entryaccgenealt_geneolnprotein_namecm_locacm_notescm_refssuboci_fullsublocisubloci_iimnterm_ctermbernselsubloci_uniprotsubloci_echoLorganelletarget_chaperoning11st_sstarget_chaperoning22nd_sspseudocommon_corebasic_proteomesignalp_sp_existsignalp_possignalp_cmaxlipop_predlipop_cleavagelipop_scorelipop_ruletmhmmphobius_tmsphobius_sp_existphobius_predictionpsortb_locapsortb_scoresolubility
YJBT_ECOLIA5A628
yjbT
b4620 periplasmic protein (SEC through IM), YjbTBelongs to the yjbT family.PeriplasmicGN/A-SECnoyesY300.744SpI2915.6556-10Yn15-25c29/30oPeriplasmic9
RZOQ_ECOLIC1P601
rzoQ
b4689 JW1545.1 IM lipoprotein (SEC through IM), inserted in OM by LOL), Putative RzoQInner Membrane LipoproteinEN/ACell membrane -SECLOLnoyesN290.129SpII2211.4311Pos+2=V00Yn9-20c25/26oUnknown2
YPDI_ECOLIO32528
ypdI
b2376 JW2373 OM lipoprotein (SEC through IM, inserted in OM by LOL), YpdIOuter Membrane LipoproteinIN/ACell membrane Outer membrane LipoproteinSECLOLnoyesY240.415SpII1812.5879Pos+2=N10Yn5-16c23/24oUnknown222
YFJS_ECOLIO52982
yfjS
b2636 JW5921 IM lipoprotein (SEC through IM, inserted in OM by LOL), YfjSInner Membrane LipoproteinEN/ACell inner membrane Inner membrane lipoproteinSECLOLProphage Integrase (EcoGene)nonoY210.479SpII2018.7233Pos+2=D00Yn6-17c21/22oUnknown2
PPB_ECOLIP00634
phoA
b0383 JW0374 periplasmic protein (SEC through IM), Alkaline phosphatase PhoAPeriplasmicSubstrate of periplasmic disulfide oxidoreductases DsbA. Alkaline phosphatase (EC 3.1.3.1; APase) of E.coli is a periplasmic enzyme. PMID: 3533724 Alkaline phosphatase (EC 3.1.3.1; APase) of E.coli is a periplasmic enzyme. PMID: 3533724 Identified DsbA substrate PMID: 19953543 PMID: 7022451 An amber mutation in the secA gene of Escherichia coli causes a pleiotropic decrease in the synthesis of secreted proteins. PMID: 3009404 Disulfide bridges (190 200;308 358) Disulfide bridges (190 200;308 358) Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 3533724 PMID: 19953543 PMID: 7022451 PMID: 3009404 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAnoyesY220.408SpI213.05238-00Yn5-16c21/22oPeriplasmic1078
ASPG2_ECOLIP00805
ansB
b2957 JW2924 periplasmic protein (SEC through IM), L-asparaginase 2 AnsBPeriplasmicPMID: 387570 PMID: 2407723 PMID: 25403562 PMID: 8434007 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY230.82SpI2219.7315-10Yn7-17c22/23oPeriplasmic1049
YGDB_ECOLIP08370
ygdB
b2824 JW5450 periplasmic protein (SEC through IM), YgdBPeriplasmicGN/APeriplasmicSECyesyesN270.147SpI267.55205-10Yn10-23c35/36oUnknown27
YCCT_ECOLIP0A8X4
yccT
b0964 JW0947 periplasmic protein (SEC through IM), UPF0319 YccTPeriplasmicGN/APeriplasmicSECyesyesY210.531SpI206.4525-00Yn3-14c20/21oUnknown260
YOBA_ECOLIP0AA57
yobA
b1841 JW1830 periplasmic protein (SEC through IM), YobAPeriplasmicGN/APeriplasm PeriplasmicSECyesyesY270.511SpI2613.4937-00Yn11-21c26/27oPeriplasmic9
AMPC_ECOLIP00811
ampC

ampA

ampAb4150 JW4111 periplasmic protein (SEC through IM), Beta-lactamase AmpCPeriplasmicPMID: 6795623PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY200.854SpI1917.1519-00Yn4-15c19/20oPeriplasmic1026
ARAF_ECOLIP02924
araF
b1901 JW1889 periplasmic protein (SEC through IM), L-arabinose-binding periplasmic AraFPeriplasmicPMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY240.816SpI2320.0244-00Yn7-18c23/24oPeriplasmic1086
RBSB_ECOLIP02925
rbsB

prlB rbsP

prlB rbsPb3751 JW3730 periplasmic protein (SEC through IM), Ribose import binding RbsB Periplasmic Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 15911532 PMID: 19953543 PMID: 9298646PeriplasmicGSoluble IM FractionPeriplasm Periplasmic (Experimental)SECSKPnoyesY260.839SpI2522.7093-00Yn6-17c25/26oPeriplasmic1093
TOLC_ECOLIP02930
tolC

colE1-i mtcB mukA refI

colE1-i mtcB mukA refIb3035 JW5503 OM b-barrel protein (SEC through IM, inserted in OM by BAM), TolCOuter Membrane b-barrel proteinPart of MdtABC-TolC multidrug efflux transport system = [(TolC)3][MdtC][MdtB][MdtA]. Also part of MacAB-TolC macrolide efflux transport system = [(TolC)3][MacB]2[MacA]. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000).The crystal structure of MacA has been determined at 3.0A resolution. The inner membrane transporter MacB requires the outer membrane factor TolC and the periplasmic adaptor protein MacA to form a functional tripartite complex. Electron microscopic indicates that the MacA hexamer interacts with TolCIn a tip-to-tip manner. Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 12107133 PMID: 19254725 PMID: 21325274 PMID: 16372265 PMID: 16352602 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 10879525 PMID: 15228545 PMID: 16079137 PMID: 21778229 PMID: 20932056 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane Outer Membrane ??-barrel protein (Experimental)SECBSECSKPBAMyesyesY230.712SpI2210.2716-00Yn4-14c22/23oOuterMembrane1015
YACC_ECOLIP0AA95
yacC
b0122 JW0118 periplasmic protein (SEC through IM), YacCPeriplasmicGN/APeriplasmicSECyesyesY230.239SpI2410.6167-00Yn7-17c22/23oUnknown221
ZRAP_ECOLIP0AAA9
zraP

yjaI zra

yjaI zrab4002 JW5546 periplasmic protein (SEC through IM), Zinc resistance-associated protein ZraPPeriplasmicPMID: 9694902 PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY270.74SpI2628.6968-10Yn7-18c26/27oPeriplasmic10
OMPF_ECOLIP02931
ompF

cmlB coa cry tolF

cmlB coa cry tolFb0929 JW0912 OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpFOuter Membrane b-barrel proteinSubstrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Potential pubstrate of periplasmic chaperones Skp. Outer membrane proteins OmpF, OmpC, and OmpX as central to the YebF export mechanism. Trigger factor-sensitive aggregation. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 9298646PMID: 8626309 PMID: 17908933 PMID: 19343722 PMID: 22658749 PMID: 19737520 PMID: 12488465 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 1380671 PMID: 11266632 PMID: 16079137 PMID: 20932056 PMID: 21541338 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane Outer Membrane ??-barrel protein (Experimental)TFSECSKP,SURABAMyesyesY230.883SpI2219.9098-00Yn6-17c22/23oOuterMembrane1018
PHOE_ECOLIP02932
phoE

ompE

ompEb0241 JW0231 OM b-barrel protein (SEC through IM, inserted in OM by BAM), PhoEOuter Membrane b-barrel proteinPMID: 1380671 PMID: 11266632 PMID: 20932056 PMID: 216015Outer Membrane b-barrel proteinHN/ACell outer membrane; Multi-pass membrane proteinOuter Membrane ??-barrel protein (Experimental)SECBAMyesyesY220.841SpI2121.3546-00Yn5-16c21/22oOuterMembrane102
LAMB_ECOLIP02943
lamB

malB

malBb4036 JW3996 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Maltoporin LamBOuter Membrane b-barrel proteinPotential pubstrate of periplasmic chaperones Skp. Substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy 2000). Experimentally verified trimeric beta-barrel. N-terminal region is in periplasm. Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 346375 Disulfide bridges between 47 and 63 PMID: 1988451 Disulfide bond-containing protein PMID: 25664544PMID: 16372265 PMID: 8626309 PMCID: PMC1993877 PMID: 19343722 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 7824948 PMID: 11266632 PMID: 16079137 PMID: 20932056 PMID: 19953543 PMID: 346375 PMID: 1988451 PMID: 25664544Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane Outer Membrane ??-barrel protein (Experimental)SECSKP,SURA,DEGPBAMyesyesY260.795SpI2520.7922-00Yn8-18c25/26oOuterMembrane1054
YKGJ_ECOLIP0AAL9
ykgJ
b0288 JW0282 periplasmic protein (SEC through IM), YkgJPeriplasmicPeriplasmicGN/APeriplasmicSECnoyesN270.286SpI244.7292-00NiUnknown233
YBAV_ECOLIP0AAR8
ybaV
b0442 JW0432 periplasmic protein (SEC through IM), YbaVPeriplasmicGN/APeriplasmicSECyesyesY260.681SpI2523.157-00Yn7-17c25/26oCytoplasmicMembrane9
YBGS_ECOLIP0AAV6
ybgS
b0753 JW0736 periplasmic protein (SEC through IM), YbgSPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY250.845SpI2432.7676-00Yn6-17c24/25oPeriplasmic9
MALM_ECOLIP03841
malM

molA

molAb4037 JW3997 periplasmic protein (SEC through IM), Maltose operon periplasmic protein MalMPeriplasmicPMID: 2434655PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY270.606SpI2624.5925-00Yn7-18c26/27oPeriplasmic10
FIMA1_ECOLIP04128
fimA

pilA

pilAb4314 JW4277 Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), Type-1 protein, A chain FimAPeripheral outer membrane protein facing the extra-cellular spaceFim operon (class ??1); Fimbrial Subunit. Experimentally verified signal peptide PMID: 2858471 Disulfide bridge (44 84) Disulfide bond-containing protein PMID: 25664544PMID: 20345943 PMID: 6147250 PMID: 2858471 PMID: 25664544Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbriumCell surface appendage (Experimental)fimbriaeSECCUyesyesY240.78SpI2325.7568-10Yn5-16c23/24oExtracellular10
LIVK_ECOLIP04816
livK
b3458 JW3423 periplasmic protein (SEC through IM), Leucine-specific-binding LivKPeriplasmic Identified DsbA substrate PMID: 19953543 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bridge (76 101) Disulfide bridge (42 47) PMID: 8061609 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 9298646 PMID: 22030350 PMID: 8061609 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY240.817SpI2317.7516-00Yn7-18c23/24oPeriplasmic1078
NLPA_ECOLIP04846
nlpA
b3661 JW3635 IM lipoprotein (SEC through IM, inserted in OM by LOL), NlpAInner Membrane Lipoprotein Proven signal peptidase II substrate.PMID: 15174130Inner Membrane LipoproteinESoluble IM FractionCell inner membrane; Lipid-anchorInner membrane lipoproteinSECLOLyesyesY230.355SpII2321.7987Pos+2=D00Yn10-21c26/27oCytoplasmicMembrane1077
PTRA_ECOLIP05458
ptrA

ptr

ptrb2821 JW2789 periplasmic protein (SEC through IM), Protease 3 PtrAPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 15502359PMID: 18498364 PMID: 15502359PeriplasmicGN/APeriplasmPeriplasmic(experimental)SECSURAyesyesY240.815SpI2313.0719-00Yn9-18c23/24oPeriplasmic1066
YBIJ_ECOLIP0AAX3
ybiJ
b0802 JW0787 periplasmic protein (SEC through IM), YbiJPeriplasmicGN/APeriplasm PeriplasmicSECyesyesY230.811SpI2221.8351-10Yn7-18c22/23oUnknown2
MCBA_ECOLIP0AAX6
mcbA

ybiM

ybiMb0806 JW5106 periplasmic protein (SEC through IM), McbAPeriplasmicGN/APeriplasm PeriplasmicSECyesyesY230.869SpI2218.838-10Yn4-14c22/23oUnknown2
FEPA_ECOLIP05825
fepA

fep feuB

fep feuBb0584 JW5086 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Ferrienterobactin receptor FepAOuter Membrane b-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 10529396 Disulfide bond-containing protein PMID: 25664544PMID: 12624733 PMID: 11266632 PMID: 9886293 PMID: 20932056 PMID: 10806384 PMID: 19953543 PMID: 10529396 PMID: 25664544Outer Membrane b-barrel proteinHN/ACell outer membrane; Multi-pass membrane proteinOuter Membrane ??-barrel protein (Experimental)SECSKPBAMyesyesY230.836SpI2211.5401-00Yn7-17c22/23oOuterMembrane1011
BTUB_ECOLIP06129
btuB

bfe cer dcrC

bfe cer dcrCb3966 JW3938 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Vitamin B12 transporter BtuB Outer Membrane b-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 12652322 PMID: 2982793 PMID: 2687240 PMID: 12595710 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel protein (Experimental)SECSKPBAMnoyesY210.828SpI2021.8455-00Yn5-16c20/21oOuterMembrane10
CDH_ECOLIP06282
cdh
b3918 JW3889 periplasmic protein (SEC through IM), CDP-diacylglycerol pyrophosphatase CdhPeriplasmicGSoluble IM FractionCell inner membrane; Single-pass membrane proteinMembrane anchoredSECyesyesN190.264SpI197.43557-10Yn4-14c19/20oCytoplasmicMembrane1055
YBJH_ECOLIP0AAY4
ybjH
b0843 JW0827 periplasmic protein (SEC through IM), YbjHPeriplasmicGN/APeriplasmicSECyesyesY230.874SpI2225.9172-10Yn6-17c22/23oUnknown210
YCEK_ECOLIP0AB31
yceK
b1050 JW5151 OM lipoprotein (SEC through IM, inserted in OM by LOL), YceKOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLnoyesN310.129SpII155.35698Pos+2=G00Yn3-13c18/19oUnknown2
YMGD_ECOLIP0AB46
ymgD
b1171 JW5177 periplasmic protein (SEC through IM), YmgDPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECnoyesY200.656SpI1914.7848-00Yn4-14c19/20oUnknown286
HOKC_ECOLIP0ACG4
hokC

gef

gefb4412 JW5002 b0018.1periplasmic protein (SEC through IM), Toxic HokC PeriplasmicPotentially toxic protein.PMID: 19121005 PMID: 21890895PeriplasmicGN/ACell inner membrane PeriplasmicSECnoyesN220.361SpI215.3199-10Yn8-16c21/22oPeriplasmic932
FHUA_ECOLIP06971
fhuA

tonA

tonAb0150 JW0146 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Ferrichrome transporter/phage receptor FhuAOuter Membrane b-barrel proteinSecB substrate; Substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 3079747 Disulfide bridge (351 362;725 731) Disulfide bond-containing protein PMID: 25664544PMID: 16352602 PMID: 19343722 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 9856937 PMID: 19953543 PMID: 3079747 PMID: 25664544Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel protein (Experimental)SECBSECSURA,SKPBAMyesyesY340.805SpI3320.4987-00Yn16-24c33/34oOuterMembrane107
OMPC_ECOLIP06996
ompC

meoA par

meoA parb2215 JW2203 OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpCOuter Membrane b-barrel proteinOuter membrane protein related to resistance to ampicillin and tetracycline; Potential pubstrate of periplasmic chaperones Skp. Outer membrane proteins OmpF, OmpC, and OmpX as central to the YebF export mechanism. Trigger factor-sensitive aggregation. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 16372265 PMID: 17908933 PMID: 22658749 PMID: 19737520 PMID: 12488465 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 21541338 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane; Multi-pass membrane proteinOuter Membrane ??-barrel protein (Experimental)TFSECSKPBAMyesyesY220.884SpI2121.1188-00Yn5-16c21/22oOuterMembrane106
YFIB_ECOLIP07021
yfiB
b2605 JW2586 OM lipoprotein (SEC through IM), inserted in OM by LOL), Putative YfiBOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesN250.134SpII1818.8761Pos+2=Q00Yn5-16c20/21oOuterMembrane974
HOKD_ECOLIP0ACG6
hokD

relF

relFb1562 JW1554 periplasmic protein (SEC through IM), Toxic HokD PeriplasmicGN/ACell inner membrane PeriplasmicSECProphage Integrase (EcoGene)nonoN230.157SpI222.62207-10Yn8-19c26/27oPeriplasmic9
YDBJ_ECOLIP0ACW2
ydbJ
b4529 JW5215 OM lipoprotein (SEC through IM, inserted in OM by LOL), YdbJOuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLnoyesY250.374SpII1617.2226Pos+2=S00Yn3-14c19/20oUnknown224
YDCA_ECOLIP0ACW4
ydcA
b1419 JW1416 periplasmic protein (SEC through IM), YdcAPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECnoyesY210.761SpI2012.9463-00Yn4-15c20/21oUnknown2
OSMB_ECOLIP0ADA7
osmB
b1283 JW1275 OM lipoprotein (SEC through IM), inserted in OM by LOL), Osmotically-inducible B OsmBOuter Membrane LipoproteinProven signal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesY240.336SpII2322.8573Pos+2=S00Yn9-17c22/23oCytoplasmicMembrane9
USHA_ECOLIP07024
ushA
b0480 JW0469 periplasmic protein (SEC through IM), UshAPeriplasmicPMID: 9298646 PMID: 25664544PeriplasmicGSoluble IM FractionPeriplasm Periplasmic (Experimental)SECnoyesY260.748SpI2511.3752-00Yn7-18c25/26oPeriplasmic1077
PPA_ECOLIP07102
appA
b0980 JW0963 periplasmic protein (SEC through IM), AppA Periplasmic Identified DsbC substrate PMID: 19953543 PMID: 8387749 Disulfide bridge (99 130;155 430;200 210;404 413) Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 8387749 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBCyesyesY230.793SpI2213.6965-00Yn3-13c22/23oPeriplasmic1066
FIMF_ECOLIP08189
fimF
b4318 JW4281 Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), FimFPeripheral outer membrane protein facing the extra-cellular spaceFim operon (class ??1); Fimbrial Subunit. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. PMID: 15372038 Disulfide bridge (38 78) Disulfide bond-containing protein PMID: 25664544PMID: 19820722 PMID: 2890081 PMID: 20345943 PMID: 15372038 PMID: 25664544Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbriumCell surface appendage (Experimental)fimbriaeSECCUnoyesY230.871SpI2217.2366-00Yn6-17c22/23oExtracellular9
FIMG_ECOLIP08190
fimG
b4319 JW4282 Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), FimGPeripheral outer membrane protein facing the extra-cellular spaceFim operon (class ??1); Fimbrial Subunit. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. PMID: 15372038 Disulfide bridge (39 77) Disulfide bond-containing protein PMID: 25664544PMID: 19820722 PMID: 2890081 PMID: 20345943 PMID: 15372038 PMID: 25664544Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbriumCell surface appendage (Experimental)fimbriaeSECCUnoyesY240.773SpI2318.1281-10Yn7-18c23/24oExtracellular973
ECNA_ECOLIP0ADB4
ecnA
b4410 JW5737 OM lipoprotein (SEC through IM), inserted in OM by LOL), Entericidin A EcnAOuter Membrane LipoproteinSmall membrane protein detected experimentally. Proven pignal peptidase II substrate. PMID: 15174130PMID: 19121005 PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane; Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY230.254SpII1814.5257Pos+2=N00Yn5-16c21/22oCytoplasmicMembrane10
YIDQ_ECOLIP0ADM4
yidQ
b3688 JW5633 IM lipoprotein (SEC through IM, inserted in OM by LOL), YidQInner Membrane LipoproteinPMID: 11274153Inner Membrane LipoproteinEN/AOuter membrane Lipoprotein(experimental)SECLOLyesyesY270.185SpII2016.396Pos+2=S00Yn5-18c26/27oUnknown2114
YIDX_ECOLIP0ADM6
yidX
b3696 JW5858 OM lipoprotein (SEC through IM, inserted in OM by LOL), YidXOuter Membrane LipoproteinIN/AMembrane Outer membrane LipoproteinSECLOLpseudogene (Ochman & Davalos, 2006)noyesY290.411SpII2320.6632Pos+2=I10Yn11-21c26/27oUnknown254
FIMH_ECOLIP08191
fimH
b4320 JW4283 Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), Type 1 fimbrin D-mannose specific adhesin FimHPeripheral outer membrane protein facing the extra-cellular spaceFim operon (class ??1); Potential tip-adhesin. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. PMID: 1971261 PMID: 2900235 PMID: 2890081PMID: 19820722 PMID: 2890081 PMID: 20345943 PMID: 1971261 PMID: 2900235 PMID: 24140205Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbrium Cell surface appendage (Experimental)fimbriaeSECCUnoyesY200.539SpI2114.3197-00Yn4-14c19/20oUnknown419
CPDB_ECOLIP08331
cpdB
b4213 JW4171 periplasmic protein (SEC through IM), 2',3'-cyclic-nucleotide 2'-phosphodiesterase/3'-nucleotidase CpdBPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. References: Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 9298646 Disulfide bond-containing protein PMID: 25664544PMID: 18498364 PMID: 3005231 PMID: 15911532 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECSURAnoyesY200.787SpI1914.5002-00Yn4-14c19/20oPeriplasmic1082
DACC_ECOLIP08506
dacC
b0839 JW0823 periplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine carboxypeptidase DacCPeripheral inner membrane protein facing the periplasmPutative amphiphilic alpha-helical anchor at the C-terminusPMID: 8162192. PMID: 9858669 DacC(PBP-6) anchors to the periplasmic face of the inner membrane via C-terminal amphiphilic alpha-helix. The Alpha-helical conformation in the C-terminal anchoring domain is observed in aqueous solution or in the presence of phospholipid vesicles. PMID: 9371419PMID: 8162192 PMID: 9858669 PMID: 9371419Peripheral inner membrane protein facing the periplasmF2Soluble IM FractionCell inner membrane Membrane anchored (Experimental)SECyesyesY280.887SpI2718.4084-00Yn11-22c27/28oCytoplasmicMembrane921
YGGE_ECOLIP0ADS6
yggE
b2922 JW2889 periplasmic protein (SEC through IM), YggEPeriplasmicGN/APeriplasmicSECyesyesY220.409SpI2116.0009-00Yn5-16c21/22oPeriplasmic9111
YGIW_ECOLIP0ADU5
ygiW
b3024 JW2992 periplasmic protein (SEC through IM), YgiWPeriplasmicSecB substrate. PMID: 9298646PMID: 16352602 PMID: 9298646PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECBSECyesyesY210.877SpI2026.1756-00Yn4-15c20/21oUnknown228
LPTA_ECOLIP0ADV1
lptA

yhbN

yhbNb3200 JW3167 periplasmic protein (SEC through IM), polysaccharide export system LptA PeriplasmicPMID: 17056748 PMID: 18480051 PMID: 9298646PeriplasmicGN/APeriplasm Periplasmic(experimental)SECyesyesY280.838SpI2724.4302-00Yn12-23c27/28oUnknown223
OMPT_ECOLIP09169
ompT
b0565 JW0554 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Protease 7 OmpTOuter Membrane b-barrel proteinSecB substrate. Trigger factor-sensitive aggregation. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 9298646PMID: 16352602 PMID: 19737520 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 11566868 PMID: 21541338 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane; Multi-pass membrane proteinOuter Membrane ??-barrel protein (Experimental)SECB,TFSECBAMProphage Integrase (EcoGene)nonoY210.295SpI207.49489-00Yn5-16c20/21oOuterMembrane103
GLPQ_ECOLIP09394
glpQ
b2239 JW2233 periplasmic protein (SEC through IM), Glycerophosphodiester phosphodiesterase, periplasmic GlpQPeriplasmicPMID: 2829735 PMID: 1851953PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY260.712SpI2517.875-00Yn8-18c25/26oPeriplasmic1039
ARGT_ECOLIP09551
argT
b2310 JW2307 periplasmic protein (SEC through IM), Lysine/arginine/ornithine-binding periplasmic ArgTPeriplasmicThis periplasmic binding protein is involved in an arginine transport system. ArgT and histidine-binding protein J (hisJ) interact with a common membrane-bound receptor, hisP. Phosphorylated by ArgKPMID: 2136858. Identified DsbA substrate PMID: 19953543 PMID: 9298647 PMID: 9298646 Disulfide bridge (60 67) Disulfide bond-containing protein PMID: 25664544PMID: 2136858 PMID: 19953543 PMID: 9298647 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY230.595SpI2219.5206-00Yn4-14c22/23oPeriplasmic10
FLGH_ECOLIP0A6S0
flgH

fla FVIII flaY

fla FVIII flaYb1079 JW5153 Flagellar OM lipoprotein (SEC through IM), inserted in OM by LOL), L-ring FlgHOuter Membrane Lipoprotein Proven pignal peptidase II substrate. L ring protein. PMID: 15174130PMID: 15174130 PMID: 12631703 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein (Experimental)flagellumSECLOLyesyesY240.235SpII2117.0713Pos+2=A00Yn14-25c33/34oOuterMembrane1024
YHHA_ECOLIP0ADX7
yhhA
b3448 JW3413 periplasmic protein (SEC through IM), YhhAPeriplasmicGN/APeriplasmicSECyesyesY180.377SpI1714.5283-00Yn4-11c17/18oUnknown2107
CREA_ECOLIP0AE91
creA

yjjD

yjjDb4397 JW4360 periplasmic protein (SEC through IM), CreAPeriplasmic Identified DsbA substrate PMID: 19953543 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 25664544PeriplasmicGN/APeriplasmicSECDSBAyesyesY220.8SpI2114.9398-00Yn6-16c21/22oUnknown2
YJBE_ECOLIP0AF45
yjbE
b4026 JW3986 periplasmic protein (SEC through IM), YjbEPeriplasmicGN/APeriplasmicSECnoyesY220.853SpI2125.8362-00Yn4-15c21/22oExtracellular9
FLGI_ECOLIP0A6S3
flgI

