Homologous proteins of type three secretion system (T3SS) in pathogens and the flagellum

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T3SS in pathogenic bacteria Flagellar T3SS
Mammalian pathogensss Plant pathogens
Structural sub assembly of injectisome Subunit function/role Common name EPEC P. aeruginosa T3SS Yersinia T3SS Shigella flexneri Salmonella sp. SPI 1 Salmonella enterica SPI 2 Chlamydia pneumoniae Bordetella P. syringae R. solanacearum Xanthomonas spp. B. pseudomallei T3SS3 Yersinia
Pestis
F1F0 ATPase
Translocators Translocon pore protein SctE 10 EspD - B7UM93 PopB 11 YopB IpaB SipB SseC CopB1/2 14, 15 BopB 19 HrpK 24 PopF1/PopF2 HrpK 24 BipB 13 - -
Translocators Translocon pore protein SctB 10 EspB - Q05129 PopD 11 YopD IpaC SipC SseD CopD1/2 15 BopD 19 - XopA 24 XopA 24 BipC 13 - -
Translocators Tip/filament protein SctA 10 EspA - B7UM94 PcrV 11 LcrV IpaD SipD SseD CT584 or LcrV 14, 15 Bsp22 21 - - - BipD 13 FliC 25 -
Needle Needle component SctF 10 EscF - B7UM90 PscF 11 YscF MxiH PrgI SsaG CdsF 14, 15 BscF 20 HrpA HrpY HrpE 24 BsaL 13 - -
OM ring Secretin SctC 10 EscC - B7UMB3 PscC 11 YscC MxiD InvG SsaC CdsC 14, 15 BscC 20 HrcC 24 HrcC 24 HrcC 24 BsaO 13 FlgI/FlgH * 26 -
- Pilotin - - ExsB 11 VirG MxiM InvH - - BscW 20 - - - - - -
OM-IM connector Inner rod SctI 10 EscI - B7UMB0 PscI 11 YscI MxiI PrgJ SsaI - BscI 20 HrpB HrpJ HrpB2 24 BsaK 13 FlgB/FlgC/FlgF/FlgG 27 -
Accessory enzyme Muramidase - EtgA - B7UMB7 - YsaH 13 IpgF 13 IagB 13 IagB 13 - - HrpH - - BapC 13 - -
IM ring Lipoprotein ring component SctJ 10 EscJ - B7UMB1 PscJ 11 YscJ MxiJ PrgK SsaJ CdsJ 15 BscJ 20 HrcJ 24 HrcJ 24 HrcJ 24 BsaJ 13 FliF 26 -
IM ring Major IM ring component SctD 10 EscD - B7UM96 PscD 11 YscD MxiG PrgH SsaD CdsD 14, 15 BscD 20 HrpQ HrcD, HrpW HrcD 24 BsaM 13 FliG 12 -
Export apparatus or Translocase Translocase channel SctR 10 EscR - B7UMC1 PscR 11 YscR Spa24 InvL/SpaP SsaR CdsR 15 BscR 20 HrcR 24 HrcR 24 HrcR 24 BsaW 13 FliP 26 -
Export apparatus or Translocase Translocase channel SctS 10 EscS - B7UMC0 PscS 11 YscS Spa9 SpaQ SsaS CdsS 15 BscS 20 HrcS 24 HrcS 24 HrcS 24 BsaX 13 FliQ 26 -
Export apparatus or Translocase Translocase channel SctT 10 EscT - B7UMB9 PscT 11 YscT Spa29 InvN/SpaR SsaT CdsT 15 BscT 20 HrcT 24 HrcT 24 HrcT 24 BsaY 13 FliR 26 -
Export apparatus or Translocase Minor component, external to channel SctU 10 EscU - B7UMB8 PscU 11 YscU Spa40 SpaS SsaU CdsU 15 BscU 20 HrcU 24 HrcU 24 HrcU 24 BsaZ 13 FlhB 26 -
Export apparatus or Translocase Major component, external to channel SctV 10 EscV - B7UMA7 PcrD 11 YscV (LcrD) MxiA InvA SsaV CdsV 15 BscV 20 HrcV HrcV HcrV 24 BsaQ 13 FlhA 26 -
