-350o356-377i398-421o427-445iCytoplasmicMembrane10
ARCD_ECOLIP0AAE5
ydgI
b1605 JW1597 nucleoid & integral IM protein (SEC in IM), Putative arginine/ornithine antiporter YdgIIntegral Inner Membrane, NucleoidPMID: 23138451 PMID: 15919996Integral Inner Membrane, NucleoidB, Nout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN220.206TMH08.33129-1312Yn5-16c25/26o41-61i82-107o127-145i157-178o204-222i234-257o283-311i332-352o358-378i385-402o408-426i441-459oCytoplasmicMembrane10
CADB_ECOLIP0AAE8
cadB
b4132 JW4093 integral IM protein (SEC-YidC in IM), Probable cadaverine/lysine antiporter CadBIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN180.152TMH09.00829-1212Ni7-28o40-58i94-115o121-139i146-169o189-208i220-238o258-283i323-344o350-371i383-401o407-424iCytoplasmicMembrane10
POTE_ECOLIP0AAF1
potE
b0692 JW0679 integral IM protein (SEC in IM), Putrescine transporter PotE PotEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN500.144TMH05.94665-1212Ni12-30o42-60i90-110o122-140i152-172o184-204i225-249o276-300i321-345o351-374i386-404o410-428iCytoplasmicMembrane10
NRFF_ECOLIP32711
nrfF

yjcM

yjcMb4075 JW4036 integral IM protein (SEC in IM), Formate-dependent nitrite reductase complex subunit NrfF Integral Inner MembraneBBoutout/inIM (predicted)Periplasm Membrane anchoredSRPSECnoyesY190.845SpI1816.61-11Yn4-14c18/19o103-121iCytoplasmicMembrane1020
MOKC_ECOLIP33236
mokC

gefL

gefLb0018 JW5879 integral IM protein (SEC in IM), Regulatory MokCIntegral Inner MembraneBBoutin/outN/ACell inner membrane PeriplasmicSRPSECnoyesN410.287SpI401.37208-11Ni25-44oPeriplasmic9
YBBD_ECOLIP33669
ybbD
b0501 JW0489 integral IM protein (SEC in IM), Putative YbbDIntegral Inner MembraneBBinout/inIM (predicted)Membrane Membrane anchoredSRPSECpseudogene (Uniprot) nonoN350.114TMH09.05171-11No12-32iCytoplasmicMembrane946
PPDD_ECOLIP36647
ppdD
b0108 JW0104 integral IM protein (SEC in IM), Prepilin peptidase-dependent D PpdDIntegral Inner MembraneBBoutin/outIM (predicted)FimbriumMembrane anchoredSRPSECnoyesN530.143TMH04.07217-11Ni12-30oExtracellular99
MDLB_ECOLIP0AAG5
mdlB

mdl

mdlb0449 JW5061 integral IM protein (SEC in IM), Multidrug resistance-like ATP-binding MdlB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN380.136SpI374.21577-44Yn25-32c37/38o61-81i138-161o167-185i250-273oCytoplasmicMembrane106
FTSH_ECOLIP0AAI3
ftsH

hflB mrsC std tolZ

hflB mrsC std tolZb3178 JW3145 integral IM protein (SEC in IM), ATP-dependent zinc metalloprotease FtsHIntegral Inner Membrane Trigger factor-sensitive aggregation. PMID: 8444797 PMID: 1925026 PMID: 8106505 PMID: 8106505 PMID: 7781608PMID: 7500942 PMID: 19737520 PMID: 8444797 PMID: 8947034 PMID: 15919657 PMID: 15919996 PMID: 1925026 PMID: 8106505 PMID: 7781608Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRP,TFSECnoyesN240.152SpI212.2847-21Yn5-16c21/22o98-119iCytoplasmicMembrane1041
FDNH_ECOLIP0AAJ3
fdnH
b1475 JW1471 integral IM protein (SEC in IM), Formate dehydrogenase, nitrate-inducible, iron-sulfur subunit FdnHIntegral Inner Membrane Part of the formate dehydrogenase N (FDH-N) of Escherichia coli which is a membrane-bound enzyme comprising FdnG, FdnH, and FdnI subunits. PMID: 11884747 PMID: 16858726PMID: 15342602 PMID: 16858726 PMID: 11266632 PMID: 11884747Integral Inner MembraneBBinin/outIM (predicted)Cell inner membrane Membrane anchored (Experimental)SRPSECyesyesN240.116CYT0-0.200913-11Ni260-279oCytoplasmicMembrane1080
HOKA_ECOLIP37305
hokA

yiaZ

yiaZb4455 JW3526 integral IM protein (SEC in IM), HokAIntegral Inner Membrane Potentially toxic protein.PMID: 19121005Integral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane Membrane anchoredSRPSECnoyesN250.11CYT0-0.200913-11Ni7-24oPeriplasmic9110
YHHL_ECOLIP37614
yhhL
b3466 JW5683 integral IM protein (SEC in IM), YhhLIntegral Inner MembraneBBinoutout/outIM (predicted)Integral Membrane ProteinSRPSECnoyesN250.114TMH01.98334-21Yn8-19c24/25o34-51iCytoplasmicMembrane947
YHHM_ECOLIP37615
yhhM
b3467 JW3432 integral IM protein (SEC in IM), YhhMSingle transmembrane helice predicted which would be removed upon signal peptide cleavage IM-cter inside.Integral Inner MembraneBBinout/inN/AMembrane anchoredSRPSECyesyesN320.135CYT0-0.200913-11No6-24iUnknown275
SIEB_ECOLIP38392
sieB
b1353 JW5209 integral IM protein (SEC in IM), Superinfection exclusion B SieBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)nonoN420.105TMH03.43476-22Ni20-38o50-70iCytoplasmicMembrane1013
CYBH_ECOLIP0AAM1
hyaC
b0974 JW0956 integral IM protein (SEC in IM), Probable Ni/Fe-hydrogenase 1 B-type cytochrome subunit HyaCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.112TMH010.0819-46No20-40i61-80o100-116i128-151o157-174i186-203oCytoplasmicMembrane10
DGCC_ECOLIP0AAP1
dgcC

adrA yaiC

adrA yaiCb0385 JW0376 integral IM protein (SEC in IM), Probable diguanylate cyclase DgcCIntegral Inner Membrane PMID: 10760159 PMID: 12673057 PMID: 16585767Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane Protein(experimental)SRPSECyesyesN200.116CYT0-0.200913-55Ni43-61o67-85i106-130o142-167i174-193oCytoplasmicMembrane1022
YBBJ_ECOLIP0AAS3
ybbJ
b0488 JW5065 integral IM protein (SEC in IM), YbbJIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN230.17TMH018.8226-33No6-23i30-49o55-72iCytoplasmicMembrane1012
YBDG_ECOLIP0AAT4
ybdG

mscM

mscMb0577 JW0566 integral IM protein (SEC in IM), Miniconductance mechanosensitive channel YbdG Integral Inner Membrane Mechanosensitive channel of miniconductance activity (MscM).PMID: 20616037 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN390.102CYT0-0.200913-55No23-48i68-87o107-127i139-160o166-183iCytoplasmicMembrane1011
ACRZ_ECOLIP0AAW9
acrZ

ybhT

ybhTb0762 JW5102 integral IM protein (SEC-YidC in IM), Multidrug efflux pump accessory AcrZ Integral Inner Membrane Experimentally verified orientation: N(out)-C(in). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased.PMID: 19121005 PMID: 21778229Integral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane Membrane anchoredSRPSEC-YidCnoyesN210.157TMH01.49031-11Ni7-29oCytoplasmicMembrane928
YJEO_ECOLIP39284
yjeO
b4158 JW4119 integral IM protein (SEC in IM), YjeOIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.227TMH07.24951-32Yn6-17c25/26o55-72i79-98oCytoplasmicMembrane1056
YTFB_ECOLIP39310
ytfB
b4206 JW5745 integral IM protein (SEC in IM), Cell division YtfBIntegral Inner MembraneBBinoutin/outIM (predicted)Cell inner membrane CytoplasmicSRPSECnoyesN570.108CYT0-0.200913-01Ni30-48oExtracellular957
YJGX_ECOLIP39349
yjgX
b4575 b4275/b4276/b4560integral IM protein (SEC in IM), Putative phosphoethanolamine transferase YjgX Integral Inner MembraneBBinout/inIM (predicted)Cell inner membrane CytoplasmicSRPSECpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoN310.126TMH04.71526-11No6-25iCytoplasmicMembrane1049
ELYC_ECOLIP0AB01
elyC

ycbC

ycbCb0920 JW0903 integral IM protein (SEC in IM), Envelope biogenesis factor ElyCIntegral Inner Membrane Shown to play a critical role in the metabolism of the essential lipid carrier used for the biogenesis of cell wall and other bacterial surface polysaccharides.PMCID: PMC3879167Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN600.155TMH09.49418-22No12-32i41-59oCytoplasmicMembrane924
YCCF_ECOLIP0AB12
yccF
b0961 JW0944 integral IM protein (SEC in IM), YccFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN240.116TMH02.25765-33Ni7-33o69-90i102-123oCytoplasmicMembrane10
LAPB_ECOLIP0AB58
LapB

yciM

yciMb1280 JW1272 integral IM protein (SEC in IM), polysaccharide assembly B LapBIntegral Inner Membrane Potential TAT secreted protein. Required to maintain cell envelope integrity. Heat shock protein that is involved in the assembly of LPS PMID: 24722986 Heat shock protein that is involved in the assembly of LPS PMID: 24722986 Heat shock protein involved in the assembly of LPS. In pull-down experiments, LapA and LapB co-purified with LPS, Lpt proteins, FtsH (protease), DnaK, and DnaJ (chaperones). A specific interaction was also observed between WaaC and LapB. LapB potentially coordinates assembly of proteins involved in LPS synthesis at the plasma membrane and regulates turnover of LpxC. PMID: 25403562PMID: 24187084 PMID: 25403562Integral Inner MembraneB-Soluble IM FractionCell inner membrane PeriplasmicSECyesyesN250.264CYT0-0.200913-00Yn4-11c16/17oCytoplasmic89
PNTB_ECOLIP0AB67
pntB
b1602 JW1594 integral IM protein (SEC in IM), NAD(P) transhydrogenase subunit beta PntBIntegral Inner Membrane PMID: 14660605 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.125TMH09.6368-99No6-24i36-51o57-74i86-105o125-143i163-180o186-207i214-234o240-260iCytoplasmicMembrane10
YJHE_ECOLIP39355
yjhE
b4282 integral IM protein (SEC in IM), Putative YjhEIntegral Inner MembraneB-IM (predicted)Cell membrane Integral Membrane ProteinSRPSECpseudogene (Uniprot) nonoN380.334CYT0-0.200913-22Ni22-49o55-76iCytoplasmicMembrane1015
YJIH_ECOLIP39379
yjiH
b4330 JW5783 integral IM protein (SEC in IM), YjiHIntegral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN380.143TMH05.26808-44Ni21-39o86-104i116-135o176-201iCytoplasmicMembrane916
YGJQ_ECOLIP42598
ygjQ
b3086 JW3057 integral IM protein (SEC in IM), YgjQIntegral Inner MembraneBBoutin/outN/AMembrane PeriplasmicSRPSECnoyesN370.199SpI366.02153-10Yn21-31c36/37oCytoplasmicMembrane9
YGJV_ECOLIP42603
ygjV
b3090 JW3061 integral IM protein (SEC in IM), YgjVIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN560.156TMH04.26984-55No6-24i36-59o71-89i101-124o136-157iCytoplasmicMembrane10
ARSB_ECOLIP0AB93
arsB

arsF

arsFb3502 JW3469 integral IM protein (SEC in IM), Arsenical pump ArsBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN440.23TMH08.42262-1110Yn2-17c35/36o51-70i91-109o115-132i139-163o175-198i222-240o246-263i275-296o316-334i401-423oCytoplasmicMembrane10
ATP6_ECOLIP0AB98
atpB

papD uncB

papD uncBb3738 JW3716 integral IM protein (SEC-YidC in IM), ATP synthase subunit a AtpBIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC. PMID: 10806384PMID: 22108384 PMID: 15263011 PMID: 15919996 PMID: 10806384Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPSEC-YidCyesyesN670.123CYT0-0.200913-55No36-60i100-118o147-166i211-233o239-264iCytoplasmicMembrane107
ATPF_ECOLIP0ABA0
atpF

papF uncF

papF uncFb3736 JW3714 integral IM protein (SEC in IM), ATP synthase subunit b AtpFIntegral Inner Membrane PMID: 15263011 PMID: 21541338 PMID: 6278247Integral Inner MembraneBBinout/inSoluble IM FractionCell inner membrane Membrane anchored (Experimental)SRPSECnoyesN320.35CYT0-0.200913-11No6-26iCytoplasmicMembrane1019
ATMA_ECOLIP0ABB8
mgtA

corB mgt

corB mgtb4242 JW4201 integral IM protein (SEC in IM), Magnesium-transporting ATPase, P-type 1 MgtAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN470.122CYT0-0.200913-78Ni89-112o118-137i291-309o315-342i768-791o803-821i833-857o869-891iCytoplasmicMembrane1050
MZRA_ECOLIP42615
mzrA

ecfM yqjB

ecfM yqjBb3096 JW3067 integral IM protein (SEC in IM), Modulator of the activity of the EnvZ/OmpR two-component regulatory system MzrAIntegral Inner Membrane PMID: 19432797 PMID: 20889743Integral Inner MembraneBBoutin/outN/ACell inner membrane Membrane anchoredSRPSECyesyesN300.154SpI294.521-10Yn11-22c27/28oUnknown214
YQJF_ECOLIP42619
yqjF
b3101 JW5850 integral IM protein (SEC in IM), YqjFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.118TMH08.80873-44Ni7-26o46-66i73-91o103-122iCytoplasmicMembrane10
ATPZ_ECOLIP0ABC0
atpI

uncI

uncIb3739 JW5611 integral IM protein (SEC-YidC in IM), ATP synthase I AtpIIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN640.113TMH04.01303-43Yn14-25c30/31o40-59i71-94o100-122iCytoplasmicMembrane1034
HFLC_ECOLIP0ABC3
hflC

hflA

hflAb4175 JW4133 integral IM protein (SEC in IM), Modulator of FtsH protease HflC Integral Inner Membrane N-terminally located transmembrane segment. PMID: 9792691 Translocation of the C-terminal domains of HflKC was retarded markedly when sodium azide was added to inhibit SecA ATPase and blocked almost completely in secY- or secD-defective mutant cells. PMID: 9792691PMID: 8947034 PMID: 16834335 PMID: 9792691Integral Inner MembraneBBinout/inSoluble IM FractionCell inner membrane Membrane anchored (Experimental)SRPSECProphage Transposase (by homology to BL21)yesyesN250.135CYT0-0.200913-11No6-23iCytoplasmic846
HFLK_ECOLIP0ABC7
hflK

hflA

hflAb4174 JW4132 integral IM protein (SEC in IM), Modulator of FtsH protease HflK Integral Inner Membrane Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 N-terminally located transmembrane segment. PMID: 9792691 Translocation of the C-terminal domains of HflKC was retarded markedly when sodium azide was added to inhibit SecA ATPase and blocked almost completely in secY- or secD-defective mutant cells. PMID: 9792691PMID: 8947034 PMID: 21541338 PMID: 9792691Integral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane Membrane anchoredSRPSECProphage TransposaseyesnoN30.101CYT0-0.200913-11Ni80-100oUnknown520
BETT_ECOLIP0ABC9
betT
b0314 JW0306 integral IM protein (SEC in IM), High-affinity choline transport protein BetTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN370.108TMH011.6116-1212Ni16-35o55-79i91-115o143-166i194-215o235-253i265-290o319-338i350-368o403-422i448-467o479-497iCytoplasmicMembrane10
YGAH_ECOLIP43667
ygaH
b2683 JW2658 integral IM protein (SEC in IM), YgaHIntegral Inner MembraneBBpolyout/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN180.142CYT0-0.200913-33Yn5-15c20/21o36-57i69-85o91-109iCytoplasmicMembrane10
YHDT_ECOLIP45566
yhdT
b3257 JW3225 integral IM protein (SEC in IM), YhdTIntegral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN300.15TMH015.9222-22Ni12-33o45-65iCytoplasmicMembrane943
YBCI_ECOLIP45570
ybcI
b0527 JW0516 integral IM protein (SEC in IM), YbcIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN410.121TMH04.35035-44Ni27-47o59-78i85-103o149-170iCytoplasmicMembrane104
YEAV_ECOLIP0ABD1
yeaV
b1801 JW5293 integral IM protein (SEC in IM), transporter YeaVIntegral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN190.119TMH02.33182-1011Yn2-13c18/19o34-59i80-104o136-158i170-191o203-221i228-246o258-277i289-308o348-371i392-412o418-438iCytoplasmicMembrane10
C561_ECOLIP0ABE5
cybB
b1418 JW5224 integral IM protein (SEC-YidC in IM), Cytochrome b561 CybBIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCnoyesN230.142TMH07.83021-44Ni12-33o39-62i82-106o143-162iCytoplasmicMembrane1031
PGSA_ECOLIP0ABF8
pgsA
b1912 JW1897 integral IM protein (SEC in IM), CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase PgsAIntegral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 12558186 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN350.17TMH012.5336-46Ni7-27o33-52i64-83o89-108i120-142o148-169iCytoplasmicMembrane107
CDSA_ECOLIP0ABG1
cdsA

cds

cdsb0175 JW5810 integral IM protein (SEC in IM), Phosphatidate cytidylyltransferase CdsAIntegral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. PMID: 15919996PMID: 9008159 PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRP (exp)SECyesyesN300.287TMH018.3357-88Yn6-13c18/19o28-44i56-73o93-113i120-141o153-171i192-210o216-234i264-282oCytoplasmicMembrane10
FTSW_ECOLIP0ABG4
ftsW
b0089 JW0087 integral IM protein (SEC in IM), Probable PG glycosyltransferase FtsW Integral Inner Membrane Interacts directly with FtsN. The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex.PMID: 20847002 PMID: 20497333 PMID: 9603865 PMID: 12423747 PMID: 11807049 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN670.137TMH010.7628-109Yn15-26c32/33o48-66i87-104o110-129i175-192o198-215i222-239o307-328i340-364o376-395iCytoplasmicMembrane10
HOFO_ECOLIP45751
hofO

yrfB

yrfBb3393 JW3356 integral IM protein (SEC in IM), DNA utilization HofOIntegral Inner MembraneBBinout/inIM (predicted)Cell inner membrane Membrane anchoredSRPSECyesyesN400.213TMH06.9432-11No20-38iUnknown219
YBJC_ECOLIP46119
ybjC
b0850 JW0834 integral IM protein (SEC in IM), YbjCIntegral Inner MembraneBBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN260.131TMH06.40394-22Ni12-29o44-68iCytoplasmicMembrane945
RODA_ECOLIP0ABG7
mrdB

rodA

rodAb0634 JW0629 integral IM protein (SEC in IM), PG glycosyltransferase MrdB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN410.198TMH06.46483-99No20-38i50-68o74-95i136-154o160-176i183-202o263-289i310-332o338-359iCytoplasmicMembrane10
CORA_ECOLIP0ABI4
corA
b3816 JW3789 integral IM protein (SEC-YidC in IM), Magnesium transport CorA Integral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC. Single particle electron microscopy analysis and two-dimensional crystals of PPD (large soluble periplasmic domain) of CorA indicated that E. coli CorA PPD is a pyramid-like homotetramer with a central cavity.PMID: 22108384 PMID: 15919996 PMID: 16835234Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN270.101CYT0-0.200913-22Ni255-278o290-310iCytoplasmicMembrane1065
CYOB_ECOLIP0ABI8
cyoB
b0431 JW0421 integral IM protein (SEC-YidC in IM), Cytochrome bo(3) ubiquinol oxidase subunit 1 CyoBIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 11017202 PMID: 11266632 PMID: 22108384 PMID: 6365921 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN310.108TMH010.2812-1414No16-38i59-79o103-126i146-170o190-213i233-255o275-298i310-334o346-368i380-403o415-436i457-479o491-518i593-626oCytoplasmicMembrane10
CYOA_ECOLIP0ABJ1
cyoA
b0432 JW0422 integral IM protein (SEC in IM), Cytochrome bo(3) ubiquinol oxidase subunit 2 CyoAIntegral Inner MembraneProven signal peptidase II substrate PMID: 15174130. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 The SRP interacts with the first TM of CyoA (rather than with its signal sequence) to mediate targeting of CyoA to the Sec/YidC insertion site in the inner membrane. PMID: 16481320 Efficient insertion of in vitro synthesized pre-CyoA into proteoliposomes requires YidC, SecYEG, and SecA and occurs independently of the proton motive force. PMID: 16513637PMID: 15174130 PMID: 11266632 PMID: 11017202 PMID: 6365921 PMID: 16079137 PMID: 15919657 PMID: 15919996 PMID: 21541338 PMID: 16481320 PMID: 16513637Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN310.189TMH011.3494-32Yn10-22c27/28o43-67i88-108oCytoplasmicMembrane1019
YGBE_ECOLIP46141
ygbE
b2749 JW2719 integral IM protein (SEC in IM), YgbEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.233TMH010.6872-33No23-46i53-79o85-106iCytoplasmicMembrane10
CYOC_ECOLIP0ABJ3
cyoC
b0430 JW0420 integral IM protein (SEC in IM), Cytochrome bo(3) ubiquinol oxidase subunit 3 CyoCIntegral Inner Membrane PMID: 11017202 PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN140.175TMH03.44396-55Ni29-50o70-91i98-118o138-165i177-201oCytoplasmicMembrane10
CYOD_ECOLIP0ABJ6
cyoD
b0429 JW0419 integral IM protein (SEC in IM), Cytochrome bo(3) ubiquinol oxidase subunit 4 CyoDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN440.15TMH014.0581-33No18-37i44-68o80-100iCytoplasmicMembrane10
CYDA_ECOLIP0ABJ9
cydA

cyd-1

cyd-1b0733 JW0722 integral IM protein (SEC in IM), Cytochrome bd-I ubiquinol oxidase subunit 1 CydAIntegral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 15013751 PMID: 16079137 PMID: 15919657 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRP (exp)SECyesyesN370.106TMH09.54728-99No20-42i54-71o91-116i128-151o184-208i220-238o388-409i421-444o471-494iCytoplasmicMembrane10
CYDB_ECOLIP0ABK2
cydB

cyd-2

cyd-2b0734 JW0723 integral IM protein (SEC in IM), Cytochrome bd-I ubiquinol oxidase subunit 2 CydBIntegral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 15013751 PMID: 16079137 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRP (exp)SECyesyesN290.118TMH010.5085-88Ni9-28o77-99i119-141o161-181i202-226o264-283i290-315o335-360iCytoplasmicMembrane10
RSEC_ECOLIP46187
rseC
b2570 JW2554 integral IM protein (SEC in IM), RseCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN250.187CYT0-0.200913-22Ni79-98o104-121iCytoplasmicMembrane1027
AAEX_ECOLIP46478
aaeX

yhcR

yhcRb3242 JW5541 integral IM protein (SEC in IM), AaeXIntegral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN210.106TMH010.7464-22No6-31i43-62oCytoplasmicMembrane934
YQGD_ECOLIP46879
yqgD
b2941 JW2908 integral IM protein (SEC in IM), YqgDIntegral Inner MembraneBBinoutout/inIM (predicted)Integral Membrane ProteinSRPSECpseudogene (Ecogene), pseudogene (Uniprot)nonoN620.118TMH01.01241-21No27-50iCytoplasmicMembrane9
NAPC_ECOLIP0ABL5
napC

yejX

yejXb2202 JW2190 integral IM protein (SEC in IM), Cytochrome c-type NapCIntegral Inner Membrane Nitrate reductase, napFDAGHBC, is located in the periplasm. E. coli also expresses two membrane-bound proton-translocating nitrate reductases, encoded by the narGHJI and narZYWV operons. PMID: 11844760 Electrons are fed into the NapAB dimer from a membrane-anchored tetra-heme cytochrome c,encoded by the napC gene. PMID: 8830238 PMID: 12186631PMID: 11844760 PMID: 8830238 PMID: 12186631Integral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane; Single-pass membrane proteinPeriplasmic with N-terminal membrane anchor (Experimental)SRPSECyesyesN520.116TMH06.01984-11Ni21-44oCytoplasmicMembrane1014
CCMB_ECOLIP0ABL8
ccmB

yejV

yejVb2200 JW2188 integral IM protein (SEC-YidC in IM), Heme exporter B CcmBIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN200.11TMH09.26722-66Ni21-39o45-70i82-103o123-145i157-180o192-215iCytoplasmicMembrane104
CCMC_ECOLIP0ABM1
ccmC

yejT yejU

yejT yejUb2199 JW2187 integral IM protein (SEC-YidC in IM), Heme exporter C CcmCIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC. CcmC, CcmE, and heme interact directly with each other, establishing a periplasmic heme delivery pathway for cytochrome c maturation. PMID: 11384983PMID: 22108384 PMID: 15919996 PMID: 11384983Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCnoyesN290.15TMH014.9856-66Ni21-43o63-84i91-113o133-149i161-182o202-221iCytoplasmicMembrane10
CCMH_ECOLIP0ABM9
ccmH

yejP

yejPb2194 JW2182 integral IM protein (SEC in IM), Cytochrome c-type biogenesis CcmHIntegral Inner Membrane Might be is co-translationally translocated through Sec translocon. CcmH is a periplasm-resident oxidoreductase anchored to the inner membrane by two transmembrane segments. Both N- and C-terminal domains are located and function in the periplasmic compartment. PMID: 22789558 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024PMID: 15838024 PMID: 15919996 PMID: 22789558Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesY190.795SpI188.87226-32Yn3-13c18/19o102-120i147-166oCytoplasmicMembrane1041
YPJK_ECOLIP52134
ypjK
b2635 JW5888 integral IM protein (SEC in IM), YpjKIntegral Inner MembraneBBinoutout/inIM (predicted)Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)nonoN460.265TMH05.94794-31Yn3-14c22/23o46-68iCytoplasmicMembrane10
YJJZ_ECOLIP55914
yjjZ
b4567 JW5797 integral IM protein (SEC in IM), YjjZIntegral Inner MembraneBBpolyin/outIM (predicted)Integral Membrane ProteinSRPSECyesyesN260.223TMH09.90172-33Ni7-25o31-48i55-75oCytoplasmicMembrane919
BLR_ECOLIP56976
blr
b4409 JW5963 integral IM protein (SEC in IM), Divisome-associated BlrIntegral Inner Membrane Small membrane protein detected experimentally.PMID: 19121005 PMID: 10931331 PMID: 22885295Integral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN270.106CYT0-0.200913-11Ni7-26oCytoplasmicMembrane10
YMGF_ECOLIP58034
ymgF
b4520 JW1156 integral IM protein (SEC in IM), YmgFIntegral Inner Membrane PMID: 18978050Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN370.129TMH00.559611-22Ni12-31o37-59iCytoplasmicMembrane924
KDGL_ECOLIP0ABN1
dgkA
b4042 JW4002 integral IM protein (SEC in IM), Diacylglycerol kinase DgkAIntegral Inner Membrane PMID: 15919996 PMID: 2984194 PMID: 8071224Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN540.112CYT0-0.200913-23Ni30-51o57-80i100-121oCytoplasmicMembrane1031
DCUA_ECOLIP0ABN5
dcuA

genA

genAb4138 JW5735 integral IM protein (SEC in IM), Anaerobic C4-dicarboxylate transporter DcuAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN280.186TMH07.74612-1111No6-38i45-66o86-109i130-152o164-190i225-243o255-277i289-306o326-345i357-381o410-431iCytoplasmicMembrane10
DCUB_ECOLIP0ABN9
dcuB

genF

genFb4123 JW4084 integral IM protein (SEC in IM), Anaerobic C4-dicarboxylate transporter DcuBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN680.125TMH08.74519-1110Yn2-13c17/18o27-44i51-71o91-118i139-162o174-195i236-254o266-288i300-318o342-372i421-445oCytoplasmicMembrane10
DCUC_ECOLIP0ABP3
dcuC
b0621 JW0613/JW0616 integral IM protein (SEC in IM), Anaerobic C4-dicarboxylate transporter DcuCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECnoyesN560.117TMH00.537839-1212Ni5-22o28-46i79-98o118-144i156-175o195-218i238-260o266-288i309-333o339-363i406-424o436-458iCytoplasmicMembrane103
DEDA_ECOLIP0ABP6
dedA
b2317 JW2314 integral IM protein (SEC-YidC in IM) of DedA family, DedAIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC. Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF.PMID: 22108384 PMID: 15919996 PMID: 23086209Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN200.121CYT0-0.200913-44Ni27-49o69-92i156-178o190-208iCytoplasmicMembrane10
YOHJ_ECOLIP60632
yohJ
b2141 JW2129 integral IM protein (SEC in IM), UPF0299 YohJIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN300.138TMH013.9988-44Ni12-32o38-55i67-86o92-113iCytoplasmicMembrane1015
YBJM_ECOLIP64439
ybjM
b0848 JW0832 integral IM protein (SEC in IM), YbjMIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN340.187TMH012.0012-44Ni7-28o40-57i64-83o95-117iCytoplasmicMembrane1052
YCEO_ECOLIP64442
yceO
b1058 JW1045 integral IM protein (SEC in IM), YceOIntegral Inner Membrane Small membrane protein detected experimentally.PMID: 19121005Integral Inner MembraneBBinoutin/outIM (predicted)Membrane anchoredSRPSECnoyesN160.097CYT0-0.200913-11Ni25-45oCytoplasmicMembrane9
YIJE_ECOLIP0ABT8
yijE
b3943 JW5557 integral IM protein (SEC in IM), Probable cystine transporter YijE YijEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN300.12TMH07.7108-1010Ni12-29o35-59i71-91o97-118i125-141o153-171i183-205o217-239i246-266o272-289iCytoplasmicMembrane10
EXBB_ECOLIP0ABU7
exbB
b3006 JW2974 integral IM protein (SEC in IM), Biopolymer transport ExbBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.153CYT0-0.200913-33No21-43i132-157o177-198iCytoplasmicMembrane1014
TOLQ_ECOLIP0ABU9
tolQ

fii

fiib0737 JW0727 integral IM protein (SEC in IM), Tol-Pal system TolQ Integral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. PMID: 8300535 PMID: 8331075PMID: 9008159 PMID: 15919996 PMID: 8300535 PMID: 8331075Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRP (exp)SECyesyesN340.244TMH02.05597-33No15-35i139-159o171-192iCytoplasmicMembrane109
FLIP_ECOLIP0AC05
fliP

flaR

flaRb1948 JW1932 Flagellar integral IM protein (SEC in IM), biosynthetic FliPIntegral Inner Membrane A cleavable signal peptide is required for the full function of FliP protein.PMID: 15194505 PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinflagellumSRPSECnoyesY220.692TMH013.015-54Yn4-15c21/22o45-74i86-105o185-211i223-244oCytoplasmicMembrane10
FOCA_ECOLIP0AC23
focA

ycaE

ycaEb0904 JW0887 integral IM protein (SEC in IM), Probable formate transporter 1 FocAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN190.124TMH01.35944-66Ni35-55o75-98i118-141o161-180i192-212o255-277iCytoplasmicMembrane10
YNAJ_ECOLIP64445
ynaJ
b1332 JW1326 integral IM protein (SEC in IM), YnaJIntegral Inner MembraneBBoutin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN330.241TMH015.6597-21Yn15-26c31/32o55-80iCytoplasmicMembrane929
ORTT_ECOLIP64453
ortT

ydcX

ydcXb1445 JW5232 integral IM protein (SEC in IM), Orphan toxin OrtT Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN190.119TMH010.662-22No6-25i37-56oCytoplasmicMembrane9
YDHI_ECOLIP64471
ydhI
b1643 JW1635 integral IM protein (SEC in IM), YdhIIntegral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN320.128TMH010.2168-22No20-44i56-77oCytoplasmicMembrane943
YDJM_ECOLIP64481
ydjM
b1728 JW5281 integral IM protein (SEC in IM), YdjMIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN280.333CYT0-0.200913-04Yn7-17c22/23o32-48i69-90o110-128i149-166oCytoplasmicMembrane1015
NIRC_ECOLIP0AC26
nirC
b3367 JW3330 integral IM protein (SEC in IM), Nitrite transporter NirC NirCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN350.428TMH04.72286-66Ni25-47o59-80i101-126o146-169i181-206o226-248iCytoplasmicMembrane10
FTSX_ECOLIP0AC30
ftsX

