E. coli K-12 / MG1655/ ATCC 47076 proteome

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Nucleoid Cytoplasmic Peripheral inner membrane protein facing the cytoplasm Integral inner membrane Ribosomal Inner membrane lipoprotein Peripheral inner membrane protein facing the periplasm Periplasmic Peripheral outer membrane protein facing the periplasm Outer membrane β-barrel protein Peripheral outer membrane protein facing the extra-cellular space Extra-cellular Outer membrane lipoprotein

Protein Information Subcellular Localization Targeting/Export System
Protein ID /
Accession #
(UniProt)
Gene Name
(UniProt)
Protein Name
(UniProt)
Order
Locus Name
Protein Name
(STEPdb)
Reference structure
Topology Class
Full name
(STEPdb)
Symbol
(STEPdb)
Topology Class
UniProt
Extracellular Appendage First Level
Targeting
Chaperoning
First Level
Secretion
System
Second Level
Targeting
Chaperoning
Second Level
Secretion
System
K-12 Core
Proteome
(yes/no)
K-12 Basic
Proteome
(yes/no)
PHSM_ECOLI
P00490
malP Maltodextrin phosphorylase (EC 2.4.1.1) b3417 JW5689 integral IM protein (SEC in IM), Maltodextrin phosphorylase MalP 1l5w PDB ID, chain A, for protein P00490 Integral Inner Membrane, cytoplasmic side B - - - SEC - - yes yes
AK2H_ECOLI
P00562
metL Bifunctional aspartokinase/homoserine dehydrogenase 2 (Aspartokinase II/homoserine dehydrogenase II) (AKII-HDII) [Includes: Aspartokinase (EC 2.7.2.4); Homoserine dehydrogenase (EC 1.1.1.3)] b3940 JW3911 cytoplasmic peripheral IM protein, Bifunctional aspartokinase/homoserine dehydrogenase 2 MetL TBM Zhang model E12163 (score: 0.725) Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm A,F1 - - - - - - yes yes
DPO1_ECOLI
P00582
polA DNA polymerase I (POL I) (EC 2.7.7.7) b3863 JW3835 cytoplasmic nucleoid peripheral IM protein, DNA polymerase I PolA 1d8y PDB ID, chain A, for protein P00582 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 - - - - - - no yes
LEP_ECOLI
P00803
lepB Signal peptidase I (SPase I) (EC 3.4.21.89) (Leader peptidase I) b2568 JW2552 integral IM protein (SEC-YidC in IM), Signal peptidase I LepB 1b12 PDB ID, chain A, for protein P00803 Integral Inner Membrane, cytoplasmic side B Cell inner membrane - - SEC-YidC - - yes yes
AROH_ECOLI
P00887
aroH Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive (EC 2.5.1.54) (3-deoxy-D-arabino-heptulosonate 7-phosphate synthase) (DAHP synthase) (Phospho-2-keto-3-deoxyheptonate aldolase) b1704 JW1694 cytoplasmic protein, Phospho-2-dehydro-3-deoxyheptonate aldolase, Trp-sensitive AroH TBM Zhang model E11025 (score: 0.95) Cytoplasmic A - - - - - - yes yes
SYW_ECOLI
P00954
trpS Tryptophan--tRNA ligase (EC 6.1.1.2) (Tryptophanyl-tRNA synthetase) (TrpRS) b3384 JW3347 cytoplasmic protein, Tryptophan--tRNA ligase TrpS 5V0I PDB ID, chain A, for protein P00954 Cytoplasmic A Cytoplasm - - - - - yes yes
SYI_ECOLI
P00956
ileS Isoleucine--tRNA ligase (EC 6.1.1.5) (Isoleucyl-tRNA synthetase) (IleRS) b0026 JW0024 cytoplasmic protein, Isoleucine--tRNA ligase IleS TBM Zhang model E11897 (score: 0.975) Cytoplasmic A Cytoplasm - - - - - yes yes
SYA_ECOLI
P00957
alaS Alanine--tRNA ligase (EC 6.1.1.7) (Alanyl-tRNA synthetase) (AlaRS) b2697 JW2667 cytoplasmic nucleoid peripheral IM protein, Alanine--tRNA ligase AlaS 3hy0 PDB ID, chain A, for protein P00957 Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm - TF - - - no yes
SYM_ECOLI
P00959
metG Methionine--tRNA ligase (EC 6.1.1.10) (Methionyl-tRNA synthetase) (MetRS) b2114 JW2101 cytoplasmic peripheral IM protein, Methionine--tRNA ligase MetG 1pfv PDB ID, chain A, for protein P00959 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm A,F1 Cytoplasm - TF - - - yes yes
PBPB_ECOLI
P02919