ATPase complex External stator** connecting ATPase and Cytoplasmic ring SctL 10 EscL - B7UMC2 PscL 11 YscL MxiN OrgB 13 SsaK CdsL 14, 15 BscL 20 HrcE HrpF HrcL 24 OrgB 13 FliH 26 F1: δ/F0: b
ATPase complex Hexameric ring-structure ATPase SctN 10 EscN - B7UMA6 PscN 11 YscN Spa47 InvC/SpaL SsaN CdsN 14, 15 BscN 20 HrcN 24 HrcN 24 HrcN 24 BsaS 13 FliI 26 F1: α/F1: β
ATPase complex Central stalk**, inserting in ATPase ring SctO 10 EscO - B7UMA5 PscO 11 YscO Spa13 InvI SsaO CdsO 14, 15 - HrpO HrpD HrpB7 24 HrpD or BsaU 13 FliJ 12 F1: γ
Cytoplasmic ring Component of 6 Pod assembly SctQ 10 SepQ - B7UMA3 PscQ 11 YscQ Spa33 SpaO SsaQ CdsQ 14, 15 BscQ 20 HrcQA+B 24 HrcQ HrcQA+B 24 BsaV 13 FliN/FliM 26 -
Cytoplasmic ring Connector of Pods with SctD SctK 10 EscK - B7UMC3 PscK 11 YscK MxiK OrgA 13 - - - HrpD - - OrgA 13 - -
Gatekeeper Gatekeeper/Affinity switch SctW 10 SepL - B7UM95 PopN 11 YopN +TyeA MxiC InvE SsaL CopN 14, 15 BopN 19 HrpJ HpaA 24 HpaA 24 BsaP 13 - -
Gatekeeper Subunit 1 of SctW chaperone heterodimer - SepD - B7UMB2 - - - - SpiC 18 - - HrpG 28 - - - - -
Gatekeeper Subunit 2 of SctW chaperone heterodimer - CesL - B7UMA8 - - - - - - - HrpV 28 - - - - -
Assembly regulators Molecular ruler regulating needle/filament length SctP 10 EscP - B7UMA4 PscP 11 YscP Spa32 InvJ SsaP CdsP 15 BscK 20 HrpP HpaP HpaC 24 BsaU 13 FliK 26 -
Chaperones For early substrates (needle component) - EscG - B7UM89 PscG 11 YscG 11 - - - - - - - - - - -
Chaperones For early substrates - EscE - B7UMC5 PscE 11 YscE 11 - - - - - - - - - - -
Chaperones For middle substrates (filament component) - CesAB - B7UMC4 - - - - - - Btc22 22 - - - - - -
Chaperones For middle substrates (translocators) - CesD - B7UMB4 PcrH 11 SycD 11 IpgC 11 SicA 16 - - Scc2/Scc3 23 - - - BicA 13 - -
Chaperones For middle substrates (translocators) - CesD2 - B7UM91 - - - - - - - - - - - - -
Chaperones For late substrates (effectors) - CesF - B7UMA1 - - - - - - - - - - - - -
Chaperones For late substrates (effectors) - CesT - P21244 - SycE 12 - SigE 17 - - - - - - - - -
Chaperones For late substrates (effectors) - - - YsaK 12 Spa15 12 InvB 12, 13 - - - - - - InvB 12, 13 - -
Chaperones For flagellar substrate (FlgK) - - - - - - - - - - - - - FlgN -
Chaperones For flagellar substrate (FliC) - - - - - - - - - - - - - FliS -
Chaperones For flagellar substrate (FliD) - - - - - - - - - - - - - FliT -
Transcription regulators Global Regulator - Ler - B7UMC6 - - - - - - - - - - - - -
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