ftsS

ftsSb3462 JW3427 integral IM protein (SEC in IM), Cell division FtsXIntegral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 3323846 PMID: 10048040 PMID: 14729705 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRP (exp)SECyesyesN390.105CYT0-0.200913-44No72-95i214-240o272-290i323-342oCytoplasmicMembrane1023
DHSD_ECOLIP0AC44
sdhD
b0722 JW0712 integral IM protein (SEC in IM), Succinate dehydrogenase hydrophobic anchor subunit SdhDIntegral Inner Membrane PArt of colisuccinate dehydrogenase (SQR) composed of two hydrophilic subunits, a flavoprotein (SdhA) and iron-sulfur protein (SdhB) subunit, and two hydrophobic membrane anchor subunits, SdhC and SdhD.PMID: 11266632 PMID: 12560550 PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN390.133TMH010.7371-33Ni17-39o59-80i92-113oCytoplasmicMembrane1044
KDTA_ECOLIP0AC75
waaA

kdtA

kdtAb3633 JW3608 integral IM protein (SEC in IM), 3-deoxy-D-manno-octulosonic acid transferase WaaAIntegral Inner Membrane Involved in lipopolysaccharide biosynthesis PMID: 2651435 PMID: 1577828. Embedded in the cytoplasmic face of the inner membrane, WaaA catalyzes the transfer of 3-deoxy-d-manno-oct-2-ulosonic acid (Kdo) to the lipid A precursor of LPS (in Aquifex aeolicus) PMID: 22474366.PMID: 2651435 PMID: 1577828 PMID: 15866922 PMID: 22474366 PMID: 19275539Integral Inner MembraneBBinout/inIM (predicted)Cell inner membrane CytoplasmicSRPSECyesyesN640.121CYT0-0.200913-01No6-23iUnknown215
YEAQ_ECOLIP64485
yeaQ
b1795 JW1784 integral IM protein (SEC in IM), UPF0410 YeaQIntegral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN180.108TMH015.2932-33No6-21i28-52o58-77iCytoplasmicMembrane10
YEBO_ECOLIP64499
yebO
b1825 JW1814 integral IM protein (SEC in IM), YebOIntegral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell membrane Membrane anchoredSRPSECyesyesN360.143CYT0-0.200913-11No12-32iUnknown246
MGRB_ECOLIP64512
mgrB

yobG

yobGb1826 JW1815 integral IM protein (SEC in IM), PhoP/PhoQ regulator MgrB Integral Inner Membrane Small membrane protein detected experimentally. Localization and bacterial two-hybrid studies suggest that MgrB resides in the inner-membrane and interacts directly with PhoQ.PMID: 19121005 PMID: 20041203Integral Inner MembraneBBinoutin/outN/ACell inner membrane PeriplasmicSECnoyesN220.24SpI2110.2239-10Yn6-17c21/22oCytoplasmicMembrane953
WECA_ECOLIP0AC78
wecA

rfe

rfeb3784 JW3758 integral IM protein (SEC in IM), Undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase WecAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN290.115CYT0-0.200913-1111No6-24i45-66o72-89i101-119o131-149i161-179o185-206i213-232o244-263i294-315o321-342iCytoplasmicMembrane10
GNTP_ECOLIP0AC94
gntP

yjiB

yjiBb4321 JW4284 integral IM protein (SEC in IM), High-affinity gluconate transporter GntPIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN430.178TMH07.17039-1312Ni7-23o29-49i61-79o99-132i139-157o177-201i222-249o261-280i301-320o340-373i380-402o422-446iCytoplasmicMembrane10
GNTU_ECOLIP0AC96
gntU
b4476 JW5686 integral IM protein (SEC in IM), Low-affinity gluconate transporter GntUIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECpseudogene (Ochman & Davalos, 2006)yesyesN310.139TMH010.5274-1312Ni5-22o28-47i59-80o100-128i140-163o175-197i226-250o262-282i303-320o340-373i385-408o428-445iCytoplasmicMembrane10
SATP_ECOLIP0AC98
satP

yaaH

yaaHb0010 JW0009 integral IM protein (SEC in IM), Succinate-acetate/proton symporter SatP Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN340.122TMH09.07966-66Ni12-31o37-56i63-84o96-116i123-143o149-169iCytoplasmicMembrane10
HEMY_ECOLIP0ACB7
hemY
b3802 JW3774 integral IM protein (SEC in IM), HemYIntegral Inner Membrane Trigger factor-sensitive aggregation.PMID: 19737520 PMID: 15919996Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRP,TFSECyesyesN230.235TMH010.5296-21Yn4-17c26/27o42-62iCytoplasmicMembrane1019
YEIS_ECOLIP64536
yeiS
b2145 JW5359 integral IM protein (SEC in IM), YeiSIntegral Inner MembraneB-IM (predicted)Membrane Integral Membrane ProteinSRPSECnoyesN240.124TMH02.78571-22No6-24i54-77oCytoplasmicMembrane957
YFGG_ECOLIP64545
yfgG
b2504 JW5399 integral IM protein (SEC in IM), YfgGIntegral Inner MembraneBBinoutin/outN/AMembrane Membrane anchoredSRPSECnoyesN410.141TMH03.8997-10Yn20-31c39/40oCytoplasmicMembrane9
AlaE_ECOLIP64550
alaE

ygaW

ygaWb2670 JW2645 integral IM protein (SEC in IM), L-alanine exporter AlaE Integral Inner Membrane PMID: 21531828Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN490.117TMH06.24909-44Ni12-36o42-62i82-104o110-131iCytoplasmicMembrane1012
LPXL_ECOLIP0ACV0
lpxL

htrB waaM

htrB waaMb1054 JW1041 integral IM protein (SEC in IM), Lipid A biosynthesis lauroyltransferase LpxLIntegral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN200.104TMH01.65586-12Ni12-30o36-52iCytoplasmicMembrane1011
LPXP_ECOLIP0ACV2
lpxP

ddg

ddgb2378 JW2375 integral IM protein (SEC-YidC in IM), Lipid A biosynthesis palmitoleoyltransferase LpxPIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384Integral Inner MembraneBBinout/inIM (predicted)Cell inner membrane Membrane anchoredSRPSEC-YidCyesyesN490.166TMH01.68704-11No20-46iCytoplasmicMembrane99
LAPA_ECOLIP0ACV4
LapA

yciS

yciSb1279 JW1271 integral IM protein (SEC in IM), polysaccharide assembly A LapAIntegral Inner Membrane YciS (LapA) possibly participates both in lateral elongation of peptidoglycan and septum formation.PMID: 24722986 C-terminal tagging with the alkaline phosphatase and green fluorescent protein in order to define the periplasmic or cytoplasmic locations of the C termini. PMID: 15919996 Heat shock protein involved in the assembly of LPS. In pull-down experiments, LapA and LapB co-purified with LPS, Lpt proteins, FtsH (protease), DnaK, and DnaJ (chaperones). PMID: 25403562PMID: 15919996 PMID: 25403562Integral Inner MembraneBBinoutout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN230.34TMH011.7404-21Yn4-16c21/22o45-67iCytoplasmicMembrane1036
YDGC_ECOLIP0ACX0
ydgC
b1607 JW1599 integral IM protein (SEC in IM), YdgCIntegral Inner Membrane Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996PMID: 15919996 PMID: 24688744 PMID: 16429150Integral Inner MembraneBBpolyin/out, out/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN220.169TMH03.73379-43Yn7-17c21/22o31-47i59-79o85-108iCytoplasmicMembrane1023
YEBS_ECOLIP0AD03
yebS
b1833 JW1822 integral IM protein (SEC in IM), Intertransport YebS Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN570.112CYT0-0.200913-88Ni66-84o120-141i162-179o185-208i266-291o311-339i360-378o384-406iCytoplasmicMembrane10
YQJE_ECOLIP64585
yqjE
b3099 JW3070 integral IM protein (SEC in IM), YqjEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN620.126CYT0-0.200913-22Ni50-76o82-104iCytoplasmicMembrane10
YHAH_ECOLIP64590
yhaH
b3103 JW3074 integral IM protein (SEC in IM), YhaHIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.122TMH08.08221-33No23-40i52-70o82-103iCytoplasmicMembrane108
YHAI_ECOLIP64592
yhaI
b3104 JW3075 integral IM protein (SEC in IM), YhaIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.264TMH00.961473-33Ni23-44o50-68i80-98oCytoplasmicMembrane1028
BTSS_ECOLIP0AD14
btsS

yehU

yehUb2126 JW5353 integral IM protein (SEC in IM), Sensor histidine kinase BtsSIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN220.144TMH06.36838-66Ni7-24o44-62i74-93o105-129i141-163o175-195iCytoplasmicMembrane102
YOHK_ECOLIP0AD19
yohK
b2142 JW2130 integral IM protein (SEC in IM), YohKIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN240.211TMH01.42711-64Yn7-18c23/24o33-52i91-112o132-162i206-230oCytoplasmicMembrane10
YEJM_ECOLIP0AD27
yejM

yejN

yejNb2188 JW2176 integral IM protein (SEC in IM), YejMIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN680.133TMH014.6981-55Ni21-39o51-73i85-103o135-157i169-191oCytoplasmicMembrane102
YFCA_ECOLIP0AD30
yfcA
b2327 JW2324 integral IM protein (SEC in IM), Probable transporter YfcA Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN540.218TMH011.5476-78Ni7-28o53-73i85-105o111-127i139-158o164-183i195-217o237-255iCytoplasmicMembrane10
PGPC_ECOLIP0AD42
pgpC

yfhB

yfhBb2560 JW5408 integral IM protein (SEC in IM), Phosphatidylglycerophosphatase C PgpCIntegral Inner Membrane Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 25403562Integral Inner MembraneBBinout/inIM (predicted)Cell inner membrane Membrane anchoredSRPSECYfgMnoyesN520.106CYT0-0.200913-11No36-54iCytoplasmicMembrane98
YHDU_ECOLIP64619
yhdU
b3263 JW3231 integral IM protein (SEC in IM), YhdUPotential Signal PeptideIntegral Inner MembraneBBinoutin/outIM (predicted)Cell inner membrane Membrane anchoredSRPSECnoyesN310.117TMH00.197917-10Yn7-18c30/31oCytoplasmicMembrane982
YHFU_ECOLIP64631
yhfU
b3378 JW5697 integral IM protein (SEC in IM), YhfUIntegral Inner MembraneBBinoutout/inN/AMembrane anchoredSRPSECnoyesN370.114CYT0-0.200913-11No47-69iUnknown290
HOFN_ECOLIP64634
hofN

yrfC

yrfCb3394 JW3357 integral IM protein (SEC in IM), DNA utilization HofNIntegral Inner MembraneBBoutin/outN/ACell inner membrane Membrane anchoredSRPSECyesyesN490.175TMH03.72613-11Ni21-40oCytoplasmicMembrane922
MRDA_ECOLIP0AD65
mrdA

pbpA

pbpAb0635 JW0630 integral IM protein (SEC in IM), PG D,D-transpeptidase MrdA Integral Inner Membrane PMID: 1103132 PMID: 15919657Integral Inner MembraneBBoutin/outIM (predicted), Soluble IM Fraction, Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN370.174CYT0-0.200913-11Ni21-40oCytoplasmicMembrane98
FTSI_ECOLIP0AD68
ftsI

pbpB

pbpBb0084 JW0082 integral IM protein (SEC in IM), PG D,D-transpeptidase FtsI Integral Inner Membrane The bulk of the molecule, except for the N-terminal membrane anchor region, protrudes into the periplasmic space, where it acts on murein. Localizes to potential division sites in filamentous cells. Interacts directly with FtsN and ZapA. The integral membrane FtsW protein and peptidoglycan synthase PBP3 form a subcomplex.PMID: 11703663 PMID: 20497333 PMID: 20847002Integral Inner MembraneBBoutin/outSoluble IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN370.141SpI453.45111-11Ni20-44oCytoplasmicMembrane922
BRNQ_ECOLIP0AD99
brnQ
b0401 JW0391 integral IM protein (SEC-YidC in IM), Branched-chain amino acid transport system 2 carrier BrnQIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN250.304TMH015.0757-1212Ni12-29o41-64i76-98o118-138i150-171o191-212i224-246o281-307i314-333o339-359i371-389o409-426iCytoplasmicMembrane10
GHOT_ECOLIP64646
ghoT

yjdO

yjdOb4559 JW5732 integral IM protein (SEC in IM), Toxin GhoT Integral Inner Membrane Toxin-antitoxin system Ghot-GhoS.In vitro RNA degradation studies, quantitative real-time reverse-transcription PCR and whole-transcriptome studies revealed that GhoS masks GhoT toxicity by cleaving specifically yjdO (ghoT) mRNA.PMID: 22941047Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN330.1TMH09.94204-22Ni7-26o32-56iCytoplasmicMembrane9
YQHA_ECOLIP67244
yqhA
b3002 JW2971 integral IM protein (SEC in IM), UPF0114 YqhAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell membrane Integral Membrane Protein (Experimental)SRPSECyesyesN320.15TMH06.53453-34No12-32i53-75o109-126i138-156oCytoplasmicMembrane1015
YOBD_ECOLIP67601
yobD
b1820 JW1809 integral IM protein (SEC in IM), UPF0266 YobDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.285TMH03.32601-23No6-24i45-62o68-87iCytoplasmicMembrane10
MDTJ_ECOLIP69212
mdtJ

ydgF

ydgFb1600 JW1592 integral IM protein (SEC in IM), Spermidine export MdtJ Integral Inner Membrane PMID: 15919996 PMID: 24688744Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.125TMH07.68505-43Yn3-13c21/22o31-52i59-80o86-102iCytoplasmicMembrane1036
LOLC_ECOLIP0ADC3
lolC

ycfU

ycfUb1116 JW5161 integral IM protein (SEC in IM), Lipoprotein-releasing system TM protein LolCIntegral Inner Membrane PMID: 15276320 PMID: 10783239Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN190.179TMH02.37377-45No25-48i269-290o310-336i343-360o366-385iCytoplasmicMembrane1029
LPTG_ECOLIP0ADC6
lptG

yjgQ

yjgQb4262 JW5760 integral IM protein (SEC in IM), polysaccharide export system permease LptG Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN360.105TMH04.7678-66Ni12-33o66-84i105-125o279-298i305-322o334-356iCytoplasmicMembrane109
YJJP_ECOLIP0ADD5
yjjP
b4364 JW5796 integral IM protein (SEC in IM), YjjPIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN280.178CYT0-0.200913-35Ni114-135o141-158i170-189o195-214i226-252oCytoplasmicMembrane1016
NEPI_ECOLIP0ADL1
nepI

yicM

yicMb3662 JW5938 integral IM protein (SEC in IM), Purine ribonucleoside efflux pump NepI NepIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN480.151TMH08.80109-1212Ni21-44o56-75i87-106o112-133i145-164o176-196i217-239o254-275i282-301o307-329i341-363o369-389iCytoplasmicMembrane10
YIGM_ECOLIP0ADP5
yigM
b3827 JW3803 integral IM protein (SEC in IM), Biotin transporter YigMIntegral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN200.164TMH06.74192-109Yn2-13c19/20o29-47i59-81o87-105i112-130o136-158i170-190o202-222i234-253o259-276iCytoplasmicMembrane10
PGAD_ECOLIP69432
pgaD

ycdP

ycdPb1021 JW1006 integral IM protein (SEC in IM), Biofilm PGA synthesis PgaDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN380.135TMH010.5144-22Ni16-36o56-74iCytoplasmicMembrane109
PTXB_ECOLIP69789
glvB

glvC

glvCb3682 JW3659 integral IM protein (SEC in IM), Phosphotransferase enzyme IIB component GlvB Integral Inner MembraneBBinout/inIM (predicted)Cell membrane Membrane anchoredSRPSECpseudogene (Ochman & Davalos, 2006)yesnoN450.17CYT0-0.200913-11No12-31iCytoplasmicMembrane933
AFUB_ECOLIP75681
afuB

fbpB

fbpBb0263 JW0255 integral IM protein (SEC in IM), Putative ferric transport system permease-like AfuB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoN460.154CYT0-0.200913-22Ni33-56o76-101iCytoplasmicMembrane930
YIID_ECOLIP0ADQ2
yiiD
b3888 JW3859 integral IM protein (SEC in IM), YiiDIntegral Inner Membrane Copurifies with trigger factor in pull down assays.PMID: 19737520Integral Inner MembraneBBinoutout/inIM (predicted)CytoplasmicSRP,TFSECnoyesN290.101CYT0-0.200913-01No219-240iCytoplasmic853
YQAA_ECOLIP0ADR0
yqaA
b2689 JW2664 integral IM protein (SEC in IM), YqaAIntegral Inner Membrane Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. PMID: 15919996PMID: 15919996 PMID: 23086209Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN190.233TMH05.40517-43Yn4-12c17/18o41-65i86-110o116-141iCytoplasmicMembrane104
YGDD_ECOLIP0ADR2
ygdD
b2807 JW2778 integral IM protein (SEC in IM), UPF0382 YgdDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.249TMH014.4685-43Yn7-20c24/25o40-61i68-91o97-121iCytoplasmicMembrane10
YGIM_ECOLIP0ADT8
ygiM
b3055 JW3027 integral IM protein (SEC in IM), YgiMIntegral Inner MembraneBBinoutout/inIM (predicted), Detected in IM FractionMembrane Membrane anchoredSRPSECyesyesY230.542SpI2218.2018-11Yn6-17c22/23o173-195iUnknown212
LPTC_ECOLIP0ADV9
lptC

yrbK

yrbKb3199 JW3166 integral IM protein (SEC in IM), polysaccharide export system LptC Integral Inner Membrane Echolocation says Signal peptide may be membrane anchored or cleaved and the protein therefore exported (signalP score near threshold)PMID: 18424520 PMID: 20720015Integral Inner MembraneBBoutin/outSoluble IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN260.212SpI257.46611-10Yn7-18c27/28oUnknown251
YHCB_ECOLIP0ADW3
yhcB
b3233 JW5539 integral IM protein (SEC in IM), YhcBIntegral Inner Membrane Has been isolated from inner membrane preparations in a complex with one subunit each of CydA and CydB, suggesting that YhcB is in fact a subunit of the cytochrome bd ubiquinol oxidase complex. YhcB was demonstrated to interact with RodZ as well as several other proteins involved in cell shape maintenance and an inner membrane protein YciS of unknown function, using bacterial two-hybrid system.These observations seem to indicate that YhcB is involved in the biogenesis of cell envelope and the maintenance of cell shape together with RodZ. <a href="http:/PMID: 16079137 PMID: 21210718 PMID: 15919657Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECnoyesN210.134CYT0-0.200913-11No6-24iCytoplasmicMembrane983
RCLC_ECOLIP75685
rclC

ykgB

ykgBb0301 JW5038 integral IM protein (SEC in IM), RclCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN410.117TMH00.0510112-34Ni12-32o87-105i112-133o153-175iCytoplasmicMembrane10
YBBV_ECOLIP75711
ybbV
b0510 JW0498 integral IM protein (SEC in IM), YbbVIntegral Inner MembraneBBinout/inIM (predicted)Membrane anchoredSRPSECnoyesN610.11CYT0-0.200913-11No15-33iUnknown2
PPID_ECOLIP0ADY1
ppiD

ybaU

ybaUb0441 JW0431 integral IM protein (SEC in IM), Peptidyl-prolyl cis-trans isomerase D PpiDIntegral Inner Membrane By in vivo and in vitro site-directed cross-linking, it has been demostrated that the periplasmic chaperone PpiD is located in front of the lateral gate of SecY, through which transmembrane domains exit the SecY channel. Blue native PAGE analyses verify the presence of a SecYEG-PpiD complex in native Escherichia coli membranes. PMID: 24951590 Consistent with a coupling between translocation across the SecYEG translocon and folding by periplasmic chaperones, a lack of PpiD retards the release of a translocating outer membrane protein into the periplasm. PMID: 18439025PMID: 16079137 PMID: 9670013 PMID: 24951590 PMID: 18439025Integral Inner MembraneBBoutin/outIM (predicted), Detected in IM FractionCell inner membrane Membrane anchored (Experimental)SRPSECyesyesN430.199TMH03.55242-11Ni12-35oCytoplasmicMembrane1052
YAJC_ECOLIP0ADZ7
yajC
b0407 JW0397 integral IM protein (SEC in IM), Sec translocon accessory complex subunit YajC Integral Inner Membrane Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338PMID: 16079137 PMID: 21541338Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN170.156TMH0-0.000234246-11No20-39iCytoplasmicMembrane1041
AMPE_ECOLIP0AE14
ampE
b0111 JW0107 integral IM protein (SEC in IM), AmpEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN230.115CYT0-0.200913-44Yn2-12c16/17o40-58i65-85o148-168i266-283oCytoplasmicMembrane103
AMPG_ECOLIP0AE16
ampG
b0433 JW0423 integral IM protein (SEC-YidC in IM), AmpGIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN380.305TMH012.6077-1414Ni15-38o44-61i82-101o107-131i143-165o177-195i225-250o262-281i288-309o321-342i354-376o382-402i423-445o465-485iCytoplasmicMembrane10
RZPD_ECOLIP75719
rzpD

ybcT

ybcTb0556 JW5079 integral IM protein (SEC in IM), Prophage Rz endopeptidase RzpD Integral Inner Membrane Required for normal curli ex<x>pression and biofilm development.PMID: 23378572Integral Inner MembraneB-N/APeriplasmicSRPSECProphage Integrase (EcoGene)nonoN230.233SpI223.631-10Yn6-17c22/23oUnknown228
YBHM_ECOLIP75769
ybhM
b0787 JW0770 integral IM protein (SEC in IM), YbhMIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN410.18TMH04.77792-77Ni21-41o53-70i77-98o104-129i136-155o161-179i209-229oCytoplasmicMembrane1067
ARAE_ECOLIP0AE24
araE
b2841 JW2809 integral IM protein (SEC-YidC in IM), Arabinose-proton symporter AraEIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN450.136TMH07.37397-1212Ni23-51o63-84i91-110o116-137i149-167o179-198i258-281o297-317i329-348o360-384i405-422o428-446iCytoplasmicMembrane10
ARAH_ECOLIP0AE26
araH
b4460 JW1887 integral IM protein (SEC-YidC in IM), L-arabinose transport system permease AraH Integral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCpseudogene (Ochman & Davalos, 2006)noyesN470.147TMH013.0464-910Ni21-42o54-72i79-96o102-124i131-150o170-191i222-240o252-269i276-295o301-317iCytoplasmicMembrane10
ARTM_ECOLIP0AE30
artM
b0861 JW0845 integral IM protein (SEC-YidC in IM), Arginine ABC transporter permease ArtMIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN270.106TMH012.0162-55No20-39i51-70o82-100i155-176o188-211iCytoplasmicMembrane10
ARTQ_ECOLIP0AE34
artQ
b0862 JW0846 integral IM protein (SEC-YidC in IM), Arginine ABC transporter permease ArtQIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN300.173TMH017.1037-45No12-35i42-68o101-118i161-182o202-223iCytoplasmicMembrane1026
YCAP_ECOLIP75839
ycaP
b0906 JW0889 integral IM protein (SEC in IM), UPF0702 transYcaP Integral Inner MembraneBBpolyout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN640.104TMH00.694512-33No18-37i49-69o75-96iCytoplasmic826
YCDZ_ECOLIP75916
ycdZ
b1036 JW5147 integral IM protein (SEC in IM), YcdZIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN650.232TMH014.4904-55No20-42i49-70o76-94i99-117o123-147iCytoplasmicMembrane10
YMFA_ECOLIP75962
ymfA
b1122 JW5164 integral IM protein (SEC in IM), YmfAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN290.212TMH06.47267-22Ni7-28o117-139iCytoplasmicMembrane10
YMFE_ECOLIP75968
ymfE
b1138 JW5166 integral IM protein (SEC in IM), YmfEIntegral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)nonoN370.102TMH01.7441-44Ni21-39o59-79i151-173o185-208iCytoplasmicMembrane107
YTFL_ECOLIP0AE45
ytfL
b4218 JW4177 integral IM protein (SEC in IM), UPF0053 YtfLIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.622SpI269.49148-43Yn5-18c26/27o56-80i100-119o139-162iCytoplasmicMembrane1048
CITT_ECOLIP0AE74
citT

ybdS

ybdSb0612 JW0604 integral IM protein (SEC in IM), Citrate/succinate antiporter CitTIntegral Inner Membrane PMID: 9696764Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN580.164TMH013.6692-1314Ni7-27o33-50i57-74o94-117i138-155o161-178i190-213o233-259i288-304o310-329i341-361o381-412i424-443o463-486iCytoplasmicMembrane10
CPXA_ECOLIP0AE82
cpxA

ecfB eup ssd

ecfB eup ssdb3911 JW3882 integral IM protein (SEC-YidC in IM), Sensor histidine kinase CpxAIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN190.111TMH01.20569-22No6-27i165-184oCytoplasmicMembrane1016
CYOE_ECOLIP0AEA5
cyoE
b0428 JW0418 integral IM protein (SEC in IM), Protoheme IX farnesyltransferase CyoEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN580.11TMH02.59686-99Ni12-30o36-60i80-102o108-127i134-156o162-183i209-227o233-252i264-285oCytoplasmicMembrane10
Y1142_ECOLIP75971
b1142
b1142 JW1128 integral IM protein (SEC in IM), Putative b1142 B114Integral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECpseudogene (Uniprot), pseudogene (Ecogene), pseudogene (Ochman & Davalos, 2006)nonoN630.119CYT0-0.200913-22Ni41-62o74-92iUnknown254
YMFR_ECOLIP75979
ymfR
b1150 JW1136 integral IM protein (SEC in IM), YmfRIntegral Inner MembraneBBinoutin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)nonoN220.153TMH011.0494-21Yn4-17c21/22o31-49iCytoplasmicMembrane916
YMGE_ECOLIP76011
ymgE

tag

tagb1195 JW1184 integral IM protein (SEC in IM), UPF0410 YmgEIntegral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN270.106TMH011.3901-33No6-21i28-47o59-81iCytoplasmicMembrane1016
YNBA_ECOLIP76090
ynbA
b1408 JW1405 integral IM protein (SEC in IM), YnbAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN500.126TMH0-0.193337-55No31-64i85-107o113-132i152-168o174-191iCytoplasmicMembrane1011
CYSW_ECOLIP0AEB0
cysW
b2423 JW2416 integral IM protein (SEC in IM), Sulfate transport system permease CysW Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.154TMH013.7791-66Ni20-43o63-89i101-124o144-162i202-228o248-268iCytoplasmicMembrane1052
YNAI_ECOLIP0AEB5
ynaI
b1330 JW1323 integral IM protein (SEC in IM), Low conductance mechanosensitive channel YnaI Integral Inner Membrane PMID: 22874652 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN220.127TMH07.65863-45No12-30i42-65o77-96i117-134o140-159iCytoplasmicMembrane1014
YOAE_ECOLIP0AEC0
yoaE
b1816 JW1805 integral IM protein (SEC in IM), UPF0053 YoaEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.115TMH01.99313-77No12-36i48-69o81-101i122-148o154-172i184-207o213-231iCytoplasmicMembrane1010
ARCB_ECOLIP0AEC3
arcB
b3210 JW5536 integral IM protein (SEC in IM), Aerobic respiration control sensor ArcBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN360.18TMH09.51619-22No20-46i58-77oCytoplasmicMembrane10
YDCZ_ECOLIP76111
ydcZ
b1447 JW1442 integral IM protein (SEC in IM), YdcZIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN610.165TMH08.79151-54Yn4-19c24/25o34-55i67-88o94-114i126-145oCytoplasmicMembrane1014
SAFA_ECOLIP76136
safA

yneN

yneNb1500 JW1494.1 integral IM protein (SEC in IM), Two-component-system connector SafA Integral Inner Membrane PMID: 17998538Integral Inner MembraneBBinout/inIM (predicted)Cell inner membrane -SRPSECnoyesN400.109CYT0-0.200913-11No19-40iCytoplasmicMembrane9
BARA_ECOLIP0AEC5
barA
b2786 JW2757 integral IM protein (SEC-YidC in IM), Signal transduction histidine-kinase BarAIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCnoyesN340.123TMH07.64299-22No12-31i177-199oCytoplasmicMembrane1056
DCUS_ECOLIP0AEC8
dcuS

yjdH

yjdHb4125 JW4086 integral IM protein (SEC-YidC in IM), Sensor histidine kinase DcuSIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCnoyesN480.105TMH05.80308-22Ni21-41o183-205iCytoplasmicMembrane1035
DPPB_ECOLIP0AEF8
dppB
b3543 JW3512 integral IM protein (SEC in IM), Dipeptide transport system permease DppBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.168TMH06.13051-66Ni9-30o100-123i135-160o201-221i259-285o305-331iCytoplasmicMembrane10
YNEE_ECOLIP76146
yneE
b1520 JW5245 integral IM protein (SEC in IM), UPF0187 YneEIntegral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN380.113TMH013.5444-34Ni28-46o52-70i208-229o235-255iCytoplasmicMembrane9
YNFA_ECOLIP76169
ynfA
b1582 JW1574 integral IM protein (SEC in IM), UPF0060 YnfAIntegral Inner Membrane Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996PMID: 11867724 PMID: 15919996 PMID: 24688744 PMID: 16429150Integral Inner MembraneBBpolyout/out, in/inIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN620.224TMH010.6101-44No6-26i33-54o60-78i85-105oCytoplasmicMembrane10
YDGK_ECOLIP76180
ydgK
b1626 JW1618 integral IM protein (SEC in IM), YdgKIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.147TMH019.3259-44Ni12-36o56-78i90-108o114-133iCytoplasmicMembrane10
DPPC_ECOLIP0AEG1
dppC
b3542 JW3511 integral IM protein (SEC-YidC in IM), Dipeptide transport system permease DppCIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN590.13TMH00.391748-55No32-53i102-127o147-173i215-244o264-287iCytoplasmicMembrane104
RSEP_ECOLIP0AEH1
rseP

ecfE yaeL

ecfE yaeLb0176 JW0171 integral IM protein (SEC in IM), Regulator of sigma-E protease RseP Integral Inner Membrane Fluorescent fusions of RseP have been monitored via fluorescence microscopy. RseP has been found to generally associated with the membrane.PMID: 17272300 PMID: 11689431 PMID: 11750129 PMID: 11867724 PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN330.109TMH03.00034-44No6-29i98-119o376-396i426-444oCytoplasmicMembrane1016
ELAB_ECOLIP0AEH5
elaB

yfbD

yfbDb2266 JW2261 integral IM protein (SEC in IM), ElaBIntegral Inner Membrane ElaB is an YqjD paralog and also has transmembrane motif at the C-terminal region. ElaB is an YqjD paralog and also has transmembrane motif at the C-terminal region. Probably binds to the membrane and ribosomes in a manner similar to that of YqjD PMID: 22661687.PMID: 22661687Integral Inner MembraneBBoutout/inIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN330.125CYT0-0.200913-11No81-99iUnknown299
EMRB_ECOLIP0AEJ0
emrB
b2686 JW2661 integral IM protein (SEC-YidC in IM), Multidrug export EmrB Integral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC. PMID: 15919996PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSEC-YidCyesyesN360.208TMH05.07213-1313Ni12-33o53-72i81-100o106-128i140-161o167-189i201-220o232-251i272-291o303-324i336-353o365-390i480-498oCytoplasmicMembrane10
YNIB_ECOLIP76208
yniB
b1726 JW1715 integral IM protein (SEC in IM), YniBIntegral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell membrane Integral Membrane ProteinSRPSECyesyesN440.107TMH05.0431-34No15-33i45-63o83-101i150-172oCytoplasmicMembrane1040
YNJA_ECOLIP76222
ynjA
b1753 JW1742 integral IM protein (SEC in IM), YnjAIntegral Inner MembraneBBinout/inIM (predicted)CytoplasmicSRPSECyesyesN260.102CYT0-0.200913-01No33-51iCytoplasmicMembrane941
YNJF_ECOLIP76226
ynjF
b1758 JW1747 integral IM protein (SEC in IM), YnjFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN430.114CYT0-0.200913-55No33-60i81-102o114-135i147-167o173-195iCytoplasmicMembrane10
ENVZ_ECOLIP0AEJ4
envZ

