entryaccgenealt_geneolnprotein_namecm_locacm_notescm_refssuboci_fullsublocisubloci_iimnterm_ctermbernselsubloci_uniprotsubloci_echoLorganelletarget_chaperoning11st_sstarget_chaperoning22nd_sspseudocommon_corebasic_proteomesignalp_sp_existsignalp_possignalp_cmaxlipop_predlipop_cleavagelipop_scorelipop_ruletmhmmphobius_tmsphobius_sp_existphobius_predictionpsortb_locapsortb_scoresolubility
YMGJ_ECOLIA5A612
ymgJ
b4594 Uncharacterized membrane protein ypdKWeak signal peptide prediction. Function Unkown.PeriplasmicGIM (predicted)-SECnoyesN240.144CYT0-0.200913-00Yn6-17c22/23oUnknown2
YJBT_ECOLIA5A628
yjbT
b4620 Uncharacterized protein yjbTBelongs to the yjbT family.PeriplasmicGN/A-SECnoyesY300.744SpI2915.6556-10Yn15-25c29/30oPeriplasmic9.84
RZOQ_ECOLIC1P601
rzoQ
b4689 JW1545.1 Uncharacterized J domain-containing protein djlCInner Membrane LipoproteinEN/ACell membrane | Lipid-anchor-SECLOLnoyesN290.129SpII2211.4311Pos+2=V00Yn9-20c25/26oUnknown2
YPDI_ECOLIO32528
ypdI
b2376 JW2373 Uncharacterized lipoprotein ypdIOuter Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane LipoproteinSECLOLnoyesY240.415SpII1812.5879Pos+2=N10Yn5-16c23/24oUnknown222.88
YFJS_ECOLIO52982
yfjS
b2636 JW5921 Uncharacterized lipoprotein yfjSInner Membrane LipoproteinEN/ACell membrane | Lipid-anchorInner membrane lipoproteinSECLOLProphage Integrase (EcoGene)nonoY210.479SpII2018.7233Pos+2=D00Yn6-17c21/22oUnknown2.5
PPB_ECOLIP00634
phoA
b0383 JW0374 Alkaline phosphatase (APase) (EC 3.1.3.1)Periplasm Periplasmic Substrate of periplasmic disulfide oxidoreductases DsbA. Alkaline phosphatase (EC 3.1.3.1; APase) of E.coli is a periplasmic enzyme. PMID: 3533724 Identified DsbA substrate PMID: 19953543 PMID: 7022451 An amber mutation in the secA gene of Escherichia coli causes a pleiotropic decrease in the synthesis of secreted proteins. PMID: 3009404 Disulfide bridges (190 200;308 358) Disulfide bridges (190 200;308 358) Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 3533724 PMID: 19953543 PMID: 7022451 PMID: 3009404 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAnoyesY220.408SpI213.05238-00Yn5-16c21/22oPeriplasmic1078.02
ASPG2_ECOLIP00805
ansB
b2957 JW2924 L-asparaginase 2 (EC 3.5.1.1) (L-asparaginase II) (L-ASNase II) (L-asparagine amidohydrolase II) (Colaspase)Periplasmic Periplasmic Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 Disulfide bridge (99 127) PMID: 8434007 Disulfide bond-containing protein PMID: 25664544PMID: 387570 PMID: 2407723 PMID: 25403562 PMID: 8434007 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY230.82SpI2219.7315-10Yn7-17c22/23oPeriplasmic1049.18
YGDB_ECOLIP08370
ygdB
b2824 JW5450 Uncharacterized protein ygdBPeriplasmicGN/APeriplasmicSECyesyesN270.147SpI267.55205-10Yn10-23c35/36oUnknown2.57
YCCT_ECOLIP0A8X4
yccT
b0964 JW0947 UPF0319 protein yccTPeriplasmicGN/APeriplasmicSECyesyesY210.531SpI206.4525-00Yn3-14c20/21oUnknown2.560.35
YOBA_ECOLIP0AA57
yobA
b1841 JW1830 Protein yobAPeriplasmicGN/APeriplasmPeriplasmicSECyesyesY270.511SpI2613.4937-00Yn11-21c26/27oPeriplasmic9.76
AMPC_ECOLIP00811
ampC

ampA

ampAb4150 JW4111 Beta-lactamase (EC 3.5.2.6) (Cephalosporinase)PeriplasmicPMID: 6795623PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY200.854SpI1917.1519-00Yn4-15c19/20oPeriplasmic1026.22
ARAF_ECOLIP02924
araF
b1901 JW1889 L-arabinose-binding periplasmic protein (ABP)PeriplasmicPMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY240.816SpI2320.0244-00Yn7-18c23/24oPeriplasmic1086.5
RBSB_ECOLIP02925
rbsB

prlB rbsP

prlB rbsPb3751 JW3730 D-ribose-binding periplasmic proteinPeriplasmic Periplasmic Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 15911532 PMID: 19953543 PMID: 9298646PeriplasmicGSoluble IM FractionPeriplasmPeriplasmic (Experimental)SECSKPnoyesY260.839SpI2522.7093-00Yn6-17c25/26oPeriplasmic1093.52
TOLC_ECOLIP02930
tolC

mtcB mukA refI

mtcB mukA refIb3035 JW5503 Outer membrane protein tolCOuter membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein. Outer membrane protein (experimental). Outer Membrane Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel proteinPart of MdtABC-TolC multidrug efflux transport system = [(TolC)3][MdtC][MdtB][MdtA]. Also part of MacAB-TolC macrolide efflux transport system = [(TolC)3][MacB]2[MacA]. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000).The crystal structure of MacA has been determined at 3.0A resolution. The inner membrane transporter MacB requires the outer membrane factor TolC and the periplasmic adaptor protein MacA to form a functional tripartite complex. Electron microscopic indicates that the MacA hexamer interacts with TolCIn a tip-to-tip manner. Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 12107133 PMID: 19254725 PMID: 21325274 PMID: 16372265 PMID: 16352602 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 10879525 PMID: 15228545 PMID: 16079137 PMID: 21778229 PMID: 20932056 PMID: 10806384 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECBSECSKPBAMyesyesY230.712SpI2210.2716-00Yn4-14c22/23oOuterMembrane1015.92
YACC_ECOLIP0AA95
yacC
b0122 JW0118 Uncharacterized protein yacCPeriplasmicGN/APeriplasmicSECyesyesY230.239SpI2410.6167-00Yn7-17c22/23oUnknown2.521.8
MATB_ECOLIP0AAA3
matB

yagZ

yagZb0293 JW0287 Fimbrillin matB homologPeriplasmicPutative chaperone–usher fimbrial operon yag (class α); Fimbrial Subunit (yagZ). PMID: 16522795PMID: 20345943 PMID: 16522795PeriplasmicGN/APeriplasmic (Experimental)fimbriaeSECnoyesY230.863SpI2225.6343-00Yn5-15c22/23oUnknown2.534.62
OMPF_ECOLIP02931
ompF

cmlB coa cry tolF

cmlB coa cry tolFb0929 JW0912 Outer membrane protein F (Outer membrane protein 1A) (Outer membrane protein B) (Outer membrane protein IA) (Porin OmpF)Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane (experimental) Outer Membrane Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel proteinSubstrate of periplasmic peptidyl prolyl cis–trans isomerase SurA. Potential pubstrate of periplasmic chaperones Skp. Outer membrane proteins OmpF, OmpC, and OmpX as central to the YebF export mechanism. Trigger factor-sensitive aggregation. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 9298646PMID: 8626309 PMID: 17908933 PMID: 19343722 PMID: 22658749 PMID: 19737520 PMID: 12488465 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 1380671 PMID: 11266632 PMID: 16079137 PMID: 20932056 PMID: 10806384 PMID: 21541338 PMID: 19953543 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)TFSECSKP,SURABAMyesyesY230.883SpI2219.9098-00Yn6-17c22/23oOuterMembrane1018.18
PHOE_ECOLIP02932
phoE

ompE

ompEb0241 JW0231 Outer membrane pore protein EOuter membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel proteinPMID: 1380671 PMID: 11266632 PMID: 20932056 PMID: 216015Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECBAMyesyesY220.841SpI2121.3546-00Yn5-16c21/22oOuterMembrane102.7
LAMB_ECOLIP02943
lamB

malB

malBb4036 JW3996 Maltoporin (Lambda receptor protein) (Maltose-inducible porin)Outer membrane protein. Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel protein Potential pubstrate of periplasmic chaperones Skp. Substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy 2000). Experimentally verified trimeric beta-barrel. N-terminal region is in periplasm. Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 346375 Disulfide bridges between 47 and 63 PMID: 1988451 Disulfide bond-containing protein PMID: 25664544PMID: 16372265 PMID: 8626309 PMCID: PMC1993877 PMID: 19343722 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 7824948 PMID: 11266632 PMID: 16079137 PMID: 20932056 PMID: 10806384 PMID: 19953543 PMID: 19953543 PMID: 346375 PMID: 1988451 PMID: 25664544Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECSKP,SURA,DEGPBAMyesyesY260.795SpI2520.7922-00Yn8-18c25/26oOuterMembrane1054.55
ZRAP_ECOLIP0AAA9
zraP

yjaI zra

yjaI zrab4002 JW5546 Zinc resistance-associated proteinPeriplasmic Heavy-metal resistance protein (IPR025961) PMID: 9694902 PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY270.74SpI2628.6968-10Yn7-18c26/27oPeriplasmic10
YKGJ_ECOLIP0AAL9
ykgJ
b0288 JW0282 Uncharacterized protein ykgJ PeriplasmicGN/APeriplasmicSECnoyesN270.286SpI244.7292-00="0"iUnknown233.44
YBAV_ECOLIP0AAR8
ybaV
b0442 JW0432 Uncharacterized protein ybaVPeriplasmicGN/APeriplasmicSECyesyesY260.681SpI2523.157-00Yn7-17c25/26oCytoplasmicMembrane9.97
MALM_ECOLIP03841
malM

molA

molAb4037 JW3997 Maltose operon periplasmic proteinPeriplasmicPMID: 2434655PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY270.606SpI2624.5925-00Yn7-18c26/27oPeriplasmic10
FIMA1_ECOLIP04128
fimA

pilA

pilAb4314 JW4277 Type-1 fimbrial protein, A chain (Type-1A pilin)Cell surface appendage Fim operon (class γ1); Fimbrial Subunit. Experimentally verified signal peptide PMID: 2858471 Disulfide bridge (44 84) Disulfide bond-containing protein PMID: 25664544PMID: 20345943 PMID: 6147250 PMID: 2858471 PMID: 25664544Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbriumCell surface appendage (Experimental)fimbriaeSECCUyesyesY240.78SpI2325.7568-10Yn5-16c23/24oExtracellular10
LIVK_ECOLIP04816
livK
b3458 JW3423 Leucine-specific-binding protein (L-BP) (LS-BP) Periplasmic Identified DsbA substrate PMID: 19953543 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bridge (76 101) Disulfide bridge (42 47) PMID: 8061609 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 9298646 PMID: 22030350 PMID: 8061609 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY240.817SpI2317.7516-00Yn7-18c23/24oPeriplasmic1078.71
NLPA_ECOLIP04846
nlpA
b3661 JW3635 Lipoprotein 28Lipoprotein (experimental). Proven signal peptidase II substrate.PMID: 15174130Inner Membrane LipoproteinESoluble IM FractionCell inner membrane | Lipid-anchorInner membrane lipoproteinSECLOLyesyesY230.355SpII2321.7987Pos+2=D00Yn10-21c26/27oCytoplasmicMembrane1077.23
PTRA_ECOLIP05458
ptrA

ptr

ptrb2821 JW2789 Protease 3 (EC 3.4.24.55) (Pitrilysin) (Protease III) (Protease pi)PeriplasmicPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 15502359PMID: 18498364 PMID: 15502359PeriplasmicGN/APeriplasmPeriplasmic(experimental)SECSURAyesyesY240.815SpI2313.0719-00Yn9-18c23/24oPeriplasmic1066.05
YBGS_ECOLIP0AAV6
ybgS
b0753 JW0736 Uncharacterized protein ybgS Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY250.845SpI2432.7676-00Yn6-17c24/25oPeriplasmic9.84
YBIJ_ECOLIP0AAX3
ybiJ
b0802 JW0787 Uncharacterized protein ybiJPeriplasmicGN/APeriplasmPeriplasmicSECyesyesY230.811SpI2221.8351-10Yn7-18c22/23oUnknown2.5
FEPA_ECOLIP05825
fepA

fep feuB

fep feuBb0584 JW5086 Ferrienterobactin receptor (Enterobactin outer-membrane receptor) Outer membrane. Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel protein Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 10529396 Disulfide bond-containing protein PMID: 25664544PMID: 12624733 PMID: 11266632 PMID: 9886293 PMID: 20932056 PMID: 10806384 PMID: 19953543 PMID: 10529396 PMID: 25664544Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECSKPBAMyesyesY230.836SpI2211.5401-00Yn7-17c22/23oOuterMembrane1011.34
BTUB_ECOLIP06129
btuB

bfe cer dcrC

bfe cer dcrCb3966 JW3938 Uncharacterized protein yhcFCytoplasmic. Outer membrane protein (experimental). Outer membrane. Outer Membrane Outer Membrane Outer Membrane Outer membrane protein (experimental). Outer Membrane ss-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 12652322 PMID: 2982793 PMID: 2687240 PMID: 12595710 PMID: 10806384 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECSKPBAMnoyesY210.828SpI2021.8455-00Yn5-16c20/21oOuterMembrane10
CDH_ECOLIP06282
cdh
b3918 JW3889 CDP-diacylglycerol pyrophosphatase (EC 3.6.1.26) (CDP-diacylglycerol phosphatidylhydrolase) (CDP-diglyceride hydrolase)PeriplasmicGSoluble IM FractionCell inner membrane | Single-pass membrane proteinMembrane anchoredSECyesyesN190.264SpI197.43557-10Yn4-14c19/20oCytoplasmicMembrane1055.48
MCBA_ECOLIP0AAX6
mcbA

ybiM

ybiMb0806 JW5106 Uncharacterized protein mcbA (MqsR-controlled colanic acid and biofilm protein A)PeriplasmicGN/APeriplasmPeriplasmicSECyesyesY230.869SpI2218.838-10Yn4-14c22/23oUnknown2.5
YBJH_ECOLIP0AAY4
ybjH
b0843 JW0827 Uncharacterized protein ybjHPeriplasmicGN/APeriplasmicSECyesyesY230.874SpI2225.9172-10Yn6-17c22/23oUnknown2.510.11
YCEK_ECOLIP0AB31
yceK
b1050 JW5151 Uncharacterized protein yceKLipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLnoyesN310.129SpII155.35698Pos+2=G00Yn3-13c18/19oUnknown2
BHSA_ECOLIP0AB40
bhsA

comC ycfR

comC ycfRb1112 JW1098 Multiple stress resistance protein BhsAPeripheral outer membrane protein.By membrane fractionation, ComC was shown to be localized in the outer membrane.PMID: 22089859Peripheral outer membrane protein facing the periplasmF3N/APeriplasmPeriplasmicSECyesyesY230.773SpI2221.6297-00Yn6-14c22/23oUnknown2.570.66
FHUA_ECOLIP06971
fhuA

tonA

tonAb0150 JW0146 Uncharacterized protein yohNOuter membrane protein (experimental). Outer membrane protein (experimental). Outer membrane. Outer membrane protein (experimental). Outer Membrane ss-barrel protein SecB substrate; Substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 3079747 Disulfide bridge (351 362;725 731) Disulfide bond-containing protein PMID: 25664544PMID: 16352602 PMID: 19343722 PMID: 15911532 PMID: 12624733 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 9856937 PMID: 10806384 PMID: 19953543 PMID: 19953543 PMID: 3079747 PMID: 25664544Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECBSECSURA,SKPBAMyesyesY340.805SpI3320.4987-00Yn16-24c33/34oOuterMembrane107.42
OMPC_ECOLIP06996
ompC

meoA par

meoA parb2215 JW2203 Bacteriophage N4 adsorption protein AOuter membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel proteinOuter membrane protein related to resistance to ampicillin and tetracycline; Potential pubstrate of periplasmic chaperones Skp. Outer membrane proteins OmpF, OmpC, and OmpX as central to the YebF export mechanism. Trigger factor-sensitive aggregation. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 16372265 PMID: 17908933 PMID: 22658749 PMID: 19737520 PMID: 12488465 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 10806384 PMID: 21541338 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)TFSECSKPBAMyesyesY220.884SpI2121.1188-00Yn5-16c21/22oOuterMembrane106.56
YFIB_ECOLIP07021
yfiB
b2605 JW2586 Putative lipoprotein yfiBOuter membrane Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN250.134SpII1818.8761Pos+2=Q00Yn5-16c20/21oOuterMembrane9.9274.52
YMGD_ECOLIP0AB46
ymgD
b1171 JW5177 Uncharacterized protein ymgD Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECnoyesY200.656SpI1914.7848-00Yn4-14c19/20oUnknown2.586.15
HOKC_ECOLIP0ACG4
hokC

gef

gefb4412 JW5002 b0018.1Uncharacterized protein yqeIInner membrane.Potentially toxic protein.PMID: 19121005 PMID: 21890895PeriplasmicGN/ACell inner membrane | Single-pass type II membrane proteinPeriplasmicSECnoyesN220.361SpI215.3199-10Yn8-16c21/22oPeriplasmic9.9732.43
HOKD_ECOLIP0ACG6
hokD

relF

relFb1562 JW1554 Protein hokD (Protein relF)PeriplasmicGN/ACell membrane | Single-pass membrane proteinPeriplasmicSECProphage Integrase (EcoGene)nonoN230.157SpI222.62207-10Yn8-19c26/27oPeriplasmic9.96
YDBJ_ECOLIP0ACW2
ydbJ
b4529 JW5215 Uncharacterized protein ydbJOuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLnoyesY250.374SpII1617.2226Pos+2=S00Yn3-14c19/20oUnknown2.524.24
USHA_ECOLIP07024
ushA
b0480 JW0469 Protein ushA [Includes: UDP-sugar hydrolase (EC 3.6.1.45) (UDP-sugar diphosphatase) (UDP-sugar pyrophosphatase); 5'-nucleotidase (5'-NT) (EC 3.1.3.5)]Periplasmic Disulfide bridge (258 275) Disulfide bond-containing protein PMID: 25664544PMID: 9298646 PMID: 25664544PeriplasmicGSoluble IM FractionPeriplasmPeriplasmic (Experimental)SECnoyesY260.748SpI2511.3752-00Yn7-18c25/26oPeriplasmic1077.35
PPA_ECOLIP07102
appA
b0980 JW0963 Periplasmic AppA protein [Includes: Phosphoanhydride phosphohydrolase (EC 3.1.3.2) (pH 2.5 acid phosphatase) (AP); 4-phytase (EC 3.1.3.26)] Periplasmic Identified DsbC substrate PMID: 19953543 PMID: 8387749 Disulfide bridge (99 130;155 430;200 210;404 413) Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 8387749 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBCyesyesY230.793SpI2213.6965-00Yn3-13c22/23oPeriplasmic1066.26
FIMF_ECOLIP08189
fimF
b4318 JW4281 Protein fimFCell surface appendage Fim operon (class γ1); Fimbrial Subunit. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. PMID: 15372038 Disulfide bridge (38 78) Disulfide bond-containing protein PMID: 25664544PMID: 19820722 PMID: 2890081 PMID: 20345943 PMID: 15372038 PMID: 25664544Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbriumCell surface appendage (Experimental)fimbriaeSECCUnoyesY230.871SpI2217.2366-00Yn6-17c22/23oExtracellular9.72
FIMG_ECOLIP08190
fimG
b4319 JW4282 Protein fimGCell surface appendage Fim operon (class γ1); Fimbrial Subunit. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. PMID: 15372038 Disulfide bridge (39 77) Disulfide bond-containing protein PMID: 25664544PMID: 19820722 PMID: 2890081 PMID: 20345943 PMID: 15372038 PMID: 25664544Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbriumCell surface appendage (Experimental)fimbriaeSECCUnoyesY240.773SpI2318.1281-10Yn7-18c23/24oExtracellular9.6573.47
YDCA_ECOLIP0ACW4
ydcA
b1419 JW1416 Uncharacterized protein ydcA Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECnoyesY210.761SpI2012.9463-00Yn4-15c20/21oUnknown2
OSMB_ECOLIP0ADA7
osmB
b1283 JW1275 Osmotically-inducible lipoprotein BOuter membrane Lipoprotein (experimental).Proven signal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY240.336SpII2322.8573Pos+2=S00Yn9-17c22/23oCytoplasmicMembrane9.86
ECNA_ECOLIP0ADB4
ecnA
b4410 JW5737 Uncharacterized protein yfeNOuter membrane Lipoprotein (experimental).Small membrane protein detected experimentally. Proven pignal peptidase II substrate. PMID: 15174130PMID: 19121005 PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY230.254SpII1814.5257Pos+2=N00Yn5-16c21/22oCytoplasmicMembrane10
YIDQ_ECOLIP0ADM4
yidQ
b3688 JW5633 Uncharacterized protein yidQOuter membrane LipoproteinPMID: 11274153Inner Membrane LipoproteinEN/AOuter membrane Lipoprotein(experimental)SECLOLyesyesY270.185SpII2016.396Pos+2=S00Yn5-18c26/27oUnknown2114.11
FIMH_ECOLIP08191
fimH
b4320 JW4283 Protein fimHCell surface appendage Cell surface appendage Cell surface appendage Cell surface appendage Fim operon (class γ1); Potential tip-adhesin. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. PMID: 1971261 PMID: 2900235 PMID: 2890081 PMID: 20345943PMID: 19820722 PMID: 2890081 PMID: 20345943 PMID: 1971261 PMID: 2900235 PMID: 24140205Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbriumCell surface appendage (Experimental)fimbriaeSECCUnoyesY200.539SpI2114.3197-00Yn4-14c19/20oUnknown4.6519.94
CPDB_ECOLIP08331
cpdB
b4213 JW4171 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase (EC 3.1.3.6) (EC 3.1.4.16)Periplasm Periplasm (experimental). Periplasmic Periplasmic Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. References: Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 9298646 Disulfide bond-containing protein PMID: 25664544PMID: 18498364 PMID: 3005231 PMID: 15911532 PMID: 15911532 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSURAnoyesY200.787SpI1914.5002-00Yn4-14c19/20oPeriplasmic1082.97
DACC_ECOLIP08506
dacC
b0839 JW0823 D-alanyl-D-alanine carboxypeptidase dacC (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (Penicillin-binding protein 6) (PBP-6)Peripheral inner membrane protein facing the periplasm. Membrane anchored Peripheral inner membrane protein facing the periplasm.Peripheral inner membrane protein facing the periplasm. PMID: 9858669 DacC(PBP-6) anchors to the periplasmic face of the inner membrane via C-terminal amphiphilic alpha-helix. The Alpha-helical conformation in the C-terminal anchoring domain is observed in aqueous solution or in the presence of phospholipid vesicles. PMID: 9371419PMID: 8162192 PMID: 9858669 PMID: 9371419Peripheral inner membrane protein facing the periplasmF2Soluble IM FractionCell inner membrane | Peripheral membrane proteinMembrane anchored (Experimental)SECyesyesY280.887SpI2718.4084-00Yn11-22c27/28oCytoplasmicMembrane9.9721.34
YIDX_ECOLIP0ADM6
yidX
b3696 JW5858 Uncharacterized protein yidXOuter Membrane LipoproteinIN/AMembrane | Single-pass membrane proteinOuter membrane LipoproteinSECLOLpseudogene (Ochman & Davalos, 2006)noyesY290.411SpII2320.6632Pos+2=I10Yn11-21c26/27oUnknown254
YIFL_ECOLIP0ADN6
yifL
b4558 JW3781 Uncharacterized lipoprotein yifLOuter membrane protein (experimental). Membrane LipoproteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 16397293PMID: 15911532 PMID: 16397293Outer Membrane LipoproteinISoluble IM FractionCell membrane | Lipid-anchorMembrane Lipoprotein (Experimental)SECLOLnoyesY240.159SpII1927.2584Pos+2=G10Yn7-18c23/24oUnknown2
YGGE_ECOLIP0ADS6
yggE
b2922 JW2889 Uncharacterized protein yggEPeriplasmicGN/APeriplasmicSECyesyesY220.409SpI2116.0009-00Yn5-16c21/22oPeriplasmic9.76111.24
OMPT_ECOLIP09169
ompT
b0565 JW0554 Protease 7 (EC 3.4.23.49) (Omptin) (Outer membrane protein 3B) (Protease A) (Protease VII)Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel proteinSecB substrate. Trigger factor-sensitive aggregation. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 9298646PMID: 16352602 PMID: 19737520 PMID: 15911532 PMID: 12624733 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 11566868 PMID: 10806384 PMID: 21541338 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECB,TFSECBAMProphage Integrase (EcoGene)nonoY210.295SpI207.49489-00Yn5-16c20/21oOuterMembrane103.86
GLPQ_ECOLIP09394
glpQ
b2239 JW2233 Glycerophosphoryl diester phosphodiesterase (Glycerophosphodiester phosphodiesterase) (EC 3.1.4.46)Periplasm PeriplasmicPMID: 2829735 PMID: 1851953PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY260.712SpI2517.875-00Yn8-18c25/26oPeriplasmic1039.37
ARGT_ECOLIP09551
argT
b2310 JW2307 Lysine-arginine-ornithine-binding periplasmic protein (LAO-binding protein) Periplasmic Periplasmic This periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (hisJ) interact with a common membrane-bound receptor, hisP. Phosphorylated by ArgKPMID: 2136858. Identified DsbA substrate PMID: 19953543 PMID: 9298647 PMID: 9298646 Disulfide bridge (60 67) Disulfide bond-containing protein PMID: 25664544PMID: 2136858 PMID: 19953543 PMID: 9298647 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY230.595SpI2219.5206-00Yn4-14c22/23oPeriplasmic10
FLGH_ECOLIP0A6S0
flgH

