Proteaseome of E.coli K-12 (MG1655)

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Nucleoid Cytoplasmic Peripheral inner membrane protein facing the cytoplasm Integral inner membrane Ribosomal Inner membrane lipoprotein Peripheral inner membrane protein facing the periplasm Periplasmic Peripheral outer membrane protein facing the periplasm Outer membrane β-barrel protein Peripheral outer membrane protein facing the extra-cellular space Extra-cellular Outer membrane lipoprotein

Protein ID /
Accession #
(UniProt)
Gene Name
(UniProt)
Protein Name
(UniProt)
Protein Name
(STEPdb)
Symbol
(STEPdb)
Topology Class
Full name
(STEPdb)
Co-factors Type of activity ATP-requirement References
LEP_ECOLI
P00803
lepB Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I) integral IM protein (SEC-YidC in IM), Signal peptidase I LepB B Integral Inner Membrane, cytoplasmic side - Serine-type endopeptidase - Karla 2005; Kim 2004; Stein 2000; Sung 1992; Zwizinski 1980
LSPA_ECOLI
P00804
lspA Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II) integral IM protein (SEC in IM), Signal peptidase II LspA B Integral Inner Membrane, cytoplasmic side - Aspartic-type endopeptidase - Innis 1984; Inukai 1984; Tokunaga 1984; Tokunaga 1985; Yu 1984
PBPA_ECOLI
P02918
mrcA Penicillin-binding protein 1A (PBP-1a) (PBP1a) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)] integral IM protein (SEC in IM), Penicillin-binding 1A MrcA B Integral Inner Membrane, cytoplasmic side - Serine-type peptidase - Born 2006; Egan 2015; Ishino 1980
PBPB_ECOLI
P02919
mrcB Penicillin-binding protein 1B (PBP-1b) (PBP1b) (Murein polymerase) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase) (Peptidoglycan glycosyltransferase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)] integral IM protein (SEC in IM), Penicillin-binding 1B MrcB B Integral Inner Membrane, cytoplasmic side - Serine-type peptidase - Egan 2015; Nakagawa 1984; Schwartz 2001
AMPN_ECOLI
P04825
pepN Aminopeptidase N (EC 3.4.11.2) (Alpha-aminoacylpeptide hydrolase) cytoplasmic peripheral IM protein, Aminopeptidase PepN A,F1 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm - Metallopeptidase - Addlagatta 2008; Fournie-Zaluski 2009; Ito 2006
PTRA_ECOLI
P05458
ptrA Protease 3 (EC 3.4.24.55) (Pitrilysin) (Protease III) (Protease pi) periplasmic protein (SEC through IM), Protease 3 PtrA G Periplasmic - Metallopeptidase - Cheng 1979; Ding 1992; Han 2014; Lopez-Campistrous 2005
SPPA_ECOLI
P08395
sppA Protease 4 (EC 3.4.21.-) (Endopeptidase IV) (Protease IV) (Signal peptide peptidase) integral IM protein (SEC in IM), Protease 4 SppA B Integral Inner Membrane, cytoplasmic side - Serine-type peptidase - Ichihara 1986; Kim 2008; Saito 2011; Wang 2008
DACC_ECOLI
P08506
dacC D-alanyl-D-alanine carboxypeptidase DacC (DD-carboxypeptidase) (DD-peptidase) (EC 3.4.16.4) (Penicillin-binding protein 6) (PBP-6) periplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine carboxypeptidase DacC F2 Peripheral inner membrane protein facing the periplasm - Serine-type peptidase - Amanuma 1980; Amanuma 1984
OMPT_ECOLI
P09169
ompT Protease 7 (EC 3.4.23.49) (Omptin) (Outer membrane protein 3B) (Protease A) (Protease VII) OM b-barrel protein (SEC through IM, inserted in OM by BAM), Protease 7 OmpT H Outer Membrane b-barrel protein - Serine-type peptidase - Stumpe 1998
GLPG_ECOLI
P09391