ompB perA tpo

ompB perA tpob3404 JW3367 integral IM protein (SEC in IM), Osmolarity sensor EnvZ Integral Inner Membrane Contains HAMP an intrinsically disordered domain. EnvZ HAMP domain by itself is unable to form a stable structure and that this structural fragility may be important for its role in signal transduction. PMID: 2668953 PMID: 15522865 PMID: 17635923 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.263TMH07.11037-22Ni12-39o160-179iCytoplasmicMembrane10
FDNI_ECOLIP0AEK7
fdnI
b1476 JW1472 integral IM protein (SEC in IM), Formate dehydrogenase, nitrate-inducible, cytochrome b556(Fdn) subunit FdnIIntegral Inner Membrane PMID: 15342602 PMID: 11266632 PMID: 11884747 PMID: 15919996 PMID: 11929547Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN370.156TMH022.1464-44Ni21-43o55-76i117-138o150-174iCytoplasmicMembrane1035
FDOI_ECOLIP0AEL0
fdoI
b3892 JW3863 integral IM protein (SEC in IM), Formate dehydrogenase, cytochrome b556(fdo) subunit FdoIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN290.115TMH016.4965-44Ni20-43o55-73i113-133o145-172iCytoplasmicMembrane1016
GALP_ECOLIP0AEP1
galP
b2943 JW2910 integral IM protein (SEC in IM), Galactose-proton symporter GalPIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN260.158TMH014.2152-1212Ni15-44o56-77i84-103o109-130i142-160o172-192i251-274o290-310i322-342o348-373i385-406o418-436iCytoplasmicMembrane10
YOAI_ECOLIP76239
yoaI
b1788 JW5885 integral IM protein (SEC in IM), YoaIIntegral Inner MembraneBBinoutout/inIM (predicted)Membrane -SRPSECnoyesN210.164CYT0-0.200913-11No6-30iCytoplasmicMembrane9
YEDR_ECOLIP76334
yedR
b1963 JW1946 integral IM protein (SEC in IM), YedRIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN230.118TMH00.40092-23No6-22i43-62o86-109iCytoplasmicMembrane1043
YFDY_ECOLIP76521
yfdY
b2377 JW2374 integral IM protein (SEC in IM), YfdYIntegral Inner MembraneBBpolyout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN280.123TMH019.5928-33No6-25i32-49o55-75iCytoplasmicMembrane1058
GLNP_ECOLIP0AEQ6
glnP
b0810 JW0795 integral IM protein (SEC in IM), Glutamine transport system permease GlnP Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.119TMH07.24978-35No23-42i54-78o90-113i125-144o190-209iCytoplasmicMembrane10
GLPF_ECOLIP0AER0
glpF
b3927 JW3898 integral IM protein (SEC in IM), Glycerol uptake facilitator GlpFIntegral Inner Membrane PMID: 11266632 PMID: 11039922 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN310.125TMH09.6263-66Ni12-34o46-79i86-108o145-166i178-202o230-251iCytoplasmicMembrane10
GLTJ_ECOLIP0AER3
gltJ
b0654 JW0649 integral IM protein (SEC in IM), Glutamate/aspartate import permease GltJIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN400.108TMH09.38551-55No24-50i71-88o108-127i179-199o211-233iCytoplasmicMembrane10
GLTK_ECOLIP0AER5
gltK
b0653 JW0648 integral IM protein (SEC in IM), Glutamate/aspartate import permease GltKIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN310.129TMH07.84867-55No20-44i65-83o95-112i153-178o198-219iCytoplasmicMembrane10
GLTS_ECOLIP0AER8
gltS

gltC

gltCb3653 JW3628 integral IM protein (SEC in IM), Sodium/glutamate symporter GltSIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN270.145CYT0-0.200913-911Yn7-18c26/27o36-52i72-90o96-119i126-148o160-184i215-239o245-268i275-297o303-323i335-357o369-394iCytoplasmicMembrane10
YFEZ_ECOLIP76538
yfeZ
b2433 JW2426 integral IM protein (SEC in IM), YfeZIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.118TMH01.95358-44Ni21-41o61-78i90-110o116-135iCytoplasmicMembrane1040
YQIJ_ECOLIP76657
yqiJ
b3050 JW3022 integral IM protein (SEC in IM), YqiJIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN390.125TMH03.14983-33Ni12-35o66-86i98-117oCytoplasmicMembrane1012
YZGL_ECOLIP76692
yzgL
b3427 JW3390 integral IM protein (SEC in IM), YzgLIntegral Inner MembraneBBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECpseudogene (Uniprot)nonoN230.127TMH017.4708-22Ni12-40o46-69iCytoplasmicMembrane1029
HDED_ECOLIP0AET5
hdeD

yhiA

yhiAb3511 JW3479 integral IM protein (SEC in IM), HdeDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.139TMH03.36767-66Ni23-42o48-69i76-97o103-124i136-155o161-187iCytoplasmicMembrane10
HISM_ECOLIP0AEU3
hisM
b2307 JW2304 integral IM protein (SEC in IM), Histidine transport system permease HisM Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN420.123TMH010.1822-43No20-45i57-79o200-221iCytoplasmicMembrane10
HYFE_ECOLIP0AEW1
hyfE
b2485 JW2470 integral IM protein (SEC in IM), Hydrogenase-4 component E HyfEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN540.165TMH04.55769-77No6-24i31-54o60-80i92-114o126-143i152-171o177-196iCytoplasmicMembrane10
KGTP_ECOLIP0AEX3
kgtP

witA

witAb2587 JW2571 integral IM protein (SEC in IM), Alpha-ketoglutarate permease KgtPIntegral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRP (exp)SECnoyesN90.105TMH02.8422-1212Ni21-42o62-84i96-116o122-139i160-183o195-214i244-266o278-299i311-331o337-360i372-393o405-423iCytoplasmicMembrane10
LIVH_ECOLIP0AEX7
livH
b3457 JW3422 integral IM protein (SEC in IM), High-affinity branched-chain amino acid transport system permease LivH Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN450.186TMH016.6878-88No20-39i46-64o70-89i105-122o158-175i204-230o242-270i282-301oCytoplasmicMembrane10
HOKE_ECOLIP77091
hokE

ybdY

ybdYb4415 JW5084 integral IM protein (SEC in IM), Toxic HokE Integral Inner Membrane Potentially toxic protein.PMID: 19121005Integral Inner MembraneBBinoutin/outN/ACell inner membrane Membrane anchoredSRPSECnoyesN200.132SpI242.84692-10Yn6-24c29/30oPeriplasmic951
YKGH_ECOLIP77180
ykgH
b0310 JW0302 integral IM protein (SEC in IM), YkgHIntegral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN450.104CYT0-0.200913-22Ni21-42o186-209iUnknown225
YAHC_ECOLIP77219
yahC
b0317 JW0309 integral IM protein (SEC in IM), YahCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN700.119TMH010.9451-45Yn4-15c23/24o33-49i61-80o86-104i109-127o133-152iCytoplasmicMembrane10
MARC_ECOLIP0AEY1
marC

ydeB ydeC

ydeB ydeCb1529 JW1522 integral IM protein (SEC in IM), UPF0056 MarCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN380.16TMH010.7793-55No12-32i44-62o68-89i151-172o192-214iCytoplasmicMembrane105
MDFA_ECOLIP0AEY8
mdfA

cmlA cmr

cmlA cmrb0842 JW0826 integral IM protein (SEC-YidC in IM), Multidrug transporter MdfA Integral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN320.122TMH06.20433-1212Ni15-33o53-72i84-103o109-130i142-164o170-188i221-246o258-275i287-308o314-335i347-367o379-399iCytoplasmicMembrane10
MODB_ECOLIP0AF01
modB

chlJ

chlJb0764 JW0747 integral IM protein (SEC in IM), Molybdenum transport system permease ModB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN340.137TMH08.18777-55No20-37i49-70o90-115i136-158o198-220iCytoplasmicMembrane1020
MOTB_ECOLIP0AF06
motB
b1889 JW1878 integral IM protein (SEC in IM), Motility B MotBIntegral Inner Membrane MotB has one membrane-spanning alpha-helix but the majority of the molecule is in the periplasmic space with a peptidoglycan-binding domain near its C-terminus PMID: 2447650PMID: 19364805 PMID: 23193105 PMID: 2447650 PMID: 12730325Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane Membrane anchored (Experimental)SRPSECyesyesN320.155CYT0-0.200913-11No28-47iCytoplasmicMembrane733
MURJ_ECOLIP0AF16
murJ

mviN yceN

mviN yceNb1069 JW1056 integral IM protein (SEC in IM), Lipid II flippase MurJIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN220.165SpI230.241812-1313No27-45i82-110o130-154i161-182o188-205i236-262o274-292i313-334o354-371i383-402o408-429i441-466o478-501iCytoplasmicMembrane10
ESSQ_ECOLIP77237
essQ

ydfS

ydfSb1556 JW5255 integral IM protein (SEC in IM), Prophage lysis S homolog EssQ Integral Inner MembraneBBinoutin/inIM (predicted)Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)yesnoN380.166CYT0-0.200913-21Yn7-15c20/21o36-58iUnknown217
YAFU_ECOLIP77354
yafU
b0218 JW0207 integral IM protein (SEC in IM), Putative YafUIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECpseudogene (Uniprot)nonoN390.16TMH01.65262-22Ni21-38o44-64iCytoplasmicMembrane1073
NARV_ECOLIP0AF32
narV
b1465 JW1460 integral IM protein (SEC in IM), Respiratory nitrate reductase 2 gamma chain NarVIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.114TMH010.9916-55No12-29i50-69o89-111i132-151o180-199iCytoplasmicMembrane10
YJBB_ECOLIP0AF43
yjbB
b4020 JW3980 integral IM protein (SEC in IM), YjbBIntegral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN240.13TMH01.33234-88Yn2-13c17/18o45-64i76-98o104-121i133-151o171-194i206-226o238-262i274-294oCytoplasmicMembrane104
GHXP_ECOLIP0AF52
ghxP

yjcD

yjcDb4064 JW4025 integral IM protein (SEC in IM), Guanine/hypoxanthine permease GhxP Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN590.114CYT0-0.200913-1313Ni29-49o55-74i81-101o107-129i141-165o171-195i202-220o256-280i301-321o333-350i357-378o390-416i428-448oCytoplasmicMembrane10
LPTF_ECOLIP0AF98
lptF

yjgP

yjgPb4261 JW4218 integral IM protein (SEC in IM), polysaccharide export system permease LptF Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN380.124CYT0-0.200913-66Ni16-39o59-76i97-119o268-289i296-316o328-348iCytoplasmicMembrane1013
NARX_ECOLIP0AFA2
narX

narR

narRb1222 JW1213 integral IM protein (SEC in IM), Nitrate/nitrite sensor NarX Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN470.224SpI334.68578-22Ni12-36o154-174iCytoplasmicMembrane1044
HOKB_ECOLIP77494
hokB

ydcB

ydcBb4428 JW5225 integral IM protein (SEC in IM), Toxic HokB Integral Inner Membrane Potentially toxic protein.PMID: 19121005Integral Inner MembraneBBinout/inN/ACell inner membrane Membrane anchoredSRPSECnoyesN260.105CYT0-0.200913-11No6-24iPeriplasmic942
YBDJ_ECOLIP77506
ybdJ
b0580 JW0569 integral IM protein (SEC in IM), YbdJIntegral Inner MembraneBBinoutin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN360.165TMH013.1416-21Yn7-25c33/34o49-70iCytoplasmicMembrane9
NFRB_ECOLIP0AFA5
nfrB
b0569 JW0558 integral IM protein (SEC in IM), Bacteriophage adsorption B NfrBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN200.134CYT0-0.200913-44No12-42i365-384o390-410i422-443oCytoplasmicMembrane107
NHAB_ECOLIP0AFA7
nhaB
b1186 JW1175 integral IM protein (SEC in IM), Na(+)/H(+) antiporter NhaB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN440.149TMH010.0118-1212No20-47i59-77o89-108i120-141o147-165i202-219o239-260i299-331o351-368i389-413o453-471i478-498oCytoplasmicMembrane10
NIKC_ECOLIP0AFA9
nikC
b3478 JW3443 integral IM protein (SEC in IM), Nickel transport system permease NikC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN250.156TMH010.244-66Ni12-32o75-100i121-148o177-196i203-222o242-260iCytoplasmicMembrane10
NUOA_ECOLIP0AFC3
nuoA
b2288 JW2283 integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit A NuoAIntegral Inner Membrane Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338PMID: 15919996 PMID: 21541338Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN440.182TMH012.5237-33No12-37i68-88o100-122iCytoplasmicMembrane1048
YAGL_ECOLIP77607
yagL
b0278 JW0272 integral IM protein (SEC in IM), YagLIntegral Inner MembraneBBoutin/outIM (predicted)CytoplasmicSRPSECProphage Integrase (EcoGene)nonoN320.112CYT0-0.200913-01Ni12-32oCytoplasmic813
YAHH_ECOLIQ2EEQ3
yahH
b0322 JW5893 integral IM protein (SEC in IM), Putative YahHMembrane anchored by EchoLOCATIONIntegral Inner MembraneB-N/AMembrane anchoredSECpseudogene (Uniprot), pseudogene (Ecogene)nonoN420.264CYT0-0.200913-00NiUnknown2
YNID_ECOLIQ2EES1
yniD
b4535 JW5911 integral IM protein (SEC in IM), YniDIntegral Inner Membrane Small membrane protein detected experimentally.PMID: 19121005Integral Inner MembraneBBinoutin/outIM (predicted)Membrane Membrane anchoredSRPSECnoyesN310.1TMH04.22082-10Yn14-26c30/31oCytoplasmicMembrane9
YOHO_ECOLIQ2EES6
yohO
b4542 JW5354 integral IM protein (SEC in IM), UPF0387 YohOIntegral Inner Membrane Small membrane protein detected experimentally PMID: 19121005Integral Inner MembraneBBinoutout/inN/ACell inner membrane Membrane anchoredSRPSECnoyesN260.149TMH04.51604-11No6-31iCytoplasmicMembrane9
NUOH_ECOLIP0AFD4
nuoH
b2282 JW2277 integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit H NuoHIntegral Inner Membrane PMID: 20732298 PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN330.139TMH07.32865-89Ni12-32o52-69i81-100o112-133i154-174o186-207i234-257o269-289i301-322oCytoplasmicMembrane10
NUOJ_ECOLIP0AFE0
nuoJ
b2280 JW2275 integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit J NuoJIntegral Inner Membrane PMID: 20732298 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN290.504TMH010.2272-54Yn3-14c18/19o28-49i56-74o94-112i133-158oCytoplasmicMembrane1082
NUOK_ECOLIP0AFE4
nuoK
b2279 JW2274 integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit K NuoKIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 20732298 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.166TMH08.16488-33No6-24i29-54o60-81iCytoplasmicMembrane10
NUOM_ECOLIP0AFE8
nuoM
b2277 JW2272 integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit M NuoMIntegral Inner Membrane PMID: 20732298 PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN590.116TMH06.38779-1414No6-23i30-48o77-103i115-134o140-159i180-199o219-244i256-274o286-307i314-333o345-363i383-405o417-440i461-481oCytoplasmicMembrane10
NUON_ECOLIP0AFF0
nuoN
b2276 JW2271 integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit N NuoNIntegral Inner Membrane PMID: 20732298 PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN610.262TMH09.81822-1414No6-28i35-55o75-93i105-122o128-147i159-181o201-226i238-259o271-290i297-316o328-351i371-394o406-426i447-470oCytoplasmicMembrane10
YPFN_ECOLIQ2EET2
ypfN
b4547 JW2457 integral IM protein (SEC in IM), UPF0370 YpfNIntegral Inner MembraneBBinout/inIM (predicted)Cell membrane Membrane anchoredSRPSECnoyesN260.107CYT0-0.200913-11No6-24iUnknown271
YTJA_ECOLIQ2M5U1
ytjA
b4568 JW5891 integral IM protein (SEC in IM), UPF0391 YtjAIntegral Inner MembraneBBinoutin/inN/ACell membrane Integral Membrane ProteinSRPSECnoyesN310.166TMH011.6664-21Yn4-14c19/20o29-49iCytoplasmicMembrane9
YOBH_ECOLIQ2MB16
yobH
b4536 JW5298 integral IM protein (SEC in IM), YobHSignal peptide predicted, single transmembrane helice predicted which would be removed upon signal peptide cleavage. Putative outer membrane or exported. Taxonomy: Klebsiella pneumoniae.Integral Inner MembraneBBoutin/outN/AMembrane anchoredSRPSECnoyesN340.169TMH05.54741-10Yn10-20c24/25oCytoplasmicMembrane957
NUPC_ECOLIP0AFF2
nupC

cru

crub2393 JW2389 integral IM protein (SEC in IM), Nucleoside permease NupC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN270.126TMH00.463943-89No6-23i30-48o87-108i167-187o193-212i242-271o277-298i341-361o381-399iCytoplasmicMembrane10
NUPG_ECOLIP0AFF4
nupG
b2964 JW2932 integral IM protein (SEC in IM), Nucleoside permease NupGIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN510.127TMH010.0497-1212Ni12-31o37-58i70-89o95-116i137-155o161-179i211-235o255-275i282-300o306-327i348-369o381-402iCytoplasmicMembrane10
OPPB_ECOLIP0AFH2
oppB
b1244 JW1236 integral IM protein (SEC in IM), Oligopeptide transport system permease OppB Integral Inner Membrane Opp-LacZ hybrid proteins were used to show that OppB, OppC and OppD are membrane-associated proteins. PMID: 2821267PMID: 15919996 PMID: 2821267Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN480.124TMH03.13181-66Ni12-30o100-121i133-161o173-192i228-254o274-300iCytoplasmicMembrane10
OPPC_ECOLIP0AFH6
oppC
b1245 JW1237 integral IM protein (SEC in IM), Oligopeptide transport system permease OppC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN640.213TMH00.755301-66Ni40-64o103-128i140-158o164-183i218-247o267-290iCytoplasmicMembrane10
SIRB2_ECOLIQ46755
ychQ

sirB2

sirB2b1213 JW1204 integral IM protein (SEC in IM), YchQIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN390.138TMH06.48818-44No6-28i40-61o73-93i105-123oCytoplasmicMembrane1025
YGFX_ECOLIQ46824
ygfX

cptA

cptAb2896 JW2864 integral IM protein (SEC in IM), YgfXIntegral Inner Membrane PMID: 22239607Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Membrane anchoredSRPSECyesyesN390.141TMH05.61025-12Ni12-32o38-54iCytoplasmicMembrane933
YQGA_ECOLIQ46831
yqgA
b2966 JW2934 integral IM protein (SEC in IM), YqgAIntegral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN200.108TMH03.98827-68No6-23i30-50o56-75i103-123o135-157i164-181o187-206i213-233oCytoplasmicMembrane10
YGIZ_ECOLIQ46867
ygiZ
b3027 JW2995 integral IM protein (SEC in IM), YgiZIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.138TMH04.05338-33Ni12-29o54-72i84-103oCytoplasmicMembrane1027
PERM_ECOLIP0AFI9
perM

yfgO

yfgOb2493 JW2478 integral IM protein (SEC in IM), Putative permease PerM Integral Inner MembraneBBpolyout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN410.135TMH020.7793-77No20-51i72-93o151-177i217-236o242-270i282-301o307-332iCytoplasmicMembrane1026
PITA_ECOLIP0AFJ7
pitA

pit

pitb3493 JW3460 integral IM protein (SEC in IM), Low-affinity inorganic phosphate transporter 1 PitAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN390.147TMH08.59981-109No12-32i52-76o96-116i123-143o155-177i208-227o233-255i379-402o474-494iCytoplasmicMembrane10
PNUC_ECOLIP0AFK2
pnuC
b0751 JW0734 integral IM protein (SEC in IM), Nicotinamide riboside transporter PnuC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN200.115TMH03.57186-67No22-40i47-65o71-88i109-139o159-178i185-205o211-226iCytoplasmicMembrane10
POTB_ECOLIP0AFK4
potB
b1125 JW1111 integral IM protein (SEC in IM), Spermidine/putrescine transport system permease PotB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.107TMH05.71787-67No6-26i54-78o90-108i120-138o144-163i184-214o242-262iCytoplasmicMembrane10
POTC_ECOLIP0AFK6
potC
b1124 JW1110 integral IM protein (SEC in IM), Spermidine/putrescine transport system permease PotC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN600.118TMH010.8409-66Ni12-30o64-86i98-122o128-151i172-195o230-252iCytoplasmicMembrane10
YQEJ_ECOLIQ46943
yqeJ
b2848 JW5455 integral IM protein (SEC in IM), YqeJIntegral Inner MembraneBBoutin/outN/AMembrane PeriplasmicSRPSECnoyesN280.216SpI276.43067-11Ni7-27oUnknown2
YQJK_ECOLIQ47710
yqjK
b3100 JW3071 integral IM protein (SEC in IM), YqjKIntegral Inner MembraneBBinoutin/outIM (predicted), Detected in IM FractionMembrane anchoredSRPSECyesyesN620.14CYT0-0.200913-11Ni47-65oUnknown230
LDRD_ECOLIQ6BF25
ldrD
b4453 JW5966 integral IM protein (SEC in IM), Small toxic polypeptide LdrDIntegral Inner Membrane Potentially toxic protein.PMID: 19121005Integral Inner MembraneBBinoutout/inIM (predicted)Cell inner membrane CytoplasmicSRPSECyesyesN210.155CYT0-0.200913-11No14-31iCytoplasmicMembrane9
LDRB_ECOLIQ6BF87
ldrB
b4421 JW5958 integral IM protein (SEC in IM), Small toxic polypeptide LdrBIntegral Inner Membrane Potentially toxic protein.PMID: 19121005Integral Inner MembraneBBinoutout/inIM (predicted)Cell inner membrane CytoplasmicSRPSECyesyesN210.121CYT0-0.200913-11No14-31iCytoplasmicMembrane9
POTI_ECOLIP0AFL1
potI
b0857 JW0841 integral IM protein (SEC in IM), Putrescine transport system permease PotI Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN260.124TMH014.5424-67Ni12-35o60-90i102-129o141-163i184-206o212-232i244-264oCytoplasmicMembrane10
PQIA_ECOLIP0AFL9
pqiA

pqi5A

pqi5Ab0950 JW0933 integral IM protein (SEC in IM), Intertransport PqiA Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN330.119CYT0-0.200913-88Ni53-76o96-122i142-160o166-185i257-277o304-329i350-371o377-400iCytoplasmicMembrane10
PSPB_ECOLIP0AFM9
pspB
b1305 JW1298 integral IM protein (SEC in IM), Phage shock B PspBIntegral Inner Membrane Defects in yidC and sec secretion induce psp operon. PMID: 14594846PMID: 14594846Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane; Single-pass membrane proteinMembrane anchoredSRPSECProphage Transposase (by homology to BL21)noyesN300.112CYT0-0.200913-11No6-24iCytoplasmicMembrane1062
YADH_ECOLIP0AFN6
yadH
b0128 JW0124 integral IM protein (SEC in IM), transport permease YadHIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN200.101TMH08.75539-67Yn4-9c14/15o24-46i58-84o104-132i139-164o170-191i203-221o227-248iCytoplasmicMembrane104
YADS_ECOLIP0AFP0
yadS
b0157 JW0153 integral IM protein (SEC in IM), UPF0126 YadSIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN230.24TMH02.68818-77No6-23i30-50o62-79i91-110o116-137i149-168o174-190iCytoplasmicMembrane10
YBHR_ECOLIP0AFP9
ybhR
b0792 JW5803 integral IM protein (SEC in IM), Probable multidrug ABC transporter permease YbhR Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN410.153CYT0-0.200913-66Ni21-41o173-197i218-243o255-277i284-302o345-363iCytoplasmicMembrane10
YMGG_ECOLIQ7DFV3
ymgG
b1172 JW5178 integral IM protein (SEC in IM), UPF0757 YmgGIntegral Inner Membrane Belongs to the UPF0757 family. PMID: 18192383 PMID: 17787032Integral Inner MembraneBBpolyin/inN/AMembrane anchoredSRPSECnoyesY230.871SpI2223.9513-20Yn5-16c22/23oUnknown298
YBHS_ECOLIP0AFQ2
ybhS
b0793 JW0777 integral IM protein (SEC in IM), Probable multidrug ABC transporter permease YbhS Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN670.102CYT0-0.200913-66Ni29-47o182-205i232-255o261-283i295-314o346-370iCytoplasmicMembrane107
DAUA_ECOLIP0AFR2
dauA

ychM

ychMb1206 JW5189 integral IM protein (SEC in IM), C4-dicarboxylic acid transporter DauAIntegral Inner Membrane PMID: 23278959 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN690.11CYT0-0.200913-119No33-53i60-80o100-118i130-152o172-198i210-231o278-300i358-388o408-438iCytoplasmicMembrane10
YCJO_ECOLIP0AFR7
ycjO
b1311 JW1304 integral IM protein (SEC in IM), ABC transporter permease YcjOIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.147TMH012.2234-65Yn14-25c30/31o77-98i110-130o163-189i210-233o265-283iCytoplasmicMembrane10
YDCV_ECOLIP0AFR9
ydcV
b1443 JW1438 integral IM protein (SEC in IM), ABC transporter permease YdcVIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN330.134TMH08.81303-66Ni12-33o71-91i103-127o133-153i189-212o232-256iCytoplasmicMembrane10
LSRD_ECOLIP0AFS1
lsrD

ydeZ

ydeZb1515 JW1508 integral IM protein (SEC in IM), Autoinducer 2 import system permease LsrDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN240.162TMH09.62635-99Yn9-17c23/24o33-56i63-82o88-110i117-140o160-181i212-234o240-260i267-286o292-310iCytoplasmicMembrane10
TQSA_ECOLIP0AFS5
tqsA

ydgG

ydgGb1601 JW1593 integral IM protein (SEC in IM), AI-2 transport TqsAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.372TMH08.36419-88Ni12-31o37-55i62-83o144-165i197-218o224-246i258-279o299-325iCytoplasmicMembrane10
YDIK_ECOLIP0AFS7
ydiK
b1688 JW1678 integral IM protein (SEC in IM), Putative transport YdiK Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN420.172TMH013.7653-99Ni12-31o37-53i65-86o160-179i191-208o214-235i247-271o277-295i307-334oCytoplasmicMembrane10
MEPM_ECOLIP0AFS9
mepM

yebA

yebAb1856 JW5304 integral IM protein (SEC in IM), Murein DD-endopeptidase MepM MepMIntegral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane CytoplasmicSRPSECyesyesN120.112CYT0-0.200913-11Ni21-39oUnknown233
YECS_ECOLIP0AFT2
yecS
b1918 JW1903 integral IM protein (SEC in IM), L-cystine transport system permease YecS Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECnoyesN700.103TMH08.62641-33No21-45i57-78o186-206iCytoplasmicMembrane104
YEJB_ECOLIP0AFU0
yejB
b2178 JW2166 integral IM protein (SEC in IM), ABC transporter permease YejBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.157TMH04.74055-66Ni9-30o135-156i168-194o224-247i282-309o329-355iCytoplasmicMembrane10
YFBS_ECOLIP0AFU2
yfbS
b2292 JW2289 integral IM protein (SEC in IM), transporter YfbSIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN210.196TMH07.38351-1010Ni5-22o28-45i57-83o95-124i136-155o175-195i470-493o513-538i550-568o588-608iCytoplasmicMembrane10
YIBH_ECOLIP0AFV0
yibH
b3597 JW3571 integral IM protein (SEC in IM), YibHIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinMembrane anchoredSRPSECyesyesN530.113TMH02.25888-21Yn3-13c18/19o28-49iCytoplasmicMembrane1023
YHID_ECOLIP0AFV2
yhiD

yhhE

yhhEb3508 JW5670 integral IM protein (SEC in IM), Putative magnesium transporter YhiD Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN550.254CYT0-0.200913-55No6-22i34-54o69-87i92-112o118-138iCytoplasmicMembrane1028
RSEA_ECOLIP0AFX7
rseA

mclA yfiJ

mclA yfiJb2572 JW2556 integral IM protein (SEC in IM), Anti-sigma-E factor RseAIntegral Inner Membrane Responce to stress complex RpoE-RseA-RseB. Overproduction of N-terminal domain of RseA alone was shown to inhibit ??E activity. RseC which is an inner membrane protein, positively modulates ??E activity. The periplasmic domain of RseA interacts with RseB while its cytoplasmic domain interacts with RpoE, thereby sequestering RpoE away from the transcription complex. Proteolysis of transmembrane and cytoplasmic portions of RseA by DegS frees the sigma(E) transcription factor. RseB protein, a known negative regulator, inhibits proteolysis by DegS in vitro by binding tightly to the periplasmic domain of RseA. PMID: 17360428 The N-terminal domain of RseA sequesters ??E in the cytoplasmic membrane, preventing its association with core RNA polymerase. The C-terminal domain of RseA interacts with RseB, a periplasmic protein. PMID: 11777003 Crystal structure of Escherichia coli sigmaE with the cytoplasmic domain of its anti-sigma RseA reveals that RseA functions by sterically occluding the two primary binding determinants on sigma(E) for core RNA polymerase. PMID: 12718891PMID: 9159523 PMID: 9159522 PMID: 12183369 PMID: 17360428 PMID: 11777003 PMID: 12718891Integral Inner MembraneB-IM (predicted-detected)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN620.226CYT0-0.200913-00NiUnknown259
SANA_ECOLIP0AFY2
sanA

yeiF

yeiFb2144 JW2132 integral IM protein (SEC in IM), SanAIntegral Inner Membrane Related to vancomycin resistance and when overexpressed, is able to complement the permeability defects of a vancomycin-susceptible mutant.PMID: 8550448Integral Inner MembraneBBoutin/outN/ACell inner membrane; Single-pass membrane proteinPeriplasmicSRPSECyesyesN230.14TMH06.95693-10Yn5-18c22/23oCytoplasmicMembrane1010
SBMA_ECOLIP0AFY6
sbmA
b0377 JW0368 integral IM protein (SEC in IM), Peptide antibiotic transporter SbmA Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN300.182TMH018.7145-88Ni12-30o58-78i85-112o140-164i206-227o239-263i309-326o332-353iCytoplasmicMembrane10
TRKH_ECOLIP0AFZ7
trkH
b3849 JW5576 integral IM protein (SEC in IM), Trk system potassium uptake TrkH Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)yesyesN410.127TMH06.71344-1011Ni12-32o38-57i69-90o136-163i184-204o241-262i274-294o331-363i396-417o423-444i456-481oCytoplasmicMembrane10
WZZE_ECOLIP0AG00
wzzE

wzz yifC

wzz yifCb3785 JW5601 integral IM protein (SEC in IM), ECA polysaccharide chain length modulation protein WzzEIntegral Inner Membrane PMID: 15919996 PMID: 16816184 PMID: 16199561Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN470.253TMH08.70367-22No31-50i323-342oCytoplasmicMembrane1019
SOHB_ECOLIP0AG14
sohB
b1272 JW1264 integral IM protein (SEC in IM), Probable protease SohB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane; Single-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.141CYT0-0.200913-21No12-32iCytoplasmicMembrane108
YIBN_ECOLIP0AG27
yibN
b3611 JW3586 integral IM protein (SEC in IM), YibNIntegral Inner Membrane PMID: 15919657Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionMembrane anchoredSRPSECyesyesN360.109CYT0-0.200913-11No12-30iUnknown248
RHTB_ECOLIP0AG34
rhtB

yigK

yigKb3824 JW5585 integral IM protein (SEC in IM), Homoserine/homoserine lactone efflux protein RhtBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane Protein (Experimental)SRPSECpseudogene (Ochman & Davalos, 2006)noyesN250.247TMH011.1132-54Yn7-18c23/24o39-65i116-138o144-168i188-205oCytoplasmicMembrane10
RHTC_ECOLIP0AG38
rhtC

yigJ

yigJb3823 JW5586 integral IM protein (SEC in IM), Threonine efflux protein RhtCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)yesyesN250.144TMH08.74493-66No6-26i38-63o69-87i119-140o152-174i186-204oCytoplasmicMembrane10
RMUC_ECOLIP0AG71
rmuC