fla FIX flaM

fla FIX flaMb1080 JW1067 Flagellar periplasmic protein (SEC through IM), P-ring FlgIPeriplasmicP ring protein. Substrate of periplasmic disulfide oxidoreductases DsbA. Might be is co-translationally translocated through Sec translocon. Identified DsbA substrate PMID: 19953543 PMID: 12730325 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024PMID: 14726535 PMID: 12631703 PMID: 15838024 PMID: 19953543 PMID: 12730325PeriplasmicGN/APeriplasm Bacterial flagellum basal bodyPeriplasmic (Experimental)flagellumSRP (exp)SECDSBAFlanoyesY200.783SpI1915.6262-00Yn4-14c19/20oPeriplasmic1063
TOLB_ECOLIP0A855
tolB
b0740 JW5100 periplasmic & peripheral OM protein (SEC through IM), Tol-Pal system TolB Periplasmic, Peripheral outer membrane protein facing the periplasmSecB substrate. Might be is co-translationally translocated through Sec translocon. PMID: 17233825 PMID: 7929011 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024PMID: 16352602 PMID: 15838024 PMID: 7929011 PMID: 17233825Periplasmic, Peripheral outer membrane protein facing the periplasmG, F3Soluble IM FractionPeriplasm Periplasmic (Experimental)SECB, SRPSECnoyesN220.555SpI217.66433-00Yn7-16c21/22oPeriplasmic1031
YCEI_ECOLIP0A8X2
yceI
b1056 JW1043 periplasmic protein (SEC through IM), YceIPeriplasmicPMID: 9298646 PMID: 22030350PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY230.827SpI2223.1728-00Yn4-15c22/23oUnknown269
BLC_ECOLIP0A901
blc

yjeL

yjeLb4149 JW4110 OM lipoprotein (SEC through IM, inserted in OM by LOL), BlcOuter Membrane LipoproteinProven pignal peptidase II substrate. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 15174130PMID: 15174130 PMID: 20932056 PMID: 21541338Outer Membrane LipoproteinIN/ACell outer membrane; Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY190.216SpII1814.624Pos+2=S00Yn3-15c20/21oOuterMembrane1052
YJFN_ECOLIP0AF82
yjfN
b4188 JW5742 periplasmic protein (SEC through IM), YjfNPeriplasmicGN/APeriplasm PeriplasmicSECyesyesN200.293SpI217.51366-00Yn4-15c23/24oUnknown2104
YJFY_ECOLIP0AF86
yjfY
b4199 JW4157 periplasmic protein (SEC through IM), YjfYPeriplasmicGN/APeriplasm PeriplasmicSECyesyesY210.833SpI2015.6931-00Yn5-15c20/21oUnknown293
PSIF_ECOLIP0AFM4
psiF
b0384 JW5054 periplasmic protein (SEC through IM), Phosphate starvation-inducible PsiF Periplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY220.376SpI2113.709-10Yn5-16c21/22oUnknown244
YFIL_ECOLIP11289
yfiL
b2602 JW5412 OM lipoprotein (SEC through IM, inserted in OM by LOL), YfiLOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLyesyesY260.211SpII1612.903Pos+2=Q00Yn5-14c19/20oUnknown259
BAMC_ECOLIP0A903
bamC

dapX nlpB

dapX nlpBb2477 JW2462 OM lipoprotein (SEC through IM, inserted in OM by LOL), assembly factor BamCOuter Membrane LipoproteinOuter membrane protein related to resistance to ampicillin and tetracycline. Part of bam complex. Forms subcomplex with BamCE. Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384PMID: 16372265 PMID: 21823654 PMID: 21139201 PMID: 21370981 PMID: 15174130 PMID: 12488465 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 16079137 PMID: 20932056 PMID: 21541338Outer Membrane LipoproteinISoluble IM FractionCell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesN320.177SpII2417.2458Pos+2=S00Yn13-23c27/28oOuterMembrane1086
SLYB_ECOLIP0A905
slyB
b1641 JW1633 OM lipoprotein (SEC through IM, inserted in OM by LOL), SlyBOuter Membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384PMID: 15174130 PMID: 15911532 PMID: 10806384 PMID: 20932056 PMID: 21541338Outer Membrane LipoproteinISoluble IM FractionCell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesN220.181SpII1719.9051Pos+2=V00Yn5-16c21/22oOuterMembrane9
MIPA_ECOLIP0A908
mipA

yeaF

yeaFb1782 JW1771 OM b-barrel protein (SEC through IM, inserted in OM by BAM), MltA-interacting protein MipAOuter Membrane b-barrel proteinMipA is considered to be a structural protein mediating the assembly of MltA to PBP1B into a complexPMID: 10037771. MipA couples both enzymes to one another in vivo, it is likely to give rise to a membrane adhesion site as depicted. Such contacts between the membranes. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy 2000,Thein 2010)PMID: 15911532PMID: 10806384PMID: 12624733PMID: 20932056 PMID: 10037771PMID: 10037771 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 16079137 PMID: 20932056Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel protein (Experimental)SECBAMyesyesY230.835SpI2221.2923-00Yn6-17c22/23oOuterMembrane1011
OMPA_ECOLIP0A910
ompA

con tolG tut

con tolG tutb0957 JW0940 OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpAOuter Membrane b-barrel proteinSubstrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Potential pubstrate of periplasmic chaperones Skp. Trigger factor-sensitive aggregation. Trigger factor-sensitive aggregation. Copurifies with trigger factor in pull down assays. The Lipid Bilayer-Inserted Membrane Protein BamA of Escherichia coli Facilitates Insertion and Folding of Outer Membrane Protein A from Its Complex with Skp. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 SecA is sufficient to transport a secretory protein with hydrophobic signal sequence across SecYEG, but efficient translocation requires SRP in Addition PMID: 24717922 Disulfide bridge (311 323) Disulfide bond-containing protein PMID: 25664544PMID: 8626309 PMID: 17908933 PMID: 19343722 PMID: 19737520 PMID: 23641708 PMID: 12488465 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 9808047 PMID: 7813480 PMID: 16079137 PMID: 21778229 PMID: 20932056 PMID: 21541338 PMID: 19953543 PMID: 9298646 PMID: 24717922 PMID: 25664544Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane Outer Membrane ??-barrel protein (Experimental)TFSECSKP,SURA,DEGP,DSBABAMyesyesY220.872SpI2128.1613-00Yn5-16c21/22oOuterMembrane1010
PAL_ECOLIP0A912
pal

excC

excCb0741 JW0731 OM lipoprotein (SEC through IM), inserted in OM by LOL), PG-associated PalOuter Membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) PMID: 10806384 PMID: 9298646PMID: 15174130 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 19364805 PMID: 23193105 PMID: 20932056 PMID: 9298646Outer Membrane LipoproteinISoluble IM FractionCell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY290.5SpII2121.6668Pos+2=S00Yn6-14c18/19oOuterMembrane1081
OMPW_ECOLIP0A915
ompW

yciD

yciDb1256 JW1248 OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpWOuter Membrane b-barrel proteinOuter membrane protein related to resistance to ampicillin and tetracycline. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) PMID: 9298646PMID: 16372265 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 16414958 PMID: 20932056 PMID: 9298646Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane ??-barrel protein (Experimental)SECBAMyesyesY220.754SpI2126.4914-00Yn4-15c21/22oOuterMembrane1042
OMPX_ECOLIP0A917
ompX

ybiG

ybiGb0814 JW0799 OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpXOuter Membrane b-barrel proteinSecB substrate. Substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Outer membrane proteins OmpF, OmpC, and OmpX as central to the YebF export mechanism. Trigger factor-sensitive aggregation. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 9298646PMID: 16352602 PMID: 19343722 PMID: 22658749 PMID: 19737520 PMID: 12488465 PMID: 15911532 PMID: 10806384 PMID: 11266632 PMID: 10545325 PMID: 20932056 PMID: 21541338 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane; Multi-pass membrane proteinOuter Membrane ??-barrel protein (Experimental)SECB,TFSECSURA,SKPBAMyesyesY240.63SpI2326.0753-10Yn4-15c23/24oOuterMembrane1014
PA1_ECOLIP0A921
pldA
b3821 JW3794 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Phospholipase A1 PldAOuter Membrane b-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Potential Skp substrate PMID: 19953543 PMID: 6397464PMID: 12624733 PMID: 11266632 PMID: 10537112 PMID: 6397463 PMID: 20932056 PMID: 10806384 PMID: 19953543 PMID: 6397464Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel protein (Experimental)SECSKPBAMyesyesY210.528SpI207.74532-00Yn3-14c20/21oOuterMembrane109
YJJA_ECOLIP18390
yjjA
b4360 JW5795 periplasmic protein (SEC through IM), YjjAPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY260.86SpI2523.6068-00Yn8-19c25/26oUnknown2100
YAAI_ECOLIP28696
yaaI
b0013 JW0012 periplasmic protein (SEC through IM), UPF0412 YaaIPeriplasmicGN/APeriplasmicSECyesyesY240.727SpI239.88216-00Yn4-15c23/24oUnknown259
TSX_ECOLIP0A927
tsx

nupA

nupAb0411 JW0401 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Nucleoside-specific channel-forming Tsx Outer Membrane b-barrel proteinOuter membrane protein related to resistance to ampicillin and tetracycline. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 10806384PMID: 16372265 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 19953543Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane Outer Membrane ??-barrel protein (Experimental)SECBAMProphage TransposaseyesnoY230.882SpI2224.8185-00Yn4-14c22/23oOuterMembrane100
WZA_ECOLIP0A930
wza
b2062 JW2047 OM lipoprotein & extra-cellular peripheral OM protein (SEC through IM), inserted in OM by LOL), Putative polysaccharide export Wza Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular spaceHas a helical structure that crosses membrane. The transmembrane region of Wza is an alpha-helical barrel. Proven pignal peptidase II substrate. It has been demostrated that it can be also secreted and be surface exposed. PMID: 15174130PMCID: PMC3315050 PMID: 15174130 PMID: 10619844Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular spaceI, F4N/ACell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY260.13SpII2012.3938Pos+2=T00Yn11-21c25/26oOuterMembrane944
GFCE_ECOLIP0A932
gfcE

yccZ

yccZb0983 JW0966 OM lipoprotein (SEC through IM), inserted in OM by LOL), Putative polysaccharide export GfcE Outer Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY230.202SpII2015.093Pos+2=T00Yn10-21c26/27oOuterMembrane959
MLTA_ECOLIP0A935
mltA

mlt ygdM

mlt ygdMb2813 JW2784 OM lipoprotein (SEC through IM), inserted in OM by LOL), Membrane-bound lytic murein transglycosylase A MltAOuter Membrane LipoproteinThe formation of a complex between a murein polymerase (PBP1B) and a murein hydrolase (MltA). In the presence of MipA represents a first step in a reconstitution of the hypothetical murein-synthesizing holoenzyme. Postulated to be responsible for controlled growth of the stress-bearing sacculus of <i>E.coli</i>. Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) PMID: 15174130 SRP recognizes the first signal anchor sequence of a polytopic membrane protein (MtlA) resulting in cotranslational targeting of MtlA to SecY and phospholipids of the plasma membrane. PMID: 10619852 Possible interaction of SRP with the secretory protein pOmpA is prevented by the association of trigger factor with nascent pOmpA. PMID: 10619852PMID: 15174130 PMID: 10037771 PMID: 12624733 PMID: 20932056 PMID: 10619852Outer Membrane LipoproteinIN/ACell outer membrane; Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLpseudogene (Ochman & Davalos, 2006)noyesY200.191SpII2022.7365Pos+2=S00Yn9-19c23/24oOuterMembrane1035
YBFC_ECOLIP28915
ybfC
b0704 JW0693 periplasmic protein (SEC through IM), YbfCPrediction of three weak transmembrane helixes (one with 0.6 probability) in Phobius.PeriplasmicGN/APeriplasmicSECnoyesY200.787SpI193.48234-00Yn4-15c19/20oUnknown248
MARB_ECOLIP31121
marB
b1532 JW1525 periplasmic protein (SEC through IM), Multiple antibiotic resistance MarB PeriplasmicGN/APeriplasmicSECnoyesY220.602SpI2118.3001-00Yn4-15c21/22oUnknown260
BAME_ECOLIP0A937
bamE

smpA

smpAb2617 JW2598 OM lipoprotein (SEC through IM, inserted in OM by LOL), assembly factor BamEOuter Membrane LipoproteinPart of BAM complex. Forms subcomplex with BamCE.PMID: 21823654 PMID: 21139201 PMID: 21370981 PMID: 17404237 PMID: 20932056Outer Membrane LipoproteinISoluble IM FractionCell outer membrane Outer membrane LipoproteinSECLOLyesyesY240.197SpII1919.5033Pos+2=S00Yn5-16c20/21oOuterMembrane944
BAMA_ECOLIP0A940
bamA

yaeT yzzN yzzY

yaeT yzzN yzzYb0177 JW0172 OM b-barrel protein (SEC through IM, inserted in OM by BAM), assembly factor BamAOuter Membrane b-barrel proteinPart of bam complexPMID: 21823654PMID: 21370981. Folding of OmpA from its complex with the periplasmic chaperone Skp into bilayers composed of phosphatidylethanolamine and phosphatidylcholine was inhibited in the absence of BamA but facilitated when BamA was present, indicating an interaction of Skp-OmpA complexes with BamAPMID: 23641708. Outer membrane protein determined by 2D gel electrophoresis (PMID: 15911532,PMID: 12624733,PMID: 20932056) Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 21823654 PMID: 21370981 PMID: 19525348 PMID: 23641708 PMID: 12624733 PMID: 10806384 PMID: 16079137 PMID: 20932056 PMID: 19953543 PMID: 9298646Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane Outer Membrane ss-barrel protein(experimental)SECBAMyesyesY210.641SpI2010.5737-00Yn6-13c20/21oOuterMembrane1032
YEAY_ECOLIP0AA91
yeaY
b1806 JW1795 OM lipoprotein (SEC through IM, inserted in OM by LOL), YeaYOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesN270.138SpII2214.0614Pos+2=V00Yn10-20c25/26oOuterMembrane925
YAFK_ECOLIP0AA99
yafK
b0224 JW0214 periplasmic protein (SEC through IM), Putative L,D-transpeptidase YafK PeriplasmicGN/APeriplasmicSECyesyesY200.74SpI1910.678-10Yn4-22c27/28oUnknown225
YDEI_ECOLIP31130
ydeI
b1536 JW1529 periplasmic protein (SEC through IM), YdeIPeriplasmicGN/APeriplasmicSECnoyesY200.882SpI1913.7979-00Yn3-14c19/20oUnknown2100
YIBG_ECOLIP32106
yibG
b3596 JW3570 periplasmic protein (SEC through IM), YibGPeriplasmicGN/APeriplasmicSECnoyesY200.567SpI190.904394-00Yn3-14c19/20oUnknown218
YIIQ_ECOLIP32160
yiiQ
b3920 JW3891 periplasmic protein (SEC through IM), YiiQPeriplasmicGN/APeriplasmicSECyesyesY240.736SpI2314.7775-00Yn4-15c23/24oUnknown2
YIIX_ECOLIP32167
yiiX
b3937 JW3908 periplasmic protein (SEC through IM), YiiXPeriplasmicGN/APeriplasmicSECnoyesY190.818SpI1814.7441-00Yn5-13c18/19oUnknown227
ECPA_ECOLIP0AAA3
ecpA

matB yagZ

matB yagZb0293 JW0287 Fimbrial periplasmic protein (SEC through IM), Common pilus major fimbrillin subunit EcpAPeriplasmicPutative chaperone???usher fimbrial operon yag (class ??); Fimbrial Subunit (yagZ). PMID: 16522795PMID: 20345943 PMID: 16522795PeriplasmicGN/AFimbrium Periplasmic (Experimental)fimbriaeSECnoyesY230.863SpI2225.6343-00Yn5-15c22/23oUnknown234
YBIS_ECOLIP0AAX8
ybiS
b0819 JW0803 periplasmic peripheral OM protein (SEC through IM), Probable L,D-transpeptidase YbiSPeripheral outer membrane protein facing the periplasmPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. YbiS has been shown to crosslink Braun's lipoprotein (Lpp) to the peptidoglycan. PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350PMID: 18498364 PMID: 23832002 PMID: 9298646 PMID: 22030350Peripheral outer membrane protein facing the periplasmF3N/APeriplasmPeriplasmic (Experimental)SECSURAyesyesY250.584SpI2419.8413-10Yn8-19c24/25oUnknown240
YMBA_ECOLIP0AB10
ymbA
b0952 JW5127 IM lipoprotein (SEC through IM), inserted in OM by LOL), Intertransport PqiC YmbAputative protase (enterobacterium homolog)Inner Membrane LipoproteinEN/ACell outer membrane CytoplasmicSECLOLyesyesN200.205SpII1522.8198Pos+2=S00Yn4-14c19/20oUnknown282
EFEO_ECOLIP0AB24
efeO

ycdO

ycdOb1018 JW1003 periplasmic protein (SEC through IM), Iron uptake system component EfeO Periplasmic Identified DsbA substrate PMID: 19953543 PMID: 12107143 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544PMID: 16551627 PMID: 19953543 PMID: 12107143 PMID: 22030350 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECDSBAyesyesY270.767SpI2618.2235-00Yn9-18c26/27oPeriplasmic1042
YCEB_ECOLIP0AB26
yceB
b1063 JW1050 OM lipoprotein (SEC through IM, inserted in OM by LOL), YceBOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinISoluble IM FractionCell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesN550.134SpII1816.4921Pos+2=N00Yn4-15c19/20oUnknown245
YIJF_ECOLIP32668
yijF
b3944 JW3916 periplasmic protein (SEC through IM), YijFPeriplasmicGN/APeriplasmicSECyesyesY190.257SpI2011.5911-00Yn3-14c18/19oUnknown214
YJBG_ECOLIP32688
yjbG
b4028 JW3988 periplasmic protein (SEC through IM), YjbGPeriplasmicGN/APeriplasmicSECyesyesY210.827SpI2017.0485-00Yn5-15c20/21oCytoplasmicMembrane9
YEHE_ECOLIP33344
yehE
b2112 JW2099 periplasmic protein (SEC through IM), YehEPeriplasmicYeh operon is homolog to fim operon (yehd is fimI homolog).PMID: 20345943PeriplasmicGN/APeriplasmicSECnoyesY230.529SpI2211.8793-00Yn6-17c22/23oCytoplasmicMembrane949
LPOB_ECOLIP0AB38
lpoB

ycfM

ycfMb1105 JW5157 OM lipoprotein (SEC through IM), inserted in OM by LOL), Penicillin-binding activator LpoB Outer Membrane LipoproteinThe two OM Lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase activity, thereby facilitating attachment of new peptidoglycans to the PG sacculus. Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 21183073 PMID: 21183074 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY240.258SpII1923.7759Pos+2=V00Yn8-18c22/23oUnknown296
BHSA_ECOLIP0AB40
bhsA

comC ycfR

comC ycfRb1112 JW1098 periplasmic peripheral OM protein (SEC through IM), Multiple stress resistance BhsA Peripheral outer membrane protein facing the periplasmBy membrane fractionation, ComC was shown to be localized in the outer membrane.PMID: 22089859Peripheral outer membrane protein facing the periplasmF3N/ACell outer membrane PeriplasmicSECyesyesY230.773SpI2221.6297-00Yn6-14c22/23oUnknown270
APBE_ECOLIP0AB85
apbE

yojK yojL

yojK yojLb2214 JW5368 IM lipoprotein (SEC through IM), inserted in OM by LOL), FAD:FMN transferase ApbEInner Membrane LipoproteinProven signal peptidase II substrate.PMID: 15174130Inner Membrane LipoproteinEIM (predicted)Cell inner membrane Inner membrane lipoproteinSECLOLyesyesN280.154SpII1912.0176Pos+2=D00Yn8-18c22/23oUnknown265
CSGB_ECOLIP0ABK7
csgB
b1041 JW1024 Curli related extra-cellular peripheral OM protein (SEC through IM), secreted over OM by curli), Minor curlin subunit CsgBPeripheral outer membrane protein facing the extra-cellular spaceCurli component. CsgB localization requires at least one component of the curli secretion apparatus, CsgF. Curli are a functional amyloid whose in vivo polymerization requires a dedicated nucleator protein, CsgB, and an assembly protein, CsgF. Without CsgF, curli subunits are released from the cell into the media and are inefficiently polymerized, resulting in fewer and mislocalized curli fibers. PMID: 19131513 PMID: 9383186 PMID: 9312041PMID: 16704339 PMCID: PMC2630086 PMID: 21645131 PMID: 19131513 PMID: 9383186 PMID: 9312041Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbrium Cell surface appendage (Experimental)CurliSECCurliyesyesY220.53SpI2116.29-00Yn5-13c21/22oExtracellular9
PPDA_ECOLIP33554
ppdA
b2826 JW2794 periplasmic protein (SEC through IM), Prepilin peptidase-dependent A PpdAPeriplasmicGN/APeriplasmicSECyesyesN270.172TMH07.10154-11Ni12-33oCytoplasmicMembrane910
YBBC_ECOLIP33668
ybbC
b0498 JW0487 OM lipoprotein (SEC through IM, inserted in OM by LOL), YbbCOuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLnoyesY180.367SpII178.97285Pos+2=N00Yn6-17c25/26oUnknown248
ASR_ECOLIP36560
asr
b1597 JW5826 periplasmic protein (SEC through IM), Acid shock protein AsrPeriplasmicPMID: 12670971PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY220.907SpI2128.9272-00Yn4-15c21/22oPeriplasmic10
YBCH_ECOLIP37325
ybcH
b0567 JW0556 periplasmic protein (SEC through IM), YbcHPeriplasmicGN/APeriplasmicSECnoyesY210.6SpI2014.6445-10Yn4-15c20/21oCytoplasmicMembrane926
NRFA_ECOLIP0ABK9
nrfA
b4070 JW4031 periplasmic protein (SEC through IM), Cytochrome c-552 NrfAPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 793493 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY270.665SpI2614.744-00Yn11-21c26/27oPeriplasmic1025
NRFB_ECOLIP0ABL1
nrfB

yjcI

yjcIb4071 JW4032 periplasmic protein (SEC through IM), Cytochrome c-type NrfBPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 15280383 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECnoyesY330.498SpI256.62799-00Yn7-18c23/24oPeriplasmic916
NAPB_ECOLIP0ABL3
napB

yejY

yejYb2203 JW5367 periplasmic protein (SEC through IM), nitrate reductase, electron transfer subunit NapBPeriplasmic Nitrate reductase, napFDAGHBC, is located in the periplasm. E. coli also expresses two membrane-bound proton-translocating nitrate reductases, encoded by the narGHJI and narZYWV operons. PMID: 11844760 PMID: 10234835 Disulfide bond-containing protein PMID: 25664544PMID: 10234835 PMID: 10548535 PMID: 17130127 PMID: 11844760 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY280.825SpI2714.6891-00Yn9-20c27/28oPeriplasmic10
SFMA_ECOLIP0ABW5
sfmA
b0530 JW0519 Fimbrial periplasmic protein (SEC through IM), SfmAPeriplasmicPotential fimbrial sfm operon (class ??1); Fimbrial Subunit. Disulfide bridge (41 81) PMID: 19820722 PMID: 20345943 PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECCUyesyesY230.832SpI2221.4596-00Yn6-17c22/23oExtracellular1083
SURA_ECOLIP0ABZ6
surA
b0053 JW0052 periplasmic protein (SEC through IM), Chaperone SurAPeriplasmicPMID: 21370981 PMID: 19525348 PMID: 9298646 PMID: 22030350 PMID: 14506253PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY210.795SpI2015.5107-00Yn7-15c20/21oPeriplasmic1086
YTFJ_ECOLIP39187
ytfJ
b4216 JW4175 periplasmic protein (SEC through IM), YtfJPeriplasmicPMID: 9298646PeriplasmicGN/APeriplasm Periplasmic(experimental)SECyesyesY210.734SpI2013.6826-00Yn6-14c22/23oUnknown218
YQJC_ECOLIP42616
yqjC
b3097 JW5516 periplasmic protein (SEC through IM), YqjCPeriplasmicGN/APeriplasmicSECyesyesY210.508SpI209.52426-00Yn5-15c20/21oUnknown279
YHCE_ECOLIP45421
yhcE
b4569 b3217Fimbrial periplasmic protein (SEC through IM), Putative YhcEPeriplasmicPotential fimbrial yhc operon (class ??); Uknown function.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECpseudogene (Uniprot)nonoY200.69SpI194.02903-00Yn4-11c16/17oUnknown220
BAMD_ECOLIP0AC02
bamD

yfiO

yfiOb2595 JW2577 OM lipoprotein (SEC through IM, inserted in OM by LOL), assembly factor BamDOuter Membrane LipoproteinPart of bam complex. Forms subcomplex with BamCE. Outer membrane protein related to resistance to ampicillin and tetracycline. YfiO stabilizes the YaeT complex and is essential for outer membrane protein assembly in Escherichia coli. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 16372265PMID: 16372265 PMID: 15174130 PMID: 16824102 PMID: 21823654 PMID: 21139201 PMID: 21370981 PMID: 12488465 PMID: 15911532 PMID: 16079137 PMID: 20932056Outer Membrane LipoproteinISoluble IM FractionCell outer membrane Outer membrane Lipoprotein(experimental)SECLOLyesyesY240.171SpII1927.0165Pos+2=S00Yn7-17c22/23oOuterMembrane1022
IVY_ECOLIP0AD59
ivy

