E. coli k12 (O127:H6) Longitudinal Position of proteins

  • This page
Nucleoid Cytoplasmic Peripheral inner membrane protein facing the cytoplasm Integral inner membrane Ribosomal Inner membrane lipoprotein Peripheral inner membrane protein facing the periplasm Periplasmic Peripheral outer membrane protein facing the periplasm Outer membrane β-barrel protein Peripheral outer membrane protein facing the extra-cellular space Extra-cellular Outer membrane lipoprotein

Protein ID /
Accession #
(UniProt)
Gene Name
(UniProt)
Protein Name
(UniProt)
Protein Name
(STEPdb)
Symbol
(STEPdb)
Topology Class
Full name
(STEPdb)
Topology Class
UniProt
Longitudinal positioning
of proteins
Location
notes
Role and/or
mechanism of action
Short protein
description
References Cited in
literature as
LACY_ECOLI
P02920
lacY Lactose permease (Lactose-proton symport) integral IM protein (SEC in IM), Lactose permease LacY B Integral Inner Membrane, cytoplasmic side Cell inner membrane polar - Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Lactose permease PMID: 20008071 LacY
MCP1_ECOLI
P02942
tsr Methyl-accepting chemotaxis protein I (MCP-I) (Serine chemoreceptor protein) integral IM protein (SEC in IM), Methyl-accepting chemotaxis I Tsr B Integral Inner Membrane, cytoplasmic side Cell inner membrane polar - Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids. Methyl-accepting chemotaxis protein I PMID: 20457568 Tsr
FTSQ_ECOLI
P06136
ftsQ Cell division protein FtsQ integral IM protein (SEC in IM), Cell division FtsQ B Integral Inner Membrane, cytoplasmic side Cell inner membrane midcell - Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. Cell division protein FtsQ PMID: 26160297 FtsQ
MCP2_ECOLI
P07017
tar Methyl-accepting chemotaxis protein II (MCP-II) (Aspartate chemoreceptor protein) integral IM protein (SEC in IM), Methyl-accepting chemotaxis II Tar B Integral Inner Membrane, cytoplasmic side Cell inner membrane polar - Tar is the primary receptor for the amino acids aspartate, asparagine and glutamate; in strains lacking the Tsr receptor, Tar can mediate a chemotactic response to serine, cysteine, glycine, alanine and asparagine. Aspartate chemoreceptor Tar PMID: 29463603 Tar
CHEA_ECOLI
P07363
cheA Chemotaxis protein CheA (EC 2.7.13.3) cytoplasmic peripheral IM protein, Chemotaxis CheA A,F1 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm Cytoplasm polar - Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY. Chemotaxis protein CheA PMID: 19965466, PMID: 8456299 CheA
FTSB_ECOLI
P0A6S5
ftsB Cell division protein FtsB integral IM protein (SEC in IM), Cell division FtsB B Integral Inner Membrane, cytoplasmic side Cell inner membrane midcell - Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. Cell division protein FtsB PMID: 26160297 FtsB
MSCL_ECOLI
P0A742
mscL Large-conductance mechanosensitive channel integral IM protein (YidC in IM), Large-conductance mechanosensitive channel MscL B Integral Inner Membrane, cytoplasmic side Cell inner membrane polar sometimes localizes at poles mechanosensitive (MS) channel MscL mediates solute efflux in response to osmotic downshock Large-conductance mechanosensitive channel PMID: 20008071 MscL
TOLB_ECOLI
P0A855
tolB Tol-Pal system protein TolB periplasmic & peripheral OM protein (SEC through IM), Tol-Pal system TolB G,F3 Periplasmic, Peripheral outer membrane protein facing the periplasm Periplasm midcell - The Tol-Pal system plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. It also has a role in facilitating phage infection and colicin uptake. Tol-Pal system protein TolB PMID: 17233825, PMID: 20693330, PMID: 29463603 TolB
PAL_ECOLI
P0A912
pal Peptidoglycan-associated lipoprotein (PAL) (Tol-Pal system lipoprotein Pal) OM lipoprotein (SEC through IM), inserted in OM by LOL), PG-associated Pal I Outer Membrane Lipoprotein Cell outer membrane midcell - The Tol-Pal system plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. It also has a role in facilitating phage infection and colicin uptake. Peptidoglycan-associated outer membrane lipoprotein Pal PMID: 17233825, PMID: 20693330, PMID: 29463603 Pal
CHEW_ECOLI
P0A964