fla FVIII flaY

fla FVIII flaYb1079 JW5153 Flagellar L-ring protein (Basal body L-ring protein)Outer membrane Lipoprotein (experimental). Outer membrane protein (experimental). Proven pignal peptidase II substrate. L ring protein. PMID: 15174130PMID: 15174130 PMID: 12631703 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorBacterial flagellum basal bodyOuter membrane Lipoprotein (Experimental)flagellumSECLOLyesyesY240.235SpII2117.0713Pos+2=A00Yn14-25c33/34oOuterMembrane1024.76
YGIW_ECOLIP0ADU5
ygiW
b3024 JW2992 Protein ygiWPeriplasmicSecB substrate. PMID: 9298646PMID: 16352602 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECBSECyesyesY210.877SpI2026.1756-00Yn4-15c20/21oUnknown2.528.78
LPTA_ECOLIP0ADV1
lptA

yhbN

yhbNb3200 JW3167 Lipopolysaccharide export system protein lptAPeriplasmic. Periplasm PeriplasmicPMID: 17056748 PMID: 18480051 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic(experimental)SECyesyesY280.838SpI2724.4302-00Yn12-23c27/28oUnknown2.523.4
MLAC_ECOLIP0ADV7
mlaC

yrbC

yrbCb3192 JW3159 Probable phospholipid-binding protein mlaC PeriplasmicPMID: 15911532PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY220.509SpI2114.0896-00Yn8-16c21/22oUnknown2.561.74
FLGI_ECOLIP0A6S3
flgI

fla FIX flaM

fla FIX flaMb1080 JW1067 Flagellar P-ring protein (Basal body P-ring protein) Periplasmic P ring protein. Substrate of periplasmic disulfide oxidoreductases DsbA. Might be is co-translationally translocated through Sec translocon. Identified DsbA substrate PMID: 19953543 PMID: 12730325 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024PMID: 14726535 PMID: 12631703 PMID: 15838024 PMID: 19953543 PMID: 12730325 PMID: 15838024PeriplasmicGN/APeriplasmBacterial flagellum basal bodyPeriplasmic (Experimental)flagellumSRP (exp)SECDSBAFlanoyesY200.783SpI1915.6262-00Yn4-14c19/20oPeriplasmic1063.67
TOLB_ECOLIP0A855
tolB
b0740 JW5100 Protein tolBPeriplasm Periplasmic SecB substrate. Might be is co-translationally translocated through Sec translocon. PMID: 17233825 PMID: 7929011 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024PMID: 16352602 PMID: 15838024 PMID: 7929011 PMID: 17233825 PMID: 15838024PeriplasmicGSoluble IM FractionPeriplasmPeriplasmic (Experimental)SECB, SRPSECnoyesN220.555SpI217.66433-00Yn7-16c21/22oPeriplasmic1031.59
YCEI_ECOLIP0A8X2
yceI
b1056 JW1043 Protein yceIPeriplasmic Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350PMID: 9298646 PMID: 22030350PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY230.827SpI2223.1728-00Yn4-15c22/23oUnknown2.569.38
BLC_ECOLIP0A901
blc

yjeL

yjeLb4149 JW4110 Outer membrane lipoprotein blcOuter membrane Lipoprotein (experimental). Outer membrane protein (experimental). Proven pignal peptidase II substrate. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 15174130PMID: 15174130 PMID: 20932056 PMID: 21541338Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY190.216SpII1814.624Pos+2=S00Yn3-15c20/21oOuterMembrane1052.35
YHHA_ECOLIP0ADX7
yhhA
b3448 JW3413 Uncharacterized protein yhhA (ORFQ)PeriplasmicGN/APeriplasmicSECyesyesY180.377SpI1714.5283-00Yn4-11c17/18oUnknown2.5107.69
CREA_ECOLIP0AE91
creA

yjjD

yjjDb4397 JW4360 Protein creA Identified DsbA substrate PMID: 19953543 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 25664544PeriplasmicGN/APeriplasmicSECDSBAyesyesY220.8SpI2114.9398-00Yn6-16c21/22oUnknown2.5
YJBE_ECOLIP0AF45
yjbE
b4026 JW3986 Uncharacterized protein yjbEPeriplasmicGN/APeriplasmicSECnoyesY220.853SpI2125.8362-00Yn4-15c21/22oExtracellular9.65
YJCO_ECOLIP0AF56
yjcO
b4078 JW4039 Uncharacterized protein yjcO Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY180.752SpI1713.9637-00Yn4-13c17/18oUnknown2.582.96
BAMC_ECOLIP0A903
nlpB

dapX nlpB

dapX nlpBb2477 JW2462 Lipoprotein 34Lipoprotein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Cell outer membrane Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein related to resistance to ampicillin and tetracycline. Part of bam complex. Forms subcomplex with BamCE. Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384PMID: 16372265 PMID: 21823654 PMID: 21139201 PMID: 21370981 PMID: 15174130 PMID: 12488465 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 16079137 PMID: 20932056 PMID: 10806384 PMID: 21541338Outer Membrane LipoproteinISoluble IM FractionCell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN320.177SpII2417.2458Pos+2=S00Yn13-23c27/28oOuterMembrane1086.64
SLYB_ECOLIP0A905
slyB
b1641 JW1633 Outer membrane lipoprotein slyBLipoprotein (experimental). Inner membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384PMID: 15174130 PMID: 15911532 PMID: 10806384 PMID: 20932056 PMID: 10806384 PMID: 21541338Outer Membrane LipoproteinISoluble IM FractionCell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN220.181SpII1719.9051Pos+2=V00Yn5-16c21/22oOuterMembrane9.92
MIPA_ECOLIP0A908
mipA

yeaF

yeaFb1782 JW1771 MltA-interacting proteinOuter Membrane ss-barrel protein Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental).MipA is considered to be a structural protein mediating the assembly of MltA to PBP1B into a complexPMID: 10037771. MipA couples both enzymes to one another in vivo, it is likely to give rise to a membrane adhesion site as depicted. Such contacts between the membranes. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy 2000,Thein 2010)PMID: 15911532PMID: 10806384PMID: 12624733PMID: 20932056 PMID: 10037771PMID: 10037771 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 16079137 PMID: 20932056Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane β-barrel protein (Experimental)SECBAMyesyesY230.835SpI2221.2923-00Yn6-17c22/23oOuterMembrane1011.35
YJFN_ECOLIP0AF82
yjfN
b4188 JW5742 Uncharacterized protein yjfNPeriplasmicGN/APeriplasmPeriplasmicSECyesyesN200.293SpI217.51366-00Yn4-15c23/24oUnknown2104.21
YJFY_ECOLIP0AF86
yjfY
b4199 JW4157 Uncharacterized protein yjfYPeriplasmicGN/APeriplasmPeriplasmicSECyesyesY210.833SpI2015.6931-00Yn5-15c20/21oUnknown2.593.7
PSIF_ECOLIP0AFM4
psiF
b0384 JW5054 Phosphate starvation-inducible protein psiF Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY220.376SpI2113.709-10Yn5-16c21/22oUnknown244.48
RUTC_ECOLIP0AFQ5
rutC

ycdK

ycdKb1010 JW0995 UPF0076 protein rutC (Pyrimidine utilization protein C)PeriplasmicGN/APeriplasmicSECnoyesN460.249SpI242.38691-00Yn5-16c24/25oCytoplasmic9.2638.29
OMPA_ECOLIP0A910
ompA

con tolG tut

con tolG tutb0957 JW0940 Outer membrane protein A (Outer membrane protein II*)Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane Outer Membrane Outer Membrane Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel protein Substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA. Potential pubstrate of periplasmic chaperones Skp. Trigger factor-sensitive aggregation. Trigger factor-sensitive aggregation. Copurifies with trigger factor in pull down assays. The Lipid Bilayer-Inserted Membrane Protein BamA of Escherichia coli Facilitates Insertion and Folding of Outer Membrane Protein A from Its Complex with Skp. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 SecA is sufficient to transport a secretory protein with hydrophobic signal sequence across SecYEG, but efficient translocation requires SRP in Addition PMID: 24717922 Disulfide bridge (311 323) Disulfide bond-containing protein PMID: 25664544PMID: 8626309 PMID: 17908933 PMID: 19343722 PMID: 19737520 PMID: 23641708 PMID: 12488465 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 9808047 PMID: 7813480 PMID: 16079137 PMID: 21778229 PMID: 20932056 PMID: 10806384 PMID: 21541338 PMID: 19953543 PMID: 19953543 PMID: 19953543 PMID: 9298646 PMID: 24717922 PMID: 25664544Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)TFSECSKP,SURA,DEGP,DSBABAMyesyesY220.872SpI2128.1613-00Yn5-16c21/22oOuterMembrane1010.56
PAL_ECOLIP0A912
pal

excC

excCb0741 JW0731 Peptidoglycan-associated lipoproteinLipoprotein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) PMID: 10806384 PMID: 9298646PMID: 15174130 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 19364805 PMID: 23193105 PMID: 20932056 PMID: 10806384 PMID: 9298646Outer Membrane LipoproteinISoluble IM FractionCell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY290.5SpII2121.6668Pos+2=S00Yn6-14c18/19oOuterMembrane1081.44
OMPW_ECOLIP0A915
ompW

yciD

yciDb1256 JW1248 Outer membrane protein WOuter membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel proteinOuter membrane protein related to resistance to ampicillin and tetracycline. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) PMID: 9298646PMID: 16372265 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 16414958 PMID: 20932056 PMID: 10806384 PMID: 9298646Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane β-barrel protein (Experimental)SECBAMyesyesY220.754SpI2126.4914-00Yn4-15c21/22oOuterMembrane1042.93
YFIL_ECOLIP11289
yfiL
b2602 JW5412 Uncharacterized protein yfiL (URF2)Outer membrane Lipoprotein (experimental) Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLyesyesY260.211SpII1612.903Pos+2=Q00Yn5-14c19/20oUnknown2.559.3
YJJA_ECOLIP18390
yjjA
b4360 JW5795 Uncharacterized protein yjjA (Protein P-18) Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY260.86SpI2523.6068-00Yn8-19c25/26oUnknown2.5100.08
OMPX_ECOLIP0A917
ompX

ybiG

ybiGb0814 JW0799 Outer membrane protein XOuter membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel proteinSecB substrate. Substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA. Outer membrane proteins OmpF, OmpC, and OmpX as central to the YebF export mechanism. Trigger factor-sensitive aggregation. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 9298646PMID: 16352602 PMID: 19343722 PMID: 22658749 PMID: 19737520 PMID: 12488465 PMID: 15911532 PMID: 10806384 PMID: 11266632 PMID: 10545325 PMID: 20932056 PMID: 10806384 PMID: 21541338 PMID: 19953543 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECB,TFSECSURA,SKPBAMyesyesY240.63SpI2326.0753-10Yn4-15c23/24oOuterMembrane1014.31
PA1_ECOLIP0A921
pldA
b3821 JW3794 Phospholipase A1 (EC 3.1.1.32) (EC 3.1.1.4) (Detergent-resistant phospholipase A) (DR-phospholipase A) (Outer membrane phospholipase A) (OM PLA) (OMPLA) (Phosphatidylcholine 1-acylhydrolase) Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Potential Skp substrate PMID: 19953543 PMID: 6397464PMID: 12624733 PMID: 11266632 PMID: 10537112 PMID: 6397463 PMID: 20932056 PMID: 10806384 PMID: 19953543 PMID: 6397464Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECSKPBAMyesyesY210.528SpI207.74532-00Yn3-14c20/21oOuterMembrane109.69
TSX_ECOLIP0A927
tsx

nupA

nupAb0411 JW0401 Nucleoside-specific channel-forming protein tsxOuter membrane protein (experimental). Outer Membrane β-barrel protein (experimental). Outer membrane protein related to resistance to ampicillin and tetracycline. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 10806384PMID: 16372265 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 19953543Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECBAMProphage TransposaseyesnoY230.882SpI2224.8185-00Yn4-14c22/23oOuterMembrane100
YAAI_ECOLIP28696
yaaI
b0013 JW0012 UPF0412 protein yaaIPeriplasmicGN/APeriplasmicSECyesyesY240.727SpI239.88216-00Yn4-15c23/24oUnknown2.559.32
YBFC_ECOLIP28915
ybfC
b0704 JW0693 Uncharacterized protein ybfCPrediction of three weak transmembrane helixes (one with 0.6 probability) in Phobius.PeriplasmicGN/APeriplasmicSECnoyesY200.787SpI193.48234-00Yn4-15c19/20oUnknown248.41
YDCC_ECOLIP28917
ydcC
b1460 JW1455 H repeat-associated protein ydcC (ORF-H)PeriplasmicGIM (predicted)CytoplasmicSECTransposase, Rhs ElementnonoN420.169CYT0-0.200913-00Yn29-38c43/44oCytoplasmic8.9623.57
WZA_ECOLIP0A930
wza
b2062 JW2047 Putative polysaccharide export protein wzaOuter membrane, Lipoprotein. Lipoprotein (experimental). Surface exposed.Has a helical structure that crosses membrane. The transmembrane region of Wza is an alpha-helical barrel. Proven pignal peptidase II substrate. It has been demostrated that it can be also secreted and be surface exposed. PMID: 15174130PMCID: PMC3315050 PMID: 15174130 PMID: 10619844Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular spaceI, F4N/ACell outer membrane | Multi-pass membrane proteinOuter membrane Lipoprotein (Experimental)SECLOLyesyesY260.13SpII2012.3938Pos+2=T00Yn11-21c25/26oOuterMembrane9.9244.16
GFCE_ECOLIP0A932
gfcE

yccZ

yccZb0983 JW0966 Putative polysaccharide export protein gfcE (Group 4 capsule protein E homolog)Lipoprotein (experimental). Outer membrane protein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane | Multi-pass membrane proteinOuter membrane Lipoprotein (Experimental)SECLOLyesyesY230.202SpII2015.093Pos+2=T00Yn10-21c26/27oOuterMembrane9.9259.67
MLTA_ECOLIP0A935
mltA

mlt ygdM

mlt ygdMb2813 JW2784 Membrane-bound lytic murein transglycosylase A (EC 4.2.2.n1) (Mlt38) (Murein hydrolase A)Lipoprotein (experimental). Outer membrane protein (experimental). The formation of a complex between a murein polymerase (PBP1B) and a murein hydrolase (MltA). In the presence of MipA represents a first step in a reconstitution of the hypothetical murein-synthesizing holoenzyme. Postulated to be responsible for controlled growth of the stress-bearing sacculus of E.coli. Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) PMID: 15174130 SRP recognizes the first signal anchor sequence of a polytopic membrane protein (MtlA) resulting in cotranslational targeting of MtlA to SecY and phospholipids of the plasma membrane. PMID: 10619852 Possible interaction of SRP with the secretory protein pOmpA is prevented by the association of trigger factor with nascent pOmpA. PMID: 10619852PMID: 15174130 PMID: 10037771 PMID: 12624733 PMID: 20932056 PMID: 10619852 PMID: 10619852Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLpseudogene (Ochman & Davalos, 2006)noyesY200.191SpII2022.7365Pos+2=S00Yn9-19c23/24oOuterMembrane1035.58
BAME_ECOLIP0A937
smpA

smpA

smpAb2617 JW2598 Small protein ACell outer membrane Outer membrane protein (experimental).Part of BAM complex. Forms subcomplex with BamCE.PMID: 21823654 PMID: 21139201 PMID: 21370981 PMID: 17404237 PMID: 20932056Outer Membrane LipoproteinISoluble IM FractionCell outer membrane | Lipid-anchorOuter membrane LipoproteinSECLOLyesyesY240.197SpII1919.5033Pos+2=S00Yn5-16c20/21oOuterMembrane9.9244.38
MARB_ECOLIP31121
marB
b1532 JW1525 Multiple antibiotic resistance protein marBPeriplasmicGN/APeriplasmicSECnoyesY220.602SpI2118.3001-00Yn4-15c21/22oUnknown2.560.83
YDEI_ECOLIP31130
ydeI
b1536 JW1529 Uncharacterized protein ydeIPeriplasmicGN/APeriplasmicSECnoyesY200.882SpI1913.7979-00Yn3-14c19/20oUnknown2.5100.85
YIBG_ECOLIP32106
yibG
b3596 JW3570 Uncharacterized protein yibG (ORF-A3)PeriplasmicGN/APeriplasmicSECnoyesY200.567SpI190.904394-00Yn3-14c19/20oUnknown218.53
BAMA_ECOLIP0A940
bamA

yaeT yzzN yzzY

yaeT yzzN yzzYb0177 JW0172 Outer membrane protein assembly factor yaeT (Omp85)Outer membrane protein (experimental). Outer Membrane Outer membrane protein (experimental). Outer Membrane ss-barrel proteinPart of bam complexPMID: 21823654PMID: 21370981. Folding of OmpA from its complex with the periplasmic chaperone Skp into bilayers composed of phosphatidylethanolamine and phosphatidylcholine was inhibited in the absence of BamA but facilitated when BamA was present, indicating an interaction of Skp-OmpA complexes with BamAPMID: 23641708. Outer membrane protein determined by 2D gel electrophoresis (PMID: 15911532,PMID: 12624733,PMID: 20932056) Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 21823654 PMID: 21370981 PMID: 19525348 PMID: 23641708 PMID: 12624733 PMID: 10806384 PMID: 16079137 PMID: 20932056 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membraneOuter Membrane ss-barrel protein(experimental)SECBAMyesyesY210.641SpI2010.5737-00Yn6-13c20/21oOuterMembrane1032.48
PANE_ECOLIP0A9J4
panE

apbA

apbAb0425 JW0415 2-dehydropantoate 2-reductase (EC 1.1.1.169) (Ketopantoate reductase) (KPA reductase) (KPR)Cytoplasmic Lipoprotein CytoplasmicPhobious predicts the sequence that follows signal peptide as non cytoplasmic and non transmembrane. The native enzyme exists in solution as a monomer with a molecular mass of 34 000 Da. PMID: 10736170 Lipoprotein PMID: 10572132 PMID: 15174130 PMID: 10736170PMID: 10736170 PMID: 10572132 PMID: 15174130Outer Membrane LipoproteinIIM (predicted)CytoplasmCytoplasmic (Experimental)SECLOLyesyesN210.133SpII192.5798Pos+2=K00Yn5-16c20/21oCytoplasmic8.9631.23
PTA_ECOLIP0A9M8
pta
b2297 JW2294 Phosphate acetyltransferase (EC 2.3.1.8) (Phosphotransacetylase)Trigger factor-sensitive aggregation. Deletion of the ackA gene alone or together with Pta showed acetic acid accumulation. The deletion mutants of the gene encoding phosphotransacetylase secrete pyruvate before the secretion of acetate.PMID: 19737520 PMID: 21796982 PMID: 23194590 PMID: 20703804 PMID: 7765717PeriplasmicGIM (predicted-detected)CytoplasmCytoplasmicSRP,TFSECnoyesN670.109SpI221.30744-00Yn7-17c22/23oCytoplasmic9.2654.45
YIIQ_ECOLIP32160
yiiQ
b3920 JW3891 Uncharacterized protein yiiQPeriplasmicGN/APeriplasmicSECyesyesY240.736SpI2314.7775-00Yn4-15c23/24oUnknown2.5
YIIX_ECOLIP32167
yiiX
b3937 JW3908 Uncharacterized protein yiiXPeriplasmicGN/APeriplasmicSECnoyesY190.818SpI1814.7441-00Yn5-13c18/19oUnknown2.527.16
YIJF_ECOLIP32668
yijF
b3944 JW3916 Uncharacterized protein yijFPeriplasmicGN/APeriplasmicSECyesyesY190.257SpI2011.5911-00Yn3-14c18/19oUnknown2.514.94
TRXB_ECOLIP0A9P4
trxB
b0888 JW0871 Thioredoxin reductase (TRXR) (EC 1.8.1.9) Disulfide bridge (136 139) PMID: 8114095PMID: 8114095PeriplasmicGN/ACytoplasmCytoplasmicSECyesyesN260.317SpI256.69011-00Yn9-17c25/26oCytoplasmic10104.59
YEAY_ECOLIP0AA91
yeaY
b1806 JW1795 Uncharacterized lipoprotein yeaYLipoprotein (experimental). Outer membrane protein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN270.138SpII2214.0614Pos+2=V00Yn10-20c25/26oOuterMembrane9.9225.94
YAFK_ECOLIP0AA99
yafK
b0224 JW0214 Putative L,D-transpeptidase YafK (EC 2.-.-.-)PeriplasmicGN/APeriplasmicSECyesyesY200.74SpI1910.678-10Yn4-22c27/28oUnknown2.525.56
YBIS_ECOLIP0AAX8
ybiS
b0819 JW0803 Probable L,D-transpeptidase YbiS (EC 2.-.-.-)Peripheral outer membrane protein facing the periplasm (experimental). Periplasmic Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. YbiS has been shown to crosslink Braun's lipoprotein (Lpp) to the peptidoglycan. PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350PMID: 18498364 PMID: 23832002 PMID: 9298646 PMID: 22030350Peripheral outer membrane protein facing the periplasmF3N/APeriplasmPeriplasmic (Experimental)SECSURAyesyesY250.584SpI2419.8413-10Yn8-19c24/25oUnknown2.540.5
YMBA_ECOLIP0AB10
ymbA
b0952 JW5127 Uncharacterized lipoprotein ymbAputative protase (enterobacterium homolog)Inner Membrane LipoproteinEN/ACell membrane | Lipid-anchorCytoplasmicSECLOLyesyesN200.205SpII1522.8198Pos+2=S00Yn4-14c19/20oUnknown282.33
YJAH_ECOLIP32681
yjaH
b4001 JW3965 Uncharacterized protein yjaHOuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLyesyesN360.151SpII306.9142Pos+2=S00Yn20-28c46/47oUnknown2.525.12
YJBG_ECOLIP32688
yjbG
b4028 JW3988 Uncharacterized protein yjbGPeriplasmicGN/APeriplasmicSECyesyesY210.827SpI2017.0485-00Yn5-15c20/21oCytoplasmicMembrane9.86
NRFG_ECOLIP32712
nrfG

yjcN

yjcNb4076 JW4037 Formate-dependent nitrite reductase complex subunit nrfGOuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLyesyesN350.209SpII216.47674Pos+2=V10Yn11-22c30/31oUnknown264.76
YEHE_ECOLIP33344
yehE
b2112 JW2099 Uncharacterized protein yegJYeh operon is homolog to fim operon (yehd is fimI homolog).PMID: 20345943PeriplasmicGN/APeriplasmicSECnoyesY230.529SpI2211.8793-00Yn6-17c22/23oCytoplasmicMembrane9.8649.18
EFEO_ECOLIP0AB24
efeO

ycdO

ycdOb1018 JW1003 UPF0409 protein ycdOPeriplasm Periplasmic Identified DsbA substrate PMID: 19953543 PMID: 12107143 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544PMID: 16551627 PMID: 19953543 PMID: 12107143 PMID: 22030350 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY270.767SpI2618.2235-00Yn9-18c26/27oPeriplasmic1042.79
YCEB_ECOLIP0AB26
yceB
b1063 JW1050 Uncharacterized lipoprotein yceBLipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinISoluble IM FractionCell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN550.134SpII1816.4921Pos+2=N00Yn4-15c19/20oUnknown245.35
LPOB_ECOLIP0AB38
lpoB

ycfM

ycfMb1105 JW5157 Uncharacterized protein ycfMLipoprotein (experimental). Cell outer membrane Cell outer membrane Outer membrane protein (experimental).The two OM Lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase activity, thereby facilitating attachment of new peptidoglycans to the PG sacculus. Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 21183073 PMID: 21183074 PMID: 20932056Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLyesyesY240.258SpII1923.7759Pos+2=V00Yn8-18c22/23oUnknown296.82
APBE_ECOLIP0AB85
apbE

yojK yojL

yojK yojLb2214 JW5368 Thiamine biosynthesis lipoprotein ApbELipoprotein (experimental).Proven signal peptidase II substrate.PMID: 15174130Inner Membrane LipoproteinEIM (predicted)Cell membrane | Lipid-anchorInner membrane lipoproteinSECLOLyesyesN280.154SpII1912.0176Pos+2=D00Yn8-18c22/23oUnknown265.6
CSGB_ECOLIP0ABK7
csgB
b1041 JW1024 Minor curlin subunitCell surface appendage Cell surface appendage Cell surface appendageCurli component. CsgB localization requires at least one component of the curli secretion apparatus, CsgF. Curli are a functional amyloid whose in vivo polymerization requires a dedicated nucleator protein, CsgB, and an assembly protein, CsgF. Without CsgF, curli subunits are released from the cell into the media and are inefficiently polymerized, resulting in fewer and mislocalized curli fibers. PMID: 19131513 PMID: 9383186 PMID: 9312041PMID: 16704339 PMCID: PMC2630086 PMID: 21645131 PMID: 19131513 PMID: 19131513 PMID: 9383186 PMID: 9312041Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbrium. Part of the curli surface structure.Cell surface appendage (Experimental)CurliSECCurliyesyesY220.53SpI2116.29-00Yn5-13c21/22oExtracellular9.65
PPDA_ECOLIP33554
ppdA
b2826 JW2794 Prepilin peptidase-dependent protein APeriplasmicGN/APeriplasmicSECyesyesN270.172TMH07.10154-11="0"i12-33oCytoplasmicMembrane9.8210.54
YBBC_ECOLIP33668
ybbC
b0498 JW0487 Uncharacterized protein ybbCOuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLnoyesY180.367SpII178.97285Pos+2=N00Yn6-17c25/26oUnknown2.548.94
ASR_ECOLIP36560
asr
b1597 JW5826 Acid shock proteinPeriplasmicPMID: 12670971PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY220.907SpI2128.9272-00Yn4-15c21/22oPeriplasmic10
NRFA_ECOLIP0ABK9
nrfA
b4070 JW4031 Cytochrome c-552 (EC 1.7.2.2) (Ammonia-forming cytochrome c nitrite reductase) (Cytochrome c nitrite reductase)Periplasmic Disulfide bond-containing protein PMID: 25664544PMID: 793493 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY270.665SpI2614.744-00Yn11-21c26/27oPeriplasmic1025.45
NRFB_ECOLIP0ABL1
nrfB

