Proteaseome of E.coli K-12 (MG1655)
| Protein ID / Accession # (UniProt) |
Gene Name (UniProt) |
Protein Name (UniProt) |
Protein Name (STEPdb) |
Symbol (STEPdb) |
Topology Class Full name (STEPdb) |
Co-factors | Type of activity | ATP-requirement | References |
|---|---|---|---|---|---|---|---|---|---|
| LEP_ECOLI P00803 |
lepB | Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I) | integral IM protein (SEC-YidC in IM), Signal peptidase I LepB | B | Integral Inner Membrane, cytoplasmic side | - | Serine-type endopeptidase | - | Karla 2005; Kim 2004; Stein 2000; Sung 1992; Zwizinski 1980 |
| LSPA_ECOLI P00804 |
lspA | Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II) | integral IM protein (SEC in IM), Signal peptidase II LspA | B | Integral Inner Membrane, cytoplasmic side | - | Aspartic-type endopeptidase | - | Innis 1984; Inukai 1984; Tokunaga 1984; Tokunaga 1985; Yu 1984 |
| PBPA_ECOLI P02918 |
mrcA | Penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)] | integral IM protein (SEC in IM), Penicillin-binding 1A MrcA | B | Integral Inner Membrane, cytoplasmic side | - | Serine-type peptidase | - | Born 2006; Egan 2015; Ishino 1980 |
| PBPB_ECOLI P02919 |
mrcB | Penicillin-binding protein 1B (PBP-1b) (PBP1b) (Murein polymerase) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase) (Peptidoglycan glycosyltransferase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)] | integral IM protein (SEC in IM), Penicillin-binding 1B MrcB | B | Integral Inner Membrane, cytoplasmic side | - | Serine-type peptidase | - | Egan 2015; Nakagawa 1984; Schwartz 2001 |
| AMPN_ECOLI P04825 |
pepN | Aminopeptidase N (EC 3.4.11.2) (Alpha-aminoacylpeptide hydrolase) | cytoplasmic peripheral IM protein, Aminopeptidase PepN | A,F1 | Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm | - | Metallopeptidase | - | Addlagatta 2008; Fournie-Zaluski 2009; Ito 2006 |
| PTRA_ECOLI P05458 |
ptrA | Protease 3 (EC 3.4.24.55) (Pitrilysin) (Protease III) (Protease pi) | periplasmic protein (SEC through IM), Protease 3 PtrA | G | Periplasmic | - | Metallopeptidase | - | Cheng 1979; Ding 1992; Han 2014; Lopez-Campistrous 2005 |
| SPPA_ECOLI P08395 |
sppA | Protease 4 (EC 3.4.21.-) (Endopeptidase IV) (Protease IV) (Signal peptide peptidase) | integral IM protein (SEC in IM), Protease 4 SppA | B | Integral Inner Membrane, cytoplasmic side | - | Serine-type peptidase | - | Ichihara 1986; Kim 2008; Saito 2011; Wang 2008 |
| DACC_ECOLI P08506 |
dacC | D-alanyl-D-alanine carboxypeptidase DacC (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (Penicillin-binding protein 6) (PBP-6) | periplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine carboxypeptidase DacC | F2 | Peripheral inner membrane protein facing the periplasm | - | Serine-type peptidase | - | Amanuma 1980; Amanuma 1984 |
| OMPT_ECOLI P09169 |
ompT | Protease 7 (EC 3.4.23.49) (Omptin) (Outer membrane protein 3B) (Protease A) (Protease VII) | OM b-barrel protein (SEC through IM, inserted in OM by BAM), Protease 7 OmpT | H | Outer Membrane b-barrel protein | - | Serine-type peptidase | - | Stumpe 1998 |
| GLPG_ECOLI P09391 |
glpG | Rhomboid protease GlpG (EC 3.4.21.105) (Intramembrane serine protease) | integral IM protein (SEC in IM), Rhomboid protease GlpG | B | Integral Inner Membrane, cytoplasmic side | - | Serine-type peptidase | - | Maegawa 2005; Wu 2006 |
| CLPP_ECOLI P0A6G7 |