yigN

yigNb3832 JW3809 integral IM protein (SEC in IM), DNA recombination RmuCIntegral Inner Membrane Based on the fact that RmuC is a DNA recombination enzyme we conluded that its N-terminus lays in the periplasm.PMID: 16011798Integral Inner MembraneBBinout/inN/ACytoplasmicSRPSECyesyesN290.536SpI281.08238-11No6-25iUnknown215
SECD_ECOLIP0AG90
secD
b0408 JW0398 integral IM protein (SEC in IM), translocase subunit SecD Integral Inner Membrane PMID: 16079137 PMID: 15919657 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN250.158TMH01.57163-66Ni7-25o453-472i477-497o503-524i545-571o577-605iCytoplasmicMembrane1036
SECF_ECOLIP0AG93
secF
b0409 JW0399 integral IM protein (SEC in IM), translocase subunit SecF Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN30.112TMH02.24012-66Ni24-43o142-163i170-191o197-217i248-266o272-297iCytoplasmicMembrane10
SECE_ECOLIP0AG96
secE

prlG

prlGb3981 JW3944 integral IM protein (SEC in IM), translocase subunit SecE Integral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRP (exp)SECyesyesN480.137TMH07.80526-33No16-36i43-61o95-119iCytoplasmicMembrane107
SECG_ECOLIP0AG99
secG
b3175 JW3142 integral IM protein (SEC in IM), Protein-export SecGIntegral Inner Membrane PMID: 15919657 PMID: 15919996Integral Inner MembraneBBinoutin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN290.153TMH011.5638-21Yn4-22c27/28o51-70iCytoplasmicMembrane1049
SECY_ECOLIP0AGA2
secY

prlA

prlAb3300 JW3262 integral IM protein (SEC in IM), translocase subunit SecY Integral Inner Membrane PMID: 15919996 PMID: 3004955Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN470.104CYT0-0.200913-1010Ni23-44o75-98i119-139o154-174i186-203o215-237i274-296o316-337i373-391o397-418iCytoplasmicMembrane10
UHPT_ECOLIP0AGC0
uhpT
b3666 JW3641 integral IM protein (SEC in IM), Hexose-6-phosphate:phosphate antiporter UhpTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN530.105TMH00.582302-1212Ni28-45o65-85i97-117o123-148i160-183o189-210i260-278o298-318i327-345o351-380i392-411o423-446iCytoplasmicMembrane10
SMP_ECOLIP0AGC7
ytjB

smp

smpb4387 JW4350 integral IM protein (SEC in IM), YtjBIntegral Inner Membrane Has an aminoterminal stop transfer or signal sequence hydrophobic region and a second hydrophobic region near the C-terminus that may function as a stop transfer sequence; The protein was shown to fractionate with the bacterial membrane. No processing of tPMID: 2684780Integral Inner MembraneBBinoutin/outIM (predicted)Cell inner membrane Membrane anchoredSRPSECpseudogene (Ochman & Davalos, 2006)nonoN300.128SpI307.66045-11Yn13-24c29/30o164-184iCytoplasmicMembrane1063
SSTT_ECOLIP0AGE4
sstT

ygjU

ygjUb3089 JW3060 integral IM protein (SEC in IM), Serine/threonine transporter SstT Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.148TMH07.50816-88Ni18-36o42-72i84-106o149-166i187-209o215-240i290-315o327-352iCytoplasmicMembrane1015
XYLE_ECOLIP0AGF4
xylE
b4031 JW3991 integral IM protein (SEC in IM), D-xylose-proton symporter XylEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN300.155TMH06.47202-1211Yn13-24c32/33o56-78i90-109o129-151i163-186o198-220i270-293o313-334i346-364o370-395i407-426o446-463iCytoplasmicMembrane10
YHHJ_ECOLIP0AGH1
yhhJ
b3485 JW5677 integral IM protein (SEC in IM), transport permease YhhJIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN410.231SpI401.57995-56Ni174-200o220-244i256-281o287-306i318-337o343-364iCytoplasmicMembrane106
SAPB_ECOLIP0AGH3
sapB
b1293 JW1286 integral IM protein (SEC in IM), Putrescine export system permease SapB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN280.197TMH016.0324-56Ni9-29o82-101i113-141o175-193i245-263o283-305iCytoplasmicMembrane109
SAPC_ECOLIP0AGH5
sapC
b1292 JW1285 integral IM protein (SEC in IM), Putrescine export system permease SapC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN510.132TMH05.59827-56Ni31-54o99-123i144-169o189-208i220-241o261-283iCytoplasmicMembrane1010
PSTC_ECOLIP0AGH8
pstC

phoW

phoWb3727 JW3705 integral IM protein (SEC in IM), Phosphate transport system permease PstC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN30.109TMH04.7509-66Ni21-43o75-100i112-143o163-186i227-249o282-304iCytoplasmicMembrane10
RBSC_ECOLIP0AGI1
rbsC
b3750 JW3729 integral IM protein (SEC in IM), Ribose import permease RbsC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN580.121TMH06.39117-810Ni23-43o49-68i75-93o99-119i126-144o170-190i221-240o252-270i275-292o298-316iCytoplasmicMembrane1018
XYLH_ECOLIP0AGI4
xylH
b3568 JW3540 integral IM protein (SEC in IM), Xylose transport system permease XylH Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN510.13TMH04.89182-1011Ni25-45o65-83i90-107o113-132i139-156o176-196i217-235o241-259i290-306o326-357i369-385oCytoplasmicMembrane10
UBIA_ECOLIP0AGK1
ubiA

cyr

cyrb4040 JW4000 integral IM protein (SEC in IM), 4-hydroxybenzoate octaprenyltransferase UbiAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN360.118TMH06.00125-77Ni23-40o46-70i99-132o152-182i210-229o235-252i273-289oCytoplasmicMembrane10
YHHT_ECOLIP0AGM0
yhhT
b3474 JW5680 integral IM protein (SEC in IM), Putative transport YhhT Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.162TMH05.38885-88Ni12-31o37-55i62-87o133-163i197-215o221-246i253-275o295-315iCytoplasmicMembrane104
YICG_ECOLIP0AGM2
yicG
b3646 JW3621 integral IM protein (SEC in IM), UPF0126 YicGIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN220.368CYT0-0.200913-77No6-23i30-52o64-82i89-109o115-136i148-167o173-191iCytoplasmicMembrane10
URAA_ECOLIP0AGM7
uraA
b2497 JW2482 integral IM protein (SEC in IM), Uracil permease UraAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN470.107TMH03.93213-1213Ni20-38o44-60i67-83o89-108i120-147o159-176i183-202o225-250i262-281o301-319i331-354o366-384i391-409oCytoplasmicMembrane10
XANP_ECOLIP0AGM9
xanP

yicE

yicEb3654 JW3629 integral IM protein (SEC in IM), Xanthine permease XanP Integral Inner Membrane PMID: 16096267 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN660.123CYT0-0.200913-1111No36-58i70-89o128-146i158-181o193-212i219-240o260-280i350-372o378-396i408-427o439-458iCytoplasmicMembrane109
PROP_ECOLIP0C0L7
proP
b4111 JW4072 integral IM protein (SEC in IM), Proline/betaine transporter ProPIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN410.105CYT0-0.200913-1212Ni41-59o65-86i98-116o122-146i167-186o198-217i257-278o298-318i327-346o352-376i388-411o417-438iCytoplasmicMembrane10
MSCS_ECOLIP0C0S1
mscS

yggB

yggBb2924 JW2891 integral IM protein (SEC in IM), Small-conductance mechanosensitive channel MscSIntegral Inner Membrane PMID: 11266632 PMID: 12446901 PMID: 16079137 PMID: 15919657 PMID: 15919996 PMID: 12767977 PMID: 12015316 PMID: 10202137Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN520.15TMH0-0.184901-33No24-45i65-85o97-125iCytoplasmicMembrane1042
EPTC_ECOLIP0CB39
eptC

cptA yijP

cptA yijPb3955 JW3927 integral IM protein (SEC in IM), Phosphoethanolamine transferase EptC Integral Inner Membrane PMID: 16079137Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN90.182TMH012.4414-55Ni20-39o45-63i70-91o120-139i151-169oCytoplasmicMembrane1026
UIDB_ECOLIP0CE44
uidB

gusB uidP

gusB uidPb1616 JW1608 integral IM protein (SEC in IM), Glucuronide carrier homolog UidBIntegral Inner Membrane PMID: 15919996 PMID: 15774881Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN610.197TMH05.96454-1212Ni12-35o41-60i81-101o113-136i148-170o182-201i230-257o263-284i296-316o322-343i376-393o405-427iCytoplasmicMembrane10
RCSC_ECOLIP0DMC5
rcsC
b2218 JW5917/JW5920 integral IM protein (SEC in IM), Sensor histidine kinase RcsCIntegral Inner Membrane Fusions of rcsC to phoA that resulted in PhoA+ strains demonstrated that RcsC is a transmembrane protein with a periplasmic N-terminal domain and cytoplasmic C-terminal domain.PMID: 15919996 PMID: 2404948Integral Inner MembraneBBinoutout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN360.159TMH03.16217-21Yn20-31c40/41o314-334iCytoplasmicMembrane10
PHNE2_ECOLIP0DP70
phnE

phnE2

phnE2b4104 JW4065 b4103integral IM protein (SEC in IM), Putative cryptic phosphonate transport system permease PhnE2 Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006), pseudogene (Uniprot)noyesN360.143TMH08.60214-66Ni12-33o75-99i120-143o179-197i206-224o230-250iCytoplasmicMembrane107
NARK_ECOLIP10903
narK
b1223 JW1214 integral IM protein (SEC in IM), Nitrate/nitrite transporter NarK Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN600.17TMH00.305282-1212Ni38-62o74-92i104-124o130-158i178-197o217-234i255-278o290-308i320-339o351-377i404-425o437-457iCytoplasmicMembrane10
UGPA_ECOLIP10905
ugpA
b3452 JW3417 integral IM protein (SEC in IM), sn-glycerol-3-phosphate transport system permease UgpA Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN390.107TMH013.7961-66Ni12-31o78-100i112-130o157-181i206-228o267-288iCytoplasmicMembrane10
UGPE_ECOLIP10906
ugpE
b3451 JW3416 integral IM protein (SEC in IM), sn-glycerol-3-phosphate transport system permease UgpE Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN440.2TMH09.6685-67Ni7-31o81-105i112-133o145-166i187-210o216-238i250-272oCytoplasmicMembrane1028
NARI_ECOLIP11350
narI

chlI

chlIb1227 JW1218 integral IM protein (SEC in IM), Respiratory nitrate reductase 1 gamma chain NarIIntegral Inner Membrane Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (nitrate reductase A; NarGHI) PMID: 12910261. Part of the nitrate reductase A (NarGHI) of Escherichia coli which is membrane anchored through the NarI subunit. NarH is the electron transfer subunit. PMID: 12910261 In vivo associations of Escherichia coli NarJ with a peptide of the first 50 residues of nitrate reductase catalytic subunit NarG. PMID: 19295650 When E. coli is grown anaerobically in the presence of high levels of nitrate, the respiratory chain that is formed is terminated by NarGHI otherwise known as the quinol nitrate oxidoreductase. PMID: 2674654 The heterotrimeric NarGHI has an ?????? structure encoded by narGHI respectively. The ?? and ?? subunits can be purified as a soluble NarGH dimer in the cytoplasm showing that these 2 subunits associate to form a stable subcomplex before association with the membrane ?? subunit. PMID: 3371362 PMID: 3053688PMID: 11266632 PMID: 12910261 PMID: 15919996 PMID: 19295650 PMID: 2674654 PMID: 3371362 PMID: 3053688Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN190.113TMH011.8819-55No6-26i47-69o89-109i129-148o179-198iCytoplasmicMembrane10
FUCP_ECOLIP11551
fucP
b2801 JW2772 integral IM protein (SEC in IM), L-fucose-proton symporter FucPIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN420.298TMH00.0692344-1212Ni21-41o61-85i92-111o117-134i155-177o210-228i262-282o294-315i327-345o351-373i385-405o411-431iCytoplasmicMembrane10
DAMX_ECOLIP11557
damX

yhfB

yhfBb3388 JW3351 integral IM protein (SEC in IM), Cell division DamXIntegral Inner Membrane Contain a SPOR Domain. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338PMID: 23290046 PMID: 19880599 PMID: 21541338Integral Inner MembraneBBinoutin/outIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECnoyesN680.101CYT0-0.200913-11Ni103-124oUnknown2
ARGO_ECOLIP11667
argO

yggA

yggAb2923 JW2890 integral IM protein (SEC in IM), Arginine exporter ArgOIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein(experimental)SRPSECyesyesN250.273TMH06.65864-66No6-26i38-61o67-88i109-127o147-170i182-199oCytoplasmicMembrane1018
CSRD_ECOLIP13518
csrD

yhdA

yhdAb3252 JW3221 integral IM protein (SEC in IM), RNase E specificity factor CsrD Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN330.172TMH05.84825-22Ni7-31o130-155iCytoplasmicMembrane94
NHAA_ECOLIP13738
nhaA

ant

antb0019 JW0018 integral IM protein (SEC in IM), Na(+)/H(+) antiporter NhaA Integral Inner Membrane Structure of a Na+/H+ antiporter. A negatively charged ion funnel opens to the cytoplasm and ends in the middle of the membrane at the putative ion-binding site PMID: 15988517.PMID: 11266632 PMID: 15988517 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN340.227TMH07.93195-1111Ni12-39o59-79i91-114o126-145i154-175o181-200i207-238o258-276i288-312o324-351i363-380oCytoplasmicMembrane10
PROW_ECOLIP14176
proW
b2678 JW2653 integral IM protein (SEC-YidC in IM), Glycine betaine/proline betaine transport system permease ProW Integral Inner Membrane PMID: 10949305 PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN240.12CYT0-0.200913-66No97-118i125-143o149-171i192-219o271-291i303-320oCytoplasmicMembrane105
ZRAS_ECOLIP14377
zraS

hydH

hydHb4003 JW3967 integral IM protein (SEC in IM), Sensor ZraSIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN440.129TMH07.59471-22Ni12-35o202-222iCytoplasmicMembrane10
FECD_ECOLIP15029
fecD
b4288 JW4248 integral IM protein (SEC in IM), Fe(3+) dicitrate transport system permease FecDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN280.121TMH010.0321-77Yn4-19c31/32o55-76i85-103o109-126i138-158o226-256i268-290o296-315iCytoplasmicMembrane104
FECC_ECOLIP15030
fecC
b4289 JW4249 integral IM protein (SEC in IM), Fe(3+) dicitrate transport system permease FecCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.15TMH07.31223-89Yn8-27c36/37o60-81i93-111o117-140i152-171o177-194i201-220o240-270i282-304o310-328iCytoplasmicMembrane10
CSTA_ECOLIP15078
cstA

ybdC

ybdCb0598 JW0590 integral IM protein (SEC-YidC in IM), Peptide transporter CstA Integral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN210.185TMH08.48745-1816Ni7-26o32-52i93-111o117-138i159-185o191-209i221-240o260-277i284-305o325-345i373-393o470-494i515-534o546-571i578-598o648-671iCytoplasmicMembrane10
FLK_ECOLIP15286
flk

div

divb2321 JW2318 integral IM protein (SEC in IM), regulator Flk Integral Inner MembraneBBoutout/inIM (predicted)Cell inner membrane Membrane anchoredSRPSECyesyesN540.104CYT0-0.200913-11No313-330iCytoplasmicMembrane961
DHG_ECOLIP15877
gcd
b0124 JW0120 integral IM protein (SEC in IM), Quinoglucose dehydrogenase GcdIntegral Inner Membrane PMID: 16079137 PMID: 15919996 PMID: 8509415 PMID: 8419307 PMID: 8554505Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN430.121TMH021.0845-55Ni12-35o41-58i65-81o87-106i113-140oCytoplasmicMembrane918
AROP_ECOLIP15993
aroP
b0112 JW0108 integral IM protein (SEC-YidC in IM), Aromatic amino acid transport AroPIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN440.121TMH09.5384-1212Ni20-41o47-63i84-105o125-142i154-176o196-220i241-263o283-300i332-353o359-379i400-422o428-446iCytoplasmicMembrane10
PANF_ECOLIP16256
panF
b3258 JW3226 integral IM protein (SEC in IM), Sodium/pantothenate symporter PanFIntegral Inner Membrane Prediction of one very weak transmembrane region.PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN240.187TMH08.73514-1313No6-24i45-63o75-94i122-144o156-178i190-213o233-253i273-298o318-341i369-386o392-417i424-442o448-466iCytoplasmicMembrane10
HYCC_ECOLIP16429
hycC

hevC

hevCb2723 JW2693 integral IM protein (SEC in IM), Formate hydrogenlyase subunit 3 HycCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN320.168TMH011.9962-1416No6-26i33-58o78-96i108-124o130-146i153-173o197-218i230-251o257-280i292-312o332-349i370-395o415-435i456-480o500-521i587-605oCytoplasmicMembrane10
HYCD_ECOLIP16430
hycD

hevD

hevDb2722 JW2692 integral IM protein (SEC in IM), Formate hydrogenlyase subunit 4 HycDIntegral Inner Membrane PMID: 1625581 PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN300.198CYT0-0.200913-88No6-27i62-85o97-119i131-149o169-188i224-242o248-273i285-306oCytoplasmicMembrane10
CYST_ECOLIP16701
cysU

cysT

cysTb2424 JW2417 integral IM protein (SEC-YidC in IM), Sulfate transport system permease CysT Integral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN370.285TMH014.8684-75No12-37i58-84o104-125i137-156o242-263iCytoplasmicMembrane10117
MREC_ECOLIP16926
mreC
b3250 JW3219 integral IM protein (SEC in IM), Cell shape-determining MreCIntegral Inner Membrane PMID: 15612918Integral Inner MembraneBBoutin/outIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECnoyesN250.114TMH02.1577-10Yn15-23c28/29oUnknown235
PTQC_ECOLIP17334
chbC

celB

celBb1737 JW1726 integral IM protein (SEC-YidC in IM), PTS system N,N'-diacetylchitobiose-specific EIIC component ChbCIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN280.124CYT0-0.200913-1010Ni35-55o86-107i114-133o145-167i187-207o235-258i301-320o332-352i359-384o404-429iCytoplasmicMembrane105
CYNX_ECOLIP17583
cynX
b0341 JW0332 integral IM protein (SEC-YidC in IM), Cyanate transport CynXIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCnoyesN550.147CYT0-0.200913-1211Yn2-10c18/19o34-55i67-85o91-113i125-147o153-173i201-224o230-251i263-281o287-309i321-339o354-372iCytoplasmicMembrane10
PGPA_ECOLIP18200
pgpA

yajN

yajNb0418 JW0408 integral IM protein (SEC in IM), Phosphatidylglycerophosphatase A PgpAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN450.137TMH013.1049-35Ni21-51o57-75i87-104o110-126i138-162oCytoplasmicMembrane1023
RSTB_ECOLIP18392
rstB

uspT

uspTb1609 JW1601 integral IM protein (SEC in IM), Sensor RstBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN320.112TMH02.20306-22No6-27i136-157oCytoplasmicMembrane1053
DMSC_ECOLIP18777
dmsC
b0896 JW0879 integral IM protein (SEC in IM), Anaerobic dimethyl sulfoxide reductase chain C DmsCIntegral Inner Membrane DMSO reductase subunit C,Periplasmic. Has a membrane bound anchor. Part of the anaerobic dimethylsulphoxide (DMSO) reductase DmsABC. The DmsC polypeptide is composed of eight segments of hydrophobic amino acids of appropriate length to cross the cytoplasmic membrane, suggesting that this subunit functions to anchor the DMSO enzyme to the membrane. PMID: 3062312 There are contradictory experiments although it seems that the senario of the DmsABC complex facing the cytoplasm is more favoured. PMID: 11389150 The localization of DmsAB was compared in a strain expressing a partial DmsC subunit (pDMSC59X) with full-length DmsC originating from the chromosomal copy of the dms operon. In those experiments some DmsAB was reported in the periplasm in the absence of full-length DmsC, leading us to suggest that DmsC might serve a stop-transfer role. PMID: 9546395 TTnphoA fusions, and electron paramagnetic resonance monitoring the effects of the probe dysprosium(III) on an engineered 3Fe4S cluster in DmsB indicated that DmsAB faces the cytoplasm PMID: 2170332 PMID: 15919996PMID: 15919996 PMID: 3062312 PMID: 11389150 PMID: 9546395 PMID: 2170332Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN220.177TMH013.558-88No12-32i44-68o88-105i117-137o149-171i183-203o223-243i255-277oCytoplasmicMembrane10
PTOCB_ECOLIP19642
malX
b1621 JW1613 integral IM protein (SEC in IM), PTS system maltose-specific EIICB component MalXIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN440.116TMH07.8693-810Ni21-42o62-89i96-116o136-161i182-205o295-313i320-337o343-362i369-391o397-419iCytoplasmicMembrane105
TOLA_ECOLIP19934
tolA

cim excC lky

cim excC lkyb0739 JW0729 integral IM protein (SEC in IM), Tol-Pal system TolA Integral Inner Membrane The N-terminal coiled coil of YbgFvforms a stable trimer and controls the oligomeric status of YbgF. The stable YbgF trimer undergoes a marked change in oligomeric state on binding TolA, forming a one-to-one complex with the Tol protein. PMID: 7744737 Disulfide bridge (363 388) Disulfide bond-containing protein PMID: 25664544PMID: 15919657 PMID: 20816983 PMID: 7744737 PMID: 25664544Integral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane Membrane anchored (Experimental)SRPSECyesyesN430.131CYT0-0.200913-11Ni12-31oUnknown250
PTFBC_ECOLIP20966
fruA

ptsF

ptsFb2167 JW2154 integral IM protein (SEC in IM), PTS system fructose-specific EIIB'BC component FruAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN200.169CYT0-0.200913-99Ni230-256o268-291i303-329o349-368i389-410o430-451i463-482o488-507i519-551oCytoplasmicMembrane107
GLTP_ECOLIP21345
gltP
b4077 JW4038 integral IM protein (SEC in IM), Proton/glutamate-aspartate symporter GltPIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN310.123TMH011.2813-1010Ni7-27o47-72i84-106o160-181i202-224o236-264i293-311o323-350i362-385o391-409iCytoplasmicMembrane1019
YCIC_ECOLIP21365
yciC
b1255 JW1247 integral IM protein (SEC in IM), UPF0259 YciCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN470.196TMH06.50025-66Ni20-41o77-104i116-136o142-166i187-212o218-239iCytoplasmicMembrane10
YCAD_ECOLIP21503
ycaD
b0898 JW0881 integral IM protein (SEC in IM), MFS-type transporter YcaD Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.154TMH014.4924-1211Yn10-18c23/24o47-65i74-92o98-119i131-149o161-181i202-223o235-253i265-283o289-311i323-345o351-369iCytoplasmicMembrane10
KDPD_ECOLIP21865
kdpD
b0695 JW0683 integral IM protein (SEC in IM), Sensor KdpDIntegral Inner Membrane PMID: 1532388 PMID: 21605551 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECnoyesN460.149CYT0-0.200913-44Ni399-419o425-443i448-465o477-498iCytoplasmicMembrane1022
LIVM_ECOLIP22729
livM
b3456 JW3421 integral IM protein (SEC in IM), High-affinity branched-chain amino acid transport system permease LivM Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN210.39SpI2011.5293-1010Yn9-20c25/26o44-61i91-108o114-132i137-156o162-184i191-209o262-283i313-336o348-373i385-403oCytoplasmicMembrane10
TNAB_ECOLIP23173
tnaB

trpP

trpPb3709 JW5619/JW5622 integral IM protein (SEC in IM), Low affinity tryptophan permease TnaBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN250.14TMH016.6914-1111Ni12-32o38-61i82-105o125-143i155-174o194-219i226-246o282-310i322-341o347-369i381-406oCytoplasmicMembrane105
MGLC_ECOLIP23200
mglC
b2148 JW2135 integral IM protein (SEC in IM), Galactoside transport system permease MglC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.106TMH05.37465-98Ni12-31o43-64i105-129o135-155i175-201o227-248i269-299o311-330iCytoplasmicMembrane10
HYFB_ECOLIP23482
hyfB

yffF

yffFb2482 JW2467 integral IM protein (SEC in IM), Hydrogenase-4 component B HyfBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECnoyesN570.166TMH07.57984-1616No6-27i39-62o82-103i110-129o135-154i166-185o205-224i245-267o273-296i303-326o332-363i383-405o425-452i473-496o532-551i652-671oCytoplasmicMembrane10
FECR_ECOLIP23485
fecR
b4292 JW4252 integral IM protein (SEC in IM), FecRIntegral Inner Membrane The protein is oriented such that residues 1 to 85 are in the cytoplasm, residues 86 to 100 form a transmembrane segment, and residues 101 to 317 are in the periplasm where the C-terminus can interact with the N-domain of the outer membrane protein FecA.PMID: 9573190 PMID: 12057967Integral Inner MembraneB-IM (predicted-detected)PeriplasmIntegral Membrane ProteinSRPSECnoyesN350.136CYT0-0.200913-00NiPeriplasmic10
PHOQ_ECOLIP23837
phoQ
b1129 JW1115 integral IM protein (SEC in IM), Sensor PhoQIntegral Inner Membrane PMID: 23359663 PMID: 15919996 Integral Inner MembraneBBinout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN230.287TMH06.14229-21Yn17-28c33/34o194-216iCytoplasmicMembrane1020
PDEA_ECOLIP23842
pdeA

yfeA

yfeAb2395 JW5391 integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN450.113TMH09.46751-89No12-31i43-61o81-104i125-143o163-186i214-232o238-255i262-279o291-312iCytoplasmicMembrane10
TRKG_ECOLIP23849
trkG
b1363 JW1358 integral IM protein (SEC in IM), Trk system potassium uptake TrkG Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)yesnoN320.135TMH011.2875-1111Ni12-34o40-60i72-93o139-164i185-206o239-263i275-296o336-356i399-418o424-446i458-483oCytoplasmicMembrane10
FEPD_ECOLIP23876
fepD
b0590 JW0582 integral IM protein (SEC in IM), Ferric enterobactin transport system permease FepD Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN510.205TMH01.30983-99No6-30i64-81o93-114i121-139o151-172i193-213o239-264i284-304o310-326iCytoplasmicMembrane10
FEPG_ECOLIP23877
fepG
b0589 JW0581 integral IM protein (SEC in IM), Ferric enterobactin transport system permease FepG Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN230.416TMH010.9363-88Yn8-23c41/42o65-83i95-112o118-138i145-167o187-211i236-262o274-296i303-324oCytoplasmicMembrane10
CYDC_ECOLIP23886
cydC

mdrA mdrH surB

mdrA mdrH surBb0886 JW0869 integral IM protein (SEC in IM), ATP-binding/permease CydCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN500.199TMH016.2776-66Ni16-35o41-61i133-155o161-182i243-266o278-301iCytoplasmicMembrane1010
CADC_ECOLIP23890
cadC
b4133 JW4094 nucleoid & integral IM protein (SEC in IM), Transcriptional activator CadCIntegral Inner Membrane, NucleoidMembrane-integrated pH sensor. The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP.PMID: 23138451 PMID: 24056175 PMID: 21890895 PMID: 18086202Integral Inner Membrane, NucleoidB, NIM (predicted)Cell membrane Membrane anchoredSRPSECnoyesN500.131CYT0-0.200913-11No159-181iCytoplasmicMembrane9
HTPX_ECOLIP23894
htpX
b1829 JW1818 integral IM protein (SEC in IM), Protease HtpXIntegral Inner Membrane PMID: 12081643 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN350.141TMH012.8648-43Yn4-18c23/24o33-53i158-178o193-217iCytoplasmicMembrane108
EMRE_ECOLIP23895
emrE

eb mvrC

eb mvrCb0543 JW0531 integral IM protein (SEC-YidC in IM), Multidrug transporter EmrE Integral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC. Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996PMID: 22108384 PMID: 15919996 PMID: 24688744 PMID: 22178925 PMID: 16429150 PMID: 20508091 PMID: 22444835Integral Inner MembraneBBpolyin/out, out/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSEC-YidCProphage Integrase (EcoGene), pseudogene (Ochman & Davalos, 2006)nonoN620.162TMH06.32256-43No30-48i60-79o85-104iCytoplasmicMembrane107
ARAJ_ECOLIP23910
araJ
b0396 JW0386 integral IM protein (SEC in IM), Putative transporter AraJ Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN190.21TMH04.92502-1211Yn4-15c20/21o44-63i70-96o102-120i127-150o156-178i199-219o225-251i263-284o290-310i331-350o356-375iCytoplasmicMembrane10
LNT_ECOLIP23930
lnt

cutE

cutEb0657 JW0654 integral IM protein (SEC in IM), ApoN-acyltransferase LntIntegral Inner Membrane PMID: 2032623 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN280.184TMH013.3696-68Ni12-28o34-50i57-79o91-112i124-142o162-188i195-214o489-507iCytoplasmicMembrane102
ENTS_ECOLIP24077
entS

ybdA

ybdAb0591 JW0583 integral IM protein (SEC in IM), Enterobactin exporter EntSIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.337TMH010.2914-1112Ni21-42o54-74i86-105o111-135i147-170o176-199i219-246o258-276i288-305o311-336i357-374o380-399iCytoplasmicMembrane10
ACRD_ECOLIP24177
acrD

yffA

yffAb2470 JW2454 integral IM protein (SEC-YidC in IM), Probable aminoglycoside efflux pump AcrDIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN350.15SpI345.86063-1111Yn10-21c26/27o340-359i366-387o393-413i438-458o470-497i538-558o873-890i897-917o923-944i972-992o1004-1026iCytoplasmicMembrane10
ACRF_ECOLIP24181
acrF

envD

envDb3266 JW3234 integral IM protein (SEC in IM), Multidrug export AcrF Integral Inner Membrane PMID: 11274125 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN270.286SpI2612.2125-1211Yn10-21c26/27o340-359i366-390o396-416i437-458o470-497i541-558o872-891i898-918o924-948i969-990o1002-1028iCytoplasmicMembrane10
LPXM_ECOLIP24205
lpxM

msbB

msbBb1855 JW1844 integral IM protein (SEC in IM), Lipid A biosynthesis myristoyltransferase LpxMIntegral Inner MembraneBBinout/inIM (predicted)Cell inner membrane Membrane anchoredSRPSECyesyesN450.121CYT0-0.200913-11No24-43iCytoplasmicMembrane1016
PHEP_ECOLIP24207
pheP
b0576 JW0565 integral IM protein (SEC in IM), Phenylalanine-specific permease PhePIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN530.106TMH01.83401-1212Ni30-49o55-71i107-130o136-156i163-184o204-228i249-271o291-308i340-361o367-387i408-428o434-452iCytoplasmicMembrane10
PTIBC_ECOLIP24241
ascF
b2715 JW5435 integral IM protein (SEC-YidC in IM), PTS system arbutin-, cellobiose-, and salicin-specific EIIBC component AscFIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCnoyesN250.128CYT0-0.200913-810Ni104-127o147-167i179-197o217-234i254-282o288-309i330-350o362-382i389-413o433-456iCytoplasmicMembrane107
TEHA_ECOLIP25396
tehA
b1429 JW1425 integral IM protein (SEC in IM), Tellurite resistance TehA Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.119TMH012.0389-810Ni12-31o43-64i76-97o103-121i141-160o166-184i196-218o230-249i256-274o286-310iCytoplasmicMembrane10
GABP_ECOLIP25527
gabP
b2663 JW2638 integral IM protein (SEC in IM), GABA permease GabPIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.302TMH08.50646-1212Ni21-40o46-66i97-118o124-144i156-180o200-220i241-264o284-308i335-354o360-380i401-423o429-449iCytoplasmicMembrane10
YIDC_ECOLIP25714
yidC
b3705 JW3683 integral IM protein (SEC in IM), insertase YidCIntegral Inner Membrane YidC, the Escherichia coli homologue of mitochondrial Oxa1p, is a component of the Sec translocase. The first periplasmic region of YidC include residues 24???346. Residues 215???265 of YidC are sufficient for SecF binding. The interaction of YidC with SecF is though not critical for cell viability as YidC, lacking residues 24-264, was fully functional to support the growth of <i>E. coli</i>. The integration of YidC into the cytoplasmic membrane requires the signal recognition particle, SecA and SecYEG.PMID: 10675323 PMID: 17073462 PMID: 11777926 PMID: 11821429 PMID: 16079137 PMID: 15919657Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRP (exp)SECyesyesN250.321SpI2412.0898-44Yn7-17c24/25o354-373i417-440o464-482i494-519oCytoplasmicMembrane1026
LYSP_ECOLIP25737
lysP