yjcI

yjcIb4071 JW4032 Cytochrome c-type protein nrfBPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 15280383 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY330.498SpI256.62799-00Yn7-18c23/24oPeriplasmic9.8416.12
NAPB_ECOLIP0ABL3
napB

yejY

yejYb2203 JW5367 Diheme cytochrome c napBPeriplasm Periplasm Periplasm Periplasm Nitrate reductase, napFDAGHBC, is located in the periplasm. E. coli also expresses two membrane-bound proton-translocating nitrate reductases, encoded by the narGHJI and narZYWV operons. PMID: 11844760 PMID: 10234835 Disulfide bond-containing protein PMID: 25664544PMID: 10234835 PMID: 10548535 PMID: 17130127 PMID: 11844760 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY280.825SpI2714.6891-00Yn9-20c27/28oPeriplasmic10
SFMA_ECOLIP0ABW5
sfmA
b0530 JW0519 Sfm fimbrial protein, A chain (Type-1A pilin)Potential fimbrial sfm operon (class γ1); Fimbrial Subunit. Disulfide bridge (41 81) PMID: 19820722 PMID: 20345943 PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECCUyesyesY230.832SpI2221.4596-00Yn6-17c22/23oExtracellular1083.3
SURA_ECOLIP0ABZ6
surA
b0053 JW0052 Chaperone surA (Peptidyl-prolyl cis-trans isomerase surA) (PPIase surA) (EC 5.2.1.8) (Rotamase surA) (Survival protein A)Periplasmic PMID: 21370981 PMID: 19525348 PMID: 9298646 PMID: 22030350 PMID: 14506253PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY210.795SpI2015.5107-00Yn7-15c20/21oPeriplasmic1086.14
YIAT_ECOLIP37681
yiaT
b3584 JW3556 Putative outer membrane protein yiaTPMID: 20639525Outer Membrane b-barrel proteinHN/ACell outer membrane | Peripheral membrane proteinOuter Membrane β-barrel proteinSECnoyesY220.602SpI2111.315-00Yn7-17c21/22oOuterMembrane1022.26
YTFJ_ECOLIP39187
ytfJ
b4216 JW4175 Uncharacterized protein ytfJPeriplasmicPMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic(experimental)SECyesyesY210.734SpI2013.6826-00Yn6-14c22/23oUnknown2.518.26
YQJC_ECOLIP42616
yqjC
b3097 JW5516 Protein yqjCPeriplasmicGN/APeriplasmicSECyesyesY210.508SpI209.52426-00Yn5-15c20/21oUnknown2.579.95
BAMD_ECOLIP0AC02
bamD

yfiO

yfiOb2595 JW2577 UPF0169 lipoprotein yfiOOuter membrane Lipoprotein Lipoprotein (experimental). Outer membrane protein. Outer membrane protein (experimental). Cell outer membrane Outer membrane protein (experimental).Part of bam complex. Forms subcomplex with BamCE. Outer membrane protein related to resistance to ampicillin and tetracycline. YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 16372265PMID: 16372265 PMID: 15174130 PMID: 16824102 PMID: 21823654 PMID: 21139201 PMID: 21370981 PMID: 12488465 PMID: 15911532 PMID: 16079137 PMID: 20932056Outer Membrane LipoproteinISoluble IM FractionCell outer membrane | Lipid-anchorOuter membrane Lipoprotein(experimental)SECLOLyesyesY240.171SpII1927.0165Pos+2=S00Yn7-17c22/23oOuterMembrane1022.46
YEEZ_ECOLIP0AD12
yeeZ
b2016 JW1998 Protein yeeZPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAyesyesN250.197SpI246.50377-00Yn4-12c24/25oCytoplasmic8.9639.47
IVY_ECOLIP0AD59
ivy

ykfE

ykfEb0220 JW0210 Inhibitor of vertebrate lysozymePeriplasmic Experimentally verified gene-product. Verified that the signal peptide is cleaved. PMID: 11278658 Disulfide bridge (85 90) Disulfide bond-containing protein PMID: 25664544PMID: 9868784 PMID: 11278658 PMID: 25664544PeriplasmicGSoluble IM FractionPeriplasmPeriplasmic (Experimental)SECyesyesY290.849SpI2816.6514-00Yn13-23c28/29oPeriplasmic1027.17
LIVJ_ECOLIP0AD96
livJ
b3460 JW3425 Leu/Ile/Val-binding protein (LIV-BP) Periplasmic Substrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 Disulfide bridge (76 101) Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 19953543 PMID: 9298646 PMID: 22030350 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY240.832SpI2320.6668-00Yn7-18c23/24oPeriplasmic1096.06
YHCE_ECOLIP45421
yhcE
b4569 b3217Putative uncharacterized protein yhcEPotential fimbrial yhc operon (class β); Uknown function.PMID: 20345943PeriplasmicGN/ACell outer membrane | Multi-pass membrane proteinPeriplasmicfimbriaeSECpseudogene (Uniprot)nonoY200.69SpI194.02903-00Yn4-11c16/17oUnknown220.63
YHCF_ECOLIP45422
yhcF
b3219 JW3188 Uncharacterized protein yehDPotential fimbrial yhc operon (class β); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY210.835SpI2016.471-00Yn6-16c20/21oUnknown2.57.33
HOFP_ECOLIP45750
hofP

yrfA

yrfAb3392 JW5694 Uncharacterized protein yrfANo transmembrane helix is predicted. Weak hydrophobic and non cytoplasmic regions predicted by Phobius.PeriplasmicGIM (predicted-detected)CytoplasmicSECnoyesN210.138CYT0-0.200913-00Yn6-16c20/21oUnknown2
TESA_ECOLIP0ADA1
tesA

apeA pldC

apeA pldCb0494 JW0483 Acyl-CoA thioesterase I (EC 3.1.2.-) (Lecithinase B) (Lysophospholipase L1) (EC 3.1.1.5) (Protease I)PeriplasmicPMID: 8098033PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesN270.484SpI2611.0906-10Yn12-22c26/27oPeriplasmic1040.74
NLPD_ECOLIP0ADA3
nlpD
b2742 JW2712 Lipoprotein nlpDOuter membrane Lipoprotein (experimental) Outer membrane protein (experimental).Proven signal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell inner membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY250.134SpII2521.9047Pos+2=S00Yn13-24c29/30oOuterMembrane9.9385.13
YAJG_ECOLIP0ADA5
yajG
b0434 JW0424 Uncharacterized lipoprotein yajGOuter membrane protein (experimental). Outer membrane protein (experimental). Outer membrane LipoproteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 9298646PMID: 15911532 PMID: 20932056 PMID: 9298646Outer Membrane LipoproteinISoluble IM FractionCell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY200.403SpII1719.0402Pos+2=A00Yn5-15c19/20oUnknown2.5
OSME_ECOLIP0ADB1
osmE

anr

anrb1739 JW1728 Osmotically-inducible lipoprotein E (Activator of ntr-like gene protein)Lipoprotein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane Lipoprotein Proven signal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384 Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 15911532 PMID: 20932056 PMID: 21541338 PMID: 10806384 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionCell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY240.207SpII2020.0226Pos+2=T10Yn7-18c23/24oUnknown298.73
ECNB_ECOLIP0ADB7
ecnB

yjeU

yjeUb4411 JW4108 Entericidin BOuter membrane Lipoprotein (experimental). Outer membrane protein (experimental). Potentially toxic protein. Proven pignal peptidase II substrate. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 15174130PMID: 15174130 PMID: 19121005 PMID: 20932056 PMID: 21541338Outer Membrane LipoproteinISoluble IM FractionCell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY220.27SpII2117.5085Pos+2=N10Yn5-15c20/21oCytoplasmicMembrane10
YAJI_ECOLIP46122
yajI
b0412 JW5056 Uncharacterized lipoprotein yajIOuter Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane LipoproteinSECLOLnoyesY240.215SpII1918.9902Pos+2=V00Yn8-18c23/24oUnknown288.04
YFIM_ECOLIP46126
yfiM
b2586 JW2570 Uncharacterized protein yfiMContains the following signature IPR018736 Protein of unknown function DUF2279,Periplasmic lipoproteinInner Membrane LipoproteinEN/ACytoplasmicSECLOLyesyesY200.599SpII1415.2395Pos+2=S00Yn3-13c18/19oCytoplasmicMembrane9.8612.64
YGGM_ECOLIP46142
yggM
b2956 JW2923 Uncharacterized protein yggMPeriplasmicGN/APeriplasmicSECyesyesY220.874SpI2116.8631-00Yn5-16c21/22oPeriplasmic9.8432.42
LPTE_ECOLIP0ADC1
lptE

rlpB

rlpBb0641 JW0636 LPS-assembly lipoprotein lptE (Rare lipoprotein B)Lipoprotein (experimental). Outer membrane protein (experimental). Outer membrane Lipoprotein Proven signal peptidase II substrate. PMID: 16861298PMID: 15174130 PMID: 20932056 PMID: 16861298 PMID: 22901060Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN250.125SpII1817.3262Pos+2=G00Yn4-15c20/21oOuterMembrane1080.93
TAMA_ECOLIP0ADE4
tamA

yftM ytfM

yftM ytfMb4220 JW4179 Translocation and assembly module TamAOuter Membrane Outer MembranePart of the translocation and assembly module (TAM). TAM system promotes efficient secretion of autotransporters in proteobacteria.PMID: 17214547 PMID: 22466966Outer Membrane b-barrel proteinHN/AOuter Membrane β-barrel proteinSECBAMyesyesY220.861SpI2111.5811-00Yn7-15c21/22oOuterMembrane10
YIAF_ECOLIP0ADK0
yiaF
b3554 JW5655 Uncharacterized protein yiaFUncharacterized protein yiaF - echolocation Occurrence of signal peptide determined by LipoP signal sequence shown based upon lipoP, not possible to determine which membrane based on +2 amino acid rule.Inner Membrane LipoproteinESoluble IM FractionMembrane LipoproteinSECLOLyesyesN280.132SpII2510.3533Pos+2=F10Yn10-21c26/27oUnknown2.567.16
YGGN_ECOLIP0ADS9
yggN
b2958 JW2925 Uncharacterized protein yggNPeriplasmic Substrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 14726535PMID: 14726535 PMID: 19953543PeriplasmicGN/APeriplasmic(experimental)SECDSBAyesyesY210.797SpI2021.2471-00Yn6-16c20/21oUnknown2.580.23
ACRA_ECOLIP0AE06
acrA

lir mtcA

lir mtcAb0463 JW0452 Acriflavine resistance protein ALipoprotein (experimental). Inner membrane. Cell inner membrane. Inner membrane lipoproteinProven signal peptidase II substrate. PMID: 10894736PMID: 15174130 PMID: 15228545 PMID: 16079137 PMID: 10894736Inner Membrane LipoproteinESoluble IM FractionCell inner membrane | Lipid-anchorInner membrane lipoprotein (Experimental)SECLOLyesyesY220.194SpII2419.636Pos+2=D00Yn6-16c21/22oCytoplasmicMembrane1064.7
CSGC_ECOLIP52107
csgC
b1043 JW1026 Curli assembly protein CsgCUniprot mentions an 8aa signal peptide but Signal P prediction is for a "typical" 22 residue peptide Disulfide bond-containing protein PMID: 25664544 Disulfide bond-containing protein PMID: 25664544PMID: 21645131 PMID: 19131513 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmicSECnoyesN220.179SpI222.07115-00Yn4-16c21/22oUnknown2.568.8
YFJT_ECOLIP52135
yfjT
b2637 JW2618 Uncharacterized protein yfjTPeriplasmicGN/APeriplasmicSECProphage Integrase (EcoGene)nonoY240.673SpI2319.2157-00Yn9-19c23/24oUnknown2.522.23
HSLJ_ECOLIP52644
hslJ

ydbI

ydbIb1379 JW1374 Heat shock protein hslJOuter membrane Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLyesyesY250.238SpII1616.4623Pos+2=V00Yn4-15c20/21oUnknown2106.74
APHA_ECOLIP0AE22
aphA

napA yjbP

napA yjbPb4055 JW4015 Class B acid phosphatase (EC 3.1.3.2)Periplasm PeriplasmicPMID: 9011040 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY260.643SpI2514.5914-00Yn7-17c25/26oUnknown2.5
CPXP_ECOLIP0AE85
cpxP

yiiO

yiiOb4484 JW5558 Periplasmic protein CpxPPeriplasmic. Membrane associated PeriplasmNovel bacterial periplasmic protein with no homologues of known function. CpxP is thought to interact with the two-component sensor kinase, CpxA, to inhibit induction of the Cpx envelope stress response in the absence of protein misfolding. CpxP has also been shown to facilitate DegP-mediated proteolysis of misfolded proteins. PMID: 21317318PMID: 17904518 PMID: 10972835 PMID: 21317318Peripheral inner membrane protein facing the periplasmF2N/APeriplasmMembrane associated (Experimental)SECpseudogene (Ochman & Davalos, 2006)yesyesY220.806SpI2116.0374-00Yn3-14c21/22oPeriplasmic10104.98
CSGE_ECOLIP0AE95
csgE
b1039 JW1022 Curli production assembly/transport component csgEPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Curli secretion specificity factor. CsgE provides substrate specificity to the curli secretion pore CsgG, and acts directly on the secretion substrate CsgA to prevent premature subunit assembly. PMID: 9928475PMID: 16704339 PMID: 18498364 PMID: 21645131 PMID: 19131513 PMID: 9928475PeriplasmicGN/APeriplasmic (Experimental)CurliSECSURAyesyesY230.789SpI223.89784-00Yn7-17c22/23oUnknown215.08
CSGF_ECOLIP0AE98
csgF
b1038 JW1021 Curli production assembly/transport component csgFOuter membrane protein. Peripheral outer membrane protein facing the periplasm. Peripheral outer membrane protein facing the periplasm. Cell surface appendage PeriplasmicCurli component. CsgF is secreted to the cell surface, where it mediates the cell-association and protease-resistance of the CsgB nucleator, suggesting that CsgF is required for specific localization and/or chaperoning of CsgB for full nucleator activity. Curli are a functional amyloid whose in vivo polymerization requires a dedicated nucleator protein, CsgB, and an assembly protein, CsgF. Without CsgF, curli subunits are released from the cell into the media and are inefficiently polymerized, resulting in fewer and mislocalized curli fibers. PMID: 19131513 PMID: 9928475PMID: 16704339 PMID: 16522795 PMID: 21645131 PMID: 19131513 PMID: 19131513 PMID: 9928475Peripheral outer membrane protein facing the extra-cellular spaceF4N/APeriplasmic (Experimental)CurliSECCurliyesyesY200.853SpI1913.9164-10Yn6-14c19/20oExtracellular9.6430.3
CSGG_ECOLIP0AEA2
csgG
b1037 JW1020 Curli production assembly/transport component csgGOuter membrane Lipoprotein (experimental)Curli component. Proven signal peptidase II substrate. CsgG is an outer membrane protein required for the secretion of the two curli structural subunits CsgA and CsgB. CsgG is a lipoprotein that spans the outermembrane and assembles into an oligomeric annular-shaped structure with an inner diameter of approximately 2 nm (Margery L. Evans and Matthew R. Chapman in press). Overexpression of CsgG results in increased sensitivity to the small antibiotic erythromycin (740Da) but not the larger vancomycin (1440Da) suggesting that CsgG has a pore-like activity (Robinson et al 2006). PMID: 15174130PMID: 16704339 PMID: 15174130 PMID: 21645131 PMID: 16420357 PMID: 19131513Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular spaceI, F4N/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)CurliSECLOLyesyesY200.544SpII1512.9163Pos+2=L00Yn4-13c18/19oCytoplasmicMembrane9.8244.19
RZOD_ECOLIP58041
rzoD
b4510 JW5080 Outer membrane lipoprotein Rz1 from lambdoid prophage DLP12 Disulfide bridge (29 29) Outer Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLProphage Integrase (EcoGene)nonoY200.187SpII1919.9508Pos+2=T00Yn8-18c22/23oUnknown2147.46
RZOR_ECOLIP58042
rzoR
b4528 JW5213 Outer membrane lipoprotein Rz1 from lambdoid prophage Rac Disulfide bridge (29 29) Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane LipoproteinSECLOLProphage Integrase (EcoGene)nonoY200.189SpII1920.8844Pos+2=T00Yn8-18c22/23oUnknown288.14
DACA_ECOLIP0AEB2
dacA

pfv

pfvb0632 JW0627 D-alanyl-D-alanine carboxypeptidase dacA (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (Beta-lactamase) (EC 3.5.2.6) (Penicillin-binding protein 5) (PBP-5)Peripheral inner membrane protein facing the cytoplasm (experimental). Peripheral inner membrane protein facing the cytoplasm (experimental). Peripheral inner membrane protein facing the cytoplasm (experimental). Membrane anchored Membrane anchored Peripheral inner membrane protein facing the periplasm.Anchored to inner membrane by C-terminal tailPMID: 2194801. Using natural isotope abundance NMR, the structure of the PBP 5 anchor peptide within a micelle was determinedPMID: 20192190. The structure conforms to a helix-bend-helix-turn-helix motif and reveals that the anchor enters the membrane so as to form an amphiphilic structure within the interface of the hydrophilic/hydrophobic boundary regions near the lipid head groups. PBP-5 deletion mutants exhibit irregular distribution of MreB at the deformed zones PMID: 20545860. PMID: 3279397 PMID: 8424800 DacA(PBP-5) anchors to the periplasmic face of the inner membrane via C-terminal amphiphilic alpha-helix. The Alpha-helical conformation in the C-terminal anchoring domain is observed in aqueous solution or in the presence of phospholipid vesicles. A pH dependent loss of alpha-helical conformation in the peptide corresponding to the PBP5 C-terminus was found to correlate with the susceptibility of PBP5 to membrane extraction. PMID: 9371419PMID: 2194801 PMID: 20192190 PMID: 20545860 PMID: 24057063 PMID: 3279397 PMID: 8424800 PMID: 9371419Peripheral inner membrane protein facing the periplasmF2Soluble IM FractionCell inner membrane | Peripheral membrane protein | Cytoplasmic sideMembrane anchored (Experimental)SECyesyesY300.737SpI2917.6151-00Yn13-24c29/30oCytoplasmicMembrane9.978.45
DCRB_ECOLIP0AEE1
dcrB

yhhR

yhhRb3472 JW5682 Protein dcrBOuter membrane protein (experimental).PMID: 12558182 PMID: 15911532Inner Membrane LipoproteinESoluble IM FractionPeriplasmInner membrane lipoproteinSECLOLyesyesN300.169SpII1921.1Pos+2=D00Yn8-15c20/21oPeriplasmic10100.37
DEGS_ECOLIP0AEE3
degS

hhoB htrH

hhoB htrHb3235 JW3204 Protease degS (EC 3.4.21.-)Inner membrane anchored. Proteolysis of transmembrane and cytoplasmic portions of RseA by DegS frees the sigma(E) transcription factor. RseB protein, a known negative regulator, inhibits proteolysis by DegS in vitro by binding tightly to the periplasmic domain of RseA. PMID: 17360428PMID: 11442831 PMID: 17360428PeriplasmicGSoluble IM FractionPeriplasmMembrane anchoredSECyesyesN280.167SpI284.49468-10Yn9-20c28/29oPeriplasmic9.4475.55
YNBE_ECOLIP64448
ynbE
b1382 JW1377 Uncharacterized protein ynbEOuter membrane Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLnoyesN250.214SpII164.04646Pos+2=T00Yn4-15c24/25oUnknown2
YNCJ_ECOLIP64459
yncJ
b1436 JW1432 Uncharacterized protein yncJPeriplasmicGN/APeriplasmicSECnoyesY230.752SpI228.63896-00Yn5-16c22/23oUnknown2.538.04
YOAF_ECOLIP64493
yoaF
b1793 JW1782 Uncharacterized protein yoaFOuter membrane Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLnoyesY240.245SpII1620.7594Pos+2=S00Yn4-15c23/24oUnknown290.73
YEBY_ECOLIP64506
yebY
b1839 JW1828 Uncharacterized protein yebY Identified DsbA substrate PMID: 19953543PMID: 19953543PeriplasmicGN/APeriplasmicSECDSBAyesyesY210.862SpI2019.6801-10Yn5-12c20/21oUnknown2.535.83
DGAL_ECOLIP0AEE5
mglB
b2150 JW2137 Autoinducer 2 import ATP-binding protein lsrA (AI-2 import ATP-binding protein lsrA) (EC 3.6.3.-) (EGO10A) Periplasmic Periplasmic Potential Skp substrate PMID: 19953543 PMID: 7012152 PMID: 9298646PMID: 19953543 PMID: 7012152 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSKPnoyesY240.861SpI2323.7963-10Yn5-16c23/24oPeriplasmic1075.23
DSBA_ECOLIP0AEG4
dsbA

dsf ppfA

dsf ppfAb3860 JW3832 Thiol:disulfide interchange protein DsbAPeriplasmic Periplasmic disulfide isomerase DsbC cooperates with SurA and the thiol oxidase DsbA in the folding of the essential β-barrel protein LptD. DsbA is co-translationally translocated through Sec translocon. PMID: 9298646 DsbA, is a substrate for the SRP pathway. PMID: 15838024 DsbA, is a substrate for the SRP pathway. PMID: 13129941 Disulfide bridge (49 52) PMID: 9300489 Disulfide bond-containing protein PMID: 25664544PMID: 18406599 PMID: 20615876 PMID: 19525348 PMID: 13129941 PMID: 15838024 PMID: 9298646 PMID: 15838024 PMID: 13129941 PMID: 9300489 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SRP (exp)SECyesyesY200.75SpI1916.7987-00Yn4-15c19/20oPeriplasmic1071.65
DSBC_ECOLIP0AEG6
dsbC

xprA

xprAb2893 JW2861 Thiol:disulfide interchange protein DsbCPeriplasm Periplasmic Periplasmic disulfide isomerase DsbC cooperates with SurA and the thiol oxidase DsbA in the folding of the essential β-barrel protein LptD. PMID: 9298646 Disulfide bridge (118 121;161 183) PMID: 10700276 Disulfide bond-containing protein PMID: 25664544PMID: 18406599 PMID: 20615876 PMID: 8168498 PMID: 9298646 PMID: 10700276 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY210.778SpI2021.5074-00Yn4-15c20/21oPeriplasmic1082.33
FEPB_ECOLIP0AEL6
fepB
b0592 JW0584 Ferrienterobactin-binding periplasmic proteinPeriplasmicPMID: 10986237PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY270.581SpI2613.3736-00Yn10-21c26/27oPeriplasmic1030.41
FLIY_ECOLIP0AEM9
fliY

yzzR

yzzRb1920 JW1905 Cystine-binding periplasmic protein (CBP) (Protein fliY) (Sulfate starvation-induced protein 7) (SSI7)PeriplasmicPMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesN300.555SpI2910.7798-00Yn10-21c29/30oPeriplasmic1096.19
YOHN_ECOLIP64534
rcnB

yohN

yohNb2107 JW5346 Uncharacterized protein yehEPeriplasmPMID: 21665978PeriplasmicGN/APeriplasmicSECnoyesY220.81SpI2123.7077-10Yn8-16c21/22oUnknown2.579.93
YPEC_ECOLIP64542
ypeC
b2390 JW2387 Uncharacterized protein ypeCPeriplasmicGN/APeriplasmicSECnoyesY220.729SpI2114.9819-00Yn4-15c21/22oUnknown2.514.14
YFIR_ECOLIP64548
yfiR
b2603 JW2584 Uncharacterized protein yfiR Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY230.684SpI2213.4131-00Yn7-17c22/23oUnknown6.5821.98
GLNH_ECOLIP0AEQ3
glnH
b0811 JW0796 Glutamine-binding periplasmic protein (GlnBP)Periplasmic Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350PMID: 18498364 PMID: 9298646 PMID: 22030350PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSURAyesyesY230.851SpI2219.9168-00Yn7-18c22/23oPeriplasmic1062.21
HDEA_ECOLIP0AES9
hdeA

yhhC yhiB

yhhC yhiBb3510 JW3478 Chaperone-like protein hdeA (10K-S protein)Periplasm Periplasmic Experimentally verified gene-product. Verified that the signal peptide is cleaved. Falls into an unstructured form that is essential for its chaperone activity. The protein is dimeric at neutral pH but dissociates into a partially unfolded monomer at pH 2.0 PMID: 20080625. PMID: 8455549 Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 Disulfide bridge (39 87) Disulfide bond-containing protein PMID: 25664544PMID: 9868784 PMID: 10623550 PMID: 17085547 PMID: 20080625 PMID: 8455549 PMID: 25403562 PMID: 25403562 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECYfgMyesyesY220.698SpI2116.385-10Yn4-15c21/22oUnknown2.5108.01
HDEB_ECOLIP0AET2
hdeB

yhhD yhiC

yhhD yhiCb3509 JW5669 Protein hdeB (10K-L protein)Periplasm Periplasmic Experimentally verified gene-product. Verified that the signal peptide is cleaved. PMID: 8455550 Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 Disulfide bond-containing protein PMID: 25664544PMID: 9868784 PMID: 17085547 PMID: 8455550 PMID: 25403562 PMID: 25403562 PMID: 25664544PeriplasmicGN/APeriplasmic (Experimental)SECYfgMyesyesY300.837SpI2916.8932-00Yn10-21c29/30oUnknown2.563.24
HISJ_ECOLIP0AEU0
hisJ
b2309 JW2306 Histidine-binding periplasmic protein (HBP) Periplasmic Substrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bridge (60 67) Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 19953543 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY230.792SpI2220.7158-10Yn4-14c22/23oPeriplasmic10
YHCN_ECOLIP64614
yhcN
b3238 JW5540 Uncharacterized protein yhcNPeriplasmicGN/APeriplasmPeriplasmicSECyesyesY230.834SpI2222.7033-00Yn7-18c22/23oUnknown2.5
YHDV_ECOLIP64622
yhdV
b3267 JW3235 Uncharacterized protein yhdVOuter membrane Lipoprotein (experimental).Proven signal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIIM (predicted)Cell membrane | Multi-pass membrane proteinOuter membrane Lipoprotein (Experimental)SECLOLnoyesY210.268SpII1614.2179Pos+2=A11Yn4-15c20/21o50-71iUnknown2.530.35
YHFL_ECOLIP64627
yhfL
b3369 JW3332 Uncharacterized protein yhfLOuter membrane Lipoprotein (experimental). Inner membrane. Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 21890895Outer Membrane LipoproteinIN/AMembrane | Single-pass membrane proteinOuter membrane Lipoprotein (Experimental)SECLOLnoyesN220.162SpII1915.9797Pos+2=T00Yn7-17c22/23oUnknown2
YFGH_ECOLIP65290
yfgH
b2505 JW5400 Uncharacterized lipoprotein yfgHLipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinISoluble IM FractionCell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY270.349SpII2124.716Pos+2=Q00Yn7-17c22/23oUnknown2.573.25
SKP_ECOLIP0AEU7
skp