cheW Chemotaxis protein CheW cytoplasmic protein, Chemotaxis CheW A Cytoplasmic Cytoplasm polar - Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to CheY and CheB. Chemotaxis protein CheW PMID: 19965466, PMID: 8456299 CheW
FTSZ_ECOLI
P0A9A6
ftsZ Cell division protein FtsZ cytoplasmic peripheral IM protein, Cell division FtsZ A,F1 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm Cytoplasm midcell - Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. Cell division protein FtsZ PMID: 20457568, PMID: 9864327 FtsZ
CHEZ_ECOLI
P0A9H9
cheZ Protein phosphatase CheZ (EC 3.1.3.-) (Chemotaxis protein CheZ) cytoplasmic peripheral IM protein, phosphatase CheZ A,F1 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm Cytoplasm polar - Cytosolic phosphatase which functions in the chemotaxis signal transduction complex Chemotaxis protein Z PMID: 19542283 CheZ
FTSW_ECOLI
P0ABG4
ftsW Probable peptidoglycan glycosyltransferase FtsW (PGT) (EC 2.4.1.129) (Cell division protein FtsW) (Cell wall polymerase) (Lipid II flippase FtsW) (Peptidoglycan polymerase) (PG polymerase) integral IM protein (SEC in IM), Probable PG glycosyltransferase FtsW B Integral Inner Membrane, cytoplasmic side Cell inner membrane midcell - Peptidoglycan polymerase that is essential for cell division (Probable). Required for localization of FtsI. Probable peptidoglycan glycosyltransferase FtsW PMID: 9603865 FtsW
FTSA_ECOLI
P0ABH0
ftsA Cell division protein FtsA cytoplasmic peripheral IM protein, Cell division FtsA A,F1 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm Cell inner membrane midcell - Essential cell division protein that assists in the assembly of the Z ring Cell division protein FtsA PMID: 20457568, PMID: 9864327 FtsA
TOLQ_ECOLI
P0ABU9
tolQ Tol-Pal system protein TolQ integral IM protein (SEC in IM), Tol-Pal system TolQ B Integral Inner Membrane, cytoplasmic side Cell inner membrane midcell - The Tol-Pal system plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. It also has a role in facilitating phage infection and colicin uptake. Tol-Pal system protein TolQ PMID: 17233825, PMID: 20693330, PMID: 29463603 TolQ
TOLR_ECOLI
P0ABV6
tolR Tol-Pal system protein TolR integral IM protein (SEC in IM), Tol-Pal system TolR B Integral Inner Membrane, cytoplasmic side Cell inner membrane midcell - The Tol-Pal system plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. It also has a role in facilitating phage infection and colicin uptake. Tol-Pal system protein TolR PMID: 17233825, PMID: 20693330, PMID: 29463603 TolR
FTSI_ECOLI
P0AD68
ftsI Peptidoglycan D,D-transpeptidase FtsI (EC 3.4.16.4) (Essential cell division protein FtsI) (Murein transpeptidase) (Penicillin-binding protein 3) (PBP-3) (Peptidoglycan synthase FtsI) integral IM protein (SEC in IM), PG D,D-transpeptidase FtsI B Integral Inner Membrane, cytoplasmic side Cell inner membrane midcell - Essential cell division protein that catalyzes cross-linking of the peptidoglycan cell wall at the division septum Peptidoglycan D,D-transpeptidase FtsI PMID: 20457568, PMID: 9864327 FtsI
NLPD_ECOLI
P0ADA3
nlpD Murein hydrolase activator NlpD OM lipoprotein (SEC through IM), inserted in OM by LOL), Murein hydrolase activator NlpD I Outer Membrane Lipoprotein Cell inner membrane midcell - absolutely required for septal PG splitting and daughter cell separation LytM (lysostaphin)-domain containing factor NlpD PMID: 19525345 NlpD
ZAPA_ECOLI
P0ADS2
zapA Cell division protein ZapA (Z ring-associated protein ZapA) cytoplasmic peripheral IM protein, Cell division ZapA A,F1 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm Cytoplasm midcell - Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. Cell division protein ZapA PMID: 20452938 ZapA
DCUS_ECOLI
P0AEC8
dcuS Sensor histidine kinase DcuS (EC 2.7.13.3) (Fumarate sensor) integral IM protein (SEC-YidC in IM), Sensor histidine kinase DcuS B Integral Inner Membrane, cytoplasmic side Cell inner membrane, Multi-pass membrane protein polar - Sensory histidine kinase of the DcuSR two component system which controls the expression of genes relating to the catabolism of exogenous C4 dicarboxylates Sensory histidine kinase DcuS PMID: 18667579 DcuS
Records 1 to 20 of 35