cadR

cadRb2156 JW2143 integral IM protein (SEC in IM), Lysine-specific permease LysPIntegral Inner Membrane Lysine-specific permease LysP and the membrane-integrated pH sensor CadC induce lysine-dependent adaptation of E. coli under acidic stress. In absence of lysine or high low pH LysP and CadC form stable complex. Probably CadC is inhibited by LysP via intramembrane and periplasmic contacts under non-inducing conditions. The membrane-integrated transcriptional activator CadC of Escherichia coli senses lysine indirectly via the interaction with the lysine permease LysP.PMID: 15919996 PMID: 24056175 PMID: 18086202Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN470.175TMH010.7386-1212Ni21-43o49-66i103-125o131-149i161-182o202-224i245-267o287-312i348-365o371-394i415-435o447-467iCytoplasmicMembrane10
YCHE_ECOLIP25743
ychE
b1242 JW1229 integral IM protein (SEC in IM), UPF0056 YchEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN420.169TMH010.9574-66No12-32i52-72o78-97i118-141o147-168i189-210oCytoplasmicMembrane1013
MDTG_ECOLIP25744
mdtG

yceE

yceEb1053 JW1040 integral IM protein (SEC in IM), Multidrug resistance MdtGIntegral Inner Membrane PMID: 11566977Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane Protein(experimental)SRPSECnoyesN320.145TMH016.0858-1010Ni16-40o52-74i86-104o110-130i142-162o174-193i220-245o257-278i290-308o374-393iCytoplasmicMembrane10
YEIB_ECOLIP25747
yeiB
b2152 JW2139 integral IM protein (SEC in IM), YeiBIntegral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN320.167TMH09.38597-1010Ni9-28o48-71i83-101o107-122i134-153o201-221i233-254o274-292i312-332o338-359iCytoplasmicMembrane10
FLIF_ECOLIP25798
fliF

fla AII.1 fla BI

fla AII.1 fla BIb1938 JW1922 Flagellar integral IM protein (SEC in IM), M-ring protein FliFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinflagellumSRPSECnoyesN460.141SpI433.78777-22Ni23-43o451-468iCytoplasmicMembrane1054
LEP4_ECOLIP25960
gspO

hofD hopD hopO yheC

hofD hopD hopO yheCb3335 JW3297 integral IM protein (SEC in IM), Type 4 prepilin-like proteins leader peptide-processing enzyme GspOIntegral Inner Membrane Part of gsp locus. PMID: 15919996PMID: 11118204 PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN240.153TMH00.982152-75Yn4-15c21/22o55-84i104-122o128-149i161-191o203-222iCytoplasmicMembrane10
FEPE_ECOLIP26266
fepE
b0587 JW0579 integral IM protein (SEC in IM), Ferric enterobactin transport FepE Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN460.11CYT0-0.200913-22Ni42-61o339-362iCytoplasmicMembrane1033
APPB_ECOLIP26458
appB

cbdB cyxB

cbdB cyxBb0979 JW0961 integral IM protein (SEC in IM), Cytochrome bd-II ubiquinol oxidase subunit 2 AppBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN410.107TMH010.1949-89No12-40i61-79o85-103i123-148o168-188i209-233o263-283i290-314o334-356iCytoplasmicMembrane10
APPC_ECOLIP26459
appC

cbdA cyxA

cbdA cyxAb0978 JW0960 integral IM protein (SEC-YidC in IM), Cytochrome bd-II ubiquinol oxidase subunit 1 AppCIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN370.11TMH011.9815-99No20-42i54-71o91-116i128-145o184-208i215-235o386-409i421-442o471-492iCytoplasmicMembrane10
PLSC_ECOLIP26647
plsC

parF

parFb3018 JW2986 integral IM protein (SEC in IM), 1-acyl-sn-glycerol-3-phosphate acyltransferase PlsCIntegral Inner Membrane PMID: 1557036Integral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane Membrane anchored (Experimental)SECyesyesN360.111TMH01.55803-11No6-27iCytoplasmicMembrane1028
RHAT_ECOLIP27125
rhaT
b3907 JW3878 integral IM protein (SEC in IM), L-rhamnose-proton symporter RhaTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted) , Soluble IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN200.227TMH012.7916-1010No6-26i38-58o64-85i97-121o133-154i175-194o214-234i255-277o289-310i322-343oCytoplasmicMembrane10
RFAL_ECOLIP27243
rfaL

waaL

waaLb3622 JW3597 integral IM protein (SEC in IM), O-antigen ligase RfaLIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN370.114TMH00.404949-1212Ni20-38o44-60i72-91o103-122i134-152o172-189i196-212o218-233i240-258o349-368i375-393o399-415iCytoplasmicMembrane10
LPXK_ECOLIP27300
lpxK

ycaH

ycaHb0915 JW0898 integral IM protein (SEC in IM), Tetraacyldisaccharide 4'-kinase LpxKIntegral Inner MembraneBBinout/inIM (predicted)Integral Membrane ProteinSRPSECnoyesN440.107TMH01.00613-11No12-34iUnknown230
EMRA_ECOLIP27303
emrA
b2685 JW2660 integral IM protein (SEC in IM), Multidrug export EmrA Integral Inner Membrane PMID: 1409590 PMID: 12482849Integral Inner MembraneBBoutin/outSoluble IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN380.157TMH06.79297-11Ni23-44oCytoplasmicMembrane1025
RODZ_ECOLIP27434
rodZ

yfgA

yfgAb2516 JW2500 nucleoid & integral IM protein (SEC in IM), Cytoskeleton RodZIntegral Inner Membrane, NucleoidSignal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. Quantitative immunoblotting agaist RodZ purified protein indicate that RodZ is present at ~650 copies per average exponentially growing cell in LB medium and M9. The hth domain of RodZ is not required for transcription but for interaction with MreB. The protein, RodZ, is required for assembly of the actin cytoskeleton MreB that controls cell wall synthesis and cell shape. PMID: 19194484PMID: 23138451 PMID: 9008159 PMID: 19078962 PMID: 21890895 PMID: 19008860 PMID: 15919657 PMCID: PMC2637328 PMID: 19194484Integral Inner Membrane, NucleoidB, NIM (predicted)Cell inner membrane Membrane anchoredSECyesyesN350.243CYT0-0.200913-11Ni112-133oUnknown2
WZYE_ECOLIP27835
wzyE

wzy

wzyb3793 JW3769 integral IM protein (SEC in IM), Probable ECA polymerase WzyEIntegral Inner Membrane PMID: 16816184Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN220.116TMH014.4283-1111No6-26i38-58o70-88i115-137o157-175i182-199o205-220i227-245o337-361i381-398o410-430iCytoplasmicMembrane10
YIFK_ECOLIP27837
yifK
b3795 JW5595 integral IM protein (SEC in IM), Probable transport YifK Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN420.143TMH08.10925-1212Ni12-34o40-60i94-119o125-146i158-177o197-219i240-259o271-299i333-353o359-380i401-423o429-448iCytoplasmicMembrane1031
RARD_ECOLIP27844
rarD
b3819 JW5589 integral IM protein (SEC in IM), RarDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.239TMH09.7991-1010Ni12-31o43-61i73-92o104-121i128-145o151-167i179-198o210-230i242-261o273-290iCytoplasmicMembrane10
NARQ_ECOLIP27896
narQ
b2469 JW2453 integral IM protein (SEC in IM), Nitrate/nitrite sensor NarQ Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN410.145TMH01.10259-22No14-34i147-169oCytoplasmicMembrane107
BCR_ECOLIP28246
bcr

bicA bicR sur suxA

bicA bicR sur suxAb2182 JW5363 integral IM protein (SEC-YidC in IM), Bicyclomycin resistance BcrIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN330.128TMH013.9575-1212Ni7-26o46-65i77-96o102-123i135-159o165-185i215-241o253-273i285-307o313-332i344-366o372-391iCytoplasmicMembrane10
ASMA_ECOLIP28249
asmA

yegA

yegAb2064 JW2049 integral IM protein (SEC in IM), AsmAIntegral Inner Membrane Involved in outer memebrane protein assembly and has an apparent signal peptide. It has been predicted to be periplasmic or outer membrane protein but detailed sub-fractionation studies revealed that it is localized to the inner membranePMID: 8866482. Reduced LPS levels in asmA mutants indicate a possible role of AsmA in LPS biogenesis.PMID: 8866482 PMID: 19346309 PMID: 7476172 PMCID: PMC178309Integral Inner MembraneBBoutin/outN/APeriplasm Membrane anchoredSRPSECyesyesN260.141TMH010.2137-10Yn4-16c21/22oUnknown269
DINF_ECOLIP28303
dinF
b4044 JW4004 integral IM protein (SEC in IM), DNA damage-inducible F DinFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN210.258TMH03.41253-1313No6-22i29-49o61-83i103-124o152-173i180-199o205-227i259-278o284-302i338-359o371-393i405-422o428-446iCytoplasmicMembrane1010
MLTG_ECOLIP28306
mltG

yceG

yceGb1097 JW1083 integral IM protein (SEC in IM), Endolytic murein transglycosylase MltGIntegral Inner MembraneBBoutin/outN/ACell inner membrane Membrane anchoredSRPSECyesyesN200.198SpI180.538854-10Yn4-15c20/21oUnknown616
CYDD_ECOLIP29018
cydD

htrD

htrDb0887 JW0870 integral IM protein (SEC-YidC in IM), ATP-binding/permease CydDIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919657 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN430.111TMH00.800558-56Ni29-49o61-82i140-159o165-188i245-272o278-297iCytoplasmicMembrane10
FTSN_ECOLIP29131
ftsN

msgA

msgAb3933 JW3904 integral IM protein (SEC in IM), Cell division FtsNIntegral Inner Membrane Localizes to potential division sites in filamentous cells. FtsN interacts directly with itself, FtsW, FtsI and ZapA.PMID: 11703663 PMID: 20497333Integral Inner MembraneBBoutin/outSoluble IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN410.126SpI400.332384-11Ni29-54oCytoplasmicMembrane1023
THIF_ECOLIP30138
thiF
b3992 JW3956 integral IM protein (SEC in IM), Sulfur carrier ThiS adenylyltransferase ThiFIntegral Inner Membrane Very strong TMHMM and Phobius and Kyte/Doolittle predictions for at least one TM region. Proteins that have activities as nucleoside-triphosphatase and hydrolysis of thiamin triphosphate in Escherichia coli have been shown to be membrane-bound but there is no experimental evidence for ThiF PMID: 3026493.PMID: 3026493Integral Inner MembraneBBoutin/outN/AMembrane anchoredSRPSECyesyesN590.161CYT0-0.200913-10NiCytoplasmic945
YAAJ_ECOLIP30143
yaaJ
b0007 JW0006 integral IM protein (SEC in IM), transporter YaaJIntegral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN300.113TMH010.2038-99No12-30i68-87o93-116i137-156o176-194i206-228o297-321i342-370o414-438iCytoplasmicMembrane10
YABI_ECOLIP30149
yabI
b0065 JW5005 integral IM protein (SEC in IM) of DedA family, YabIIntegral Inner Membrane Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF. PMID: 15919996PMID: 15919996 PMID: 23086209Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN430.146TMH011.6076-55Ni12-36o56-79i145-165o177-196i217-236oCytoplasmicMembrane1017
BASS_ECOLIP30844
basS

pmrB

pmrBb4112 JW4073 integral IM protein (SEC-YidC in IM), Sensor BasSIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN350.113TMH03.38744-22Ni14-34o65-85iCytoplasmicMembrane1020
EPTA_ECOLIP30845
eptA

pmrC yjdB

pmrC yjdBb4114 JW5730 integral IM protein (SEC in IM), Phosphoethanolamine transferase EptA Integral Inner Membrane YjdB co-localizes with the ZipA protein and is involved in cell division. Has been purified as a complex with ZipA-EptA.PMID: 16079137Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN210.157TMH013.2858-55Ni12-33o45-66i78-100o120-142i154-176oCytoplasmicMembrane10
BAES_ECOLIP30847
baeS
b2078 JW2063 integral IM protein (SEC-YidC in IM), Signal transduction histidine-kinase BaeSIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN310.161TMH06.32525-22Ni12-31o168-186iCytoplasmicMembrane1031
EVGS_ECOLIP30855
evgS
b2370 JW2367 integral IM protein (SEC in IM), Sensor EvgSIntegral Inner Membrane Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 25403562Integral Inner MembraneBBoutout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECYfgMnoyesY220.874SpI217.57923-01Yn3-14c21/22o536-558iCytoplasmicMembrane9
YEDE_ECOLIP31064
yedE
b1929 JW1914 integral IM protein (SEC in IM), UPF0394 YedEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN240.167TMH016.7358-1010Ni12-32o81-100i112-136o148-171i197-215o221-240i260-280o292-314i321-341o361-382iCytoplasmicMembrane10
KCH_ECOLIP31069
kch
b1250 JW1242 integral IM protein (SEC in IM), Voltage-gated potassium channel Kch Integral Inner Membrane PMID: 8824224 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN270.106TMH02.91162-76Ni21-39o59-80i87-104o110-127i139-161o200-225iCytoplasmicMembrane10
AAS_ECOLIP31119
aas
b2836 JW2804 integral IM protein (SEC-YidC in IM), Bifunctional Aas AasIntegral Inner Membrane Integral membrane protein (experimental; from GenProtEC) Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384Integral Inner MembraneBBpolyout/outSoluble IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN570.217CYT0-0.200913-02No258-277i415-438oCytoplasmicMembrane107
SOTB_ECOLIP31122
sotB

ydeA

ydeAb1528 JW1521 integral IM protein (SEC in IM), Sugar efflux transporter SotBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN220.15TMH012.9623-1212Ni12-36o48-68i80-99o105-126i138-156o168-189i210-232o244-265i272-293o299-321i333-352o364-384iCytoplasmicMembrane10
EAMA_ECOLIP31125
eamA

ydeD

ydeDb1533 JW5250 integral IM protein (SEC-YidC in IM), Probable amino-acid metabolite efflux pump EamAIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN370.113TMH010.8414-1010Ni7-27o33-52i61-82o88-108i117-135o141-161i173-196o216-237i244-263o269-289iCytoplasmicMembrane104
YDEE_ECOLIP31126
ydeE

ydeF

ydeFb1534 JW1527 integral IM protein (SEC in IM), MFS-type transporter YdeE Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN260.123TMH010.3798-1211Yn8-19c24/25o44-63i75-93o99-121i133-156o162-182i207-233o245-263i275-293o299-323i335-357o363-381iCytoplasmicMembrane1094
POTH_ECOLIP31135
potH
b0856 JW0840 integral IM protein (SEC in IM), Putrescine transport system permease PotH Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN580.132CYT0-0.200913-66Ni31-52o103-122i134-155o185-208i229-253o284-305iCytoplasmicMembrane10
ACRB_ECOLIP31224
acrB

acrE

acrEb0462 JW0451 integral IM protein (SEC-YidC in IM), Multidrug efflux pump subunit AcrB Integral Inner Membrane AcrB is a major multidrug exporter in Escherichia coli. It cooperates with a membrane fusion protein, AcrA, and an outer membrane channel, TolC (AcrAB-TolC multidrug efflux system) PMID: 15228545. Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertionPMID: 9008159. Exhibites aberrant localization by microscopy in the absence of YidCPMID: 22108384. Crystal structure of AcrB shows three AcrB protomers are organized as a homotrimer in the shape of a jellyfish. In the transmembrane region, each protomer has twelve transmembrane alpha-helicesPMID: 12374972.PMID: 9008159 PMID: 11266632 PMID: 12374972 PMID: 22108384 PMID: 15228545 PMID: 16079137 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRP (exp)SEC-YidCyesyesN550.156TMH04.86972-1112Ni12-32o340-359i366-390o396-416i437-458o470-493i541-557o875-892i899-919o925-946i975-995o1007-1029iCytoplasmicMembrane10
YICH_ECOLIP31433
yicH
b3655 JW3630 integral IM protein (SEC in IM), YicHIntegral Inner MembraneBBoutin/outSoluble IM FractionMembrane anchoredSRPSECyesyesN330.134TMH07.0277-11Ni7-26oUnknown27
YICJ_ECOLIP31435
yicJ
b3657 JW5939 integral IM protein (SEC in IM), symporter YicJIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN570.115TMH02.46347-1112Ni12-34o40-58i79-98o110-132i152-174o180-202i232-258o264-283i295-313o319-342i363-390o402-424iCytoplasmicMembrane10
SETC_ECOLIP31436
setC

yicK

yicKb3659 JW3633 integral IM protein (SEC in IM), Sugar efflux transporter C SetCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN320.244TMH09.2462-1211Yn14-25c33/34o49-70i82-100o106-129i141-161o173-193i221-238o258-277i284-308o314-331i352-368o374-391iCytoplasmicMembrane10
YICL_ECOLIP31437
yicL
b3660 JW3634 integral IM protein (SEC in IM), transporter YicLIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.389TMH07.96611-109Yn11-18c25/26o41-60i72-94o100-120i127-146o152-172i184-205o217-237i249-270o276-293iCytoplasmicMembrane10
ADEQ_ECOLIP31440
adeQ

yicO

yicOb3664 JW5636 integral IM protein (SEC in IM), Adenine permease AdeQIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN570.125CYT0-0.200913-1312No33-51i63-86o98-131i143-161o181-199i206-227o247-267i296-318o330-350i357-377o389-413i425-443oCytoplasmicMembrane10
EMRD_ECOLIP31442
emrD

yicQ

yicQb3673 JW5634 integral IM protein (SEC-YidC in IM), Multidrug resistance D EmrDIntegral Inner Membrane EmrD is a multidrug transporter from the Major Facilitator Superfamily that expels amphipathic compounds across the inner membrane of Escherichia coli. Crystal structure of EmrD reveals an interior that is composed mostly of hydrophobic residues, which is consistent with its role transporting amphipathic molecules. Two long loops extend into the inner leaflet side of the cell membrane.PMID: 16675700. Exhibites aberrant localization by microscopy in the absence of YidCPMID: 22108384.PMID: 11266632 PMID: 16675700 PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCyesyesN240.319SpI239.69754-1211Yn9-20c25/26o44-63i75-92o98-116i136-159o165-183i203-226o232-261i273-291o297-318i330-353o365-383iCytoplasmicMembrane10
YIDK_ECOLIP31448
yidK
b3679 JW3655 integral IM protein (SEC in IM), symporter YidKIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN230.12CYT0-0.200913-1515No6-22i34-56o76-98i119-141o161-180i192-212o242-261i282-307o327-349i381-397o409-427i434-454o460-481i506-526o532-550iCytoplasmicMembrane10
PTXC_ECOLIP31452
glvC
b3683 JW3660 integral IM protein (SEC in IM), Phosphotransferase IIC component GlvC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoN510.159TMH011.5504-910Ni12-32o63-80i87-109o129-153i174-194o206-222i234-255o275-298i305-323o329-356iCytoplasmicMembrane10
MDTL_ECOLIP31462
mdtL

yidY

yidYb3710 JW3688 integral IM protein (SEC in IM), Multidrug resistance MdtLIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.157TMH02.89051-1111Yn4-12c16/17o40-58i70-89o95-116i128-152o158-178i199-222o242-262i269-287o293-312i324-345o351-376iCytoplasmicMembrane10
ADEP_ECOLIP31466
adeP

purP yieG

purP yieGb3714 JW3692 integral IM protein (SEC in IM), Adenine permease AdePIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN120.099TMH00.786304-1313Ni32-56o62-81i88-106o112-130i142-161o181-199i206-226o246-266i295-317o329-349i356-376o388-412i424-442oCytoplasmicMembrane10
HSRA_ECOLIP31474
hsrA

yieO

yieOb3754 JW3733 integral IM protein (SEC in IM), Probable transport HsrA Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN390.237TMH08.54455-1413Yn10-21c27/28o51-71i78-97o103-124i136-158o164-182i194-211o223-244i264-287o293-314i326-347o353-374i394-417o429-450iCytoplasmicMembrane10
METI_ECOLIP31547
metI

yaeE

yaeEb0198 JW0194 integral IM protein (SEC in IM), D-methionine transport system permease MetIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.111TMH018.923-55No20-40i52-76o82-105i142-162o182-203iCytoplasmicMembrane10
THIP_ECOLIP31549
thiP

yabK

yabKb0067 JW0066 integral IM protein (SEC in IM), Thiamine transport system permease ThiP Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN300.209TMH018.9215-1212Ni12-38o58-78i90-114o134-151i199-220o240-260i289-311o331-354i375-394o406-424i465-484o504-525iCytoplasmicMembrane1011
CAIT_ECOLIP31553
caiT

yaaP

yaaPb0040 JW0039 integral IM protein (SEC-YidC in IM), L-carnitine/gamma-butyrobetaine antiporter CaiTIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN360.144TMH016.018-1212Ni12-30o50-71i91-116o145-163i195-216o228-251i263-286o318-335i347-366o406-425i446-466o472-495iCytoplasmicMembrane10
SETA_ECOLIP31675
setA

yabM

yabMb0070 JW0069 integral IM protein (SEC in IM), Sugar efflux transporter A SetAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN470.202TMH015.307-1211Yn13-24c32/33o48-70i82-99o105-127i148-166o172-196i217-236o256-275i282-301o307-329i341-363o369-387iCytoplasmicMembrane10
YAAU_ECOLIP31679
yaaU

yabE

yabEb0045 JW0044 integral IM protein (SEC in IM), Putative metabolite transport YaaU Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN300.102TMH07.08001-1212Ni20-42o54-74i86-104o110-132i144-166o172-193i242-263o283-303i310-329o335-358i370-390o402-421iCytoplasmicMembrane10
DJLA_ECOLIP31680
djlA

yabH

yabHb0055 JW0054 integral IM protein (SEC in IM), Co-chaperone DjlAIntegral Inner Membrane PMID: 11106641Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN220.135TMH010.4559-11No6-30iCytoplasmicMembrane1011
CHAA_ECOLIP31801
chaA
b1216 JW1207 integral IM protein (SEC in IM), Sodium-potassium/proton antiporter ChaA Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN620.229TMH01.59472-1111Ni15-32o38-60i72-94o106-131i143-164o170-188i221-240o252-269i290-313o319-340i347-365oCytoplasmicMembrane10
YDDA_ECOLIP31826
yddA
b1496 JW5242 integral IM protein (SEC in IM), ABC transporter ATP-binding YddAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN260.12CYT0-0.200913-55No6-24i31-51o71-90i152-173o193-210iCytoplasmicMembrane10
YIHF_ECOLIP32128
yihF
b3861 JW5574 integral IM protein (SEC in IM), YihFIntegral Inner Membrane Potential Signal Peptide. It appears to have aminotemrinal TM. It is homologous to YDGA_ECOLI. Integral Inner MembraneBBoutin/outN/AMembrane anchoredSRPSECnoyesN250.128SpI232.38596-10Yn5-13c18/19oCytoplasmicMembrane982
YIHG_ECOLIP32129
yihG
b3862 JW3834 integral IM protein (SEC in IM), Probable acyltransferase YihG Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inN/ACell inner membrane; Multi-pass membrane proteinCytoplasmicSRPSECnoyesN410.134TMH09.85797-13No14-47i59-77o97-116iCytoplasmicMembrane1015
YIHN_ECOLIP32135
yihN
b3874 JW3845 integral IM protein (SEC in IM), YihNIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Membrane LipoproteinSRPSECnoyesN230.116SpII155.95413Pos+2=G1211Yn7-17c22/23o46-67i74-90o96-122i143-165o171-189i221-242o248-268i289-308o314-339i351-374o386-406iCytoplasmicMembrane10
YIHO_ECOLIP32136
yihO
b3876 JW5852 integral IM protein (SEC in IM), Putative sulfoquinovose importer YihOIntegral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN210.104TMH05.69819-1112Ni17-38o50-74i86-106o118-139i160-179o185-206i238-258o270-291i303-322o328-350i381-402o414-436iCytoplasmicMembrane10
YIHP_ECOLIP32137
yihP
b3877 JW3848 integral IM protein (SEC in IM), Putative 2,3-dihydroxypropane-1-sulfonate exporter YihPIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN680.101CYT0-0.200913-1111Ni20-41o53-77i89-109o121-143i164-183o189-210i244-264o276-297i309-328o334-356i421-442oCytoplasmicMembrane10
PTFLB_ECOLIP32154
frvB

yiiJ

yiiJb3899 JW5562 integral IM protein (SEC in IM), Fructose-like PTS system EIIBC component FrvBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN210.166CYT0-0.200913-910Ni139-159o179-198i205-222o228-247i259-281o301-321i342-363o375-396i403-422o442-463iCytoplasmicMembrane10
MENA_ECOLIP32166
menA

yiiW

yiiWb3930 JW3901 integral IM protein (SEC in IM), 1,4-dihydroxy-2-naphthoate octaprenyltransferase MenAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN360.309TMH04.61773-99Ni21-38o44-63i98-118o124-143i150-172o178-199i228-246o252-270i290-307oCytoplasmicMembrane1014
PTFC2_ECOLIP32672
frwC

yijJ

yijJb3949 JW3921 integral IM protein (SEC in IM), Fructose-like permease IIC component 2 FrwCIntegral Inner Membrane Multiphosphoryl transfer protein 2PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN510.192TMH04.57594-89No22-45i57-78o98-120i132-152o172-190i202-229o249-269i281-301o313-334iCytoplasmicMembrane10
PDEC_ECOLIP32701
pdeC

yjcC

yjcCb4061 JW4022 integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN350.165TMH03.89399-22Ni12-34o243-264iCytoplasmicMembrane10
YJCE_ECOLIP32703
yjcE
b4065 JW4026 integral IM protein (SEC in IM), YjcEIntegral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN690.131TMH07.97851-1113No6-25i32-50o56-73i85-108o114-136i157-179o185-204i216-235o241-259i280-298o313-337i361-385o397-420iCytoplasmicMembrane10
ACTP_ECOLIP32705
actP

yjcG

yjcGb4067 JW4028 integral IM protein (SEC in IM), Cation/acetate symporter ActPIntegral Inner Membrane PMID: 16079137 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesY190.597SpI1816.2988-1313Yn4-14c18/19o34-54i75-97o103-122i148-167o179-197i209-227o262-286i298-323o355-383i404-423o429-453i465-486o498-517iCytoplasmicMembrane10
NRFD_ECOLIP32709
nrfD

yjcK

yjcKb4073 JW4034 integral IM protein (SEC in IM), NrfDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN460.148TMH010.9164-88No18-39i51-73o93-113i150-168o180-203i224-241o261-278i290-312oCytoplasmicMembrane10
NRFE_ECOLIP32710
nrfE

yjcL

yjcLb4074 JW4035 integral IM protein (SEC in IM), Probable cytochrome c-type biogenesis NrfE Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN100.193TMH07.53708-1212Ni21-54o79-97i104-126o158-178i190-212o232-248i260-288o294-312i333-357o377-394i401-422o528-545iCytoplasmicMembrane10
MDTO_ECOLIP32715
mdtO

yjcQ

yjcQb4081 JW4042 integral IM protein (SEC in IM), Multidrug resistance MdtOIntegral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN190.102CYT0-0.200913-99No36-63i75-97o103-120i127-146o152-178i399-420o426-445i457-477o483-502iCytoplasmicMembrane10
MDTN_ECOLIP32716
mdtN

yjcR

yjcRb4082 JW4043 integral IM protein (SEC in IM), Multidrug resistance MdtNIntegral Inner MembraneBBoutin/outN/ACell inner membrane Membrane anchoredSRPSECnoyesN470.139SpI357.86193-10Yn15-30c35/36oCytoplasmicMembrane9
ALSC_ECOLIP32720
alsC

yjcV

yjcVb4086 JW4047 integral IM protein (SEC-YidC in IM), D-allose transport system permease AlsCIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSEC-YidCnoyesN490.11TMH04.98579-98Ni21-42o71-93i105-129o168-193i222-246o252-272i279-298o304-324iCytoplasmicMembrane10
YEEA_ECOLIP33011
yeeA
b2008 JW1990 integral IM protein (SEC in IM), YeeAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN300.114TMH06.9225-56Ni20-40o46-66i73-89o95-113i120-136o148-168iCytoplasmicMembrane1032
YEEE_ECOLIP33015
yeeE
b2013 JW1995 integral IM protein (SEC in IM), UPF0394 YeeEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN590.121TMH04.74224-99Yn6-17c25/26o41-60i72-100o106-123i144-169o198-217i224-241o247-266i287-310o316-337iCytoplasmicMembrane10
NUPX_ECOLIP33021
nupX

yeiJ

yeiJb2161 JW2148 integral IM protein (SEC in IM), Putative nucleoside permease NupX Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane Protein(experimental)SRPSECyesyesN570.114TMH03.09344-810No6-22i29-49o61-82i89-108o114-132i173-195o201-220i258-280o353-380i392-415oCytoplasmicMembrane10
PSUT_ECOLIP33024
psuT

pscT yeiM

pscT yeiMb2164 JW2151 integral IM protein (SEC in IM), Putative pseudouridine transporter PsuTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN250.143TMH02.44494-810No6-22i29-49o95-118i173-195o201-220i258-280o286-310i322-341o353-378i390-413oCytoplasmicMembrane10
SETB_ECOLIP33026
setB

yeiO

yeiOb2170 JW2157 integral IM protein (SEC in IM), Sugar efflux transporter B SetBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN330.175TMH08.14886-1212Ni12-33o53-72i84-101o107-129i141-158o164-194i219-244o256-276i283-301o307-330i351-367o373-390iCytoplasmicMembrane10
FLIR_ECOLIP33135
fliR

flaP

flaPb1950 JW1934 Flagellar integral IM protein (SEC in IM), biosynthetic FliRIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinflagellumSRPSECnoyesN610.121TMH05.44162-66No15-33i42-59o65-86i131-151o179-201i213-237oCytoplasmicMembrane10
YEBE_ECOLIP33218
yebE
b1846 JW1835 integral IM protein (SEC in IM), YebEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inN/ACell inner membrane; Single-pass membrane proteinMembrane anchoredSRPSECnoyesN240.329SpI230.790424-22No26-44i56-74oCytoplasmicMembrane1088
TORC_ECOLIP33226
torC
b0996 JW0981 integral IM protein (SEC in IM), Cytochrome c-type TorCIntegral Inner Membrane TAT secretion system. Binds 5 heme groups per subunit ; Belongs to the torC/torY family. Trimethylamine N-oxide (TMAO) respiration system is encoded by the torCAD operon and comprises a periplasmic TMAO reductase (TorA) and a c-type cytochrome (TorC), which shuttles electrons to TorA. The immature C-terminal domain of TorC strongly down-regulated the tor operon and interacted with the TorS detector region. Electron transfer and binding of the c-type cytochrome TorC to the trimethylamine N-oxide reductase PMID: 11056172PMID: 17218314 PMID: 11562502 PMID: 11056172Integral Inner MembraneBBoutin/outN/ACell inner membrane; Single-pass type II membrane proteinPeriplasmic with N-terminal membrane anchor (Experimental)SRPSECyesyesN200.12TMH06.50112-11Ni12-34oCytoplasmicMembrane943
LLDP_ECOLIP33231
lldP

lctP

lctPb3603 JW3578 integral IM protein (SEC in IM), L-lactate permease LldPIntegral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion.PMID: 9008159 PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRP (exp)SECyesyesN660.171TMH011.5559-1212No12-33i40-58o70-95i116-149o155-179i199-217o223-240i252-269o368-387i407-425o431-456i529-550oCytoplasmicMembrane10
YEHW_ECOLIP33359
yehW
b2128 JW2116 integral IM protein (SEC in IM), Glycine betaine uptake system permease YehW Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN310.403TMH015.5124-65Yn8-22c30/31o46-74i86-111o117-144i164-189o201-226iCytoplasmicMembrane1015
YEHY_ECOLIP33361
yehY
b2130 JW2118 integral IM protein (SEC in IM), Glycine betaine uptake system permease YehY Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN300.257TMH013.4216-109Yn9-16c20/21o44-65i72-90o102-123i135-153o183-204i225-246o258-278i324-347o353-379iCytoplasmicMembrane10
YOHD_ECOLIP33366
yohD
b2136 JW2124 integral IM protein (SEC in IM) of DedA family, YohDIntegral Inner Membrane Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF.PMID: 15919996 PMID: 23086209Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN220.131CYT0-0.200913-44Ni12-35o41-63i122-143o163-180iCytoplasmicMembrane1065
NIKB_ECOLIP33591
nikB
b3477 JW3442 integral IM protein (SEC in IM), Nickel transport system permease NikB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.197TMH011.5427-66Ni9-29o104-125i137-164o176-195i232-255o275-298iCytoplasmicMembrane10
NUOL_ECOLIP33607
nuoL
b2278 JW2273 integral IM protein (SEC in IM), NADH-quinone oxidoreductase subunit L NuoLIntegral Inner Membrane PMID: 20732298 PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN270.186TMH09.92034-1617Yn4-15c19/20o29-52i64-81o87-104i116-133o139-158i170-189o209-228i249-267o279-300i307-325o331-354i374-392o412-434i455-475o495-513i534-560o593-612iCytoplasmicMembrane10
FEOB_ECOLIP33650
feoB
b3409 JW3372 integral IM protein (SEC in IM), FeoBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN200.107CYT0-0.200913-109No282-302i309-327o347-367i421-447o453-473i511-529o664-685i697-715o721-742iCytoplasmicMembrane108
YEJE_ECOLIP33915
yejE
b2179 JW2167 integral IM protein (SEC in IM), ABC transporter permease YejEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN430.206TMH06.40686-66Ni21-42o142-167i179-197o203-222i259-286o306-327iCytoplasmicMembrane10
CCMF_ECOLIP33927
ccmF

