E. coli k12 (O127:H6) Longitudinal Position of proteins

Protein ID / Accession # (UniProt)	Gene Name (UniProt)	Protein Name (UniProt)	Protein Name (STEPdb)	Symbol (STEPdb)	Topology Class Full name (STEPdb)	Topology Class UniProt	Longitudinal positioning of proteins	Location notes	Role and/or mechanism of action	Short protein description	References	Cited in literature as
	Search.. Close amiB aqpZ cheA cheW cheZ dcuS dpiB envC ftsA ftsB ftsI ftsK ftsL ftsN ftsQ ftsW ftsZ lacY mepM mscL mscS murG nlpD pal proP proW slmA tar tolA tolB tolQ tolR tsr zapA zipA	Search.. Close Aquaporin Z (Bacterial nodulin-like intrinsic protein) Cell division protein FtsA Cell division protein FtsB Cell division protein FtsL Cell division protein FtsN Cell division protein FtsQ Cell division protein FtsZ Cell division protein ZapA (Z ring-associated protein ZapA) Cell division protein ZipA (FtsZ interacting protein A) Chemotaxis protein CheA (EC 2.7.13.3) Chemotaxis protein CheW DNA translocase FtsK Glycine betaine/proline betaine transport system permease protein ProW Lactose permease (Lactose-proton symport) Large-conductance mechanosensitive channel Methyl-accepting chemotaxis protein I (MCP-I) (Serine chemoreceptor protein) Methyl-accepting chemotaxis protein II (MCP-II) (Aspartate chemoreceptor protein) Murein DD-endopeptidase MepM (EC 3.4.24.-) (Murein hydrolase MepM) (ORFU) Murein hydrolase activator EnvC (Septal ring factor) Murein hydrolase activator NlpD N-acetylmuramoyl-L-alanine amidase AmiB (EC 3.5.1.28) Nucleoid occlusion factor SlmA (Protein Ttk) (Synthetically lethal with a defective Min system protein A) Peptidoglycan-associated lipoprotein (PAL) (Tol-Pal system lipoprotein Pal) Peptidoglycan D,D-transpeptidase FtsI (EC 3.4.16.4) (Essential cell division protein FtsI) (Murein transpeptidase) (Penicillin-binding protein 3) (PBP-3) (Peptidoglycan synthase FtsI) Probable peptidoglycan glycosyltransferase FtsW (PGT) (EC 2.4.1.129) (Cell division protein FtsW) (Cell wall polymerase) (Lipid II flippase FtsW) (Peptidoglycan polymerase) (PG polymerase) Proline/betaine transporter (Proline porter II) (PPII) Protein phosphatase CheZ (EC 3.1.3.-) (Chemotaxis protein CheZ) Sensor histidine kinase DcuS (EC 2.7.13.3) (Fumarate sensor) Sensor histidine kinase DpiB (EC 2.7.13.3) (Sensor histidine kinase CitA) Small-conductance mechanosensitive channel Tol-Pal system protein TolA Tol-Pal system protein TolB Tol-Pal system protein TolQ Tol-Pal system protein TolR UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase (EC 2.4.1.227) (Undecaprenyl-PP-MurNAc-pentapeptide-UDPGlcNAc GlcNAc transferase)	Search.. Close cytoplasmic peripheral IM protein, Cell division FtsA cytoplasmic peripheral IM protein, Cell division FtsZ cytoplasmic peripheral IM protein, Cell division ZapA cytoplasmic peripheral IM protein, Chemotaxis CheA cytoplasmic peripheral IM protein, phosphatase CheZ cytoplasmic peripheral IM protein, UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase MurG cytoplasmic protein, Chemotaxis CheW IM lipoprotein (SEC through IM), Cell division FtsL integral IM protein (SEC-YidC in IM), Aquaporin Z AqpZ integral IM protein (SEC-YidC in IM), Glycine betaine/proline betaine transport system permease ProW integral IM protein (SEC-YidC in IM), Sensor histidine kinase DcuS integral IM protein (SEC-YidC in IM), Sensor histidine kinase DpiB integral IM protein (SEC in IM), Cell division FtsB integral IM protein (SEC in IM), Cell division FtsN integral IM protein (SEC in IM), Cell division FtsQ integral IM protein (SEC in IM), Cell division ZipA integral IM protein (SEC in IM), Lactose permease LacY integral IM protein (SEC in IM), Methyl-accepting chemotaxis I Tsr