ykfE

ykfEb0220 JW0210 periplasmic protein (SEC through IM), Inhibitor of vertebrate lysozyme IvyPeriplasmicExperimentally verified gene-product. Verified that the signal peptide is cleaved. PMID: 11278658 Disulfide bridge (85 90) Disulfide bond-containing protein PMID: 25664544PMID: 9868784 PMID: 11278658 PMID: 25664544PeriplasmicGSoluble IM FractionPeriplasmPeriplasmic (Experimental)SECyesyesY290.849SpI2816.6514-00Yn13-23c28/29oPeriplasmic1027
LIVJ_ECOLIP0AD96
livJ
b3460 JW3425 periplasmic protein (SEC through IM), Leu/Ile/Val-binding LivJPeriplasmicSubstrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 Disulfide bridge (76 101) Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 19953543 PMID: 9298646 PMID: 22030350 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY240.832SpI2320.6668-00Yn7-18c23/24oPeriplasmic1096
TESA_ECOLIP0ADA1
tesA

apeA pldC

apeA pldCb0494 JW0483 periplasmic protein (SEC through IM), Thioesterase 1/protease 1/lysophospholipase L1 TesAPeriplasmicPMID: 8098033PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECnoyesN270.484SpI2611.0906-10Yn12-22c26/27oPeriplasmic1040
YHCF_ECOLIP45422
yhcF
b3219 JW3188 Fimbrial periplasmic protein (SEC through IM), YhcFPeriplasmicPotential fimbrial yhc operon (class ??); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY210.835SpI2016.471-00Yn6-16c20/21oUnknown27
YAJI_ECOLIP46122
yajI
b0412 JW5056 OM lipoprotein (SEC through IM, inserted in OM by LOL), YajIOuter Membrane LipoproteinIN/ACell membrane Outer membrane LipoproteinSECLOLnoyesY240.215SpII1918.9902Pos+2=V00Yn8-18c23/24oUnknown288
YFIM_ECOLIP46126
yfiM
b2586 JW2570 IM lipoprotein (SEC through IM, inserted in OM by LOL), YfiMContains the following signature IPR018736 Protein of unknown function DUF2279,Periplasmic lipoproteinInner Membrane LipoproteinEN/ACytoplasmicSECLOLyesyesY200.599SpII1415.2395Pos+2=S00Yn3-13c18/19oCytoplasmicMembrane912
NLPD_ECOLIP0ADA3
nlpD
b2742 JW2712 OM lipoprotein (SEC through IM), inserted in OM by LOL), Murein hydrolase activator NlpD Outer Membrane LipoproteinProven signal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell inner membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY250.134SpII2521.9047Pos+2=S00Yn13-24c29/30oOuterMembrane985
YAJG_ECOLIP0ADA5
yajG
b0434 JW0424 OM lipoprotein (SEC through IM, inserted in OM by LOL), YajGOuter Membrane LipoproteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 9298646PMID: 15911532 PMID: 20932056 PMID: 9298646Outer Membrane LipoproteinISoluble IM FractionCell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY200.403SpII1719.0402Pos+2=A00Yn5-15c19/20oUnknown2
OSME_ECOLIP0ADB1
osmE

anr

anrb1739 JW1728 OM lipoprotein (SEC through IM), inserted in OM by LOL), Osmotically-inducible putative OsmE Outer Membrane LipoproteinProven signal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384 Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 15911532 PMID: 20932056 PMID: 21541338 PMID: 10806384 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionCell inner membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY240.207SpII2020.0226Pos+2=T10Yn7-18c23/24oUnknown298
ECNB_ECOLIP0ADB7
ecnB

yjeU

yjeUb4411 JW4108 OM lipoprotein (SEC through IM), inserted in OM by LOL), Entericidin B EcnBOuter Membrane LipoproteinPotentially toxic protein. Proven pignal peptidase II substrate. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 15174130PMID: 15174130 PMID: 19121005 PMID: 20932056 PMID: 21541338Outer Membrane LipoproteinISoluble IM FractionCell membrane; Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLnoyesY220.27SpII2117.5085Pos+2=N10Yn5-15c20/21oCytoplasmicMembrane10
LPTE_ECOLIP0ADC1
lptE

rlpB

rlpBb0641 JW0636 OM lipoprotein (SEC through IM), inserted in OM by LOL), LPS-assembly LptE Outer Membrane LipoproteinProven signal peptidase II substrate. PMID: 16861298PMID: 15174130 PMID: 20932056 PMID: 16861298 PMID: 22901060Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesN250.125SpII1817.3262Pos+2=G00Yn4-15c20/21oOuterMembrane1080
YGGM_ECOLIP46142
yggM
b2956 JW2923 periplasmic protein (SEC through IM), YggMPeriplasmicGN/APeriplasmicSECyesyesY220.874SpI2116.8631-00Yn5-16c21/22oPeriplasmic932
YFJT_ECOLIP52135
yfjT
b2637 JW2618 periplasmic protein (SEC through IM), YfjTPeriplasmicGN/APeriplasmicSECProphage Integrase (EcoGene)nonoY240.673SpI2319.2157-00Yn9-19c23/24oUnknown222
TAMA_ECOLIP0ADE4
tamA

yftM ytfM

yftM ytfMb4220 JW4179 OM b-barrel protein (SEC through IM, inserted in OM by BAM and TAM), Translocation and assembly module subunit TamAOuter Membrane b-barrel proteinPart of the translocation and assembly module (TAM). TAM system promotes efficient secretion of autotransporters in proteobacteria.PMID: 17214547 PMID: 22466966Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinSECBAMyesyesY220.861SpI2111.5811-00Yn7-15c21/22oOuterMembrane10
YIAF_ECOLIP0ADK0
yiaF
b3554 JW5655 IM lipoprotein (SEC through IM, inserted in OM by LOL), YiaFUncharacterized protein yiaF - echolocation Occurrence of signal peptide determined by LipoP signal sequence shown based upon lipoP, not possible to determine which membrane based on +2 amino acid rule.Inner Membrane LipoproteinESoluble IM FractionMembrane LipoproteinSECLOLyesyesN280.132SpII2510.3533Pos+2=F10Yn10-21c26/27oUnknown267
YIFL_ECOLIP0ADN6
yifL
b4558 JW3781 OM lipoprotein (SEC through IM, inserted in OM by LOL), YifLOuter Membrane LipoproteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 16397293PMID: 15911532 PMID: 16397293Outer Membrane LipoproteinISoluble IM FractionCell membrane Membrane Lipoprotein (Experimental)SECLOLnoyesY240.159SpII1927.2584Pos+2=G10Yn7-18c23/24oUnknown2
YGGN_ECOLIP0ADS9
yggN
b2958 JW2925 periplasmic protein (SEC through IM), YggNPeriplasmicSubstrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 14726535PMID: 14726535 PMID: 19953543PeriplasmicGN/APeriplasmic(experimental)SECDSBAyesyesY210.797SpI2021.2471-00Yn6-16c20/21oUnknown280
MLAC_ECOLIP0ADV7
mlaC

yrbC

yrbCb3192 JW3159 periplasmic protein (SEC through IM), Interphospholipid transport system binding MlaC PeriplasmicPMID: 15911532PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECnoyesY220.509SpI2114.0896-00Yn8-16c21/22oUnknown261
YNBE_ECOLIP64448
ynbE
b1382 JW1377 OM lipoprotein (SEC through IM, inserted in OM by LOL), YnbEOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLnoyesN250.214SpII164.04646Pos+2=T00Yn4-15c24/25oUnknown2
YNCJ_ECOLIP64459
yncJ
b1436 JW1432 periplasmic protein (SEC through IM), YncJPeriplasmicGN/APeriplasmicSECnoyesY230.752SpI228.63896-00Yn5-16c22/23oUnknown238
YOAF_ECOLIP64493
yoaF
b1793 JW1782 OM lipoprotein (SEC through IM, inserted in OM by LOL), YoaFOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLnoyesY240.245SpII1620.7594Pos+2=S00Yn4-15c23/24oUnknown290
YEBY_ECOLIP64506
yebY
b1839 JW1828 periplasmic protein (SEC through IM), YebYPeriplasmic Identified DsbA substrate PMID: 19953543PMID: 19953543PeriplasmicGN/APeriplasmicSECDSBAyesyesY210.862SpI2019.6801-10Yn5-12c20/21oUnknown235
ACRA_ECOLIP0AE06
acrA

lir mtcA

lir mtcAb0463 JW0452 IM lipoprotein (SEC through IM), inserted in OM by LOL), Multidrug efflux pump subunit AcrA Inner Membrane LipoproteinProven signal peptidase II substrate. PMID: 10894736PMID: 15174130 PMID: 15228545 PMID: 16079137 PMID: 10894736Inner Membrane LipoproteinESoluble IM FractionCell inner membrane Inner membrane lipoprotein (Experimental)SECLOLyesyesY220.194SpII2419.636Pos+2=D00Yn6-16c21/22oCytoplasmicMembrane1064
APHA_ECOLIP0AE22
aphA

napA yjbP

napA yjbPb4055 JW4015 periplasmic protein (SEC through IM), Class B acid phosphatase AphAPeriplasmicPMID: 9011040 PMID: 9298646PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECnoyesY260.643SpI2514.5914-00Yn7-17c25/26oUnknown2
CPXP_ECOLIP0AE85
cpxP

yiiO

yiiOb4484 JW5558 periplasmic peripheral IM protein (SEC through IM), CpxP Peripheral inner membrane protein facing the periplasmPMID: 17904518 PMID: 10972835 PMID: 21317318Peripheral inner membrane protein facing the periplasmF2N/APeriplasm Membrane associated (Experimental)SECpseudogene (Ochman & Davalos, 2006)yesyesY220.806SpI2116.0374-00Yn3-14c21/22oPeriplasmic10104
CSGE_ECOLIP0AE95
csgE
b1039 JW1022 Curli related periplasmic protein (SEC through IM), Curli production assembly/transport component CsgEPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Curli secretion specificity factor. CsgE provides substrate specificity to the curli secretion pore CsgG, and acts directly on the secretion substrate CsgA to prevent premature subunit assembly. PMID: 9928475PMID: 16704339 PMID: 18498364 PMID: 21645131 PMID: 19131513 PMID: 9928475PeriplasmicGN/APeriplasmic (Experimental)CurliSECSURAyesyesY230.789SpI223.89784-00Yn7-17c22/23oUnknown215
CSGF_ECOLIP0AE98
csgF
b1038 JW1021 Curli related extra-cellular peripheral OM protein (SEC through IM), secreted over OM by curli), Curli production assembly/transport component CsgFPeripheral outer membrane protein facing the extra-cellular spaceCurli component. CsgF is secreted to the cell surface, where it mediates the cell-association and protease-resistance of the CsgB nucleator, suggesting that CsgF is required for specific localization and/or chaperoning of CsgB for full nucleator activity. Curli are a functional amyloid whose in vivo polymerization requires a dedicated nucleator protein, CsgB, and an assembly protein, CsgF. Without CsgF, curli subunits are released from the cell into the media and are inefficiently polymerized, resulting in fewer and mislocalized curli fibers. PMID: 19131513 PMID: 9928475PMID: 16704339 PMID: 16522795 PMID: 21645131 PMID: 19131513 PMID: 9928475Peripheral outer membrane protein facing the extra-cellular spaceF4N/ACell outer membrane Periplasmic (Experimental)CurliSECCurliyesyesY200.853SpI1913.9164-10Yn6-14c19/20oExtracellular930
RCNB_ECOLIP64534
rcnB

yohN

yohNb2107 JW5346 periplasmic protein (SEC through IM), Nickel/cobalt homeostasis RcnB PeriplasmicPMID: 21665978PeriplasmicGN/APeriplasm PeriplasmicSECnoyesY220.81SpI2123.7077-10Yn8-16c21/22oUnknown279
YPEC_ECOLIP64542
ypeC
b2390 JW2387 periplasmic protein (SEC through IM), YpeCPeriplasmicGN/APeriplasmicSECnoyesY220.729SpI2114.9819-00Yn4-15c21/22oUnknown214
YFIR_ECOLIP64548
yfiR
b2603 JW2584 periplasmic protein (SEC through IM), YfiRPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasm PeriplasmicSECyesyesY230.684SpI2213.4131-00Yn7-17c22/23oUnknown621
CSGG_ECOLIP0AEA2
csgG
b1037 JW1020 Curli related OM lipoprotein & extra-cellular peripheral OM protein (SEC through IM), inserted in OM by LOL), Curli production assembly/transport component CsgGOuter Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular spaceCurli component. Proven signal peptidase II substrate. CsgG is an outer membrane protein required for the secretion of the two curli structural subunits CsgA and CsgB. CsgG is a lipoprotein that spans the outermembrane and assembles into an oligomeric annular-shaped structure with an inner diameter of approximately 2 nm (Margery L. Evans and Matthew R. Chapman in press). Overexpression of CsgG results in increased sensitivity to the small antibiotic erythromycin (740Da) but not the larger vancomycin (1440Da) suggesting that CsgG has a pore-like activity (Robinson et al 2006). PMID: 15174130PMID: 16704339 PMID: 15174130 PMID: 21645131 PMID: 16420357 PMID: 19131513Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular spaceI, F4N/ACell membrane Outer membrane Lipoprotein (Experimental)CurliSECLOLyesyesY200.544SpII1512.9163Pos+2=L00Yn4-13c18/19oCytoplasmicMembrane944
DACA_ECOLIP0AEB2
dacA

pfv

pfvb0632 JW0627 periplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine carboxypeptidase DacAPeripheral inner membrane protein facing the periplasmAnchored to inner membrane by C-terminal tailPMID: 2194801. Using natural isotope abundance NMR, the structure of the PBP 5 anchor peptide within a micelle was determinedPMID: 20192190. The structure conforms to a helix-bend-helix-turn-helix motif and reveals that the anchor enters the membrane so as to form an amphiphilic structure within the interface of the hydrophilic/hydrophobic boundary regions near the lipid head groups. PBP-5 deletion mutants exhibit irregular distribution of MreB at the deformed zones PMID: 20545860. PMID: 3279397 PMID: 8424800 DacA(PBP-5) anchors to the periplasmic face of the inner membrane via C-terminal amphiphilic alpha-helix. The Alpha-helical conformation in the C-terminal anchoring domain is observed in aqueous solution or in the presence of phospholipid vesicles. A pH dependent loss of alpha-helical conformation in the peptide corresponding to the PBP5 C-terminus was found to correlate with the susceptibility of PBP5 to membrane extraction. PMID: 9371419PMID: 2194801 PMID: 20192190 PMID: 20545860 PMID: 24057063 PMID: 3279397 PMID: 8424800 PMID: 9371419Peripheral inner membrane protein facing the periplasmF2Soluble IM FractionCell inner membrane; Peripheral membrane protein; Cytoplasmic side Membrane anchored (Experimental)SECyesyesY300.737SpI2917.6151-00Yn13-24c29/30oCytoplasmicMembrane98
DCRB_ECOLIP0AEE1
dcrB

yhhR

yhhRb3472 JW5682 IM lipoprotein (SEC through IM, inserted in OM by LOL), DcrBInner Membrane LipoproteinPMID: 12558182 PMID: 15911532Inner Membrane LipoproteinESoluble IM FractionPeriplasmInner membrane lipoproteinSECLOLyesyesN300.169SpII1921.1Pos+2=D00Yn8-15c20/21oPeriplasmic10100
YHCN_ECOLIP64614
yhcN
b3238 JW5540 periplasmic protein (SEC through IM), YhcNPeriplasmicGN/APeriplasm PeriplasmicSECyesyesY230.834SpI2222.7033-00Yn7-18c22/23oUnknown2
YHDV_ECOLIP64622
yhdV
b3267 JW3235 OM lipoprotein (SEC through IM, inserted in OM by LOL), YhdVOuter Membrane LipoproteinProven signal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIIM (predicted)Cell membrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesY210.268SpII1614.2179Pos+2=A11Yn4-15c20/21o50-71iUnknown230
YHFL_ECOLIP64627
yhfL
b3369 JW3332 OM lipoprotein (SEC through IM, inserted in OM by LOL), YhfLOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 21890895Outer Membrane LipoproteinIN/AMembrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesN220.162SpII1915.9797Pos+2=T00Yn7-17c22/23oUnknown2
DEGS_ECOLIP0AEE3
degS

hhoB htrH

hhoB htrHb3235 JW3204 periplasmic protein (SEC through IM), Serine endoprotease DegS Periplasmic Proteolysis of transmembrane and cytoplasmic portions of RseA by DegS frees the sigma(E) transcription factor. RseB protein, a known negative regulator, inhibits proteolysis by DegS in vitro by binding tightly to the periplasmic domain of RseA. PMID: 17360428PMID: 11442831 PMID: 17360428PeriplasmicGSoluble IM FractionCell inner membrane Membrane anchoredSECyesyesN280.167SpI284.49468-10Yn9-20c28/29oPeriplasmic975
DGAL_ECOLIP0AEE5
mglB

GBP

GBPb2150 JW2137 periplasmic protein (SEC through IM), D-galactose-binding periplasmic MglBPeriplasmic Potential Skp substrate PMID: 19953543 PMID: 7012152 PMID: 9298646PMID: 19953543 PMID: 7012152 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSKPnoyesY240.861SpI2323.7963-10Yn5-16c23/24oPeriplasmic1075
DSBA_ECOLIP0AEG4
dsbA

dsf ppfA

dsf ppfAb3860 JW3832 periplasmic protein (SEC through IM), Thiol:disulfide interchange DsbA PeriplasmicPeriplasmic disulfide isomerase DsbC cooperates with SurA and the thiol oxidase DsbA in the folding of the essential ??-barrel protein LptD. DsbA is co-translationally translocated through Sec translocon. PMID: 9298646 DsbA, is a substrate for the SRP pathway. PMID: 15838024 DsbA, is a substrate for the SRP pathway. PMID: 13129941 Disulfide bridge (49 52) PMID: 9300489 Disulfide bond-containing protein PMID: 25664544PMID: 18406599 PMID: 20615876 PMID: 19525348 PMID: 13129941 PMID: 15838024 PMID: 9298646 PMID: 9300489 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SRP (exp)SECyesyesY200.75SpI1916.7987-00Yn4-15c19/20oPeriplasmic1071
DSBC_ECOLIP0AEG6
dsbC

xprA

xprAb2893 JW2861 periplasmic protein (SEC through IM), Thiol:disulfide interchange DsbC PeriplasmicPeriplasmic disulfide isomerase DsbC cooperates with SurA and the thiol oxidase DsbA in the folding of the essential ??-barrel protein LptD. PMID: 9298646 Disulfide bridge (118 121;161 183) PMID: 10700276 Disulfide bond-containing protein PMID: 25664544PMID: 18406599 PMID: 20615876 PMID: 8168498 PMID: 9298646 PMID: 10700276 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY210.778SpI2021.5074-00Yn4-15c20/21oPeriplasmic1082
YAAX_ECOLIP75616
yaaX
b0005 JW0004 periplasmic protein (SEC through IM), YaaXPeriplasmicGN/APeriplasmicSECnoyesY240.841SpI2319.693-10Yn6-17c23/24oUnknown277
RCLB_ECOLIP75687
rclB

ykgI

ykgIb0303 JW5039 periplasmic protein (SEC through IM), RclBPeriplasmicGN/APeriplasm PeriplasmicSECnoyesY230.662SpI2216.2846-00Yn6-17c22/23oUnknown2
YAHO_ECOLIP75694
yahO
b0329 JW0321 periplasmic protein (SEC through IM), YahOPeriplasmicGN/APeriplasm PeriplasmicSECnoyesY220.85SpI2113.1005-00Yn8-16c21/22oUnknown285
FEPB_ECOLIP0AEL6
fepB
b0592 JW0584 periplasmic protein (SEC through IM), Ferrienterobactin-binding periplasmic protein FepBPeriplasmicPMID: 10986237PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY270.581SpI2613.3736-00Yn10-21c26/27oPeriplasmic1030
FLIY_ECOLIP0AEM9
fliY

yzzR

yzzRb1920 JW1905 periplasmic protein (SEC through IM), L-cystine-binding FliY PeriplasmicPMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesN300.555SpI2910.7798-00Yn10-21c29/30oPeriplasmic1096
GLNH_ECOLIP0AEQ3
glnH
b0811 JW0796 periplasmic protein (SEC through IM), Glutamine-binding periplasmic GlnHPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350PMID: 18498364 PMID: 9298646 PMID: 22030350PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECSURAyesyesY230.851SpI2219.9168-00Yn7-18c22/23oPeriplasmic1062
HDEA_ECOLIP0AES9
hdeA

yhhC yhiB

yhhC yhiBb3510 JW3478 periplasmic protein (SEC through IM), Acid stress chaperone HdeAPeriplasmicExperimentally verified gene-product. Verified that the signal peptide is cleaved. Falls into an unstructured form that is essential for its chaperone activity. The protein is dimeric at neutral pH but dissociates into a partially unfolded monomer at pH 2.0 PMID: 20080625. PMID: 8455549 Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 Disulfide bridge (39 87) Disulfide bond-containing protein PMID: 25664544PMID: 9868784 PMID: 10623550 PMID: 17085547 PMID: 20080625 PMID: 8455549 PMID: 25403562 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECYfgMyesyesY220.698SpI2116.385-10Yn4-15c21/22oUnknown2108
CHIQ_ECOLIP75734
chiQ

ybfN

ybfNb0682 JW0668 OM lipoprotein (SEC through IM, inserted in OM by LOL), ChiQOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY190.487SpII1619.5262Pos+2=A00Yn4-14c18/19oUnknown277
GFCC_ECOLIP75883
gfcC

ymcB

ymcBb0985 JW0968 periplasmic protein (SEC through IM), GfcCPeriplasmicGN/APeriplasmicSECyesyesY230.723SpI228.45245-00Yn4-15c22/23oUnknown241
YMDA_ECOLIP75917
ymdA
b1044 JW1031 periplasmic protein (SEC through IM), YmdAPeriplasmicGN/APeriplasmicSECnoyesY230.463SpI2213.2508-10Yn11-22c28/29oExtracellular936
YCFL_ECOLIP75946
ycfL
b1104 JW1090 OM lipoprotein (SEC through IM, inserted in OM by LOL), YcfLOuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLnoyesY240.214SpII1819.4253Pos+2=R00Yn5-16c21/22oUnknown270
HDEB_ECOLIP0AET2
hdeB

yhhD yhiC

yhhD yhiCb3509 JW5669 periplasmic protein (SEC through IM), Acid stress chaperone HdeBPeriplasmicExperimentally verified gene-product. Verified that the signal peptide is cleaved. PMID: 8455550 Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562 Disulfide bond-containing protein PMID: 25664544PMID: 9868784 PMID: 17085547 PMID: 8455550 PMID: 25403562 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECYfgMyesyesY300.837SpI2916.8932-00Yn10-21c29/30oUnknown263
HISJ_ECOLIP0AEU0
hisJ
b2309 JW2306 periplasmic protein (SEC through IM), Histidine-binding periplasmic HisJPeriplasmicSubstrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bridge (60 67) Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 19953543 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY230.792SpI2220.7158-10Yn4-14c22/23oPeriplasmic10
SKP_ECOLIP0AEU7
skp

hlpA ompH

hlpA ompHb0178 JW0173 periplasmic protein (SEC through IM), Chaperone SkpPeriplasmicFolding of OmpA from its complex with the periplasmic chaperone Skp into bilayers composed of phosphatidylethanolamine and phosphatidylcholine was inhibited in the absence of BamA but facilitated when BamA was present, indicating an interaction of Skp-OmpA complexes with BamA. PMID: 2167239 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350PMID: 21370981 PMID: 19525348 PMID: 23641708 PMID: 2318304 PMID: 1838129 PMID: 8730870 PMID: 2167239 PMID: 9298646 PMID: 22030350PeriplasmicGN/APeriplasm Periplasmic(experimental)SECyesyesY210.881SpI2022.0906-00Yn4-15c20/21oPeriplasmic1048
MALE_ECOLIP0AEX9
malE
b4034 JW3994 periplasmic & peripheral IM protein (SEC through IM), Maltose/maltodextrin-binding periplasmic MalEPeripheral inner membrane protein facing the periplasm, periplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. MalE is maintained in an unfolded conformation by the cytoplasmic chaperone SecB. Potential Skp substrate PMID: 19953543 PMID: 9298646 An amber mutation in the secA gene of Escherichia coli causes a pleiotropic decrease in the synthesis of secreted proteins. PMID: 3009404 Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 18498364 PMID: 1989077 PMID: 19953543 PMID: 9298646 PMID: 3009404 PMID: 25403562Peripheral inner membrane protein facing the periplasm, periplasmicF2, GN/APeriplasm Periplasmic (Experimental)SecBSECSURA,SKP,YfgMyesyesY270.712SpI2617.3972-00Yn9-17c26/27oPeriplasmic1096
YCGJ_ECOLIP76001
ycgJ
b1177 JW1166 periplasmic protein (SEC through IM), YcgJPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY230.404SpI228.58297-00Yn6-16c24/25oUnknown277
YDBL_ECOLIP76076
ydbL
b1383 JW5216 periplasmic protein (SEC through IM), YdbLPeriplasmicGN/APeriplasmicSECyesyesY220.838SpI2115.5115-10Yn4-15c21/22oUnknown251
MLTD_ECOLIP0AEZ7
mltD