yejR

yejRb2196 JW2184 integral IM protein (SEC in IM), Cytochrome c-type biogenesis CcmFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN540.151TMH012.9934-1515No6-29i41-62o96-114i121-142o178-198i210-230o250-267i274-294o314-332i353-374o394-412i424-444o450-472i484-503o609-629iCytoplasmicMembrane10
NAPH_ECOLIP33934
napH

yejZ

yejZb2204 JW2192 integral IM protein (SEC in IM), Ferredoxin-type NapHIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN470.13TMH07.44595-44Ni30-50o78-98i139-160o172-192iCytoplasmicMembrane106
YOJI_ECOLIP33941
yojI

yojJ

yojJb2211 JW2199 integral IM protein (SEC in IM), ABC transporter ATP-binding/permease YojIIntegral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN300.136TMH012.5457-66Ni12-36o56-80i125-144o150-169i231-253o273-296iCytoplasmicMembrane1018
MDTD_ECOLIP36554
mdtD

yegB

yegBb2077 JW2062 integral IM protein (SEC in IM), Putative multidrug resistance MdtD Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN380.206TMH07.65965-1313Ni12-33o45-64i76-96o102-123i135-157o163-185i197-214o226-243i263-280o286-308i329-355o396-418i430-451oCytoplasmicMembrane10
COBS_ECOLIP36561
cobS
b1992 JW1970 integral IM protein (SEC in IM), Adenosylcobinamide-GDP ribazoletransferase CobSIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN580.15TMH03.98364-46Ni34-58o64-88i109-132o138-158i178-196o202-219iCytoplasmicMembrane102
HOFC_ECOLIP36646
hofC

hopC yacD

hopC yacDb0106 JW0102 integral IM protein (SEC in IM), transport homolog HofCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN190.132CYT0-0.200913-34Ni162-185o216-234i263-281o369-389iCytoplasmicMembrane10
DSBD_ECOLIP36655
dsbD

cutA2 cycZ dipZ

cutA2 cycZ dipZb4136 JW5734 integral IM protein (SEC in IM), Thiol:disulfide interchange DsbD Integral Inner Membrane DsbD is an inner membrane protein that is recognised and targeted to the Sec pathway by short, cleavable, N-terminal signal sequence. PMID: 15919996 Disulfide bridge (122 128;182 304;480 483) PMID: 18406599 PMID: 7628442 PMID: 15919996 Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesY200.853SpI1910.1575-87Yn5-13c19/20o168-195i207-231o243-267i288-317o329-351i363-381o387-406iCytoplasmicMembrane10
PTTBC_ECOLIP36672
treB
b4240 JW4199 integral IM protein (SEC in IM), PTS system trehalose-specific EIIBC component TreBIntegral Inner Membrane Trigger factor-sensitive aggregation.PMID: 19737520 PMID: 15919657 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRP,TFSECnoyesN440.348CYT0-0.200913-1010Ni107-131o159-180i187-208o228-245i257-281o301-321i341-361o373-392i399-418o438-461iCytoplasmicMembrane104
GSPM_ECOLIP36678
gspM

hopZ pshM

hopZ pshMb3334 JW5704 integral IM protein (SEC in IM), Putative type II secretion system M GspMIntegral Inner Membrane Potential component of type II secretion system.PMID: 14966662 PMID: 11118204Integral Inner MembraneBBinout/inIM (predicted)Cell inner membrane Membrane anchoredSRPSECnoyesN300.121CYT0-0.200913-11No16-34iUnknown2
DTPB_ECOLIP36837
dtpB

yhiP

yhiPb3496 JW3463 integral IM protein (SEC in IM), Dipeptide and tripeptide permease B DtpBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN610.154TMH06.34727-1414Ni28-46o52-72i84-101o107-124i145-167o173-193i214-232o238-256i268-285o320-337i349-371o383-408i415-437o457-479iCytoplasmicMembrane10
RSMB_ECOLIP36929
rsmB

fmu/fmv rrmB sun yhdB

fmu/fmv rrmB sun yhdBb3289 JW3250 integral IM protein (SEC in IM), Ribosomal RNA small subunit methyltransferase B RsmBIntegral Inner MembraneBBoutin/outIM (predicted)Cytoplasm CytoplasmicSRPSECyesyesN680.106CYT0-0.200913-01Ni76-93oCytoplasmic950
CRCB_ECOLIP37002
crcB

ybeI

ybeIb0624 JW0619 integral IM protein (SEC-YidC in IM), Putative fluoride ion transporter CrcB Integral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC. Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996PMID: 22108384 PMID: 15919996 PMID: 24688744 PMID: 16429150Integral Inner MembraneBBpolyin/out, out/inIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSEC-YidCyesyesN330.138TMH07.1142-43Yn2-10c15/16o31-55i67-91o97-121iCytoplasmicMembrane1019
CLCA_ECOLIP37019
clcA

eriC yadQ

eriC yadQb0155 JW5012 integral IM protein (SEC in IM), H(+)/Cl(-) exchange transporter ClcAIntegral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertionPMID: 9008159. Alpha-helcal transmembrane protein (experimental). The transmembrane segments are all helical and buried within the protein and the membranePMID: 11796999. C-terminal tagging with the alkaline phosphatase and green fluorescent protein in order to define the periplasmic or cytoplasmic locations of the C terminiPMID: 15919996.PMID: 9008159 PMID: 11266632 PMID: 11796999 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRP (exp)SECyesyesN500.115CYT0-0.200913-1110No33-53i74-97o177-201i213-232o252-270i291-308o328-348i355-376o388-413i420-439oCytoplasmicMembrane1038
RIR4_ECOLIP37146
nrdF

ygaD

ygaDb2676 JW2651 integral IM protein (SEC in IM), Ribonucleoside-diphosphate reductase 2 subunit beta NrdFIntegral Inner MembraneBBinoutin/outIM (predicted)CytoplasmicSRPSECyesyesN620.104CYT0-0.200913-01Ni152-172oUnknown231
FXSA_ECOLIP37147
fxsA

yjeG

yjeGb4140 JW4100 integral IM protein (SEC in IM), UPF0716 FxsAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN640.114TMH05.51241-33No6-24i29-47o78-101iCytoplasmicMembrane1025
HYBB_ECOLIP37180
hybB
b2995 JW5494 integral IM protein (SEC in IM), Probable Ni/Fe-hydrogenase 2 b-type cytochrome subunit HybBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN690.111TMH013.5768-1010Ni12-31o51-79i91-110o130-154i166-184o211-234i246-264o284-302i314-332o352-373iCytoplasmicMembrane10
YFDC_ECOLIP37327
yfdC
b2347 JW2344 integral IM protein (SEC in IM), YfdCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.112CYT0-0.200913-66Ni58-76o96-114i135-158o187-206i213-233o253-275iCytoplasmicMembrane1038
MDTK_ECOLIP37340
mdtK

norE norM ydhE

norE norM ydhEb1663 JW1655 integral IM protein (SEC in IM), Multidrug resistance MdtKIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN370.255TMH09.01951-1211Yn10-21c29/30o53-72i92-113o133-149i161-183o189-212i245-268o280-301i313-336o348-366i387-407o419-438iCytoplasmicMembrane10
YCAI_ECOLIP37443
ycaI
b0913 JW5120 integral IM protein (SEC in IM), YcaIIntegral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN410.135TMH010.6181-712No23-42i49-69o222-243i255-274o280-297i304-322o328-346i358-383o389-411i423-439o445-467i474-491oCytoplasmicMembrane10
YDHC_ECOLIP37597
ydhC
b1660 JW1652 integral IM protein (SEC in IM), transport YdhCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.384TMH010.7821-1211Yn7-22c30/31o40-61i73-91o97-119i131-155o161-180i209-229o235-258i270-293o299-322i334-355o361-381iCytoplasmicMembrane10
ZNTA_ECOLIP37617
zntA

yhhO

yhhOb3469 JW3434 integral IM protein (SEC in IM), Zinc/cadmium/lead-transporting P-type ATPase ZntAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN270.185CYT0-0.200913-58Ni128-144o150-168i180-197o203-222i353-374o380-404i686-702o708-729iCytoplasmicMembrane1026
QPTR_ECOLIP37619
yhhQ
b3471 JW3436 integral IM protein (SEC in IM), Queuosine precursor transporter YhhQIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN320.133TMH011.3075-66Ni12-31o43-64i71-92o104-127i139-165o185-206iCytoplasmicMembrane10
YHHS_ECOLIP37621
yhhS
b3473 JW5945 integral IM protein (SEC in IM), MFS-type transporter YhhS Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN470.135TMH08.30657-1212Ni19-41o47-65i85-103o109-131i152-175o181-199i220-241o253-271i283-303o309-330i342-364o370-388iCytoplasmicMembrane10
RBBA_ECOLIP37624
rbbA

yhiG yhiH

yhiG yhiHb3486 JW5676 integral IM protein (SEC in IM), Ribosome-associated ATPase RbbAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane CytoplasmicSRPSECyesyesN240.13CYT0-0.200913-56Ni558-579o716-739i766-789o795-817i824-845o884-906iCytoplasmicMembrane1017
YHII_ECOLIP37626
yhiI
b3487 JW3454 integral IM protein (SEC in IM), YhiIIntegral Inner MembraneBBoutin/outSoluble IM FractionMembrane anchoredSRPSECnoyesN310.132TMH04.13485-11Ni7-27oCytoplasmicMembrane7
YHIM_ECOLIP37630
yhiM
b3491 JW5944 integral IM protein (SEC in IM), YhiMIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN330.131TMH011.4226-1010Ni7-28o40-62i74-95o107-133i154-175o187-211i223-246o258-281i293-313o325-343iCytoplasmicMembrane10
YHIN_ECOLIP37631
yhiN
b3492 JW3459 integral IM protein (SEC in IM), YhiNIntegral Inner MembraneBBoutin/outN/ACytoplasmicSRPSECyesyesN230.367SpI223.94669-10Yn6-17c22/23oUnknown420
MDTF_ECOLIP37637
mdtF

yhiV

yhiVb3514 JW3482 integral IM protein (SEC in IM), Multidrug resistance MdtFIntegral Inner Membrane PMID: 16079137 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN550.14TMH07.6049-1112Ni12-32o340-359i366-390o396-416i437-458o470-497i539-555o873-890i897-917o923-948i969-989o1009-1031iCytoplasmicMembrane10
YHJD_ECOLIP37642
yhjD
b3522 JW3490 integral IM protein (SEC in IM), YhjDIntegral Inner MembranePMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN480.105CYT0-0.200913-65No72-97i186-209o229-250i262-282o294-321iCytoplasmicMembrane1013
YHJE_ECOLIP37643
yhjE
b3523 JW3491 integral IM protein (SEC in IM), metabolite transport YhjE Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN450.121CYT0-0.200913-1111No38-54i66-85o97-130i168-188o200-217i249-270o290-312i321-340o346-370i382-403o409-431iCytoplasmicMembrane10
YHJG_ECOLIP37645
yhjG

yhjF

yhjFb3524 JW3492 integral IM protein (SEC in IM), YhjGIntegral Inner MembraneBBoutin/outIM (predicted)Cell membrane Membrane anchoredSRPSECyesyesN330.12TMH01.70796-11Ni7-29oUnknown210
PDEK_ECOLIP37649
pdeK

yhjK

yhjKb3529 JW5943 integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeKIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN440.106TMH05.39989-22No12-35i151-176oCytoplasmicMembrane10
BCSB_ECOLIP37652
bcsB

yhjN

yhjNb3532 JW3500 integral IM protein (SEC-YidC in IM), Cyclic di-GMP-binding BcsBIntegral Inner Membrane BscC is involved in biosynthesis of cellulose, which is a significant constituent of the extracellular matrix. Encodes the catalytic subunit of cellulose synthase. Exhibites aberrant localization by microscopy in the absence of YidC. BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis. 24127606 Cellulose filaments have been visualized in situ via scanning electron and fluorescence microscopy. PMID: 24097954PMID: 2030672 PMID: 22108384 PMID: 15919996 24127606 PMID: 24097954Integral Inner MembraneBBoutout/inIM (predicted)Cell inner membrane; Single-pass type I membrane proteinIntegral Membrane ProteinSRPSEC-YidCnoyesY260.342SpI2520.4203-21Yn5-13c25/26o745-766iCytoplasmicMembrane1082
BCSA_ECOLIP37653
bcsA

yhjO yhjP

yhjO yhjPb3533 JW5665 integral IM protein (SEC in IM), Cellulose synthase catalytic subunit BcsAIntegral Inner Membrane BcsA and BcsB form the catalytically active core of bacterial cellulose synthase sufficient for in vitro cellulose synthesis. 24127606 Cellulose filaments have been visualized in situ via scanning electron and fluorescence microscopy. PMID: 2409795424127606 PMID: 24097954Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN160.123CYT0-0.200913-109Yn3-10c15/16o31-50i150-168o174-190i197-216o228-252i524-547o553-575i639-659o665-690iCytoplasmicMembrane10
BCSG_ECOLIP37659
bcsG

yhjU

yhjUb3538 JW3506 integral IM protein (SEC in IM), Cellulose biosynthesis BcsGIntegral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN520.108TMH09.60827-44No34-56i68-85o113-132i139-162oCytoplasmicMembrane1010
YHJV_ECOLIP37660
yhjV
b3539 JW3508 integral IM protein (SEC in IM), transport YhjVIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN340.111TMH010.9997-1111Ni20-40o46-64i95-118o138-155i167-185o205-227i247-267o294-318i339-362o368-389i401-422oCytoplasmicMembrane10
EPTB_ECOLIP37661
eptB

yhjW

yhjWb3546 JW5660 integral IM protein (SEC in IM), EptBIntegral Inner Membrane Disulfide bond-containing protein PMID: 25664544PMID: 15795227 PMID: 15919996 PMID: 25664544Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN380.136TMH011.408-55Ni12-30o42-65i77-103o123-140i161-178oCytoplasmicMembrane10
YHJX_ECOLIP37662
yhjX
b3547 JW3516 integral IM protein (SEC in IM), MFS-type transporter YhjX Integral Inner Membrane PMID: 23222720 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN400.124TMH010.8343-1212Ni12-33o45-66i78-95o101-122i134-154o166-186i216-237o249-270i282-301o307-329i341-360o366-387iCytoplasmicMembrane10
WECH_ECOLIP37669
wecH

yiaH

yiaHb3561 JW3533 integral IM protein (SEC in IM), O-acetyltransferase WecH Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECnoyesN330.129TMH07.27964-1010Ni12-29o49-67i79-102o114-131i143-160o172-190i202-224o236-255i267-288o300-321iCytoplasmicMembrane10
YIAM_ECOLIP37674
yiaM
b3577 JW3549 integral IM protein (SEC in IM), 2,3-diketo-L-gulonate TRAP transporter small permease YiaMIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN230.132TMH06.97669-44Ni7-28o40-59i80-101o113-137iCytoplasmicMembrane1013
YIAN_ECOLIP37675
yiaN
b3578 JW5651 integral IM protein (SEC in IM), 2,3-diketo-L-gulonate TRAP transporter large permease YiaNIntegral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN660.188TMH016.4337-1111No12-35i56-75o95-124i136-158o170-191i212-234o240-256i277-295o315-343i355-375o395-419iCytoplasmicMembrane10
YIAV_ECOLIP37683
yiaV
b3586 JW3558 integral IM protein (SEC in IM), YiaVIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBoutin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN160.116TMH01.11111-21Yn3-13c17/18o27-49iCytoplasmicMembrane1022
RFBX_ECOLIP37746
rfbX

wzx

wzxb2037 JW2022 integral IM protein (SEC in IM), Putative O-antigen transporter RfbXIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN510.11TMH08.627-1012Ni12-30o42-63i84-106o118-139i146-166o172-196i217-243o263-282i294-316o328-349i361-380o386-407iCytoplasmicMembrane10
RFC_ECOLIP37748
rfc

yefF

yefFb2035 JW2020 integral IM protein (SEC in IM), O-antigen polymerase RfcIntegral Inner Membrane Phobius prediction for a very very weak aminoterminal TMPMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN500.134TMH00.878412-1212Ni23-43o55-78i99-117o144-161i173-188o194-209i214-233o239-258i270-289o309-332i339-357o363-382iCytoplasmicMembrane10
NARU_ECOLIP37758
narU

yddF

yddFb1469 JW1464 integral IM protein (SEC in IM), Nitrate/nitrite transporter NarU Integral Inner Membrane PMID: 18691156 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN250.118CYT0-0.200913-1212Ni36-60o72-90i102-122o128-150i171-194o214-232i252-276o288-306i318-340o346-374i401-422o434-454iCytoplasmicMembrane10
YJFF_ECOLIP37772
yjfF
b4231 JW5754 integral IM protein (SEC in IM), ABC transporter permease YjfFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN310.156TMH09.53051-88No6-23i44-77o89-109i116-134o162-180i211-231o251-274i295-315oCytoplasmicMembrane10
YFJD_ECOLIP37908
yfjD

ypjE

ypjEb4461 JW5415 b2612/b2613integral IM protein (SEC in IM), UPF0053 YfjDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)noyesN240.142CYT0-0.200913-44No6-25i62-86o92-112i124-146oCytoplasmicMembrane1011
CUSA_ECOLIP38054
cusA

ybdE

ybdEb0575 JW0564 integral IM protein (SEC-YidC in IM), Cation efflux system CusAIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN390.202TMH06.2187-1212Ni12-32o338-357i364-384o390-411i442-464o484-505i538-554o874-891i898-918o924-948i985-1006o1012-1037iCytoplasmicMembrane10
YDJE_ECOLIP38055
ydjE
b1769 JW1758 integral IM protein (SEC in IM), metabolite transport YdjE Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN470.167TMH06.79423-1212Ni21-40o60-80i92-112o118-139i151-173o179-198i264-287o299-320i327-346o352-375i387-410o416-438iCytoplasmicMembrane10
DGCE_ECOLIP38097
dgcE

yegE

yegEb2067 JW2052 integral IM protein (SEC in IM), Probable diguanylate cyclase DgcEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN620.16TMH012.1449-1110Ni12-33o39-58i65-85o91-112i124-144o156-177i189-206o212-228i235-258o270-290iCytoplasmicMembrane10
EAMB_ECOLIP38101
eamB

yfiK

yfiKb2578 JW2562 integral IM protein (SEC in IM), Cysteine/O-acetylserine efflux protein EamBIntegral Inner Membrane PMID: 12562784 PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECnoyesN450.172TMH07.57291-65Yn4-15c27/28o43-67i74-91o111-133i140-163o175-194iCytoplasmicMembrane10
ETK_ECOLIP38134
etk

yccC

yccCb0981 JW0964 integral IM protein (SEC in IM), Tyrosine-kinase Etk Integral Inner Membrane PMID: 15919996 PMID: 10369665Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane protein Integral Membrane Protein(experimental)SRPSECnoyesN590.28CYT0-0.200913-22Ni33-51o425-445iCytoplasmicMembrane1041
LPLT_ECOLIP39196
lplT

ygeD

ygeDb2835 JW2803 integral IM protein (SEC in IM), Lysophospholipid transporter LplT Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.127TMH08.05882-1011No20-41i53-73o93-117i138-158o164-184i220-245o257-278i285-302o308-329i349-369o375-393iCytoplasmicMembrane10
YFCC_ECOLIP39263
yfcC
b2298 JW2295 integral IM protein (SEC in IM), Putative basic amino acid antiporter YfcC Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN490.144TMH03.89092-1113Ni20-41o106-127i148-165o171-187i194-221o233-252i287-308o314-332i353-371o383-403i410-432o452-471i483-503oCytoplasmicMembrane10
YJDF_ECOLIP39270
yjdF
b4121 JW4082 integral IM protein (SEC in IM), YjdFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN290.268TMH04.29363-66Ni7-26o32-49i61-83o103-120i132-155o175-194iCytoplasmicMembrane103
DTPC_ECOLIP39276
dtpC

yjdL

yjdLb4130 JW4091 integral IM protein (SEC in IM), Dipeptide and tripeptide permease C DtpCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN470.104TMH02.87637-1414Ni12-35o47-68i75-94o100-116i137-161o167-186i207-228o234-251i263-281o308-329i341-361o373-395i407-428o454-473iCytoplasmicMembrane10
YJEH_ECOLIP39277
yjeH
b4141 JW4101 integral IM protein (SEC in IM), L-methionine/branched-chain amino acid exporter YjeH Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN340.297TMH010.0553-1110Yn8-21c33/34o43-66i87-108o120-137i149-166o186-208i220-242o262-287i318-336o342-360i372-405oCytoplasmicMembrane10
YJEM_ECOLIP39282
yjeM
b4156 JW5739 integral IM protein (SEC in IM), transporter YjeMIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN260.324TMH013.0295-1211Yn10-18c23/24o39-62i83-110o130-149i161-183o203-223i244-264o311-336i357-381o393-412i432-454o466-484iCytoplasmicMembrane10
MSCM_ECOLIP39285
mscM

yjeP

yjePb4159 JW4120 integral IM protein (SEC in IM), Miniconductance mechanosensitive channel MscM Integral Inner Membrane PMID: 22874652Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesY200.667SpI198.61826-1111Yn3-14c19/20o476-496i517-539o551-576i597-617o629-649i670-691o697-718i785-808o828-848i879-897o903-930iCytoplasmicMembrane1015
ULAA_ECOLIP39301
ulaA

sgaT yjfS

sgaT yjfSb4193 JW5744 integral IM protein (SEC in IM), Ascorbate-specific PTS system EIIC component UlaAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN200.105TMH03.53199-1010No15-34i46-66o100-121i142-170o233-253i265-285o305-331i338-359o379-402i423-445oCytoplasmicMembrane10
YTFF_ECOLIP39314
ytfF
b4210 JW4168 integral IM protein (SEC in IM), YtfFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.128TMH08.9392-1010Ni5-25o31-52i64-86o92-113i125-142o154-175i195-216o231-255i262-281o287-306iCytoplasmicMembrane10
TAMB_ECOLIP39321
tamB

ytfN ytfO

ytfN ytfOb4221 JW4180 integral IM protein (SEC in IM), Translocation and assembly module subunit TamBIntegral Inner Membrane Part of the translocation and assembly module (TAM). TAM system promotes efficient secretion of autotransporters in proteobacteria.PMID: 22466966Integral Inner MembraneBBoutin/outN/ACell inner membrane Membrane anchoredSRPSECyesyesN240.143SpI257.57895-10Yn8-19c23/24oUnknown431
YTFT_ECOLIP39328
ytfT
b4230 JW5753 integral IM protein (SEC in IM), ABC transporter permease YtfTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN440.117TMH07.85185-1010Ni21-39o59-77i84-103o109-130i137-155o175-195i224-246o258-275i282-304o310-329iCytoplasmicMembrane10
YJGN_ECOLIP39338
yjgN
b4257 JW5759 integral IM protein (SEC in IM), YjgNIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN570.116TMH03.32963-88No24-45i65-90o96-116i142-164o176-208i229-249o280-299i327-349oCytoplasmicMembrane10
IDNT_ECOLIP39344
idnT

gntW yjgT

gntW yjgTb4265 JW4222 integral IM protein (SEC in IM), Gnt-II system L-idonate transporter IdnTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN460.134TMH010.8686-1212Ni12-38o58-76i97-130o136-154i175-194o222-242i254-275o295-312i324-344o350-369i376-393o413-438iCytoplasmicMembrane10
YJHB_ECOLIP39352
yjhB
b4279 JW5768 integral IM protein (SEC in IM), Putative metabolite transport YjhB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN170.101TMH07.56655-1112Ni21-41o53-73i85-105o111-129i141-160o166-185i215-235o247-271i283-302o308-327i339-362o368-392iCytoplasmicMembrane10
YJHF_ECOLIP39357
yjhF
b4296 JW4258 integral IM protein (SEC in IM), permease YjhFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN390.161TMH04.20538-1211Yn3-13c17/18o27-44i56-76o99-129i136-154o174-193i228-249o261-285i305-327o347-380i387-405o425-448iCytoplasmicMembrane10
SGCC_ECOLIP39365
sgcC

yjhN

yjhNb4304 JW4266 integral IM protein (SEC in IM), Putative permease IIC component SgcCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN330.12TMH010.5542-1111No6-25i32-54o85-109i130-152o172-194i214-235o247-268i289-319o325-344i353-374o408-430iCytoplasmicMembrane10
YJIJ_ECOLIP39381
yjiJ
b4332 JW4295 integral IM protein (SEC in IM), YjiJIntegral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN430.129TMH016.3295-1212Ni12-34o54-72i84-103o109-131i138-159o171-191i212-235o247-267i274-293o299-321i333-355o361-385iCytoplasmicMembrane10
YJIK_ECOLIP39382
yjiK
b4333 JW5869 integral IM protein (SEC in IM), YjiKBelongs to the yjiK family.Integral Inner MembraneBBoutin/outN/ACell membrane Membrane anchoredSRPSECnoyesN390.139SpI308.5892-11Ni12-28oUnknown231
YJIN_ECOLIP39385
yjiN
b4336 JW4299 integral IM protein (SEC in IM), YjiNIntegral Inner MembraneBBpolyin/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN470.127TMH011.0197-33Ni12-31o43-62i401-421oCytoplasmicMembrane9
MDTM_ECOLIP39386
mdtM

yjiO

yjiOb4337 JW4300 integral IM protein (SEC in IM), Multidrug resistance MdtMIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.289TMH07.71747-1211Yn9-20c24/25o48-68i80-99o105-126i138-162o168-187i216-241o253-271i283-304o310-335i347-368o374-395iCytoplasmicMembrane10
BTST_ECOLIP39396
btsT

yjiY

yjiYb4354 JW5791 integral IM protein (SEC in IM), Pyruvate/proton symporter BtsT Integral Inner Membrane PMID: 22685278 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN280.119TMH07.29235-1616Ni12-28o34-54i95-115o121-141i162-185o191-211i223-243o258-278i283-303o323-343i364-387o488-505i533-552o564-589i596-616o669-689iCytoplasmicMembrane10
LGOT_ECOLIP39398
lgoT

yjiZ yjjL

yjiZ yjjLb4356 JW4319 integral IM protein (SEC in IM), Probable L-galactonate transporter LgoTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN210.161CYT0-0.200913-1010Ni39-56o108-127i170-192o198-217i260-279o299-321i333-352o358-385i397-415o421-442iCytoplasmicMembrane10
OPGB_ECOLIP39401
mdoB

opgB yjjO

opgB yjjOb4359 JW5794 integral IM protein (SEC in IM), Phosphoglycerol transferase I MdoBIntegral Inner Membrane Disulfide bond-containing protein PMID: 25664544PMID: 15919996 PMID: 25664544Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN210.198TMH05.71979-44Yn4-14c18/19o28-47i59-74o80-98i110-128oCytoplasmicMembrane107
TTDT_ECOLIP39414
ttdT

ygjC ygjE

ygjC ygjEb3063 JW3035 integral IM protein (SEC in IM), L-tartrate/succinate antiporter TtdTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN300.161TMH015.2878-1214Ni7-27o33-49i56-73o93-116i137-154o192-214i235-258o289-307i312-328o340-364i371-391o397-415i422-442o462-486iCytoplasmicMembrane10
TORS_ECOLIP39453
torS

yccI

yccIb0993 JW5135 integral IM protein (SEC in IM), Sensor TorSIntegral Inner Membrane Trimethylamine N-oxide (TMAO) respiration system is encoded by the torCAD operon and comprises a periplasmic TMAO reductase (TorA) and a c-type cytochrome (TorC), which shuttles electrons to TorA. Interaction studies showed that, when immature, TorC can no longer bind TorA efficiently but can bind the periplasmic detector region of sensor TorS. The immature C-terminal domain of TorC strongly down-regulated the tor operon and interacted with the TorS detector region.PMID: 15919996 PMID: 11562502Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN270.124TMH08.89656-22No12-31i331-352oCytoplasmicMembrane1013
YBAL_ECOLIP39830
ybaL

ylaA

ylaAb0478 JW0467 integral IM protein (SEC in IM), Putative cation/proton antiporter YbaL Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECnoyesN260.134TMH05.87955-1212No6-26i33-51o57-76i88-112o118-136i148-168o180-206i227-260o280-299i306-328o334-361i368-387oCytoplasmicMembrane1036
ZNUB_ECOLIP39832
znuB

yebI

yebIb1859 JW1848 integral IM protein (SEC in IM), High-affinity zinc uptake system ZnuB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.205TMH013.4596-79No6-28i33-51o57-74i86-107o127-145i166-183o189-207i214-233o239-256iCytoplasmicMembrane10
GNTT_ECOLIP39835
gntT

gntM usgA yhgC

gntM usgA yhgCb3415 JW5690 integral IM protein (SEC in IM), High-affinity gluconate transporter GntTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN280.124TMH09.75395-119Yn3-16c34/35o58-76i97-130o136-154i175-194o224-246i258-278o298-316i337-370o416-437iCytoplasmicMembrane1014
YFEH_ECOLIP39836
yfeH
b2410 JW5876 integral IM protein (SEC in IM), Putative symporter YfeH Integral Inner MembraneBBpolyin/inIM (predicted)Integral Membrane ProteinSRPSECyesyesN290.211TMH06.99994-810Ni7-24o30-48i69-89o101-119i126-152o164-181i202-221o227-250i262-283o289-311iCytoplasmicMembrane10
RCSD_ECOLIP39838
rcsD

yojN yojP yojQ

yojN yojP yojQb2216 JW2204 integral IM protein (SEC in IM), Phosphotransferase RcsD Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECnoyesN450.148SpI406.36777-12No22-46i309-330oCytoplasmicMembrane1024
QSEC_ECOLIP40719
qseC

ygiY

ygiYb3026 JW2994 integral IM protein (SEC in IM), Sensor QseCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN350.271SpI349.27705-22Ni12-33o155-182iCytoplasmicMembrane1022
NANT_ECOLIP41036
nanT
b3224 JW3193 integral IM protein (SEC in IM), Sialic acid transporter NanT Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN580.109TMH03.96571-1214Ni21-43o55-74i86-106o112-134i146-165o171-190i224-242o248-267i274-292o312-334i343-361o367-391i403-425o431-452iCytoplasmicMembrane10
GSPF_ECOLIP41441
gspF

hofF hopF

hofF hopFb3327 JW3289 integral IM protein (SEC in IM), Putative type II secretion system F GspFIntegral Inner Membrane Part of gsp locus. Homolog to type two secretion system proteins PulF.PMID: 11118204 PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN670.101CYT0-0.200913-34Ni164-186o217-236i248-268o370-391iCytoplasmicMembrane1016
GSPG_ECOLIP41442
gspG

hofG hopG

hofG hopGb3328 JW3290 integral IM protein (SEC in IM), Putative type II secretion system G GspGIntegral Inner Membrane Homolog to major pilin PulG (T2SS). Potential component of type II secretion system. GspG is the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping of the periplasmic piston filaments to achieve secretion. TogetPMID: 20616068 PMID: 14966662 PMID: 11118204 PMID: 23006128 PMID: 18241884Integral Inner MembraneBBoutin/outIM (predicted)Membrane anchoredSRPSECnoyesN360.127CYT0-0.200913-11Ni12-34oCytoplasmicMembrane946
GSPH_ECOLIP41443
gspH

