Essentialome of E.coli K-12 (MG1655)

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Nucleoid Cytoplasmic Peripheral inner membrane protein facing the cytoplasm Integral inner membrane Ribosomal Inner membrane lipoprotein Peripheral inner membrane protein facing the periplasm Periplasmic Peripheral outer membrane protein facing the periplasm Outer membrane β-barrel protein Peripheral outer membrane protein facing the extra-cellular space Extra-cellular Outer membrane lipoprotein

Protein Information Subcellular Localization Targeting/Export System
Protein ID /
Accession #
(UniProt)
Gene Name
(UniProt)
Protein Name
(UniProt)
Order
Locus Name
Protein Name
(STEPdb)
Reference structure
Topology Class
Full name
(STEPdb)
Symbol
(STEPdb)
Topology Class
UniProt
Extracellular Appendage First Level
Targeting
Chaperoning
First Level
Secretion
System
Second Level
Targeting
Chaperoning
Second Level
Secretion
System
K-12 Core
Proteome
(yes/no)
K-12 Basic
Proteome
(yes/no)
YKFM_ECOLI
A5A605
ykfM Uncharacterized protein YkfM b4586 integral IM protein (SEC in IM), YkfM ab initio Zhang model E14116 (score: 0.604) Integral Inner Membrane, cytoplasmic side B Membrane - SRP SEC - - no yes
YMIB_ECOLI
C1P5Z9
ymiB Putative protein YmiB b4672 JW1278.1 integral IM protein (SEC in IM), Putative YmiB TBM Zhang model E10799 (score: 0.617) Integral Inner Membrane, cytoplasmic side B Membrane - SRP SEC - - no yes
YNBG_ECOLI
C1P600
ynbG Uncharacterized protein YnbG b4674 JW1395.1 cytoplasmic protein, YnbG no structure available Cytoplasmic A - - - - - - no yes
YOBI_ECOLI
C1P604
yobI Uncharacterized protein YobI b4677 JW1850.1 cytoplasmic peripheral IM protein, YobI no structure available Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm A,F1 - - - - - - no yes
YQCG_ECOLI
C1P612
yqcG Uncharacterized protein YqcG b4682 JW2748.1 cytoplasmic protein, YqcG no structure available Cytoplasmic A - - - - - - no yes
YQEL_ECOLI
C1P613
yqeL Uncharacterized protein YqeL b4683 JW5455.1 cytoplasmic protein, YqeL no structure available Cytoplasmic A - - - - - - no yes
RIR1_ECOLI
P00452
nrdA Ribonucleoside-diphosphate reductase 1 subunit alpha (EC 1.17.4.1) (Protein B1) (Ribonucleoside-diphosphate reductase 1 R1 subunit) (Ribonucleotide reductase 1) b2234 JW2228 cytoplasmic peripheral IM protein, Ribonucleoside-diphosphate reductase 1 subunit alpha NrdA 5r1r PDB ID, chain A, for protein P00452 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm A,F1 - - TF - - - yes yes
RPOD_ECOLI
P00579
rpoD RNA polymerase sigma factor RpoD (Sigma-70) b3067 JW3039 cytoplasmic nucleoid peripheral IM protein, RNA polymerase sigma factor RpoD 4lk1 PDB ID, chain F, for protein P00579 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm - TF - - - yes yes
LEP_ECOLI
P00803
lepB Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I) b2568 JW2552 integral IM protein (SEC-YidC in IM), Signal peptidase I LepB 1b12 PDB ID, chain A, for protein P00803 Integral Inner Membrane, cytoplasmic side B Cell inner membrane - - SEC-YidC - - yes yes
LSPA_ECOLI
P00804
lspA Lipoprotein signal peptidase (EC 3.4.23.36) (Prolipoprotein signal peptidase) (Signal peptidase II) (SPase II) b0027 JW0025 integral IM protein (SEC in IM), Signal peptidase II LspA modbase model P00804 (score: 0.6398211937) Integral Inner Membrane, cytoplasmic side B Cell inner membrane - SRP SEC - - yes yes
SYW_ECOLI
P00954
trpS Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) b3384 JW3347 cytoplasmic protein, Tryptophan--tRNA ligase TrpS 5V0I PDB ID, chain A, for protein P00954 Cytoplasmic A Cytoplasm - - - - - yes yes
SYI_ECOLI
P00956
ileS Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) b0026 JW0024 cytoplasmic protein, Isoleucine--tRNA ligase IleS TBM Zhang model E11897 (score: 0.975) Cytoplasmic A Cytoplasm - - - - - yes yes
SYA_ECOLI
P00957
alaS Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) b2697 JW2667 cytoplasmic nucleoid peripheral IM protein, Alanine--tRNA ligase AlaS 3hy0 PDB ID, chain A, for protein P00957 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm - TF - - - no yes
SYM_ECOLI
P00959
metG Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) b2114 JW2101 cytoplasmic peripheral IM protein, Methionine--tRNA ligase MetG 1pfv PDB ID, chain A, for protein P00959 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm A,F1 Cytoplasm - TF - - - yes yes
SYGA_ECOLI
P00960
glyQ Glycine--tRNA ligase alpha subunit (EC 6.1.1.14) (Glycyl-tRNA synthetase alpha subunit) (GlyRS) b3560 JW3531 cytoplasmic peripheral IM protein, Glycine--tRNA ligase alpha subunit GlyQ TBM Zhang model E11709 (score: 0.946) Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm A,F1 Cytoplasm - TF - - - no yes
SYGB_ECOLI
P00961
glyS Glycine--tRNA ligase beta subunit (EC 6.1.1.14) (Glycyl-tRNA synthetase beta subunit) (GlyRS) b3559 JW3530 cytoplasmic peripheral IM protein, Glycine--tRNA ligase beta subunit GlyS TBM Zhang model E11710 (score: 0.47) Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm A,F1 Cytoplasm - - - - - yes yes
SYQ_ECOLI
P00962
glnS Glutamine--tRNA ligase (EC 6.1.1.18) (Glutaminyl-tRNA synthetase) (GlnRS) b0680 JW0666 cytoplasmic protein, Glutamine--tRNA ligase GlnS 4jyz PDB ID, chain A, for protein P00962 Cytoplasmic A Cytoplasm - - - - - yes yes
RS6_ECOLI
P02358
rpsF 30S ribosomal protein S6 (Small ribosomal subunit protein bS6) [Cleaved into: 30S ribosomal protein S6, fully modified isoform; 30S ribosomal protein S6, non-modified isoform] b4200 JW4158 ribosomal protein, 30S S6 RpsF 3j9z PDB ID, chain SF, for protein P02358 Cytoplasmic, Ribosomal A,r - ribosome - - - - yes yes
RS7_ECOLI
P02359
rpsG 30S ribosomal protein S7 (Small ribosomal subunit protein uS7) b3341 JW3303 ribosomal protein, 30S S7 RpsG 3j9z PDB ID, chain SG, for protein P02359 Cytoplasmic, Ribosomal A,r - ribosome - - - - yes yes
RL15_ECOLI
P02413
rplO 50S ribosomal protein L15 (Large ribosomal subunit protein uL15) b3301 JW3263 ribosomal protein, 50S L15 RplO 4ybb PDB ID, chain CM, for protein P02413 Cytoplasmic, Ribosomal A,r - ribosome - - - - yes yes
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