Essentialome of E.coli K-12 (MG1655)
| Protein Information | Subcellular Localization | Targeting/Export System | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Protein ID / Accession # (UniProt) |
Gene Name (UniProt) |
Protein Name (UniProt) |
Order Locus Name |
Protein Name (STEPdb) |
Reference structure |
Topology Class Full name (STEPdb) |
Symbol (STEPdb) |
Topology Class UniProt |
Extracellular Appendage | First Level Targeting Chaperoning |
First Level Secretion System |
Second Level Targeting Chaperoning |
Second Level Secretion System |
K-12 Core Proteome (yes/no) |
K-12 Basic Proteome (yes/no) |
| YKFM_ECOLI A5A605 |
ykfM | Uncharacterized protein YkfM | b4586 | integral IM protein (SEC in IM), YkfM | ab initio Zhang model E14116 (score: 0.604) | Integral Inner Membrane, cytoplasmic side | B | Membrane | - | SRP | SEC | - | - | no | yes |
| YMIB_ECOLI C1P5Z9 |
ymiB | Putative protein YmiB | b4672 JW1278.1 | integral IM protein (SEC in IM), Putative YmiB | TBM Zhang model E10799 (score: 0.617) | Integral Inner Membrane, cytoplasmic side | B | Membrane | - | SRP | SEC | - | - | no | yes |
| YNBG_ECOLI C1P600 |
ynbG | Uncharacterized protein YnbG | b4674 JW1395.1 | cytoplasmic protein, YnbG | no structure available | Cytoplasmic | A | - | - | - | - | - | - | no | yes |
| YOBI_ECOLI C1P604 |
yobI | Uncharacterized protein YobI | b4677 JW1850.1 | cytoplasmic peripheral IM protein, YobI | no structure available | Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm | A,F1 | - | - | - | - | - | - | no | yes |
| YQCG_ECOLI C1P612 |
yqcG | Uncharacterized protein YqcG | b4682 JW2748.1 | cytoplasmic protein, YqcG | no structure available | Cytoplasmic | A | - | - | - | - | - | - | no | yes |
| YQEL_ECOLI C1P613 |
yqeL | Uncharacterized protein YqeL | b4683 JW5455.1 | cytoplasmic protein, YqeL | no structure available | Cytoplasmic | A | - | - | - | - | - | - | no | yes |
| RIR1_ECOLI P00452 |
nrdA | Ribonucleoside-diphosphate reductase 1 subunit alpha (EC 1.17.4.1) (Protein B1) (Ribonucleoside-diphosphate reductase 1 R1 subunit) (Ribonucleotide reductase 1) | b2234 JW2228 | cytoplasmic peripheral IM protein, Ribonucleoside-diphosphate reductase 1 subunit alpha NrdA | 5r1r PDB ID, chain A, for protein P00452 | Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm | A,F1 | - | - | TF | - | - | - | yes | yes |
| RPOD_ECOLI P00579 |
rpoD | RNA polymerase sigma factor RpoD (Sigma-70) | b3067 JW3039 | cytoplasmic nucleoid peripheral IM protein, RNA polymerase sigma factor RpoD | 4lk1 PDB ID, chain F, for protein P00579 | Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm | A,N,F1 | Cytoplasm | - | TF | - | - | - | yes | yes |
| LEP_ECOLI P00803 |
lepB | Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I) | b2568 JW2552 | integral IM protein (SEC-YidC in IM), Signal peptidase I LepB | 1b12 PDB ID, chain A, for protein P00803 | Integral Inner Membrane, cytoplasmic side | B | Cell inner membrane | - | - | SEC-YidC | - | - | yes | yes |
| LSPA_ECOLI P00804 |
lspA | Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II) | b0027 JW0025 | integral IM protein (SEC in IM), Signal peptidase II LspA | modbase model P00804 (score: 0.6398211937) | Integral Inner Membrane, cytoplasmic side | B | Cell inner membrane | - | SRP | SEC | - | - | yes | yes |
| SYW_ECOLI P00954 |
trpS | Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) | b3384 JW3347 | cytoplasmic protein, Tryptophan--tRNA ligase TrpS | 5V0I PDB ID, chain A, for protein P00954 | Cytoplasmic | A | Cytoplasm | - | - | - | - | - | yes | yes |
| SYI_ECOLI P00956 |
ileS | Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) | b0026 JW0024 | cytoplasmic protein, Isoleucine--tRNA ligase IleS | TBM Zhang model E11897 (score: 0.975) | Cytoplasmic | A | Cytoplasm | - | - | - | - | - | yes | yes |
| SYA_ECOLI P00957 |
alaS | Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) | b2697 JW2667 | cytoplasmic nucleoid peripheral IM protein, Alanine--tRNA ligase AlaS | 3hy0 PDB ID, chain A, for protein P00957 | Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm | A,N,F1 | Cytoplasm | - | TF | - | - | - | no | yes |
| SYM_ECOLI P00959 |
metG | Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) | b2114 JW2101 | cytoplasmic peripheral IM protein, Methionine--tRNA ligase MetG | 1pfv PDB ID, chain A, for protein P00959 | Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm | A,F1 | Cytoplasm | - | TF | - | - | - | yes | yes |
| SYGA_ECOLI P00960 |
glyQ | Glycine--tRNA ligase alpha subunit (EC 6.1.1.14) (Glycyl-tRNA synthetase alpha subunit) (GlyRS) | b3560 JW3531 | cytoplasmic peripheral IM protein, Glycine--tRNA ligase alpha subunit GlyQ | TBM Zhang model E11709 (score: 0.946) | Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm | A,F1 | Cytoplasm | - | TF | - | - | - | no | yes |
| SYGB_ECOLI P00961 |
glyS | Glycine--tRNA ligase beta subunit (EC 6.1.1.14) (Glycyl-tRNA synthetase beta subunit) (GlyRS) | b3559 JW3530 | cytoplasmic peripheral IM protein, Glycine--tRNA ligase beta subunit GlyS | TBM Zhang model E11710 (score: 0.47) | Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm | A,F1 | Cytoplasm | - | - | - | - | - | yes | yes |
| SYQ_ECOLI P00962 |
glnS | Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) | b0680 JW0666 | cytoplasmic protein, Glutamine--tRNA ligase GlnS | 4jyz PDB ID, chain A, for protein P00962 | Cytoplasmic | A | Cytoplasm | - | - | - | - | - | yes | yes |
| RS6_ECOLI P02358 |
rpsF | 30S ribosomal protein S6 (Small ribosomal subunit protein bS6) [Cleaved into: 30S ribosomal protein S6, fully modified isoform; 30S ribosomal protein S6, non-modified isoform] | b4200 JW4158 | ribosomal protein, 30S S6 RpsF | 3j9z PDB ID, chain SF, for protein P02358 | Cytoplasmic, Ribosomal | A,r | - | ribosome | - | - | - | - | yes | yes |
| RS7_ECOLI P02359 |
rpsG | 30S ribosomal protein S7 (Small ribosomal subunit protein uS7) | b3341 JW3303 | ribosomal protein, 30S S7 RpsG | 3j9z PDB ID, chain SG, for protein P02359 | Cytoplasmic, Ribosomal | A,r | - | ribosome | - | - | - | - | yes | yes |
| RL15_ECOLI P02413 |
rplO | 50S ribosomal protein L15 (Large ribosomal subunit protein uL15) | b3301 JW3263 | ribosomal protein, 50S L15 RplO | 4ybb PDB ID, chain CM, for protein P02413 | Cytoplasmic, Ribosomal | A,r | - | ribosome | - | - | - | - | yes | yes |
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