Proteins with multiple sub-cellular topologies in E.coli K-12 (MG1655)

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Nucleoid Cytoplasmic Peripheral inner membrane protein facing the cytoplasm Integral inner membrane Ribosomal Inner membrane lipoprotein Peripheral inner membrane protein facing the periplasm Periplasmic Peripheral outer membrane protein facing the periplasm Outer membrane β-barrel protein Peripheral outer membrane protein facing the extra-cellular space Extra-cellular Outer membrane lipoprotein

Protein Information Subcellular Localization Targeting/Export System
Protein ID /
Accession #
(UniProt)		 Gene Name
(UniProt)		 Protein Name
(UniProt)		 Order
Locus Name		 Protein Name
(STEPdb)		 Reference structure
Topology Class
Full name
(STEPdb)		 Symbol
(STEPdb)		 Topology Class
UniProt		 Extracellular Appendage First Level
Targeting
Chaperoning		 First Level
Secretion
System		 Second Level
Targeting
Chaperoning		 Second Level
Secretion
System		 K-12 Core
Proteome
(yes/no)		 K-12 Basic
Proteome
(yes/no)
RPOD_ECOLI
P00579		 rpoD RNA polymerase sigma factor RpoD (Sigma-70) b3067 JW3039 cytoplasmic nucleoid peripheral IM protein, RNA polymerase sigma factor RpoD 4lk1 PDB ID, chain F, for protein P00579 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm - TF - - - yes yes
DPO1_ECOLI
P00582		 polA DNA polymerase I (POL I) (EC 2.7.7.7) b3863 JW3835 cytoplasmic nucleoid peripheral IM protein, DNA polymerase I PolA 1d8y PDB ID, chain A, for protein P00582 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 - - - - - - no yes
SYA_ECOLI
P00957		 alaS Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) b2697 JW2667 cytoplasmic nucleoid peripheral IM protein, Alanine--tRNA ligase AlaS 3hy0 PDB ID, chain A, for protein P00957 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm - TF - - - no yes
DNAA_ECOLI
P03004		 dnaA Chromosomal replication initiator protein DnaA b3702 JW3679 cytoplasmic nucleoid peripheral IM protein, Chromosomal replication initiator DnaA TBM Zhang model E11330 (score: 0.786) Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm - - - - - no yes
ERA_ECOLI
P06616		 era GTPase Era (ERA) (GTP-binding protein Era) b2566 JW2550 ribosomal cytoplasmic peripheral IM protein, GTPase Era 1ega PDB ID, chain B, for protein P06616 Cytoplasmic, Peripheral plasma membrane protein facing the cytoplasm, Ribosomal A,F1,r Cytoplasm - - - - - yes yes
BIRA_ECOLI
P06709		 birA Bifunctional ligase/repressor BirA (Biotin operon repressor) (Biotin--[acetyl-CoA-carboxylase] ligase) (EC 6.3.4.15) (Biotin--protein ligase) (Biotin-[acetyl-CoA carboxylase] synthetase) b3973 JW3941 nucleoid & integral IM protein (SEC in IM), Bifunctional ligase/repressor BirA 2ewn PDB ID, chain A, for protein P06709 Integral Inner Membrane, Nucleoid B,N - - SRP SEC - - yes yes
MALT_ECOLI
P06993		 malT HTH-type transcriptional regulator MalT (ATP-dependent transcriptional activator MalT) b3418 JW3381 cytoplasmic nucleoid peripheral IM protein, HTH-type transcriptional regulator MalT 1hz4 PDB ID, chain A, for protein P06993 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 - - TF - - - yes yes
PUTA_ECOLI
P09546		 putA Bifunctional protein PutA [Includes: Proline dehydrogenase (EC 1.5.5.2) (Proline oxidase); Delta-1-pyrroline-5-carboxylate dehydrogenase (P5C dehydrogenase) (EC 1.2.1.88) (L-glutamate gamma-semialdehyde dehydrogenase)] b1014 JW0999 cytoplasmic nucleoid peripheral IM protein, Bifunctional PutA 4jnz PDB ID, chain A, for protein P09546 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 - - - - - - yes yes
DER_ECOLI
P0A6P5		 der GTPase Der (Double era-like domain protein) (GTP-binding protein EngA) b2511 JW5403 ribosomal cytoplasmic peripheral IM protein, GTPase Der 3j8g PDB ID, chain X, for protein P0A6P5 Cytoplasmic, Peripheral plasma membrane protein facing the cytoplasm, Ribosomal A,F1,r - - - - - - yes yes