hlpA ompH

hlpA ompHb0178 JW0173 Chaperone protein skp (DNA-binding 17 kDa protein) (Histone-like protein HLP-1) (Seventeen kilodalton protein)Periplasm Periplasm Periplasm Periplasmic Periplasmic Folding of OmpA from its complex with the periplasmic chaperone Skp into bilayers composed of phosphatidylethanolamine and phosphatidylcholine was inhibited in the absence of BamA but facilitated when BamA was present, indicating an interaction of Skp-OmpA complexes with BamA. PMID: 2167239 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350PMID: 21370981 PMID: 19525348 PMID: 23641708 PMID: 2318304 PMID: 1838129 PMID: 8730870 PMID: 2167239 PMID: 9298646 PMID: 22030350PeriplasmicGN/APeriplasmPeriplasmic(experimental)SECyesyesY210.881SpI2022.0906-00Yn4-15c20/21oPeriplasmic1048.54
MALE_ECOLIP0AEX9
malE
b4034 JW3994 Maltose-binding periplasmic protein (MMBP) (Maltodextrin-binding protein) Periplasmic Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA. Sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. MalE is maintained in an unfolded conformation by the cytoplasmic chaperone SecB. Potential Skp substrate PMID: 19953543 PMID: 9298646 An amber mutation in the secA gene of Escherichia coli causes a pleiotropic decrease in the synthesis of secreted proteins. PMID: 3009404 Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 18498364 PMID: 1989077 PMID: 19953543 PMID: 9298646 PMID: 3009404 PMID: 25403562 PMID: 25403562PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SecBSECSURA,SKP,YfgMyesyesY270.712SpI2617.3972-00Yn9-17c26/27oPeriplasmic1096.4
MLTD_ECOLIP0AEZ7
mltD

dniR yafG

dniR yafGb0211 JW5018 Membrane-bound lytic murein transglycosylase D (EC 4.2.2.n1) (Murein hydrolase D) (Regulatory protein dniR)Lipoprotein (experimental). Outer membrane LipoproteinProven signal peptidase II substrate. PMID: 15174133PMID: 15174130 PMID: 15174133Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN270.22SpII1518.5563Pos+2=Q00Yn5-13c18/19oUnknown229.22
YJEI_ECOLIP0AF70
yjeI
b4144 JW5736 Uncharacterized protein yjeIOuter membrane Lipoprotein (experimental) Outer membrane protein (experimental). Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002) PMID: 15174130PMID: 12488465 PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinISoluble IM FractionOuter membrane Lipoprotein (Experimental)SECLOLyesyesY280.443SpII1820.5638Pos+2=S00Yn6-17c22/23oUnknown2.587.52
YGDR_ECOLIP65294
ygdR
b2833 JW2801 Uncharacterized lipoprotein ygdROuter membrane Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesN280.252SpII1915.677Pos+2=S10Yn6-17c22/23oUnknown2.5
YQHH_ECOLIP65298
yqhH
b3014 JW2982 Uncharacterized lipoprotein yqhHOuter membrane Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN240.242SpII1915.1531Pos+2=V10Yn4-17c22/23oOuterMembrane9.9317.87
NLPI_ECOLIP0AFB1
nlpI

yhbM

yhbMb3163 JW3132 Lipoprotein nlpIOuter membrane Lipoprotein (experimental) Proven pignal peptidase II substrate. PMID: 15174130 Induction of NlpI inhibits nucleoid division and halts cell growth. Elevation of NlpI expression enhances the transcription and the outer membrane localization of the heat shock protein IbpA and IbpB. NlpI physically interacts with IbpB. The C-terminus of NlpI is critical for the enhancement in IbpA and IbpB production, and the N-terminus of NlpI is required for the outer membrane localization of NlpI, IbpA, and IbpB. PMID: 25699035PMID: 15174130 PMID: 25699035Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN260.209SpII1814.4676Pos+2=S00Yn8-19c31/32oCytoplasmicMembrane1056.21
OSMY_ECOLIP0AFH8
osmY
b4376 JW4338 Osmotically-inducible protein YPeriplasmic Periplasmic Extra-celullar Peripheral inner membrane protein facing the periplasm (potential). The most efficient excreting fusion partner, OsmY, was used as a carrier protein to excrete heterologous proteins into the medium. PMID: 18727129 The OsmY protein is an Escherichia coli 20 kDa outer membrane or periplasmic protein that is expressed in response to a variety of stress conditions, in particular, helping to provide protection against osmotic shock. One hypothesis is that OsmY prevents shrinkage of the cytoplasmic compartment by contacting the phospholipid interfaces surrounding the periplasmic space. The domain architecture of two BON domains alone suggests that these domains contact the surfaces of phospholipids, with each domain contacting a membrane PMID: 12175925PMID: 1317380 PMID: 9298646 PMID: 18727129 PMID: 12878000Periplasmic, Extra-cellularG, XN/APeriplasmPeriplasmic (Experimental)SECyesyesY290.787SpI2823.4143-00Yn12-23c28/29oPeriplasmic10108.86
PBP7_ECOLIP0AFI5
pbpG

yohB

yohBb2134 JW5355 D-alanyl-D-alanine endopeptidase (DD-endopeptidase) (EC 3.4.21.-) (Penicillin-binding protein 7) (PBP-7)PeriplasmicPMID: 7721700PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY260.58SpI2517.1021-00Yn6-17c25/26oPeriplasmic1082.72
POTD_ECOLIP0AFK9
potD
b1123 JW1109 Spermidine/putrescine-binding periplasmic protein (SPBP)Periplasmic Periplasmic Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350PMID: 1939142 PMID: 9298646 PMID: 22030350PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY240.865SpI2325.0348-00Yn8-18c23/24oPeriplasmic10
PTFB1_ECOLIP69808
fryB

ypdH

ypdHb2387 JW5389 Fructose-like phosphotransferase enzyme IIB component 1 (EC 2.7.1.69) (PTS system fructose-like EIIB component 1)PeriplasmicGN/ACytoplasmPeriplasmicSECyesyesY250.406SpI2111.3983-00Yn5-16c24/25oUnknown4.9994.5
NANC_ECOLIP69856
nanC

yjhA

yjhAb4311 JW5778 Probable N-acetylneuraminic acid outer membrane channel protein nanC (NanR-regulated channel) (Porin nanC)PeriplasmicGN/ACell outer membranePeriplasmicSECnoyesY240.708SpI2319.1942-00Yn6-15c23/24oOuterMembrane108.83
YAAX_ECOLIP75616
yaaX
b0005 JW0004 Uncharacterized protein yaaXPeriplasmicGN/APeriplasmicSECnoyesY240.841SpI2319.693-10Yn6-17c23/24oUnknown2.577.96
PPIA_ECOLIP0AFL3
ppiA

rot rotA

rot rotAb3363 JW3326 Peptidyl-prolyl cis-trans isomerase A (PPIase A) (EC 5.2.1.8) (Cyclophilin A) (Rotamase A)Periplasmic Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350PMID: 2190212 PMID: 22030350PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY250.753SpI2424.1414-00Yn4-15c24/25oPeriplasmic1073.9
PROX_ECOLIP0AFM2
proX

proU

proUb2679 JW2654 Glycine betaine-binding periplasmic protein Periplasmic Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Identified DsbA substrate PMID: 19953543 PMID: 3305496 Disulfide bridge (157 163) Disulfide bond-containing protein PMID: 25664544PMID: 18498364 PMID: 19953543 PMID: 3305496 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSURA,DSBAyesyesY220.863SpI2116.9579-00Yn5-16c21/22oPeriplasmic1052.14
SPR_ECOLIP0AFV4
spr

yeiV

yeiVb2175 JW2163 Lipoprotein sprOuter membrane Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY340.288SpII2611.4182Pos+2=S00Yn14-24c29/30oUnknown2.536.96
RSEB_ECOLIP0AFX9
rseB
b2571 JW2555 Sigma-E factor regulatory protein rseBPeriplasm. Periplasm. Periplasm.Responce to stress complex RpoE-RseA-RseB. Proteolysis of transmembrane and cytoplasmic portions of RseA by DegS frees the sigma(E) transcription factor. RseB protein, a known negative regulator, inhibits proteolysis by DegS in vitro by binding tightly to the periplasmic domain of RseA. PMID: 17360428 The N-terminal domain of RseA sequesters σE in the cytoplasmic membrane, preventing its association with core RNA polymerase. The C-terminal domain of RseA interacts with RseB, a periplasmic protein. PMID: 11777003 PMID: 11777003PMID: 9159523 PMID: 9159522 PMID: 17360428 PMID: 11777003PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY240.61SpI2310.5992-00Yn4-16c28/29oPeriplasmic9.7615.17
SUBI_ECOLIP0AG78
sbp
b3917 JW3888 Sulfate-binding protein (Sulfate starvation-induced protein 2) (SSI2)PeriplasmicPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 9298646PMID: 18498364 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSURAyesyesY200.802SpI1915.2757-00Yn4-14c19/20oPeriplasmic1070.13
YKGI_ECOLIP75687
ykgI
b0303 JW5039 Uncharacterized protein ykgIPeriplasmicGN/APeriplasmPeriplasmicSECnoyesY230.662SpI2216.2846-00Yn6-17c22/23oUnknown2.5
YAHO_ECOLIP75694
yahO
b0329 JW0321 Uncharacterized protein yahOPeriplasmicGN/APeriplasmPeriplasmicSECnoyesY220.85SpI2113.1005-00Yn8-16c21/22oUnknown2.585.68
YBFN_ECOLIP75734
ybfN

ybfN

ybfNb0682 JW0668 Uncharacterized lipoprotein ybfNOuter membrane Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY190.487SpII1619.5262Pos+2=A00Yn4-14c18/19oUnknown2.577.74
UGPB_ECOLIP0AG80
ugpB
b3453 JW3418 sn-glycerol-3-phosphate-binding periplasmic protein ugpB Periplasmic Identified DsbA substrate PMID: 19953543 PMID: 3062310 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 3062310 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY240.804SpI2317.1867-00Yn7-18c23/24oPeriplasmic1064.05
PSTS_ECOLIP0AG82
pstS

phoS

phoSb3728 JW3706 Phosphate-binding protein pstS (PBP)PeriplasmicPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Copurifies with trigger factor in pull down assays. PMID: 9298646PMID: 18498364 PMID: 19737520 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)TFSECSURAyesyesY260.546SpI2523.9055-10Yn6-17c25/26oPeriplasmic1079.81
SLT_ECOLIP0AGC3
slt

sltY

sltYb4392 JW4355 Soluble lytic murein transglycosylase (EC 4.2.2.n1) (Exomuramidase) (Peptidoglycan lytic exotransglycosylase) (Slt70)Periplasmic Disulfide bridge (133 166) Disulfide bond-containing protein PMID: 25664544PMID: 1938883 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY280.803SpI2712.0915-00Yn11-22c27/28oPeriplasmic1010.89
MLTF_ECOLIP0AGC5
mltF

yfhD

yfhDb2558 JW2542 Membrane-bound lytic murein transglycosylase F (EC 4.2.2.n1) (Murein lyase F)Peripheral outer membrane protein.PMID: 18234673Peripheral outer membrane protein facing the periplasmF3N/ACell outer membrane | Peripheral membrane proteinPeriplasmicSECnoyesN330.227SpI303.07095-10Yn9-20c32/33oCytoplasmic9.2610.36
YBFP_ECOLIP75737
ybfP
b0689 JW0676 Uncharacterized lipoprotein ybfPLipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY250.444SpII2215.3591Pos+2=A10Yn7-20c24/25oUnknown2.551.52
GFCC_ECOLIP75883
gfcC

ymcB

ymcBb0985 JW0968 Uncharacterized protein gfcC (Group 4 capsule protein C homolog)PeriplasmicGN/APeriplasmicSECyesyesY230.723SpI228.45245-00Yn4-15c22/23oUnknown2.541.93
YMDA_ECOLIP75917
ymdA
b1044 JW1031 Uncharacterized protein YmdAPeriplasmicGN/APeriplasmicSECnoyesY230.463SpI2213.2508-10Yn11-22c28/29oExtracellular9.6536.55
SODC_ECOLIP0AGD1
sodC
b1646 JW1638 Superoxide dismutase [Cu-Zn] (EC 1.15.1.1) (Bacteriocuprein)Periplasmic Disulfide bridge (74 169) PMID: 9405149 Disulfide bond-containing protein PMID: 25664544PMID: 8626323 PMID: 9405149 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY200.82SpI1916.2903-00Yn4-14c19/20oPeriplasmic10
MLTC_ECOLIP0C066
mltC

yggZ

yggZb2963 JW5481 Membrane-bound lytic murein transglycosylase C (EC 4.2.2.n1) (Murein hydrolase C)Outer membrane Lipoprotein (experimental) Outer membrane protein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY240.3SpII1614.8852Pos+2=S00Yn5-15c20/21oUnknown217.78
MEPA_ECOLIP0C0T5
mepA
b2328 JW2325 Penicillin-insensitive murein endopeptidase (EC 3.4.24.-) (D-alanyl-D-alanine-endopeptidase) (DD-endopeptidase) Periplasmic Substrate of periplasmic disulfide oxidoreductases DsbC and DsbA. Identified DsbC substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 2187143 Disulfide bridge (44 265;187 235;216 223) Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 19953543 PMID: 19953543 PMID: 2187143 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBA,DSBCyesyesY200.847SpI1922.606-00Yn4-14c19/20oPeriplasmic1016.62
DEGP_ECOLIP0C0V0
degP

htrA ptd

htrA ptdb0161 JW0157 Periplasmic serine endoprotease DegPPeripheral inner membrane protein facing the periplasm. Periplasmic SecB substrate. Substrate of periplasmic disulfide oxidoreductases DsbA. HtrA was not detected by the immunoblotting technique in the periplasm or in the fraction of soluble proteins but was found in the inner membrane. DegP oligomerizes as a hexameric cage but in its presence DegP reorganizes into 12 and 24-mer cages with large chambers that house the substrate for degradation or refolding. Size exclusion chromatography and electron microscopy show that the size of the substrate molecule is the main factor conditioning the oligomeric state adopted by the enzyme. Identified DsbA substrate PMID: 19953543 PMID: 2180903 Disulfide bridges between 83 and 95 PMID: 12878036 Disulfide bridge (83 95) PMID: 12878036 Disulfide bond-containing protein PMID: 25664544PMID: 16352602 PMID: 14726535 PMID: 21370981 PMID: 19525348 PMID: 9083020 PMID: 21526129 PMID: 19953543 PMID: 2180903 PMID: 12878036 PMID: 12878036 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECBSECDSBAyesyesY270.841SpI2628.3128-00Yn4-19c26/27oPeriplasmic1031.01
FLGA_ECOLIP75933
flgA
b1072 JW1059 Flagella basal body P-ring formation protein flgAPeriplasmicPeriplasmic chaperone for P ring protein. PMID: 12730325PMID: 12631703 PMID: 12730325PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SEC FlayesyesY220.722SpI215.00523-00Yn8-16c21/22oPeriplasmic9.7612.09
YCFL_ECOLIP75946
ycfL
b1104 JW1090 Uncharacterized protein ycfLOuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLnoyesY240.214SpII1819.4253Pos+2=R00Yn5-16c21/22oUnknown270.14
YCGJ_ECOLIP76001
ycgJ
b1177 JW1166 Uncharacterized protein ycgJ Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY230.404SpI228.58297-00Yn6-16c24/25oUnknown2.577.92
EMTA_ECOLIP0C960
emtA

mltE sltZ ycgP

mltE sltZ ycgPb1193 JW5821 Endo-type membrane-bound lytic murein transglycosylase A (EC 4.2.2.n2) (Peptidoglycan lytic endotransglycosylase)Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY490.204SpII1518.8581Pos+2=S00Yn5-13c18/19oCytoplasmicMembrane9.8215.95
ACFD_ECOLIP0CK95
yghJ
b4466 JW5925 ECK2968Putative lipoprotein AcfD homologInner Membrane LipoproteinEN/ACell membrane | Lipid-anchorInner membrane lipoproteinSECLOLnoyesY230.283SpII2337.591Pos+2=D00Yn10-21c26/27oUnknown6.26
RLPA_ECOLIP10100
rlpA
b0633 JW0628 Rare lipoprotein AOuter membrane Lipoprotein (experimental) Outer membrane protein (experimental). Septal ring protein. Peripheral inner membrane protein facing the cytoplasm (experimental). Outer membrane protein (experimental). Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005). Contains a SPOR domain. PMID: 15174130PMID: 15174130 PMID: 12488465 PMID: 15911532 PMID: 19880599 PMID: 20932056Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN200.14SpII1719.3561Pos+2=T00Yn5-15c20/21oUnknown2.5
FADL_ECOLIP10384
fadL

ttr

ttrb2344 JW2341 Long-chain fatty acid transport protein (Outer membrane fadL protein) (Outer membrane flp protein)Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane. Outer Membrane Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel proteinSubstrate of periplasmic peptidyl prolyl cis–trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 1987139PMID: 19343722 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 15178802 PMID: 16079137 PMID: 20932056 PMID: 10806384 PMID: 19953543 PMID: 19953543 PMID: 1987139Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECSURA,SKPBAMyesyesY260.796SpI2516.4528-00Yn10-20c25/26oOuterMembrane101.16
PLIG_ECOLIP76002
pliG

ycgK

ycgKb1178 JW1167 Uncharacterized protein ycgKPeriplasm SecB substrate. Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 16352602 PMID: 20734102 PMID: 25403562 PMID: 25403562PeriplasmicGN/APeriplasmicSECBSECnoyesY230.798SpI2219.6754-00Yn9-17c22/23oUnknown2.572.87
IAP_ECOLIP10423
iap
b2753 JW2723 Alkaline phosphatase isozyme conversion protein (EC 3.4.11.-)Membrane associatedPMID: 3316184Peripheral inner membrane protein facing the periplasmF2N/AMembrane associated (Experimental)SECyesyesY250.707SpI2413.6553-00Yn9-20c24/25oUnknown4.925.51
FECA_ECOLIP13036
fecA
b4291 JW4251 Fe(3+) dicitrate transport protein fecA (Iron(III) dicitrate transport protein fecA)Outer membrane protein (experimental). Outer membrane. Outer membrane protein (experimental). Outer Membrane ss-barrel proteinSubstrate of periplasmic peptidyl prolyl cis–trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 2836368PMID: 19343722 PMID: 15911532 PMID: 12624733 PMID: 11266632 PMID: 11872840 PMID: 20932056 PMID: 19953543 PMID: 19953543 PMID: 2836368Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane β-barrel protein (Experimental)SECSURA,SKPBAMnoyesY340.831SpI3318.814-00Yn19-29c33/34oOuterMembrane101.41
TREA_ECOLIP13482
treA

osmA

osmAb1197 JW1186 Periplasmic trehalase (EC 3.2.1.28) (Alpha,alpha-trehalase) (Alpha,alpha-trehalose glucohydrolase) Periplasmic Potential Skp substrate PMID: 19953543 PMID: 2671658 Disulfide bond-containing protein PMID: 25664544 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 2671658 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSKPyesyesY310.702SpI3017.5054-00Yn13-26c30/31oPeriplasmic1070.34
CHIA_ECOLIP13656
chiA

yheB

yheBb3338 JW3300 Probable bifunctional chitinase/lysozyme [Includes: Chitinase (EC 3.2.1.14); Lysozyme (EC 3.2.1.17)]Cytoplasm; Periplasm. Periplasm Can be fully secreted when the cryptic T2S system is expressed. PMID: 10760150 Disulfide bridge (628 673) Disulfide bond-containing protein PMID: 25664544PMID: 11118204 PMID: 10760150 PMID: 25664544Periplasmic, Extra-cellularG, XN/APeriplasmPeriplasmic (Experimental)SECT2SnoyesY250.672SpI2420.7505-00Yn11-20c24/25oPeriplasmic10
YDBL_ECOLIP76076
ydbL
b1383 JW5216 Uncharacterized protein ydbLPeriplasmicGN/APeriplasmicSECyesyesY220.838SpI2115.5115-10Yn4-15c21/22oUnknown2.551.39
YNCH_ECOLIP76118
yncH
b1455 JW5235 Uncharacterized protein yncHPeriplasmicGIM (predicted)CytoplasmicSECnoyesN400.113CYT0-0.200913-00Yn2-13c18/19oUnknown235.64
FECB_ECOLIP15028
fecB
b4290 JW4250 Fe(3+) dicitrate-binding periplasmic protein (Iron(III) dicitrate-binding periplasmic protein)PeriplasmicPMID: 2651410PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY220.843SpI218.42911-00Yn7-16c21/22oPeriplasmic9.998.95
PHND_ECOLIP16682
phnD

psiD

psiDb4105 JW4066 Phosphonates-binding periplasmic proteinPeriplasmicPMID: 16751609PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY270.567SpI2616.4228-00Yn6-21c26/27oPeriplasmic10
PHNP_ECOLIP16692
phnP
b4092 JW4053 Protein phnPPeriplasmicPMID: 8335257PeriplasmicGN/APeriplasmic (Experimental)SECyesyesN210.153CYT0-0.200913-00Yn3-10c15/16oCytoplasmic9.26
CYSP_ECOLIP16700
cysP
b2425 JW2418 Thiosulfate-binding proteinPeriplasmicPMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY260.741SpI2514.3932-00Yn10-20c25/26oPeriplasmic1061.88
FHUE_ECOLIP16869
fhuE
b1102 JW1088 FhuE receptor (Outer-membrane receptor for Fe(III)-coprogen, Fe(III)-ferrioxamine B and Fe(III)-rhodotrulic acid)Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003)','Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) PMID: 3032906PMID: 10806384 PMID: 10806384 PMID: 3032906Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane β-barrel protein (Experimental)SECBAMnoyesY370.821SpI3620.6615-00Yn19-30c36/37oOuterMembrane100.86
RZPQ_ECOLIP76158
rzpQ

ydfP

ydfPb1553 JW1545 Uncharacterized protein rzpQPeriplasmicGN/APeriplasmicSECProphage Integrase (EcoGene)nonoN230.245SpI220.491707-10Yn7-17c22/23oUnknown219.08
YNFD_ECOLIP76172
ynfD
b1586 JW5259 Uncharacterized protein ynfDPeriplasmicExperimentally verified gene-product. PMID: 9868784PMID: 9868784PeriplasmicGSoluble IM FractionPeriplasmic (Experimental)SECnoyesY220.874SpI2122.7125-00Yn3-14c21/22oExtracellular9.6579.09
YDHO_ECOLIP76190
ydhO
b1655 JW5270 Uncharacterized protein ydhOPeriplasmicGN/APeriplasmicSECyesyesY280.421SpI2715.3587-00Yn8-19c27/28oUnknown6.49
CIRA_ECOLIP17315
cirA

cir feuA

cir feuAb2155 JW2142 Colicin I receptorInner membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane ss-barrel protein Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 10430870 Disulfide bond-containing protein PMID: 25664544PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 20932056 PMID: 10806384 PMID: 19953543 PMID: 19953543 PMID: 10430870 PMID: 25664544Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane β-barrel protein (Experimental)SECDSBA,SKPBAMyesyesY260.695SpI2511.8271-00Yn10-20c25/26oOuterMembrane1046.98
YFAA_ECOLIP17994
yfaA

pufY

pufYb2230 JW2224 Uncharacterized protein yfaAPeriplasmicGSoluble IM FractionPeriplasmicSECnoyesN310.233SpI305.42187-11="0"i12-31oCytoplasmicMembrane9.8689.6
GGT_ECOLIP18956
ggt
b3447 JW3412 Gamma-glutamyltranspeptidase (EC 2.3.2.2) [Cleaved into: Gamma-glutamyltranspeptidase large chain; Gamma-glutamyltranspeptidase small chain]Periplasm Periplasmic Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 1360205 PMID: 2570061 PMID: 25403562 PMID: 25403562PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECYfgMyesyesY260.723SpI2520.0548-00Yn10-21c25/26oPeriplasmic1036.63
AGP_ECOLIP19926
agp
b1002 JW0987 Glucose-1-phosphatase (G1Pase) (EC 3.1.3.10)Periplasmic Periplasmic Disulfide bond-containing protein PMID: 25664544PMID: 2153660 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY230.88SpI2221.9324-00Yn5-16c22/23oPeriplasmic1062.1
YDIY_ECOLIP76206
ydiY
b1722 JW1711 Uncharacterized protein ydiYPeriplasmicGN/APeriplasmicSECyesyesY260.481SpI2520.5374-00Yn7-18c23/24oUnknown2.515.66
YDJY_ECOLIP76220
ydjY
b1751 JW5283 Uncharacterized protein ydjY 4Fe-4S ferredoxin-type, iron-sulphur binding domain (IPR017896) Inner Membrane LipoproteinESoluble IM FractionInner membrane lipoproteinSECLOLnoyesN340.346SpII2615.9526Pos+2=D00Yn13-24c29/30oUnknown2.596.26
RNI_ECOLIP21338
rna