clpP | ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Caseinolytic protease) (Endopeptidase Clp) (Heat shock protein F21.5) (Protease Ti) | cytoplasmic protein, ATP-dependent Clp protease proteolytic subunit ClpP | A | Cytoplasmic | ClpA, ClpX | Serine-type peptidase | Yes | Flynn 2004; Kenniston 2003 |
| HSLV_ECOLI P0A7B8 |
hslV | ATP-dependent protease subunit HslV (EC 3.4.25.2) (Heat shock protein HslV) | cytoplasmic protein, ATP-dependent protease subunit HslV | A | Cytoplasmic | HslU | Threonine-type endopeptidase | Yes | Burton 2005; Rohrwild 1996; Seol 1997; Yoo 1996 |
| PEPE_ECOLI P0A7C6 |
pepE | Peptidase E (EC 3.4.13.21) (Alpha-aspartyl dipeptidase) (Asp-specific dipeptidase) (Dipeptidase E) | cytoplasmic protein, Peptidase E PepE | A | Cytoplasmic | - | Serine-type dipeptidase | - | Zhang 1998 |
| LON_ECOLI P0A9M0 |
lon | Lon protease (EC 3.4.21.53) (ATP-dependent protease La) | nucleoid protein, Lon protease Lon | A,N | Cytoplasmic, Nucleoid | - | Serine-type peptidase | Yes | Hansen 2012; Shah 2006; Thomas-Wohlever 2002; Vineyard 2006 |
| FTSH_ECOLI P0AAI3 |
ftsH | ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) (Cell division protease FtsH) | integral IM protein (SEC in IM), ATP-dependent zinc metalloprotease FtsH | B | Integral Inner Membrane, cytoplasmic side | - | Metallopeptidase | Yes | Narberhaus 2009 |
| MRDA_ECOLI P0AD65 |
mrdA | Peptidoglycan D,D-transpeptidase MrdA (EC 3.4.16.4) (Penicillin-binding protein 2) (PBP-2) | integral IM protein (SEC in IM), PG D,D-transpeptidase MrdA | B | Integral Inner Membrane, cytoplasmic side | - | Serine-type peptidase | - | Ishino 1986 |
| FTSI_ECOLI P0AD68 |
ftsI | Peptidoglycan D,D-transpeptidase FtsI (EC 3.4.16.4) (Essential cell division protein FtsI) (Murein transpeptidase) (Penicillin-binding protein 3) (PBP-3) (Peptidoglycan synthase FtsI) | integral IM protein (SEC in IM), PG D,D-transpeptidase FtsI | B | Integral Inner Membrane, cytoplasmic side | - | Serine-type peptidase | - | Botta 1981; Ishino 1981; Nguyen-Disteche 1998; Pisabarro 1986; Spratt 1975 |
| AMPH_ECOLI P0AD70 |
ampH | D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH (EC 3.4.-.-) (DD-alanine-endopeptidase) (DD-carboxypeptidase) (Penicillin-binding protein AmpH) | cytoplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH | A,F1 | Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm | - | Endopeptidase/carboxypeptidase | - | Gonzalez-Leiza 2011 |
| TESA_ECOLI P0ADA1 |
tesA | Thioesterase 1/protease 1/lysophospholipase L1 (TAP) (Acyl-CoA thioesterase 1) (TESA) (EC 3.1.2.2) (Acyl-CoA thioesterase I) (Arylesterase) (EC 3.1.1.2) (Lysophospholipase L1) (EC 3.1.1.5) (Oleoyl-[acyl-carrier-protein] hydrolase) (EC 3.1.2.14) (Phospholipid degradation C) (Pldc) (Protease 1) (EC 3.4.21.-) (Protease I) (Thioesterase I/protease I) (TEP-I) | periplasmic protein (SEC through IM), Thioesterase 1/protease 1/lysophospholipase L1 TesA | G | Periplasmic | - | Peptidase | - | Ichihara 1993; Lee 1997 |
| MAP1_ECOLI P0AE18 |
map | Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M) | cytoplasmic peripheral IM protein, Methionine aminopeptidase Map | A,F1 | Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm | - | Metallopeptidase | - | Ben-Bassat 1987; Xiao 2010 |
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The protease list is available in the downloads section:
Proteaseome .xlsx formrat or Proteaseome .csv format