Homologous proteins of type three secretion system (T3SS) in pathogens and the flagellum
| T3SS in pathogenic bacteria | Flagellar T3SS | |||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mammalian pathogensss | Plant pathogens | |||||||||||||||
| Structural sub assembly of injectisome | Subunit function/role | Common name | EPEC | P. aeruginosa T3SS | Yersinia T3SS | Shigella flexneri | Salmonella sp. SPI 1 | Salmonella enterica SPI 2 | Chlamydia pneumoniae | Bordetella | P. syringae | R. solanacearum | Xanthomonas spp. | B. pseudomallei T3SS3 | Yersinia Pestis |
F1F0 ATPase |
| Translocators | Translocon pore protein | SctE 10 | EspD - B7UM93 | PopB 11 | YopB | IpaB | SipB | SseC | CopB1/2 14, 15 | BopB 19 | HrpK 24 | PopF1/PopF2 | HrpK 24 | BipB 13 | - | - |
| Translocators | Translocon pore protein | SctB 10 | EspB - Q05129 | PopD 11 | YopD | IpaC | SipC | SseD | CopD1/2 15 | BopD 19 | - | XopA 24 | XopA 24 | BipC 13 | - | - |
| Translocators | Tip/filament protein | SctA 10 | EspA - B7UM94 | PcrV 11 | LcrV | IpaD | SipD | SseD | CT584 or LcrV 14, 15 | Bsp22 21 | - | - | - | BipD 13 | FliC 25 | - |
| Needle | Needle component | SctF 10 | EscF - B7UM90 | PscF 11 | YscF | MxiH | PrgI | SsaG | CdsF 14, 15 | BscF 20 | HrpA | HrpY | HrpE 24 | BsaL 13 | - | - |
| OM ring | Secretin | SctC 10 | EscC - B7UMB3 | PscC 11 | YscC | MxiD | InvG | SsaC | CdsC 14, 15 | BscC 20 | HrcC 24 | HrcC 24 | HrcC 24 | BsaO 13 | FlgI/FlgH * 26 | - |
| - | Pilotin | - | - | ExsB 11 | VirG | MxiM | InvH | - | - | BscW 20 | - | - | - | - | - | - |
| OM-IM connector | Inner rod | SctI 10 | EscI - B7UMB0 | PscI 11 | YscI | MxiI | PrgJ | SsaI | - | BscI 20 | HrpB | HrpJ | HrpB2 24 | BsaK 13 | FlgB/FlgC/FlgF/FlgG 27 | - |
| Accessory enzyme | Muramidase | - | EtgA - B7UMB7 | - | YsaH 13 | IpgF 13 | IagB 13 | IagB 13 | - | - | HrpH | - | - | BapC 13 | - | - |
| IM ring | Lipoprotein ring component | SctJ 10 | EscJ - B7UMB1 | PscJ 11 | YscJ | MxiJ | PrgK | SsaJ | CdsJ 15 | BscJ 20 | HrcJ 24 | HrcJ 24 | HrcJ 24 | BsaJ 13 | FliF 26 | - |
| IM ring | Major IM ring component | SctD 10 | EscD - B7UM96 | PscD 11 | YscD | MxiG | PrgH | SsaD | CdsD 14, 15 | BscD 20 | HrpQ | HrcD, HrpW | HrcD 24 | BsaM 13 | FliG 12 | - |
| Export apparatus or Translocase | Translocase channel | SctR 10 | EscR - B7UMC1 | PscR 11 | YscR | Spa24 | InvL/SpaP | SsaR | CdsR 15 | BscR 20 | HrcR 24 | HrcR 24 | HrcR 24 | BsaW 13 | FliP 26 | - |
| Export apparatus or Translocase | Translocase channel | SctS 10 | EscS - B7UMC0 | PscS 11 | YscS | Spa9 | SpaQ | SsaS | CdsS 15 | BscS 20 | HrcS 24 | HrcS 24 | HrcS 24 | BsaX 13 | FliQ 26 | - |
| Export apparatus or Translocase | Translocase channel | SctT 10 | EscT - B7UMB9 | PscT 11 | YscT | Spa29 | InvN/SpaR | SsaT | CdsT 15 | BscT 20 | HrcT 24 | HrcT 24 | HrcT 24 | BsaY 13 | FliR 26 | - |
| Export apparatus or Translocase | Minor component, external to channel | SctU 10 | EscU - B7UMB8 | PscU 11 | YscU | Spa40 | SpaS | SsaU | CdsU 15 | BscU 20 | HrcU 24 | HrcU 24 | HrcU 24 | BsaZ 13 | FlhB 26 | - |
| Export apparatus or Translocase | Major component, external to channel | SctV 10 | EscV - B7UMA7 | PcrD 11 | YscV (LcrD) | MxiA | InvA | SsaV | CdsV 15 | BscV 20 | HrcV | HrcV | HcrV 24 | BsaQ 13 | FlhA 26 | - |