rnsA

rnsAb0611 JW0603 Ribonuclease I (RNase I) (EC 3.1.27.6) (Enterobacter ribonuclease) Periplasmic Substrate of periplasmic disulfide oxidoreductases DsbC and DsbA. Identified DsbA substrate PMID: 19953543 PMID: 2253883 Disulfide bridge (103 159) PMID: 14726535 PMID: 19953543 PMID: 2253883 PeriplasmicGN/APeriplasmCytoplasmPeriplasmic (Experimental)SECDSBA,DSBCyesyesY240.538SpI2515.6073-00Yn8-18c23/24oPeriplasmic1031.78
NMPC_ECOLIP21420
nmpC

phmA

phmAb0553 Putative outer membrane porin protein nmpCOuter Membrane ss-barrel proteinPMID: 337109Outer Membrane b-barrel proteinHN/AOuter Membrane ss-barrel protein(experimental)SECBAMpseudogene (Uniprot) yesnoY240.879SpI2325.1335-00Yn4-15c23/24oOuterMembrane1011.44
YCBB_ECOLIP22525
ycbB
b0925 JW0908 Probable L,D-transpeptidase YcbB (EC 2.-.-.-)Peripheral outer membrane protein facing the periplasm (experimental).YcbB forms direct meso- diaminopimelate (DAP-DAP, or 3-3) crosslinks within the peptidoglycan.PMID: 23832002Peripheral outer membrane protein facing the periplasmF3N/AMembrane | Single-pass membrane proteinPeriplasmicSECyesyesY310.448SpI3010.8337-00Yn11-22c30/31oPeriplasmic9.8463.67
ECOT_ECOLIP23827
eco

eti

etib2209 JW2197 EcotinPeriplasmic Periplasmic Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 9298646 Disulfide bridge (70 107) Disulfide bond-containing protein PMID: 25664544PMID: 15911532 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY210.889SpI2016.5012-00Yn4-15c20/21oPeriplasmic1085.11
OPPA_ECOLIP23843
oppA
b1243 JW1235 Periplasmic oligopeptide-binding protein Periplasmic SecB substrate. Potential Skp substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 Disulfide bridge (297 443) Disulfide bond-containing protein PMID: 25664544PMID: 16352602 PMID: 19953543 PMID: 19953543 PMID: 9298646 PMID: 22030350 PMID: 25664544PeriplasmicGSoluble IM FractionPeriplasmPeriplasmic (Experimental)SECBSECyesyesY270.825SpI2618.3169-10Yn8-18c26/27oPeriplasmic1073.74
YNJH_ECOLIP76227
ynjH
b1760 JW1749 Uncharacterized protein ynjH Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECnoyesY190.569SpI1811.8884-00Yn4-14c18/19oCytoplasmicMembrane9.8627.32
YECT_ECOLIP76296
yecT
b1877 JW5310 Uncharacterized protein yecTPeriplasmicGN/APeriplasmicSECnoyesY190.831SpI1811.1311-00Yn4-14c18/19oUnknown4.931.26
DPPA_ECOLIP23847
dppA
b3544 JW3513 Periplasmic dipeptide transport protein (Dipeptide-binding protein) (DBP)Periplasmic Periplasmic Substrate of periplasmic disulfide oxidoreductases DsbA. Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 Potential Skp substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bridge (34 262;450 463) Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 15911532 PMID: 19953543 PMID: 19953543 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBA,SKPyesyesY290.638SpI2816.4393-00Yn13-23c28/29oPeriplasmic1085.98
PSPE_ECOLIP23857
pspE
b1308 JW1301 Thiosulfate sulfurtransferase PspE (TST) (EC 2.8.1.1) (Phage shock protein E)Periplasmic Periplasm Experimentally verified gene-product. Verified that the signal peptide is cleaved. PMID: 9868784 Disulfide bond-containing protein PMID: 25664544PMID: 9868784 PMID: 1712397 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECProphage TransposaseyesnoY200.9SpI1920.0627-00Yn5-15c19/20oUnknown2.5
PRC_ECOLIP23865
prc

tsp

tspb1830 JW1819 Tail-specific protease (EC 3.4.21.102) (C-terminal-processing peptidase) (PRC protein) (Protease Re)Peripheral inner membrane protein facing the periplasm Periplasmic Fractionation of the maxicells producing the product or prc gene suggested that the product was associated with the periplasmic side of the cytoplasmic membrane. The prc gene, which is involved in cleavage of the C-terminal peptide from the precursor form of penicillin-binding protein 3 (PBP 3) of Escherichia coli. PMID: 1856173 PMID: 1729701PMID: 1856173 PMID: 1729701Peripheral inner membrane protein facing the periplasmF2N/ACell inner membrane | Peripheral membrane protein | Periplasmic sidePeriplasmic (Experimental)SECyesyesY230.786SpI2211.2952-00Yn7-17c22/23oCytoplasmicMembrane10
NLPC_ECOLIP23898
nlpC
b1708 JW1698 Probable lipoprotein nlpC (ORF-17)Outer membrane Lipoprotein (experimental) Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY210.325SpII1516.0698Pos+2=S00Yn3-13c17/18oUnknown2.534.05
FLHE_ECOLIP76297
flhE
b1878 JW1867 Flagellar protein flhEPart of the flagellar export apparatus Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECFlayesyesY170.511SpI168.24229-00Yn3-14c26/27oUnknown2.568.14
YECR_ECOLIP76308
yecR
b1904 JW1892 Uncharacterized protein yecRLipoprotein (experimental) Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLnoyesN250.325SpII158.98675Pos+2=T00Yn3-14c22/23oUnknown215.11
YOEA_ECOLIP76356
yoeA
b4582 JW1980 b1995 b1998Putative uncharacterized protein yoeAOuter Membrane b-barrel proteinHN/ACell inner membrane | Multi-pass membrane proteinOuter Membrane β-barrel proteinSECBAMpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoY290.402SpI288.15876-00Yn12-23c28/29oOuterMembrane9.93
ACRE_ECOLIP24180
acrE

envC

envCb3265 JW3233 Acriflavine resistance protein E (Protein envC)Lipoprotein (experimental). Lipoprotein (experimental).Proven pignal peptidase II substrate.PMID: 8472900 PMID: 15174130Inner Membrane LipoproteinEN/ACell inner membrane | Lipid-anchorInner membrane lipoproteinSECLOLyesyesY230.241SpII2310.9032Pos+2=N00Yn7-18c23/24oCytoplasmicMembrane9.9770.72
DACB_ECOLIP24228
dacB
b3182 JW3149 D-alanyl-D-alanine carboxypeptidase dacB (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (D-alanyl-D-alanine endopeptidase) (DD-endopeptidase) (EC 3.4.21.-) (Penicillin-binding protein 4) (PBP-4)Peripheral inner membrane protein facing the periplasm (experimental). Outer membrane protein (experimental). Membrane anchored Membrane anchored Peripheral inner membrane protein facing the periplasm.Exported from cytosol and signal peptide is cleaved. Anchored via C terminal the rest of the protein protudes into periplasm. Involved in peptidoglycan biosynthesis and is Penicillin-binding. PMID: 16411754 PMID: 15576782 DacB(PBP-4) anchors to the periplasmic face of the inner membrane via C-terminal amphiphilic alpha-helix. PMID: 9371419PMID: 12444970 PMID: 15911532 PMID: 16411754 PMID: 15576782 PMID: 9371419Peripheral inner membrane protein facing the periplasmF2N/APeriplasmMembrane anchored (Experimental)SECyesyesY210.58SpI2013.4163-00Yn6-16c20/21oPeriplasmic9.7634.4
VISC_ECOLIP25535
visC
b2906 JW2874 Protein visC (EC 1.-.-.-)Uncharacterized conserved visC gene is involved in Q biosynthesis in Escherichia coli (renamed as ubiI). Coenzyme Q (ubiquinone or Q) is a widespread redox-active lipid essential for electron and proton transport in the respiratory chains from bacteria to mammals. VisC/UbiL protein functions in the C5-hydroxylation reaction.PMID: 23709220 PMID: 17446142 PMID: 23194590Inner Membrane LipoproteinEIM (predicted-detected)Membrane LipoproteinSECLOLyesyesN200.198SpII190.428013Pos+2=G00="0"iCytoplasmic9.2649.32
ASLA_ECOLIP25549
aslA

atsA

atsAb3801 JW3773 Arylsulfatase (AS) (EC 3.1.6.1) (Aryl-sulfate sulphohydrolase)PeriplasmicGN/APeriplasmPeriplasmicSECnoyesY250.743SpI2417.5099-00Yn10-20c24/25oUnknown6.4925.41
YEGJ_ECOLIP76394
yegJ
b2071 JW2056 Uncharacterized protein YegJPeriplasmicGN/APeriplasmicSECnoyesY190.264SpI199.75379-00Yn4-14c19/20oUnknown2.579.39
YEGR_ECOLIP76406
yegR
b2085 JW5837 Uncharacterized protein yegROuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLyesyesY220.281SpII1715.1742Pos+2=A00Yn4-14c22/23oUnknown2.554.53
YFAT_ECOLIP76466
yfaT
b2229 JW2223 Uncharacterized protein yfaTPeriplasmicGN/APeriplasmicSECnoyesY200.277SpI193.99575-00Yn4-15c19/20oCytoplasmicMembrane9.8226.12
AMY1_ECOLIP25718
malS
b3571 JW3543 Alpha-amylase (EC 3.2.1.1) (1,4-alpha-D-glucan glucanohydrolase)Periplasmic Disulfide bridge (57 75;121 537) PMID: 9268356 Disulfide bond-containing protein PMID: 25664544PMID: 1544897 PMID: 9268356 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY180.764SpI1714.5348-00Yn3-11c17/18oPeriplasmic1025.14
END1_ECOLIP25736
endA
b2945 JW2912 Endonuclease-1 (EC 3.1.21.1) (Endonuclease I) (Endo I)Periplasm Periplasmic Identified DsbA substrate PMID: 19953543 PMID: 7867949 Disulfide bond-containing protein PMID: 25664544PMID: 4955462 PMID: 19953543 PMID: 7867949 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAnoyesY230.883SpI2222.5344-00Yn5-16c22/23oUnknown5.0299.73
LOIP_ECOLIP25894
yggG

yggG

yggGb2936 JW2903 Uncharacterized metalloprotease yggG (EC 3.4.24.-)Cell outer membrane Cell outer membrane Outer membrane protein (experimental). Disulfide bridge (53 108) PMID: 22491786PMID: 17909889 PMID: 22491786 PMID: 20932056 PMID: 22491786Outer Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLyesyesN350.146SpII1825.8287Pos+2=Q00Yn5-16c34/35oUnknown260.15
YDBD_ECOLIP25907
ydbD
b1407 JW5221 Uncharacterized protein ydbDPeriplasmicGN/APeriplasmicSECnoyesY250.744SpI247.29978-00Yn12-20c24/25oCytoplasmicMembrane9.8628.15
BGLH_ECOLIP26218
bglH

yieC

yieCb3720 JW3698 Cryptic outer membrane porin BglHOuter membrane Reconstitution experiments with lipid bilayer membranes defined BglH as a channel-forming component, i.e. it is an outer membrane porin. Can be easily removed from the outer membrane by treatment with detergent. PMID: 10027967 PMID: 10027967PMID: 10027967Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECBAMnoyesY260.64SpI2513.3498-00Yn6-17c25/26oOuterMembrane108.76
YFCO_ECOLIP76498
yfcO
b2332 JW2329 Uncharacterized protein yfcOPutative chaperone–usher fimbrial operon yfc (class π); Unkown functionPMID: 20345943PeriplasmicGSoluble IM FractionPeriplasmicfimbriaeSECnoyesY220.835SpI2114.5584-00Yn6-16c21/22oExtracellular9.6541.82
YFCQ_ECOLIP76500
yfcQ
b2334 JW2331 Uncharacterized fimbrial-like protein yfcQPutative chaperone–usher fimbrial operon yfc (class π); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECyesyesY190.841SpI1813.6429-00Yn4-11c18/19oUnknown2.596.19
AMIB_ECOLIP26365
amiB

yjeD

yjeDb4169 JW4127 N-acetylmuramoyl-L-alanine amidase AmiB (EC 3.5.1.28)PeriplasmicPMID: 12787347PeriplasmicGN/ASecretedPeriplasmic (Experimental)SECyesyesY230.861SpI2213.4392-00Yn9-17c22/23oUnknown2.530.63
BAX_ECOLIP27297
bax
b3570 JW5653 Protein baxPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA. Sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAyesyesY280.533SpI2713.0141-00Yn10-21c27/28oUnknown260.23
WECC_ECOLIP27829
wecC

rffD

rffDb3787 JW5599 UDP-N-acetyl-D-mannosamine dehydrogenase (EC 1.1.1.n3) (UDP-ManNAc 6-dehydrogenase)Outer Membrane ss-barrel proteinPMID: 3275612Outer Membrane b-barrel proteinHN/AOuter Membrane β-barrel protein (Experimental)SECBAMyesyesN240.249CYT0-0.200913-00Yn3-14c23/24oCytoplasmic9.9782.19
YIGE_ECOLIP27840
yigE
b4482 JW5591 Uncharacterized protein yigEPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURApseudogene (Ochman & Davalos, 2006)nonoY330.615SpI3210.2626-00Yn19-29c33/34oUnknown2.5
MLIC_ECOLIP28224
mliC

ydhA

ydhAb1639 JW1631 Membrane-bound lysozyme inhibitor of C-type lysozymeCell outer membrane Disulfide bridge (37 102) PMID: 16937244PMID: 18369469 PMID: 16937244Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane LipoproteinSECLOLyesyesY230.288SpII177.61087Pos+2=S00Yn6-15c20/21oUnknown253.07
YFCR_ECOLIP76501
yfcR
b2335 JW2332 Uncharacterized protein yfcRPutative chaperone–usher fimbrial operon yfc (class π); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECyesyesY290.68SpI2811.4125-00Yn10-22c30/31oUnknown2.549.6
YFDX_ECOLIP76520
yfdX
b2375 JW2372 Protein yfdXPeriplasmicPMID: 11157960PeriplasmicGN/APeriplasmic (Experimental)SECyesyesY220.881SpI2120.5809-00Yn4-15c21/22oUnknown2.549.64
YFFQ_ECOLIP76548
yffQ
b2448 Uncharacterized protein yffQPeriplasmicGN/APeriplasmicSECProphage Integrase (EcoGene)nonoN190.652SpI183.21713-00Yn3-13c18/19oUnknown4.9
YFGI_ECOLIP76573
yfgI
b2506 JW2490 Uncharacterized protein yfgIPeriplasmicGN/APeriplasmicSECnoyesY200.625SpI197.20342-00Yn4-14c32/33oUnknown2.511.76
CSGA_ECOLIP28307
csgA
b1042 JW1025 Major curlin subunitCell surface appendage Cell surface appendage Cell surface appendage Cell surface appendage Cell surface appendage Inner membraneCurli component. CsgA, is secreted from the cell in an unpolymerized form PMID: 11823641 The secretion and stability of CsgA and CsgB are dependent on the outer membrane lipoprotein CsgG. PMID: 21645131 Curli are a functional amyloid whose in vivo polymerization requires a dedicated nucleator protein, CsgB, and an assembly protein, CsgF. Without CsgF, curli subunits are released from the cell into the media and are inefficiently polymerized, resulting in fewer and mislocalized curli fibers. PMID: 19131513 PMID: 9383186 PMID: 9312041 During a process called interbacterial complementation, a csgB mutant cell secretes soluble CsgA that can be assembled on the surface of a cell expressing only csgB PMID: 8817489PMID: 16704339 PMID: 11823641 PMID: 21645131 PMID: 19131513 PMID: 9383186 PMID: 9312041 PMID: 8817489 PMID: 18710431Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbrium. Part of the curli surface structure.Cell surface appendage (Experimental)CurliSEC CurliyesyesY210.854SpI2020.7833-00Yn3-14c20/21oExtracellular9.6566.84
METQ_ECOLIP28635
metQ

yaeC

yaeCb0197 JW0193 D-methionine-binding lipoprotein metQLipoprotein (experimental). Inner membrane lipoprotein Proven pignal peptidase II substrate. PMID: 12218041PMID: 15174130 PMID: 12218041Inner Membrane LipoproteinESoluble IM FractionCell membrane | Lipid-anchorInner membrane lipoprotein (Experimental)SECLOLyesyesN250.18SpII2219.6725Pos+2=G00Yn7-18c23/24oCytoplasmicMembrane9.9785.92
GLTF_ECOLIP28721
gltF
b3214 JW3181 Putative lipoprotein rzoQIntegral inner membrane. PeriplasmicPutative chaperone–usher fimbrial operon (class β). Fimbrial Subunit. PMID: 10481090PMID: 20345943 PMID: 21890895 PMID: 10481090PeriplasmicGN/ACell membrane | Single-pass membrane proteinPeriplasmic (Experimental)fimbriaeSECnoyesY260.754SpI2526.3964-00Yn7-18c25/26oUnknown2.595.7
YHCA_ECOLIP28722
yhcA
b3215 JW3182 Uncharacterized protein yqeJPotential fimbrial yhc operon (class β); Usher.PMID: 20345943PeriplasmicGN/APeriplasmPeriplasmicfimbriaeSECnoyesN200.315CYT0-0.200913-00Yn5-13c21/22oCytoplasmic8.9626.55
FIMD_ECOLIP30130
fimD
b4317 JW5780 Outer membrane usher protein fimDOuter membrane protein Outer membrane protein. Outer Membrane ss-barrel protein Fim operon (class γ1); Usher. Οuter membrane protein related to resistance to ampicillin and tetracycline. Outer membrane protein determined by LC-MS (Gevaert et al 2002) Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Identified in the outer membrane by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 12842468 Disulfide bridge (855 877) PMID: 16372265 PMID: 20345943 PMID: 12488465 PMID: 12624733 PMID: 15911532 PMID: 12842468 PMID: 24140205Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)fimbriaeSECCUyesyesY380.415SpI371.20154-10Yn23-38c45/46oOuterMembrane10
YKFB_ECOLIP77162
ykfB
b0250 JW0239 Uncharacterized protein ykfB Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECProphage Integrase (EcoGene)nonoY240.716SpI2317.8556-00Yn11-19c23/24oUnknown2.559.81
ARTI_ECOLIP30859
artI
b0863 JW0847 Putative ABC transporter arginine-binding protein 2Periplasm Periplasmic Periplasmic Periplasmic Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 8801422 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544PMID: 8801422 PMID: 15911532 PMID: 15911532 PMID: 9298646 PMID: 22030350 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY200.883SpI1918.5986-00Yn4-15c19/20oPeriplasmic1076.54
ARTJ_ECOLIP30860
artJ
b0860 JW0844 ABC transporter arginine-binding protein 1Periplasm Periplasmic Identified DsbA substrate PMID: 19953543 PMID: 8801423 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350PMID: 8801422 PMID: 19953543 PMID: 8801423 PMID: 22030350PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY200.849SpI1918.9337-00Yn4-15c19/20oPeriplasmic1073.37
YADC_ECOLIP31058
yadC
b0135 JW0131 Uncharacterized fimbrial-like protein yadCCell surface appendagePMID: 19820722 PMID: 20345943 PMID: 20345943Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbriumPeriplasmicfimbriaeSECCUnoyesY230.677SpI2212.8917-10Yn8-17c22/23oExtracellular9.6414.72
YEDD_ECOLIP31063
yedD
b1928 JW1913 Uncharacterized lipoprotein yedDOuter membrane Lipoprotein (experimental) Outer membrane protein (experimental). Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Identified DsbA substrate PMID: 19953543 PMID: 15174130 Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 12488465 PMID: 15911532 PMID: 19953543 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionCell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECDSBALOLnoyesY200.338SpII1512.6143Pos+2=A00Yn4-12c16/17oUnknown2.5130.89
CUSF_ECOLIP77214
cusF

cusX ylcC

cusX ylcCb0573 JW0562 Cation efflux system protein cusFPeriplasmicPMID: 12813074PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY230.444SpI228.68332-00Yn4-15c22/23oPeriplasmic10
RNFG_ECOLIP77285
rnfG

ydgP

ydgPb1631 JW1623 Electron transport complex protein rnfG Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/ACell inner membranePeriplasmicSECyesyesY250.427SpI2411.9411-00Yn9-17c24/25oUnknown2.542.9
YBET_ECOLIP77296
ybeT
b0647 JW0642 Uncharacterized protein ybeTOuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLnoyesN220.112SpII185.89834Pos+2=I10Yn8-17c21/22oUnknown249.04
YDDL_ECOLIP77519
yddL
b1472 JW1468 Putative uncharacterized protein yddLPeriplasmicGN/APeriplasmicSECpseudogene (Ochman & Davalos, 2006)yesyesY220.898SpI2118.2436-00Yn5-16c21/22oOuterMembrane9.9348.14
POTF_ECOLIP31133
potF
b0854 JW0838 Putrescine-binding periplasmic proteinPeriplasmic Disulfide bridge (175 239) PMID: 9651355 Disulfide bond-containing protein PMID: 25664544PMID: 9298646 PMID: 9651355 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY270.731SpI2615.245-00Yn9-20c26/27oPeriplasmic1061.65
YIEL_ECOLIP31471
yieL
b3719 JW5612 Uncharacterized protein yieLPeriplasmicGN/APeriplasmicSECnoyesY240.659SpI2316.8534-00Yn5-16c23/24oUnknown2.5
THIB_ECOLIP31550
thiB

tbpA yabL

tbpA yabLb0068 JW0067 Thiamine-binding periplasmic proteinPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Disulfide bond-containing protein PMID: 25664544PMID: 18498364 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmicSECSURAnoyesY190.685SpI1810.962-00Yn5-13c18/19oPeriplasmic1022.25
LPTD_ECOLIP31554
lptD

imp ostA yabG

imp ostA yabGb0054 JW0053 LPS-assembly protein lptD (Organic solvent tolerance protein)Outer membrane protein (experimental). Outer Membrane Outer Membrane Outer membrane protein (experimental). Outer Membrane ss-barrel protein The Protein-disulfide Isomerase DsbC Cooperates with SurA and DsbA in the Assembly of LptD. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bridge (31 724;173 725) PMID: 20615876 PMID: 19343722 PMID: 15911532 PMID: 12724388 PMID: 16079137 PMID: 20932056 PMID: 19953543 PMID: 19953543 PMID: 19953543 PMID: 9298646 PMID: 22901060Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membraneOuter Membrane β-barrel protein (Experimental)SECDSBA,DSBC,SURA,SKPBAMyesyesY250.626SpI2418.6702-00Yn7-17c24/25oOuterMembrane10
SPY_ECOLIP77754
spy
b1743 JW1732 Spheroplast protein YPeriplasmicPMID: 9068658PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY240.817SpI2320.7622-00Yn4-15c23/24oPeriplasmic10104.11
LYSD_ECOLIP78285
rrrD

arrD ybcS

arrD ybcSb0555 JW0544 Probable lysozyme from lambdoid prophage DLP12 (EC 3.2.1.17) (Endolysin) (Lysis protein) (Muramidase)PeriplasmicGN/APeriplasmicSECProphage Integrase (EcoGene)nonoN220.149SpI214.27124-00Yn8-16c21/22oUnknown276.96
YSAB_ECOLIQ2M7M3
ysaB
b4553 JW3532 Uncharacterized lipoprotein ysaBOuter Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane LipoproteinSECLOLyesyesY270.418SpII1715.6662Pos+2=S00Yn5-16c26/27oUnknown236.16
NFRA_ECOLIP31600
nfrA
b0568 JW0557 UPF0214 protein yfeWOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003)PMID: 12624733Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane β-barrel proteinSECBAMnoyesY280.836SpI278.97469-00Yn10-21c27/28oOuterMembrane104.03
YADE_ECOLIP31666
yadE
b0130 JW0126 Uncharacterized protein yadEHomolog to C-terminus of DnaA which is a peripherally accossiated proteins with a C-terminal anchor.Peripheral inner membrane protein facing the periplasmF2N/APeriplasmicSECyesyesY200.838SpI1912.5161-10Yn5-15c19/20oUnknown2.512.24
FIMC_ECOLIP31697
fimC
b4316 JW4279 Chaperone protein fimCPeriplasmic Fim operon (class γ1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 1363735PMID: 18498364 PMID: 20345943 PMID: 1363735 PMID: 24140205PeriplasmicGN/APeriplasmPeriplasmic (Experimental)fimbriaeSECSURAyesyesN370.473SpI3611.9808-10Yn14-23c41/42oPeriplasmic10
YDDB_ECOLIP31827
yddB
b1495 JW1490 Uncharacterized protein yddB (CDS103)PeriplasmicGN/APeriplasmicSECnoyesN200.536SpI194.63803-00Yn4-14c19/20oOuterMembrane9.493.07
YICS_ECOLIQ2M7X4
yicS
b4555 JW5965 Uncharacterized protein yicS Non secreted. Uknown location Disulfide bond-containing protein PMID: 25664544 PMID: 25664544 novel bacterial periplasmic protein with no homologues of known function PMID: 21317318PMID: 25664544 PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesN220.681SpI2110.9898-00Yn4-14c21/22oUnknown2.5
PBL_ECOLIQ46790
pbl
b2854 Putative peptidoglycan-binding-like proteinPeriplasmicGN/APeriplasmCytoplasmicSECpseudogene (Uniprot)nonoY250.548SpI242.39101-00Yn8-19c24/25oPeriplasmic9.4428.8
YGEQ_ECOLIQ46797
ygeQ
b2863 JW5461 Putative uncharacterized protein ygeQPeriplasmicGN/APeriplasmicSECpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoY370.449SpI3611.1359-00Yn20-31c36/37oUnknown268.19
PQQL_ECOLIP31828
pqqL

yddC

yddCb1494 JW1489 Probable zinc protease pqqL (EC 3.4.24.-)Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGSoluble IM FractionCytoplasmicSECSURAnoyesN270.318SpI265.54177-10Yn8-20c26/27oCytoplasmicMembrane9.8637.95
YDEK_ECOLIP32051
ydeK