dniR yafG

dniR yafGb0211 JW5018 OM lipoprotein (SEC through IM), inserted in OM by LOL), Membrane-bound lytic murein transglycosylase D MltDOuter Membrane LipoproteinProven signal peptidase II substrate. PMID: 15174133PMID: 15174130 PMID: 15174133Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesN270.22SpII1518.5563Pos+2=Q00Yn5-13c18/19oUnknown229
YJCO_ECOLIP0AF56
yjcO
b4078 JW4039 periplasmic protein (SEC through IM), Sel1-repeat-containing YjcO Periplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY180.752SpI1713.9637-00Yn4-13c17/18oUnknown282
YJEI_ECOLIP0AF70
yjeI
b4144 JW5736 OM lipoprotein (SEC through IM, inserted in OM by LOL), YjeIOuter Membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002) PMID: 15174130PMID: 15174130 PMID: 12488465 PMID: 20932056Outer Membrane LipoproteinISoluble IM FractionOuter membrane Lipoprotein (Experimental)SECLOLyesyesY280.443SpII1820.5638Pos+2=S00Yn6-17c22/23oUnknown287
NLPI_ECOLIP0AFB1
nlpI

yhbM

yhbMb3163 JW3132 OM lipoprotein (SEC through IM, inserted in OM by LOL), NlpIOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130 Induction of NlpI inhibits nucleoid division and halts cell growth. Elevation of NlpI expression enhances the transcription and the outer membrane localization of the heat shock protein IbpA and IbpB. NlpI physically interacts with IbpB. The C-terminus of NlpI is critical for the enhancement in IbpA and IbpB production, and the N-terminus of NlpI is required for the outer membrane localization of NlpI, IbpA, and IbpB. PMID: 25699035PMID: 15174130 PMID: 25699035Outer Membrane LipoproteinIN/ACell membrane; Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesN260.209SpII1814.4676Pos+2=S00Yn8-19c31/32oCytoplasmicMembrane1056
OSMY_ECOLIP0AFH8
osmY
b4376 JW4338 periplasmic & extra-cellular protein (SEC through IM), Osmotically-inducible Y OsmYPeriplasmic, Extra-cellular The most efficient excreting fusion partner, OsmY, was used as a carrier protein to excrete heterologous proteins into the medium. PMID: 18727129 The OsmY protein is an Escherichia coli 20 kDa outer membrane or periplasmic protein that is expressed in response to a variety of stress conditions, in particular, helping to provide protection against osmotic shock. One hypothesis is that OsmY prevents shrinkage of the cytoplasmic compartment by contacting the phospholipid interfaces surrounding the periplasmic space. The domain architecture of two BON domains alone suggests that these domains contact the surfaces of phospholipids, with each domain contacting a membrane PMID: 12175925PMID: 1317380 PMID: 9298646 PMID: 18727129 PMID: 12878000Periplasmic, Extra-cellularG, XN/APeriplasmPeriplasmic (Experimental)SECyesyesY290.787SpI2823.4143-00Yn12-23c28/29oPeriplasmic10108
YNCH_ECOLIP76118
yncH
b1455 JW5235 periplasmic protein (SEC through IM), YncHPeriplasmicGIM (predicted)CytoplasmicSECnoyesN400.113CYT0-0.200913-00Yn2-13c18/19oUnknown235
RZPQ_ECOLIP76158
rzpQ

ydfP

ydfPb1553 JW1545 periplasmic protein (SEC through IM), RzpQPeriplasmicGN/APeriplasmicSECProphage Integrase (EcoGene)nonoN230.245SpI220.491707-10Yn7-17c22/23oUnknown219
PBP7_ECOLIP0AFI5
pbpG

yohB

yohBb2134 JW5355 periplasmic protein (SEC through IM), D-alanyl-D-alanine endopeptidase PbpGPeriplasmicPMID: 7721700PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY260.58SpI2517.1021-00Yn6-17c25/26oPeriplasmic1082
POTD_ECOLIP0AFK9
potD
b1123 JW1109 periplasmic protein (SEC through IM), Spermidine/putrescine-binding periplasmic PotDPeriplasmic Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350PMID: 1939142 PMID: 9298646 PMID: 22030350PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY240.865SpI2325.0348-00Yn8-18c23/24oPeriplasmic10
PPIA_ECOLIP0AFL3
ppiA

rot rotA

rot rotAb3363 JW3326 periplasmic protein (SEC through IM), Peptidyl-prolyl cis-trans isomerase A PpiAPeriplasmic Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350PMID: 2190212 PMID: 22030350PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY250.753SpI2424.1414-00Yn4-15c24/25oPeriplasmic1073
PROX_ECOLIP0AFM2
proX

proU

proUb2679 JW2654 periplasmic protein (SEC through IM), Glycine betaine/proline betaine-binding periplasmic ProXPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Identified DsbA substrate PMID: 19953543 PMID: 3305496 Disulfide bridge (157 163) Disulfide bond-containing protein PMID: 25664544PMID: 18498364 PMID: 19953543 PMID: 3305496 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECSURA,DSBAyesyesY220.863SpI2116.9579-00Yn5-16c21/22oPeriplasmic1052
YNFD_ECOLIP76172
ynfD
b1586 JW5259 periplasmic protein (SEC through IM), YnfDPeriplasmicExperimentally verified gene-product. PMID: 9868784PMID: 9868784PeriplasmicGSoluble IM FractionPeriplasmic (Experimental)SECnoyesY220.874SpI2122.7125-00Yn3-14c21/22oExtracellular979
YDIY_ECOLIP76206
ydiY
b1722 JW1711 periplasmic protein (SEC through IM), YdiYPeriplasmicGN/APeriplasmicSECyesyesY260.481SpI2520.5374-00Yn7-18c23/24oUnknown215
YNJH_ECOLIP76227
ynjH
b1760 JW1749 periplasmic protein (SEC through IM), YnjHPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECnoyesY190.569SpI1811.8884-00Yn4-14c18/19oCytoplasmicMembrane927
YECT_ECOLIP76296
yecT
b1877 JW5310 periplasmic protein (SEC through IM), YecTPeriplasmicGN/APeriplasmicSECnoyesY190.831SpI1811.1311-00Yn4-14c18/19oUnknown431
MEPS_ECOLIP0AFV4
mepS

spr yeiV

spr yeiVb2175 JW2163 OM lipoprotein (SEC through IM), inserted in OM by LOL), Murein DD-endopeptidase MepS/Murein LD-carboxypeptidase MepSOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY340.288SpII2611.4182Pos+2=S00Yn14-24c29/30oUnknown236
RSEB_ECOLIP0AFX9
rseB
b2571 JW2555 periplasmic protein (SEC through IM), Sigma-E factor regulatory RseB PeriplasmicResponce to stress complex RpoE-RseA-RseB. Proteolysis of transmembrane and cytoplasmic portions of RseA by DegS frees the sigma(E) transcription factor. RseB protein, a known negative regulator, inhibits proteolysis by DegS in vitro by binding tightly to the periplasmic domain of RseA. PMID: 17360428 The N-terminal domain of RseA sequesters ??E in the cytoplasmic membrane, preventing its association with core RNA polymerase. The C-terminal domain of RseA interacts with RseB, a periplasmic protein. PMID: 11777003 PMID: 11777003PMID: 9159523 PMID: 9159522 PMID: 17360428 PMID: 11777003PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY240.61SpI2310.5992-00Yn4-16c28/29oPeriplasmic915
SUBI_ECOLIP0AG78
sbp
b3917 JW3888 periplasmic protein (SEC through IM), Sulfate-binding SbpPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 9298646PMID: 18498364 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSURAyesyesY200.802SpI1915.2757-00Yn4-14c19/20oPeriplasmic1070
UGPB_ECOLIP0AG80
ugpB
b3453 JW3418 periplasmic protein (SEC through IM), sn-glycerol-3-phosphate-binding periplasmic UgpB Periplasmic Identified DsbA substrate PMID: 19953543 PMID: 3062310 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 3062310 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY240.804SpI2317.1867-00Yn7-18c23/24oPeriplasmic1064
FLHE_ECOLIP76297
flhE
b1878 JW1867 periplasmic protein (SEC through IM), FlhEPeriplasmicPart of the flagellar export apparatus Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECFlayesyesY170.511SpI168.24229-00Yn3-14c26/27oUnknown268
YECR_ECOLIP76308
yecR
b1904 JW1892 OM lipoprotein (SEC through IM, inserted in OM by LOL), YecROuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLnoyesN250.325SpII158.98675Pos+2=T00Yn3-14c22/23oUnknown215
YOEA_ECOLIP76356
yoeA
b4582 JW1980 b1995 b1998OM b-barrel protein (SEC through IM, inserted in OM by BAM), Putative YoeAOuter Membrane b-barrel proteinHN/AOuter Membrane ??-barrel proteinSECBAMpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoY290.402SpI288.15876-00Yn12-23c28/29oOuterMembrane9
PSTS_ECOLIP0AG82
pstS

phoS

phoSb3728 JW3706 periplasmic protein (SEC through IM), Phosphate-binding PstS PeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Copurifies with trigger factor in pull down assays. PMID: 9298646PMID: 18498364 PMID: 19737520 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)TFSECSURAyesyesY260.546SpI2523.9055-10Yn6-17c25/26oPeriplasmic1079
SLT_ECOLIP0AGC3
slt

sltY

sltYb4392 JW4355 periplasmic protein (SEC through IM), Soluble lytic murein transglycosylase SltPeriplasmic Disulfide bridge (133 166) Disulfide bond-containing protein PMID: 25664544PMID: 1938883 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY280.803SpI2712.0915-00Yn11-22c27/28oPeriplasmic1010
MLTF_ECOLIP0AGC5
mltF

yfhD

yfhDb2558 JW2542 periplasmic peripheral OM protein (SEC through IM), Membrane-bound lytic murein transglycosylase F MltFPeripheral outer membrane protein facing the periplasmPMID: 18234673Peripheral outer membrane protein facing the periplasmF3N/ACell outer membrane PeriplasmicSECnoyesN330.227SpI303.07095-10Yn9-20c32/33oCytoplasmic910
SODC_ECOLIP0AGD1
sodC
b1646 JW1638 periplasmic protein (SEC through IM), Superoxide dismutase SodCPeriplasmic Disulfide bridge (74 169) PMID: 9405149 Disulfide bond-containing protein PMID: 25664544PMID: 8626323 PMID: 9405149 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY200.82SpI1916.2903-00Yn4-14c19/20oPeriplasmic10
YEGJ_ECOLIP76394
yegJ
b2071 JW2056 periplasmic protein (SEC through IM), YegJPeriplasmicGN/APeriplasmicSECnoyesY190.264SpI199.75379-00Yn4-14c19/20oUnknown279
YEGR_ECOLIP76406
yegR
b2085 JW5837 OM lipoprotein (SEC through IM, inserted in OM by LOL), YegROuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLyesyesY220.281SpII1715.1742Pos+2=A00Yn4-14c22/23oUnknown254
YFAT_ECOLIP76466
yfaT
b2229 JW2223 periplasmic protein (SEC through IM), YfaTPeriplasmicGN/APeriplasmicSECnoyesY200.277SpI193.99575-00Yn4-15c19/20oCytoplasmicMembrane926
YFDX_ECOLIP76520
yfdX
b2375 JW2372 periplasmic protein (SEC through IM), YfdXPeriplasmicPMID: 11157960PeriplasmicGN/APeriplasmic (Experimental)SECyesyesY220.881SpI2120.5809-00Yn4-15c21/22oUnknown249
MLTC_ECOLIP0C066
mltC

yggZ

yggZb2963 JW5481 OM lipoprotein (SEC through IM), inserted in OM by LOL), Membrane-bound lytic murein transglycosylase C MltCOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY240.3SpII1614.8852Pos+2=S00Yn5-15c20/21oUnknown217
MEPA_ECOLIP0C0T5
mepA
b2328 JW2325 periplasmic protein (SEC through IM), Penicillin-insensitive murein endopeptidase MepAPeriplasmicSubstrate of periplasmic disulfide oxidoreductases DsbC and DsbA. Identified DsbC substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 2187143 Disulfide bridge (44 265;187 235;216 223) Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 19953543 PMID: 2187143 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECDSBA,DSBCyesyesY200.847SpI1922.606-00Yn4-14c19/20oPeriplasmic1016
DEGP_ECOLIP0C0V0
degP

htrA ptd

htrA ptdb0161 JW0157 periplasmic protein (SEC through IM), serine endoprotease DegP PeriplasmicSecB substrate. Substrate of periplasmic disulfide oxidoreductases DsbA. HtrA was not detected by the immunoblotting technique in the periplasm or in the fraction of soluble proteins but was found in the inner membrane. DegP oligomerizes as a hexameric cage but in its presence DegP reorganizes into 12 and 24-mer cages with large chambers that house the substrate for degradation or refolding. Size exclusion chromatography and electron microscopy show that the size of the substrate molecule is the main factor conditioning the oligomeric state adopted by the enzyme. Identified DsbA substrate PMID: 19953543 PMID: 2180903 Disulfide bridges between 83 and 95 PMID: 12878036 Disulfide bridge (83 95) PMID: 12878036 Disulfide bond-containing protein PMID: 25664544PMID: 16352602 PMID: 14726535 PMID: 21370981 PMID: 19525348 PMID: 9083020 PMID: 21526129 PMID: 19953543 PMID: 2180903 PMID: 12878036 PMID: 25664544PeriplasmicGN/ACell inner membrane Periplasmic (Experimental)SECBSECDSBAyesyesY270.841SpI2628.3128-00Yn4-19c26/27oPeriplasmic1031
EMTA_ECOLIP0C960
emtA

mltE sltZ ycgP

mltE sltZ ycgPb1193 JW5821 OM lipoprotein (SEC through IM), inserted in OM by LOL), Endo-type membrane-bound lytic murein transglycosylase A EmtAOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY490.204SpII1518.8581Pos+2=S00Yn5-13c18/19oCytoplasmicMembrane915
YFFQ_ECOLIP76548
yffQ
b2448 periplasmic protein (SEC through IM), YffQPeriplasmicGN/APeriplasmicSECProphage Integrase (EcoGene)nonoN190.652SpI183.21713-00Yn3-13c18/19oUnknown4
YFGI_ECOLIP76573
yfgI
b2506 JW2490 periplasmic protein (SEC through IM), YfgIPeriplasmicGN/APeriplasmicSECnoyesY200.625SpI197.20342-00Yn4-14c32/33oUnknown211
YKFB_ECOLIP77162
ykfB
b0250 JW0239 periplasmic protein (SEC through IM), YkfBPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECProphage Integrase (EcoGene)nonoY240.716SpI2317.8556-00Yn11-19c23/24oUnknown259
ACFD_ECOLIP0CK95
yghJ
b4466 JW5925 ECK2968IM lipoprotein (SEC through IM), inserted in OM by LOL), Putative AcfD homolog YghJInner Membrane LipoproteinEN/ACell membrane Inner membrane lipoproteinSECLOLnoyesY230.283SpII2337.591Pos+2=D00Yn10-21c26/27oUnknown6
RLPA_ECOLIP10100
rlpA
b0633 JW0628 OM lipoprotein (SEC through IM), inserted in OM by LOL), Endolytic PG transglycosylase RlpA RlpAOuter Membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005). Contains a SPOR domain. PMID: 15174130PMID: 15174130 PMID: 12488465 PMID: 15911532 PMID: 19880599 PMID: 20932056Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesN200.14SpII1719.3561Pos+2=T00Yn5-15c20/21oUnknown2
FADL_ECOLIP10384
fadL

ttr

ttrb2344 JW2341 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Long-chain fatty acid transport FadLOuter Membrane b-barrel proteinSubstrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 1987139PMID: 19343722 PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 11266632 PMID: 15178802 PMID: 16079137 PMID: 20932056 PMID: 19953543 PMID: 1987139Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel protein (Experimental)SECSURA,SKPBAMyesyesY260.796SpI2516.4528-00Yn10-20c25/26oOuterMembrane101
CUSF_ECOLIP77214
cusF

cusX ylcC

cusX ylcCb0573 JW0562 periplasmic protein (SEC through IM), Cation efflux system CusFPeriplasmicPMID: 12813074PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY230.444SpI228.68332-00Yn4-15c22/23oPeriplasmic10
YDDL_ECOLIP77519
yddL
b1472 JW1468 OM b-barrel protein (SEC through IM), YddLOuter Membrane b-barrel proteinHN/APeriplasmicSECpseudogene (Ochman & Davalos, 2006), pseudogene (Uniprot)yesyesY220.898SpI2118.2436-00Yn5-16c21/22oOuterMembrane948
YSAB_ECOLIQ2M7M3
ysaB
b4553 JW3532 OM lipoprotein (SEC through IM, inserted in OM by LOL), YsaBOuter Membrane LipoproteinIN/ACell membrane Outer membrane LipoproteinSECLOLyesyesY270.418SpII1715.6662Pos+2=S00Yn5-16c26/27oUnknown236
IAP_ECOLIP10423
iap
b2753 JW2723 periplasmic peripheral IM protein (SEC through IM), Alkaline phosphatase isozyme conversion IapPeripheral inner membrane protein facing the periplasmPMID: 3316184Peripheral inner membrane protein facing the periplasmF2N/AMembrane associated (Experimental)SECyesyesY250.707SpI2413.6553-00Yn9-20c24/25oUnknown425
FECA_ECOLIP13036
fecA
b4291 JW4251 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Fe(3+) dicitrate transport FecAOuter Membrane b-barrel proteinSubstrate of periplasmic peptidyl prolyl cis???trans isomerase SurA. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 PMID: 2836368PMID: 19343722 PMID: 15911532 PMID: 12624733 PMID: 11266632 PMID: 11872840 PMID: 20932056 PMID: 19953543 PMID: 2836368Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane ??-barrel protein (Experimental)SECSURA,SKPBAMnoyesY340.831SpI3318.814-00Yn19-29c33/34oOuterMembrane101
TREA_ECOLIP13482
treA

osmA

osmAb1197 JW1186 periplasmic protein (SEC through IM), trehalase TreAPeriplasmic Potential Skp substrate PMID: 19953543 PMID: 2671658 Disulfide bond-containing protein PMID: 25664544 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 2671658 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSKPyesyesY310.702SpI3017.5054-00Yn13-26c30/31oPeriplasmic1070
YICS_ECOLIQ2M7X4
yicS
b4555 JW5965 periplasmic protein (SEC through IM), YicSPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesN220.681SpI2110.9898-00Yn4-14c21/22oUnknown2
PBL_ECOLIQ46790
pbl
b2854 periplasmic protein (SEC through IM), Putative PG-binding-like protein PblPeriplasmicGN/APeriplasm CytoplasmicSECpseudogene (Uniprot)nonoY250.548SpI242.39101-00Yn8-19c24/25oPeriplasmic928
YGHG_ECOLIQ46835
yghG
b2971 JW2938 OM lipoprotein (SEC through IM, inserted in OM by LOL), YghGOuter Membrane LipoproteinBelongs to the GSP C family. Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesY290.253SpII2417.6171Pos+2=A00Yn10-22c27/28oUnknown240
YFEK_ECOLIQ47702
yfeK
b2419 JW2412 periplasmic protein (SEC through IM), YfeKPeriplasmicGN/APeriplasmicSECnoyesY200.758SpI192.85333-00Yn4-15c19/20oUnknown277
CHIA_ECOLIP13656
chiA

yheB

yheBb3338 JW3300 periplasmic & extra-cellular protein (SEC through IM), TSS secreted over OM), Probable bifunctional chitinase/lysozyme ChiAPeriplasmic, Extra-cellularCan be fully secreted when the cryptic T2S system is expressed. PMID: 10760150 Disulfide bridge (628 673) Disulfide bond-containing protein PMID: 25664544PMID: 11118204 PMID: 10760150 PMID: 25664544Periplasmic, Extra-cellularG, XN/APeriplasm Periplasmic (Experimental)SECT2SnoyesY250.672SpI2420.7505-00Yn11-20c24/25oPeriplasmic10
FECB_ECOLIP15028
fecB
b4290 JW4250 periplasmic & peripheral IM protein (SEC through IM), Fe(3+) dicitrate-binding periplasmic FecBPeripheral inner membrane protein facing the periplasm, periplasmicPMID: 2651410Peripheral inner membrane protein facing the periplasm, periplasmicF2, GN/APeriplasmPeriplasmic (Experimental)SECnoyesY220.843SpI218.42911-00Yn7-16c21/22oPeriplasmic98
PHND_ECOLIP16682
phnD

psiD

psiDb4105 JW4066 periplasmic protein (SEC through IM), Phosphonates-binding periplasmic protein PhnDPeriplasmicPMID: 16751609PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY270.567SpI2616.4228-00Yn6-21c26/27oPeriplasmic10
CYSP_ECOLIP16700
cysP
b2425 JW2418 periplasmic protein (SEC through IM), Thiosulfate-binding protein CysPPeriplasmicPMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY260.741SpI2514.3932-00Yn10-20c25/26oPeriplasmic1061
YJDP_ECOLIQ6BEX5
yjdP
b4487 JW5890 periplasmic protein (SEC through IM), YjdPPeriplasmicGN/APeriplasmicSECnoyesY230.721SpI2214.9551-00Yn6-17c22/23oUnknown2
FHUE_ECOLIP16869
fhuE
b1102 JW1088 OM b-barrel protein (SEC through IM, inserted in OM by BAM), FhuE receptor FhuEOuter Membrane b-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003)','Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) PMID: 3032906PMID: 10806384 PMID: 3032906Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane ??-barrel protein (Experimental)SECBAMnoyesY370.821SpI3620.6615-00Yn19-30c36/37oOuterMembrane100
CIRA_ECOLIP17315
cirA

cir feuA

cir feuAb2155 JW2142 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Colicin I receptor CirAOuter Membrane b-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 10430870 Disulfide bond-containing protein PMID: 25664544PMID: 15911532 PMID: 12624733 PMID: 10806384 PMID: 20932056 PMID: 19953543 PMID: 10430870 PMID: 25664544Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane ??-barrel protein (Experimental)SECDSBA,SKPBAMyesyesY260.695SpI2511.8271-00Yn10-20c25/26oOuterMembrane1046
YFAA_ECOLIP17994
yfaA

pufY

pufYb2230 JW2224 periplasmic protein (SEC through IM), YfaAPeriplasmicGSoluble IM FractionPeriplasmicSECnoyesN310.233SpI305.42187-11Ni12-31oCytoplasmicMembrane989
GGT_ECOLIP18956
ggt
b3447 JW3412 periplasmic protein (SEC through IM), Glutathione hydrolase proenzyme GgtPeriplasmic Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 1360205 PMID: 2570061 PMID: 25403562PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECYfgMyesyesY260.723SpI2520.0548-00Yn10-21c25/26oPeriplasmic1036
AGP_ECOLIP19926
agp
b1002 JW0987 periplasmic protein (SEC through IM), Glucose-1-phosphatase AgpPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 2153660 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY230.88SpI2221.9324-00Yn5-16c22/23oPeriplasmic1062
RNI_ECOLIP21338
rna

rnsA

rnsAb0611 JW0603 periplasmic protein (SEC through IM), Ribonuclease I RnaPeriplasmicSubstrate of periplasmic disulfide oxidoreductases DsbC and DsbA. Identified DsbA substrate PMID: 19953543 PMID: 2253883 Disulfide bridge (103 159) PMID: 14726535 PMID: 19953543 PMID: 2253883 PeriplasmicGN/APeriplasm Cytoplasm Periplasmic (Experimental)SECDSBA,DSBCyesyesY240.538SpI2515.6073-00Yn8-18c23/24oPeriplasmic1031
NMPC_ECOLIP21420
nmpC

phmA

phmAb0553 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Putative porin NmpC Outer Membrane b-barrel proteinPMID: 337109Outer Membrane b-barrel proteinHN/ACell outer membrane; Multi-pass membrane protein Outer Membrane ss-barrel protein(experimental)SECBAMpseudogene (Uniprot) yesnoY240.879SpI2325.1335-00Yn4-15c23/24oOuterMembrane1011
YCBB_ECOLIP22525
ycbB
b0925 JW0908 periplasmic peripheral OM protein (SEC through IM), Probable L,D-transpeptidase YcbBPeripheral outer membrane protein facing the periplasmYcbB forms direct meso- diaminopimelate (DAP-DAP, or 3-3) crosslinks within the peptidoglycan.PMID: 23832002Peripheral outer membrane protein facing the periplasmF3N/AMembrane PeriplasmicSECyesyesY310.448SpI3010.8337-00Yn11-22c30/31oPeriplasmic963
ECOT_ECOLIP23827
eco

eti

etib2209 JW2197 periplasmic protein (SEC through IM), EcoPeriplasmic Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 9298646 Disulfide bridge (70 107) Disulfide bond-containing protein PMID: 25664544PMID: 15911532 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY210.889SpI2016.5012-00Yn4-15c20/21oPeriplasmic1085
OPPA_ECOLIP23843
oppA
b1243 JW1235 periplasmic protein (SEC through IM), oligopeptide-binding protein OppAPeriplasmicSecB substrate. Potential Skp substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 Disulfide bridge (297 443) Disulfide bond-containing protein PMID: 25664544PMID: 16352602 PMID: 19953543 PMID: 9298646 PMID: 22030350 PMID: 25664544PeriplasmicGSoluble IM FractionPeriplasmPeriplasmic (Experimental)SECBSECyesyesY270.825SpI2618.3169-10Yn8-18c26/27oPeriplasmic1073
DPPA_ECOLIP23847
dppA
b3544 JW3513 periplasmic protein (SEC through IM), dipeptide transport DppAPeriplasmicSubstrate of periplasmic disulfide oxidoreductases DsbA. Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 Potential Skp substrate PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bridge (34 262;450 463) Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 15911532 PMID: 19953543 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBA,SKPyesyesY290.638SpI2816.4393-00Yn13-23c28/29oPeriplasmic1085
PSPE_ECOLIP23857
pspE
b1308 JW1301 periplasmic protein (SEC through IM), Thiosulfate sulfurtransferase PspE PeriplasmicExperimentally verified gene-product. Verified that the signal peptide is cleaved. PMID: 9868784 Disulfide bond-containing protein PMID: 25664544PMID: 9868784 PMID: 1712397 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECProphage TransposaseyesnoY200.9SpI1920.0627-00Yn5-15c19/20oUnknown2
PRC_ECOLIP23865
prc