| ATPase complex | External stator** connecting ATPase and Cytoplasmic ring | SctL 10 | EscL - B7UMC2 | PscL 11 | YscL | MxiN | OrgB 13 | SsaK | CdsL 14, 15 | BscL 20 | HrcE | HrpF | HrcL 24 | OrgB 13 | FliH 26 | F1: δ/F0: b |
| ATPase complex | Hexameric ring-structure ATPase | SctN 10 | EscN - B7UMA6 | PscN 11 | YscN | Spa47 | InvC/SpaL | SsaN | CdsN 14, 15 | BscN 20 | HrcN 24 | HrcN 24 | HrcN 24 | BsaS 13 | FliI 26 | F1: α/F1: β |
| ATPase complex | Central stalk**, inserting in ATPase ring | SctO 10 | EscO - B7UMA5 | PscO 11 | YscO | Spa13 | InvI | SsaO | CdsO 14, 15 | - | HrpO | HrpD | HrpB7 24 | HrpD or BsaU 13 | FliJ 12 | F1: γ |
| Cytoplasmic ring | Component of 6 Pod assembly | SctQ 10 | SepQ - B7UMA3 | PscQ 11 | YscQ | Spa33 | SpaO | SsaQ | CdsQ 14, 15 | BscQ 20 | HrcQA+B 24 | HrcQ | HrcQA+B 24 | BsaV 13 | FliN/FliM 26 | - |
| Cytoplasmic ring | Connector of Pods with SctD | SctK 10 | EscK - B7UMC3 | PscK 11 | YscK | MxiK | OrgA 13 | - | - | - | HrpD | - | - | OrgA 13 | - | - |
| Gatekeeper | Gatekeeper/Affinity switch | SctW 10 | SepL - B7UM95 | PopN 11 | YopN +TyeA | MxiC | InvE | SsaL | CopN 14, 15 | BopN 19 | HrpJ | HpaA 24 | HpaA 24 | BsaP 13 | - | - |
| Gatekeeper | Subunit 1 of SctW chaperone heterodimer | - | SepD - B7UMB2 | - | - | - | - | SpiC 18 | - | - | HrpG 28 | - | - | - | - | - |
| Gatekeeper | Subunit 2 of SctW chaperone heterodimer | - | CesL - B7UMA8 | - | - | - | - | - | - | - | HrpV 28 | - | - | - | - | - |
| Assembly regulators | Molecular ruler regulating needle/filament length | SctP 10 | EscP - B7UMA4 | PscP 11 | YscP | Spa32 | InvJ | SsaP | CdsP 15 | BscK 20 | HrpP | HpaP | HpaC 24 | BsaU 13 | FliK 26 | - |
| Chaperones | For early substrates (needle component) | - | EscG - B7UM89 | PscG 11 | YscG 11 | - | - | - | - | - | - | - | - | - | - | - |
| Chaperones | For early substrates | - | EscE - B7UMC5 | PscE 11 | YscE 11 | - | - | - | - | - | - | - | - | - | - | - |
| Chaperones | For middle substrates (filament component) | - | CesAB - B7UMC4 | - | - | - | - | - | - | Btc22 22 | - | - | - | - | - | - |
| Chaperones | For middle substrates (translocators) | - | CesD - B7UMB4 | PcrH 11 | SycD 11 | IpgC 11 | SicA 16 | - | - | Scc2/Scc3 23 | - | - | - | BicA 13 | - | - |
| Chaperones | For middle substrates (translocators) | - | CesD2 - B7UM91 | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Chaperones | For late substrates (effectors) | - | CesF - B7UMA1 | - | - | - | - | - | - | - | - | - | - | - | - | - |
| Chaperones | For late substrates (effectors) | - | CesT - P21244 | - | SycE 12 | - | SigE 17 | - | - | - | - | - | - | - | - | - |
| Chaperones | For late substrates (effectors) | - | - | - | YsaK 12 | Spa15 12 | InvB 12, 13 | - | - | - | - | - | - | InvB 12, 13 | - | - |
| Chaperones | For flagellar substrate (FlgK) | - | - | - | - | - | - | - | - | - | - | - | - | - | FlgN | - |
| Chaperones | For flagellar substrate (FliC) | - | - | - | - | - | - | - | - | - | - | - | - | - | FliS | - |
| Chaperones | For flagellar substrate (FliD) | - | - | - | - | - | - | - | - | - | - | - | - | - | FliT | - |
| Transcription regulators | Global Regulator | - | Ler - B7UMC6 | - | - | - | - | - | - | - | - | - | - | - | - | - |
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