orfT

orfTb1510 JW1503 Uncharacterized lipoprotein ydeK (ORFT)Outer Membrane LipoproteinIN/ACytoplasmOuter membrane LipoproteinSECLOLpseudogene (Uniprot) nonoN620.164SpII180.949979Pos+2=S00="0"iOuterMembrane9.99
YIIG_ECOLIP32151
yiiG
b3896 JW3867 Uncharacterized protein yiiGLipoprotein (experimental). Proven pignal peptidase II substrate.PMID: 15174130Inner Membrane LipoproteinEN/AInner membrane lipoproteinSECLOLnoyesN220.152SpII2126.248Pos+2=D00Yn5-17c22/23oUnknown4.9106.68
YJBF_ECOLIP32687
yjbF
b4027 JW5711 Uncharacterized lipoprotein yjbFOuter membrane Lipoprotein (experimental) Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY210.427SpII1513.4041Pos+2=S00Yn5-13c18/19oUnknown2
YGHF_ECOLIQ46834
yghF
b2970 JW5484 Putative general secretion pathway protein C-type yghFPeriplasmicGN/APeriplasmCytoplasmicSECnoyesN430.145SpI161.1016-00Yn2-9c14/15oCytoplasmicMembrane9.8236.27
YGHG_ECOLIQ46835
yghG
b2971 JW2938 Uncharacterized lipoprotein yghGOuter membrane LipoproteinBelongs to the GSP C family. Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY290.253SpII2417.6171Pos+2=A00Yn10-22c27/28oUnknown2.540.56
YAIO_ECOLIQ47534
yaiO
b0358 JW0349 Uncharacterized protein yaiOTMBB-DB tool predicts this protein as an outer membrane beta barrel protein.PeriplasmicGN/APeriplasmicSECnoyesY200.841SpI1912.701-10Yn5-15c19/20oUnknown2.55.67
YJBH_ECOLIP32689
yjbH
b4029 JW3989 Uncharacterized lipoprotein yjbHInner Membrane LipoproteinEN/ACell membrane | Lipid-anchorMembrane LipoproteinSECLOLyesyesY210.41SpII1712.8674Pos+2=Y00Yn6-14c20/21oOuterMembrane9.52
MDTP_ECOLIP32714
mdtP

yjcP

yjcPb4080 JW4041 Multidrug resistance outer membrane protein mdtPOuter Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane LipoproteinSECLOLyesyesN230.147SpII234.25545Pos+2=A00Yn9-21c29/30oOuterMembrane9.9212.18
YJCS_ECOLIP32717
yjcS
b4083 JW5721 Uncharacterized protein yjcS Metallo-beta-lactamase family (IPR001279). Proteins of this family bind two zinc ions per molecule as cofactor. PeriplasmicGN/APeriplasmicSECyesyesY300.725SpI2916.7747-00Yn12-20c29/30oUnknown4.927.05
DACD_ECOLIP33013
dacD

phsE yeeC

phsE yeeCb2010 JW5329 D-alanyl-D-alanine carboxypeptidase dacD (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (Penicillin-binding protein 6b) (PBP-6b)Membrane anchoredPenicillin-binding protein 5 (PBP 5); membrane-bound cell wall dd-carboxypeptidase, localized in the outer leaflet of the cytosolic membrane. PMID: 8955390PMID: 20192190 PMID: 8955390Peripheral inner membrane protein facing the periplasmF2N/ACell inner membrane | Peripheral membrane proteinMembrane anchored (Experimental)SECyesyesY220.485SpI2112.6922-00Yn5-16c21/22oCytoplasmicMembrane9.9912.62
YFEK_ECOLIQ47702
yfeK
b2419 JW2412 Uncharacterized protein yfeKPeriplasmicGN/APeriplasmicSECnoyesY200.758SpI192.85333-00Yn4-15c19/20oUnknown2.577.15
YJDP_ECOLIQ6BEX5
yjdP
b4487 JW5890 Uncharacterized protein yjdPPeriplasmicGN/APeriplasmicSECnoyesY230.721SpI2214.9551-00Yn6-17c22/23oUnknown2.5
ECPD_ECOLIP33128
ecpD
b0140 JW0136 Chaperone protein ecpDPutative chaperone–usher fimbrial operon (class γ4); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364 PMID: 20345943PeriplasmicGN/APeriplasmPeriplasmicfimbriaeSECSURAnoyesY260.667SpI2516.6944-00Yn8-19c25/26oPeriplasmic10
HTRE_ECOLIP33129
htrE
b0139 JW0135 Outer membrane usher protein htrE (Heat shock protein E)Putative chaperone–usher fimbrial operon (class γ4); Usher. Disulfide bridge (838 862) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel proteinfimbriaeSECBAMnoyesY300.677SpI296.72527-00="0"iOuterMembrane108.62
OPGG_ECOLIP33136
mdoG

opgG

opgGb1048 JW1035 Glucans biosynthesis protein G PeriplasmicCopurifies with trigger factor in pull down assays. Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 19737520 PMID: 19953543 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)TFSECSKPyesyesY230.708SpI2216.361-00Yn6-17c22/23oPeriplasmic1023.5
YEBF_ECOLIP33219
yebF
b1847 JW1836 Protein yebF Extra-cellular Secreted and releasedOuter membrane proteins OmpF, OmpC, and OmpX are central to the YebF export mechanism. Identified DsbA substrate PMID: 19953543 PMID: 16369539 Disulfide bond-containing protein PMID: 25664544PMID: 22658749 PMID: 19953543 PMID: 25664544 PMID: 16369539 PMID: 16369539Extra-cellularXN/ASecretedSecreted and released (Experimental)SECOMVnoyesY220.777SpI2120.4773-00Yn5-16c21/22oExtracellular10108.11
YEHA_ECOLIP33340
yehA
b2108 JW2095 Uncharacterized fimbrial chaperone yhcAPutative chaperone–usher fimbrial operon yeh (class γ4); Unkown function.PMID: 16372265PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY210.622SpI207.58765-00Yn7-15c20/21oUnknown248.75
YEHB_ECOLIP33341
yehB
b2109 JW2096 Vitamin B12 transporter BtuB (Cobalamin receptor) (Outer membrane cobalamin translocator)Putative chaperone–usher fimbrial operon yeh (class γ4); Usher. Disulfide bridge (809 825) PMID: 16372265 Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel proteinfimbriaeSECBAMnoyesY230.679SpI2211.7505-00Yn7-18c22/23oOuterMembrane105.85
YEHC_ECOLIP33342
yehC
b2110 JW2097 Protein gltFPutative chaperone–usher fimbrial operon yeh (class γ4); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmPeriplasmicfimbriaeSECSURAnoyesN340.721SpI339.53077-10Yn18-29c33/34oPeriplasmic1043.6
YEHD_ECOLIP33343
yehD
b2111 JW2098 Uncharacterized protein ybcHPutative chaperone–usher fimbrial operon yeh (class γ4); Fimbrial Subunit. Disulfide bond-containing protein PMID: 25664544PMID: 19820722 PMID: 20345943 PMID: 25664544PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY230.891SpI2224.5442-10Yn4-15c22/23oUnknown2.595.56
YEHR_ECOLIP33354
yehR
b2123 JW5351 Uncharacterized lipoprotein yehROuter membrane Lipoprotein (experimental) Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY220.219SpII2222.3044Pos+2=G00Yn7-18c23/24oUnknown2.581.29
OSMF_ECOLIP33362
osmF

yehZ

yehZb2131 JW2119 Putative osmoprotectant uptake system substrate-binding protein osmF PeriplasmicPMID: 15911532PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSURAyesyesY240.77SpI2313.9464-00Yn6-17c23/24oCytoplasmicMembrane9.9772.03
BGLX_ECOLIP33363
bglX

yohA

yohAb2132 JW2120 Periplasmic beta-glucosidase (EC 3.2.1.21) (Beta-D-glucoside glucohydrolase) (Cellobiase) (Gentiobiase)PeriplasmicPMID: 8757730PeriplasmicGSoluble IM FractionPeriplasmPeriplasmic (Experimental)SECyesyesY210.824SpI206.29436-00Yn4-15c20/21oPeriplasmic1031.03
MDTQ_ECOLIP33369
mdtQ

yohG yohH

yohG yohHb2139 JW5838/JW5358 b2138Putative multidrug resistance outer membrane protein mdtQOuter Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorCytoplasmicSECLOLpseudogene (Ochman & Davalos, 2006)noyesY240.204SpII2110.0112Pos+2=A00Yn9-20c38/39oOuterMembrane102.52
NIKA_ECOLIP33590
nikA
b3476 JW3441 Nickel-binding periplasmic proteinPeriplasmic Might be is co-translationally translocated through Sec translocon. PMID: 7867647 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024 Zinc ion binding protein PMID: 15838024 PMID: 7867647 PMID: 15838024 PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SRP (exp)SECyesyesY230.82SpI2220.282-00Yn8-18c22/23oPeriplasmic10
YDBA_ECOLIP33666
ydbA
b4492 JW5802/JW1402 b1401/b1405Putative uncharacterized protein YdbAAg43 homologue; known autotransporter protein. Contains autotransporter beta-domain (IPR005546)PMID: 15590781Outer Membrane b-barrel proteinHIM (predicted)CytoplasmicSECAutotransporter(T5S)noyesY220.75SpI200="21"00Yn5-16c21/22oUnknown6.2628.13
YEJA_ECOLIP33913
yejA
b2177 JW2165 Uncharacterized protein yejAPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGSoluble IM FractionPeriplasmicSECSURAnoyesY200.634SpI199.78276-10Yn5-15c19/20oPeriplasmic1019.81
YEJO_ECOLIP33924
yejO
b2190 JW5839 Putative uncharacterized outer membrane protein yejOAg43 homologue; predicted autotransporter. Contains autotransporter beta-domain (IPR005546)PMID: 15590781Outer Membrane b-barrel proteinHN/ACytoplasm nucleoidcytoplasmicSECAutotransporter(T5S)Insertion Sequence, Insertion Element, pseudogene (Uniprot)nonoY300.756SpI297.15031-00Yn12-22c29/30oUnknown729.74
OMPP_ECOLIP34210
ompP
Outer membrane protease ompP (EC 3.4.23.-)Outer membrane protein (experimental).Belongs to the peptidase A26 family. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003)','Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000)PMID: 10806384Outer Membrane b-barrel proteinHN/A-SECPlasmid FnonoY240.662SpI2311.2434-00Yn5-16c23/24o
HOFQ_ECOLIP34749
hofQ

hopQ

hopQb3391 JW3354 Protein transport protein hofQOuter Membrane Secretin family, homologous to the secretin of T2S (P45758 (GSPD_ECOLI)); homologus to ComE of H.influenza involved in DNA uptake PMID: 16707682Outer Membrane b-barrel proteinHN/ACell outer membranePeriplasmicSECBAMyesyesY190.736SpI1910.1451-00Yn5-13c18/19oOuterMembrane1063.9
YACH_ECOLIP36682
yacH
b0117 JW0113 Uncharacterized protein yacHPeriplasmicGN/APeriplasmicSECyesyesY230.224SpI299.50022-00Yn11-21c26/27oExtracellular9.6413.05
PAGP_ECOLIP37001
pagP

crcA ybeG

crcA ybeGb0622 JW0617 Protein CrcAOuter membrane. Outer MembranePMID: 12357033 PMID: 11266632 PMID: 11013210Outer Membrane b-barrel proteinHN/AOuter Membrane β-barrel protein (Experimental)SECBAMnoyesN260.361CYT0-0.200913-00Yn7-18c25/26oOuterMembrane109.34
YADK_ECOLIP37016
yadK
b0136 JW0132 Uncharacterized protein yadKPutative chaperone–usher fimbrial operon (class γ4); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECyesyesY290.766SpI2816.7043-10Yn12-23c28/29oUnknown2.541.39
YADL_ECOLIP37017
yadL
b0137 JW0133 Uncharacterized protein yadLPutative chaperone–usher fimbrial operon (class γ4); Unkown function.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY290.815SpI2819.3349-10Yn11-22c28/29oUnknown2.523.6
YADM_ECOLIP37018
yadM
b0138 JW0134 Uncharacterized protein yadMPutative chaperone–usher fimbrial operon (class γ4); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY240.878SpI2314.8521-00Yn9-17c23/24oUnknown2.525.58
BTUF_ECOLIP37028
btuF

yadT

yadTb0158 JW0154 Vitamin B12-binding proteinPeriplasm Disulfide bridge (183 259) Disulfide bond-containing protein PMID: 25664544PMID: 11790740 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY230.751SpI2210.8439-00Yn8-18c22/23oPeriplasmic10
YAEI_ECOLIP37049
yaeI
b0164 JW5014 Phosphodiesterase yaeI (EC 3.1.4.-)PeriplasmicGN/AMembrane anchoredSECnoyesN470.129CYT0-0.200913-00Yn7-17c22/23oUnknown26.27
YADN_ECOLIP37050
yadN
b0141 JW0137 Uncharacterized fimbrial-like protein yadNPutative chaperone–usher fimbrial operon (class γ4); Fimbrial Subunit. Disulfide bridge (41 86) PMID: 20345943 PMID: 19820722 PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECCUnoyesY240.713SpI2317.9817-00Yn5-15c23/24oExtracellular9.6577.2
YAEF_ECOLIP37056
yaeF

yaeK

yaeKb0193 JW5016 Uncharacterized lipoprotein yaeFOuter Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane LipoproteinSECLOLnoyesY260.176SpII209.80359Pos+2=T00Yn10-21c26/27oUnknown2.550.59
SLP_ECOLIP37194
slp
b3506 JW3474 Outer membrane protein slpLipoprotein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer Membrane Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384 PMID: 9298646PMID: 15174130 PMID: 15911532 PMID: 10806384 PMID: 16079137 PMID: 20932056 PMID: 10806384 PMID: 21541338 PMID: 9298646Outer Membrane LipoproteinISoluble IM FractionCell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY180.153SpII1821.4364Pos+2=S00Yn6-16c21/22oOuterMembrane10
YHJA_ECOLIP37197
yhjA
b3518 JW3486 Probable cytochrome c peroxidase (EC 1.11.1.5)Peripheral inner membrane lipoprotein facing the periplasmic space.By virtue of its homology to the Neisseria protein (Q5F5Z9_neigo1)PMID: 12720546Inner Membrane LipoproteinEN/AMembrane anchoredSECLOLnoyesN290.287SpI284.74738-11="0"i7-28oPeriplasmic9.4421.1
YBCH_ECOLIP37325
ybcH
b0567 JW0556 Primary amine oxidase (EC 1.4.3.21) (2-phenylethylamine oxidase) (Copper amine oxidase) (Tyramine oxidase)PeriplasmicGN/APeriplasmicSECnoyesY210.6SpI2014.6445-10Yn4-15c20/21oCytoplasmicMembrane9.8626.56
MODA_ECOLIP37329
modA
b0763 JW0746 Uncharacterized protein ygeHPeriplasmicPMID: 8576221PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY250.754SpI2418.4352-00Yn8-19c24/25oPeriplasmic1099.47
XYLF_ECOLIP37387
xylF

xylT

xylTb3566 JW3538 D-xylose-binding periplasmic proteinPeriplasmicPMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY240.78SpI2314.4657-00Yn6-17c23/24oPeriplasmic10
MDTE_ECOLIP37636
mdtE

yhiU

yhiUb3513 JW3481 Multidrug resistance protein mdtELipoprotein (experimental).Outer membrane protein related to resistance to ampicillin and tetracycline Proven pignal peptidase II substrate.PMID: 16372265 PMID: 15174130Outer Membrane LipoproteinISoluble IM FractionCell inner membrane | Lipid-anchorInner membrane lipoproteinSECLOLyesyesY260.181SpII2022.544Pos+2=D00Yn7-15c20/21oCytoplasmicMembrane9.9789.6
YHJJ_ECOLIP37648
yhjJ
b3527 JW3495 Protein yhjJ Periplasmic Potential Skp substrate PMID: 19953543 PMID: 9298646 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSKPyesyesY250.722SpI2414.0569-00Yn8-19c24/25oUnknown2.583.47
BCSC_ECOLIP37650
bcsC

yhjL

yhjLb3530 JW5942 Cellulose synthase operon protein CPeriplasmicGN/APeriplasmicSECnoyesY240.51SpI236.58448-00Yn8-18c23/24oUnknown4.72
GUN_ECOLIP37651
bcsZ

bcsC yhjM

bcsC yhjMb3531 JW3499 Endoglucanase (EC 3.2.1.4) (Carboxymethylcellulase) (CMCase) (Cellulase) (Endo-1,4-beta-glucanase)Periplasmic PMID: 10102357 PMID: 11260463 PMID: 21454578 PMID: 24097954PeriplasmicGN/ASecretedPeriplasmic (Experimental)SECnoyesY220.88SpII2212.5942Pos+2=T00Yn6-17c21/22oExtracellular106.23
YHJY_ECOLIP37663
yhjY
b3548 JW5659 Uncharacterized protein yhjYAg43 homologue ; predicted autotransporter. Contains autotransporter beta-domain (IPR005546)PMID: 15590781Outer Membrane b-barrel proteinHN/APeriplasmicSECAutotransporter(T5S)noyesN310.371SpI3011.8549-10Yn14-25c30/31oUnknown79.1
YIAO_ECOLIP37676
yiaO
b3579 JW3551 2,3-diketo-L-gulonate-binding periplasmic protein yiaO (2,3-DKG-binding protein) (Extracytoplasmic solute receptor protein yiaO)PeriplasmPMID: 16385129PeriplasmicGN/APeriplasmPeriplasmicSECnoyesY250.815SpI2415.7433-00Yn6-17c24/25oPeriplasmic1020.37
ENVC_ECOLIP37690
envC

yibP

yibPb3613 JW5646 Uncharacterized protein yibPPeriplasm Periplasm Periplasm Inner Membrane LipoproteinPMID: 12113939 PMID: 15165230 PMID: 19525345 PMID: 8472900PeriplasmicGSoluble IM FractionInner Membrane Lipoprotein (Experimental)SECyesyesY350.862SpI3413.522-10Yn18-29c34/35oOuterMembrane9.9310.62
YIBQ_ECOLIP37691
yibQ
b3614 JW5645 Uncharacterized protein yibQPMID: 19953543PeriplasmicGN/APeriplasmicSECyesyesY240.782SpI2313.9145-10Yn8-18c23/24oUnknown2.514.82
RMLA1_ECOLIP37744
rmlA1

rfbA rmlA

rfbA rmlAb2039 JW2024 Glucose-1-phosphate thymidylyltransferase 1 (G1P-TT 1) (EC 2.7.7.24) (dTDP-glucose pyrophosphorylase 1) (dTDP-glucose synthase 1)PMID: 23138692 PMID: 7537247PeriplasmicGIM (predicted-detected)CytoplasmicSECyesyesN240.125CYT0-0.200913-00Yn7-18c23/24oCytoplasmic9.2663.62
GLTI_ECOLIP37902
gltI

ybeJ yzzK

ybeJ yzzKb0655 JW5092 Glutamate/aspartate periplasmic-binding protein Periplasmic Substrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 8740179 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 19953543 PMID: 8740179 PMID: 22030350 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY230.775SpI2221.5903-00Yn7-17c22/23oPeriplasmic1093.99
YBGD_ECOLIP37909
ybgD
b0719 JW0709 Uncharacterized fimbrial-like protein ybgDPutative chaperone–usher fimbrial operon yeh (class π); Fimbrial Subunit. Disulfide bridge (42 81) PMID: 20345943 PMID: 19820722 PMID: 20345943 PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECCUnoyesY240.878SpI2315.4399-00Yn7-18c23/24oExtracellular9.72
SFMF_ECOLIP38052
sfmF

ybcG

ybcGb0534 JW5072 Fimbrial-like protein sfmFPotential fimbrial sfm operon (class γ1); Fimbrial Subunit. Disulfide bridge (40 80) PMID: 20345943 PMID: 19820722 PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECCUnoyesY210.763SpI2016.3129-00Yn4-15c20/21oExtracellular9.7164.72
TORT_ECOLIP38683
torT

yccH

yccHb0994 JW0979 Periplasmic protein torTPeriplasmic Might be is co-translationally translocated through Sec translocon. PMID: 8576063 The precursor of TorT harbouring hydrophobic signal sequence require SRP and FtsY in addition to SecA for maximal translocation. PMID: 24717922 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024 Disulfide bond-containing protein PMID: 25664544PMID: 15838024 PMID: 8576063 PMID: 24717922 PMID: 15838024 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SRP (exp)SECyesyesY190.789SpI1812.9296-00Yn3-14c18/19oPeriplasmic1012.65
DEGQ_ECOLIP39099
degQ

hhoA

hhoAb3234 JW3203 Protease degQ (EC 3.4.21.-)Periplasm Periplasmic PeriplasmicPMID: 8576051 PMID: 8576052 PMID: 9740056PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY280.555SpI2717.6659-10Yn7-19c27/28oPeriplasmic1066.95
YCHO_ECOLIP39165
ychO

ychP

ychPb1220 JW1211 Uncharacterized protein ychOHomologous to intimin / invasin family (yeej_coli).PeriplasmicGN/APeriplasmCytoplasmicSECyesyesY250.55SpI248.3661-00Yn8-19c24/25oOuterMembrane107.27
ZNUA_ECOLIP39172
znuA

yebL yzzP

yebL yzzPb1857 JW5831 High-affinity zinc uptake system protein znuAPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY270.573SpI2318.3411-00Yn6-17c26/27oPeriplasmic1084.91
ERFK_ECOLIP39176
erfK

yeeG yzzT

yeeG yzzTb1990 JW1968 Probable L,D-transpeptidase ErfK/SrfK (EC 2.-.-.-)Peripheral outer membrane protein facing the periplasm (experimental). PeriplasmicPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. ErfK has been shown to crosslink Braun's lipoprotein (Lpp) to the peptidoglycan. PMID: 9298646PMID: 18498364 PMID: 23832002 PMID: 9298646Peripheral outer membrane protein facing the periplasmF3N/APeriplasmPeriplasmic (Experimental)SECSURAyesyesY220.658SpI2117.0042-00Yn6-16c21/22oUnknown2.511.11
AG43_ECOLIP39180
flu

yeeQ yzzX

yeeQ yzzXb2000 JW1982 Antigen 43 (AG43) (Fluffing protein) [Cleaved into: Antigen 43 alpha chain; Antigen 43 beta chain]Outer membrane protein (experimental). Outer Membrane ss-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (PMID: 15911532, PMID: 12624733, PMID: 10806384). Potential substrate of TAM secretion systemPMID: 22466966. Contains autotransporter beta-domain (IPR005546) PMID: 9298646PMID: 15590781 PMID: 12624733 PMID: 22466966 PMID: 22905239 PMID: 10806384 PMID: 15911532 PMID: 9298646Outer Membrane b-barrel proteinHN/AOuter Membrane β-barrel protein (Experimental)SECAutotransporter(T5S), TAMProphage Integrase (EcoGene)nonoN530.646SpI525.41594-10Yn34-45c52/53oOuterMembrane1032.89
FIMI_ECOLIP39264
fimI
b4315 JW5779 Fimbrin-like protein fimIFim operon (class γ1); Fimbrial Subunit. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. Disulfide bridge (43 83) PMID: 19820722 PMID: 2890081 PMID: 20345943 PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECCUnoyesY200.716SpI1916.0857-00Yn6-13c19/20oExtracellular9.7237.53
ALSB_ECOLIP39265
alsB

yjcX

yjcXb4088 JW4049 D-allose-binding periplasmic protein (ALBP)PeriplasmicPMID: 14499611PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY240.81SpI2318.079-10Yn8-18c23/24oPeriplasmic1053.3
BSMA_ECOLIP39297
bsmA

yjfO

yjfOb4189 JW5743 Lipoprotein BsmA (Biofilm stress and motility protein)Outer membrane protein (experimental).PMID: 20932056Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane LipoproteinSECLOLyesyesY300.447SpII2420.0908Pos+2=S10Yn13-22c27/28oUnknown2.546.79
YTFQ_ECOLIP39325
ytfQ
b4227 JW4186 ABC transporter periplasmic-binding protein ytfQ Periplasmic Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY220.849SpI2121.6548-10Yn5-13c21/22oPeriplasmic1090.28
NANM_ECOLIP39371
nanM

yjhT

yjhTb4310 JW5777 N-acetylneuraminate epimerase (EC 5.1.3.n1) (N-acetylneuraminate mutarotase) (Neu5Ac mutarotase) (Sialic acid epimerase)PeriplasmPMID: 18063573PeriplasmicGN/APeriplasmPeriplasmicSECnoyesY200.747SpI1918.4486-00Yn4-15c19/20oUnknown2.575.93
YGIL_ECOLIP39834
ygiL
b3043 JW3011 Uncharacterized fimbrial-like protein ygiLPutative chaperone–usher fimbrial operon (class π); Unknown function. Disulfide bridge (41 80) PMID: 19820722 PMID: 20345943 PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECCUnoyesY240.867SpI2315.5994-00Yn7-18c23/24oExtracellular9.7292.29
NLPE_ECOLIP40710
nlpE

cutF

cutFb0192 JW0188 Lipoprotein nlpE (Copper homeostasis protein cutF)Lipoprotein (experimental) Outer membrane protein (experimental). Outer membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 7635807PMID: 15174130 PMID: 20932056 PMID: 7635807Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane Lipoprotein(experimental)SECLOLyesyesY360.226SpII2012.8918Pos+2=N00Yn6-17c35/36oOuterMembrane10112.95
YCBF_ECOLIP40876
ycbF
b0944 JW5124 Uncharacterized fimbrial chaperone ycbFPotential fimbrial ycb operon (class γ1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmPeriplasmicfimbriaeSECSURAnoyesN270.646SpI269.39817-10Yn8-19c26/27oPeriplasmic9.9919.42
MLTB_ECOLIP41052
mltB
b2701 JW2671 Membrane-bound lytic murein transglycosylase B (EC 4.2.2.n1) (35 kDa soluble lytic transglycosylase) (Murein hydrolase B) (Slt35)Lipoprotein (experimental) Outer membrane protein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinISoluble IM FractionCell outer membrane | Lipid-anchor | Periplasmic sideOuter membrane Lipoprotein (Experimental)SECLOLyesyesY240.231SpII1824.349Pos+2=S00Yn7-17c21/22oCytoplasmicMembrane9.8227.25
PAT_ECOLIP42588
patA