tsp

tspb1830 JW1819 periplasmic peripheral IM protein (SEC through IM), Tail-specific protease PrcPeripheral inner membrane protein facing the periplasm Fractionation of the maxicells producing the product or prc gene suggested that the product was associated with the periplasmic side of the cytoplasmic membrane. The prc gene, which is involved in cleavage of the C-terminal peptide from the precursor form of penicillin-binding protein 3 (PBP 3) of Escherichia coli. PMID: 1856173 PMID: 1729701PMID: 1856173 PMID: 1729701Peripheral inner membrane protein facing the periplasmF2N/ACell inner membrane; Peripheral membrane protein; Periplasmic sidePeriplasmic (Experimental)SECyesyesY230.786SpI2211.2952-00Yn7-17c22/23oCytoplasmicMembrane10
NLPC_ECOLIP23898
nlpC
b1708 JW1698 OM lipoprotein (SEC through IM), inserted in OM by LOL), Probable endopeptidase NlpC Outer Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY210.325SpII1516.0698Pos+2=S00Yn3-13c17/18oUnknown234
ACRE_ECOLIP24180
acrE

envC

envCb3265 JW3233 IM lipoprotein (SEC through IM), inserted in OM by LOL), Multidrug export AcrE Inner Membrane LipoproteinProven pignal peptidase II substrate.PMID: 8472900 PMID: 15174130Inner Membrane LipoproteinEN/ACell inner membrane Inner membrane lipoproteinSECLOLyesyesY230.241SpII2310.9032Pos+2=N00Yn7-18c23/24oCytoplasmicMembrane970
DACB_ECOLIP24228
dacB
b3182 JW3149 periplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine carboxypeptidase DacBPeripheral inner membrane protein facing the periplasmExported from cytosol and signal peptide is cleaved. Anchored via C terminal the rest of the protein protudes into periplasm. Involved in peptidoglycan biosynthesis and is Penicillin-binding. PMID: 16411754 PMID: 15576782 DacB(PBP-4) anchors to the periplasmic face of the inner membrane via C-terminal amphiphilic alpha-helix. PMID: 9371419PMID: 12444970 PMID: 15911532 PMID: 16411754 PMID: 15576782 PMID: 9371419Peripheral inner membrane protein facing the periplasmF2N/APeriplasm Membrane anchored (Experimental)SECyesyesY210.58SpI2013.4163-00Yn6-16c20/21oPeriplasmic934
ASLA_ECOLIP25549
aslA

atsA

atsAb3801 JW3773 periplasmic protein (SEC through IM), Arylsulfatase AslAPeriplasmicGN/APeriplasm PeriplasmicSECnoyesY250.743SpI2417.5099-00Yn10-20c24/25oUnknown625
AMY1_ECOLIP25718
malS
b3571 JW3543 periplasmic protein (SEC through IM), alpha-amylase MalSPeriplasmic Disulfide bridge (57 75;121 537) PMID: 9268356 Disulfide bond-containing protein PMID: 25664544PMID: 1544897 PMID: 9268356 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY180.764SpI1714.5348-00Yn3-11c17/18oPeriplasmic1025
END1_ECOLIP25736
endA
b2945 JW2912 periplasmic protein (SEC through IM), Endonuclease-1 EndAPeriplasmic Identified DsbA substrate PMID: 19953543 PMID: 7867949 Disulfide bond-containing protein PMID: 25664544PMID: 4955462 PMID: 19953543 PMID: 7867949 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECDSBAnoyesY230.883SpI2222.5344-00Yn5-16c22/23oUnknown599
LOIP_ECOLIP25894
loiP

yggG

yggGb2936 JW2903 OM lipoprotein (SEC through IM), inserted in OM by LOL), Metalloprotease LoiP Outer Membrane Lipoprotein Disulfide bridge (53 108) PMID: 22491786PMID: 17909889 PMID: 22491786 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane LipoproteinSECLOLyesyesN350.146SpII1825.8287Pos+2=Q00Yn5-16c34/35oUnknown260
YDBD_ECOLIP25907
ydbD
b1407 JW5221 periplasmic protein (SEC through IM), YdbDPeriplasmicGN/APeriplasmicSECnoyesY250.744SpI247.29978-00Yn12-20c24/25oCytoplasmicMembrane928
BGLH_ECOLIP26218
bglH

yieC

yieCb3720 JW3698 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Cryptic porin BglHOuter Membrane b-barrel protein Reconstitution experiments with lipid bilayer membranes defined BglH as a channel-forming component, i.e. it is an outer membrane porin. Can be easily removed from the outer membrane by treatment with detergent. PMID: 10027967 PMID: 10027967PMID: 10027967Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel protein (Experimental)SECBAMnoyesY260.64SpI2513.3498-00Yn6-17c25/26oOuterMembrane108
AMIB_ECOLIP26365
amiB

yjeD

yjeDb4169 JW4127 periplasmic protein (SEC through IM), N-acetylmuramoyl-L-alanine amidase AmiB PeriplasmicPMID: 12787347PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY230.861SpI2213.4392-00Yn9-17c22/23oUnknown230
YIGE_ECOLIP27840
yigE
b4482 JW5591 periplasmic protein (SEC through IM), YigEPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURApseudogene (Ochman & Davalos, 2006)nonoY330.615SpI3210.2626-00Yn19-29c33/34oUnknown2
MLIC_ECOLIP28224
mliC

ydhA

ydhAb1639 JW1631 OM lipoprotein (SEC through IM), inserted in OM by LOL), Membrane-bound lysozyme inhibitor of C-type lysozyme MliCOuter Membrane Lipoprotein Disulfide bridge (37 102) PMID: 16937244PMID: 18369469 PMID: 16937244Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane LipoproteinSECLOLyesyesY230.288SpII177.61087Pos+2=S00Yn6-15c20/21oUnknown253
CSGA_ECOLIP28307
csgA
b1042 JW1025 Curli related extra-cellular peripheral OM protein (SEC through IM), secreted over OM by curli), Major curlin subunit CsgAPeripheral outer membrane protein facing the extra-cellular spaceCurli component. CsgA, is secreted from the cell in an unpolymerized form PMID: 11823641 The secretion and stability of CsgA and CsgB are dependent on the outer membrane lipoprotein CsgG. PMID: 21645131 Curli are a functional amyloid whose in vivo polymerization requires a dedicated nucleator protein, CsgB, and an assembly protein, CsgF. Without CsgF, curli subunits are released from the cell into the media and are inefficiently polymerized, resulting in fewer and mislocalized curli fibers. PMID: 19131513 PMID: 9383186 PMID: 9312041 During a process called interbacterial complementation, a csgB mutant cell secretes soluble CsgA that can be assembled on the surface of a cell expressing only csgB PMID: 8817489 High levels of both IbsC and ShoB lead to changes in membrane potential suggesting that both act at the membrane, consistent with the hydrophobic nature of the proteins.PMID: 16704339 PMID: 11823641 PMID: 21645131 PMID: 19131513 PMID: 9383186 PMID: 9312041 PMID: 8817489 PMID: 18710431Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbrium Cell surface appendage (Experimental)CurliSEC CurliyesyesY210.854SpI2020.7833-00Yn3-14c20/21oExtracellular966
METQ_ECOLIP28635
metQ

yaeC

yaeCb0197 JW0193 IM lipoprotein (SEC through IM), inserted in OM by LOL), D-methionine-binding MetQInner Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 12218041PMID: 15174130 PMID: 12218041Inner Membrane LipoproteinESoluble IM FractionCell membrane Inner membrane lipoprotein (Experimental)SECLOLyesyesN250.18SpII2219.6725Pos+2=G00Yn7-18c23/24oCytoplasmicMembrane985
GLTF_ECOLIP28721
gltF
b3214 JW3181 Fimbrial periplasmic protein (SEC through IM), GltFPeriplasmicPutative chaperone???usher fimbrial operon (class ??). Fimbrial Subunit. PMID: 10481090PMID: 20345943 PMID: 21890895 PMID: 10481090PeriplasmicGN/ACell membrane Periplasmic (Experimental)fimbriaeSECnoyesY260.754SpI2526.3964-00Yn7-18c25/26oUnknown295
YHCA_ECOLIP28722
yhcA
b3215 JW3182 Fimbrial periplasmic protein (SEC through IM), Chaperone YhcAPeriplasmicPotential fimbrial yhc operon (class ??); Usher.PMID: 20345943PeriplasmicGN/APeriplasm PeriplasmicfimbriaeSECnoyesN200.315CYT0-0.200913-00Yn5-13c21/22oCytoplasmic826
FIMD_ECOLIP30130
fimD
b4317 JW5780 Fimbrial OM b-barrel protein (SEC through IM, chaperone usher export system in OM), FimDOuter Membrane b-barrel proteinFim operon (class ??1); Usher. ??uter membrane protein related to resistance to ampicillin and tetracycline. Outer membrane protein determined by LC-MS (Gevaert et al 2002) Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Identified in the outer membrane by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 12842468 Disulfide bridge (855 877) PMID: 16372265 PMID: 20345943 PMID: 12488465 PMID: 12624733 PMID: 15911532 PMID: 12842468 PMID: 24140205Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel protein (Experimental)fimbriaeSECCUyesyesY380.415SpI371.20154-10Yn23-38c45/46oOuterMembrane10
ARTI_ECOLIP30859
artI
b0863 JW0847 periplasmic protein (SEC through IM), Putative ABC transporter arginine-binding 2 ArtIPeriplasmic Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 Identified in periplasm by biochemical fractionation followed by two-dimensional gel electrophoresis and tandem mass spectrometry. PMID: 15911532 PMID: 8801422 PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544PMID: 8801422 PMID: 15911532 PMID: 9298646 PMID: 22030350 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY200.883SpI1918.5986-00Yn4-15c19/20oPeriplasmic1076
ARTJ_ECOLIP30860
artJ
b0860 JW0844 periplasmic protein (SEC through IM), ABC transporter arginine-binding 1 ArtJPeriplasmic Identified DsbA substrate PMID: 19953543 PMID: 8801423 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350PMID: 8801422 PMID: 19953543 PMID: 8801423 PMID: 22030350PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECDSBAyesyesY200.849SpI1918.9337-00Yn4-15c19/20oPeriplasmic1073
YADC_ECOLIP31058
yadC
b0135 JW0131 Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), YadCPeripheral outer membrane protein facing the extra-cellular spacePotential fimbrial yad operon (class ??4); Potential tip-adhesin.PMID: 19820722 PMID: 20345943Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbrium PeriplasmicfimbriaeSECCUnoyesY230.677SpI2212.8917-10Yn8-17c22/23oExtracellular914
YEDD_ECOLIP31063
yedD
b1928 JW1913 OM lipoprotein (SEC through IM, inserted in OM by LOL), YedDOuter Membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002). Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Identified DsbA substrate PMID: 19953543 PMID: 15174130 Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 12488465 PMID: 15911532 PMID: 19953543 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionCell membrane Outer membrane Lipoprotein (Experimental)SECDSBALOLnoyesY200.338SpII1512.6143Pos+2=A00Yn4-12c16/17oUnknown2130
POTF_ECOLIP31133
potF
b0854 JW0838 periplasmic protein (SEC through IM), Putrescine-binding periplasmic protein PotFPeriplasmic Disulfide bridge (175 239) PMID: 9651355 Disulfide bond-containing protein PMID: 25664544PMID: 9298646 PMID: 9651355 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY270.731SpI2615.245-00Yn9-20c26/27oPeriplasmic1061
YIEL_ECOLIP31471
yieL
b3719 JW5612 periplasmic protein (SEC through IM), YieLPeriplasmicGN/APeriplasmicSECnoyesY240.659SpI2316.8534-00Yn5-16c23/24oUnknown2
THIB_ECOLIP31550
thiB

tbpA yabL

tbpA yabLb0068 JW0067 periplasmic protein (SEC through IM), Thiamine-binding periplasmic protein ThiBPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Disulfide bond-containing protein PMID: 25664544PMID: 18498364 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmicSECSURAnoyesY190.685SpI1810.962-00Yn5-13c18/19oPeriplasmic1022
LPTD_ECOLIP31554
lptD

imp ostA yabG

imp ostA yabGb0054 JW0053 OM b-barrel protein (SEC through IM, inserted in OM by BAM), LPS-assembly LptD Outer Membrane b-barrel proteinThe Protein-disulfide Isomerase DsbC Cooperates with SurA and DsbA in the Assembly of LptD. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Potential Skp substrate PMID: 19953543 Identified SurA substrates PMID: 19953543 Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bridge (31 724;173 725) PMID: 20615876 PMID: 19343722 PMID: 15911532 PMID: 12724388 PMID: 16079137 PMID: 20932056 PMID: 19953543 PMID: 9298646 PMID: 22901060Outer Membrane b-barrel proteinHSoluble IM FractionCell outer membrane Outer Membrane ??-barrel protein (Experimental)SECDSBA,DSBC,SURA,SKPBAMyesyesY250.626SpI2418.6702-00Yn7-17c24/25oOuterMembrane10
NFRA_ECOLIP31600
nfrA
b0568 JW0557 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Bacteriophage adsorption A NfrAOuter Membrane b-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003)PMID: 12624733Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane ??-barrel proteinSECBAMnoyesY280.836SpI278.97469-00Yn10-21c27/28oOuterMembrane104
YADE_ECOLIP31666
yadE
b0130 JW0126 periplasmic peripheral IM protein (SEC through IM), YadEHomolog to C-terminus of DnaA which is a peripherally accossiated proteins with a C-terminal anchor.Peripheral inner membrane protein facing the periplasmF2N/APeriplasmicSECyesyesY200.838SpI1912.5161-10Yn5-15c19/20oUnknown212
FIMC_ECOLIP31697
fimC
b4316 JW4279 Fimbrial periplasmic protein (SEC through IM), Chaperone FimCPeriplasmicFim operon (class ??1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 1363735PMID: 18498364 PMID: 20345943 PMID: 1363735 PMID: 24140205PeriplasmicGN/APeriplasmPeriplasmic (Experimental)fimbriaeSECSURAyesyesN370.473SpI3611.9808-10Yn14-23c41/42oPeriplasmic10
YDDB_ECOLIP31827
yddB
b1495 JW1490 OM b-barrel protein (SEC through IM), YddBOuter Membrane b-barrel proteinHN/APeriplasmicSECnoyesN200.536SpI194.63803-00Yn4-14c19/20oOuterMembrane93
PQQL_ECOLIP31828
pqqL

yddC

yddCb1494 JW1489 periplasmic protein (SEC through IM), Probable zinc protease PqqL PeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGSoluble IM FractionCytoplasmicSECSURAnoyesN270.318SpI265.54177-10Yn8-20c26/27oCytoplasmicMembrane937
YDEK_ECOLIP32051
ydeK

orfT

orfTb1510 JW1503 OM lipoprotein (SEC through IM, inserted in OM by LOL), YdeKOuter Membrane LipoproteinIN/ACell membrane Outer membrane LipoproteinSECLOLpseudogene (Uniprot) nonoN620.164SpII180.949979Pos+2=S00NiOuterMembrane9
YIIG_ECOLIP32151
yiiG
b3896 JW3867 IM lipoprotein (SEC through IM, inserted in OM by LOL), YiiGInner Membrane Lipoprotein Proven pignal peptidase II substrate.PMID: 15174130Inner Membrane LipoproteinEN/AInner membrane lipoproteinSECLOLnoyesN220.152SpII2126.248Pos+2=D00Yn5-17c22/23oUnknown4106
YJAH_ECOLIP32681
yjaH
b4001 JW3965 OM lipoprotein (SEC through IM, inserted in OM by LOL), YjaHOuter Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLyesyesN360.151SpII306.9142Pos+2=S00Yn20-28c46/47oUnknown225
YJBF_ECOLIP32687
yjbF
b4027 JW5711 OM lipoprotein (SEC through IM, inserted in OM by LOL), YjbFOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY210.427SpII1513.4041Pos+2=S00Yn5-13c18/19oUnknown2
YJBH_ECOLIP32689
yjbH
b4029 JW3989 IM lipoprotein (SEC through IM, inserted in OM by LOL), YjbHInner Membrane LipoproteinEN/ACell membrane Membrane LipoproteinSECLOLyesyesY210.41SpII1712.8674Pos+2=Y00Yn6-14c20/21oOuterMembrane9
NRFG_ECOLIP32712
nrfG

yjcN

yjcNb4076 JW4037 OM lipoprotein (SEC through IM), inserted in OM by LOL), Formate-dependent nitrite reductase complex subunit NrfG Outer Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLyesyesN350.209SpII216.47674Pos+2=V10Yn11-22c30/31oUnknown264
MDTP_ECOLIP32714
mdtP

yjcP

yjcPb4080 JW4041 OM lipoprotein (SEC through IM), inserted in OM by LOL), Multidrug resistance MdtPOuter Membrane LipoproteinIN/ACell outer membrane Outer membrane LipoproteinSECLOLyesyesN230.147SpII234.25545Pos+2=A00Yn9-21c29/30oOuterMembrane912
YJCS_ECOLIP32717
yjcS
b4083 JW5721 periplasmic protein (SEC through IM), Putative alkyl/aryl-sulfatase YjcS PeriplasmicPeriplasmicGN/APeriplasmicSECyesyesY300.725SpI2916.7747-00Yn12-20c29/30oUnknown427
DACD_ECOLIP33013
dacD

phsE yeeC

phsE yeeCb2010 JW5329 periplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine carboxypeptidase DacDPeripheral inner membrane protein facing the periplasmPenicillin-binding protein 5 (PBP 5); membrane-bound cell wall dd-carboxypeptidase, localized in the outer leaflet of the cytosolic membrane. PMID: 8955390PMID: 20192190 PMID: 8955390Peripheral inner membrane protein facing the periplasmF2N/ACell inner membrane Membrane anchored (Experimental)SECyesyesY220.485SpI2112.6922-00Yn5-16c21/22oCytoplasmicMembrane912
YADV_ECOLIP33128
yadV

ecpD

ecpDb0140 JW0136 Fimbrial periplasmic protein (SEC through IM), Probable chaperone YadVPeriplasmicPutative chaperone???usher fimbrial operon (class ??4); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364 PMID: 20345943PeriplasmicGN/APeriplasm PeriplasmicfimbriaeSECSURAnoyesY260.667SpI2516.6944-00Yn8-19c25/26oPeriplasmic10
HTRE_ECOLIP33129
htrE
b0139 JW0135 Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), HtrEOuter Membrane b-barrel proteinPutative chaperone???usher fimbrial operon (class ??4); Usher. Disulfide bridge (838 862) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinfimbriaeSECBAMnoyesY300.677SpI296.72527-00NiOuterMembrane108
OPGG_ECOLIP33136
mdoG

opgG

opgGb1048 JW1035 periplasmic protein (SEC through IM), Glucans biosynthesis G MdoGPeriplasmicCopurifies with trigger factor in pull down assays. Potential Skp substrate PMID: 19953543 PMID: 9298646PMID: 19737520 PMID: 19953543 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)TFSECSKPyesyesY230.708SpI2216.361-00Yn6-17c22/23oPeriplasmic1023
YEBF_ECOLIP33219
yebF
b1847 JW1836 extra-cellular protein (SEC through IM, secreted in OMV), YebFExtra-cellularOuter membrane proteins OmpF, OmpC, and OmpX are central to the YebF export mechanism. Identified DsbA substrate PMID: 19953543 PMID: 16369539 Disulfide bond-containing protein PMID: 25664544PMID: 22658749 PMID: 16369539 PMID: 19953543 PMID: 25664544Extra-cellularXN/ASecreted Secreted and released (Experimental)SECOMVnoyesY220.777SpI2120.4773-00Yn5-16c21/22oExtracellular10108
YEHA_ECOLIP33340
yehA
b2108 JW2095 Fimbrial periplasmic protein (SEC through IM), YehAPeriplasmicPutative chaperone???usher fimbrial operon yeh (class ??4); Unkown function.PMID: 16372265PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY210.622SpI207.58765-00Yn7-15c20/21oUnknown248
YEHB_ECOLIP33341
yehB
b2109 JW2096 Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), YehBOuter Membrane b-barrel proteinPutative chaperone???usher fimbrial operon yeh (class ??4); Usher. Disulfide bridge (809 825) PMID: 16372265 Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinfimbriaeSECBAMnoyesY230.679SpI2211.7505-00Yn7-18c22/23oOuterMembrane105
YEHC_ECOLIP33342
yehC
b2110 JW2097 Fimbrial periplasmic protein (SEC through IM), Probable chaperone YehCPeriplasmicPutative chaperone???usher fimbrial operon yeh (class ??4); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasm PeriplasmicfimbriaeSECSURAnoyesN340.721SpI339.53077-10Yn18-29c33/34oPeriplasmic1043
YEHD_ECOLIP33343
yehD
b2111 JW2098 Fimbrial periplasmic protein (SEC through IM), YehDPeriplasmicPutative chaperone???usher fimbrial operon yeh (class ??4); Fimbrial Subunit. Disulfide bond-containing protein PMID: 25664544PMID: 19820722 PMID: 20345943 PMID: 25664544PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY230.891SpI2224.5442-10Yn4-15c22/23oUnknown295
YEHR_ECOLIP33354
yehR
b2123 JW5351 OM lipoprotein (SEC through IM, inserted in OM by LOL), YehROuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesY220.219SpII2222.3044Pos+2=G00Yn7-18c23/24oUnknown281
YEHZ_ECOLIP33362
yehZ

osmF

osmFb2131 JW2119 periplasmic protein (SEC through IM), Glycine betaine-binding YehZ PeriplasmicPMID: 15911532PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECSURAyesyesY240.77SpI2313.9464-00Yn6-17c23/24oCytoplasmicMembrane972
BGLX_ECOLIP33363
bglX

yohA

yohAb2132 JW2120 periplasmic protein (SEC through IM), beta-glucosidase BglXPeriplasmicPMID: 8757730PeriplasmicGSoluble IM FractionPeriplasmPeriplasmic (Experimental)SECyesyesY210.824SpI206.29436-00Yn4-15c20/21oPeriplasmic1031
MDTQ_ECOLIP33369
mdtQ

yohG yohH

yohG yohHb2139 JW5838/JW5358 b2138OM lipoprotein (SEC through IM), inserted in OM by LOL), Putative multidrug resistance MdtQ Outer Membrane LipoproteinIN/ACell outer membrane CytoplasmicSECLOLpseudogene (Ochman & Davalos, 2006)noyesY240.204SpII2110.0112Pos+2=A00Yn9-20c38/39oOuterMembrane102
NIKA_ECOLIP33590
nikA
b3476 JW3441 periplasmic protein (SEC through IM), Nickel-binding periplasmic protein NikAPeriplasmicMight be is co-translationally translocated through Sec translocon. PMID: 7867647 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024PMID: 15838024 PMID: 7867647 PeriplasmicGN/APeriplasm Periplasmic (Experimental)SRP (exp)SECyesyesY230.82SpI2220.282-00Yn8-18c22/23oPeriplasmic10
YDBA_ECOLIP33666
ydbA
b4492 JW5802/JW1402 b1401/b1405OM b-barrel protein (SEC through IM), T5S secreted through OM), Putative exported YdbA Outer Membrane b-barrel proteinAg43 homologue; known autotransporter protein. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a>PMID: 15590781Outer Membrane b-barrel proteinHIM (predicted)Secreted CytoplasmicSECAutotransporter(T5S)pseudogene (Uniprot)noyesY220.75SpI2002100Yn5-16c21/22oUnknown628
YEJA_ECOLIP33913
yejA
b2177 JW2165 periplasmic protein (SEC through IM), YejAPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGSoluble IM FractionPeriplasmicSECSURAnoyesY200.634SpI199.78276-10Yn5-15c19/20oPeriplasmic1019
YEJO_ECOLIP33924
yejO
b2190 JW5839 OM b-barrel protein (SEC through IM), T5S secreted through OM), Putative YejOOuter Membrane b-barrel proteinAg43 homologue; predicted autotransporter. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a>PMID: 15590781Outer Membrane b-barrel proteinHN/ACell outer membrane cytoplasmicSECAutotransporter(T5S)Insertion Sequence, Insertion Element, pseudogene (Uniprot)nonoY300.756SpI297.15031-00Yn12-22c29/30oUnknown729
HOFQ_ECOLIP34749
hofQ

hopQ

hopQb3391 JW3354 OM b-barrel protein (SEC through IM, inserted in OM by BAM), DNA utilization HofQOuter Membrane b-barrel proteinSecretin family, homologous to the secretin of T2S (P45758 (GSPD_ECOLI)); homologus to ComE of H.influenza involved in DNA uptake PMID: 16707682Outer Membrane b-barrel proteinHN/ACell outer membrane PeriplasmicSECBAMyesyesY190.736SpI1910.1451-00Yn5-13c18/19oOuterMembrane1063
YACH_ECOLIP36682
yacH
b0117 JW0113 periplasmic protein (SEC through IM), YacHPeriplasmicGN/APeriplasmicSECyesyesY230.224SpI299.50022-00Yn11-21c26/27oExtracellular913
PAGP_ECOLIP37001
pagP

crcA ybeG

crcA ybeGb0622 JW0617 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Lipid A palmitoyltransferase PagP Outer Membrane b-barrel proteinPMID: 12357033 PMID: 11266632 PMID: 11013210Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel protein (Experimental)SECBAMnoyesN260.361CYT0-0.200913-00Yn7-18c25/26oOuterMembrane109
YADK_ECOLIP37016
yadK
b0136 JW0132 Fimbrial periplasmic protein (SEC through IM), YadKPeriplasmicPutative chaperone???usher fimbrial operon (class ??4); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECyesyesY290.766SpI2816.7043-10Yn12-23c28/29oUnknown241
YADL_ECOLIP37017
yadL
b0137 JW0133 Fimbrial periplasmic protein (SEC through IM), YadLPeriplasmicPutative chaperone???usher fimbrial operon (class ??4); Unkown function.PMID: 20345943PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECnoyesY290.815SpI2819.3349-10Yn11-22c28/29oUnknown223
YADM_ECOLIP37018
yadM
b0138 JW0134 Fimbrial periplasmic protein (SEC through IM), YadMPeriplasmicPutative chaperone???usher fimbrial operon (class ??4); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECnoyesY240.878SpI2314.8521-00Yn9-17c23/24oUnknown225
BTUF_ECOLIP37028
btuF