mrcB Penicillin-binding protein 1B (PBP-1b) (PBP1b) (Murein polymerase) [Includes: Penicillin-insensitive transglycosylase (EC 2.4.1.129) (Peptidoglycan TGase) (Peptidoglycan glycosyltransferase); Penicillin-sensitive transpeptidase (EC 3.4.16.4) (DD-transpeptidase)] b0149 JW0145 integral IM protein (SEC in IM), Penicillin-binding 1B MrcB 5hlb PDB ID, chain A, for protein P02919 Integral Inner Membrane, cytoplasmic side B Cell inner membrane, Single-pass type II membrane protein - SRP SEC - - yes yes
DNAA_ECOLI
P03004
dnaA Chromosomal replication initiator protein DnaA b3702 JW3679 cytoplasmic nucleoid peripheral IM protein, Chromosomal replication initiator DnaA TBM Zhang model E11330 (score: 0.786) Cytoplasmic, Nucleoid, Peripheral inner membrane protein facing the cytoplasm A,N,F1 Cytoplasm - - - - - no yes
DAPB_ECOLI
P04036
dapB 4-hydroxy-tetrahydrodipicolinate reductase (HTPA reductase) (EC 1.17.1.8) b0031 JW0029 cytoplasmic protein, 4-hydroxy-tetrahydrodipicolinate reductase DapB 1dih PDB ID, chain A, for protein P04036 Cytoplasmic A Cytoplasm - - - - - yes yes
AMPN_ECOLI
P04825
pepN Aminopeptidase N (EC 3.4.11.2) (Alpha-aminoacylpeptide hydrolase) b0932 JW0915 cytoplasmic peripheral IM protein, Aminopeptidase PepN 4xo4 PDB ID, chain A, for protein P04825 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm A,F1 Cell inner membrane, Cytoplasmic side, Peripheral membrane protein - - - - - yes yes
EX7L_ECOLI
P04994
xseA Exodeoxyribonuclease 7 large subunit (EC 3.1.11.6) (Exodeoxyribonuclease VII large subunit) (Exonuclease VII large subunit) b2509 JW2493 nucleoid protein, Exodeoxyribonuclease 7 large subunit XseA TBM Zhang model E13191 (score: 0.694) Cytoplasmic, Nucleoid A,N Cytoplasm - - - - - no yes
PNP_ECOLI
P05055
pnp Polyribonucleotide nucleotidyltransferase (EC 2.7.7.8) (Polynucleotide phosphorylase) (PNPase) b3164 JW5851 cytoplasmic peripheral IM protein, Polyribonucleotide nucleotidyltransferase Pnp 3h1c PDB ID, chain A, for protein P05055 Cytoplasmic, Peripheral inner membrane protein facing the cytoplasm A,F1 Cytoplasm - TF - - - yes yes
AROD_ECOLI
P05194
aroD 3-dehydroquinate dehydratase (3-dehydroquinase) (EC 4.2.1.10) (Type I DHQase) (Type I dehydroquinase) (DHQ1) b1693 JW1683 cytoplasmic protein, 3-dehydroquinate dehydratase AroD TBM Zhang model E11021 (score: 0.886) Cytoplasmic A - - - - - - yes yes
PTRA_ECOLI
P05458
ptrA Protease 3 (EC 3.4.24.55) (Pitrilysin) (Protease III) (Protease pi) b2821 JW2789 periplasmic protein (SEC through IM), Protease 3 PtrA 1q2l PDB ID, chain A, for protein P05458 Periplasmic G Periplasm - - SEC SURA - yes yes
APAH_ECOLI
P05637
apaH Bis(5'-nucleosyl)-tetraphosphatase [symmetrical] (EC 3.6.1.41) (Ap4A hydrolase) (Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase) (Diadenosine tetraphosphatase) b0049 JW0048 cytoplasmic protein, Bis(5'-nucleosyl)-tetraphosphatase ApaH TBM Zhang model E10978 (score: 0.708) Cytoplasmic A - - - - - - yes yes
CCA_ECOLI
P06961
cca Multifunctional CCA protein [Includes: CCA-adding enzyme (EC 2.7.7.72) (CCA tRNA nucleotidyltransferase) (tRNA CCA-pyrophosphorylase) (tRNA adenylyl-/cytidylyl-transferase) (tRNA nucleotidyltransferase) (tRNA-NT); 2'-nucleotidase (EC 3.1.3.-); 2',3'-cyclic phosphodiesterase (EC 3.1.4.-); Phosphatase (EC 3.1.3.-)] b3056 JW3028 cytoplasmic protein, Multifunctional CCA TBM Zhang model E11131 (score: 0.816) Cytoplasmic A - - - - - - yes yes
PFKB_ECOLI
P06999
pfkB ATP-dependent 6-phosphofructokinase isozyme 2 (ATP-PFK 2) (Phosphofructokinase 2) (EC 2.7.1.11) (6-phosphofructokinase isozyme II) (Phosphohexokinase 2) b1723 JW5280 cytoplasmic protein, ATP-dependent 6-phosphofructokinase isozyme 2 PfkB 3umo PDB ID, chain A, for protein P06999 Cytoplasmic A - - - - - - yes yes
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