integral IM protein (SEC in IM), Methyl-accepting chemotaxis II Tar integral IM protein (SEC in IM), Murein DD-endopeptidase MepM MepM integral IM protein (SEC in IM), PG D,D-transpeptidase FtsI integral IM protein (SEC in IM), Probable PG glycosyltransferase FtsW integral IM protein (SEC in IM), Proline/betaine transporter ProP integral IM protein (SEC in IM), Small-conductance mechanosensitive channel MscS integral IM protein (SEC in IM), Tol-Pal system TolA integral IM protein (SEC in IM), Tol-Pal system TolQ integral IM protein (SEC in IM), Tol-Pal system TolR integral IM protein (YidC in IM), Large-conductance mechanosensitive channel MscL nucleoid & integral IM protein (SEC in IM), DNA translocase FtsK nucleoid protein, Nucleoid occlusion factor SlmA OM lipoprotein (SEC through IM), inserted in OM by LOL), Murein hydrolase activator NlpD OM lipoprotein (SEC through IM), inserted in OM by LOL), PG-associated Pal periplasmic & peripheral OM protein (SEC through IM), Tol-Pal system TolB periplasmic protein (SEC through IM), Murein hydrolase activator EnvC periplasmic protein (SEC through IM), N-acetylmuramoyl-L-alanine amidase AmiB	Search.. Close A A,F1 A,N B B,N E G G,F3 I	Search.. Close Cytoplasmic Cytoplasmic, Nucleoid Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm Inner Membrane Lipoprotein Integral Inner Membrane, cytoplasmic side Integral Inner Membrane, Nucleoid Outer Membrane Lipoprotein Periplasmic Periplasmic, Peripheral outer membrane protein facing the periplasm	Search.. Close Cell inner membrane Cell outer membrane Cytoplasm Multi-pass membrane protein nucleoid Periplasm	Search.. Close midcell polar	Search.. Close binds to the nucleoid and interacts with FtsZ localizes to the Z ring in an FtsZ-dependent manner partial enrichment at cell poles sometimes localizes at poles None	Search.. Close absolutely required for septal PG splitting and daughter cell separation Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring. Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response to abrupt changes in osmolarity. Cytosolic phosphatase which functions in the chemotaxis signal transduction complex Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. Essential cell division protein that assists in the assembly of the Z ring Essential cell division protein that catalyzes cross-linking of the peptidoglycan cell wall at the division septum Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY. Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to CheY and CheB. mechanosensitive (MS) channel MscL mediates solute efflux in response to osmotic downshock mechanosensitive (MS) channel MscS mediates solute efflux in response to osmotic downshock Membrane associated sensor kinase component of the DpiAB two component system which regulates the expression of genes involved in anaerobic citrate fermentation Part of the ProU ABC transporter complex involved in glycine betaine and proline betaine uptake Peptidoglycan polymerase that is essential for cell division (Probable). Required for localization of FtsI. play the predominant role in cell separation Proton symporter that senses osmotic shifts and responds by importing osmolytes such as proline, glycine betaine, stachydrine, pipecolic acid, ectoine and taurine. It is both an osmosensor and an osmoregulator which is available to participate early in the bacterial osmoregulatory response Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids. Required for nucleoid occlusion (NO) phenomenon, which prevents Z-ring formation and cell division over the nucleoid. Acts as a DNA-associated cell division inhibitor that binds simultaneously chromosomal DNA and FtsZ, and disrupts the assembly of FtsZ polymers. Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system). Sensory histidine kinase of the DcuSR two component system which controls the expression of genes relating to the catabolism of exogenous C4 dicarboxylates Tar is the primary receptor for the amino acids aspartate, asparagine and glutamate; in strains lacking the Tsr receptor, Tar can mediate a chemotactic response to serine, cysteine, glycine, alanine and asparagine. The Tol-Pal system plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. It also has a role in facilitating phage infection and colicin uptake. This protein is involved in the pathway cell wall polysaccharide biosynthesis, which is part of Cell wall biogenesis. This protein is involved in the pathway cell wall polysaccharide biosynthesis, which is part of Cell wall biogenesis. Its role is probably to cleave D-Ala-mDAP cross-links to allow insertion of new glycans and thus cell wall expansion.	Search.. Close Aquaporin Z Aspartate chemoreceptor Tar Cell division protein FtsA Cell division protein FtsB Cell division protein FtsL Cell division protein FtsN Cell division protein FtsQ Cell division protein FtsZ Cell division protein ZapA Cell division protein ZipA Chemotaxis protein CheA Chemotaxis protein CheW Chemotaxis protein Z DNA translocase FtsK glycine betaine ABC transporter membrane subunit ProW Lactose permease Large-conductance mechanosensitive channel LytC-type N-acetylmuramyl-L-alanine amidase AmiB LytM (lysostaphin)-domain containing factor EnvC LytM (lysostaphin)-domain containing factor NlpD Methyl-accepting chemotaxis protein I Murein DD-endopeptidase MepM N-acetylglucosaminyl transferase Nucleoid occlusion factor SlmA Peptidoglycan-associated outer membrane lipoprotein Pal Peptidoglycan D,D-transpeptidase FtsI Probable peptidoglycan glycosyltransferase FtsW Proline/betaine transporter Sensory histidine kinase DcuS Sensory histidine kinase DpiB Small-conductance mechanosensitive channel Tol-Pal system protein TolA Tol-Pal system protein TolB Tol-Pal system protein TolQ Tol-Pal system protein TolR	Search.. Close 17233825 17233825 17233825 17233825 17233825 18667579 18667579 18667579 18667579 18667579 19525345 19525345 19525345 19525345 19525345 19542283 19542283 19542283 19542283 19542283 19965466 19965466 19965466 19965466 19965466 20008071 20008071 20008071 20008071 20008071 20452938 20452938 20452938 20452938 20452938 20457568 20457568 20457568 20457568 20457568 20693330 20693330 20693330 20693330 20693330 24345373 24345373 24345373 24345373 24345373 26160297 26160297 26160297 26160297 26160297 29463603 29463603 29463603 29463603 29463603 8456299 8456299 8456299 8456299 8456299 9603865 9603865 9603865 9603865 9603865 9864327 9864327 9864327 9864327 9864327	Search.. Close AmiB AqpZ CheA CheW CheZ DcuS DpiB (CitA) EnvC FtsA FtsB FtsI FtsK FtsL FtsN FtsQ FtsW FtsZ LacY MscL MscS Murein, YebA MurG NlpD Pal ProP ProW SlmA Tar TolA TolB TolQ TolR Tsr ZapA ZipA
LACY_ECOLI P02920	lacY	Lactose permease (Lactose-proton symport)	integral IM protein (SEC in IM), Lactose permease LacY	B	Integral Inner Membrane, cytoplasmic side	Cell inner membrane	polar	-	Responsible for transport of beta-galactosides into the cell, with the concomitant import of a proton (symport system).	Lactose permease	PMID: 20008071	LacY
MCP1_ECOLI P02942	tsr	Methyl-accepting chemotaxis protein I (MCP-I) (Serine chemoreceptor protein)	integral IM protein (SEC in IM), Methyl-accepting chemotaxis I Tsr	B	Integral Inner Membrane, cytoplasmic side	Cell inner membrane	polar	-	Receptor for the attractant L-serine and related amino acids. Is also responsible for chemotaxis away from a wide range of repellents, including leucine, indole, and weak acids.	Methyl-accepting chemotaxis protein I	PMID: 20457568	Tsr