yadT

yadTb0158 JW0154 periplasmic protein (SEC through IM), Vitamin B12-binding protein BtuFPeriplasmic Disulfide bridge (183 259) Disulfide bond-containing protein PMID: 25664544PMID: 11790740 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY230.751SpI2210.8439-00Yn8-18c22/23oPeriplasmic10
YAEI_ECOLIP37049
yaeI
b0164 JW5014 periplasmic protein (SEC through IM), Phosphodiesterase YaeI PeriplasmicGN/AMembrane anchoredSECnoyesN470.129CYT0-0.200913-00Yn7-17c22/23oUnknown26
YADN_ECOLIP37050
yadN
b0141 JW0137 Fimbrial periplasmic protein (SEC through IM), YadNPeriplasmicPutative chaperone???usher fimbrial operon (class ??4); Fimbrial Subunit. Disulfide bridge (41 86) PMID: 20345943 PMID: 19820722 PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECCUnoyesY240.713SpI2317.9817-00Yn5-15c23/24oExtracellular977
YAEF_ECOLIP37056
yaeF

yaeK

yaeKb0193 JW5016 OM lipoprotein (SEC through IM), inserted in OM by LOL), Probable peptidase YaeF Outer Membrane LipoproteinIN/ACell inner membrane Outer membrane LipoproteinSECLOLnoyesY260.176SpII209.80359Pos+2=T00Yn10-21c26/27oUnknown250
SLP_ECOLIP37194
slp
b3506 JW3474 OM lipoprotein (SEC through IM, inserted in OM by LOL), SlpOuter Membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 10806384 PMID: 9298646PMID: 15174130 PMID: 15911532 PMID: 10806384 PMID: 16079137 PMID: 20932056 PMID: 21541338 PMID: 9298646Outer Membrane LipoproteinISoluble IM FractionCell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY180.153SpII1821.4364Pos+2=S00Yn6-16c21/22oOuterMembrane10
YHJA_ECOLIP37197
yhjA
b3518 JW3486 IM lipoprotein (SEC through IM), inserted in OM by LOL), Probable cytochrome c peroxidase YhjAInner Membrane LipoproteinBy virtue of its homology to the Neisseria protein (Q5F5Z9_neigo1)PMID: 12720546Inner Membrane LipoproteinEN/AMembrane anchoredSECLOLnoyesN290.287SpI284.74738-11Ni7-28oPeriplasmic921
MODA_ECOLIP37329
modA
b0763 JW0746 periplasmic protein (SEC through IM), Molybdate-binding ModA PeriplasmicPMID: 8576221PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECnoyesY250.754SpI2418.4352-00Yn8-19c24/25oPeriplasmic1099
XYLF_ECOLIP37387
xylF

xylT

xylTb3566 JW3538 periplasmic protein (SEC through IM), D-xylose-binding periplasmic protein XylFPeriplasmicPMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY240.78SpI2314.4657-00Yn6-17c23/24oPeriplasmic10
MDTE_ECOLIP37636
mdtE

yhiU

yhiUb3513 JW3481 OM lipoprotein (SEC through IM), inserted in OM by LOL), Multidrug resistance MdtEOuter Membrane LipoproteinOuter membrane protein related to resistance to ampicillin and tetracycline Proven pignal peptidase II substrate.PMID: 16372265 PMID: 15174130Outer Membrane LipoproteinISoluble IM FractionCell inner membrane Inner membrane lipoproteinSECLOLyesyesY260.181SpII2022.544Pos+2=D00Yn7-15c20/21oCytoplasmicMembrane989
YHJJ_ECOLIP37648
yhjJ
b3527 JW3495 periplasmic protein (SEC through IM), YhjJPeriplasmic Potential Skp substrate PMID: 19953543 PMID: 9298646 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECSKPyesyesY250.722SpI2414.0569-00Yn8-19c24/25oUnknown283
BCSC_ECOLIP37650
bcsC

yhjL

yhjLb3530 JW5942 periplasmic protein (SEC through IM), Cellulose synthase operon C BcsCPeriplasmicGN/APeriplasmicSECnoyesY240.51SpI236.58448-00Yn8-18c23/24oUnknown4
GUN_ECOLIP37651
bcsZ

bcsC yhjM

bcsC yhjMb3531 JW3499 periplasmic protein (SEC through IM), Endoglucanase BcsZPeriplasmicPMID: 10102357 PMID: 11260463 PMID: 21454578 PMID: 24097954PeriplasmicGN/ASecretedPeriplasmic (Experimental)SECnoyesY220.88SpII2212.5942Pos+2=T00Yn6-17c21/22oExtracellular106
YHJY_ECOLIP37663
yhjY
b3548 JW5659 OM b-barrel protein (SEC through IM, T5S secreted through OM), YhjYOuter Membrane b-barrel proteinAg43 homologue ; predicted autotransporter. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a>PMID: 15590781Outer Membrane b-barrel proteinHN/APeriplasmicSECAutotransporter(T5S)noyesN310.371SpI3011.8549-10Yn14-25c30/31oUnknown79
YIAO_ECOLIP37676
yiaO
b3579 JW3551 periplasmic protein (SEC through IM), 2,3-diketo-L-gulonate-binding periplasmic YiaOPeriplasmicPMID: 16385129PeriplasmicGN/APeriplasm PeriplasmicSECnoyesY250.815SpI2415.7433-00Yn6-17c24/25oPeriplasmic1020
YIAT_ECOLIP37681
yiaT
b3584 JW3556 OM b-barrel protein (SEC through IM), Putative YiaTOuter Membrane b-barrel proteinPMID: 20639525Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinSECnoyesY220.602SpI2111.315-00Yn7-17c21/22oOuterMembrane1022
ENVC_ECOLIP37690
envC

yibP

yibPb3613 JW5646 periplasmic protein (SEC through IM), Murein hydrolase activator EnvC PeriplasmicPMID: 12113939 PMID: 15165230 PMID: 19525345 PMID: 8472900PeriplasmicGSoluble IM FractionPeriplasm Inner Membrane Lipoprotein (Experimental)SECyesyesY350.862SpI3413.522-10Yn18-29c34/35oOuterMembrane910
YIBQ_ECOLIP37691
yibQ
b3614 JW5645 periplasmic protein (SEC through IM), YibQPeriplasmicPMID: 19953543PeriplasmicGN/APeriplasmicSECyesyesY240.782SpI2313.9145-10Yn8-18c23/24oUnknown214
GLTI_ECOLIP37902
gltI

ybeJ yzzK

ybeJ yzzKb0655 JW5092 periplasmic protein (SEC through IM), Glutamate/aspartate import solute-binding protein GltIPeriplasmicSubstrate of periplasmic disulfide oxidoreductases DsbA. Identified DsbA substrate PMID: 19953543 PMID: 8740179 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544PMID: 14726535 PMID: 19953543 PMID: 8740179 PMID: 22030350 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECDSBAyesyesY230.775SpI2221.5903-00Yn7-17c22/23oPeriplasmic1093
YBGD_ECOLIP37909
ybgD
b0719 JW0709 Fimbrial periplasmic protein (SEC through IM), YbgDPeriplasmicPutative chaperone???usher fimbrial operon yeh (class ??); Fimbrial Subunit. Disulfide bridge (42 81) PMID: 20345943 PMID: 19820722 PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECCUnoyesY240.878SpI2315.4399-00Yn7-18c23/24oExtracellular9
SFMF_ECOLIP38052
sfmF

ybcG

ybcGb0534 JW5072 Fimbrial periplasmic protein (SEC through IM), SfmFPeriplasmicPotential fimbrial sfm operon (class ??1); Fimbrial Subunit. Disulfide bridge (40 80) PMID: 20345943 PMID: 19820722 PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECCUnoyesY210.763SpI2016.3129-00Yn4-15c20/21oExtracellular964
TORT_ECOLIP38683
torT

yccH

yccHb0994 JW0979 periplasmic protein (SEC through IM), Periplasmic TorTPeriplasmicMight be is co-translationally translocated through Sec translocon. PMID: 8576063 The precursor of TorT harbouring hydrophobic signal sequence require SRP and FtsY in addition to SecA for maximal translocation. PMID: 24717922 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024 Disulfide bond-containing protein PMID: 25664544PMID: 15838024 PMID: 8576063 PMID: 24717922 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SRP (exp)SECyesyesY190.789SpI1812.9296-00Yn3-14c18/19oPeriplasmic1012
DEGQ_ECOLIP39099
degQ

hhoA

hhoAb3234 JW3203 periplasmic protein (SEC through IM), pH-dependent serine endoprotease DegQ PeriplasmicPMID: 8576051 PMID: 8576052 PMID: 9740056PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY280.555SpI2717.6659-10Yn7-19c27/28oPeriplasmic1066
YCHO_ECOLIP39165
ychO

ychP

ychPb1220 JW1211 periplasmic protein (SEC through IM), YchOHomologous to intimin / invasin family (yeej_coli).PeriplasmicGN/APeriplasm CytoplasmicSECyesyesY250.55SpI248.3661-00Yn8-19c24/25oOuterMembrane107
ZNUA_ECOLIP39172
znuA

yebL yzzP

yebL yzzPb1857 JW5831 periplasmic protein (SEC through IM), High-affinity zinc uptake system ZnuA Periplasmic Disulfide bond-containing protein PMID: 25664544PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY270.573SpI2318.3411-00Yn6-17c26/27oPeriplasmic1084
ERFK_ECOLIP39176
erfK

yeeG yzzT

yeeG yzzTb1990 JW1968 periplasmic peripheral OM protein (SEC through IM), Probable L,D-transpeptidase ErfKPeripheral outer membrane protein facing the periplasmPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. ErfK has been shown to crosslink Braun's lipoprotein (Lpp) to the peptidoglycan. PMID: 9298646PMID: 18498364 PMID: 23832002 PMID: 9298646Peripheral outer membrane protein facing the periplasmF3N/APeriplasm Periplasmic (Experimental)SECSURAyesyesY220.658SpI2117.0042-00Yn6-16c21/22oUnknown211
AG43_ECOLIP39180
flu

yeeQ yzzX

yeeQ yzzXb2000 JW1982 OM b-barrel protein (SEC through IM), T5S and TAM secreted in OM), Antigen 43 FluOuter Membrane b-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (PMID: 15911532, PMID: 12624733, PMID: 10806384). Potential substrate of TAM secretion systemPMID: 22466966. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a> PMID: 9298646PMID: 15590781 PMID: 12624733 PMID: 22466966 PMID: 22905239 PMID: 10806384 PMID: 15911532 PMID: 9298646Outer Membrane b-barrel proteinHN/AAntigen 43: Periplasm Outer Membrane ??-barrel protein (Experimental)SECAutotransporter(T5S), TAMProphage Integrase (EcoGene)nonoN530.646SpI525.41594-10Yn34-45c52/53oOuterMembrane1032
FIMI_ECOLIP39264
fimI
b4315 JW5779 Fimbrial periplasmic protein (SEC through IM), Fimbrin-like FimIPeriplasmicFim operon (class ??1); Fimbrial Subunit. Required for the regulation of length and mediation of adhesion of Escherichia coli type 1 fimbriae. Disulfide bridge (43 83) PMID: 19820722 PMID: 2890081 PMID: 20345943 PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECCUnoyesY200.716SpI1916.0857-00Yn6-13c19/20oExtracellular937
ALSB_ECOLIP39265
alsB

yjcX

yjcXb4088 JW4049 periplasmic protein (SEC through IM), D-allose-binding periplasmic AlsBPeriplasmicPMID: 14499611PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECnoyesY240.81SpI2318.079-10Yn8-18c23/24oPeriplasmic1053
BSMA_ECOLIP39297
bsmA

yjfO

yjfOb4189 JW5743 OM lipoprotein (SEC through IM, inserted in OM by LOL), BsmAOuter Membrane LipoproteinPMID: 20932056Outer Membrane LipoproteinIN/ACell membrane Outer membrane LipoproteinSECLOLyesyesY300.447SpII2420.0908Pos+2=S10Yn13-22c27/28oUnknown246
YTFQ_ECOLIP39325
ytfQ
b4227 JW4186 periplasmic protein (SEC through IM), ABC transporter periplasmic-binding YtfQPeriplasmic Identified DsbA substrate PMID: 19953543 PMID: 9298646 Disulfide bond-containing protein PMID: 25664544PMID: 19953543 PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECDSBAyesyesY220.849SpI2121.6548-10Yn5-13c21/22oPeriplasmic1090
NANM_ECOLIP39371
nanM

yjhT

yjhTb4310 JW5777 periplasmic protein (SEC through IM), N-acetylneuraminate epimerase NanMPeriplasmicPMID: 18063573PeriplasmicGN/APeriplasm PeriplasmicSECnoyesY200.747SpI1918.4486-00Yn4-15c19/20oUnknown275
YGIL_ECOLIP39834
ygiL
b3043 JW3011 Fimbrial periplasmic protein (SEC through IM), YgiLPeriplasmicPutative chaperone???usher fimbrial operon (class ??); Unknown function. Disulfide bridge (41 80) PMID: 19820722 PMID: 20345943 PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECCUnoyesY240.867SpI2315.5994-00Yn7-18c23/24oExtracellular992
NLPE_ECOLIP40710
nlpE

cutF

cutFb0192 JW0188 OM lipoprotein (SEC through IM, inserted in OM by LOL), NlpEOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 7635807PMID: 15174130 PMID: 20932056 PMID: 7635807Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein(experimental)SECLOLyesyesY360.226SpII2012.8918Pos+2=N00Yn6-17c35/36oOuterMembrane10112
YCBF_ECOLIP40876
ycbF
b0944 JW5124 Fimbrial periplasmic protein (SEC through IM), Chaperone YcbFPeriplasmicPotential fimbrial ycb operon (class ??1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasm PeriplasmicfimbriaeSECSURAnoyesN270.646SpI269.39817-10Yn8-19c26/27oPeriplasmic919
MLTB_ECOLIP41052
mltB
b2701 JW2671 OM lipoprotein (SEC through IM), inserted in OM by LOL), Membrane-bound lytic murein transglycosylase B MltBOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinISoluble IM FractionCell outer membrane; Lipid-anchor; Periplasmic sideOuter membrane Lipoprotein (Experimental)SECLOLyesyesY240.231SpII1824.349Pos+2=S00Yn7-17c21/22oCytoplasmicMembrane927
YGJJ_ECOLIP42591
ygjJ
b3079 JW3050 periplasmic protein (SEC through IM), YgjJPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAyesyesY220.252SpI247.25386-00Yn3-14c19/20oUnknown231
YGJK_ECOLIP42592
ygjK
b3080 JW3051 periplasmic protein (SEC through IM), Glucosidase YgjKPeriplasmicGN/APeriplasmicSECnoyesY230.898SpI2221.1996-00Yn5-16c25/26oPeriplasmic922
YRAH_ECOLIP42913
yraH
b3142 JW3111 Fimbrial periplasmic protein (SEC through IM), YraHPeriplasmicPotential fimbrial yra operon (class ??1); Fimbrial Subunit. Disulfide bridge (38 78) PMID: 19820722 PMID: 20345943 PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECCUnoyesY230.673SpI2211.7644-00Yn7-17c22/23oExtracellular9
YRAI_ECOLIP42914
yraI
b3143 JW3112 Fimbrial periplasmic protein (SEC through IM), Probable chaperone YraIPeriplasmicPotential fimbrial yra operon (class ??1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Might be is co-translationally translocated through Sec translocon. Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024PMID: 18498364 PMID: 20345943 PMID: 15838024PeriplasmicGN/APeriplasm PeriplasmicfimbriaeSRP (exp)SECSURAnoyesY240.709SpI2314.1781-10Yn7-18c23/24oPeriplasmic1056
YRAJ_ECOLIP42915
yraJ
b3144 JW3113 Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), YraJOuter Membrane b-barrel proteinPotential fimbrial yra operon (class ??1); Usher. Disulfide bridge (815 837) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinfimbriaeSECBAMnoyesN410.51SpI409.33083-00NiOuterMembrane106
YRAK_ECOLIP43319
yraK
b3145 JW3114 Fimbrial periplasmic protein (SEC through IM), YraKPeriplasmicPotential fimbrial yra operon (class ??1); Potential tip-adhesin. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 19820722 PMID: 20345943 PMID: 18498364PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECSURACUnoyesY210.726SpI2018.7753-00Yn4-15c20/21oUnknown278
YCAL_ECOLIP43674
ycaL
b0909 JW0892 OM lipoprotein (SEC through IM), inserted in OM by LOL), Metalloprotease YcaL Outer Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLyesyesN260.214SpII1926.2238Pos+2=Q00Yn6-17c25/26oUnknown224
YHCD_ECOLIP45420
yhcD
b3216 JW3183 Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), YhcDOuter Membrane b-barrel proteinPotential fimbrial yhc operon (class ??); Uknown function. Disulfide bridge (769 792) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinfimbriaeSECBAMnoyesY220.809SpI2110.0887-00Yn5-16c21/22oOuterMembrane10
LPOA_ECOLIP45464
lpoA

yraM

yraMb3147 JW3116 OM lipoprotein (SEC through IM), inserted in OM by LOL), Penicillin-binding activator LpoA Outer Membrane LipoproteinThe two OM lipoproteins, LpoA and LpoB, are essential for the function, respectively, of PBP1A and PBP1B, the major E. coli bifunctional peptidoglycans (PG) synthases. Each Lpo protein binds specifically to its cognate PBP and stimulates its transpeptidase. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Disulfide bond-containing protein PMID: 25664544PMID: 15911532 PMID: 21183073 PMID: 21183074 PMID: 20932056 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionCell outer membrane Membrane LipoproteinSECLOLnoyesY260.162SpII2612.6937Pos+2=G00Yn14-27c45/46oCytoplasmicMembrane9105
YFAL_ECOLIP45508
yfaL

yfaF yfaJ yfaK

yfaF yfaJ yfaKb2233 JW2227 OM b-barrel protein (SEC through IM), T5S secreted through OM), Probable autotransporter YfaL Outer Membrane b-barrel proteinAg43 homologue; predicted autotransporter. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a>PMID: 15590781Outer Membrane b-barrel proteinHN/AProbable autotransporter YfaL: Periplasm; Probable secreted autotransporter protein YfaL: Secreted Cell surface; Probable autotransporter YfaL translocator: Cell outer membrane PeriplasmicSECAutotransporter(T5S)yesyesY290.358SpI2813.6585-00Yn11-22c29/30oOuterMembrane952
FKBA_ECOLIP45523
fkpA

yzzS

yzzSb3347 JW3309 periplasmic protein (SEC through IM), FKBP-type peptidyl-prolyl cis-trans isomerase FkpA PeriplasmicSecB substrate. PMID: 9298646 Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasm and up-regulated in the cytoplasm of SRP-depleted cells. PMID: 22030350PMID: 16352602 PMID: 9298646 PMID: 22030350PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECBSECyesyesY260.701SpI2514.7593-00Yn7-18c25/26oPeriplasmic10
YFEN_ECOLIP45564
yfeN
b2408 JW2399 OM b-barrel protein (SEC through IM, inserted in OM by BAM), YfeNOuter Membrane b-barrel proteinHN/AOuter Membrane ??-barrel proteinSECBAMnoyesY230.452SpI2212.5667-00Yn5-16c22/23oUnknown26
AIS_ECOLIP45565
ais

pmrG

pmrGb2252 JW2246 periplasmic protein (SEC through IM), polysaccharide core heptose AisPeriplasmicPeriplasmic protein by virtue of its homology with the well characterized Salmonella homologue PmrGPMID: 16803591. Disulfide bond-containing protein PMID: 25664544PMID: 16803591 PMID: 25664544PeriplasmicGN/APeriplasm Membrane anchoredSECyesyesN320.351SpI319.81523-10Yn16-27c31/32oUnknown250
GSPD_ECOLIP45758
gspD

yheF

yheFb3325 JW5707 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Putative type II secretion system D GspDOuter Membrane b-barrel proteinPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Homolog to type two secretion system proteins PulD. Potential outer membrane b-barel protein since it is homolog to pulD major component of type two secretion system. GspD is the outer membrane secretin of type II secretion system (T2SS) which forms a multimeric pore for translocation of secreted proteins. GspD and the inner membrane protein GspC interact with each other via periplasmic domains (observed in the crystal structure). PMID: 21931548 PMID: 11266368PMID: 18498364 PMID: 14966662 PMID: 11118204 PMID: 21931548 PMID: 11266368Outer Membrane b-barrel proteinHN/ACell outer membrane Periplasmic (Experimental)SECSURABAMnoyesY240.553SpI2314.273-00Yn7-16c23/24oOuterMembrane1034
GSPJ_ECOLIP45761
gspJ

yheI

yheIb3331 JW3293 periplasmic protein (SEC through IM), Putative type II secretion system J GspJPeriplasmicPotential component of type II secretion system. GspJ is one of four low abundance pseudopillins together with GspI, H and K. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368PMID: 14966662 PMID: 11118204 PMID: 18241884 PMID: 23006128 PMID: 21890895 PMID: 11266368PeriplasmicGN/APeriplasmic (Experimental)SECT2SnoyesN280.304SpI342.3055-11Ni7-31oCytoplasmicMembrane9
GSPK_ECOLIP45762
gspK

yheJ

yheJb3332 JW3294 periplasmic protein (SEC through IM), Putative type II secretion system K GspKPeriplasmicPotential component of type II secretion system. GspK is one of four low abundance pseudopillins together with GspI, J and H. These assemble together with the major pseudopillin GspG and may be involved in initiation, stabilization, regulation or capping PMID: 11266368PMID: 14966662 PMID: 11118204 PMID: 18241884 PMID: 23006128 PMID: 21890895 PMID: 11266368PeriplasmicGN/ACell inner membrane Periplasmic (Experimental)SECT2SnoyesN250.537SpI248.69449-10Yn8-19c24/25oCytoplasmicMembrane930
YHDW_ECOLIP45766
yhdW
b3268 JW3236 periplasmic protein (SEC through IM), Putative amino-acid ABC transporter-binding YhdW Periplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGSoluble IM FractionPeriplasm CytoplasmicSECpseudogene (Uniprot) nonoY250.628SpI2420.0416-00Yn6-17c24/25oPeriplasmic1089
CPOB_ECOLIP45955
cpoB

ybgF

ybgFb0742 JW0732 periplasmic protein (SEC through IM), Cell division coordinator CpoBPeriplasmicSecB substrate. The N-terminal coiled coil of YbgFvforms a stable trimer and controls the oligomeric status of YbgF.The stable YbgF trimer undergoes a marked change in oligomeric state on binding TolA, forming a one-to-one complex with the Tol protein. PMID: 11703658PMID: 16352602 PMID: 20816983 PMID: 11703658PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECBSECyesyesY270.495SpI2613.974-00Yn9-20c26/27oPeriplasmic919
YBHC_ECOLIP46130
ybhC
b0772 JW0755 OM lipoprotein (SEC through IM), inserted in OM by LOL), Putative acyl-CoA thioester hydrolase YbhC Outer Membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Molloy et al 2000) PMID: 10806384 Disulfide bridge (185 197) PMID: 19452549PMID: 15174130 PMID: 15911532 PMID: 10806384 PMID: 20932056 PMID: 19452549Outer Membrane LipoproteinISoluble IM FractionCell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY240.274SpII2124.9976Pos+2=S00Yn9-19c24/25oOuterMembrane971
YHDP_ECOLIP46474
yhdP

yhdQ yhdR

yhdQ yhdRb4472 JW5542 OM b-barrel protein (SEC through IM, inserted in OM by BAM), YhdPOuter Membrane b-barrel proteinHN/ACytoplasmicSECBAMpseudogene (Ochman & Davalos, 2006)yesyesN300.25SpI295.14802-10Yn7-22c29/30oCytoplasmicMembrane9
AMO_ECOLIP46883
tynA

maoA

maoAb1386 JW1381 periplasmic protein (SEC through IM), Primary amine oxidase TynAPeriplasmic Potential Skp substrate PMID: 19953543 PMID: 8631685PMID: 19953543 PMID: 8631685PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECSKPnoyesY310.714SpI3012.7601-00Yn13-24c30/31oPeriplasmic1097
CSGC_ECOLIP52107
csgC
b1043 JW1026 periplasmic protein (SEC through IM), Curli assembly CsgCPeriplasmicUniprot mentions an 8aa signal peptide but Signal P prediction is for a "typical" 22 residue peptide Disulfide bond-containing protein PMID: 25664544 Disulfide bond-containing protein PMID: 25664544PMID: 21645131 PMID: 19131513 PMID: 25664544PeriplasmicGN/APeriplasm PeriplasmicSECnoyesN220.179SpI222.07115-00Yn4-16c21/22oUnknown268
YPJA_ECOLIP52143
ypjA
b2647 JW5422 OM b-barrel protein (SEC through IM, T5S secreted through OM), YpjAOuter Membrane b-barrel proteinAg43 homologue; predicted autotransporter. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a>. Potential Srp-dependent autotransporter. Homologous to hemoglobin-binding protease hbp. Hbp is the only known autotransporter that is secreted through the integral membrane in a Srp-dependent manner.PMID: 15590781 PMID: 22905239 PMID: 12466262Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinSRPSECAutotransporter(T5S)noyesY300.688SpI2911.7048-10Yn13-24c29/30oUnknown5
EMRK_ECOLIP52599
emrK
b2368 JW2365 periplasmic protein (SEC through IM), Probable multidrug resistance EmrK PeriplasmicPMID: 11914367PeriplasmicGN/ACell inner membrane Periplasmic (Experimental)SECyesyesN340.579SpI3315.7518-10Yn17-28c33/34oCytoplasmicMembrane938
HSLJ_ECOLIP52644
hslJ