glpG Rhomboid protease GlpG (EC 3.4.21.105) (Intramembrane serine protease) integral IM protein (SEC in IM), Rhomboid protease GlpG B Integral Inner Membrane, cytoplasmic side - Serine-type peptidase - Maegawa 2005; Wu 2006
CLPP_ECOLI
P0A6G7
clpP ATP-dependent Clp protease proteolytic subunit (EC 3.4.21.92) (Caseinolytic protease) (Endopeptidase Clp) (Heat shock protein F21.5) (Protease Ti) cytoplasmic protein, ATP-dependent Clp protease proteolytic subunit ClpP A Cytoplasmic ClpA, ClpX Serine-type peptidase Yes Flynn 2004; Kenniston 2003
HSLV_ECOLI
P0A7B8
hslV ATP-dependent protease subunit HslV (EC 3.4.25.2) (Heat shock protein HslV) cytoplasmic protein, ATP-dependent protease subunit HslV A Cytoplasmic HslU Threonine-type endopeptidase Yes Burton 2005; Rohrwild 1996; Seol 1997; Yoo 1996
PEPE_ECOLI
P0A7C6
pepE Peptidase E (EC 3.4.13.21) (Alpha-aspartyl dipeptidase) (Asp-specific dipeptidase) (Dipeptidase E) cytoplasmic protein, Peptidase E PepE A Cytoplasmic - Serine-type dipeptidase - Zhang 1998
LON_ECOLI
P0A9M0
lon Lon protease (EC 3.4.21.53) (ATP-dependent protease La) nucleoid protein, Lon protease Lon A,N Cytoplasmic, Nucleoid - Serine-type peptidase Yes Hansen 2012; Shah 2006; Thomas-Wohlever 2002; Vineyard 2006
FTSH_ECOLI
P0AAI3
ftsH ATP-dependent zinc metalloprotease FtsH (EC 3.4.24.-) (Cell division protease FtsH) integral IM protein (SEC in IM), ATP-dependent zinc metalloprotease FtsH B Integral Inner Membrane, cytoplasmic side - Metallopeptidase Yes Narberhaus 2009
MRDA_ECOLI
P0AD65
mrdA Peptidoglycan D,D-transpeptidase MrdA (EC 3.4.16.4) (Penicillin-binding protein 2) (PBP-2) integral IM protein (SEC in IM), PG D,D-transpeptidase MrdA B Integral Inner Membrane, cytoplasmic side - Serine-type peptidase - Ishino 1986
FTSI_ECOLI
P0AD68
ftsI Peptidoglycan D,D-transpeptidase FtsI (EC 3.4.16.4) (Essential cell division protein FtsI) (Murein transpeptidase) (Penicillin-binding protein 3) (PBP-3) (Peptidoglycan synthase FtsI) integral IM protein (SEC in IM), PG D,D-transpeptidase FtsI B Integral Inner Membrane, cytoplasmic side - Serine-type peptidase - Botta 1981; Ishino 1981; Nguyen-Disteche 1998; Pisabarro 1986; Spratt 1975
AMPH_ECOLI
P0AD70
ampH D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH (EC 3.4.-.-) (DD-alanine-endopeptidase) (DD-carboxypeptidase) (Penicillin-binding protein AmpH) cytoplasmic peripheral IM protein (SEC through IM), D-alanyl-D-alanine-carboxypeptidase/endopeptidase AmpH A,F1 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm - Endopeptidase/carboxypeptidase - Gonzalez-Leiza 2011
TESA_ECOLI
P0ADA1
tesA Thioesterase 1/protease 1/lysophospholipase L1 (TAP) (Acyl-CoA thioesterase 1) (TESA) (EC 3.1.2.2) (Acyl-CoA thioesterase I) (Arylesterase) (EC 3.1.1.2) (Lysophospholipase L1) (EC 3.1.1.5) (Oleoyl-[acyl-carrier-protein] hydrolase) (EC 3.1.2.14) (Phospholipid degradation C) (Pldc) (Protease 1) (EC 3.4.21.-) (Protease I) (Thioesterase I/protease I) (TEP-I) periplasmic protein (SEC through IM), Thioesterase 1/protease 1/lysophospholipase L1 TesA G Periplasmic - Peptidase - Ichihara 1993; Lee 1997
MAP1_ECOLI
P0AE18
map Methionine aminopeptidase (MAP) (MetAP) (EC 3.4.11.18) (Peptidase M) cytoplasmic peripheral IM protein, Methionine aminopeptidase Map A,F1 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm - Metallopeptidase - Ben-Bassat 1987; Xiao 2010
Records 1 to 20 of 82

The protease list is available in the downloads section:
Proteaseome .xlsx formrat or Proteaseome .csv format

For more information: Loos et al., 2019.