FTSQ_ECOLI P06136	ftsQ	Cell division protein FtsQ	integral IM protein (SEC in IM), Cell division FtsQ	B	Integral Inner Membrane, cytoplasmic side	Cell inner membrane	midcell	-	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.	Cell division protein FtsQ	PMID: 26160297	FtsQ
MCP2_ECOLI P07017	tar	Methyl-accepting chemotaxis protein II (MCP-II) (Aspartate chemoreceptor protein)	integral IM protein (SEC in IM), Methyl-accepting chemotaxis II Tar	B	Integral Inner Membrane, cytoplasmic side	Cell inner membrane	polar	-	Tar is the primary receptor for the amino acids aspartate, asparagine and glutamate; in strains lacking the Tsr receptor, Tar can mediate a chemotactic response to serine, cysteine, glycine, alanine and asparagine.	Aspartate chemoreceptor Tar	PMID: 29463603	Tar
CHEA_ECOLI P07363	cheA	Chemotaxis protein CheA (EC 2.7.13.3)	cytoplasmic peripheral IM protein, Chemotaxis CheA	A,F1	Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm	Cytoplasm	polar	-	Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. CheA is autophosphorylated; it can transfer its phosphate group to either CheB or CheY.	Chemotaxis protein CheA	PMID: 19965466, PMID: 8456299	CheA
FTSB_ECOLI P0A6S5	ftsB	Cell division protein FtsB	integral IM protein (SEC in IM), Cell division FtsB	B	Integral Inner Membrane, cytoplasmic side	Cell inner membrane	midcell	-	Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic.	Cell division protein FtsB	PMID: 26160297	FtsB
MSCL_ECOLI P0A742	mscL	Large-conductance mechanosensitive channel	integral IM protein (YidC in IM), Large-conductance mechanosensitive channel MscL	B	Integral Inner Membrane, cytoplasmic side	Cell inner membrane	polar	sometimes localizes at poles	mechanosensitive (MS) channel MscL mediates solute efflux in response to osmotic downshock	Large-conductance mechanosensitive channel	PMID: 20008071	MscL
TOLB_ECOLI P0A855	tolB	Tol-Pal system protein TolB	periplasmic & peripheral OM protein (SEC through IM), Tol-Pal system TolB	G,F3	Periplasmic, Peripheral outer membrane protein facing the periplasm	Periplasm	midcell	-	The Tol-Pal system plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. It also has a role in facilitating phage infection and colicin uptake.	Tol-Pal system protein TolB	PMID: 17233825, PMID: 20693330, PMID: 29463603	TolB
PAL_ECOLI P0A912	pal	Peptidoglycan-associated lipoprotein (PAL) (Tol-Pal system lipoprotein Pal)	OM lipoprotein (SEC through IM), inserted in OM by LOL), PG-associated Pal	I	Outer Membrane Lipoprotein	Cell outer membrane	midcell	-	The Tol-Pal system plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. It also has a role in facilitating phage infection and colicin uptake.	Peptidoglycan-associated outer membrane lipoprotein Pal	PMID: 17233825, PMID: 20693330, PMID: 29463603	Pal
CHEW_ECOLI P0A964	cheW	Chemotaxis protein CheW	cytoplasmic protein, Chemotaxis CheW	A	Cytoplasmic	Cytoplasm	polar	-	Involved in the transmission of sensory signals from the chemoreceptors to the flagellar motors. It physically bridges CheA to the MCPs (methyl-accepting chemotaxis proteins) to allow regulated phosphotransfer to CheY and CheB.	Chemotaxis protein CheW	PMID: 19965466, PMID: 8456299	CheW
FTSZ_ECOLI P0A9A6	ftsZ	Cell division protein FtsZ	cytoplasmic peripheral IM protein, Cell division FtsZ	A,F1	Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm	Cytoplasm	midcell	-	Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site.	Cell division protein FtsZ	PMID: 20457568, PMID: 9864327	FtsZ