hofH hopH

hofH hopHb3329 JW3291 integral IM protein (SEC in IM), Putative type II secretion system H GspHIntegral Inner Membrane GspH is one of four low abundance pseudopillins together with GspI, J and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping of the periplasmic piston filaments to achieve sePMID: 18461043 PMID: 17172336 PMID: 18241884 PMID: 11118204 PMID: 23006128 PMID: 21890895Integral Inner MembraneB-N/AMembrane anchoredSECT2SnoyesN290.113TMH04.86781-11No12-31iCytoplasmicMembrane972
YGJI_ECOLIP42590
ygjI
b3078 JW5512 nucleoid & integral IM protein (SEC in IM), transporter YgjIIntegral Inner Membrane, NucleoidPMID: 23138451 PMID: 15919996Integral Inner Membrane, NucleoidB, Nin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.124TMH05.79735-1212Ni12-29o41-63i84-108o120-140i152-176o196-220i232-255o287-312i332-353o365-385i406-426o432-452iCytoplasmicMembrane10
ALX_ECOLIP42601
alx

ygjT

ygjTb3088 JW5515 integral IM protein (SEC in IM), Putative membrane-bound redox modulator Alx Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN360.24TMH011.5369-99No6-29i41-63o83-102i114-136o142-161i205-229o235-255i267-286o292-311iCytoplasmicMembrane10
YHAM_ECOLIP42626
yhaM

yhaN

yhaNb4470 JW5518 integral IM protein (SEC in IM), UPF0597 YhaMIntegral Inner MembraneBBoutout/inIM (predicted)CytoplasmicSRPSECpseudogene (Ochman & Davalos, 2006)yesnoN430.167CYT0-0.200913-01No319-340iCytoplasmic983
DLST_ECOLIP42628
dlsT

yhaO

yhaOb3110 JW5519 integral IM protein (SEC in IM), Probable serine transporter DlsTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN200.128TMH00.623427-1111Ni38-58o64-82i111-135o155-173i185-206o221-243i264-285o318-339i360-381o387-411i423-442oCytoplasmicMembrane10
YHBX_ECOLIP42640
yhbX
b3173 JW5534 integral IM protein (SEC in IM), Putative phosphoethanolamine transferase YhbX Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN320.175TMH013.1458-56Ni15-31o37-54i61-82o112-131i143-163o175-195iCytoplasmicMembrane10
PTPC2_ECOLIP42905
agaW
b3134 integral IM protein (SEC in IM), Putative N-acetylgalactosamine permease IIC component 2 AgaWIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006), pseudogene (Uniprot)noyesN700.132TMH06.59862-33No6-26i33-56o94-116iCytoplasmicMembrane109
PTPC1_ECOLIP42910
agaC

yraE

yraEb3139 JW3108 integral IM protein (SEC in IM), N-acetylgalactosamine permease IIC component 1 AgaCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN280.124TMH04.72274-64Yn4-15c20/21o97-121i142-164o184-202i209-238oCytoplasmicMembrane102
PTPD_ECOLIP42911
agaD

yraF

yraFb3140 JW3109 integral IM protein (SEC in IM), N-acetylgalactosamine permease IID component AgaDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN320.125CYT0-0.200913-55Ni96-119o131-151i172-195o215-236i243-262oCytoplasmicMembrane105
YNFM_ECOLIP43531
ynfM

yzyC

yzyCb1596 JW1588 integral IM protein (SEC in IM), transport YnfMIntegral Inner Membrane Phobius weak prediction of a hydrophobic TMIn the middle of sequence/Kyte-Doolittle predicts several hydrophobic patches.PMID: 3905795 PMID: 20608695 PMID: 19275539 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN530.119CYT0-0.200913-1212Ni37-59o71-91i103-122o128-149i156-175o187-208i240-261o267-285i306-323o329-352i364-386o392-411iCytoplasmicMembrane10
PQIB_ECOLIP43671
pqiB

pqi5B

pqi5Bb0951 JW0934 integral IM protein (SEC in IM), Intertransport PqiB Integral Inner Membrane PMID: 15919657Integral Inner MembraneBBoutin/outIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN420.124TMH06.02674-11Ni20-38oUnknown2
PITB_ECOLIP43676
pitB
b2987 JW2955 integral IM protein (SEC in IM), Probable low-affinity inorganic phosphate transporter 2 PitBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN410.141TMH010.6201-1011No6-26i52-76o96-116i123-143o155-177i208-227o233-255i343-361o381-402i423-442o474-495iCytoplasmicMembrane106
YRBG_ECOLIP45394
yrbG
b3196 JW3163 integral IM protein (SEC in IM), YrbGIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN260.208CYT0-0.200913-99Yn2-17c25/26o35-56i68-90o105-122i129-150o170-188i200-219o239-264i276-294o300-319iCytoplasmicMembrane10
DCUD_ECOLIP45428
dcuD

yhcL

yhcLb3227 JW3196 integral IM protein (SEC in IM), Putative cryptic C4-dicarboxylate transporter DcuD Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN300.172TMH02.68784-1312Ni26-48o68-89i109-128o134-150i157-174o194-215i242-265o271-290i348-369o375-397i409-430o436-454iCytoplasmicMembrane10
YRAQ_ECOLIP45468
yraQ
b3151 JW3120 integral IM protein (SEC in IM), UPF0718 YraQIntegral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell membrane Integral Membrane ProteinSRPSECnoyesN100.146TMH03.98221-99No15-32i72-95o115-134i146-167o173-191i227-249o261-280i287-305o325-345iCytoplasmicMembrane10
KEFB_ECOLIP45522
kefB

trkB

trkBb3350 JW3313 integral IM protein (SEC in IM), Glutathione-regulated potassium-efflux system KefB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN200.23TMH010.3228-1313No6-25i32-50o56-75i87-107o113-135i147-171o183-201i213-231o237-255i267-285o291-312i324-343o355-373iCytoplasmicMembrane10
YHFK_ECOLIP45537
yhfK
b3358 JW5701 integral IM protein (SEC in IM), YhfKIntegral Inner MembraneBBpolyout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN540.107TMH00.537733-911No38-55i67-85o91-108i115-133o139-160i371-388o394-411i418-435o441-457i464-481o487-509iCytoplasmicMembrane106
FRLA_ECOLIP45539
frlA

yhfM

yhfMb3370 JW3333 integral IM protein (SEC in IM), Probable fructoselysine/psicoselysine transporter FrlA Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN200.117TMH013.0134-1112Ni12-32o44-66i87-113o125-143i155-175o195-219i231-256o276-302i327-347o353-375i387-406o412-434iCytoplasmicMembrane10
YHFT_ECOLIP45546
yhfT
b3377 JW3340 integral IM protein (SEC in IM), YhfTIntegral Inner MembraneBBpolyout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN220.311TMH00.362704-1111No6-28i49-70o90-113i133-153o159-176i183-200o229-249i289-314o320-339i369-397o409-432iCytoplasmicMembrane10
XAPB_ECOLIP45562
xapB
b2406 JW2397 nucleoid & integral IM protein (SEC in IM), Xanthosine permease XapBIntegral Inner Membrane, NucleoidPMID: 15919996Integral Inner Membrane, NucleoidB, NBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN510.121TMH09.53241-1212Ni12-30o42-62i71-88o94-114i135-154o160-178i212-235o255-275i282-301o307-327i348-369o381-402iCytoplasmicMembrane10
GSPA_ECOLIP45756
gspA

yheD

yheDb3323 JW3285 integral IM protein (SEC in IM), Putative general secretion pathway A GspAIntegral Inner Membrane C-terminus of GspA is in the periplasm. The protein fractionates with the inner membrane. Part of gsp locus.PMID: 11118204 PMID: 21378198Integral Inner MembraneBBinoutin/outIM (predicted)Cell membrane Membrane anchoredSRPSECnoyesN370.16CYT0-0.200913-11Ni237-257oCytoplasmic975
GSPC_ECOLIP45757
gspC

yheE

yheEb3324 JW3286 integral IM protein (SEC in IM), Putative type II secretion system C GspCIntegral Inner Membrane Homolog to type two secretion system proteins PulC. Potential component of type II secretion system. A representative PulC-PhoA hybrid protein fractionated mainly with the inner membrane upon isopycnic sucrose gradient centrifugation of membrane vesicles. PMID: 2677007 GspC is the inner membrane component of type II secretion system (T2SS). GspD and the inner membrane protein GspC interact with each other via periplasmic domains (observed in the crystal structure). PMID: 21931548PMID: 14966662 PMID: 11118204 PMID: 2677007 PMID: 21931548Integral Inner MembraneBBinout/inN/ACell inner membrane Membrane anchoredSRPSECnoyesN180.127TMH0-0.020813-11No17-38iUnknown227
GSPI_ECOLIP45760
gspI

yheH

yheHb3330 JW5706 integral IM protein (SEC in IM), Putative type II secretion system I GspIIntegral Inner Membrane Potential component of type II secretion system. GspI is one of four low abundance pseudopillins together with GspH, J and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368PMID: 14966662 PMID: 11118204 PMID: 18241884 PMID: 23006128 PMID: 21890895 PMID: 11266368Integral Inner MembraneBBinout/inN/APeriplasmic (Experimental)SECT2SnoyesN240.233SpI233.86957-11No12-30iCytoplasmicMembrane960
GSPL_ECOLIP45763
gspL

yheK

yheKb3333 JW5705 integral IM protein (SEC in IM), Putative type II secretion system L GspLIntegral Inner Membrane Potential component of type II secretion system. EspL (GspL homolog) protein interacts through its N-terminal cytoplasmic domain with EspL (GspL homolog) proteinPMID: 14966662 PMID: 11118204 PMCID: PMC398259Integral Inner MembraneBBinoutin/outIM (predicted), Detected in IM FractionCell inner membrane CytoplasmicSRPSECnoyesN450.133CYT0-0.200913-01Ni242-260oUnknown217
YHDX_ECOLIP45767
yhdX
b3269 JW5544 integral IM protein (SEC in IM), Putative amino-acid ABC transporter permease YhdX Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN220.16TMH09.39948-88Ni21-40o92-114i126-146o181-200i220-241o261-280i335-353o359-384iCytoplasmicMembrane10
YHDY_ECOLIP45768
yhdY
b3270 JW5545 integral IM protein (SEC in IM), amino-acid ABC transporter permease YhdYIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN210.123TMH01.0833-88Ni28-46o98-119i126-148o160-182i194-219o231-250i292-315o335-352iCytoplasmicMembrane10
IGAA_ECOLIP45800
yrfF
b3398 JW3361 integral IM protein (SEC in IM), Putative IgaA homolog YrfFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN190.26SpI184.58634-55No6-22i206-223o229-247i337-358o652-674iCytoplasmicMembrane1026
YHGE_ECOLIP45804
yhgE
b3402 JW3365 integral IM protein (SEC in IM), YhgEIntegral Inner MembraneBBpolyin/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN440.113TMH010.0663-1111Ni12-33o39-59i66-84o99-118i138-163o183-201i213-236o248-268i289-308o320-341i353-373oCytoplasmicMembrane10
YCIQ_ECOLIP45848
yciQ

yciP

yciPb1268 JW5197 integral IM protein (SEC in IM), YciQIntegral Inner MembraneBBpolyout/inIM (predicted)Integral Membrane ProteinSRPSECnoyesY240.803SpI238.83165-55Yn7-18c23/24o249-266i398-423o429-448i460-480o486-513iCytoplasmicMembrane10
MTGA_ECOLIP46022
mtgA

mgt yrbM

mgt yrbMb3208 JW3175 integral IM protein (SEC in IM), Biosynthetic PG transglycosylase MtgAIntegral Inner MembraneBBoutin/outN/ACell inner membrane Membrane anchoredSRPSECyesyesN250.133TMH013.1588-11Ni21-41oCytoplasmicMembrane1011
YEDI_ECOLIP46125
yedI
b1958 JW1941 integral IM protein (SEC in IM), YedIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN300.143CYT0-0.200913-55Yn2-12c30/31o73-102i152-171o177-199i220-249o269-294iCytoplasmicMembrane104
ABGT_ECOLIP46133
abgT

ydaH

ydaHb1336 JW5822 ECK1332integral IM protein (SEC in IM), p-aminobenzoyl-glutamate transport AbgTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECnoyesN550.352TMH03.72666-1313Ni30-52o85-104i125-147o153-175i182-202o214-232i260-281o301-322i343-362o382-403i415-434o440-458i470-495oCytoplasmicMembrane10
YDDG_ECOLIP46136
yddG
b1473 JW1469 integral IM protein (SEC in IM), Aromatic amino acid exporter YddGIntegral Inner Membrane PMID: 21042032 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN240.109TMH07.54403-109Yn6-17c26/27o36-57i64-86o92-113i120-138o158-175i182-203o215-235i242-264o270-290iCytoplasmicMembrane10
DGCN_ECOLIP46139
dgcN

yfiN

yfiNb2604 JW2585 integral IM protein (SEC in IM), Diguanylate cyclase DgcNIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN670.12TMH011.5458-22Ni21-43o155-177iCytoplasmicMembrane10
AAEB_ECOLIP46481
aaeB

yhcP

yhcPb3240 JW3209 integral IM protein (SEC in IM), p-hydroxybenzoic acid efflux pump subunit AaeB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN540.637TMH06.80417-1010Ni13-32o38-56i68-87o93-112i119-135o371-395i407-426o432-449i461-480o486-503iCytoplasmicMembrane10
AAEA_ECOLIP46482
aaeA

yhcQ

yhcQb3241 JW3210 integral IM protein (SEC in IM), p-hydroxybenzoic acid efflux pump subunit AaeA Integral Inner Membrane PET family proteins are believed to be membrane localized, having 12 predicted transmembrane segments in gram-negative bacteria PMID: 10939244 PMID: 15489430PMID: 10939244 PMID: 15489430Integral Inner MembraneBBoutin/outN/ACell inner membrane Periplasmic (Experimental)SRPSECyesyesN310.144SpI288.87913-11Ni12-32oCytoplasmicMembrane9
FTSK_ECOLIP46889
ftsK
b0890 JW0873 nucleoid & integral IM protein (SEC in IM), DNA translocase FtsKIntegral Inner Membrane, NucleoidPMID: 9723913 PMID: 11703663 PMID: 11948172 PMID: 15919996Integral Inner Membrane, NucleoidB, NBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN530.169TMH06.50875-55Ni25-44o75-98i110-131o137-158i165-184oCytoplasmicMembrane1014
AER_ECOLIP50466
aer

air yqjJ

air yqjJb3072 JW3043 integral IM protein (SEC-YidC in IM), Aerotaxis receptor AerIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 22380631 PMID: 15919996Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSEC-YidCyesyesN340.205CYT0-0.200913-11Ni171-200oCytoplasmicMembrane1031
TORY_ECOLIP52005
torY

yecK

yecKb1873 JW1862 integral IM protein (SEC in IM), Cytochrome c-type TorYIntegral Inner Membrane Part of the anaerobic respiratory chain of trimethylamine-N-oxide reductase TorZ. Required for electron transfer to the TorZ terminal enzyme. PMID: 11004177 PMID: 11004177Integral Inner MembraneBBoutin/outN/ACell inner membrane Periplasmic with N-terminal membrane anchor (Experimental)SRPSECyesyesN320.123SpI267.35562-10Yn7-18c26/27oUnknown444
FSR_ECOLIP52067
fsr
b0479 JW0468 integral IM protein (SEC in IM), Fosmidomycin resistance protein FsrIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN290.107TMH04.87385-1011No26-50i62-84o104-130i151-175o181-202i223-242o262-282i294-313o319-340i352-375o381-399iCytoplasmicMembrane10
HISQ_ECOLIP52094
hisQ
b2308 JW2305 integral IM protein (SEC in IM), Histidine transport system permease HisQ Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN280.408TMH06.17401-55No12-35i47-70o90-108i149-171o191-215iCytoplasmicMembrane108
GLRK_ECOLIP52101
glrK

yfhK

yfhKb2556 JW5407 integral IM protein (SEC in IM), Sensor histidine kinase GlrKIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBinoutout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.258SpI308.61403-21Yn14-24c30/31o174-198iCytoplasmicMembrane1018
YFJW_ECOLIP52138
yfjW
b2642 JW2623 integral IM protein (SEC in IM), YfjWIntegral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)nonoN470.122TMH06.6613-56Ni20-46o66-89i96-118o130-151i163-188o536-557iCytoplasmicMembrane10
EMRY_ECOLIP52600
emrY
b2367 JW2364 integral IM protein (SEC-YidC in IM), Probable multidrug resistance EmrY Integral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN400.184TMH010.5527-1313Ni12-32o55-73i85-104o110-132i144-165o171-193i205-224o236-255i276-295o307-325i337-355o375-394i484-502oCytoplasmicMembrane10
YCCM_ECOLIP52636
yccM
b0992 JW0977 integral IM protein (SEC in IM), Putative electron transport YccM Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN480.107CYT0-0.200913-55Ni37-54o96-114i159-180o200-218i307-332oCytoplasmicMembrane1012
YDBH_ECOLIP52645
ydbH
b1381 JW1376 integral IM protein (SEC in IM), YdbHUncharacterized, echolocation Signal peptide may be membrane anchored or cleaved and the protein therefore exported (signalP score near threshold). BOMP reliability scores are below 2 and so this is unlikely to be an OMP.Integral Inner MembraneBBoutin/outN/AMembrane anchoredSRPSECnoyesN350.163TMH06.49797-10Yn7-26c34/35oCytoplasmicMembrane912
YBHD_ECOLIP52696
ybhD
b0768 JW5896 nucleoid & integral IM protein (SEC in IM), HTH-type transcriptional regulator YbhDIntegral Inner Membrane, Nucleoid Uncharacterized HTH-type transcriptional regulator Integral Inner Membrane, NucleoidB, NN/AMembrane anchoredSRPSECnoyesN240.184CYT0-0.200913-11Ni94-112oCytoplasmic9
MNGA_ECOLIP54745
mngA

hrsA

hrsAb0731 JW0720 integral IM protein (SEC in IM), PTS system 2-O-alpha-mannosyl-D-glycerate-specific EIIABC component MngAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN370.104CYT0-0.200913-98Ni310-337o357-376i388-414o434-454i466-486o498-518i574-596o616-641iCytoplasmicMembrane1037
YGCG_ECOLIP55140
ygcG
b2778 JW5445 integral IM protein (SEC in IM), UPF0603 YgcGIntegral Inner MembraneBBpoly-IM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesY180.242SpI174.90841-23Yn4-12c17/18o176-194i206-222o228-249iCytoplasmicMembrane10
YGAP_ECOLIP55734
ygaP
b2668 JW2643 integral IM protein (SEC in IM), YgaPIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN120.121CYT0-0.200913-22Ni117-135o141-165iCytoplasmicMembrane1028
CYDX_ECOLIP56100
cydX

ybgT

ybgTb4515 JW0724 integral IM protein (SEC-YidC in IM), Cytochrome bd-I ubiquinol oxidase subunit X CydXIntegral Inner Membrane Found to co-fractionate with the inner membrane. Experimentally verified orientation: N(out)-C(in). Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreased.PMID: 19121005 PMID: 21778229Integral Inner MembraneBBinoutin/outN/ACell inner membrane CytoplasmicSRPSEC-YidCnoyesN240.168SpI233.08714-10Yn4-15c23/24oUnknown2
PTHC_ECOLIP56579
srlA

gutA sbl

gutA sblb2702 JW5429 integral IM protein (SEC in IM), PTS system glucitol/sorbitol-specific EIIC component SrlAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN460.112CYT0-0.200913-33No22-48i69-91o122-149iCytoplasmicMembrane1017
PTHB_ECOLIP56580
srlE

gutA gutE

gutA gutEb2703 JW5430 integral IM protein (SEC in IM), PTS system glucitol/sorbitol-specific EIIB component SrlEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECnoyesN220.109CYT0-0.200913-46Ni147-165o177-197i204-226o232-250i257-280o300-318iCytoplasmicMembrane1017
ADIC_ECOLIP60061
adiC

aniC yjdD yjdE

aniC yjdD yjdEb4115 JW4076 integral IM protein (SEC in IM), Arginine/agmatine antiporter AdiCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN620.127TMH08.65108-1212Ni12-35o41-61i91-116o122-141i153-173o193-217i229-254o274-296i317-340o352-374i386-404o410-428iCytoplasmicMembrane10
MSBA_ECOLIP60752
msbA
b0914 JW0897 integral IM protein (SEC in IM), Lipid A export ATP-binding/permease MsbAIntegral Inner Membrane PMID: 8809774 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN390.127TMH07.05231-56Ni21-45o65-93i142-163o169-186i244-269o275-295iCytoplasmicMembrane1011
TSGA_ECOLIP60778
tsgA

gutS yhfC yhfH

gutS yhfC yhfHb3364 JW3327 integral IM protein (SEC in IM), TsgAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.126TMH017.4563-1212Ni12-35o47-66i78-97o103-122i134-157o163-183i204-229o249-268i273-289o295-317i329-352o358-381iCytoplasmicMembrane10
PLSY_ECOLIP60782
plsY

ygiH

ygiHb3059 JW3031 integral IM protein (SEC in IM), Probable glycerol-3-phosphate acyltransferase PlsYIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.12TMH01.31378-55No6-28i49-68o80-102i109-132o138-158iCytoplasmicMembrane1017
AQPZ_ECOLIP60844
aqpZ

bniP

bniPb0875 JW0859 integral IM protein (SEC-YidC in IM), Aquaporin Z AqpZIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidCPMID: 22108384. AqpZ forms tetramer in the inner membranePMID: 14691544. Sucrose gradient sedimentation analysis showed that the native, solubilized AqpZ protein is a trypsin-resistant tetramerPMID: 10518952. Upon reconstitution into proteoliposomes, AqpZ displays very high osmotic water permeability. No permeation by glycerol, urea or sorbitol was detectedPMID: 10518952. Electron crystallography has shown monomers to consist of six membrane spanning alpha-helices confirming sequence based predictionsPMID: 10487750.PMID: 11266632 PMID: 14691544 PMID: 22108384 PMID: 10518952 PMID: 10487750 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN430.268TMH014.8231-65Yn5-17c26/27o36-60i81-103o129-149i161-180o206-226iCytoplasmicMembrane10
YBJL_ECOLIP60869
ybjL
b0847 JW0831 integral IM protein (SEC in IM), Putative transport YbjL Integral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN230.115TMH04.04335-910No12-30i37-55o61-85i92-114o161-181i383-403o409-426i447-464o476-498i532-557oCytoplasmicMembrane10
YIDE_ECOLIP60872
yidE

yibE

yibEb3685 JW3662 integral IM protein (SEC in IM), Putative transport YidE Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell membrane Integral Membrane ProteinSRPSECyesyesN270.131TMH07.15912-1011No6-22i29-47o67-86i93-115o162-182i371-391o397-417i429-446o466-485i492-513o533-552iCytoplasmicMembrane10
UPPP_ECOLIP60932
uppP

bacA upk

bacA upkb3057 JW3029 integral IM protein (SEC in IM), Undecaprenyl-diphosphatase UppPIntegral Inner Membrane PMID: 15138271 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN460.112TMH02.62176-77Yn6-13c18/19o50-69i90-110o116-136i157-175o195-213i225-246o252-272iCytoplasmicMembrane10
LGT_ECOLIP60955
lgt

umpA

umpAb2828 JW2796 integral IM protein (SEC in IM), Prodiacylglyceryl transferase LgtIntegral Inner Membrane PMID: 8051048 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN380.128TMH09.00412-57No14-40i60-80o100-118i130-148o200-218i225-242o262-282iCytoplasmicMembrane1010
OPGH_ECOLIP62517
mdoH

opgH

opgHb1049 JW1037 integral IM protein (SEC in IM), Glucans biosynthesis glucosyltransferase H MdoHIntegral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. OpgH localizes to the nascent septal site, where it antagonizes assembly of the tubulin-like cell division protein FtsZ, delaying division and increasing cell size.PMID: 9008159 PMID: 15919657 PMID: 15919996 PMCID: PMC3723540Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRP (exp)SECyesyesN350.119CYT0-0.200913-68Ni139-156o188-221i512-533o566-590i599-617o623-640i660-676o682-706iCytoplasmicMembrane103
YEIH_ECOLIP62723
yeiH
b2158 JW2145 integral IM protein (SEC in IM), UPF0324 YeiHIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN410.241TMH013.02-811Ni12-32o38-58i79-98o104-122i134-151o163-185i197-219o225-246i266-284o290-311i323-344oCytoplasmicMembrane10
KUP_ECOLIP63183
kup

trkD

trkDb3747 JW5609 integral IM protein (SEC in IM), Low affinity potassium transport system kup Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)yesyesN230.142TMH05.56396-1211Yn9-17c22/23o48-69i102-129o141-157i169-190o210-233i245-267o287-316i337-357o363-383i395-413o419-440iCytoplasmicMembrane10
GADC_ECOLIP63235
gadC

acsA xasA

acsA xasAb1492 JW1487 integral IM protein (SEC in IM), Probable glutamate/gamma-aminobutyrate antiporter GadCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN290.285TMH015.6618-1212Ni12-30o42-66i87-108o128-146i158-178o198-217i238-260o288-310i337-356o368-392i413-432o444-466iCytoplasmicMembrane10
YQEG_ECOLIP63340
yqeG
b2845 JW2813 integral IM protein (SEC in IM), transport YqeGIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN230.142TMH09.79347-1011Ni12-30o36-53i92-112o124-145i152-173o193-216i236-261o281-302i334-355o361-381i390-408oCytoplasmicMembrane10
ZNTB_ECOLIP64423
zntB

ydaN

ydaNb1342 JW1336 integral IM protein (SEC in IM), Zinc transport ZntB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN250.108CYT0-0.200913-22Ni268-289o301-321iCytoplasmicMembrane1082
YPFJ_ECOLIP64429
ypfJ
b2475 JW2460 integral IM protein (SEC in IM), YpfJIntegral Inner MembraneBBoutin/outIM (predicted)Membrane Membrane anchoredSRPSECyesyesN330.101CYT0-0.200913-11Ni38-58oUnknown2
YPJD_ECOLIP64432
ypjD
b2611 JW2592 integral IM protein (SEC in IM), YpjDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN180.156CYT0-0.200913-87Yn3-12c17/18o33-51i63-84o90-112i124-146o176-198i210-226o238-258iCytoplasmicMembrane10
YECN_ECOLIP64515
yecN
b1869 JW5308 integral IM protein (SEC in IM), YecNIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Single-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN210.119CYT0-0.200913-32Yn4-14c18/19o72-92i104-122oCytoplasmicMembrane1050
YGGT_ECOLIP64564
yggT
b2952 JW2919 integral IM protein (SEC in IM), YggTPotential substrate of periplasmic chaperone YfgM. PMID: 25403562Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell membrane Integral Membrane ProteinSRPSECYfgMyesyesN310.194TMH00.565687-44No6-25i67-91o97-119i144-165oCytoplasmicMembrane105
YQJD_ECOLIP64581
yqjD
b3098 JW3069 integral IM protein (SEC in IM), YqjDIntegral Inner MembraneYqJD is expressed during the stationary growth phase. YqjD possesses a transmembrane motif in the C-terminal region and associates with 70S and 100S ribosomes at the N-terminal region. Expressed during the stationary growth phase, and expression is regulated by stress response sigma factor RpoS. YqjD possesses a transmembrane motif in the C-terminal region and associates with 70S and 100S ribosomes at the N-terminal region. PMID: 22661687 YqjD is an inner membrane protein associated with stationary-phase ribosomes. PMID: 22661687PMID: 22661687 PMID: 22380631Integral Inner MembraneBBoutIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECnoyesN330.103CYT0-0.200913-11No81-99iUnknown2
MLAE_ECOLIP64606
mlaE

yrbE

yrbEb3194 JW3161 integral IM protein (SEC in IM), Interphospholipid transport system permease MlaE Integral Inner Membrane PMID: 19383799 PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN670.105CYT0-0.200913-56Ni48-69o75-96i103-125o148-177i198-219o239-258iCytoplasmicMembrane10
YGDQ_ECOLIP67127
ygdQ
b2832 JW2800 integral IM protein (SEC in IM), UPF0053 YgdQIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN490.35TMH03.66789-77No12-38i50-71o77-101i122-141o153-172i184-201o213-230iCytoplasmicMembrane1017
YHGN_ECOLIP67143
yhgN
b3434 JW3397 integral IM protein (SEC in IM), UPF0056 YhgNIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN260.114CYT0-0.200913-66No6-27i39-57o63-85i106-127o139-162i174-195oCytoplasmicMembrane1037
YQFA_ECOLIP67153
yqfA
b2899 JW2867 integral IM protein (SEC in IM), UPF0073 YqfAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN490.173TMH03.45027-77Ni21-42o54-74i86-105o111-132i139-157o163-186i195-216oCytoplasmicMembrane10
XANQ_ECOLIP67444
xanQ

ygfO

ygfOb2882 JW2850 integral IM protein (SEC in IM), Xanthine permease XanQ Integral Inner Membrane PMID: 16096267 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN590.123CYT0-0.200913-1212Ni24-50o56-74i81-104o116-142i154-175o187-204i211-231o251-275i338-360o366-388i395-412o424-446iCytoplasmicMembrane10
AAER_ECOLIP67662
aaeR

yhcS

yhcSb3243 JW3212 nucleoid & integral IM protein (SEC in IM), HTH-type transcriptional activator AaeRIntegral Inner Membrane, NucleoidPMID: 23138451Integral Inner Membrane, NucleoidB, NIM (predicted)CytoplasmicSRPSECyesyesN240.199CYT0-0.200913-01Ni226-245oCytoplasmic9
YFEO_ECOLIP67729
yfeO
b2389 JW2386 integral IM protein (SEC in IM), Putative ion-transport YfeO Integral Inner MembraneBBpolyin/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN190.188TMH012.9661-1111Ni12-37o57-77i98-117o147-170i182-203o223-245i257-281o301-318i325-340o346-364i371-398oCytoplasmicMembrane10
MALG_ECOLIP68183
malG
b4032 JW3992 integral IM protein (SEC in IM), Maltose/maltodextrin transport system permease MalG Integral Inner Membrane Signal recognition particle is required for insertion in the bacterial inner membrane. SRP pathway inhibition blocks membrane insertion. Crystal structure of a catalytic intermediate of the maltose transporter. PMID: 18033289PMID: 9008159 PMID: 2233678 PMID: 18456666 PMID: 15919996 PMID: 18033289Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRP (exp)SECnoyesN370.136TMH014.3943-66Ni12-39o91-110i122-143o163-181i202-227o258-281iCytoplasmicMembrane10
ATPL_ECOLIP68699
atpE

papH uncE

papH uncEb3737 JW3715 integral IM protein (YidC in IM), ATP synthase subunit c AtpEIntegral Inner Membrane Experimentally verified gene-productPMID: 9868784. Methionine start codon is cleavedPMID: 9868784. Fractionation analysis indicates that upon YidC depletion the protein membrane localization is significantly decreasedPMID: 15263011PMID: 21778229. PMID: 9237612PMID: 9868784 PMID: 15263011 PMID: 21778229 PMID: 15919996 PMID: 9237612Integral Inner MembraneBBpolyout/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane Protein (Experimental)SRPYidCnoyesN280.117TMH07.95599-22No12-32i53-76oCytoplasmicMembrane1056
DHSC_ECOLIP69054
sdhC

cybA

cybAb0721 JW0711 integral IM protein (SEC in IM), Succinate dehydrogenase cytochrome b556 subunit SdhCIntegral Inner Membrane Alpha-helcal transmembrane protein (experimental). Transmembrane helices: 3 PMID: 12560550.PMID: 11266632 PMID: 12560550 PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN270.129TMH01.73943-33Ni20-48o68-89i110-128oCytoplasmicMembrane1042
MDTI_ECOLIP69210
mdtI

ydgE

ydgEb1599 JW1591 integral IM protein (SEC in IM), Spermidine export MdtI Integral Inner Membrane PMID: 15919996 PMID: 24688744Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN560.185TMH03.45748-44No6-25i37-56o62-84i91-108oCytoplasmicMembrane1014
MDTH_ECOLIP69367
mdtH

yceL

yceLb1065 JW1052 integral IM protein (SEC in IM), Multidrug resistance MdtHIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN80.11TMH012.8944-1012Ni12-35o41-58i78-94o100-116i136-157o163-185i210-235o247-264i276-294o300-317i337-357o369-388iCytoplasmicMembrane10
FIEF_ECOLIP69380
fieF