ENO_ECOLI
P0A6P9		 eno Enolase (EC 4.2.1.11) (2-phospho-D-glycerate hydro-lyase) (2-phosphoglycerate dehydratase) b2779 JW2750 cytoplasmic peripheral IM protein facing the cytoplasm & peripheral OM protein facing the extra-cellular space (SEC through IM), Enolase Eno 5ohg PDB ID, chain B, for protein P0A6P9 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm, Peripheral outer membrane protein facing the extra-cellular space A,F1,F4 Cytoplasm, cytoskeleton Secreted Cell surface - - SEC - - yes yes
FIS_ECOLI
P0A6R3		 fis DNA-binding protein Fis (Factor-for-inversion stimulation protein) (Hin recombinational enhancer-binding protein) b3261 JW3229 cytoplasmic nucleoid peripheral IM protein, DNA-binding Fis 5ds9 PDB ID, chain B, for protein P0A6R3 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm, nucleoid - - - - - yes yes
HFQ_ECOLI
P0A6X3		 hfq RNA-binding protein Hfq (HF-1) (Host factor-I protein) (HF-I) b4172 JW4130 cytoplasmic nucleoid peripheral IM protein, RNA-binding Hfq 4v2s PDB ID, chain A, for protein P0A6X3 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 - - - - - - yes yes
IHFA_ECOLI
P0A6X7		 ihfA Integration host factor subunit alpha (IHF-alpha) b1712 JW1702 cytoplasmic nucleoid peripheral IM protein, Integration host factor subunit alpha IhfA 1owf PDB ID, chain A, for protein P0A6X7 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm, nucleoid - - - - - no yes
IHFB_ECOLI
P0A6Y1		 ihfB Integration host factor subunit beta (IHF-beta) b0912 JW0895 cytoplasmic nucleoid peripheral IM protein, Integration host factor subunit beta IhfB 1owf PDB ID, chain B, for protein P0A6Y1 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm - - - - - no yes
IF2_ECOLI
P0A705		 infB Translation initiation factor IF-2 b3168 JW3137 ribosomal cytoplasmic peripheral IM protein, Translation initiation factor IF-2 InfB 3jcj PDB ID, chain f, for protein P0A705 Cytoplasmic, Peripheral plasma membrane protein facing the cytoplasm, Ribosomal A,F1,r Cytoplasm - TF - - - yes yes
IF3_ECOLI
P0A707		 infC Translation initiation factor IF-3 [Cleaved into: Translation initiation factor IF-3, N-terminally processed; Translation initiation factor IF-3S] b1718 JW5829 ribosomal cytoplasmic peripheral IM protein, Translation initiation factor IF-3 InfC 5me0 PDB ID, chain Z, for protein P0A707 Cytoplasmic, Peripheral plasma membrane protein facing the cytoplasm, Ribosomal A,F1,r Cytoplasm - TF - - - no yes
RPPH_ECOLI
P0A776		 rppH RNA pyrophosphohydrolase (EC 3.6.1.-) ((Di)nucleoside polyphosphate hydrolase) (Ap5A pyrophosphatase) b2830 JW2798 cytoplasmic nucleoid peripheral IM protein, RNA pyrophosphohydrolase RppH 4s2x PDB ID, chain A, for protein P0A776 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 - - - - - - yes yes
RECF_ECOLI
P0A7H0		 recF DNA replication and repair protein RecF b3700 JW3677 cytoplasmic nucleoid peripheral IM protein, DNA replication and repair RecF TBM Zhang model E12673 (score: 0.679) Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm - - - - - yes yes
RIMM_ECOLI
P0A7X6		 rimM Ribosome maturation factor RimM (21K) b2608 JW5413 ribosomal cytoplasmic peripheral IM protein, Ribosome maturation factor RimM TBM Zhang model E12738 (score: 0.626) Cytoplasmic, Peripheral plasma membrane protein facing the cytoplasm, Ribosomal A,F1,r Cytoplasm - - - - - yes yes
RNC_ECOLI
P0A7Y0		 rnc Ribonuclease 3 (EC 3.1.26.3) (Ribonuclease III) (RNase III) b2567 JW2551 cytoplasmic nucleoid peripheral IM protein, Ribonuclease 3 Rnc TBM Zhang model E12760 (score: 0.887) Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm - TF - - - yes yes
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