ygjG

ygjGb3073 JW5510 Putrescine aminotransferase (EC 2.6.1.82) (Putrescine--2-oxoglutaric acid transaminase) (PAT) (PATase)PeriplasmicGN/APeriplasmicSECSURAyesyesN180.23SpI172.36785-00Yn4-12c17/18oCytoplasmic9.9752.76
YGJJ_ECOLIP42591
ygjJ
b3079 JW3050 Uncharacterized protein ygjJPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAyesyesY220.252SpI247.25386-00Yn3-14c19/20oUnknown2.531.06
YGJK_ECOLIP42592
ygjK
b3080 JW3051 Uncharacterized protein ygjKPeriplasmicGN/APeriplasmicSECnoyesY230.898SpI2221.1996-00Yn5-16c25/26oPeriplasmic9.8422.19
YRAH_ECOLIP42913
yraH
b3142 JW3111 Uncharacterized fimbrial-like protein yraHPotential fimbrial yra operon (class γ1); Fimbrial Subunit. Disulfide bridge (38 78) PMID: 19820722 PMID: 20345943 PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECCUnoyesY230.673SpI2211.7644-00Yn7-17c22/23oExtracellular9.72
YRAI_ECOLIP42914
yraI
b3143 JW3112 Uncharacterized fimbrial chaperone yraIPotential fimbrial yra operon (class γ1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Might be is co-translationally translocated through Sec translocon. Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024PMID: 18498364 PMID: 20345943 PMID: 15838024 PMID: 15838024PeriplasmicGN/APeriplasmPeriplasmicfimbriaeSRP (exp)SECSURAnoyesY240.709SpI2314.1781-10Yn7-18c23/24oPeriplasmic1056.42
YRAJ_ECOLIP42915
yraJ
b3144 JW3113 Uncharacterized outer membrane usher protein yraJPotential fimbrial yra operon (class γ1); Usher. Disulfide bridge (815 837) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel proteinfimbriaeSECBAMnoyesN410.51SpI409.33083-00="0"iOuterMembrane106.52
YRAK_ECOLIP43319
yraK
b3145 JW3114 Uncharacterized fimbrial-like protein yraKCell surface appendagePotential fimbrial yra operon (class γ1); Potential tip-adhesin. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 20345943PMID: 19820722 PMID: 20345943 PMID: 18498364 PMID: 20345943PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECSURACUnoyesY210.726SpI2018.7753-00Yn4-15c20/21oUnknown278.18
YCAL_ECOLIP43674
ycaL
b0909 JW0892 Uncharacterized metalloprotease ycaL (EC 3.4.24.-)Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLyesyesN260.214SpII1926.2238Pos+2=Q00Yn6-17c25/26oUnknown2.524.37
YHCD_ECOLIP45420
yhcD
b3216 JW3183 Uncharacterized outer membrane usher protein yehBPotential fimbrial yhc operon (class β); Uknown function. Disulfide bridge (769 792) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel proteinfimbriaeSECBAMnoyesY220.809SpI2110.0887-00Yn5-16c21/22oOuterMembrane10
LPOA_ECOLIP45464
lpoA

yraM

yraMb3147 JW3116 Uncharacterized protein yraMPeriplasm. Cell outer membrane Cell outer membrane Outer membrane protein (experimental). The two OM lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Disulfide bond-containing protein PMID: 25664544PMID: 15911532 PMID: 21183073 PMID: 21183074 PMID: 20932056 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionMembrane LipoproteinSECLOLnoyesY260.162SpII2612.6937Pos+2=G00Yn14-27c45/46oCytoplasmicMembrane9.82105.05
YFAL_ECOLIP45508
yfaL

yfaF yfaJ yfaK

yfaF yfaJ yfaKb2233 JW2227 Uncharacterized protein yfaLAg43 homologue; predicted autotransporter. Contains autotransporter beta-domain (IPR005546)PMID: 15590781Outer Membrane b-barrel proteinHN/APeriplasmicSECAutotransporter(T5S)yesyesY290.358SpI2813.6585-00Yn11-22c29/30oOuterMembrane9.8352.49
FKBA_ECOLIP45523
fkpA

yzzS

yzzSb3347 JW3309 FKBP-type peptidyl-prolyl cis-trans isomerase fkpA (PPIase) (EC 5.2.1.8) (Rotamase)Periplasmic SecB substrate. PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350PMID: 16352602 PMID: 9298646 PMID: 22030350PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECBSECyesyesY260.701SpI2514.7593-00Yn7-18c25/26oPeriplasmic10
YFEN_ECOLIP45564
yfeN
b2408 JW2399 Uncharacterized protein ydeUOuter Membrane b-barrel proteinHN/AOuter Membrane β-barrel proteinSECBAMnoyesY230.452SpI2212.5667-00Yn5-16c22/23oUnknown26.33
AIS_ECOLIP45565
ais

pmrG

pmrGb2252 JW2246 Lipopolysaccharide core heptose(II)-phosphate phosphatase (EC 3.1.3.-) (Polymyxin resistance protein pmrG)Periplasmic protein by virtue of its homology with the well characterized Salmonella homologue PmrGPMID: 16803591. Disulfide bond-containing protein PMID: 25664544PMID: 16803591 PMID: 25664544PeriplasmicGN/APeriplasmMembrane anchoredSECyesyesN320.351SpI319.81523-10Yn16-27c31/32oUnknown2.550.08
GSPD_ECOLIP45758
gspD

yheF

yheFb3325 JW5707 Probable general secretion pathway protein DOuter membrane b-barel Outer membrane PeriplasmicPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Homolog to type two secretion system proteins PulD. Potential outer membrane b-barel protein since it is homolog to pulD major component of type two secretion system. GspD is the outer membrane secretin of type II secretion system (T2SS) which forms a multimeric pore for translocation of secreted proteins. GspD and the inner membrane protein GspC interact with each other via periplasmic domains (observed in the crystal structure). PMID: 21931548 PMID: 11266368PMID: 18498364 PMID: 14966662 PMID: 11118204 PMID: 21931548 PMID: 11266368Outer Membrane b-barrel proteinHN/ACell outer membranePeriplasmic (Experimental)SECSURABAMnoyesY240.553SpI2314.273-00Yn7-16c23/24oOuterMembrane1034.93
GSPJ_ECOLIP45761
gspJ

yheI

yheIb3331 JW3293 Probable general secretion pathway protein JIntegral inner membrane. PeriplasmicPotential component of type II secretion system. GspJ is one of four low abundance pseudopillins together with GspI, H and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368PMID: 14966662 PMID: 11118204 PMID: 18241884 PMID: 23006128 PMID: 21890895 PMID: 11266368PeriplasmicGN/APeriplasmic (Experimental)SECT2SnoyesN280.304SpI342.3055-11="0"i7-31oCytoplasmicMembrane9.82
GSPK_ECOLIP45762
gspK

yheJ

yheJb3332 JW3294 Probable general secretion pathway protein KIntegral inner membrane. PeriplasmicPotential component of type II secretion system. GspK is one of four low abundance pseudopillins together with GspI, J and H. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368PMID: 14966662 PMID: 11118204 PMID: 18241884 PMID: 23006128 PMID: 21890895 PMID: 11266368PeriplasmicGN/ACell inner membranePeriplasmic (Experimental)SECT2SnoyesN250.537SpI248.69449-10Yn8-19c24/25oCytoplasmicMembrane9.9730.51
YHDW_ECOLIP45766
yhdW
b3268 JW3236 Putative amino-acid ABC transporter-binding protein yhdW Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGSoluble IM FractionCell inner membraneCytoplasmicSECpseudogene (Uniprot) nonoY250.628SpI2420.0416-00Yn6-17c24/25oPeriplasmic1089.71
YBGF_ECOLIP45955
ybgF
b0742 JW0732 Uncharacterized protein YbgF PeriplasmicSecB substrate. The N-terminal coiled coil of YbgFvforms a stable trimer and controls the oligomeric status of YbgF.The stable YbgF trimer undergoes a marked change in oligomeric state on binding TolA, forming a one-to-one complex with the Tol protein. PMID: 11703658PMID: 16352602 PMID: 20816983 PMID: 11703658PeriplasmicGN/APeriplasmic (Experimental)SECBSECyesyesY270.495SpI2613.974-00Yn9-20c26/27oPeriplasmic9.8419.59
YBHC_ECOLIP46130
ybhC
b0772 JW0755 Putative acyl-CoA thioester hydrolase ybhC (EC 3.1.2.-)Lipoprotein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) PMID: 10806384 Disulfide bridge (185 197) PMID: 19452549PMID: 15174130 PMID: 15911532 PMID: 10806384 PMID: 20932056 PMID: 10806384 PMID: 19452549Outer Membrane LipoproteinISoluble IM FractionCell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY240.274SpII2124.9976Pos+2=S00Yn9-19c24/25oOuterMembrane9.9371.31
YHDP_ECOLIP46474
yhdP

yhdQ yhdR

yhdQ yhdRb4472 JW5542 Uncharacterized protein yhdPOuter Membrane b-barrel proteinHN/ACytoplasmicSECBAMpseudogene (Ochman & Davalos, 2006)yesyesN300.25SpI295.14802-10Yn7-22c29/30oCytoplasmicMembrane9.86
AMO_ECOLIP46883
tynA

maoA

maoAb1386 JW1381 Glutamate/aspartate transport ATP-binding protein gltL Periplasmic Potential Skp substrate PMID: 19953543 PMID: 8631685PMID: 19953543 PMID: 8631685PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSKPnoyesY310.714SpI3012.7601-00Yn13-24c30/31oPeriplasmic1097.33
YPJA_ECOLIP52143
ypjA
b2647 JW5422 Uncharacterized outer membrane usher protein yhcDAg43 homologue; predicted autotransporter. Contains autotransporter beta-domain (IPR005546). Potential Srp-dependent autotransporter. Homologous to hemoglobin-binding protease hbp. Hbp is the only known autotransporter that is secreted through the integral membrane in a Srp-dependent manner.PMID: 15590781 PMID: 22905239 PMID: 12466262Outer Membrane b-barrel proteinHN/ACell outer membrane | Peripheral membrane proteinOuter Membrane β-barrel proteinSRPSECAutotransporter(T5S)noyesY300.688SpI2911.7048-10Yn13-24c29/30oUnknown5.87
EMRK_ECOLIP52599
emrK
b2368 JW2365 Multidrug resistance protein KPeriplasmicPMID: 11914367PeriplasmicGN/ACell inner membrane | Single-pass membrane proteinPeriplasmic (Experimental)SECyesyesN340.579SpI3315.7518-10Yn17-28c33/34oCytoplasmicMembrane9.8238.88
LOLA_ECOLIP61316
lolA

lplA yzzV

lplA yzzVb0891 JW0874 Outer-membrane lipoprotein carrier protein (P20)Periplasmic PeriplasmicPMID: 15276320 PMID: 7628437 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY220.602SpI2120.5659-00Yn4-15c21/22oPeriplasmic1070.61
LOLB_ECOLIP61320
lolB

hemM ychC

hemM ychCb1209 JW1200 Outer-membrane lipoprotein lolBLipoprotein (experimental). Outer membrane protein (experimental). Outer mebrane protein (experimental). Outer membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002) Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 16091355PMID: 15276320 PMID: 15174130 PMID: 12488465 PMID: 15911532 PMID: 12624733 PMID: 20932056 PMID: 21541338 PMID: 16091355Outer Membrane LipoproteinISoluble IM FractionCell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY240.169SpII2113.4863Pos+2=S00Yn11-22c27/28oPeriplasmic9.8385.4
SECM_ECOLIP62395
secM

srrA yacA

srrA yacAb0097 JW5007 Secretion monitorPeriplasmicSecM regulates secA expression by translational coupling of the secM secA operon. Fusion of SecM with alkaline phosphatase activity exhibits substantial activity in the periplasm. SecM periplasmic form is rapidly degraded. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 11597451PMID: 18498364 PMID: 1834634 PMID: 11597451Cytoplasmic, PeriplasmicA, GN/ACytoplasm cytosolPeriplasmPeriplasmic (Experimental)SECSURAyesyesY380.527SpI3711.5151-10Yn20-31c37/38oCytoplasmic10
YDDW_ECOLIP64426
yddW
b1491 JW1486 UPF0748 lipoprotein yddWLipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY360.168SpII2712.5186Pos+2=K00Yn16-26c30/31oUnknown262.01
YDCL_ECOLIP64451
ydcL
b1431 JW1427 Uncharacterized lipoprotein ydcLLipoprotein (experimental). Outer membrane protein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY250.223SpII2019.8371Pos+2=A00Yn9-18c23/24oUnknown2
YRAP_ECOLIP64596
yraP
b3150 JW3119 Uncharacterized protein yraPPeripheral inner membrane protein facing the periplasm (potential). Outer membrane Lipoprotein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Lipoprotein (experimental).Contains 2 BON domains IPR007055. BON domains are putative membrane-binding domains PMID: 12878000.The BON domain is typically ~60 residues long and has an alpha/beta predicted fold. The domain architecture of two BON domains alone suggests that these domains contact the surfaces of phospholipids, with each domain contacting a membrane. These are found in a family of osmotic shock protection proteins (e.g. P27291). It is also found in some Secretins and a group of potential haemolysins. Its likely function is attachment to phospholipid membranes. Is homologous to the OsmY_Ecoli protein. There is a conserved glycine residue and several hydrophobic regions. This pattern of conservation is more suggestive of a binding or structural function rather than a catalytic function. Most proteobacteria seem to possess one or two BON-containing proteins, typically of the OsmY-type proteins. Outside of this group the distribution is more disparate. OsmY protein is a 20 kDa outer membrane or periplasmic protein that is expressed in response to a variety of stress conditions. In particular, helping to provide protection against osmotic shock. One hypothesis is that OsmYPrevents shrinkage of the cytoplasmic compartment by contacting the phospholipid interfaces surrounding the periplasmic space. Proven pignal peptidase II substrate PMID: 15174130. Detected in the outer membrane fraction, with mass spectrometric analysis coupled by SDS gel electrophoresisPMID: 20932056. Outer membrane protein determined by LC-MS PMID: 12488465. DacB, DcrB, HybA, and YraP were assigned to either the inner or outer membrane. These apparent differences could be reasonably accommodated if these proteins were peripherally associated with the side of either the inner or outer membrane that faces the periplasmic space PMID: 15911532. PMID: 15174130PMID: 12878000 PMID: 15174130 PMID: 12488465 PMID: 15911532 PMID: 20932056 PMID: 17904518 PMID: 15968066Outer Membrane LipoproteinIN/APeriplasmOuter membrane Lipoprotein(experimental)SECLOLyesyesY230.327SpII1813.0401Pos+2=V10Yn3-16c21/22oPeriplasmic9.7695.84
MLAD_ECOLIP64604
mlaD

yrbD

yrbDb3193 JW3160 Probable phospholipid ABC transporter-binding protein mlaDPeriplasmicGSoluble IM FractionCell inner membrane | Single-pass type II membrane protein | Periplasmic sidePeriplasmicSECyesyesN290.187SpI287.17952-10Yn8-23c28/29oUnknown2.560.32
YGDI_ECOLIP65292
ygdI
b2809 JW5448 Uncharacterized lipoprotein ygdI Outer membrane LipoproteinOuter membrane protein determined by LC-MS (Gevaert et al 2002) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 15174130PMID: 12488465 PMID: 21541338 PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY220.339SpII1921.6734Pos+2=S10Yn6-17c22/23oUnknown2.5119.58
BEPA_ECOLIP66948
yfgC
b2494 JW2479 Beta-barrel assembly-enhancing protease Periplasm. BepA maintains the integrity of OM both by promoting assembly of OMPs and by proteolytically eliminating OMPs when their correct assembly was compromised. BepA is a metalloprotease that cleaves its targets preferentially between Phe-Phe residues. Potential Skp substrate PMID: 19953543PMID: 24003122 PMID: 22491786 PMID: 19953543 PMID: 22901060 PMID: 24003122PeriplasmicGN/APeriplasmicSECSKPyesyesY280.636SpI2715.2429-00Yn9-19c27/28oUnknown2.510.5
YNFC_ECOLIP67553
ynfC
b1585 JW5258 UPF0257 lipoprotein ynfCLipoprotein (experimental). Proven pignal peptidase II substrate.PMID: 15174130Inner Membrane LipoproteinEN/ACell membrane | Lipid-anchorInner membrane lipoproteinSECLOLyesyesN210.178SpII1614.4125Pos+2=D00Yn5-14c19/20oCytoplasmic8.96
RCSF_ECOLIP69411
rcsF
b0196 JW0192 Protein rcsFOuter membrane Lipoprotein (experimental). Cell outer membrane Cell outer membrane Outer membrane protein (experimental). Proven pignal peptidase II substrate. Identified DsbA substrate PMID: 19953543 PMID: 15174130 Disulfide bridge (74 118;109 124) Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 16740933 PMID: 23813676 PMID: 20932056 PMID: 19953543 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionCell outer membraneOuter membrane Lipoprotein (Experimental)SECDSBALOLyesyesY230.182SpII1513.2891Pos+2=S00Yn3-13c21/22oOuterMembrane1081.91
PGAA_ECOLIP69434
pgaA

ycdS

ycdSb1024 JW1010 Poly-beta-1,6-N-acetyl-D-glucosamine export protein (PGA export protein) (Poly-beta-1,6-GlcNAc export protein)Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel proteinSECBAMnoyesY330.331SpI3212.415-00Yn18-26c32/33oUnknown2.56.5
LPP_ECOLIP69776
lpp

mlpA mulI

mlpA mulIb1677 JW1667 Major outer membrane lipoprotein Lpp (Braun lipoprotein) (Murein-lipoprotein)Lipoprotein (experimental). Outer membrane protein (experimental). Cell outer membrane Cell outer membrane Outer membrane LipoproteinTrigger factor-sensitive aggregation. Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005). Covalently attached to the peptidoglycan cell wall by the ε-amino group of its C-terminal Lys residue; stabilizes the bacterial envelope. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 4575979PMID: 15174130 PMID: 19737520 PMID: 15911532 PMID: 21219470 PMID: 3013869 PMID: 16079137 PMID: 21541338 PMID: 4575979Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular spaceI, F4Soluble IM FractionCell outer membrane | Lipid-anchorCell outer membrane | Peptidoglycan-anchorOuter membrane Lipoprotein (Experimental)TFSECLOLyesyesY260.325SpII2026.7873Pos+2=S00Yn6-17c25/26oOuterMembrane1058.22
SFMH_ECOLIP75715
sfmH
b0533 JW5071 Protein sfmHCell surface appendagePotential fimbrial sfm operon (class γ1); Potential tip-adhesin. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 20345943PMID: 19820722 PMID: 20345943 PMID: 18498364 PMID: 20345943PeriplasmicGN/AFimbriumCytoplasmicfimbriaeSECSURACUnoyesY190.186SpI246.26896-00Yn2-9c14/15oUnknown217.07
YBFM_ECOLIP75733
ybfM

ybfM

ybfMb0681 JW0667 Uncharacterized protein ybfMOuter Membrane b-barrel proteinHN/AOuter Membrane β-barrel proteinSECBAMnoyesY330.272SpI3212.9387-00Yn10-20c32/33oUnknown2.51.4
YBFL_ECOLIP75741
ybfL
b0705 JW0695 Putative protein ybfL (H repeat-associated protein in rhsC-phrB intergenic region) (ORF-H2)No transmembrane helix is predicted. Weak hydrophobic and non cytoplasmic regions predicted by Phobius.PeriplasmicGIM (predicted-detected)Cell membrane | Lipid-anchorCytoplasmicSECTransposase, Rhs ElementnonoN420.157CYT0-0.200913-00Yn26-38c43/44oCytoplasmic8.9616.36
YBGO_ECOLIP75748
ybgO
b0716 JW5098 Uncharacterized protein ybgOPutative chaperone–usher fimbrial operon yeh (class π); Unkown function. Disulfide bond-containing protein PMID: 25664544PMID: 20345943 PMID: 25664544PeriplasmicGN/APeriplasmicfimbriaeSECnoyesN240.359SpI237.76951-00Yn7-18c23/24oCytoplasmic8.9653.02
YBGP_ECOLIP75749
ybgP
b0717 JW0707 Uncharacterized fimbrial chaperone ybgPPutative chaperone–usher fimbrial operon yeh (class π); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364 PMID: 20345943PeriplasmicGN/APeriplasmPeriplasmicfimbriaeSECSURAnoyesY210.795SpI205.41341-00Yn6-16c20/21oPeriplasmic1019.01
YBGQ_ECOLIP75750
ybgQ
b0718 JW5099 Uncharacterized outer membrane usher protein ybgQPutative chaperone–usher fimbrial operon yeh (class π); Usher. Disulfide bridge (795 814) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel proteinfimbriaeSECBAMnoyesY220.84SpI218.29107-00Yn6-16c21/22oOuterMembrane1010.92
FIU_ECOLIP75780
fiu

ybiL

ybiLb0805 JW0790 Catecholate siderophore receptor fiu (Ferric iron uptake protein) (TonB-dependent receptor fiu)Outer Membrane β-barrel protein (experimental). Outer membrane protein (experimental). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003)','Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 10806384 Disulfide bond-containing protein PMID: 25664544PMID: 10806384 PMID: 20932056 PMID: 19953543 PMID: 25664544Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane β-barrel protein (Experimental)SECSKPBAMyesyesY340.525SpI3311.8291-10Yn14-25c33/34oOuterMembrane1010.6
GSIB_ECOLIP75797
gsiB

yliB

yliBb0830 JW5111 Glutathione-binding protein gsiB Periplasmic Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 15911532PMID: 18498364 PMID: 15911532PeriplasmicGN/APeriplasm Periplasmic(experimental)SECSURAyesyesY270.582SpI2615.0769-00Yn10-21c26/27oPeriplasmic1040.27
YLII_ECOLIP75804
yliI
b0837 JW0821 Soluble aldose sugar dehydrogenase yliI (Asd) (EC 1.1.5.-) Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAnoyesY210.629SpI209.24571-00Yn5-15c20/21oCytoplasmicMembrane9.8621.96
YBJP_ECOLIP75818
ybjP
b0865 JW0849 Uncharacterized lipoprotein ybjPLipoprotein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental). Outer membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Identified DsbA substrate PMID: 19953543 PMID: 10806384 Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 15911532 PMID: 20932056 PMID: 21541338 PMID: 19953543 PMID: 10806384 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionCell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECDSBALOLnoyesY280.445SpII1810.6734Pos+2=T00Yn9-19c24/25oUnknown269.59
AMID_ECOLIP75820
amiD

ybjR

ybjRb0867 JW0851 N-acetylmuramoyl-L-alanine amidase AmiD (EC 3.5.1.28)Lipoprotein (experimental).Proven pignal peptidase II substrate.PMID: 15174130Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane LipoproteinSECLOLyesyesY210.182SpII1618.0923Pos+2=A00Yn4-14c19/20oUnknown6.4918.74
SSUA_ECOLIP75853
ssuA

ycbO

ycbOb0936 JW0919 Putative aliphatic sulfonates-binding proteinPeriplasmicPMID: 10781534PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY220.876SpI2114.9607-00Yn7-18c22/23oUnknown2.576.36
YCBQ_ECOLIP75855
elfA

ycbQ

ycbQb0938 JW5122 Uncharacterized fimbrial-like protein ycbQPotential fimbrial ycb operon (class γ1); Fimbrial Subunit.PMID: 20345943 PMID: 19820722PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECCUnoyesY220.807SpI2123.0184-00Yn5-16c21/22oExtracellular1085.68
YCBR_ECOLIP75856
elfD

ycbR

ycbRb0939 JW0922 Uncharacterized fimbrial chaperone ycbRPotential fimbrial ycb operon (class γ1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmPeriplasmicfimbriaeSECSURAyesyesY270.835SpI2618.1825-00Yn10-21c26/27oUnknown6.5829.44
YCBS_ECOLIP75857
elfC

ycbS

ycbSb0940 JW0923 Uncharacterized outer membrane usher protein ycbSPotential fimbrial ycb operon (class γ1); Usher.PMID: 20345943Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel proteinfimbriaeSECBAMyesyesN360.312SpI356.8393-10Yn19-30c35/36oOuterMembrane107.02
YCBT_ECOLIP75858
elfG

ycbT

ycbTb0941 JW0924 Uncharacterized fimbrial-like protein ycbTInner membrane. Cell surface appendagePotential fimbrial ycb operon (class γ1); Potential yip-adhesin. PMID: 20345943PMID: 19820722 PMID: 20345943 PMID: 21890895 PMID: 20345943PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECCUnoyesY310.334SpI305.91464-10Yn15-25c30/31oExtracellular9.7132.13
YCBU_ECOLIP75859
ycbU
b0942 JW0925 Uncharacterized fimbrial-like protein ycbUPotential fimbrial ycb operon (class γ1); Fimbrial Subunit. Ycb operon is homolog to fim operon (ycbv is fimI homolog).PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECCUnoyesY250.653SpI245.70567-10Yn6-17c24/25oExtracellular9.7141.22
YCBV_ECOLIP75860
ycbV
b0943 JW5123 Uncharacterized fimbrial-like protein ycbVPotential fimbrial ycb operon (class γ1); Fimbrial Subunit. Ycb operon is homolog to fim operon (ycbv is fimI homolog).PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECCUnoyesN230.301SpI225.04607-00Yn6-17c22/23oUnknown247.4
GFCD_ECOLIP75882
gfcD

ymcA

ymcAb0984 JW0967 Uncharacterized lipoprotein gfcD (Group 4 capsule protein D homolog)PeriplasmicGN/ACell membrane | Lipid-anchorPeriplasmicSECyesyesY220.783SpI2117.8352-00Yn7-15c21/22oOuterMembrane9.52
GFCB_ECOLIP75884
gfcB

ymcC

ymcCb0986 JW0969 Uncharacterized lipoprotein gfcB (Group 4 capsule protein B homolog)Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY200.315SpII1511.1657Pos+2=T00Yn4-14c19/20oCytoplasmicMembrane9.8237.47
PGAB_ECOLIP75906
pgaB