ydbI

ydbIb1379 JW1374 OM lipoprotein (SEC through IM, inserted in OM by LOL), HslJOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLyesyesY250.238SpII1616.4623Pos+2=V00Yn4-15c20/21oUnknown2106
RZOD_ECOLIP58041
rzoD
b4510 JW5080 OM lipoprotein (SEC through IM), inserted in OM by LOL), Prophage RzoD (o-spanin) Outer Membrane Lipoprotein Disulfide bridge (29 29) Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane LipoproteinSECLOLProphage Integrase (EcoGene)nonoY200.187SpII1919.9508Pos+2=T00Yn8-18c22/23oUnknown2147
RZOR_ECOLIP58042
rzoR
b4528 JW5213 OM lipoprotein (SEC through IM), inserted in OM by LOL), Prophage RzoR (o-spanin) Outer Membrane Lipoprotein Disulfide bridge (29 29) Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane LipoproteinSECLOLProphage Integrase (EcoGene)nonoY200.189SpII1920.8844Pos+2=T00Yn8-18c22/23oUnknown288
LOLA_ECOLIP61316
lolA

lplA yzzV

lplA yzzVb0891 JW0874 periplasmic protein (SEC through IM), Outer-carrier LolAPeriplasmicPMID: 15276320 PMID: 7628437 PMID: 9298646PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY220.602SpI2120.5659-00Yn4-15c21/22oPeriplasmic1070
LOLB_ECOLIP61320
lolB

hemM ychC

hemM ychCb1209 JW1200 OM lipoprotein (SEC through IM), inserted in OM by LOL), Outer-LolB Outer Membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002) Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 16091355PMID: 15276320 PMID: 15174130 PMID: 12488465 PMID: 15911532 PMID: 12624733 PMID: 20932056 PMID: 21541338 PMID: 16091355Outer Membrane LipoproteinISoluble IM FractionCell outer membrane; Lipid-anchorOuter membrane Lipoprotein (Experimental)SECLOLyesyesY240.169SpII2113.4863Pos+2=S00Yn11-22c27/28oPeriplasmic985
SECM_ECOLIP62395
secM

srrA yacA

srrA yacAb0097 JW5007 cytoplasmic & periplasmic protein (SEC through IM), Secretion monitor SecMCytoplasmic, PeriplasmicSecM regulates secA expression by translational coupling of the secM secA operon. Fusion of SecM with alkaline phosphatase activity exhibits substantial activity in the periplasm. SecM periplasmic form is rapidly degraded. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 11597451PMID: 18498364 PMID: 1834634 PMID: 11597451Cytoplasmic, PeriplasmicA, GN/ACytoplasm; cytosol Periplasmic (Experimental)SECSURAyesyesY380.527SpI3711.5151-10Yn20-31c37/38oCytoplasmic10
YDDW_ECOLIP64426
yddW
b1491 JW1486 OM lipoprotein (SEC through IM), inserted in OM by LOL), UPF0748 YddWOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY360.168SpII2712.5186Pos+2=K00Yn16-26c30/31oUnknown262
YDCL_ECOLIP64451
ydcL
b1431 JW1427 OM lipoprotein (SEC through IM, inserted in OM by LOL), YdcLOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesY250.223SpII2019.8371Pos+2=A00Yn9-18c23/24oUnknown2
YRAP_ECOLIP64596
yraP
b3150 JW3119 OM lipoprotein (SEC through IM, inserted in OM by LOL), YraPOuter Membrane LipoproteinContains 2 BON domains <a target="_blank" href="http://www.ebi.ac.uk/interpro/entry/IPR007055">IPR007055</a>. BON domains are putative membrane-binding domains PMID: 12878000.The BON domain is typically ~60 residues long and has an alpha/beta predicted fold. The domain architecture of two BON domains alone suggests that these domains contact the surfaces of phospholipids, with each domain contacting a membrane. These are found in a family of osmotic shock protection proteins (e.g. P27291). It is also found in some Secretins and a group of potential haemolysins. Its likely function is attachment to phospholipid membranes. Is homologous to the OsmY_Ecoli protein. There is a conserved glycine residue and several hydrophobic regions. This pattern of conservation is more suggestive of a binding or structural function rather than a catalytic function. Most proteobacteria seem to possess one or two BON-containing proteins, typically of the OsmY-type proteins. Outside of this group the distribution is more disparate. OsmY protein is a 20 kDa outer membrane or periplasmic protein that is expressed in response to a variety of stress conditions. In particular, helping to provide protection against osmotic shock. One hypothesis is that OsmYPrevents shrinkage of the cytoplasmic compartment by contacting the phospholipid interfaces surrounding the periplasmic space. Proven pignal peptidase II substrate PMID: 15174130. Detected in the outer membrane fraction, with mass spectrometric analysis coupled by SDS gel electrophoresisPMID: 20932056. Outer membrane protein determined by LC-MS PMID: 12488465. DacB, DcrB, HybA, and YraP were assigned to either the inner or outer membrane. These apparent differences could be reasonably accommodated if these proteins were peripherally associated with the side of either the inner or outer membrane that faces the periplasmic space PMID: 15911532. PMID: 15174130PMID: 12878000 PMID: 15174130 PMID: 12488465 PMID: 15911532 PMID: 20932056 PMID: 17904518 PMID: 15968066Outer Membrane LipoproteinIN/APeriplasm Outer membrane Lipoprotein(experimental)SECLOLyesyesY230.327SpII1813.0401Pos+2=V10Yn3-16c21/22oPeriplasmic995
MLAD_ECOLIP64604
mlaD

yrbD

yrbDb3193 JW3160 periplasmic protein (SEC through IM), Interphospholipid transport system binding MlaD PeriplasmicGSoluble IM FractionCell inner membrane PeriplasmicSECyesyesN290.187SpI287.17952-10Yn8-23c28/29oUnknown260
YFGH_ECOLIP65290
yfgH
b2505 JW5400 OM lipoprotein (SEC through IM, inserted in OM by LOL), YfgHOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinISoluble IM FractionCell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY270.349SpII2124.716Pos+2=Q00Yn7-17c22/23oUnknown273
YGDI_ECOLIP65292
ygdI
b2809 JW5448 OM lipoprotein (SEC through IM, inserted in OM by LOL), YgdIOuter Membrane LipoproteinOuter membrane protein determined by LC-MS (Gevaert et al 2002) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 15174130PMID: 12488465 PMID: 21541338 PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesY220.339SpII1921.6734Pos+2=S10Yn6-17c22/23oUnknown2119
YGDR_ECOLIP65294
ygdR
b2833 JW2801 OM lipoprotein (SEC through IM, inserted in OM by LOL), YgdROuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesN280.252SpII1915.677Pos+2=S10Yn6-17c22/23oUnknown2
YQHH_ECOLIP65298
yqhH
b3014 JW2982 OM lipoprotein (SEC through IM, inserted in OM by LOL), YqhHOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesN240.242SpII1915.1531Pos+2=V10Yn4-17c22/23oOuterMembrane917
BEPA_ECOLIP66948
bepA

yfgC

yfgCb2494 JW2479 periplasmic protein (SEC through IM), Beta-barrel assembly-enhancing protease BepAPeriplasmicBepA maintains the integrity of OM both by promoting assembly of OMPs and by proteolytically eliminating OMPs when their correct assembly was compromised. BepA is a metalloprotease that cleaves its targets preferentially between Phe-Phe residues. Potential Skp substrate PMID: 19953543PMID: 24003122 PMID: 22491786 PMID: 19953543 PMID: 22901060PeriplasmicGN/APeriplasm PeriplasmicSECSKPyesyesY280.636SpI2715.2429-00Yn9-19c27/28oUnknown210
YNFC_ECOLIP67553
ynfC
b1585 JW5258 IM lipoprotein (SEC through IM), inserted in OM by LOL), UPF0257 YnfCInner Membrane Lipoprotein Proven pignal peptidase II substrate.PMID: 15174130Inner Membrane LipoproteinEN/ACell membrane Inner membrane lipoproteinSECLOLyesyesN210.178SpII1614.4125Pos+2=D00Yn5-14c19/20oCytoplasmic8
RCSF_ECOLIP69411
rcsF
b0196 JW0192 OM lipoprotein (SEC through IM, inserted in OM by LOL), RcsFOuter Membrane Lipoprotein Proven pignal peptidase II substrate. Identified DsbA substrate PMID: 19953543 PMID: 15174130 Disulfide bridge (74 118;109 124) Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 16740933 PMID: 23813676 PMID: 20932056 PMID: 19953543 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionCell outer membrane Outer membrane Lipoprotein (Experimental)SECDSBALOLyesyesY230.182SpII1513.2891Pos+2=S00Yn3-13c21/22oOuterMembrane1081
PGAA_ECOLIP69434
pgaA

ycdS

ycdSb1024 JW1010 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Poly-beta-1,6-N-acetyl-D-glucosamine export PgaAOuter Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinSECBAMnoyesY330.331SpI3212.415-00Yn18-26c32/33oUnknown26
LPP_ECOLIP69776
lpp

mlpA mulI

mlpA mulIb1677 JW1667 OM lipoprotein & extra-cellular peripheral OM protein (SEC through IM, inserted in OM by LOL), LppOuter Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular spaceTrigger factor-sensitive aggregation. Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005). Covalently attached to the peptidoglycan cell wall by the ??-amino group of its C-terminal Lys residue; stabilizes the bacterial envelope. Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 PMID: 4575979PMID: 15174130 PMID: 19737520 PMID: 15911532 PMID: 21219470 PMID: 3013869 PMID: 16079137 PMID: 21541338 PMID: 4575979Outer Membrane Lipoprotein, Peripheral outer membrane protein facing the extra-cellular spaceI, F4Soluble IM FractionCell outer membrane Outer membrane Lipoprotein (Experimental)TFSECLOLyesyesY260.325SpII2026.7873Pos+2=S00Yn6-17c25/26oOuterMembrane1058
NANC_ECOLIP69856
nanC

yjhA

yjhAb4311 JW5778 periplasmic protein (SEC through IM), Probable N-acetylneuraminic acid channel NanC PeriplasmicGN/ACell outer membranePeriplasmicSECnoyesY240.708SpI2319.1942-00Yn6-15c23/24oOuterMembrane108
SFMH_ECOLIP75715
sfmH
b0533 JW5071 Fimbrial periplasmic protein (SEC through IM), SfmHPeriplasmicPotential fimbrial sfm operon (class ??1); Potential tip-adhesin. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 19820722 PMID: 20345943 PMID: 18498364PeriplasmicGN/AFimbrium CytoplasmicfimbriaeSECSURACUnoyesY190.186SpI246.26896-00Yn2-9c14/15oUnknown217
CHIP_ECOLIP75733
chiP

ybfM

ybfMb0681 JW0667 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Chitoporin ChiPOuter Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinSECBAMnoyesY330.272SpI3212.9387-00Yn10-20c32/33oUnknown21
YBFP_ECOLIP75737
ybfP
b0689 JW0676 OM lipoprotein (SEC through IM, inserted in OM by LOL), YbfPOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesY250.444SpII2215.3591Pos+2=A10Yn7-20c24/25oUnknown251
YBGO_ECOLIP75748
ybgO
b0716 JW5098 Fimbrial periplasmic protein (SEC through IM), YbgOPeriplasmicPutative chaperone???usher fimbrial operon yeh (class ??); Unkown function. Disulfide bond-containing protein PMID: 25664544PMID: 20345943 PMID: 25664544PeriplasmicGN/APeriplasmicfimbriaeSECnoyesN240.359SpI237.76951-00Yn7-18c23/24oCytoplasmic853
YBGP_ECOLIP75749
ybgP
b0717 JW0707 Fimbrial periplasmic protein (SEC through IM), Chaperone YbgPPeriplasmicPutative chaperone???usher fimbrial operon yeh (class ??); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364 PMID: 20345943PeriplasmicGN/APeriplasm PeriplasmicfimbriaeSECSURAnoyesY210.795SpI205.41341-00Yn6-16c20/21oPeriplasmic1019
YBGQ_ECOLIP75750
ybgQ
b0718 JW5099 Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), YbgQOuter Membrane b-barrel proteinPutative chaperone???usher fimbrial operon yeh (class ??); Usher. Disulfide bridge (795 814) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinfimbriaeSECBAMnoyesY220.84SpI218.29107-00Yn6-16c21/22oOuterMembrane1010
FIU_ECOLIP75780
fiu

ybiL

ybiLb0805 JW0790 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Catecholate siderophore receptor FiuOuter Membrane b-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003)','Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003, Molloy et al 2000) Potential Skp substrate PMID: 19953543 PMID: 10806384 Disulfide bond-containing protein PMID: 25664544PMID: 10806384 PMID: 20932056 PMID: 19953543 PMID: 25664544Outer Membrane b-barrel proteinHN/ACell outer membraneOuter Membrane ??-barrel protein (Experimental)SECSKPBAMyesyesY340.525SpI3311.8291-10Yn14-25c33/34oOuterMembrane1010
GSIB_ECOLIP75797
gsiB

yliB

yliBb0830 JW5111 periplasmic protein (SEC through IM), Glutathione-binding GsiB Periplasmic Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 15911532PMID: 18498364 PMID: 15911532PeriplasmicGN/APeriplasm Periplasmic(experimental)SECSURAyesyesY270.582SpI2615.0769-00Yn10-21c26/27oPeriplasmic1040
YLII_ECOLIP75804
yliI
b0837 JW0821 periplasmic protein (SEC through IM), Aldose sugar dehydrogenase YliIPeriplasmic Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/ACell outer membrane PeriplasmicSECSURAnoyesY210.629SpI209.24571-00Yn5-15c20/21oCytoplasmicMembrane921
YBJP_ECOLIP75818
ybjP
b0865 JW0849 OM lipoprotein (SEC through IM, inserted in OM by LOL), YbjPOuter Membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338 Identified DsbA substrate PMID: 19953543 PMID: 10806384 Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 15911532 PMID: 20932056 PMID: 21541338 PMID: 19953543 PMID: 10806384 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionCell membrane Outer membrane Lipoprotein (Experimental)SECDSBALOLnoyesY280.445SpII1810.6734Pos+2=T00Yn9-19c24/25oUnknown269
AMID_ECOLIP75820
amiD

ybjR

ybjRb0867 JW0851 OM lipoprotein (SEC through IM), inserted in OM by LOL), N-acetylmuramoyl-L-alanine amidase AmiD Outer Membrane LipoproteinProven pignal peptidase II substrate.PMID: 15174130Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane LipoproteinSECLOLyesyesY210.182SpII1618.0923Pos+2=A00Yn4-14c19/20oUnknown618
SSUA_ECOLIP75853
ssuA

ycbO

ycbOb0936 JW0919 periplasmic protein (SEC through IM), Putative aliphatic sulfonates-binding protein SsuAPeriplasmicPMID: 10781534PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECnoyesY220.876SpI2114.9607-00Yn7-18c22/23oUnknown276
ELFA_ECOLIP75855
elfA

ycbQ

ycbQb0938 JW5122 Fimbrial periplasmic protein (SEC through IM), subunit ElfAPeriplasmicPotential fimbrial ycb operon (class ??1); Fimbrial Subunit.PMID: 20345943 PMID: 19820722PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECCUnoyesY220.807SpI2123.0184-00Yn5-16c21/22oExtracellular1085
ELFD_ECOLIP75856
elfD

ycbR

ycbRb0939 JW0922 Fimbrial periplasmic protein (SEC through IM), Probable chaperone ElfDPeriplasmicPotential fimbrial ycb operon (class ??1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasm PeriplasmicfimbriaeSECSURAyesyesY270.835SpI2618.1825-00Yn10-21c26/27oUnknown629
ELFC_ECOLIP75857
elfC

ycbS

ycbSb0940 JW0923 Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), Probable usher ElfC Outer Membrane b-barrel proteinPotential fimbrial ycb operon (class ??1); Usher.PMID: 20345943Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinfimbriaeSECBAMyesyesN360.312SpI356.8393-10Yn19-30c35/36oOuterMembrane107
ELFG_ECOLIP75858
elfG

ycbT

ycbTb0941 JW0924 Fimbrial periplasmic protein (SEC through IM), ElfGPeriplasmicPotential fimbrial ycb operon (class ??1); Potential tip-adhesin.PMID: 19820722 PMID: 20345943 PMID: 21890895PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECCUnoyesY310.334SpI305.91464-10Yn15-25c30/31oExtracellular932
YCBU_ECOLIP75859
ycbU
b0942 JW0925 Fimbrial periplasmic protein (SEC through IM), YcbUPeriplasmicPotential fimbrial ycb operon (class ??1); Fimbrial Subunit. Ycb operon is homolog to fim operon (ycbv is fimI homolog).PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECCUnoyesY250.653SpI245.70567-10Yn6-17c24/25oExtracellular941
YCBV_ECOLIP75860
ycbV
b0943 JW5123 Fimbrial periplasmic protein (SEC through IM), YcbVPeriplasmicPotential fimbrial ycb operon (class ??1); Fimbrial Subunit. Ycb operon is homolog to fim operon (ycbv is fimI homolog).PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECCUnoyesN230.301SpI225.04607-00Yn6-17c22/23oUnknown247
GFCD_ECOLIP75882
gfcD

ymcA

ymcAb0984 JW0967 periplasmic protein (SEC through IM), GfcDPeriplasmicGN/ACell membrane PeriplasmicSECyesyesY220.783SpI2117.8352-00Yn7-15c21/22oOuterMembrane9
GFCB_ECOLIP75884
gfcB

ymcC

ymcCb0986 JW0969 OM lipoprotein (SEC through IM, inserted in OM by LOL), GfcBOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesY200.315SpII1511.1657Pos+2=T00Yn4-14c19/20oCytoplasmicMembrane937
PGAB_ECOLIP75906
pgaB

ycdR

ycdRb1023 JW5142 OM lipoprotein (SEC through IM), inserted in OM by LOL), Poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaBOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesN260.161SpII2014.5441Pos+2=I00Yn9-20c25/26oPeriplasmic915
FLGA_ECOLIP75933
flgA
b1072 JW1059 periplasmic protein (SEC through IM), Flagella basal body P-ring formation FlgA PeriplasmicPeriplasmic chaperone for P ring protein. PMID: 12730325PMID: 12631703 PMID: 12730325PeriplasmicGN/APeriplasm Periplasmic (Experimental)SEC FlayesyesY220.722SpI215.00523-00Yn8-16c21/22oPeriplasmic912
YCFS_ECOLIP75954
ycfS
b1113 JW5820 periplasmic peripheral OM protein (SEC through IM), Probable L,D-transpeptidase YcfSPeripheral outer membrane protein facing the periplasmPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. YcfS has been shown to crosslink Braun's lipoprotein (Lpp) to the peptidoglycan.PMID: 18498364 PMID: 23832002Peripheral outer membrane protein facing the periplasmF3N/APeriplasm PeriplasmicSECSURAyesyesY290.319SpI2814.2493-10Yn11-24c28/29oUnknown263
PLIG_ECOLIP76002
pliG

ycgK

ycgKb1178 JW1167 periplasmic protein (SEC through IM), Inhibitor of g-type lysozyme PliGPeriplasmicSecB substrate. Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 16352602 PMID: 20734102 PMID: 25403562PeriplasmicGN/APeriplasm PeriplasmicSECBSECnoyesY230.798SpI2219.6754-00Yn9-17c22/23oUnknown272
YCJN_ECOLIP76042
ycjN
b1310 JW1303 OM lipoprotein (SEC through IM), inserted in OM by LOL), Putative ABC transporter periplasmic-binding YcjN Outer Membrane LipoproteinPhobius prediction hydrophobic region around residue 400 with transmembrane probability equal to 0.8. Minor prediction of weak transmembrane region in the same region by TMHMM . Otherwise no obvious signals. Homologous to P28904 (TREC_ECOLI) Trehalose-6-phosphate hydrolase that is totally soluble and cytoplasmic Wikipedia classifies Categories: Transferases | EC 2.4.1 | Peripheral membrane proteins. In Streptococcus Jaecalis it is not found associated with the membrane. Proven pignal peptidase II substrate. PMID: 15174130PMID: 13859056 PMID: 15660210 PMID: 15174130Outer Membrane LipoproteinIN/APeriplasm Outer membrane Lipoprotein (Experimental)SECLOLnoyesN200.189SpII2013.8019Pos+2=K00Yn6-17c21/22oUnknown266
OMPG_ECOLIP76045
ompG
b1319 JW1312 OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpGOuter Membrane b-barrel protein Proteoliposome swelling assays showed that OmpG channels were much larger than those of the OmpF and OmpC porins, with an estimated limited diameter of about 2 nm. PMID: 9721282 Potential Skp substrate PMID: 19953543 PMID: 9721282PMID: 9721282 PMID: 19953543Outer Membrane b-barrel proteinHN/ACell outer membrane; Multi-pass membrane proteinOuter Membrane ??-barrel protein (Experimental)SECSKPBAMnoyesY200.465SpI2114.867-00Yn4-14c19/20oOuterMembrane1054
YDCS_ECOLIP76108
ydcS
b1440 JW1435 periplasmic protein (SEC through IM), Bifunctional polyhydroxybutyrate synthase / ABC transporter periplasmic binding YdcSPeriplasmic Potential substrate for the SRP pathway. It was found to be down-regulated in the periplasmic compartment of SRP-depleted cells. PMID: 22030350 Disulfide bond-containing protein PMID: 25664544PMID: 15911532 PMID: 22030350 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECnoyesY230.836SpI2217.8592-00Yn10-18c22/23oPeriplasmic1016
YNCD_ECOLIP76115
yncD
b1451 JW1446 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Probable TonB-dependent receptor YncD Outer Membrane b-barrel proteinOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005, Fountoulakis et al 2003) Potential Skp substrate PMID: 19953543PMID: 12624733 PMID: 20932056 PMID: 19953543Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinSECSKPBAMnoyesY240.888SpI2312.8703-00Yn10-18c23/24oOuterMembrane102
YNCE_ECOLIP76116
yncE
b1452 JW1447 periplasmic protein (SEC through IM), YncEPeriplasmicSecB substrate.PMID: 16352602PeriplasmicGN/APeriplasmicSECBSECnoyesY310.794SpI3016.4204-00Yn15-26c30/31oUnknown264
DDPA_ECOLIP76128
ddpA

yddS

yddSb1487 JW5240 periplasmic protein (SEC through IM), Probable D,D-dipeptide-binding periplasmic DdpA PeriplasmicPMID: 11121068PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECnoyesY260.839SpI2519.0002-00Yn10-17c25/26oPeriplasmic1061
LSRB_ECOLIP76142
lsrB

yneA

yneAb1516 JW1509 periplasmic protein (SEC through IM), Autoinducer 2-binding LsrBPeriplasmicPMID: 15601708PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECnoyesY270.845SpI2621.9126-00Yn9-20c26/27oPeriplasmic1075
YNFB_ECOLIP76170
ynfB
b1583 JW1575 periplasmic peripheral OM protein (SEC through IM), UPF0482 YnfBPeripheral outer membrane protein facing the periplasmOuter membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) Disulfide bond-containing protein PMID: 25664544PMID: 15911532 PMID: 25664544Peripheral outer membrane protein facing the periplasmF3N/APeriplasmicSECyesyesY290.87SpI2819.5483-00Yn9-20c28/29oUnknown249
YDGD_ECOLIP76176
ydgD
b1598 JW1590 periplasmic (SEC through IM) serine protease YdgD PeriplasmicGN/APeriplasmicSECyesyesY220.691SpI2115.015-00Yn3-14c21/22oUnknown228
YDGH_ECOLIP76177
ydgH
b1604 JW1596 periplasmic protein (SEC through IM), YdgHPeriplasmicGN/APeriplasmicSECyesyesY230.805SpI2222.3224-00Yn7-18c22/23oUnknown213
MEPH_ECOLIP76190
mepH

ydhO

ydhOb1655 JW5270 periplasmic protein (SEC through IM), Murein DD-endopeptidase MepH PeriplasmicGN/APeriplasmicSECyesyesY280.421SpI2715.3587-00Yn8-19c27/28oUnknown6
YNHG_ECOLIP76193
ynhG
b1678 JW1668 periplasmic peripheral OM protein (SEC through IM), Probable L,D-transpeptidase YnhGPeripheral outer membrane protein facing the periplasmPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. YnhG forms direct meso- diaminopimelate (DAP-DAP, or 3-3) crosslinks within the peptidoglycan.PMID: 18498364 PMID: 23832002Peripheral outer membrane protein facing the periplasmF3N/APeriplasm PeriplasmicSECSURAyesyesY240.48SpI2315.3547-00Yn4-15c23/24oPeriplasmic922
YDJY_ECOLIP76220
ydjY
b1751 JW5283 IM lipoprotein (SEC through IM, inserted in OM by LOL), YdjYInner Membrane LipoproteinInner Membrane LipoproteinESoluble IM FractionInner membrane lipoproteinSECLOLnoyesN340.346SpII2615.9526Pos+2=D00Yn13-24c29/30oUnknown296
YNJB_ECOLIP76223
ynjB
b1754 JW5284 periplasmic protein (SEC through IM), YnjBPeriplasmic Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAnoyesY210.688SpI2011.9034-00Yn4-16c20/21oUnknown270
YEDS_ECOLIP76335
yedS
b4496 JW5319/JW1948/JW1949 b1964/b1965/b1966OM b-barrel protein (SEC through IM, inserted in OM by BAM), Putative YedSOuter Membrane b-barrel proteinHN/ACell outer membrane CytoplasmicSECBAMpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)yesnoY220.864SpI2122.1485-00Yn5-16c21/22oOuterMembrane1018
HIUH_ECOLIP76341
hiuH