CHEZ_ECOLI P0A9H9	cheZ	Protein phosphatase CheZ (EC 3.1.3.-) (Chemotaxis protein CheZ)	cytoplasmic peripheral IM protein, phosphatase CheZ	A,F1	Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm	Cytoplasm	polar	-	Cytosolic phosphatase which functions in the chemotaxis signal transduction complex	Chemotaxis protein Z	PMID: 19542283	CheZ
FTSW_ECOLI P0ABG4	ftsW	Probable peptidoglycan glycosyltransferase FtsW (PGT) (EC 2.4.1.129) (Cell division protein FtsW) (Cell wall polymerase) (Lipid II flippase FtsW) (Peptidoglycan polymerase) (PG polymerase)	integral IM protein (SEC in IM), Probable PG glycosyltransferase FtsW	B	Integral Inner Membrane, cytoplasmic side	Cell inner membrane	midcell	-	Peptidoglycan polymerase that is essential for cell division (Probable). Required for localization of FtsI.	Probable peptidoglycan glycosyltransferase FtsW	PMID: 9603865	FtsW
FTSA_ECOLI P0ABH0	ftsA	Cell division protein FtsA	cytoplasmic peripheral IM protein, Cell division FtsA	A,F1	Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm	Cell inner membrane	midcell	-	Essential cell division protein that assists in the assembly of the Z ring	Cell division protein FtsA	PMID: 20457568, PMID: 9864327	FtsA
TOLQ_ECOLI P0ABU9	tolQ	Tol-Pal system protein TolQ	integral IM protein (SEC in IM), Tol-Pal system TolQ	B	Integral Inner Membrane, cytoplasmic side	Cell inner membrane	midcell	-	The Tol-Pal system plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. It also has a role in facilitating phage infection and colicin uptake.	Tol-Pal system protein TolQ	PMID: 17233825, PMID: 20693330, PMID: 29463603	TolQ
TOLR_ECOLI P0ABV6	tolR	Tol-Pal system protein TolR	integral IM protein (SEC in IM), Tol-Pal system TolR	B	Integral Inner Membrane, cytoplasmic side	Cell inner membrane	midcell	-	The Tol-Pal system plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. It also has a role in facilitating phage infection and colicin uptake.	Tol-Pal system protein TolR	PMID: 17233825, PMID: 20693330, PMID: 29463603	TolR
FTSI_ECOLI P0AD68	ftsI	Peptidoglycan D,D-transpeptidase FtsI (EC 3.4.16.4) (Essential cell division protein FtsI) (Murein transpeptidase) (Penicillin-binding protein 3) (PBP-3) (Peptidoglycan synthase FtsI)	integral IM protein (SEC in IM), PG D,D-transpeptidase FtsI	B	Integral Inner Membrane, cytoplasmic side	Cell inner membrane	midcell	-	Essential cell division protein that catalyzes cross-linking of the peptidoglycan cell wall at the division septum	Peptidoglycan D,D-transpeptidase FtsI	PMID: 20457568, PMID: 9864327	FtsI
NLPD_ECOLI P0ADA3	nlpD	Murein hydrolase activator NlpD	OM lipoprotein (SEC through IM), inserted in OM by LOL), Murein hydrolase activator NlpD	I	Outer Membrane Lipoprotein	Cell inner membrane	midcell	-	absolutely required for septal PG splitting and daughter cell separation	LytM (lysostaphin)-domain containing factor NlpD	PMID: 19525345	NlpD
ZAPA_ECOLI P0ADS2	zapA	Cell division protein ZapA (Z ring-associated protein ZapA)	cytoplasmic peripheral IM protein, Cell division ZapA	A,F1	Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm	Cytoplasm	midcell	-	Activator of cell division through the inhibition of FtsZ GTPase activity, therefore promoting FtsZ assembly into bundles of protofilaments necessary for the formation of the division Z ring.	Cell division protein ZapA	PMID: 20452938	ZapA
DCUS_ECOLI P0AEC8	dcuS	Sensor histidine kinase DcuS (EC 2.7.13.3) (Fumarate sensor)	integral IM protein (SEC-YidC in IM), Sensor histidine kinase DcuS	B	Integral Inner Membrane, cytoplasmic side	Cell inner membrane, Multi-pass membrane protein	polar	-	Sensory histidine kinase of the DcuSR two component system which controls the expression of genes relating to the catabolism of exogenous C4 dicarboxylates	Sensory histidine kinase DcuS	PMID: 18667579	DcuS
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