ycdR

ycdRb1023 JW5142 Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase (PGA N-deacetylase) (Poly-beta-1,6-GlcNAc N-deacetylase) (EC 3.5.1.-)Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchor | Periplasmic sideOuter membrane Lipoprotein (Experimental)SECLOLnoyesN260.161SpII2014.5441Pos+2=I00Yn9-20c25/26oPeriplasmic9.8315.18
YCFS_ECOLIP75954
ycfS
b1113 JW5820 Probable L,D-transpeptidase YcfS (EC 2.-.-.-)Peripheral outer membrane protein facing the periplasm (experimental).Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. YcfS has been shown to crosslink Braun's lipoprotein (Lpp) to the peptidoglycan.PMID: 18498364 PMID: 23832002Peripheral outer membrane protein facing the periplasmF3N/APeriplasmPeriplasmicSECSURAyesyesY290.319SpI2814.2493-10Yn11-24c28/29oUnknown2.563.09
YCJN_ECOLIP76042
ycjN
b1310 JW1303 Putative ABC transporter periplasmic-binding protein ycjNLipoprotein (experimental).Phobius prediction hydrophobic region around residue 400 with transmembrane probability equal to 0.8. Minor prediction of weak transmembrane region in the same region by TMHMM . Otherwise no obvious signals. Homologous to P28904 (TREC_ECOLI) Trehalose-6-phosphate hydrolase that is totally soluble and cytoplasmic Wikipedia classifies Categories: Transferases | EC 2.4.1 | Peripheral membrane proteins. In Streptococcus Jaecalis it is not found associated with the membrane. Proven pignal peptidase II substrate. PMID: 15174130PMID: 13859056 PMID: 15660210 PMID: 15174130Outer Membrane LipoproteinIN/APeriplasmOuter membrane Lipoprotein (Experimental)SECLOLnoyesN200.189SpII2013.8019Pos+2=K00Yn6-17c21/22oUnknown2.566.62
OMPG_ECOLIP76045
ompG
b1319 JW1312 Outer membrane protein GOuter membrane (experimental) Proteoliposome swelling assays showed that OmpG channels were much larger than those of the OmpF and OmpC porins, with an estimated limited diameter of about 2 nm. PMID: 9721282 Potential Skp substrate PMID: 19953543 PMID: 9721282PMID: 9721282 PMID: 19953543Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECSKPBAMnoyesY200.465SpI2114.867-00Yn4-14c19/20oOuterMembrane1054.94
YDCS_ECOLIP76108
ydcS
b1440 JW1435 Putative ABC transporter periplasmic-binding protein ydcS Periplasmic Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544PMID: 15911532 PMID: 22030350 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY230.836SpI2217.8592-00Yn10-18c22/23oPeriplasmic1016.45
YNCD_ECOLIP76115
yncD
b1451 JW1446 Probable tonB-dependent receptor yncDOuter membrane protein (experimental). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Potential Skp substrate PMID: 19953543PMID: 12624733 PMID: 20932056 PMID: 19953543Outer Membrane b-barrel proteinHN/ACell outer membrane | Peripheral membrane proteinOuter Membrane β-barrel proteinSECSKPBAMnoyesY240.888SpI2312.8703-00Yn10-18c23/24oOuterMembrane102.77
YNCE_ECOLIP76116
yncE
b1452 JW1447 Uncharacterized protein YncESecB substrate.PMID: 16352602PeriplasmicGN/APeriplasmicSECBSECnoyesY310.794SpI3016.4204-00Yn15-26c30/31oUnknown2.564.97
DDPA_ECOLIP76128
ddpA

yddS

yddSb1487 JW5240 Probable D,D-dipeptide-binding periplasmic protein ddpAPeriplasmicPMID: 11121068PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY260.839SpI2519.0002-00Yn10-17c25/26oPeriplasmic1061.68
LSRB_ECOLIP76142
lsrB

yneA

yneAb1516 JW1509 Autoinducer 2-binding protein lsrB (AI-2-binding protein lsrB)PeriplasmicPMID: 15601708PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY270.845SpI2621.9126-00Yn9-20c26/27oPeriplasmic1075.63
LYSQ_ECOLIP76159
arrQ

ydfQ

ydfQb1554 JW1546 Probable lysozyme from lambdoid prophage Qin (EC 3.2.1.17) (Endolysin) (Lysis protein) (Muramidase)Belongs to the glycosyl hydrolase 24 family. Essential for lysis of bacterial cell wall, by showing cell wall hydrolyzing activity.PeriplasmicGN/AMembrane anchoredSECProphage Integrase (EcoGene)nonoY240.219SpI248.4271-10Yn8-19c24/25oUnknown2.582.07
YNFB_ECOLIP76170
ynfB
b1583 JW1575 UPF0482 protein ynfBOuter membrane protein (experimental). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Disulfide bond-containing protein PMID: 25664544PMID: 15911532 PMID: 25664544Peripheral outer membrane protein facing the periplasmF3N/APeriplasmicSECyesyesY290.87SpI2819.5483-00Yn9-20c28/29oUnknown2.549.16
YDGD_ECOLIP76176
ydgD
b1598 JW1590 Uncharacterized serine protease ydgD (EC 3.4.21.-)PeriplasmicGN/APeriplasmicSECyesyesY220.691SpI2115.015-00Yn3-14c21/22oUnknown2.528.71
YDGH_ECOLIP76177
ydgH
b1604 JW1596 Protein ydgHPeriplasmicGN/APeriplasmicSECyesyesY230.805SpI2222.3224-00Yn7-18c22/23oUnknown2.513.19
YNHG_ECOLIP76193
ynhG
b1678 JW1668 Probable L,D-transpeptidase YnhG (EC 2.-.-.-)Peripheral outer membrane protein facing the periplasm (experimental).Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. YnhG forms direct meso- diaminopimelate (DAP-DAP, or 3-3) crosslinks within the peptidoglycan.PMID: 18498364 PMID: 23832002Peripheral outer membrane protein facing the periplasmF3N/APeriplasmPeriplasmicSECSURAyesyesY240.48SpI2315.3547-00Yn4-15c23/24oPeriplasmic9.8422.67
YNJB_ECOLIP76223
ynjB
b1754 JW5284 Protein ynjB Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAnoyesY210.688SpI2011.9034-00Yn4-16c20/21oUnknown2.570.03
YEDS_ECOLIP76335
yedS
b4496 JW5319/JW1948/JW1949 b1964/b1965/b1966Putative outer membrane protein yedSOuter Membrane b-barrel proteinHN/ACell inner membrane | Multi-pass membrane proteinCytoplasmicSECBAMpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)yesnoY220.864SpI2122.1485-00Yn5-16c21/22oOuterMembrane1018.11
HIUH_ECOLIP76341
hiuH

yedX

yedXb1970 JW1953 5-hydroxyisourate hydrolase (HIU hydrolase) (HIUHase) (EC 3.5.2.17) (Transthyretin-like protein) (TLP) (Transthyretin-related protein) (TRP)PeriplasmPMID: 12542701PeriplasmicGN/APeriplasmPeriplasmicSECyesyesY240.79SpI2318.1944-00Yn6-17c23/24oUnknown2.578.26
ZINT_ECOLIP76344
zinT

yodA

yodAb1973 JW1956 Metal-binding protein yodA (Cadmium-induced protein yodA)Cytoplasm, Periplasm Periplasmic After 45 min of cadmium exposure the YodA protein was primarily detected in the cytoplasmic fraction but was later (150 min) found in both the cytoplasmic and periplasmic compartments. PMID: 9579078 Disulfide bond-containing protein PMID: 25664544PMID: 12480884 PMID: 9579078 PMID: 25664544PeriplasmicGN/APeriplasmic (Experimental)SECyesyesY240.683SpI2312.2997-00Yn8-18c23/24oUnknown2.5
YFAP_ECOLIP76462
yfaP
b2225 JW2219 Uncharacterized protein yfaP Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAyesyesY200.599SpI1913.0156-00Yn4-14c19/20oUnknown2107.84
YFAQ_ECOLIP76463
yfaQ
b2226 JW2220 Uncharacterized protein yfaQ Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAnoyesY200.66SpI198.15864-00Yn6-15c19/20oUnknown29.28
YEEJ_ECOLIP76347
yeeJ
b1978 JW5833 Uncharacterized protein yeeJPeripheral inner membrane protein facing the cytoplasm Cytplasmic transciption factor that shuttles from chromosome to the membranes as a peripheral protein on the PtsG transporter. Specifically it binds to the unphosphorylated, tRNAs port-mediating form of the EIIBCGl subunit. PMID: 15063852Outer Membrane b-barrel proteinHN/ACytoplasmicSECBAMnoyesN520.258SpI451.97486-00Yn27-39c51/52oOuterMembrane9.95
YFAS_ECOLIP76464
yfaS

yfaR

yfaRb4500 JW2221/JW2222 b2227/b2228Putative UPF0192 protein yfaS Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGSoluble IM FractionPeriplasmicSECSURApseudogene (Ochman & Davalos, 2006)noyesY390.71SpI3814.0209-00Yn20-31c38/39oUnknown4.7281.71
YFAZ_ECOLIP76471
yfaZ
b2250 JW5371 Uncharacterized protein yfaZOuter membrane protein (experimental).PMID: 20932056Outer Membrane b-barrel proteinHN/AOuter Membrane β-barrel proteinSECBAMnoyesY220.713SpI2119.9632-00Yn4-15c21/22oUnknown2.578.05
YFBK_ECOLIP76481
yfbK
b2270 JW2265 UDP-galactopyranose mutase (EC 5.4.99.9)Inner Membrane LipoproteinEN/AMembrane LipoproteinSECLOLnoyesN240.119SpII1827.352Pos+2=G00Yn6-16c21/22oUnknown249.45
YFCP_ECOLIP76499
yfcP
b2333 JW2330 Uncharacterized fimbrial-like protein yfcPPutative chaperone–usher fimbrial operon yfc (class π); Fimbrial Subunit. Disulfide bridge (43 83) PMID: 19820722 PMID: 20345943 PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECCUyesyesY280.79SpI2714.214-10Yn8-19c27/28oUnknown2.5
MLAA_ECOLIP76506
mlaA

vacJ

vacJb2346 JW2343 Probable phospholipid-binding lipoprotein mlaAOuter membrane Lipoprotein (experimental). Outer membrane protein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY220.16SpII1720.7085Pos+2=A00Yn5-16c21/22oOuterMembrane9.9219.66
YFEY_ECOLIP76537
yfeY
b2432 JW2425 Uncharacterized protein yfeYLipoprotein (experimental). Outer membrane protein (experimental). Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002) PMID: 15174130 Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 12488465 PMID: 20932056 PMID: 25664544Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLyesyesY290.248SpII1720.3796Pos+2=S00Yn8-19c27/28oUnknown259.44
YPFG_ECOLIP76559
ypfG
b2466 JW2450 Uncharacterized protein ypfG Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY220.804SpI2115.2807-10Yn5-16c21/22oCytoplasmicMembrane9.8661.8
YFHM_ECOLIP76578
yfhM
b2520 JW2504 Uncharacterized lipoprotein yfhM Identified DsbA substrate PMID: 19953543PMID: 19953543Inner Membrane LipoproteinESoluble IM FractionCell membrane | Lipid-anchorInner membrane lipoproteinSECDSBALOLyesyesY250.18SpII1728.7232Pos+2=D00Yn6-13c18/19oUnknown4.69
YQIG_ECOLIP76655
yqiG
b3046 JW5507 Putative outer membrane usher protein yqiGPutative chaperone–usher fimbrial operon (class π); Usher. Disulfide bridge (798 817) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel proteinfimbriaeSECBAMnoyesN210.333CYT0-0.200913-00="0"iOuterMembrane10
YQII_ECOLIP76656
yqiI
b3048 JW5509 Uncharacterized protein yqiIPutative chaperone–usher fimbrial operon (class π); Unknown function.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY220.868SpI2114.4478-00Yn4-14c21/22oUnknown285.34
OMPL_ECOLIP76773
ompL

yshA

yshAb3875 JW3846 Porin ompLOuter MembranePMID: 11080145Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane β-barrel protein (Experimental)SECBAMnoyesY210.672SpI2013.4725-00Yn6-16c20/21oOuterMembrane106.09
MATC_ECOLIP77188
matC

yagY

yagYb0292 JW0286 Uncharacterized protein matCPutative chaperone–usher fimbrial operon yag(class α); Unknown function.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY210.828SpI2012.558-00Yn5-15c20/21oUnknown2.525.54
YFCU_ECOLIP77196
yfcU
b4661 JW2334/JW2335 b2337 b2338Putative outer membrane usher protein yfcUOuter Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinCytoplasmicfimbriaeSECpseudogene (Ochman & Davalos, 2006)noyesY300.624SpI295.84101-00Yn11-21c29/30oOuterMembrane1079.33
YAIT_ECOLIP77199
yaiT
b4580 JW0362/JW5051 b0371 b0374Putative uncharacterized protein yaiTAg43 homologue; predicted autotransporter. Contains autotransporter beta-domain (IPR005546). Potential Srp-dependent autotransporter. Homologous to hemoglobin-binding protease hbp. Hbp is the only known autotransporter that is secreted through the integral membrane in a Srp-dependent manner.PMID: 15590781 PMID: 12466262Outer Membrane b-barrel proteinHN/APeriplasmicSRPSECAutotransporter(T5S)pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoY280.844SpI2723.6574-00Yn8-19c27/28oUnknown5.8755.09
DSBG_ECOLIP77202
dsbG

ybdP

ybdPb0604 JW0597 Thiol:disulfide interchange protein DsbGPeriplasmic Disulfide bridge (126 129) PMID: 15184683 Disulfide bond-containing protein PMID: 25664544PMID: 9383195 PMID: 15184683 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY180.618SpI1712.1105-00Yn5-12c17/18oPeriplasmic1050.7
CUSC_ECOLIP77211
cusC

ibeB ylcB

ibeB ylcBb0572 JW0561 Cation efflux system protein cusCLipoprotein (experimental) Cell outer membrane Outer mebrane protein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 21249122 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY220.405SpII1711.8848Pos+2=S00Yn6-15c20/21oOuterMembrane1027.76
CUSB_ECOLIP77239
cusB

ylcD

ylcDb0574 JW0563 Cation efflux system protein cusBMFP family function as auxiliary proteins or 'adaptors', connecting a primary porter in the cytoplasmic membrane of a Gram-negative bacterium with an outer membrane factor (OMF; TC #1.B.17) protein that serves a porin or channel function in the outer membrane.PMID: 19695261Peripheral inner membrane protein facing the periplasmF2N/AMembrane anchoredSECyesyesN290.243SpI287.5302-10Yn4-16c28/29oUnknown2.556.44
SFMC_ECOLIP77249
sfmC
b0531 JW0520 Chaperone protein sfmC Potential fimbrial sfm operon (class γ1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Might be is co-translationally translocated through Sec translocon. The precursor of SfmC harbouring hydrophobic signal sequence require SRP and FtsY in addition to SecA for maximal translocation. PMID: 24717922 The precursor of SfmC harbouring hydrophobic signal sequence require SRP and FtsY in addition to SecA for maximal translocation. PMID: 24717922 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024PMID: 18498364 PMID: 20345943 PMID: 15838024 PMID: 24717922 PMID: 15838024PeriplasmicGN/APeriplasmPeriplasmicfimbriaeSRP (exp)SECSURAyesyesY240.844SpI2314.9715-10Yn7-18c23/24oPeriplasmic1028.49
YDJG_ECOLIP77256
ydjG
b1771 JW1760 Uncharacterized oxidoreductase ydjG (EC 1.-.-.-)PeriplasmicGN/APeriplasmicSECnoyesN310.18CYT0-0.200913-00="0"iCytoplasmic9.9710.37
YAGV_ECOLIP77263
yagV
b0289 JW5030 Uncharacterized protein yagVPutative chaperone–usher fimbrial operon yag(class α); Unknown function. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Disulfide bond-containing protein PMID: 25664544PMID: 18498364 PMID: 20345943 PMID: 25664544PeriplasmicGN/APeriplasmicfimbriaeSECSURAnoyesY280.534SpI278.52618-10Yn12-22c27/28oUnknown2.517.86
YPHF_ECOLIP77269
yphF
b2548 JW2532 ABC transporter periplasmic-binding protein yphFPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY270.817SpI2620.8859-00Yn11-22c26/27oPeriplasmic9.7663.54
YFCV_ECOLIP77288
yfcV
b2339 JW2336 Uncharacterized fimbrial-like protein yfcVPutative chaperone–usher fimbrial operon yfc (class π); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECCUyesyesY260.533SpI2514.9857-10Yn7-18c25/26oUnknown2.597.97
YDER_ECOLIP77294
ydeR
b1503 JW1497 Uncharacterized fimbrial-like protein ydeRPotential fimbrial yde operon (class γ1); Fimbrial Subunit. Disulfide bridge (39 77) PMID: 19820722 PMID: 20345943 PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECCUnoyesY240.701SpI2320.0135-00Yn8-18c23/24oUnknown2.567.33
YDEN_ECOLIP77318
ydeN
b1498 JW5243 Uncharacterized sulfatase ydeN (EC 3.1.6.-)PeriplasmicGN/APeriplasmicSECnoyesY300.809SpI2924.3093-00Yn9-20c29/30oUnknown6.4956.55
BORD_ECOLIP77330
borD

ybcU

ybcUb0557 JW0546 Lipoprotein bor homolog from lambdoid prophage DLP12Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130 Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionCell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLProphage Integrase (EcoGene)nonoY210.303SpII1621.3732Pos+2=A00Yn5-14c18/19oUnknown2.532.74
YAFT_ECOLIP77339
yafT
b0217 JW0206 Uncharacterized lipoprotein yafTOuter membrane Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY210.197SpII1823.0916Pos+2=A00Yn6-16c21/22oUnknown2.561.21
MPPA_ECOLIP77348
mppA

ynaH

ynaHb1329 JW1322 Periplasmic murein peptide-binding proteinPeriplasmicPMID: 9495761PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY230.7SpI228.93006-00Yn4-14c22/23oPeriplasmic1032.09
YBCL_ECOLIP77368
ybcL
b0545 JW0533 UPF0098 protein ybcLPeriplasm Disulfide bridge (46 129) Disulfide bond-containing protein PMID: 25664544PMID: 11439028 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECProphage Integrase (EcoGene)yesnoY200.717SpI1919.8157-00Yn4-15c19/20oPeriplasmic1048.6
SFMD_ECOLIP77468
sfmD
b0532 JW0521 Outer membrane usher protein sfmDPotential fimbrial sfm operon (class γ1); Usher. Disulfide bridge (840 862) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel proteinfimbriaeSECBAMyesyesN360.404TMH03.9822-11="0"i12-32oOuterMembrane10
YAIW_ECOLIP77562
yaiW
b0378 JW0369 Uncharacterized protein yaiWOuter membrane protein (experimental). Disulfide bond-containing protein PMID: 25664544PMID: 20932056 PMID: 25664544Outer Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLnoyesY260.354SpII2028.9818Pos+2=S00Yn7-18c23/24oUnknown2.510.13
YDEQ_ECOLIP77588
ydeQ
b1502 JW1496 Uncharacterized fimbrial-like protein ydeQCell surface appendagePotential fimbrial yde operon (class γ1); Potential tip-adhesin. PMID: 20345943PMID: 19820722 PMID: 20345943 PMID: 18498364 PMID: 20345943 PMID: 20345943PeriplasmicGN/AFimbriumPeriplasmicfimbriaeSECSURACUnoyesN250.739SpI2410.2575-00Yn9-19c24/25oUnknown261.96
YFCS_ECOLIP77599
yfcS
b2336 JW2333 Uncharacterized fimbrial chaperone yfcSPutative chaperone–usher fimbrial operon yfc (class π); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmPeriplasmicfimbriaeSECSURAyesyesY290.747SpI2811.2467-00Yn10-21c28/29oPeriplasmic1077.61
YQIH_ECOLIP77616
yqiH
b3047 JW5508 Uncharacterized fimbrial chaperone yqiHPutative chaperone–usher fimbrial operon (class π); Chaperone.PMID: 20345943Outer Membrane b-barrel proteinHN/APeriplasmOuter Membrane β-barrel proteinfimbriaeSECBAMnoyesY260.426SpI2512.7072-10Yn9-20c25/26oPeriplasmic1021.97
YFEW_ECOLIP77619
yfeW
b2430 JW5395 Uncharacterized protein yehAPeriplasmicGN/APeriplasmicSECnoyesY200.512SpI1910.3062-00Yn6-14c19/20oPeriplasmic9.76
YAGW_ECOLIP77694
yagW
b0290 JW0284 Uncharacterized protein yagWPutative chaperone–usher fimbrial operon yag(class α); Unknown function. Putative Outer membrane protein (BOMB prediction + SignalP 98% prediction).PMID: 20345943Outer Membrane b-barrel proteinHN/ACytoplasmicfimbriaeSECBAMnoyesN320.295SpI237.3263-00Yn5-16c23/24oUnknown4.652.33
YBAY_ECOLIP77717
ybaY
b0453 JW0443 Uncharacterized lipoprotein ybaYOuter membrane Lipoprotein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY180.379SpII1821.022Pos+2=A00Yn3-14c19/20oPeriplasmic9.84
OMPN_ECOLIP77747
ompN

ynaG

ynaGb1377 JW1371 Outer membrane protein N (Porin ompN)Outer membrane protein (experimental). Outer Membrane ss-barrel proteinPMID: 20932056 PMID: 9642192Outer Membrane b-barrel proteinHN/ACell outer membrane | Multi-pass membrane proteinOuter Membrane β-barrel protein (Experimental)SECBAMyesyesY220.895SpI2124.6239-00Yn5-16c21/22oOuterMembrane1010.37
BAMB_ECOLIP77774
yfgL

yfgL

yfgLb2512 JW2496 Lipoprotein yfgLLipoprotein (experimental). Outer membrane protein (experimental). Outer membrane protein (experimental).Part of bam complex. Interacts directry with BamA. Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 15174130PMID: 15174130 PMID: 15851030 PMID: 21823654 PMID: 21236263 PMID: 21370981 PMID: 15911532 PMID: 20932056Outer Membrane LipoproteinISoluble IM FractionCell outer membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY270.152SpII1914.7873Pos+2=S00Yn6-17c25/26oOuterMembrane10
YDES_ECOLIP77789
ydeS
b1504 JW1498 Uncharacterized fimbrial-like protein ydeSPotential fimbrial yde operon (class γ1); Fimbrial Subunit. Disulfide bridge (38 78) PMID: 19820722 PMID: 20345943 Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbriumMembrane anchoredfimbriaeSECCUnoyesY230.426SpI2211.5353-10Yn6-17c22/23oExtracellular1079.19
YAGX_ECOLIP77802
yagX
b0291 JW0285 Uncharacterized protein yagXPutative chaperone–usher fimbrial operon yag(class α); Usher. Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364 PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECSURAnoyesY300.522SpI291.61886-00Yn12-23c29/30oUnknown4.69
YDGA_ECOLIP77804
ydgA
b1614 JW1606 Protein ydgACell inner membrane, Peripheral membrane protein, Periplasmic side Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338PMID: 16079137 PMID: 21541338Peripheral inner membrane protein facing the periplasmF2Soluble IM FractionCell inner membrane | Peripheral membrane protein | Periplasmic sideCytoplasmicSECyesyesN250.174SpI243.81151-10Yn4-14c19/20oCytoplasmicMembrane1025.92
YNJE_ECOLIP78067
ynjE
b1757 JW5287 Thiosulfate sulfurtransferase YnjE (EC 2.8.1.1) Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Potential substrate of periplasmic chaperone YfgM). PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 18498364 PMID: 25403562 PMID: 25403562PeriplasmicGN/APeriplasmPeriplasmicSECSURA,YfgMyesyesY240.698SpI2321.4185-00Yn8-18c23/24oPeriplasmic1040.69
YGER_ECOLIQ46798
ygeR
b2865 JW2833 Uncharacterized lipoprotein ygeROuter membrane Lipoprotein (experimental). Outer membrane protein (experimental). Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell membrane | Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN330.262SpII2522.1379Pos+2=S00Yn11-23c28/29oOuterMembrane9.9358.4
YQHG_ECOLIQ46858
yqhG

yqhF

yqhFb3013 JW5500 Uncharacterized protein yqhGPotential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAnoyesY190.889SpI1817.8226-00Yn3-14c18/19oUnknown4.984.28
YGIS_ECOLIQ46863
ygiS
b3020 JW2988 Putative binding protein ygiSPeriplasmicGN/APeriplasmPeriplasmicSECyesyesY210.755SpI2013.5931-00Yn6-16c20/21oPeriplasmic9.7627.09
YAFL_ECOLIQ47151
yafL
b0227 JW0217 Uncharacterized lipoprotein yafLPeriplasmicGN/ACell membrane | Lipid-anchorPeriplasmicSECyesyesY260.582SpI2711.7588-10Yn8-19c37/38oUnknown4.934.64
TAUA_ECOLIQ47537
tauA

ssiA yaiR

ssiA yaiRb0365 JW0357 Taurine-binding periplasmic protein (Sulfate starvation-induced protein 1) (SSI1)PeriplasmicPMID: 8774726PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY230.816SpI2216.0488-00Yn8-18c22/23oPeriplasmic9.84
SAPA_ECOLIQ47622
sapA
b1294 JW1287 Peptide transport periplasmic protein sapAPeriplasmic Potential substrate of periplasmic peptidyl prolyl cis–trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 9593292PMID: 18498364 PMID: 9593292PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSURAyesyesY220.865SpI2114.8036-00Yn4-15c21/22oPeriplasmic1030.87
UIDC_ECOLIQ47706
uidC

gusC

gusCb1615 JW1607 Membrane-associated protein uidCOuter MembranePMID: 15774881Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane β-barrel protein (Experimental)SECBAMnoyesY240.665SpI2313.3065-10Yn4-15c23/24oOuterMembrane9.523.64