yedX

yedXb1970 JW1953 periplasmic protein (SEC through IM), 5-hydroxyisourate hydrolase HiuHPeriplasmicPMID: 12542701PeriplasmicGN/APeriplasm PeriplasmicSECyesyesY240.79SpI2318.1944-00Yn6-17c23/24oUnknown278
ZINT_ECOLIP76344
zinT

yodA

yodAb1973 JW1956 periplasmic protein (SEC through IM), Metal-binding ZinT PeriplasmicAfter 45 min of cadmium exposure the YodA protein was primarily detected in the cytoplasmic fraction but was later (150 min) found in both the cytoplasmic and periplasmic compartments. PMID: 9579078 Disulfide bond-containing protein PMID: 25664544PMID: 12480884 PMID: 9579078 PMID: 25664544PeriplasmicGN/ACytoplasm Periplasmic (Experimental)SECyesyesY240.683SpI2312.2997-00Yn8-18c23/24oUnknown2
YEEJ_ECOLIP76347
yeeJ
b1978 JW5833 OM b-barrel protein (SEC through IM, inserted in OM by BAM), YeeJOuter Membrane b-barrel proteinCytplasmic transciption factor that shuttles from chromosome to the membranes as a peripheral protein on the PtsG transporter. Specifically it binds to the unphosphorylated, tRNAs port-mediating form of the EIIBCGl subunit. PMID: 15063852Outer Membrane b-barrel proteinHN/ACytoplasmicSECBAMnoyesN520.258SpI451.97486-00Yn27-39c51/52oOuterMembrane9
YFAP_ECOLIP76462
yfaP
b2225 JW2219 periplasmic protein (SEC through IM), YfaPPeriplasmic Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAyesyesY200.599SpI1913.0156-00Yn4-14c19/20oUnknown2107
YFAQ_ECOLIP76463
yfaQ
b2226 JW2220 periplasmic protein (SEC through IM), YfaQPeriplasmic Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAnoyesY200.66SpI198.15864-00Yn6-15c19/20oUnknown29
YFAS_ECOLIP76464
yfaS

yfaR

yfaRb4500 JW2221/JW2222 b2227/b2228periplasmic protein (SEC through IM), Putative alpha-2-macroglobulin homolog YfaSPeriplasmic Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGSoluble IM FractionPeriplasmicSECSURApseudogene (Ochman & Davalos, 2006), pseudogene (Uniprot)noyesY390.71SpI3814.0209-00Yn20-31c38/39oUnknown481
YFAZ_ECOLIP76471
yfaZ
b2250 JW5371 OM b-barrel protein (SEC through IM, inserted in OM by BAM), YfaZOuter Membrane b-barrel proteinPMID: 20932056Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinSECBAMnoyesY220.713SpI2119.9632-00Yn4-15c21/22oUnknown278
YFBK_ECOLIP76481
yfbK
b2270 JW2265 IM lipoprotein (SEC through IM, inserted in OM by LOL), YfbKInner Membrane LipoproteinEN/AMembrane LipoproteinSECLOLnoyesN240.119SpII1827.352Pos+2=G00Yn6-16c21/22oUnknown249
YFCO_ECOLIP76498
yfcO
b2332 JW2329 Fimbrial periplasmic protein (SEC through IM), YfcOPeriplasmicPutative chaperone???usher fimbrial operon yfc (class ??); Unkown functionPMID: 20345943PeriplasmicGSoluble IM FractionPeriplasmicfimbriaeSECnoyesY220.835SpI2114.5584-00Yn6-16c21/22oExtracellular941
YFCP_ECOLIP76499
yfcP
b2333 JW2330 Fimbrial periplasmic protein (SEC through IM), YfcPPeriplasmicPutative chaperone???usher fimbrial operon yfc (class ??); Fimbrial Subunit. Disulfide bridge (43 83) PMID: 19820722 PMID: 20345943 PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECCUyesyesY280.79SpI2714.214-10Yn8-19c27/28oUnknown2
YFCQ_ECOLIP76500
yfcQ
b2334 JW2331 Fimbrial periplasmic protein (SEC through IM), YfcQPeriplasmicPutative chaperone???usher fimbrial operon yfc (class ??); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECyesyesY190.841SpI1813.6429-00Yn4-11c18/19oUnknown296
YFCR_ECOLIP76501
yfcR
b2335 JW2332 Fimbrial periplasmic protein (SEC through IM), YfcRPeriplasmicPutative chaperone???usher fimbrial operon yfc (class ??); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECyesyesY290.68SpI2811.4125-00Yn10-22c30/31oUnknown249
MLAA_ECOLIP76506
mlaA

vacJ

vacJb2346 JW2343 OM lipoprotein (SEC through IM), inserted in OM by LOL), Interphospholipid transport system MlaA Outer Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY220.16SpII1720.7085Pos+2=A00Yn5-16c21/22oOuterMembrane919
YFEY_ECOLIP76537
yfeY
b2432 JW2425 OM lipoprotein (SEC through IM, inserted in OM by LOL), YfeYOuter Membrane Lipoprotein Proven pignal peptidase II substrate. Outer membrane protein determined by LC-MS (Gevaert et al 2002) PMID: 15174130 Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 12488465 PMID: 20932056 PMID: 25664544Outer Membrane LipoproteinIN/AOuter membrane Lipoprotein (Experimental)SECLOLyesyesY290.248SpII1720.3796Pos+2=S00Yn8-19c27/28oUnknown259
YPFG_ECOLIP76559
ypfG
b2466 JW2450 periplasmic protein (SEC through IM), YpfGPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/APeriplasmicSECyesyesY220.804SpI2115.2807-10Yn5-16c21/22oCytoplasmicMembrane961
YFHM_ECOLIP76578
yfhM
b2520 JW2504 IM lipoprotein (SEC through IM), inserted in OM by LOL), Alpha-2-macroglobulin YfhMInner Membrane Lipoprotein Identified DsbA substrate PMID: 19953543PMID: 19953543Inner Membrane LipoproteinESoluble IM FractionCell inner membrane Inner membrane lipoproteinSECDSBALOLyesyesY250.18SpII1728.7232Pos+2=D00Yn6-13c18/19oUnknown4
YQIG_ECOLIP76655
yqiG
b3046 JW5507 Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), Putative usher YqiG Outer Membrane b-barrel proteinPutative chaperone???usher fimbrial operon (class ??); Usher. Disulfide bridge (798 817) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinfimbriaeSECBAMpseudogene (Uniprot)noyesN210.333CYT0-0.200913-00NiOuterMembrane10
YQII_ECOLIP76656
yqiI
b3048 JW5509 Fimbrial periplasmic protein (SEC through IM), YqiIPeriplasmicPutative chaperone???usher fimbrial operon (class ??); Unknown function.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY220.868SpI2114.4478-00Yn4-14c21/22oUnknown285
OMPL_ECOLIP76773
ompL

yshA

yshAb3875 JW3846 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Porin OmpL Outer Membrane b-barrel proteinPMID: 11080145Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel protein (Experimental)SECBAMnoyesY210.672SpI2013.4725-00Yn6-16c20/21oOuterMembrane106
ECPB_ECOLIP77188
ecpB

matC yagY

matC yagYb0292 JW0286 Fimbrial periplasmic protein (SEC through IM), Probable chaperone EcpBPeriplasmicPutative chaperone???usher fimbrial operon yag(class ??); Unknown function.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECnoyesY210.828SpI2012.558-00Yn5-15c20/21oUnknown225
YFCU_ECOLIP77196
yfcU

yfcT

yfcTb4661 JW2334/JW2335 b2337 b2338Fimbrial OM b-barrel protein (SEC through IM), Putative usher YfcU Outer Membrane b-barrel proteinHN/ACell outer membrane CytoplasmicfimbriaeSECpseudogene (Ochman & Davalos, 2006), pseudogene (Uniprot)noyesY300.624SpI295.84101-00Yn11-21c29/30oOuterMembrane1079
YAIT_ECOLIP77199
yaiT
b4580 JW0362/JW5051 b0371 b0374OM b-barrel protein (SEC through IM), T5S secreted through OM), Putative YaiTOuter Membrane b-barrel proteinAg43 homologue; predicted autotransporter. Contains autotransporter beta-domain <a href="http://www.ebi.ac.uk/interpro/entry/IPR005546/proteins-matched?species=83333">(IPR005546)</a>. Potential Srp-dependent autotransporter. Homologous to hemoglobin-binding protease hbp. Hbp is the only known autotransporter that is secreted through the integral membrane in a Srp-dependent manner.PMID: 15590781 PMID: 12466262Outer Membrane b-barrel proteinHN/APeriplasmicSRPSECAutotransporter(T5S)pseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoY280.844SpI2723.6574-00Yn8-19c27/28oUnknown555
DSBG_ECOLIP77202
dsbG

ybdP

ybdPb0604 JW0597 periplasmic protein (SEC through IM), Thiol:disulfide interchange DsbG Periplasmic Disulfide bridge (126 129) PMID: 15184683 Disulfide bond-containing protein PMID: 25664544PMID: 9383195 PMID: 15184683 PMID: 25664544PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY180.618SpI1712.1105-00Yn5-12c17/18oPeriplasmic1050
CUSC_ECOLIP77211
cusC

ibeB ylcB

ibeB ylcBb0572 JW0561 OM lipoprotein (SEC through IM), inserted in OM by LOL), Cation efflux system CusCOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 21249122 PMID: 20932056Outer Membrane LipoproteinIN/ACell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY220.405SpII1711.8848Pos+2=S00Yn6-15c20/21oOuterMembrane1027
CUSB_ECOLIP77239
cusB

ylcD

ylcDb0574 JW0563 periplasmic peripheral IM protein (SEC through IM), Cation efflux system CusBPeripheral inner membrane protein facing the periplasmMFP family function as auxiliary proteins or 'adaptors', connecting a primary porter in the cytoplasmic membrane of a Gram-negative bacterium with an outer membrane factor (OMF; TC #1.B.17) protein that serves a porin or channel function in the outer membrane.PMID: 19695261Peripheral inner membrane protein facing the periplasmF2N/AMembrane anchoredSECyesyesN290.243SpI287.5302-10Yn4-16c28/29oUnknown256
SFMC_ECOLIP77249
sfmC
b0531 JW0520 Fimbrial periplasmic protein (SEC through IM), Probable chaperone SfmCPeriplasmicPotential fimbrial sfm operon (class ??1); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Might be is co-translationally translocated through Sec translocon. The precursor of SfmC harbouring hydrophobic signal sequence require SRP and FtsY in addition to SecA for maximal translocation. PMID: 24717922 The precursor of SfmC harbouring hydrophobic signal sequence require SRP and FtsY in addition to SecA for maximal translocation. PMID: 24717922 Potential substrate for the SRP pathway. When fused to cytoplasmic protein thioredoxin promotes signal recognition particle-dependent translocation PMID: 15838024PMID: 18498364 PMID: 20345943 PMID: 15838024 PMID: 24717922PeriplasmicGN/APeriplasm PeriplasmicfimbriaeSRP (exp)SECSURAyesyesY240.844SpI2314.9715-10Yn7-18c23/24oPeriplasmic1028
ECPE_ECOLIP77263
ecpE

matF yagV

matF yagVb0289 JW5030 Fimbrial periplasmic protein (SEC through IM), Probable chaperone EcpEPeriplasmicPutative chaperone???usher fimbrial operon yag(class ??); Unknown function. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Disulfide bond-containing protein PMID: 25664544PMID: 18498364 PMID: 20345943 PMID: 25664544PeriplasmicGN/APeriplasmicfimbriaeSECSURAnoyesY280.534SpI278.52618-10Yn12-22c27/28oUnknown217
YPHF_ECOLIP77269
yphF
b2548 JW2532 periplasmic protein (SEC through IM), ABC transporter periplasmic-binding YphFPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 9298646 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECnoyesY270.817SpI2620.8859-00Yn11-22c26/27oPeriplasmic963
RSXG_ECOLIP77285
rsxG

rnfG ydgP

rnfG ydgPb1631 JW1623 periplasmic protein (SEC through IM), Ion-translocating oxidoreductase complex subunit G RsxGPeriplasmic Disulfide bond-containing protein PMID: 25664544PMID: 25664544PeriplasmicGN/ACell inner membrane PeriplasmicSECyesyesY250.427SpI2411.9411-00Yn9-17c24/25oUnknown242
YFCV_ECOLIP77288
yfcV
b2339 JW2336 Fimbrial periplasmic protein (SEC through IM), YfcVPeriplasmicPutative chaperone???usher fimbrial operon yfc (class ??); Fimbrial Subunit.PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECCUyesyesY260.533SpI2514.9857-10Yn7-18c25/26oUnknown297
YDER_ECOLIP77294
ydeR
b1503 JW1497 Fimbrial periplasmic protein (SEC through IM), YdeRPeriplasmicPotential fimbrial yde operon (class ??1); Fimbrial Subunit. Disulfide bridge (39 77) PMID: 19820722 PMID: 20345943 PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECCUnoyesY240.701SpI2320.0135-00Yn8-18c23/24oUnknown267
YBET_ECOLIP77296
ybeT
b0647 JW0642 OM lipoprotein (SEC through IM), inserted in OM by LOL), Sel1-repeat-containing YbeT Outer Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLnoyesN220.112SpII185.89834Pos+2=I10Yn8-17c21/22oUnknown249
YDEN_ECOLIP77318
ydeN
b1498 JW5243 periplasmic protein (SEC through IM), sulfatase YdeNPeriplasmicGN/APeriplasmicSECnoyesY300.809SpI2924.3093-00Yn9-20c29/30oUnknown656
BORD_ECOLIP77330
borD

ybcU

ybcUb0557 JW0546 OM lipoprotein (SEC through IM), inserted in OM by LOL), Prophage Bor homolog BorDOuter Membrane LipoproteinProven pignal peptidase II substrate. PMID: 15174130 Disulfide bond-containing protein PMID: 25664544PMID: 15174130 PMID: 25664544Outer Membrane LipoproteinISoluble IM FractionCell membrane Outer membrane Lipoprotein (Experimental)SECLOLProphage Integrase (EcoGene)nonoY210.303SpII1621.3732Pos+2=A00Yn5-14c18/19oUnknown232
YAFT_ECOLIP77339
yafT
b0217 JW0206 OM lipoprotein (SEC through IM, inserted in OM by LOL), YafTOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLnoyesY210.197SpII1823.0916Pos+2=A00Yn6-16c21/22oUnknown261
MPPA_ECOLIP77348
mppA

ynaH

ynaHb1329 JW1322 periplasmic protein (SEC through IM), murein peptide-binding protein MppAPeriplasmicPMID: 9495761PeriplasmicGN/APeriplasmPeriplasmic (Experimental)SECyesyesY230.7SpI228.93006-00Yn4-14c22/23oPeriplasmic1032
YBCL_ECOLIP77368
ybcL
b0545 JW0533 periplasmic protein (SEC through IM), UPF0098 YbcLPeriplasmic Disulfide bridge (46 129) Disulfide bond-containing protein PMID: 25664544PMID: 11439028 PMID: 25664544PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECProphage Integrase (EcoGene)yesnoY200.717SpI1919.8157-00Yn4-15c19/20oPeriplasmic1048
SFMD_ECOLIP77468
sfmD
b0532 JW0521 Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), SfmDOuter Membrane b-barrel proteinPotential fimbrial sfm operon (class ??1); Usher. Disulfide bridge (840 862) PMID: 20345943 Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel proteinfimbriaeSECBAMyesyesN360.404TMH03.9822-11Ni12-32oOuterMembrane10
YAIW_ECOLIP77562
yaiW
b0378 JW0369 OM lipoprotein (SEC through IM, inserted in OM by LOL), YaiWOuter Membrane Lipoprotein Disulfide bond-containing protein PMID: 25664544PMID: 20932056 PMID: 25664544Outer Membrane LipoproteinIN/AOuter membrane LipoproteinSECLOLnoyesY260.354SpII2028.9818Pos+2=S00Yn7-18c23/24oUnknown210
YDEQ_ECOLIP77588
ydeQ
b1502 JW1496 Fimbrial periplasmic protein (SEC through IM), YdeQPeriplasmicPotential fimbrial yde operon (class ??1); Potential tip-adhesin.PMID: 19820722 PMID: 20345943 PMID: 18498364PeriplasmicGN/AFimbrium PeriplasmicfimbriaeSECSURACUnoyesN250.739SpI2410.2575-00Yn9-19c24/25oUnknown261
YFCS_ECOLIP77599
yfcS
b2336 JW2333 Fimbrial periplasmic protein (SEC through IM), Probable chaperone YfcSPeriplasmicPutative chaperone???usher fimbrial operon yfc (class ??); Chaperone. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasm PeriplasmicfimbriaeSECSURAyesyesY290.747SpI2811.2467-00Yn10-21c28/29oPeriplasmic1077
YQIH_ECOLIP77616
yqiH
b3047 JW5508 Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), Chaperone YqiHOuter Membrane b-barrel proteinPutative chaperone???usher fimbrial operon (class ??); Chaperone.PMID: 20345943Outer Membrane b-barrel proteinHN/APeriplasm Outer Membrane ??-barrel proteinfimbriaeSECBAMnoyesY260.426SpI2512.7072-10Yn9-20c25/26oPeriplasmic1021
YFEW_ECOLIP77619
yfeW
b2430 JW5395 periplasmic protein (SEC through IM), UPF0214 YfeWPeriplasmicGN/APeriplasmicSECnoyesY200.512SpI1910.3062-00Yn6-14c19/20oPeriplasmic9
ECPD_ECOLIP77694
ecpD

matE yagW

matE yagWb0290 JW0284 Fimbrial OM b-barrel protein (SEC through IM, inserted in OM by BAM), Fimbria adhesin EcpD EcpDOuter Membrane b-barrel proteinPutative chaperone???usher fimbrial operon yag(class ??); Unknown function. Putative Outer membrane protein (BOMB prediction + SignalP 98% prediction).PMID: 20345943Outer Membrane b-barrel proteinHN/AFimbrium CytoplasmicfimbriaeSECBAMnoyesN320.295SpI237.3263-00Yn5-16c23/24oUnknown42
YBAY_ECOLIP77717
ybaY
b0453 JW0443 OM lipoprotein (SEC through IM, inserted in OM by LOL), YbaYOuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130Outer Membrane LipoproteinIN/ACell membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY180.379SpII1821.022Pos+2=A00Yn3-14c19/20oPeriplasmic9
OMPN_ECOLIP77747
ompN

ynaG

ynaGb1377 JW1371 OM b-barrel protein (SEC through IM, inserted in OM by BAM), OmpNOuter Membrane b-barrel proteinPMID: 20932056 PMID: 9642192Outer Membrane b-barrel proteinHN/ACell outer membrane; Multi-pass membrane proteinOuter Membrane ??-barrel protein (Experimental)SECBAMyesyesY220.895SpI2124.6239-00Yn5-16c21/22oOuterMembrane1010
SPY_ECOLIP77754
spy
b1743 JW1732 periplasmic protein (SEC through IM), chaperone Spy PeriplasmicPMID: 9068658PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECyesyesY240.817SpI2320.7622-00Yn4-15c23/24oPeriplasmic10104
BAMB_ECOLIP77774
bamB

yfgL

yfgLb2512 JW2496 OM lipoprotein (SEC through IM, inserted in OM by LOL), assembly factor BamBOuter Membrane LipoproteinPart of bam complex. Interacts directry with BamA. Proven pignal peptidase II substrate. Outer membrane protein determined by 2D gel electrophoresis (Lopez-Campistrous et al 2005) PMID: 15174130PMID: 15174130 PMID: 15851030 PMID: 21823654 PMID: 21236263 PMID: 21370981 PMID: 15911532 PMID: 20932056Outer Membrane LipoproteinISoluble IM FractionCell outer membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesY270.152SpII1914.7873Pos+2=S00Yn6-17c25/26oOuterMembrane10
YDES_ECOLIP77789
ydeS
b1504 JW1498 Fimbrial extra-cellular peripheral OM protein (SEC through IM, chaperone usher export system over OM), YdeSPeripheral outer membrane protein facing the extra-cellular spacePotential fimbrial yde operon (class ??1); Fimbrial Subunit. Disulfide bridge (38 78) PMID: 19820722 PMID: 20345943 Peripheral outer membrane protein facing the extra-cellular spaceF4N/AFimbrium Membrane anchoredfimbriaeSECCUnoyesY230.426SpI2211.5353-10Yn6-17c22/23oExtracellular1079
ECPC_ECOLIP77802
ecpC

matD yagX

matD yagXb0291 JW0285 Fimbrial periplasmic protein (SEC through IM), Probable usher EcpC PeriplasmicPutative chaperone???usher fimbrial operon yag(class ??); Usher. Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364 PMID: 20345943PeriplasmicGN/APeriplasmicfimbriaeSECSURAnoyesY300.522SpI291.61886-00Yn12-23c29/30oUnknown4
YDGA_ECOLIP77804
ydgA
b1614 JW1606 periplasmic peripheral IM protein (SEC through IM), YdgAPeripheral inner membrane protein facing the periplasm Identified in nucleoids collected by sucrose gradient centrifugation and analyzed by liquid chromatography-mass spectrometry/mass spectrometry (LC-MS/MS). PMID: 21541338PMID: 16079137 PMID: 21541338Peripheral inner membrane protein facing the periplasmF2Soluble IM FractionCell inner membrane CytoplasmicSECyesyesN250.174SpI243.81151-10Yn4-14c19/20oCytoplasmicMembrane1025
YNJE_ECOLIP78067
ynjE
b1757 JW5287 periplasmic protein (SEC through IM), Thiosulfate sulfurtransferase YnjE Periplasmic Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. Potential substrate of periplasmic chaperone YfgM. PMID: 25403562 Putative substrate for the periplasmic chaperone YfgM. PMID: 25403562PMID: 18498364 PMID: 25403562PeriplasmicGN/APeriplasm PeriplasmicSECSURA,YfgMyesyesY240.698SpI2321.4185-00Yn8-18c23/24oPeriplasmic1040
YGEQ_ECOLIQ46797
ygeQ
b2863 JW5461 periplasmic protein (SEC through IM), YgeQPeriplasmicGN/APeriplasmicSECpseudogene (Uniprot), pseudogene (Ochman & Davalos, 2006)nonoY370.449SpI3611.1359-00Yn20-31c36/37oUnknown268
YGER_ECOLIQ46798
ygeR
b2865 JW2833 OM lipoprotein (SEC through IM, inserted in OM by LOL), YgeROuter Membrane Lipoprotein Proven pignal peptidase II substrate. PMID: 15174130PMID: 15174130 PMID: 20932056Outer Membrane LipoproteinIN/ACell inner membrane Outer membrane Lipoprotein (Experimental)SECLOLyesyesN330.262SpII2522.1379Pos+2=S00Yn11-23c28/29oOuterMembrane958
YGHF_ECOLIQ46834
yghF
b2970 JW5484 periplasmic protein (SEC through IM), Putative type II secretion system C-type YghFPeriplasmicGN/APeriplasm CytoplasmicSECpseudogene (Uniprot)noyesN430.145SpI161.1016-00Yn2-9c14/15oCytoplasmicMembrane936
YQHG_ECOLIQ46858
yqhG

yqhF

yqhFb3013 JW5500 periplasmic protein (SEC through IM), YqhGPeriplasmicPotential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P].PMID: 18498364PeriplasmicGN/APeriplasmicSECSURAnoyesY190.889SpI1817.8226-00Yn3-14c18/19oUnknown484
YGIS_ECOLIQ46863
ygiS
b3020 JW2988 periplasmic protein (SEC through IM), Probable deoxycholate-binding periplasmic YgiS PeriplasmicGN/APeriplasm PeriplasmicSECyesyesY210.755SpI2013.5931-00Yn6-16c20/21oPeriplasmic927
YAFL_ECOLIQ47151
yafL
b0227 JW0217 periplasmic protein (SEC through IM), Probable endopeptidase YafL PeriplasmicGN/ACell membrane PeriplasmicSECyesyesY260.582SpI2711.7588-10Yn8-19c37/38oUnknown434
YAIO_ECOLIQ47534
yaiO
b0358 JW0349 periplasmic protein (SEC through IM), YaiO<a href="http://beta-barrel.tulane.edu/">TMBB-DB</a> tool predicts this protein as an outer membrane beta barrel protein.PeriplasmicGN/ACell outer membrane PeriplasmicSECnoyesY200.841SpI1912.701-10Yn5-15c19/20oUnknown25
TAUA_ECOLIQ47537
tauA

ssiA yaiR

ssiA yaiRb0365 JW0357 periplasmic protein (SEC through IM), Taurine-binding periplasmic TauAPeriplasmicPMID: 8774726PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECnoyesY230.816SpI2216.0488-00Yn8-18c22/23oPeriplasmic9
SAPA_ECOLIQ47622
sapA
b1294 JW1287 periplasmic protein (SEC through IM), Probable ABC transporter periplasmic-binding SapA Periplasmic Potential substrate of periplasmic peptidyl prolyl cis???trans isomerase SurA; sequence contains known binding motif of SurA [RYEF]X[RYEF][P]. PMID: 9593292PMID: 18498364 PMID: 9593292PeriplasmicGN/APeriplasm Periplasmic (Experimental)SECSURAyesyesY220.865SpI2114.8036-00Yn4-15c21/22oPeriplasmic1030
UIDC_ECOLIQ47706
uidC

gusC

gusCb1615 JW1607 OM b-barrel protein (SEC through IM, inserted in OM by BAM), Membrane-associated UidC UidCOuter Membrane b-barrel proteinPMID: 15774881Outer Membrane b-barrel proteinHN/ACell outer membrane Outer Membrane ??-barrel protein (Experimental)SECBAMnoyesY240.665SpI2313.3065-10Yn4-15c23/24oOuterMembrane93