yiiP

yiiPb3915 JW3886 integral IM protein (SEC in IM), Ferrous-iron efflux pump FieF Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.141TMH03.82255-66Ni12-33o39-60i81-106o118-138i158-175o181-199iCytoplasmicMembrane10
TATC_ECOLIP69423
tatC

mttB yigU yigV

mttB yigU yigVb3839 JW3815 integral IM protein (SEC-YidC in IM), Sec-independent translocase TatC Integral Inner Membrane PMID: 11591389 PMID: 15225613 PMID: 20169075 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN390.339TMH04.27208-66Ni20-38o74-95i116-137o157-183i195-212o218-237iCytoplasmicMembrane1065
TATB_ECOLIP69425
tatB

mttA2 ysgB

mttA2 ysgBb3838 JW5580 integral IM protein (SEC in IM), Sec-independent translocase TatB Integral Inner Membrane PMID: 11591389 PMID: 15225613 PMID: 20169075 PMID: 14580344Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane Membrane anchored (Experimental)SRPSECyesyesN440.115CYT0-0.200913-10Yn9-20c28/29oCytoplasmicMembrane10
TATA_ECOLIP69428
tatA

mttA1 yigT

mttA1 yigTb3836 JW3813 integral IM protein (SEC in IM), Sec-independent translocase TatA Integral Inner Membrane TatA-GFP was distributed in the membrane, often with higher abundance at the poles. PMID: 14580344PMID: 11591389 PMID: 15225613 PMID: 20169075 PMID: 14580344Integral Inner MembraneBBinout/inIM (predicted), Detected in IM FractionCell inner membrane Membrane anchored (Experimental)SRPSECyesyesN430.112CYT0-0.200913-11No6-22iCytoplasmicMembrane10
CCME_ECOLIP69490
ccmE

yejS

yejSb2197 JW2185 integral IM protein (SEC in IM), Cytochrome c-type biogenesis CcmEIntegral Inner Membrane CcmC, CcmE, and heme interact directly with each other, establishing a periplasmic heme delivery pathway for cytochrome c maturation. PMID: 11384983 PMID: 9770295 PMID: 16364305PMID: 11384983 PMID: 9770295 PMID: 16364305Integral Inner MembraneBBoutin/outN/ACell inner membrane Periplasmic with N-terminal membrane anchor (Experimental)SRPSECyesyesN290.181TMH08.60358-11Ni9-30oCytoplasmic866
AMTB_ECOLIP69681
amtB

ybaG

ybaGb0451 JW0441 integral IM protein (SEC-YidC in IM), Ammonia channel AmtBIntegral Inner Membrane Exhibites aberrant localization by microscopy in the absence of YidC. PMID: 9720863 PMID: 10231487 PMID: 11847102 PMID: 14668330PMID: 11266632 PMID: 15361618 PMID: 22108384 PMID: 11847102 PMID: 15919996 PMID: 9720863 PMID: 10231487 PMID: 14668330Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSEC-YidCyesyesY230.645SpI2212.8449-1211Yn3-14c22/23o32-54i66-86o120-142i149-171o183-205i217-236o248-268i280-297o303-324i336-356o376-396iCytoplasmicMembrane10
PTGCB_ECOLIP69786
ptsG

glcA umg

glcA umgb1101 JW1087 integral IM protein (SEC in IM), PTS system glucose-specific EIICB component PtsGIntegral Inner Membrane PMID: 12717030 PMID: 15650111 PMID: 15919657 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN380.133TMH012.5578-109No16-39i51-71o77-101i113-132o152-172i254-272o278-297i304-331o354-376iCytoplasmicMembrane103
PTNC_ECOLIP69801
manY

pel ptsP

pel ptsPb1818 JW1807 integral IM protein (SEC in IM), PTS system mannose-specific EIIC component ManYIntegral Inner Membrane PTS transport system component and membrane localized in complexomics study by (Stenberg et al., 2005)PMID: 15911532 PMID: 16079137 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN260.11TMH06.083-77No6-24i33-56o62-86i98-124o144-165i177-197o209-239iCytoplasmicMembrane10
PTND_ECOLIP69805
manZ

gptB ptsM

gptB ptsMb1819 JW1808 integral IM protein (SEC in IM), PTS system mannose-specific EIID component ManZIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell inner membrane Integral Membrane ProteinSRPSECyesyesN420.108CYT0-0.200913-33Ni130-154o238-255i262-282oCytoplasmicMembrane1029
PTMCB_ECOLIP69826
cmtA
b2933 JW2900 integral IM protein (SEC-YidC in IM), PTS system mannitol-specific cryptic EIICB component CmtAIntegral Inner Membrane Mannitol-specific cryptic phosphotransferase enzyme IIA component. Exhibites aberrant localization by microscopy in the absence of YidC.PMID: 12558186 PMID: 9525892 PMID: 9260961 PMID: 22108384 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSEC-YidCyesyesN510.119TMH014.5212-88Ni12-40o52-74i86-114o134-158i214-235o247-266i287-307o313-335iCytoplasmicMembrane10
PTKC_ECOLIP69831
gatC
b2092 JW2076 integral IM protein (SEC in IM), PTS system galactitol-specific EIIC component GatCIntegral Inner Membrane PTS system galactitol-specific EIIC component.The galactitol phosphotransferase system transporter (EIIGat) is also composed of three subunits, GatA (IIAGat), GatB (IIBGat), and GatC (IICGat). These three subunits assemble in a 1:1:2 stoichiometry to form a complex with a predicted molecular mass of ???122 kDaPMID: 16079137 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECpseudogene (Uniprot)noyesN340.145TMH00.817461-1111No12-29i41-58o91-113i134-158o178-198i218-239o245-264i298-322o328-346i353-371o417-435iCytoplasmicMembrane10
SUGE_ECOLIP69937
sugE
b4148 JW5738 integral IM protein (SEC in IM), Quaternary ammonium compound-resistance SugE Integral Inner Membrane Dual topology membrane protein: can insert into the membrane in both directions. PMID: 15919996PMID: 14728684 PMID: 15919996 PMID: 24688744 PMID: 16429150Integral Inner MembraneBBpolyin/out, out/inIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN610.195TMH010.6118-43Yn4-12c17/18o33-50i57-79o85-103iCytoplasmicMembrane10
WCAD_ECOLIP71238
wcaD
b2056 JW2041 integral IM protein (SEC in IM), Putative colanic acid polymerase WcaDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN260.141TMH02.50534-1111Ni7-25o31-48i55-73o85-105i117-138o172-191i203-226o246-266i278-296o328-347i368-397oCytoplasmicMembrane10
WCAJ_ECOLIP71241
wcaJ
b2047 JW2032 integral IM protein (SEC in IM), UDP-glucose:undecaprenyl-phosphate glucose-1-phosphate transferase WcaJIntegral Inner Membrane PMID: 22408159 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN320.107TMH04.26813-55Ni12-34o46-69i81-101o113-137i279-300oCytoplasmicMembrane10
YAGG_ECOLIP75683
yagG
b0270 JW0263 integral IM protein (SEC in IM), Putative glycoside/cation symporter YagG Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECProphage Integrase (EcoGene)yesnoN580.129TMH04.66722-1212Ni12-34o40-59i80-101o107-130i150-172o178-199i233-255o267-287i294-311o317-340i360-384o404-426iCytoplasmicMembrane10
YAHN_ECOLIP75693
yahN
b0328 JW0320 integral IM protein (SEC in IM), YahNIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN200.167TMH06.85455-66No20-42i54-79o85-103i136-153o159-179i199-217oCytoplasmicMembrane1045
ALLP_ECOLIP75712
ybbW

glxB2

glxB2b0511 JW0499 integral IM protein (SEC in IM), Putative allantoin permease YbbWIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN430.107TMH01.55234-1212Ni46-79o91-110i117-139o151-174i186-212o224-245i266-288o308-328i349-367o373-397i417-439o451-468iCytoplasmicMembrane10
DTPD_ECOLIP75742
dtpD

ybgH

ybgHb0709 JW0699 integral IM protein (SEC in IM), Dipeptide permease D DtpDIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN480.16TMH01.28832-1414Ni12-36o48-69i78-96o102-121i142-162o168-187i208-231o237-255i267-284o304-332i344-365o377-398i410-430o462-479iCytoplasmicMembrane10
ABRB_ECOLIP75747
abrB

ybgN

ybgNb0715 JW5097 ECK0704integral IM protein (SEC in IM), Putative regulator AbrB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN230.182TMH011.997-79No6-32i53-75o81-103i144-162o174-200i207-224o230-247i259-280o323-343iCytoplasmicMembrane10
ZITB_ECOLIP75757
zitB

ybgR

ybgRb0752 JW0735 integral IM protein (SEC in IM), Zinc transporter ZitB Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN520.121TMH05.6947-56Ni21-41o47-68i89-110o122-143i155-182o188-205iCytoplasmicMembrane10
YBHI_ECOLIP75763
ybhI
b0770 JW0753 integral IM protein (SEC in IM), YbhIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN270.378TMH013.1359-1514Ni7-25o31-48i55-71o91-108i120-141o147-166i178-198o218-244i273-291o297-315i327-345o365-381i388-415o445-468iCytoplasmicMembrane10
YBHN_ECOLIP75770
ybhN
b0788 JW0771 integral IM protein (SEC in IM), YbhNIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN320.118TMH010.4723-87Yn14-27c31/32o47-65i85-106o126-151i163-186o206-227i234-266o286-303iCytoplasmicMembrane10
YBHG_ECOLIP75777
ybhG
b0795 JW0779 integral IM protein (SEC in IM), UPF0194 YbhGIntegral Inner Membrane PMID: 17446557Integral Inner MembraneB0Soluble IM FractionPeriplasm Membrane anchoredSRPSECyesyesN260.132SpI206.65671-10Yn6-16c20/21oCytoplasmicMembrane931
YBIO_ECOLIP75783
ybiO
b0808 JW5108 integral IM protein (SEC in IM), Moderate conductance mechanosensitive channel YbiO Integral Inner Membrane PMID: 22874652 PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesY190.624SpI1812.9319-1111Yn3-13c18/19o141-163i183-205o225-244i268-286o292-315i335-361o381-399i419-446o466-488i509-531o537-559iCytoplasmicMembrane1022
OPGE_ECOLIP75785
opgE

ybiP

ybiPb0815 JW0800 integral IM protein (SEC in IM), Phosphoethanolamine transferase OpgE Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane Protein (Experimental)SRPSECyesyesN220.112TMH06.83717-44No34-54i63-84o104-127i139-158oCytoplasmicMembrane106
YBIR_ECOLIP75788
ybiR
b0818 JW0802 integral IM protein (SEC in IM), YbiRIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN390.126TMH06.01785-910No14-32i44-64o84-108i120-140o160-182i202-217o223-241i248-268o312-335i347-369oCytoplasmicMembrane10
GSIC_ECOLIP75798
gsiC

yliC

yliCb0831 JW0815 integral IM protein (SEC in IM), Glutathione transport system permease GsiC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN400.137TMH06.79337-66Ni9-30o99-123i135-155o170-191i227-249o278-299iCytoplasmicMembrane102
GSID_ECOLIP75799
gsiD

yliD

yliDb0832 JW0816 integral IM protein (SEC in IM), Glutathione transport system permease GsiD Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN660.123CYT0-0.200913-66Ni40-61o103-129i136-158o164-183i222-247o267-290iCytoplasmicMembrane1010
PDEI_ECOLIP75800
pdeI

yliE

yliEb0833 JW0817 integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell membrane Integral Membrane ProteinSRPSECnoyesN280.121TMH01.46888-22Ni12-32o286-304iCytoplasmicMembrane74
DGCI_ECOLIP75801
dgcI

yliF

yliFb0834 JW0818 integral IM protein (SEC in IM), Probable diguanylate cyclase DgcIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBinoutout/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN240.568SpI237.00044-21Yn7-17c25/26o231-251iCytoplasmicMembrane1010
YBJG_ECOLIP75806
ybjG
b0841 JW5112 integral IM protein (SEC in IM), Putative undecaprenyl-diphosphatase YbjG Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.216TMH02.64993-45No20-48i60-80o100-119i126-144o150-168iCytoplasmicMembrane109
YBJJ_ECOLIP75810
ybjJ
b0845 JW0829 integral IM protein (SEC in IM), YbjJIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN300.184TMH016.9774-1212Ni15-32o52-71i78-98o104-124i145-164o170-187i217-234o254-275i282-301o307-328i340-358o370-389iCytoplasmicMembrane10
YBJT_ECOLIP75822
ybjT
b0869 JW5116 integral IM protein (SEC in IM), Putative NAD(P)-binding YbjTIntegral Inner MembraneBBoutout/inIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN200.113CYT0-0.200913-11No446-464iCytoplasmicMembrane918
LYSO_ECOLIP75826
lysO

ybjE

ybjEb0874 JW0858 integral IM protein (SEC in IM), Lysine exporter LysO No TMH predictionsIntegral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN250.234TMH05.36895-89No6-23i35-55o61-83i104-129o135-155i167-188o208-228i249-267o279-297iCytoplasmicMembrane10
MACA_ECOLIP75830
macA

ybjY

ybjYb0878 JW0862 integral IM protein (SEC in IM), Macrolide export MacA Integral Inner MembraneThe crystal structure of MacA has been determined at 3.0A resolution. The inner membrane transporter MacB requires the outer membrane factor TolC and the periplasmic adaptor protein MacA to form a functional tripartite complex. Electron microscopic indicates that the MacA hexamer interacts with TolCIn a tip-to-tip manner. PMID: 11544226 PMID: 17214741PMID: 19254725 PMID: 21325274 PMID: 21890895 PMID: 11544226 PMID: 17214741Integral Inner MembraneBN/ACell inner membrane Membrane anchoredSECyesyesN320.134SpI313.90027-11Ni12-29oCytoplasmicMembrane745
MACB_ECOLIP75831
macB

ybjZ

ybjZb0879 JW0863 integral IM protein (SEC in IM), Macrolide export ATP-binding/permease MacB Integral Inner Membrane The crystal structure of MacA has been determined at 3.0A resolution. The inner membrane transporter MacB requires the outer membrane factor TolC and the periplasmic adaptor protein MacA to form a functional tripartite complex. Electron microscopic indicates that the MacA hexamer interacts with TolCIn a tip-to-tip manner.PMID: 19254725 PMID: 21325274 PMID: 11544226 PMID: 17214741Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN340.136CYT0-0.200913-44Ni273-293o523-548i572-602o608-631iCytoplasmicMembrane1017
YCAM_ECOLIP75835
ycaM
b0899 JW5119 integral IM protein (SEC in IM), transporter YcaMIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN350.133TMH012.317-1212Ni12-30o42-63i84-102o126-146i153-176o196-218i239-261o293-312i344-364o384-402i414-435o447-470iCytoplasmicMembrane10
SSUC_ECOLIP75851
ssuC

ycbM

ycbMb0934 JW5121 integral IM protein (SEC in IM), Putative aliphatic sulfonates transport permease SsuC Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN240.119TMH120077Ni12-34o69-92i104-122o128-147i168-185o191-211i223-245oCytoplasmicMembrane106
YCCS_ECOLIP75870
yccS
b0960 JW5128 integral IM protein (SEC in IM), YccSIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN360.115TMH06.42867-912Ni15-34o40-57i64-81o87-105i112-133o139-161i389-410o416-433i440-459o465-482i487-503o509-531iCytoplasmicMembrane10
GFCA_ECOLIP75885
gfcA

ymcD

ymcDb0987 JW5133 integral IM protein (SEC in IM), Threonine-rich GfcA Integral Inner Membrane When the protein is over-expressed protein is located on the Inner Membrane.PMID: 15919996Integral Inner MembraneBout/outIM (predicted)Cell inner membrane; Single-pass membrane protein Membrane anchoredSRPSECnoyesY220.858SpI2131.9353-20Yn5-16c21/22oCytoplasmicMembrane10113
RUTG_ECOLIP75892
rutG

ycdG

ycdGb1006 JW5137 integral IM protein (SEC in IM), Putative pyrimidine permease RutG Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN430.115CYT0-0.200913-1112Ni33-54o60-76i83-103o109-129i141-161o173-190i197-219o239-261i281-299o319-338i350-373o385-418iCytoplasmicMembrane10
EFEU_ECOLIP75901
efeU

ycdN

ycdNb4490 JW5141/JW1002 b1016/b1017integral IM protein (SEC in IM), Putative inactive ferrous iron permease EfeU Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane CytoplasmicSRPSECpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoN160.112CYT0-0.200913-67No6-26i38-58o70-90i117-142o148-171i183-203o248-265iCytoplasmicMembrane10
PGAC_ECOLIP75905
pgaC

ycdQ

ycdQb1022 JW1007 integral IM protein (SEC in IM), Poly-beta-1,6-N-acetyl-D-glucosamine synthase PgaCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN230.19TMH017.09-54Yn6-17c22/23o32-54i323-345o365-383i395-417oCytoplasmicMembrane1017
DGCT_ECOLIP75908
dgcT

ycdT

ycdTb1025 JW5143 integral IM protein (SEC in IM), Probable diguanylate cyclase DgcTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN310.126TMH010.4982-88Ni12-29o41-67i79-99o114-131i151-169o189-213i220-241o261-278iCytoplasmicMembrane10
YCDU_ECOLIP75910
ycdU
b1029 JW1015 integral IM protein (SEC in IM), YcdUIntegral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN360.12TMH07.11263-88Ni16-32o44-68i89-114o120-141i162-182o202-222i255-277o289-309iCytoplasmicMembrane10
OPGC_ECOLIP75920
mdoC

opgC ymdD

opgC ymdDb1047 JW1034 integral IM protein (SEC in IM), Glucans biosynthesis C MdoCIntegral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN420.12TMH012.3178-1010Ni17-38o58-80i92-113o133-157i177-201o213-234i246-264o276-295i307-330o336-356iCytoplasmicMembrane10
C56I_ECOLIP75925
yceJ
b1057 JW1044 integral IM protein (SEC in IM), Cytochrome b561 homolog 2 YceJIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN310.121TMH013.644-44Ni12-35o55-72i92-111o144-164iCytoplasmicMembrane1010
YCFT_ECOLIP75955
ycfT
b1115 JW1101 integral IM protein (SEC in IM), YcfTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN330.109TMH011.9971-88Ni12-32o52-70i90-113o133-156i163-183o195-212i224-256o310-331iCytoplasmicMembrane10
LOLE_ECOLIP75958
lolE

ycfW

ycfWb1118 JW1104 integral IM protein (SEC in IM), Lipoprotein-releasing system TM protein LolEIntegral Inner Membrane PMID: 17498646 PMID: 15276320 PMID: 10783239Integral Inner MembraneBBpolyin/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECnoyesN360.113TMH06.76692-44Ni21-48o270-293i314-341o380-399iCytoplasmicMembrane1020
YCFZ_ECOLIP75961
ycfZ
b1121 JW1107 integral IM protein (SEC in IM), YcfZIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN190.268SpI207.80323-43Yn4-14c19/20o183-201i208-230o242-259iCytoplasmicMembrane10
PDEG_ECOLIP75995
pdeG

ycgG

ycgGb1168 JW5174 integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeGIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSECnoyesN330.194CYT0-0.200913-22No6-28i221-239oCytoplasmicMembrane7
NHAP2_ECOLIP76007
cvrA

nhaP2 ycgO

nhaP2 ycgOb1191 JW5184 integral IM protein (SEC in IM), K(+)/H(+) antiporter NhaP2 CvrAIntegral Inner MembraneBBpolyout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN460.165TMH09.70846-1113No6-23i30-47o59-76i88-113o119-141i162-179o191-210i217-237o243-261i273-292o298-323i335-357o363-381iCytoplasmicMembrane10
PUUP_ECOLIP76037
puuP

ycjJ

ycjJb1296 JW1289 integral IM protein (SEC in IM), Putrescine importer PuuP Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN430.116TMH02.35137-1212Ni24-47o59-77i98-120o132-150i162-182o202-221i241-264o291-319i340-359o365-386i398-417o423-442iCytoplasmicMembrane10
YNBB_ECOLIP76091
ynbB
b1409 JW1406 integral IM protein (SEC in IM), YnbBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/outIM (predicted), Detected in IM FractionCell membrane Integral Membrane ProteinSRPSECnoyesN600.122TMH08.47225-97Yn6-16c21/22o37-54i61-83o95-119i131-154o166-187i208-227o233-253iCytoplasmicMembrane10
YNBD_ECOLIP76093
ynbD
b1411 JW1408 integral IM protein (SEC in IM), YnbDIntegral Inner MembraneBBpolyout/outIM (predicted)Cell membrane Integral Membrane ProteinSRPSECnoyesN240.123TMH013.3648-88Yn4-15c33/34o49-72i84-105o125-141i153-170o176-193i213-236o242-261i273-292oCytoplasmicMembrane10
YDCO_ECOLIP76103
ydcO
b1433 JW5229 integral IM protein (SEC in IM), YdcOIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN270.198TMH015.9189-1012Yn10-20c25/26o41-63i70-88o94-114i119-138o144-161i168-187o207-224i236-254o260-276i288-313o319-337i349-382oCytoplasmicMembrane10
DGCF_ECOLIP76147
dgcF

yneF

yneFb1522 JW5825 integral IM protein (SEC in IM), Probable diguanylate cyclase DgcFIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECpseudogene (Ochman & Davalos, 2006)nonoN340.118TMH09.08181-44No12-29i41-68o80-102i114-135oCytoplasmicMembrane1031
YNFH_ECOLIP76173
ynfH
b1590 JW5261 integral IM protein (SEC in IM), Anaerobic dimethyl sulfoxide reductase chain YnfHIntegral Inner Membrane The physiological substrate and relevance of the YnfFGH S- and N-oxide reductase is unknown. DmsC paralog. So far, hydroxy pyridine N-oxide is the best substrate for YnfFGH. ynfFGH are expressed anaerobically. YnfH can function with DmsAB, replacing DMSC a The ynfEFGHI operon is a paralogue of the Escherichia coli dmsABC operon. ynfE and ynfF are paralogues of dmsA. ynfG and ynfH are paralogues of dmsB and dmsC, respectively. PMID: 14522592PMID: 15919996 PMID: 14522592Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN340.15TMH013.2137-88No12-34i46-67o87-104i116-138o150-169i181-204o224-243i250-271oCytoplasmicMembrane10
CLCB_ECOLIP76175
clcB

mriT ynfJ

mriT ynfJb1592 JW5263 nucleoid & integral IM protein (SEC in IM), Voltage-gated ClC-type chloride channel ClcB Integral Inner Membrane, NucleoidPMID: 23138451 PMID: 15919996Integral Inner Membrane, NucleoidB, Nout/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN210.254TMH010.4168-109Yn5-16c21/22o54-71i144-162o174-200i221-241o261-282i294-313o319-338i350-372o384-404iCytoplasmicMembrane1039
RSXD_ECOLIP76182
rsxD

rnfD ydgO

rnfD ydgOb1630 JW1622 integral IM protein (SEC in IM), Ion-translocating oxidoreductase complex subunit D RsxDIntegral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN340.191TMH05.44392-1010Ni20-38o44-62i69-89o95-113i125-143o210-235i242-262o268-287i299-318o324-342iCytoplasmicMembrane10
YDHJ_ECOLIP76185
ydhJ
b1644 JW1636 integral IM protein (SEC in IM), YdhJIntegral Inner MembraneBBinout/inN/AMembrane Membrane anchoredSRPSECyesyesN690.119TMH04.39451-11No6-26iCytoplasmicMembrane926
YDHK_ECOLIP76186
ydhK
b1645 JW1637 integral IM protein (SEC in IM), transporter YdhKEchoLOCATION Signal peptide may be membrane anchored or cleaved and the protein therefore exported (signalP score near threshold)Integral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN200.119TMH04.68512-1012Ni21-41o47-65i72-88o94-112i119-137o149-170i359-379o385-404i411-431o437-454i461-481o493-510iCytoplasmicMembrane10
YDIM_ECOLIP76197
ydiM
b1690 JW1680 integral IM protein (SEC in IM), transport YdiMIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN420.151TMH09.7669-1212Ni12-30o42-62i74-90o96-112i133-156o162-183i204-227o247-268i275-292o298-325i337-359o365-385iCytoplasmicMembrane10
YDIN_ECOLIP76198
ydiN
b1691 JW5274 integral IM protein (SEC in IM), transport YdiNIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN340.235TMH011.6576-1212Ni12-30o50-72i79-97o103-126i133-152o164-185i210-235o255-273i280-301o307-329i341-363o369-390iCytoplasmicMembrane10
YDJX_ECOLIP76219
ydjX
b1750 JW1739 integral IM protein (SEC in IM), of TVP38/TMEM64 family and DedA family, YdjXIntegral Inner Membrane Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF.PMID: 15919996 PMID: 23086209Integral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane ProteinSRPSECyesyesN240.175TMH013.2473-56Ni7-30o50-76i83-104o124-146i158-180o192-214iCytoplasmicMembrane10
YDJZ_ECOLIP76221
ydjZ
b1752 JW1741 integral IM protein (SEC in IM), of TVP38/TMEM64 family and DedA family, YdjZ Integral Inner Membrane Member of the DedA family. DedA family proteins may play a more general role in membrane protein function or quality control and in maintenance of the PMF.PMID: 15919996 PMID: 23086209Integral Inner MembraneBBpolyout/inIM (predicted), Detected in IM FractionCell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN460.23TMH023.0428-55Yn16-27c45/46o55-73i80-97o103-121i177-196o202-223iCytoplasmicMembrane10
YNJC_ECOLIP76224
ynjC
b1755 JW5285 integral IM protein (SEC in IM), ABC transporter permease YnjCIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN470.204TMH014.426-1212Ni7-33o53-80i92-111o131-156i177-202o239-260i281-303o315-337i346-370o376-395i428-449o482-503iCytoplasmicMembrane10
YNJI_ECOLIP76228
ynjI
b1762 JW5288 integral IM protein (SEC in IM), YnjIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN580.169CYT0-0.200913-22Ni42-64o70-91iCytoplasmicMembrane104
YDJK_ECOLIP76230
ydjK
b1775 JW5290 integral IM protein (SEC in IM), Putative metabolite transport YdjK Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN430.144TMH03.8405-1212Ni25-49o61-82i89-107o113-137i158-176o182-202i266-287o302-323i330-347o353-375i396-416o422-441iCytoplasmicMembrane10
CDGI_ECOLIP76236
cdgI

yeaI

yeaIb1785 JW1774 integral IM protein (SEC in IM), Probable diguanylate cyclase CdgIIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN560.137CYT0-0.200913-88Ni58-76o88-110i122-143o163-182i194-215o235-257i269-287o293-318iCytoplasmicMembrane10
DGCJ_ECOLIP76237
dgcJ

yeaJ

yeaJb1786 JW5291 integral IM protein (SEC in IM), Probable diguanylate cyclase DgcJIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBinoutout/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN370.176SpI301.61892-21Yn11-26c31/32o305-327iCytoplasmicMembrane915
NIMT_ECOLIP76242
nimT

yeaN

yeaNb1791 JW1780 integral IM protein (SEC in IM), 2-nitroimidazole transporter NimTIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN340.135TMH04.63339-1212Ni12-37o49-70i82-98o104-126i138-160o166-185i212-239o251-270i279-299o305-323i335-355o367-387iCytoplasmicMembrane10
LEUE_ECOLIP76249
leuE

yeaS

yeaSb1798 JW1787 integral IM protein (SEC in IM), Leucine efflux protein LeuEIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell membrane Integral Membrane Protein (Experimental)SRPSECyesyesN470.141TMH012.792-66No12-32i44-69o81-99i120-142o154-179i191-209oCytoplasmicMembrane10
PDED_ECOLIP76261
pdeD

adrB yoaD

adrB yoaDb1815 JW1804 integral IM protein (SEC in IM), Probable cyclic di-GMP phosphodiesterase PdeDIntegral Inner MembraneBBinoutin/outIM (predicted)Cell membrane Membrane anchoredSRPSECnoyesN290.12SpI351.97681-11Yn17-27c32/33o245-265iCytoplasmicMembrane713
MNTP_ECOLIP76264
mntP

yebN

yebNb1821 JW5830 integral IM protein (SEC in IM), Probable manganese efflux pump MntP Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesY200.786SpI198.81356-54Yn3-11c19/20o68-86i106-127o133-154i166-186oCytoplasmicMembrane10
YEBQ_ECOLIP76269
yebQ
b1828 JW5299 integral IM protein (SEC in IM), transporter YebQIntegral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN490.145TMH03.99006-1214Ni15-34o54-74i86-107o113-133i145-167o173-191i203-225o231-249i269-295o307-328i335-357o363-379i400-420o432-451iCytoplasmicMembrane10
YEBT_ECOLIP76272
yebT
b1834 JW1823 integral IM protein (SEC in IM), Intertransport YebT Integral Inner MembraneBBoutin/outIM (predicted), Detected in IM FractionCell inner membrane Membrane anchoredSRPSECyesyesN470.12TMH04.96376-11Ni21-39oUnknown230
YEBZ_ECOLIP76278
yebZ
b1840 JW1829 integral IM protein (SEC in IM), YebZIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyout/outIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane Protein (Experimental)SRPSECyesyesN310.14TMH012.9484-88No6-29i50-73o93-111i118-138o150-171i192-215o227-248i269-287oCytoplasmicMembrane10
FLHA_ECOLIP76298
flhA
b1879 JW1868 integral IM protein (SEC in IM), biosynthesis FlhAIntegral Inner Membrane Part of FlgN-FlgK-FliJ-FlhA complex.PMID: 22233518 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN240.137TMH010.1028-78Ni21-40o46-65i77-97o117-140i209-231o251-273i285-305o311-327iCytoplasmicMembrane1014
FLHB_ECOLIP76299
flhB

yecQ

yecQb1880 JW1869 integral IM protein (SEC in IM), biosynthetic FlhBIntegral Inner Membrane Regulates ordered export of flagellar components via autocleavage mechanism.PMID: 16246842 PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECyesyesN540.142CYT0-0.200913-44Ni35-53o88-115i145-168o188-213iCytoplasmicMembrane10
DGCQ_ECOLIP76330
dgcQ

yedQ

yedQb1956 JW5832 integral IM protein (SEC in IM), Probable diguanylate cyclase DgcQIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECnoyesN440.109TMH00.725864-22Ni21-42o358-380iCytoplasmic912
YEDV_ECOLIP76339
yedV
b1968 JW1951 integral IM protein (SEC in IM), Sensor histidine kinase YedVIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBinoutout/inIM (predicted)Cell inner membrane Membrane anchoredSRPSECyesyesN240.26TMH07.43701-21Yn10-18c23/24o159-180iCytoplasmicMembrane1012
MSRQ_ECOLIP76343
msrQ

yedZ

yedZb1972 JW1955 integral IM protein (SEC in IM), Protein-methionine-sulfoxide reductase heme-binding subunit MsrQ Integral Inner Membrane Is attached to the inner membrane when interacting with the YedZ subunit.PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane protein Integral Membrane ProteinSRPSECyesyesN300.146TMH06.8144-66Ni9-30o50-68i80-98o118-138i150-167o173-191iCytoplasmicMembrane10
C56H_ECOLIP76345
yodB
b1974 JW5323 integral IM protein (SEC in IM), Cytochrome b561 homolog 1 YodBIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane; Multi-pass membrane proteinIntegral Membrane ProteinSRPSECnoyesN250.146TMH08.67869-44Ni9-26o46-63i84-108o144-162iCytoplasmicMembrane1015
SHIA_ECOLIP76350
shiA

yeeM

yeeMb1981 JW1962 integral IM protein (SEC in IM), Shikimate transporter ShiAIntegral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN300.125TMH00.821024-1212Ni25-49o61-84i96-114o120-139i160-184o196-215i256-276o288-310i317-336o342-363i383-408o414-432iCytoplasmicMembrane103
YEEO_ECOLIP76352
yeeO
b1985 JW1965 integral IM protein (SEC in IM), Probable FMN/FAD exporter YeeO Integral Inner Membrane PMID: 15919996Integral Inner MembraneBBpolyin/inIM (predicted)Cell inner membrane Integral Membrane ProteinSRPSECyesyesN300.152CYT0-0.200913-1112Ni45-71o83-105i117-140o160-180i192-216o222-247i268-289o309-332i352-375o387